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Genes & Alleles

Disc1;   Disc1del;   T;   T+;   tf;

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Product Information

Strain Details

Type Inbred Strain Additional information on Inbred Strains. Type JAX® GEMM® Strain - Mutant Strain Additional information on JAX® GEMM® Strains. Mating System Sibling x Sibling         (Female x Male) Species laboratory mouse H2 Haplotype b Generation F?+34 (11-JAN-08)

Appearance
black and tan, tufted
Related Genotype: a^t/a^t T⁺/T⁺ tf/tf

Mammalian Phenotype Terms assigned by genotype The following phenotype information may relate to a genetic background differing from this JAX® Mice strain. tf/tf         Background Not Specified skin/coat/nails phenotype abnormal coat/ hair morphology (MGI Ref ID J:273) detectable about 4 weeks of age alternating waves of hair loss and growth are repeated throughout the life of the mouse abnormal hair growth (MGI Ref ID J:273) abnormal hair cycle (MGI Ref ID J:273) a wave of hair loss begins ventrally under the jaw and spreads posteriorly a few days after ventral hair loss a similar dorsal wave of hair loss begins at the face, not including whiskers a normal wave of hair growth follows the initial loss pattern sparse hair (MGI Ref ID J:273) waves of hair loss and growth create a sparse hair appearance anterior to posterior, ventral and dorsal

Gene & Allele Details

Allele Symbol		T+
Allele Name		wild type
Gene Symbol and Name		T, brachyury
Chromosome		17
Gene Common Name(s)		Bra; Low; Lr; MGC104817; T1; TFT; Tl2; Tl3; brachyury-like 2; brachyury-like 3; cou; coupe; low ratio; me75;
Allele Symbol		tf
Allele Name		tufted
Allele Symbol		Disc1del
Allele Name		deletion
Common Name(s)		Disc1129S6;
Strain of Origin		various
Gene Symbol and Name		Disc1, disrupted in schizophrenia 1
Chromosome		8
Gene Common Name(s)		C1orf136; FLJ13381; FLJ21640; FLJ25311; FLJ41105; KIAA0457; SCZD9;
General Note		This deletion appears in multiple strains of the 129 superfamily. See J:111837 for details. This deletion has further been identified in the following strains:101/RI, BTBR T+ Tf/J and LP/J J:118317
Molecular Note		A 25 bp deletion of the locus causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon at exon 7. [MGI Ref ID J:107244]

Colony Maintenance

Diet Information	LabDiet® 5K52/5K67

Related Strains

Strains carrying   Disc1^del allele

001137	129P1/ReJ
000690	129P3/J
001198	129P4/RrRkJ
002448	129S1/SvImJ
002064	129T2/SvEms
002065	129T2/SvEmsJ
000691	129X1/SvJ
000676	LP/J

View Strains carrying   Disc1^del     (8 strains)

Strains carrying   tf allele

003879	B10;TFLe-a/a T tf/+ tf/J
001518	B6 x STOCK T tf/th45 tf/J
001874	STOCK tw82 tf/J
000588	TF/GnLe-T(1;17)190Ca +/+ tf/J

View Strains carrying   tf     (4 strains)

Strains carrying other alleles of T

003879	B10;TFLe-a/a T tf/+ tf/J
000405	B10ScSn.Cg-T/J
004591	B6 x B6Ei.Cg-TWis/EiJ
000953	B6 x BALB/cBy-T4J/J
001518	B6 x STOCK T tf/th45 tf/J
000567	B6.Cg-T2J +/+ Qkqk/J
001015	B6.Cg-T4Or/J
001054	B6.Cg-TOrl/EiJ
000350	B6By.Cg-KitW-v MitfMi-wh T/J
001053	C3Sn.AK-Thp/EiJ
000545	C57BL/6J-T2J/J
001199	C57BL/6J-T5J/J
001961	C57BL/6JEi x STOCK T T(16;17)43H/+ T(16;17)43H/Ei
001814	STOCK Tc/J

View Strains carrying other alleles of T     (14 strains)

Phenotypic Data

Mouse Phenome Database

Additional Web Information

Genetic Quality Control Annual Report
JAX^® NOTES, Winter 2006; 504. JAX^® Mice: the Gold Standard Just Got Better.

Animal Health Reports

Room Number           AX8

Research Applications

This mouse can be used to support research in many areas including:

Dermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects

tf related

Dermatology Research
Skin and Hair Texture Defects

References

Additional References

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Price and Supply Information

Strain Name:	BTBR T+ tf/J
Stock Number:	002282

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:

• USA, Canada and Mexico
• International

*Pricing for Shipping Destination selected:

        International

Price(s) in US dollars ($)		Genotype(s) Provided
3-5 weeks	$66.90		Female
6 weeks	$69.40		Female
7 weeks	$71.90		Female
8 weeks	$74.40		Female
9 weeks	$76.90		Female
10 weeks	$79.40		Female
3-5 weeks	$66.90		Male
6 weeks	$69.40		Male
7 weeks	$71.90		Male
8 weeks	$74.40		Male
9 weeks	$76.90		Male
10 weeks	$79.40		Male

Supply Details

Standard Supply	Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.
Supply Notes	Histology and Tissue Collection Services are available for all JAX® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-207-288-5845. Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. Genomic DNA is available for this strain from the Mouse DNA Resource.
Licensing	See General Terms and Conditions below

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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