Description

Strain Information

Type Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling         (Female x Male)   01-MAR-06 Species laboratory mouse H2 Haplotype b Generation F?+34 (11-JAN-08)

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Appearance
black and tan, tufted
Related Genotype: a^t/a^t T⁺/T⁺ tf/tf

Description
BTBR mice exhibit a 100% absence of the corpus callosum and a severly reduced hippocampal commissure (Wahlsten D, 2003 Brain Res). This strain exhibits several symptoms of autism including: reduced social interactions, impaired play, low exploratory behavior, unusual vocalizations and high anxiety as compared to other inbred strains (McFarlane HG, 2008, Gen, Brain Behav; Moy SS, 2007, Behav Br Res, Scattoni ML, 2008, PLos).

Related Strains

Strains carrying   Disc1^del allele

001137	129P1/ReJ
000690	129P3/J
001198	129P4/RrRkJ
002448	129S1/SvImJ
002064	129T2/SvEms
002065	129T2/SvEmsJ
000691	129X1/SvJ
000676	LP/J

View Strains carrying   Disc1^del     (8 strains)

Strains carrying   tf allele

003879	B10;TFLe-a/a T tf/+ tf/J
001518	B6 x STOCK T tf/th45 tf/J
001874	STOCK tw82 tf/J
000588	TF/GnLe-T(1;17)190Ca +/+ tf/J

View Strains carrying   tf     (4 strains)

Strains carrying other alleles of T

003879	B10;TFLe-a/a T tf/+ tf/J
000405	B10ScSn.Cg-T/J
004591	B6 x B6Ei.Cg-TWis/EiJ
000953	B6 x BALB/cBy-T4J/J
001518	B6 x STOCK T tf/th45 tf/J
000567	B6.Cg-T2J +/+ Qkqk/J
001015	B6.Cg-T4Or/J
001054	B6.Cg-TOrl/EiJ
000350	B6By.Cg-KitW-v MitfMi-wh T/J
001053	C3Sn.AK-Thp/EiJ
000545	C57BL/6J-T2J/J
001199	C57BL/6J-T5J/J
001961	C57BL/6JEi x STOCK T T(16;17)43H/+ T(16;17)43H/Ei
001814	STOCK Tc/J

View Strains carrying other alleles of T     (14 strains)

Additional Web Information

Genetic Quality Control Annual Report
JAX^® NOTES, Winter 2006; 504. JAX^® Mice: the Gold Standard Just Got Better.
JAX^® NOTES, Winter 2008; 512. JAX^® Mice strain sheds new light on autism.

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Mouse Phenome Database

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

tf/tf

        Background Not Specified

• skin/coat/nails phenotype
• abnormal coat/ hair morphology (MGI Ref ID J:273)
  • detectable about 4 weeks of age
  • alternating waves of hair loss and growth are repeated throughout the life of the mouse
• abnormal hair growth (MGI Ref ID J:273)
• abnormal hair cycle (MGI Ref ID J:273)
  • a wave of hair loss begins ventrally under the jaw and spreads posteriorly
  • a few days after ventral hair loss a similar dorsal wave of hair loss begins at the face, not including whiskers
  • a normal wave of hair growth follows the initial loss pattern
• sparse hair (MGI Ref ID J:273)
  • waves of hair loss and growth create a sparse hair appearance anterior to posterior, ventral and dorsal

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Dermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects

Developmental Biology Research
Neurodevelopmental Defects
      acallosal

Neurobiology Research
Neurodevelopmental Defects
      Autism
      acallosal

tf related

Dermatology Research
Skin and Hair Texture Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol		T+
Allele Name		wild type
Allele Type		Not Specified
Gene Symbol and Name		T, brachyury
Chromosome		17
Gene Common Name(s)		Bra; Low; Lr; MGC104817; T1; TFT; Tl2; Tl3; brachyury-like 2; brachyury-like 3; cou; coupe; low ratio; me75;
Allele Symbol		tf
Allele Name		tufted
Allele Type		Spontaneous
Gene Symbol and Name		tf, tufted
Chromosome		17
Allele Symbol		Disc1del
Allele Name		deletion
Allele Type		Spontaneous
Common Name(s)		Disc1129S6;
Strain of Origin		various
Gene Symbol and Name		Disc1, disrupted in schizophrenia 1
Chromosome		8
Gene Common Name(s)		C1orf136; FLJ13381; FLJ21640; FLJ25311; FLJ41105; KIAA0457; SCZD9;
General Note		This deletion appears in multiple strains of the 129 superfamily. See J:111837 for details. This deletion has further been identified in the following strains:101/RI, BTBR T+ tf/J and LP/J J:118317
Molecular Note		A 25 bp deletion of the locus causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon at exon 7. [MGI Ref ID J:107244]

Genotyping

Genotyping Information

Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.

Helpful Links

Genotyping resources and troubleshooting

References

References

Additional References

Clapcote SJ; Roder JC. 2007. Inbred mouse strains 101/RI, BTBR T tf/J and LP/J have a deletion in Disc1 MGI Direct Data Submission :.  [MGI Ref ID J:118317]

McFarlane HG; Kusek GK; Yang M; Phoenix JL; Bolivar VJ; Crawley JN. 2008. Autism-like behavioral phenotypes in BTBR T+tf/J mice. Genes Brain Behav 7(2):152-63. [PubMed: 17559418]  [MGI Ref ID J:138842]

Moy SS; Nadler JJ; Young NB; Perez A; Holloway LP; Barbaro RP; Barbaro JR; Wilson LM; Threadgill DW; Lauder JM; Magnuson TR; Crawley JN. 2007. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res 176(1):4-20. [PubMed: 16971002]  [MGI Ref ID J:138682]

Scattoni ML; Gandhy SU; Ricceri L; Crawley JN. 2008. Unusual repertoire of vocalizations in the BTBR T+tf/J mouse model of autism. PLoS ONE 3(8):e3067. [PubMed: 18728777]  [MGI Ref ID J:138605]

Wahlsten D; Metten P; Crabbe JC. 2003. Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum. Brain Res 971(1):47-54. [PubMed: 12691836]  [MGI Ref ID J:83159]

Whitehead GS; Walker JK; Berman KG; Foster WM; Schwartz DA. 2003. Allergen-induced airway disease is mouse strain dependent. Am J Physiol Lung Cell Mol Physiol 285(1):L32-42. [PubMed: 12626335]  [MGI Ref ID J:84265]

Disc1^del related

Clapcote SJ; Roder JC. 2006. Deletion polymorphism of disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function. Genetics 173(4):2407-10. [PubMed: 16751659]  [MGI Ref ID J:111837]

Clapcote SJ; Roder JC. 2007. Inbred mouse strains 101/RI, BTBR T tf/J and LP/J have a deletion in Disc1 MGI Direct Data Submission :.  [MGI Ref ID J:118317]

Koike H; Arguello PA; Kvajo M; Karayiorgou M; Gogos JA. 2006. Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc Natl Acad Sci U S A 103(10):3693-7. [PubMed: 16484369]  [MGI Ref ID J:107244]

T⁺ related

Abe K; Yamamura K; Suzuki M. 2000. Molecular and embryological characterization of a new transgene-induced null allele of mouse Brachyury locus. Mamm Genome 11(3):238-40. [PubMed: 10723731]  [MGI Ref ID J:60706]

Bilinski P; Schimenti J; Gossler A. 1997. A new spontaneous deletion on chromosome 17 including brachyury. Mamm Genome 8(12):932-3. [PubMed: 9383288]  [MGI Ref ID J:44446]

Bogani D; Siggers P; Brixey R; Warr N; Beddow S; Edwards J; Williams D; Wilhelm D; Koopman P; Flavell RA; Chi H; Ostrer H; Wells S; Cheeseman M; Greenfield A. 2009. Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. PLoS Biol 7(9):e1000196. [PubMed: 19753101]  [MGI Ref ID J:153050]

Bogani D; Warr N; Elms P; Davies J; Tymowska-Lalanne Z; Goldsworthy M; Cox RD; Keays DA; Flint J; Wilson V; Nolan P; Arkell R. 2004. New semidominant mutations that affect mouse development. Genesis 40(2):109. [PubMed: 15384171]  [MGI Ref ID J:93195]

Chao HH; Mentzer SE; Schimenti JC; You Y. 2003. Overlapping deletions define novel embryonic lethal loci in the mouse t complex. Genesis 35(2):133-42. [PubMed: 12533796]  [MGI Ref ID J:81651]

Harris BS; Ward-Bailey PF. 2001. Identification and Mapping of the brachyury-like 2 mouse mutant MGI Direct Data Submission :.  [MGI Ref ID J:72463]

Harris BS; Ward-Bailey PF. 2001. Identification and Mapping of the brachyury-like 3 mouse mutant MGI Direct Data Submission :.  [MGI Ref ID J:72464]

Harrison SM; Houzelstein D; Dunwoodie SL; Beddington RS. 2000. Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with brachyury Dev Biol 227(2):358-72. [PubMed: 11071760]  [MGI Ref ID J:65743]

Johnson DR. 1974. Further observations on the haipin-tail (Thp) mutation in the mouse. Genet Res 24(2):207-13. [PubMed: 4452482]  [MGI Ref ID J:5522]

Johnson DR. 1974. Hairpin-tail: a case of post-reductional gene action in the mouse egg. Genetics 76(4):795-805. [PubMed: 4838760]  [MGI Ref ID J:31524]

Katoh H. 1989. Semidominant short tail (T<Jic>) Mouse News Lett 84:94-95.  [MGI Ref ID J:14257]

Lyon MF. 1959. A new dominant T-allele in the house mouse. J Hered 50:140-142.  [MGI Ref ID J:13072]

Lyon MF; Schimenti JC; Evans EP. 2000. Narrowing the critical regions for mouse t complex transmission ratio distortion factors by use of deletions Genetics 155(2):793-801. [PubMed: 10835400]  [MGI Ref ID J:62655]

Mouse Genome Informatics (MGI). 2006. Information obtained from The RIKEN BioResource Center :.  [MGI Ref ID J:104881]

Moutier R. 1973. t Mouse News Lett 49:42.  [MGI Ref ID J:15078]

Nolan PM; Peters J; Strivens M; Rogers D; Hagan J; Spurr N; Gray IC; Vizor L; Brooker D; Whitehill E; Washbourne R; Hough T; Greenaway S; Hewitt M; Liu X; McCormack S; Pickford K; Selley R; Wells C; Tymowska-Lalanne Z; Roby P; Glenister P; Thornton C; Thaung C; Stevenson JA; Arkell R; Mburu P; Hardisty R; Kiernan A; Erven A; Steel KP; Voegeling S; Guenet JL; Nickols C; Sadri R; Nasse M; Isaacs A; Davies K; Browne M; Fisher EM; Martin J; Rastan S; Brown SD; Hunter J. 2000. A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet 25(4):440-3. [PubMed: 10932191]  [MGI Ref ID J:63816]

Searle AG. 1966. Curtailed, a new dominant T-allele in the house mouse. Genet Res 7(1):86-95. [PubMed: 5906493]  [MGI Ref ID J:5003]

Searle AG. 1960. T<c> - curtailed Mouse News Lett 22:29.  [MGI Ref ID J:64262]

Shedlovsky A; King TR; Dove WF. 1988. Saturation germ line mutagenesis of the murine t region including a lethal allele at the quaking locus. Proc Natl Acad Sci U S A 85(1):180-4. [PubMed: 3422415]  [MGI Ref ID J:9032]

Stott D; Kispert A; Herrmann BG. 1993. Rescue of the tail defect of Brachyury mice. Genes Dev 7(2):197-203. [PubMed: 8436292]  [MGI Ref ID J:3956]

Wutz A; Theussl HC; Dausman J; Jaenisch R; Barlow DP; Wagner EF. 2001. Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice. Development 128(10):1881-7. [PubMed: 11311167]  [MGI Ref ID J:68721]

tf related

Crabbe JC; Cotnam CJ; Cameron AJ; Schlumbohm JP; Rhodes JS; Metten P; Wahlsten D. 2003. Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests. Genes Brain Behav 2(4):201-13. [PubMed: 12953786]  [MGI Ref ID J:104878]

Kusek GK; Wahlsten D; Herron BJ; Bolivar VJ; Flaherty L. 2007. Localization of two new X-linked quantitative trait loci controlling corpus callosum size in the mouse. Genes Brain Behav 6(4):359-63. [PubMed: 16899052]  [MGI Ref ID J:137289]

Lyon MF. 1956. Hereditary hair loss in the tufted mutant of the house mouse J Hered 47:101-3.  [MGI Ref ID J:273]

MacPherson P; McGaffigan R; Wahlsten D; Nguyen PV. 2008. Impaired fear memory, altered object memory and modified hippocampal synaptic plasticity in split-brain mice. Brain Res 1210:179-88. [PubMed: 18417102]  [MGI Ref ID J:136821]

Silver LM; Cisek L; Jackson C; Lukralle D. 1985. A new spontaneous mutation at the tufted locus within a mouse t haplotype. Genet Res 45(1):107-12. [PubMed: 3996911]  [MGI Ref ID J:7861]

Yang M; Clarke AM; Crawley JN. 2009. Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability. Eur J Neurosci 29(8):1663-77. [PubMed: 19419429]  [MGI Ref ID J:148483]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX8

Colony Maintenance

Mating System	Sibling x Sibling         (Female x Male)   01-MAR-06
Diet Information	LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply	Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.
Supply Notes	JAX® mES Cells: Each vial contains 3 million cells. Visit our JAX® Cells, Tissues and Products website for more information. Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. Genomic DNA is available for this strain from the Mouse DNA Resource.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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