Strain Name:

BTBR T+ Itpr3tf/J

Stock Number:

002282

Order this mouse

Availability:

Level 3


      Cell Line: BTBR T+ Itpr3tf/J-PB60.6 mES cells

This strain is used in studies of autism because it exhibits several symptoms of autism including: reduced social interactions, impaired play, low exploratory behavior, unusual vocalizations and high anxiety as compared to other inbred strains. BTBR mice exhibit a 100% absence of the corpus callosum and a severly reduced hippocampal commissure.

Description

Strain Information

Former Names BTBR T+ tf/J    (Changed: 30-OCT-12 )
Type Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Type Inbred Strain;
Additional information on Inbred Strains.
Visit our online Nomenclature tutorial.
Mating SystemSibling x Sibling         (Female x Male)   01-MAR-06
Breeding Considerations This strain is an exceptional breeder.
Specieslaboratory mouse
H2 Haplotypeb
GenerationF?+51 (05-AUG-14)
Generation Definitions

View larger image

Appearance
black and tan, tufted
Related Genotype: at/at T+/T+ Itpr3tf/Itpr3tf

Description
BTBR mice exhibit a 100% absence of the corpus callosum and a severly reduced hippocampal commissure (Wahlsten D, 2003 Brain Res). This strain exhibits several symptoms of autism including: reduced social interactions, impaired play, low exploratory behavior, unusual vocalizations and high anxiety as compared to other inbred strains (McFarlane HG, 2008, Gen, Brain Behav; Moy SS, 2007, Behav Br Res, Scattoni ML, 2008, PLos).

Development
The BTBR T+ Itpr3tf/J strain was derived from the inbred strain BTBR (Black and Tan BRachyury) that carried the mutations at(nonagouti; black and tan), Itpr3tf (inositol 1,4,5-triphosphate receptor 3; tufted), and T (brachyury). The BTBR strain was developed by L.C. Dunn from stock obtained from Dobrovolskaia-Zavadskaia. He brother-sister mated the stock at Columbia University and inserted tufted (Itpr3tf) as a marker around 1956. The stock was continuously inbred in the laboratory of the late Dorothea Bennett from 1962 and then brought by Karen Atrzt in 1974 from the Bennett laboratory to the laboratory of Jean-Louis Guenet at the Institut Pasteur, who sent the strain in 1982 to the McArdle Laboratory at the University of Wisconsin. The T locus had been maintained in the strain as a segregating locus, but had been dropped sometime prior to the acquisition of the current strain by The Jackson Laboratory from Alexandra Shedlovsky and Bill Dove at the McArdle Laboratory in 1994.

Related Strains

Strains carrying   Disc1del allele
001137   129P1/ReJ
000690   129P3/J
001198   129P4/RrRkJ
002448   129S1/SvImJ
002064   129T2/SvEms
002065   129T2/SvEmsJ
000691   129X1/SvJ
002243   DDY/JclSidSeyFrkJ
001800   FVB/NJ
000676   LP/J
000686   SJL/J
000689   SWR/J
View Strains carrying   Disc1del     (12 strains)

View Strains carrying   Itpr3tf     (5 strains)

Strains carrying   T+ allele
016926   BTBR T+ Itpr3tf-Fbxl3Ovtm/J
View Strains carrying   T+     (1 strain)

Strains carrying other alleles of Itpr3
013147   STOCK Itpr3tm1.1Rmnc/Mmjax
View Strains carrying other alleles of Itpr3     (1 strain)

View Strains carrying other alleles of T     (15 strains)

Additional Web Information

JAX® NOTES, Winter 2006; 504. JAX® Mice: the Gold Standard Just Got Better.
JAX® NOTES, Winter 2008; 512. JAX® Mice strain sheds new light on autism.

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data
Mouse Phenome Database
View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Diabetes Mellitus, Insulin-Dependent; IDDM   (ITPR3)
Schizophrenia 9; SCZD9   (DISC1)
Schizophrenia; SCZD   (DISC1)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Itpr3tf/Itpr3tf

        involves: BTBR
  • integument phenotype
  • abnormal coat/ hair morphology
    • detectable about 4 weeks of age   (MGI Ref ID J:273)
    • alternating waves of hair loss and growth are repeated throughout the life of the mouse   (MGI Ref ID J:273)
    • abnormal hair growth   (MGI Ref ID J:273)
      • sparse hair
        • waves of hair loss and growth create a sparse hair appearance anterior to posterior, ventral and dorsal   (MGI Ref ID J:273)
  • abnormal hair cycle
    • a wave of hair loss begins ventrally under the jaw and spreads posteriorly   (MGI Ref ID J:273)
    • a few days after ventral hair loss a similar dorsal wave of hair loss begins at the face, not including whiskers   (MGI Ref ID J:273)
    • a normal wave of hair growth follows the initial loss pattern   (MGI Ref ID J:273)
  • behavior/neurological phenotype
  • abnormal liquid preference
    • in a 48 h two-bottle choice test, mice exhibit higher preference for calcium chloride, calcium lactate, denatorium, quinine hydrochloride and caffeine compared with NZW mice   (MGI Ref ID J:201643)
    • in a 48 h two-bottle choice test, mice exhibit lower preference for sodium chloride, inosine monophosphate, trisodium pyrophosphate, saccharin, sucrose and hydrochloride compared with NZW mice   (MGI Ref ID J:201643)
    • in a 96 h two-bottle choice tests, mice exhibit higher preference for calcium chloride and calcium lactate compared with NZW mice   (MGI Ref ID J:201643)
    • in a 96 h two-bottle choice tests, mice exhibit lower preference for saccharin and citric acid compared with NZW mice   (MGI Ref ID J:201643)
    • however, mice exhibit normal response to capsaicin   (MGI Ref ID J:201643)
  • increased fluid intake
    • compared with NZW mice   (MGI Ref ID J:201643)
  • low sweet preference
    • in a 48 h two-bottle choice test, mice exhibit lower preference for saccharin and sucrose compared with NZW mice   (MGI Ref ID J:201643)
    • in a 96 h two-bottle choice tests, mice exhibit lower preference for saccharin compared with NZW mice   (MGI Ref ID J:201643)
  • growth/size/body phenotype
  • increased body weight
    • male, but not female, mice exhibit a slight increase in body weight compared with NZW mice   (MGI Ref ID J:201643)
  • taste/olfaction phenotype
  • abnormal gustatory system physiology
    • in a 48 h two-bottle choice test, mice exhibit higher preference for calcium chloride, calcium lactate, denatorium, quinine hydrochloride and caffeine compared with NZW mice   (MGI Ref ID J:201643)
    • in a 48 h two-bottle choice test, mice exhibit lower preference for sodium chloride, inosine monophosphate, trisodium pyrophosphate, saccharin, sucrose and hydrochloride compared with NZW mice   (MGI Ref ID J:201643)
    • in a 96 h two-bottle choice tests, mice exhibit higher preference for calcium chloride and calcium lactate compared with NZW mice   (MGI Ref ID J:201643)
    • in a 96 h two-bottle choice tests, mice exhibit lower preference for saccharin and citric acid compared with NZW mice   (MGI Ref ID J:201643)
    • however, mice exhibit normal response to capsaicin   (MGI Ref ID J:201643)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Dermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects

Developmental Biology Research
Neurodevelopmental Defects
      acallosal

Neurobiology Research
Neurodevelopmental Defects
      Autism
      acallosal

Itpr3tf related

Dermatology Research
Skin and Hair Texture Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Itpr3tf
Allele Name tufted
Allele Type Spontaneous
Common Name(s) tf;
Strain of OriginBTBR
Gene Symbol and Name Itpr3, inositol 1,4,5-triphosphate receptor 3
Chromosome 17
Gene Common Name(s) IP3R; IP3R3; IP3R3X; Ip3r3; Itpr-3; inositol 1,4,5-triphosphate receptor, type III; tf; tufted;
General Note This allele was recovered from a Harwell testing stock carrying multiple recessive markers in an undefined background. (J:273)
Molecular Note Complementation mapping was used to demonstrate that this spontaneous mutation was an allele of Itpr3. Sequencing revealed a 12 bp deletion in Exon23 (Chr17: 27238069, Build 38.1) which codes for amino acids 983-986. This mutation arose early in the history of the BTBR strain (in or soon after 1956) and is not found in 18 other strains (129P2/OlaHsd, 129S1/SvImJ, 129S5/SvEvBrd, A/J, AKR/J, BALB/cJ, C3H/HeJ, C57BL/6NJ, CAST/EiJ, CBA/J, DBA/2J, FVB/NJ, LP/J, NOD/ShiLtJ, NZO/HlLtJ, PWK/PhJ, SPRET/EiJ and WSB/EiJ) [MGI Ref ID J:188251] [MGI Ref ID J:201643]
 
Allele Symbol T+
Allele Name wild type
Allele Type Not Applicable
Gene Symbol and Name T, brachyury
Chromosome 17
Gene Common Name(s) Bra; Low; Lr; T1; Tl2; Tl3; brachyury-like 2; brachyury-like 3; cou; coupe; low ratio;
 
Allele Symbol Disc1del
Allele Name deletion
Allele Type Spontaneous
Common Name(s) Disc1129S6; Disc1delta6;
Strain of Originvarious
Gene Symbol and Name Disc1, disrupted in schizophrenia 1
Chromosome 8
Gene Common Name(s) C1orf136; SCZD9;
General Note This deletion appears in multiple strains of the 129 superfamily, 101/RI, BTBR T+ tf/J, LP/J, FVB/NJ, SJL/J, SWR/J and DDY/JclSidSeyFrkJ (J:111837, J:195189).
Molecular Note A 25 bp deletion of the locus causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon at exon 7. [MGI Ref ID J:107244]

Genotyping

Genotyping Information

Genotyping Protocols

Itpr3tfEnd Point, End Point Analysis

Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Disc1del related

Clapcote SJ; Roder JC. 2006. Deletion polymorphism of disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function. Genetics 173(4):2407-10. [PubMed: 16751659]  [MGI Ref ID J:111837]

Clapcote SJ; Roder JC. 2007. Inbred mouse strains 101/RI, BTBR T tf/J and LP/J have a deletion in Disc1 MGI Direct Data Submission :.  [MGI Ref ID J:118317]

Koike H; Arguello PA; Kvajo M; Karayiorgou M; Gogos JA. 2006. Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc Natl Acad Sci U S A 103(10):3693-7. [PubMed: 16484369]  [MGI Ref ID J:107244]

Kuroda K; Yamada S; Tanaka M; Iizuka M; Yano H; Mori D; Tsuboi D; Nishioka T; Namba T; Iizuka Y; Kubota S; Nagai T; Ibi D; Wang R; Enomoto A; Isotani-Sakakibara M; Asai N; Kimura K; Kiyonari H; Abe T; Mizoguchi A; Sokabe M; Takahashi M; Yamada K; Kaibuchi K. 2011. Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. Hum Mol Genet 20(23):4666-83. [PubMed: 21903668]  [MGI Ref ID J:177560]

Ritchie D; Clapcote S. 2013. Disc1 deletion is present in Swiss-derived inbred mouse strains: implications for transgenic studies of learning and memory. Lab Anim :. [PubMed: 23563120]  [MGI Ref ID J:195189]

Zou H; Yu Y; Sheikh AM; Malik M; Yang K; Wen G; Chadman KK; Brown WT; Li X. 2011. Association of upregulated Ras/Raf/ERK1/2 signaling with autism. Genes Brain Behav 10(5):615-24. [PubMed: 21595826]  [MGI Ref ID J:185685]

Itpr3tf related

Amodeo DA; Jones JH; Sweeney JA; Ragozzino ME. 2012. Differences in BTBR T+ tf/J and C57BL/6J mice on probabilistic reversal learning and stereotyped behaviors. Behav Brain Res 227(1):64-72. [PubMed: 22056750]  [MGI Ref ID J:180186]

Borthwell RM; Hunsaker MR; Willemsen R; Berman RF. 2012. Spatiotemporal processing deficits in female CGG KI mice modeling the fragile X premutation. Behav Brain Res 233(1):29-34. [PubMed: 22561129]  [MGI Ref ID J:190501]

Crabbe JC; Cotnam CJ; Cameron AJ; Schlumbohm JP; Rhodes JS; Metten P; Wahlsten D. 2003. Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests. Genes Brain Behav 2(4):201-13. [PubMed: 12953786]  [MGI Ref ID J:104878]

Defensor EB; Pearson BL; Pobbe RL; Bolivar VJ; Blanchard DC; Blanchard RJ. 2011. A novel social proximity test suggests patterns of social avoidance and gaze aversion-like behavior in BTBR T+ tf/J mice. Behav Brain Res 217(2):302-8. [PubMed: 21055421]  [MGI Ref ID J:167352]

Ellis HT; Tordoff MG; Parker MR. 2012. Itpr3 Is Responsible for the Mouse Tufted (tf) Locus. J Hered :. [PubMed: 23100490]  [MGI Ref ID J:188251]

Han S; Tai C; Jones CJ; Scheuer T; Catterall WA. 2014. Enhancement of inhibitory neurotransmission by GABAA receptors having alpha2,3-subunits ameliorates behavioral deficits in a mouse model of autism. Neuron 81(6):1282-9. [PubMed: 24656250]  [MGI Ref ID J:213173]

Heo Y; Zhang Y; Gao D; Miller VM; Lawrence DA. 2011. Aberrant immune responses in a mouse with behavioral disorders. PLoS One 6(7):e20912. [PubMed: 21799730]  [MGI Ref ID J:174928]

Karunakaran S; Manji A; Yan CS; Wu ZJ; Clee SM. 2013. Moo1 obesity quantitative trait locus in BTBR T+ Itpr3tf/J mice increases food intake. Physiol Genomics 45(5):191-9. [PubMed: 23341217]  [MGI Ref ID J:195220]

Kusek GK; Wahlsten D; Herron BJ; Bolivar VJ; Flaherty L. 2007. Localization of two new X-linked quantitative trait loci controlling corpus callosum size in the mouse. Genes Brain Behav 6(4):359-63. [PubMed: 16899052]  [MGI Ref ID J:137289]

Lyon MF. 1996. An additional type of male sterility and inherited urinary obstruction in mice with the t-haplotype th7. Genet Res 67(3):249-56. [PubMed: 8690273]  [MGI Ref ID J:34190]

Lyon MF. 1956. Hereditary hair loss in the tufted mutant of the house mouse J Hered 47:101-3.  [MGI Ref ID J:273]

Lyon MF; Bechtol KB. 1977. Derivation of mutant t-haplotypes of the mouse by presumed duplication or deletion. Genet Res 30(1):63-76. [PubMed: 924142]  [MGI Ref ID J:5889]

MacPherson P; McGaffigan R; Wahlsten D; Nguyen PV. 2008. Impaired fear memory, altered object memory and modified hippocampal synaptic plasticity in split-brain mice. Brain Res 1210:179-88. [PubMed: 18417102]  [MGI Ref ID J:136821]

McFarlane HG; Kusek GK; Yang M; Phoenix JL; Bolivar VJ; Crawley JN. 2008. Autism-like behavioral phenotypes in BTBR T+tf/J mice. Genes Brain Behav 7(2):152-63. [PubMed: 17559418]  [MGI Ref ID J:138842]

Mercier F; Cho Kwon Y; Kodama R. 2011. Meningeal/vascular alterations and loss of extracellular matrix in the neurogenic zone of adult BTBR T+ tf/J mice, animal model for autism. Neurosci Lett 498(3):173-8. [PubMed: 21600960]  [MGI Ref ID J:174319]

Mercier F; Kwon YC; Douet V. 2012. Hippocampus/amygdala alterations, loss of heparan sulfates, fractones and ventricle wall reduction in adult BTBR T+ tf/J mice, animal model for autism. Neurosci Lett 506(2):208-13. [PubMed: 22100909]  [MGI Ref ID J:180372]

Meyza KZ; Blanchard DC; Pearson BL; Pobbe RL; Blanchard RJ. 2012. Fractone-associated N-sulfated heparan sulfate shows reduced quantity in BTBR T+tf/J mice: a strong model of autism. Behav Brain Res 228(2):247-53. [PubMed: 22101175]  [MGI Ref ID J:181751]

MouseBookTM. 2005. Information obtained from MouseBook<sup>TM</sup>, Medical Research Council Mammalian Genetics Unit, Harwell, UK. Unpublished :.  [MGI Ref ID J:169366]

Pearson BL; Bettis JK; Meyza KZ; Yamamoto LY; Blanchard DC; Blanchard RJ. 2012. Absence of social conditioned place preference in BTBR T+tf/J mice: relevance for social motivation testing in rodent models of autism. Behav Brain Res 233(1):99-104. [PubMed: 22562042]  [MGI Ref ID J:190500]

Pearson BL; Pobbe RL; Defensor EB; Oasay L; Bolivar VJ; Blanchard DC; Blanchard RJ. 2011. Motor and cognitive stereotypies in the BTBR T+tf/J mouse model of autism. Genes Brain Behav 10(2):228-35. [PubMed: 21040460]  [MGI Ref ID J:183514]

Rutz HL; Rothblat LA. 2012. Intact and impaired executive abilities in the BTBR mouse model of autism. Behav Brain Res 234(1):33-7. [PubMed: 22677272]  [MGI Ref ID J:190470]

Sato-Miyaoka M; Hisatsune C; Ebisui E; Ogawa N; Takahashi-Iwanaga H; Mikoshiba K. 2012. Regulation of hair shedding by the type 3 IP3 receptor. J Invest Dermatol 132(9):2137-47. [PubMed: 22572820]  [MGI Ref ID J:188252]

Scattoni ML; Gandhy SU; Ricceri L; Crawley JN. 2008. Unusual repertoire of vocalizations in the BTBR T+tf/J mouse model of autism. PLoS ONE 3(8):e3067. [PubMed: 18728777]  [MGI Ref ID J:138605]

Scattoni ML; Ricceri L; Crawley JN. 2011. Unusual repertoire of vocalizations in adult BTBR T+tf/J mice during three types of social encounters. Genes Brain Behav 10(1):44-56. [PubMed: 20618443]  [MGI Ref ID J:183525]

Silver LM; Cisek L; Jackson C; Lukralle D. 1985. A new spontaneous mutation at the tufted locus within a mouse t haplotype. Genet Res 45(1):107-12. [PubMed: 3996911]  [MGI Ref ID J:7861]

Silverman JL; Smith DG; Rizzo SJ; Karras MN; Turner SM; Tolu SS; Bryce DK; Smith DL; Fonseca K; Ring RH; Crawley JN. 2012. Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism. Sci Transl Med 4(131):131ra51. [PubMed: 22539775]  [MGI Ref ID J:183984]

Silverman JL; Yang M; Turner SM; Katz AM; Bell DB; Koenig JI; Crawley JN. 2010. Low stress reactivity and neuroendocrine factors in the BTBR T+tf/J mouse model of autism. Neuroscience 171(4):1197-208. [PubMed: 20888890]  [MGI Ref ID J:170182]

Tordoff MG; Ellis HT. 2013. Taste dysfunction in BTBR mice due to a mutation of Itpr3, the inositol triphosphate receptor 3 gene. Physiol Genomics 45(18):834-55. [PubMed: 23859941]  [MGI Ref ID J:201643]

Wohr M; Roullet FI; Crawley JN. 2011. Reduced scent marking and ultrasonic vocalizations in the BTBR T+tf/J mouse model of autism. Genes Brain Behav 10(1):35-43. [PubMed: 20345893]  [MGI Ref ID J:183527]

Yang M; Clarke AM; Crawley JN. 2009. Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability. Eur J Neurosci 29(8):1663-77. [PubMed: 19419429]  [MGI Ref ID J:148483]

Zou H; Yu Y; Sheikh AM; Malik M; Yang K; Wen G; Chadman KK; Brown WT; Li X. 2011. Association of upregulated Ras/Raf/ERK1/2 signaling with autism. Genes Brain Behav 10(5):615-24. [PubMed: 21595826]  [MGI Ref ID J:185685]

T+ related

Abe K; Yamamura K; Suzuki M. 2000. Molecular and embryological characterization of a new transgene-induced null allele of mouse Brachyury locus. Mamm Genome 11(3):238-40. [PubMed: 10723731]  [MGI Ref ID J:60706]

Babiarz B; Garrisi GJ; Bennett D. 1982. Genetic analysis of the tw73 haplotype of the mouse using deletion mutations: evidence for a parasitic lethal mutation. Genet Res 39(2):111-20. [PubMed: 7084665]  [MGI Ref ID J:175674]

Bilinski P; Schimenti J; Gossler A. 1997. A new spontaneous deletion on chromosome 17 including brachyury. Mamm Genome 8(12):932-3. [PubMed: 9383288]  [MGI Ref ID J:44446]

Bogani D; Siggers P; Brixey R; Warr N; Beddow S; Edwards J; Williams D; Wilhelm D; Koopman P; Flavell RA; Chi H; Ostrer H; Wells S; Cheeseman M; Greenfield A. 2009. Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. PLoS Biol 7(9):e1000196. [PubMed: 19753101]  [MGI Ref ID J:153050]

Bogani D; Warr N; Elms P; Davies J; Tymowska-Lalanne Z; Goldsworthy M; Cox RD; Keays DA; Flint J; Wilson V; Nolan P; Arkell R. 2004. New semidominant mutations that affect mouse development. Genesis 40(2):109. [PubMed: 15384171]  [MGI Ref ID J:93195]

Bucan M; Herrmann BG; Frischauf AM; Bautch VL; Bode V; Silver LM; Martin GR; Lehrach H. 1987. Deletion and duplication of DNA sequences is associated with the embryonic lethal phenotype of the t9 complementation group of the mouse t complex. Genes Dev 1(4):376-85. [PubMed: 3678828]  [MGI Ref ID J:8922]

Cattanach BM; Raspberry C. 1987. A new curtailed mutation Mouse News Lett 77:122.  [MGI Ref ID J:85396]

Chao HH; Mentzer SE; Schimenti JC; You Y. 2003. Overlapping deletions define novel embryonic lethal loci in the mouse t complex. Genesis 35(2):133-42. [PubMed: 12533796]  [MGI Ref ID J:81651]

Dionne L; Fairfield HE; Bergstrom DE; Donahue LR. 2012. Brachyury 11 Jackson MGI Direct Data Submission :.  [MGI Ref ID J:187215]

Dunn LC; Bennett D. 1971. Lethal alleles near locus T in the house mouse population on the Jutland Peninsula, Denmark Evolution 25(3):451-53.  [MGI Ref ID J:175677]

Dunn LC; Gluecksohn-Waelsch S. 1953. Genetic Analysis of Seven Newly Discovered Mutant Alleles at Locus T in the House Mouse. Genetics 38(3):261-71. [PubMed: 17247438]  [MGI Ref ID J:36683]

Dunn LC; Suckling J. 1956. Studies of the Genetic Variability in Wild Populations of House Mice. I. Analysis of Seven Alleles at Locus T. Genetics 41(3):344-52. [PubMed: 17247632]  [MGI Ref ID J:23652]

Fujimoto A; Baba N; Wakasugi N. 1991. A tail length modifier gene discovered in the Japanese wild mice (Mus musculus molossinus). Jpn J Genet 66(2):141-54. [PubMed: 1859671]  [MGI Ref ID J:14919]

Fujimoto A; Wakasugi N; Tomita T. 1994. The developmental and morphological studies on the neural and skeletal abnormalities in the t/btm tailless mice. Dev Growth Differ 36(4):409-417.  [MGI Ref ID J:21054]

Guenet JL; Condamine H; Gaillard J; Jacob F. 1980. twPa-1, twPa-2, twPa-3: three new t-haplotypes in the mouse. Genet Res 36(2):211-7. [PubMed: 7461454]  [MGI Ref ID J:6461]

Harris BS; Ward-Bailey PF. 2001. Identification and Mapping of the brachyury-like 2 mouse mutant MGI Direct Data Submission :.  [MGI Ref ID J:72463]

Harris BS; Ward-Bailey PF. 2001. Identification and Mapping of the brachyury-like 3 mouse mutant MGI Direct Data Submission :.  [MGI Ref ID J:72464]

Harrison SM; Houzelstein D; Dunwoodie SL; Beddington RS. 2000. Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with brachyury Dev Biol 227(2):358-72. [PubMed: 11071760]  [MGI Ref ID J:65743]

Imuta Y; Kiyonari H; Jang CW; Behringer RR; Sasaki H. 2013. Generation of knock-in mice that express nuclear enhanced green fluorescent protein and tamoxifen-inducible Cre recombinase in the notochord from Foxa2 and T loci. Genesis 51(3):210-8. [PubMed: 23359409]  [MGI Ref ID J:194054]

Johnson DR. 1974. Further observations on the haipin-tail (Thp) mutation in the mouse. Genet Res 24(2):207-13. [PubMed: 4452482]  [MGI Ref ID J:5522]

Johnson DR. 1974. Hairpin-tail: a case of post-reductional gene action in the mouse egg. Genetics 76(4):795-805. [PubMed: 4838760]  [MGI Ref ID J:31524]

Katoh H. 1989. Semidominant short tail (T<Jic>) Mouse News Lett 84:94-95.  [MGI Ref ID J:14257]

Lyon MF. 1959. A new dominant T-allele in the house mouse. J Hered 50:140-142.  [MGI Ref ID J:13072]

Lyon MF. 1996. An additional type of male sterility and inherited urinary obstruction in mice with the t-haplotype th7. Genet Res 67(3):249-56. [PubMed: 8690273]  [MGI Ref ID J:34190]

Lyon MF. 1990. Search for differences among t haplotypes in distorter and responder genes. Genet Res 55(1):13-9. [PubMed: 2318411]  [MGI Ref ID J:192386]

Lyon MF. 1984. Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus. Cell 37(2):621-8. [PubMed: 6722884]  [MGI Ref ID J:7443]

Lyon MF; Bechtol KB. 1977. Derivation of mutant t-haplotypes of the mouse by presumed duplication or deletion. Genet Res 30(1):63-76. [PubMed: 924142]  [MGI Ref ID J:5889]

Lyon MF; Schimenti JC; Evans EP. 2000. Narrowing the critical regions for mouse t complex transmission ratio distortion factors by use of deletions Genetics 155(2):793-801. [PubMed: 10835400]  [MGI Ref ID J:62655]

Lyon MF; Zenthon J. 1987. Differences in or near the responder region of complete and partial mouse t-haplotypes. Genet Res 50(1):29-34. [PubMed: 3653686]  [MGI Ref ID J:183153]

MouseBookTM. 2005. Information obtained from MouseBook<sup>TM</sup>, Medical Research Council Mammalian Genetics Unit, Harwell, UK. Unpublished :.  [MGI Ref ID J:169366]

Moutier R. 1973. t Mouse News Lett 49:42.  [MGI Ref ID J:15078]

Nolan PM; Peters J; Strivens M; Rogers D; Hagan J; Spurr N; Gray IC; Vizor L; Brooker D; Whitehill E; Washbourne R; Hough T; Greenaway S; Hewitt M; Liu X; McCormack S; Pickford K; Selley R; Wells C; Tymowska-Lalanne Z; Roby P; Glenister P; Thornton C; Thaung C; Stevenson JA; Arkell R; Mburu P; Hardisty R; Kiernan A; Erven A; Steel KP; Voegeling S; Guenet JL; Nickols C; Sadri R; Nasse M; Isaacs A; Davies K; Browne M; Fisher EM; Martin J; Rastan S; Brown SD; Hunter J. 2000. A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet 25(4):440-3. [PubMed: 10932191]  [MGI Ref ID J:63816]

Ruvinsky A; Polyakov A; Agulnik A; Tichy H; Figueroa F; Klein J. 1991. Low diversity of t haplotypes in the eastern form of the house mouse, Mus musculus L. Genetics 127(1):161-8. [PubMed: 2016041]  [MGI Ref ID J:32745]

Searle AG. 1966. Curtailed, a new dominant T-allele in the house mouse. Genet Res 7(1):86-95. [PubMed: 5906493]  [MGI Ref ID J:5003]

Searle AG. 1960. T<c> - curtailed Mouse News Lett 22:29.  [MGI Ref ID J:64262]

Shedlovsky A; King TR; Dove WF. 1988. Saturation germ line mutagenesis of the murine t region including a lethal allele at the quaking locus. Proc Natl Acad Sci U S A 85(1):180-4. [PubMed: 3422415]  [MGI Ref ID J:9032]

Silver LM; Artzt K. 1981. Recombination suppression of mouse t-haplotypes due to chromatin mismatching. Nature 290(5801):68-70. [PubMed: 7207588]  [MGI Ref ID J:6478]

Stott D; Kispert A; Herrmann BG. 1993. Rescue of the tail defect of Brachyury mice. Genes Dev 7(2):197-203. [PubMed: 8436292]  [MGI Ref ID J:3956]

Styrna J; Klein J. 1981. Evidence for two regions in the mouse t complex controlling transmission ratios. Genet Res 38(3):315-25. [PubMed: 7333459]  [MGI Ref ID J:6700]

Sweet HO; Davisson MT. 1995. Remutations at The Jackson Laboratory (Update to Mouse Genome 1993; 91:862-5 - J16313) Mouse Genome 93(4):1030-4.  [MGI Ref ID J:30778]

The Jackson Laboratory Office of Genetic Resources. 1987. Registry of Remutations at The Jackson Laboratory, 1987-1988 MGI Direct Data Submission :.  [MGI Ref ID J:78379]

The Jackson Laboratory Office of Genetic Resources. 1989. Registry of Remutations at The Jackson Laboratory, 1989-1990 MGI Direct Data Submission :.  [MGI Ref ID J:78380]

The Jackson Laboratory Office of Genetic Resourses. 1979. Registry of Remutations at The Jackson Laboratory, 1979-1980 MGI Direct Data Submission :.  [MGI Ref ID J:78474]

The RIKEN BioResource Center. 2006. Information obtained from The RIKEN BioResource Center Unpublished :.  [MGI Ref ID J:104881]

Vojtiskova M; Viklicky V; Voracova B; Lewis SE; Gluecksohn-Waelsch S. 1976. The effects of a t-allele (tAE5) in the mouse on the lymphoid system and reproduction. J Embryol Exp Morphol 36(2):443-51. [PubMed: 1003081]  [MGI Ref ID J:83862]

Washburn LL; Albrecht KH; Eicher EM. 2001. C57BL/6J-T-Associated Sex Reversal in Mice Is Caused by Reduced Expression of a Mus domesticus Sry Allele. Genetics 158(4):1675-81. [PubMed: 11514455]  [MGI Ref ID J:71077]

Washburn LL; Lee BK; Eicher EM. 1990. Inheritance of T-associated sex reversal in mice. Genet Res 56(2-3):185-91. [PubMed: 2272509]  [MGI Ref ID J:10943]

Wu B; Shao Y; Chen B; Liu C; Xue Z; Wu P; Li H. 2010. Identification of a novel mouse brachyury (T) allele causing a short tail mutation in mice. Cell Biochem Biophys 58(3):129-35. [PubMed: 20809182]  [MGI Ref ID J:166619]

Wutz A; Theussl HC; Dausman J; Jaenisch R; Barlow DP; Wagner EF. 2001. Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice. Development 128(10):1881-7. [PubMed: 11311167]  [MGI Ref ID J:68721]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX8

Colony Maintenance

Mating SystemSibling x Sibling         (Female x Male)   01-MAR-06
Breeding Considerations This strain is an exceptional breeder.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)Gender
3 weeks $84.90Female or Male  
4 weeks $84.90Female or Male  
5 weeks $84.90Female or Male  
6 weeks $87.55Female or Male  
7 weeks $90.20Female or Male  
8 weeks $92.85Female or Male  
9 weeks $95.50Female or Male  
10 weeks $98.15Female or Male  

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.

JAX® Cells, Tissues & Products

Select the cell line of interest to go to the cell line data sheet
BTBR T+ Itpr3tf/J-PB60.6 mES cells
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)Gender
3 weeks $110.40Female or Male  
4 weeks $110.40Female or Male  
5 weeks $110.40Female or Male  
6 weeks $113.90Female or Male  
7 weeks $117.30Female or Male  
8 weeks $120.80Female or Male  
9 weeks $124.20Female or Male  
10 weeks $127.60Female or Male  

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.

JAX® Cells, Tissues & Products

Select the cell line of interest to go to the cell line data sheet
BTBR T+ Itpr3tf/J-PB60.6 mES cells
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.8)