Strain Name:

STOCK Ntf3tm1Jae/J

Stock Number:

002276

Order this mouse

Availability:

Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
 
Donating InvestigatorDr. Rudolf Jaenisch,   Whitehead Institute (MIT)

Appearance
multiple coat colors
Related Genotype: segregating for a, Aw, Tyrp1b, and Tyrc

Description
Mice homozygous for the Ntf3tm1Jae targeted mutation are smaller than their normal littermates and most die shortly after birth. Survivors die prior to weaning. They display limb ataxia, an inability to position the limbs properly when attempting to move, and there is a tendency for all four limbs to intermittently stiffen in an extensor posture. Autopsy showed all peripheral ganglia markedly smaller in the mutant. Spinal proprioceptive afferents and their peripheral sense organs are completely absent. Heterozygous mice appear normal; however, the number of muscle spindles in heterozygotes is half that of normal wildtype siblings. There is approximately a 50% reduction in the sympathetic superior cervical ganglion (SCG) neurons caused by excessive apoptosis of sympathetic neuroblasts during neurogenesis.

Control Information

  Control
   See control note: Wildtype mice from the colony may be used as controls. This strain is a mixture of 129S4/SvJae, BALB/c and C57BL/6J inbred strains.
   Wild-type from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Ntf3tm1Jae allele
002275   B6.129S4-Ntf3tm1Jae/J
View Strains carrying   Ntf3tm1Jae     (1 strain)

Strains carrying other alleles of Ntf3
003541   B6.129S4-Ntf3tm2Jae/J
View Strains carrying other alleles of Ntf3     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Ntf3tm1Jae/Ntf3+

        involves: 129S4/SvJae * BALB/c
  • nervous system phenotype
  • abnormal dorsal root ganglion morphology
    • mice exhibit a loss of myelinated fibers in the dorsal root ganglion   (MGI Ref ID J:53825)
  • abnormal stellate ganglion morphology
    • fewer stellate ganglion neurons at P0 and P60 than in wild-type   (MGI Ref ID J:62748)
  • decreased sensory neuron number
    • mice exhibit a 17% loss in sensory neurons in the dorsal root ganglion   (MGI Ref ID J:53825)
  • cardiovascular system phenotype
  • abnormal cardiovascular system physiology
    • adults exhibit lower sympathetic tonus than wild-type   (MGI Ref ID J:62748)
    • decreased heart rate
      • adults exhibit lower resting heart rates than wild-type   (MGI Ref ID J:62748)
  • homeostasis/metabolism phenotype
  • abnormal noradrenaline level
    • 37% decrease in adult heart ventricular norepinephrine concentrations, however no differences seen at birth   (MGI Ref ID J:62748)
  • muscle phenotype
  • abnormal muscle morphology
    • 50% reduction of muscle spindles   (MGI Ref ID J:23882)
    • muscles exhibit fewer myelinated fibers than in wild-type mice (52+/-4 compared to 76+/-2 in wild-type mice)   (MGI Ref ID J:53825)

Ntf3tm1Jae/Ntf3tm1Jae

        involves: 129S4/SvJae * BALB/c
  • mortality/aging
  • complete postnatal lethality
    • by 3 weeks of age   (MGI Ref ID J:23882)
  • behavior/neurological phenotype
  • abnormal sensory capabilities/reflexes/nociception
    • exhibit a tendency of all four limbs to intermittently stiffen in an extensor posture   (MGI Ref ID J:23882)
  • ataxia
    • limb ataxia   (MGI Ref ID J:23882)
  • impaired limb coordination
    • display an inability to position the extremities properly when attempting to move   (MGI Ref ID J:23882)
  • growth/size/body phenotype
  • decreased body size
    • retardation   (MGI Ref ID J:23882)
    • decreased body weight
      • weigh 20% less than controls at birth   (MGI Ref ID J:62748)
  • muscle phenotype
  • abnormal muscle morphology   (MGI Ref ID J:23882)
    • absent golgi tendon organ   (MGI Ref ID J:23882)
    • absent muscle spindles
      • absent muscle spindles   (MGI Ref ID J:23882)
  • nervous system phenotype
  • abnormal dorsal root ganglion morphology
    • loss of carbonic anhydrase (CA) positive neurons, which are mostly L4 dorsal root ganglion neurons   (MGI Ref ID J:23882)
    • abnormal proprioceptive neuron morphology
      • central branch of the proprioceptive Ia fibers innvervating spinal cord layer IX is absent   (MGI Ref ID J:23882)
    • small dorsal root ganglion   (MGI Ref ID J:23882)
  • abnormal innervation pattern to muscle
    • show no evidence of afferent nerve fiber-muscle contacts   (MGI Ref ID J:23882)
  • abnormal stellate ganglion morphology
    • fewer stellate ganglion neurons at P0 and P60 than in heterozygotes or wild-type   (MGI Ref ID J:62748)
  • absent golgi tendon organ   (MGI Ref ID J:23882)
  • absent muscle spindles
    • absent muscle spindles   (MGI Ref ID J:23882)
  • small mesencephalic trigeminal nucleus   (MGI Ref ID J:23882)
  • small nodose ganglion   (MGI Ref ID J:23882)
  • small superior cervical ganglion   (MGI Ref ID J:23882)
  • small trigeminal ganglion   (MGI Ref ID J:23882)

Ntf3tm1Jae/Ntf3tm1Jae

        involves: 129S4/SvJae * C57BL/6J
  • nervous system phenotype
  • abnormal innervation pattern to muscle
    • on P1 the fungiform papillae of the tongue are partially denervated   (MGI Ref ID J:90280)
  • abnormal sensory neuron innervation pattern
    • innervation of the somatosensory prominences is virtually absent   (MGI Ref ID J:90280)

Ntf3tm1Jae/Ntf3tm1Jae

        involves: 129S4/SvJae
  • mortality/aging
  • complete postnatal lethality
    • mutants die soon after birth from cardiac defects   (MGI Ref ID J:43444)
  • nervous system phenotype
  • abnormal dorsal root ganglion morphology
    • a 63% decrease compared to wild-type in the overall number of dorsal root ganglia neurons at L4 is seen in newborn mice   (MGI Ref ID J:43444)
    • absent proprioceptive neurons
      • essentially no proprioceptive neurons are present   (MGI Ref ID J:43444)
  • absent muscle spindles
    • no spindle bundles are seen   (MGI Ref ID J:43444)
  • muscle phenotype
  • absent muscle spindles
    • no spindle bundles are seen   (MGI Ref ID J:43444)

Ntf3tm1Jae/Ntf3tm1Jae

        involves: 129S4/SvJae * C57BL/6
  • nervous system phenotype
  • abnormal dorsal root ganglion morphology
    • 70% of dorsal root ganglia neurons are lost relative to in wild-type mice   (MGI Ref ID J:83461)
    • absent proprioceptive neurons
      • proprioceptive neurons are lost   (MGI Ref ID J:83461)
  • absent muscle spindles
    • no muscle spindles are found in the soleus muscle during development and at later stages   (MGI Ref ID J:83461)
  • muscle phenotype
  • absent muscle spindles
    • no muscle spindles are found in the soleus muscle during development and at later stages   (MGI Ref ID J:83461)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Ntf3tm1Jae related

Apoptosis Research
Extracellular Modulators

Cancer Research
Genes Regulating Growth and Proliferation
Growth Factors/Receptors/Cytokines

Developmental Biology Research
Mesodermal Defects
      Myogenesis Defects

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines
Inflammation

Neurobiology Research
Ataxia (Movement) Defects
Neurotrophic Factor Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ntf3tm1Jae
Allele Name targeted mutation 1, Rudolf Jaenisch
Allele Type Targeted (Null/Knockout)
Common Name(s) NT-3-; NT3-;
Mutation Made ByDr. Rudolf Jaenisch,   Whitehead Institute (MIT)
Strain of Origin129S4/SvJae
ES Cell Line NameJ1
ES Cell Line Strain129S4/SvJae
Gene Symbol and Name Ntf3, neurotrophin 3
Chromosome 6
Gene Common Name(s) AI316846; AI835689; EST AI316846; HDNF; NGF-2; NGF2; NT-3; NT3; Ntf-3; expressed sequence AI835689;
Molecular Note The entire coding region for the Ntf3 gene was replaced by a neomycin cassette. [MGI Ref ID J:23882]

Genotyping

Genotyping Information

Genotyping Protocols

NEOTD (Generic Neo), Standard PCR
Ntf3tm1Jae, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Ntf3tm1Jae related

Andres R; Herraez-Baranda LA; Thompson J; Wyatt S; Davies AM. 2008. Regulation of sympathetic neuron differentiation by endogenous nerve growth factor and neurotrophin-3. Neurosci Lett 431(3):241-6. [PubMed: 18162309]  [MGI Ref ID J:141631]

Asztely F; Kokaia M; Olofsdotter K; Ortegren U; Lindvall O. 2000. Afferent-specific modulation of short-term synaptic plasticity by neurotrophins in dentate gyrus. Eur J Neurosci 12(2):662-9. [PubMed: 10712646]  [MGI Ref ID J:108125]

Botchkarev VA; Botchkarev NV; Albers KM; van der Veen C; Lewin GR; Paus R. 1998. Neurotrophin-3 involvement in the regulation of hair follicle morphogenesis. J Invest Dermatol 111(2):279-85. [PubMed: 9699730]  [MGI Ref ID J:65041]

Botchkarev VA; Welker P; Albers KM; Botchkareva NV; Metz M; Lewin GR; Bulfone-Paus S; Peters EM; Lindner G; Paus R. 1998. A new role for neurotrophin-3: involvement in the regulation of hair follicle regression (catagen). Am J Pathol 153(3):785-99. [PubMed: 9736028]  [MGI Ref ID J:49792]

Canals JM; Pineda JR; Torres-Peraza JF; Bosch M; Martin-Ibanez R; Munoz MT; Mengod G; Ernfors P; Alberch J. 2004. Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease. J Neurosci 24(35):7727-39. [PubMed: 15342740]  [MGI Ref ID J:92634]

ElShamy WM; Ernfors P. 1996. A local action of neurotrophin-3 prevents the death of proliferating sensory neuron precursor cells. Neuron 16(5):963-72. [PubMed: 8630254]  [MGI Ref ID J:33221]

ElShamy WM; Ernfors P. 1997. Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 complement and cooperate with each other sequentially during visceral neuron development. J Neurosci 17(22):8667-75. [PubMed: 9348335]  [MGI Ref ID J:44086]

ElShamy WM; Fridvall LK; Ernfors P. 1998. Growth arrest failure, G1 restriction point override, and S phase death of sensory precursor cells in the absence of neurotrophin-3. Neuron 21(5):1003-15. [PubMed: 9856457]  [MGI Ref ID J:51430]

ElShamy WM; Linnarsson S; Lee KF; Jaenisch R; Ernfors P. 1996. Prenatal and postnatal requirements of NT-3 for sympathetic neuroblast survival and innervation of specific targets. Development 122(2):491-500. [PubMed: 8625800]  [MGI Ref ID J:69121]

Elmer E; Kokaia M; Ernfors P; Ferencz I; Kokaia Z; Lindvall O. 1997. Suppressed kindling epileptogenesis and perturbed BDNF and TrkB gene regulation in NT-3 mutant mice. Exp Neurol 145(1):93-103. [PubMed: 9184113]  [MGI Ref ID J:40463]

Ernfors P; Kucera J; Lee KF; Loring J; Jaenisch R. 1995. Studies on the physiological role of brain-derived neurotrophic factor and neurotrophin-3 in knockout mice. Int J Dev Biol 39(5):799-807. [PubMed: 8645564]  [MGI Ref ID J:31400]

Ernfors P; Lee KF; Kucera J; Jaenisch R. 1994. Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell 77(4):503-12. [PubMed: 7514502]  [MGI Ref ID J:23882]

Ernfors P; Van De Water T; Loring J; Jaenisch R. 1995. Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron 14(6):1153-64. [PubMed: 7605630]  [MGI Ref ID J:26749]

Fan G; Copray S; Huang EJ; Jones K; Yan Q; Walro J; Jaenisch R; Kucera J. 2000. Formation of a full complement of cranial proprioceptors requires multiple neurotrophins. Dev Dyn 218(2):359-70. [PubMed: 10842362]  [MGI Ref ID J:62766]

Fan G; Jaenisch R; Kucera J. 1999. A role for p75 receptor in neurotrophin-3 functioning during the development of limb proprioception. Neuroscience 90(1):259-68. [PubMed: 10188952]  [MGI Ref ID J:53825]

Fan L; Girnius S; Oakley B. 2004. Support of trigeminal sensory neurons by nonneuronal p75 neurotrophin receptors. Brain Res Dev Brain Res 150(1):23-39. [PubMed: 15126035]  [MGI Ref ID J:90280]

Fundin BT; Silos-Santiago I; Ernfors P; Fagan AM; Aldskogius H ; DeChiara TM ; Phillips HS ; Barbacid M ; Yancopoulos GD ; Rice FL. 1997. Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR. Dev Biol 190(1):94-116. [PubMed: 9331334]  [MGI Ref ID J:43425]

Gacek RR; Khetarpal U. 1998. Neurotrophin 3, not brain-derived neurotrophic factor or neurotrophin 4, knockout mice have delay in vestibular compensation after unilateral labyrinthectomy. Laryngoscope 108(5):671-8. [PubMed: 9591544]  [MGI Ref ID J:113175]

Holm PC; Rodriguez FJ; Kresse A; Canals JM; Silos-Santiago I; Arenas E. 2003. Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons. Development 130(15):3535-45. [PubMed: 12810600]  [MGI Ref ID J:83661]

Kokaia M; Asztely F; Olofsdotter K; Sindreu CB; Kullmann DM; Lindvall O. 1998. Endogenous neurotrophin-3 regulates short-term plasticity at lateral perforant path-granule cell synapses. J Neurosci 18(21):8730-9. [PubMed: 9786980]  [MGI Ref ID J:50620]

Krimm RF; Davis BM; Albers KM. 2000. Cutaneous overexpression of neurotrophin-3 (NT3) selectively restores sensory innervation in NT3 gene knockout mice. J Neurobiol 43(1):40-9. [PubMed: 10756065]  [MGI Ref ID J:62390]

Kucera J; Fan G; Jaenisch R; Linnarsson S; Ernfors P. 1995. Dependence of developing group Ia afferents on neurotrophin-3. J Comp Neurol 363(2):307-20. [PubMed: 8642077]  [MGI Ref ID J:153797]

Kucera J; Fan G; Walro J; Copray S; Tessarollo L; Jaenisch R. 1998. Neurotrophin-3 and trkC in muscle are non-essential for the development of mouse muscle spindles. Neuroreport 9(5):905-9. [PubMed: 9579688]  [MGI Ref ID J:47110]

Liu X; Jaenisch R. 2000. Severe peripheral sensory neuron loss and modest motor neuron reduction in mice with combined deficiency of brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5. Dev Dyn 218(1):94-101. [PubMed: 10822262]  [MGI Ref ID J:62072]

McIlwrath SL; Hu J; Anirudhan G; Shin JB; Lewin GR. 2005. The sensory mechanotransduction ion channel ASIC2 (acid sensitive ion channel 2) is regulated by neurotrophin availability. Neuroscience 131(2):499-511. [PubMed: 15708491]  [MGI Ref ID J:105150]

Nosrat CA; Blomlof J; ElShamy WM; Ernfors P; Olson L. 1997. Lingual deficits in BDNF and NT3 mutant mice leading to gustatory and somatosensory disturbances, respectively. Development 124(7):1333-42. [PubMed: 9118804]  [MGI Ref ID J:40033]

Olofsdotter K; Lindvall O; Asztely F. 2000. Increased synaptic inhibition in dentate gyrus of mice with reduced levels of endogenous brain-derived neurotrophic factor. Neuroscience 101(3):531-9. [PubMed: 11113302]  [MGI Ref ID J:118727]

Parthasarathy S; Srivatsa S; Nityanandam A; Tarabykin V. 2014. Ntf3 acts downstream of Sip1 in cortical postmitotic neurons to control progenitor cell fate through feedback signaling. Development 141(17):3324-30. [PubMed: 25085976]  [MGI Ref ID J:214086]

Patel TD; Kramer I; Kucera J; Niederkofler V; Jessell TM; Arber S; Snider WD. 2003. Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents. Neuron 38(3):403-16. [PubMed: 12741988]  [MGI Ref ID J:83461]

Puehringer D; Orel N; Luningschror P; Subramanian N; Herrmann T; Chao MV; Sendtner M. 2013. EGF transactivation of Trk receptors regulates the migration of newborn cortical neurons. Nat Neurosci 16(4):407-15. [PubMed: 23416450]  [MGI Ref ID J:197463]

Raab M; Worl J; Brehmer A; Neuhuber WL. 2003. Reduction of NT-3 or TrkC results in fewer putative vagal mechanoreceptors in the mouse esophagus. Auton Neurosci 108(1-2):22-31. [PubMed: 14614961]  [MGI Ref ID J:102715]

Rice FL; Albers KM; Davis BM; Silos-Santiago I; Wilkinson GA; LeMaster AM; Ernfors P; Smeyne RJ; Aldskogius H; Phillips HS; Barbacid M; DeChiara TM; Yancopoulos GD; Dunne CE; Fundin BT. 1998. Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR. Dev Biol 198(1):57-81. [PubMed: 9640332]  [MGI Ref ID J:107715]

Robertson RT; Baratta J; Yu J; Guthrie KM. 2006. A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex. Neuroscience 143(2):523-39. [PubMed: 17049175]  [MGI Ref ID J:147256]

Sahenk Z; Oblinger J; Edwards C. 2008. Neurotrophin-3 deficient Schwann cells impair nerve regeneration. Exp Neurol 212(2):552-6. [PubMed: 18511043]  [MGI Ref ID J:137927]

Sedy J; Szeder V; Walro JM; Ren ZG; Nanka O; Tessarollo L; Sieber-Blum M; Grim M; Kucera J. 2004. Pacinian corpuscle development involves multiple Trk signaling pathways. Dev Dyn 231(3):551-63. [PubMed: 15376326]  [MGI Ref ID J:93853]

Sheard PW; Bewick GS; Woolley AG; Shaw J; Fisher L; Fong SW; Duxson MJ. 2010. Investigation of neuromuscular abnormalities in neurotrophin-3-deficient mice. Eur J Neurosci 31(1):29-41. [PubMed: 20092553]  [MGI Ref ID J:158365]

Sheard PW; Musaad K; Duxson MJ. 2002. Distribution of neurotrophin receptors in the mouse neuromuscular system. Int J Dev Biol 46(4):569-75. [PubMed: 12141445]  [MGI Ref ID J:100050]

Story GM; DiCarlo SE; Rodenbaugh DW; Dluzen DE; Kucera J; Maron MB; Walro JM. 2000. Inactivation of one copy of the mouse neurotrophin-3 gene induces cardiac sympathetic deficits Physiol Genomics 2(3):129-36. [PubMed: 11015591]  [MGI Ref ID J:62748]

Stucky CL; Shin JB; Lewin GR. 2002. Neurotrophin-4: a survival factor for adult sensory neurons. Curr Biol 12(16):1401-4. [PubMed: 12194821]  [MGI Ref ID J:78592]

Torres-Peraza J; Pezzi S; Canals JM; Gavalda N; Garcia-Martinez JM; Perez-Navarro E; Alberch J. 2007. Mice heterozygous for neurotrophin-3 display enhanced vulnerability to excitotoxicity in the striatum through increased expression of N-methyl-D-aspartate receptors. Neuroscience 144(2):462-71. [PubMed: 17081696]  [MGI Ref ID J:117952]

Woolley A; Sheard P; Dodds K; Duxson M. 1999. Alpha motoneurons are present in normal numbers but with reduced soma size in neurotrophin-3 knockout mice. Neurosci Lett 272(2):107-10. [PubMed: 10507553]  [MGI Ref ID J:59763]

Woolley AG; Sheard PW; Duxson MJ. 2005. Neurotrophin-3 null mutant mice display a postnatal motor neuropathy. Eur J Neurosci 21(8):2100-10. [PubMed: 15869506]  [MGI Ref ID J:101071]

Woolley AG; Tait KJ; Hurren BJ; Fisher L; Sheard PW; Duxson MJ. 2008. Developmental loss of NT-3 in vivo results in reduced levels of myelin-specific proteins, a reduced extent of myelination and increased apoptosis of Schwann cells. Glia 56(3):306-17. [PubMed: 18080292]  [MGI Ref ID J:156288]

Wright DE; Zhou L; Kucera J; Snider WD. 1997. Introduction of a neurotrophin-3 transgene into muscle selectively rescues proprioceptive neurons in mice lacking endogenous neurotrophin-3. Neuron 19(3):503-17. [PubMed: 9331344]  [MGI Ref ID J:43444]

Wyatt S; Pinon LG; Ernfors P; Davies AM. 1997. Sympathetic neuron survival and TrkA expression in NT3-deficient mouse embryos. EMBO J 16(11):3115-23. [PubMed: 9214629]  [MGI Ref ID J:41123]

Zhang C; Brandemihl A; Lau D; Lawton A; Oakley B. 1997. BDNF is required for the normal development of taste neurons in vivo. Neuroreport 8(4):1013-7. [PubMed: 9141083]  [MGI Ref ID J:40246]

elshamy WM; Ernfors P. 1996. Requirement of neurotrophin-3 for the survival of proliferating trigeminal ganglion progenitor cells. Development 122(8):2405-14. [PubMed: 8756286]  [MGI Ref ID J:34771]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   See control note: Wildtype mice from the colony may be used as controls. This strain is a mixture of 129S4/SvJae, BALB/c and C57BL/6J inbred strains.
   Wild-type from the colony
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.8)