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Strain Name:

BTBR T+ tf/J

Stock Number:

002282

Availability:

Level 4

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General Terms and Conditions

Genes & Alleles   Disc1;   Disc1del;   T;   T+;   tf;

Product Information

Strain Details

Type Inbred Strain
Additional information on Inbred Strains.
Type JAX® GEMM® Strain - Mutant Strain
Additional information on JAX® GEMM® Strains.
Mating SystemSibling x Sibling         (Female x Male)
Specieslaboratory mouse
H2 Haplotypeb
GenerationF?+34 (11-JAN-08)

Appearance
black and tan, tufted
Related Genotype: at/at T+/T+ tf/tf

Mammalian Phenotype Terms assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

tf/tf

        Background Not Specified
  • skin/coat/nails phenotype
  • abnormal coat/ hair morphology (J:273)
    • detectable about 4 weeks of age
    • alternating waves of hair loss and growth are repeated throughout the life of the mouse
    • abnormal hair growth (J:273)
      • abnormal hair cycle (J:273)
        • a wave of hair loss begins ventrally under the jaw and spreads posteriorly
        • a few days after ventral hair loss a similar dorsal wave of hair loss begins at the face, not including whiskers
        • a normal wave of hair growth follows the initial loss pattern
      • sparse hair (J:273)
        • waves of hair loss and growth create a sparse hair appearance anterior to posterior, ventral and dorsal

Gene & Allele Details

Allele Symbol T+
Allele Name wild type
Gene Symbol and Name T, brachyury
Chromosome 17
Gene Common Name(s) Bra; Low; Lr; MGC104817; T1; TFT; Tl2; Tl3; brachyury-like 2; brachyury-like 3; cou; coupe; low ratio; me75;
 
Allele Symbol tf
Allele Name tufted
 
Allele Symbol Disc1del
Allele Name deletion
Common Name(s) Disc1129S6;
Strain of Originvarious
Gene Symbol and Name Disc1, disrupted in schizophrenia 1
Chromosome 8
Gene Common Name(s) KIAA0457; SCZD9;
General Note This deletion appears in multiple strains of the 129 superfamily. See J:111837 for details. This deletion has further been identified in the following strains:101/RI, BTBR T+ Tf/J and LP/J J:118317
Molecular Note A 25 bp deletion of the locus causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon at exon 7. [J:107244]

Colony Maintenance

Diet Information LabDiet® 5K52/5K67

Related Strains

Strains carrying   Disc1del allele
001137   129P1/ReJ
000690   129P3/J
001198   129P4/RrRkJ
002448   129S1/SvImJ
002064   129T2/SvEms
002065   129T2/SvEmsJ
000691   129X1/SvJ
000676   LP/J
View Strains carrying   Disc1del     (8 strains)

Strains carrying   tf allele
003879   B10;TFLe-a/a T tf/+ tf/J
001518   B6 x STOCK T tf/th45 tf/J
001874   STOCK tw82 tf/J
000588   TF/GnLe-T(1;17)190Ca +/+ tf/J
View Strains carrying   tf     (4 strains)

Strains carrying other alleles of T
003879   B10;TFLe-a/a T tf/+ tf/J
000405   B10ScSn.Cg-T/J
004591   B6 x B6Ei.Cg-TWis/EiJ
000953   B6 x BALB/cBy-T4J/J
001518   B6 x STOCK T tf/th45 tf/J
000567   B6.Cg-T2J +/+ Qkqk/J
001015   B6.Cg-T4Or/J
001054   B6.Cg-TOrl/EiJ
000350   B6By.Cg-KitW-v MitfMi-wh T/J
001053   C3Sn.AK-Thp/EiJ
000545   C57BL/6J-T2J/J
001199   C57BL/6J-T5J/J
001961   C57BL/6JEi x STOCK T T(16;17)43H/+ T(16;17)43H/Ei
001814   STOCK Tc/J
View Strains carrying other alleles of T     (14 strains)

Phenotypic Data

Mouse Phenome Database

Additional Web Information

Genetic Quality Control Annual Report
JAX Notes, Winter 2006; 504. JAX® Mice: the Gold Standard Just Got Better.

Animal Health Reports

Room Number           AX8

Research Applications

This mouse can be used to support research in many areas including:

Dermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects

tf related

Dermatology Research
Skin and Hair Texture Defects

References

Additional References

Price and Supply Information

Strain Name: BTBR T+ tf/J
Stock Number: 002282

Price Details

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Supply Details

Standard SupplyLevel 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one-three months.
Supply Notes Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
Strains that must be genotyped are not available until five to seven weeks of age.
Genomic DNA is available for this strain from the Mouse DNA Resource.
LicensingSee General Terms and Conditions below  

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering and Purchasing Information

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Contact Information
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