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Strain Name:

B6.Cg-KitW-19H/EiJ

Stock Number:

002283

Availability:

Repository-Cryopreserved

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General Terms and Conditions

Former Name      C57BL/6JEi-KitW-19H    (Changed: 12-MAR-08 )
Genes & Alleles   Kit;   KitW-19H;

Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic
Additional information on JAX® GEMM® Strains.
Type Deletion
Additional information on Mice with Chromosomal Aberrations.
Type JAX® GEMM® Strain - Mutant Strain
Type JAX® GEMM® Strain - Radiation Induced Mutation
Specieslaboratory mouse

Strain Description
This deletion is a dominant mutation causing white spotting on the feet, tail, belly, and occasionally elsewhere. Homozygosity is embryonic lethal. On the C57BL/6 background approximately 60% of heterozygous females have a closed vagina. The ovaries from these heterozygotes are normal and fine for transplantation. On the C57BL/6 background in the presence of the YAKR/J Chromosome (available from Stock No. 007250), KitW-19H heterozygosity results in sex reversed XY females.

Mammalian Phenotype Terms assigned by genotype

KitW-19H/Kit+

        B6.Cg-KitW-19H/EiJ
  • reproductive system phenotype
  • *normal* reproductive system phenotype (MGI Ref ID J:133405)
    • ovaries function and transplant fine
    • constricted vaginal opening (MGI Ref ID J:133405)
      • approximately 60% of females have clsoed vaginas

Gene & Allele Details

Allele Symbol KitW-19H
Allele Name dominant spotting 19 Harwell
Strain of Origin(C3H/HeH x 101/H)F1
Gene Symbol and Name Kit, kit oncogene
Chromosome 5
Gene Common Name(s) Bs; C-Kit; CD117; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; PBT; SCFR; SCO1; SCO5; SOW3; Ssm; Steel Factor Receptor; Tr-kit; W; belly-spot; dominant spotting; gsf spotted coat 1; gsf spotted coat 5; phenotype like Sl or W 3; spotted sterile male;
Molecular Note This allele comprises a deletion extending, minimally, from D5Mit58 to D5Mit112/D5Mit306, a genetic distance of approximately 2.8 cM. [MGI Ref ID J:19442] [MGI Ref ID J:29686] [MGI Ref ID J:41383] [MGI Ref ID J:9505]

Related Strains

View Strains carrying other alleles of Kit     (36 strains)

Additional Web Information

Congenic Nomenclature

Research Applications

This mouse can be used to support research in many areas including:

Developmental Biology Research
Internal/Organ Defects (gonads)

Reproductive Biology Research

Research Tools
Reproductive Biology Research

KitW-19H related

Dermatology Research
Color and White Spotting Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads

References

Selected Reference(s)

Lyon MF; Glenister PH; Loutit JF; Evans EP; Peters J. 1984. A presumed deletion covering the W and Ph loci of the mouse. Genet Res 44(2):161-8. [PubMed: 6510711]  [MGI Ref ID J:7681]

Washburn LL. 2008. Report of effects of C57BL/6 background on phenotype of W<19H> heterezygotes Personal Communication, The Jackson Laboratory :.  [MGI Ref ID J:133405]

Additional References

Price and Supply Information

Strain Name: B6.Cg-KitW-19H/EiJ
Stock Number: 002283

Price Details

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Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.

LicensingSee General Terms and Conditions below  

General Terms and Conditions

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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