Strain Name:

B6.129S7-Icam1tm1Bay Selptm1Bay/J

Stock Number:

002285

Availability:

Repository-Cryopreserved

Use Restrictions Apply, see Terms of Use

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered Mutant Mice.
Specieslaboratory mouse
Background Strain C57BL/6
GenerationN5F19p (08-JAN-04)
 
Donating Investigator Arthur Beaudet,   Baylor College of Medicine

Appearance
black
Related Genotype: a/a

Description
Mice homozygous for both the Icam1tm1Bay and Selptm1Bay targeted mutations are viable and fertile with no obvious phenotypic abnormalities. Homozygous mice have an increased number of neutrophils in the blood and a complete loss of neutrophil emmigration into the peritoneum in response to Streptococcus pneumoniae-induced peritonitis. Neutrophil emmigration into the alveolar spaces in response to S. pneumoniae-induced pneumonia is normal. In addition, circulating lymphocyte and monocyte levels are increased.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Icam1tm1Bay allele
002127   B6.129S7-Icam1tm1Bay/J
View Strains carrying   Icam1tm1Bay     (1 strain)

Strains carrying   Selptm1Bay allele
002289   B6.129S7-Selptm1Bay/J
View Strains carrying   Selptm1Bay     (1 strain)

Strains carrying other alleles of Icam1
002867   B6.129S4-Icam1tm1Jcgr/J
006351   NOD.129S4(B6)-Icam1tm1Jcgr/J
005983   NOD.129S4(B6)-Icam1tm1Jcgr/SmtnJ
View Strains carrying other alleles of Icam1     (3 strains)

View Strains carrying other alleles of Selp     (7 strains)

Additional Web Information

Congenic Nomenclature

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Icam1tm1Bay/Icam1tm1Bay Selptm1Bay/Selptm1Bay

        either: B6.129S7-Selptm1Bay Icam1tm1Bay or (involves: 129S7/SvEvBrd * C57BL/6)
  • immune system phenotype
  • abnormal leukocyte rolling (MGI Ref ID J:31374)
    • double mutants show no spontaneous rolling leukocyte activity
    • treatment with Tnfa induces leukocyte rolling although leukocytes show no spontaneous rolling activity; rolling flux fraction is ~22%, compared to ~36% in Icam1-deficient single mutants

Icam1tm1Bay/Icam1tm1Bay Selptm1Bay/Selptm1Bay

        B6.129S7-Icam1tm1Bay Selptm1Bay/J
  • nervous system phenotype
  • *normal* nervous system phenotype (MGI Ref ID J:119906)
    • no significant differences are detected in motor function (assessed at 1-5 days after CCI) or cognitive function (assessed at 14-20 days after injury) between mutants and wild-type mice
    • no significant differences are seen in contusion volume of the injured hemisphere or in volume of uninjured or injured hemisphere between wild-type and mutants 21 days after CCI
  • immune system phenotype
  • *normal* immune system phenotype (MGI Ref ID J:119906)
    • no difference in neutrophil accumulation at injury site at 24 hours after CCI is detected between mutant and wild-type mice
  • homeostasis/metabolism phenotype
  • edema (MGI Ref ID J:119906)
    • brain edema at 24 hours after controlled cortical impact (CCI) is decreased in mutants compared to controls; brain water content ratio of injured and uninjured hemispheres) is lower (1.90) than in controls (3.16)

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Icam1tm1Bay/Icam1tm1Bay Selptm1Bay/Selptm1Bay

        involves: 129S7/SvEvBrd * C57BL/6J
  • immune system phenotype
  • abnormal leukocyte migration/homing (MGI Ref ID J:24239)
    • Streptococcus pneumoniae induced peritonitis eliminated neutrophil emigration into peritoneum
    • Streptococcus pneumoniae induced pneumonia did not reduce neutrophil recruitment or edema formation in the alveolar space
  • increased neutrophil cell number (MGI Ref ID J:24239)
    • 4-5 fold increase in numbers of circulating neutrophils
  • hematopoietic system phenotype
  • increased neutrophil cell number (MGI Ref ID J:24239)
    • 4-5 fold increase in numbers of circulating neutrophils
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Icam1tm1Bay related

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation

Selptm1Bay related
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Inflammation

Genes & Alleles

Gene & Allele Information

Allele Symbol Icam1tm1Bay
Allele Name targeted mutation 1, Baylor College of Medicine
Allele Type Targeted (knock-out)
Common Name(s) CD54-; ICAM-1-;
Mutation Made By Arthur Beaudet,   Baylor College of Medicine
Strain of Origin129S7/SvEvBrd-Hprt1<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt1<+>
Gene Symbol and Name Icam1, intercellular adhesion molecule 1
Chromosome 9
Gene Common Name(s) BB2; CD54; ICAM; Icam-1; Ly-47; MALA-2; MGC:6195; P3.58; lymphocyte antigen 47;
Molecular Note A neomycin resistance cassette was inserted into exon 5 of the gene. Subsequent analysis reported by King, et. al. (J:25530) revealed the presence of alternatively spliced transcripts in both wild-type and homozygous mutant mice. Protein expression was detected in mutant mice in medullary stromal cells of the thymus, as well as in the lung and spleen. Variable splicing of exons 2 through 6, encoding extracellular Ig domains, results in the production of 3 isoforms (2-6, 3-6, 4-6, where the numbers refer to spliced exons) in mutant mice. In addition to the 3 found in mutant mice, 2 other alternative splice forms including exon 5 were identified in wild-type mice. The reading frame and exons 1 and 7, encoding the signal sequence and both the transmembrane and cytosolic domains, are left intact in each isoform. [MGI Ref ID J:14565] [MGI Ref ID J:25530]
 
Allele Symbol Selptm1Bay
Allele Name targeted mutation 1, Baylor College of Medicine
Allele Type Targeted (knock-out)
Common Name(s) CD62ELP-; CD62P-; P-; P-selectin-;
Mutation Made By Arthur Beaudet,   Baylor College of Medicine
Strain of Origin129S7/SvEvBrd-Hprt1
ES Cell Line NameAB2.1
ES Cell Line Strain129S7/SvEvBrd-Hprt1
Gene Symbol and Name Selp, selectin, platelet
Chromosome 1
Gene Common Name(s) CD62; CD62P; FLJ45155; GMP140; GRMP; Grmp; LECAM3; MGC124632; P-selectin; PADGEM; PSEL; PSELECT; granulocyte membrane protein;
Molecular Note A neomycin resistance gene was inserted in the reverse orientation to delete a 4.5kb region containing exons 3 through 5. RT-PCR analysis of lung RNA isolated from homozygous mutant mice showed a transcript 682 base pairs shorter than normal. Immunohistochemical staining showed a lack of encoded protein on both endothelium and platelets. [MGI Ref ID J:24239]

Genotyping

Genotyping Information

Genotyping Protocols

Icam1tm1Bay, STD PCR, vers. 1
Selptm1Bay, STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Bullard DC; Qin L; Lorenzo I; Quinlin WM; Doyle NA; Bosse R; Vestweber D; Doerschuk CM; Beaudet AL. 1995. P-selectin/ICAM-1 double mutant mice: acute emigration of neutrophils into the peritoneum is completely absent but is normal into pulmonary alveoli [see comments] J Clin Invest 95(4):1782-8. [PubMed: 7535798]  [MGI Ref ID J:24239]

Additional References

Sligh JE Jr; Ballantyne CM; Rich SS; Hawkins HK; Smith CW; Bradley A; Beaudet AL. 1993. Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc Natl Acad Sci U S A 90(18):8529-33. [PubMed: 8104338]  [MGI Ref ID J:14565]

Icam1tm1Bay related

Aoudjit F; Potworowski EF; Springer TA; St-Pierre Y. 1998. Protection from lymphoma cell metastasis in ICAM-1 mutant mice: a posthoming event. J Immunol 161(5):2333-8. [PubMed: 9725228]  [MGI Ref ID J:49717]

Avellino AM; Dailey AT; Harlan JM; Sharar SR; Winn RK; McNutt LD; Kliot M. 2004. Blocking of up-regulated ICAM-1 does not prevent macrophage infiltration during Wallerian degeneration of peripheral nerve. Exp Neurol 187(2):430-44. [PubMed: 15144869]  [MGI Ref ID J:90583]

Baker PJ; DuFour L; Dixon M; Roopenian DC. 2000. Adhesion molecule deficiencies increase Porphyromonas gingivalis-induced alveolar bone loss in mice. Infect Immun 68(6):3103-7. [PubMed: 10816450]  [MGI Ref ID J:62266]

Bendjelloul F; Maly P; Mandys V; Jirkovska M; Prokesova L; Tuckova L; Tlaskalova-Hogenova H. 2000. Intercellular adhesion molecule-1 (ICAM-1) deficiency protects mice against severe forms of experimentally induced colitis. Clin Exp Immunol 119(1):57-63. [PubMed: 10606964]  [MGI Ref ID J:110249]

Berberich S; Dahne S; Schippers A; Peters T; Muller W; Kremmer E; Forster R; Pabst O. 2008. Differential molecular and anatomical basis for B cell migration into the peritoneal cavity and omental milky spots. J Immunol 180(4):2196-203. [PubMed: 18250426]  [MGI Ref ID J:132002]

Bourdillon MC; Poston RN; Covacho C; Chignier E; Bricca G; McGregor JL. 2000. ICAM-1 deficiency reduces atherosclerotic lesions in double-knockout mice (ApoE(-/-)/ICAM-1(-/-)) fed a fat or a chow diet. Arterioscler Thromb Vasc Biol 20(12):2630-5. [PubMed: 11116064]  [MGI Ref ID J:103384]

Briaud SA; Ding ZM; Michael LH; Entman ML; Daniel S; Ballantyne CM. 2001. Leukocyte trafficking and myocardial reperfusion injury in ICAM-1/P-selectin-knockout mice. Am J Physiol Heart Circ Physiol 280(1):H60-7. [PubMed: 11123218]  [MGI Ref ID J:68056]

Broide DH; Humber D; Sullivan S; Sriramarao P. 1998. Inhibition of eosinophil rolling and recruitment in P-selectin- and intracellular adhesion molecule-1-deficient mice [published erratum appears in Blood 1998 Jul 1;92(1):343] Blood 91(8):2847-56. [PubMed: 9531595]  [MGI Ref ID J:47461]

Broide DH; Sullivan S; Gifford T; Sriramarao P. 1998. Inhibition of pulmonary eosinophilia in P-selectin- and ICAM-1-deficient mice. Am J Respir Cell Mol Biol 18(2):218-25. [PubMed: 9476909]  [MGI Ref ID J:114264]

Bullard DC; Hurley LA; Lorenzo I; Sly LM; Beaudet AL; Staite ND. 1996. Reduced susceptibility to collagen-induced arthritis in mice deficient in intercellular adhesion molecule-1. J Immunol 157(7):3153-8. [PubMed: 8816427]  [MGI Ref ID J:36071]

Bullard DC; King PD; Hicks MJ; Dupont B; Beaudet AL; Elkon KB. 1997. Intercellular adhesion molecule-1 deficiency protects MRL/MpJ-Fas(lpr) mice from early lethality. J Immunol 159(4):2058-67. [PubMed: 9257874]  [MGI Ref ID J:42669]

Calingasan NY; Huang PL; Chun HS; Fabian A; Gibson GE. 2000. Vascular factors are critical in selective neuronal loss in an animal model of impaired oxidative metabolism. J Neuropathol Exp Neurol 59(3):207-17. [PubMed: 10744059]  [MGI Ref ID J:62409]

Carrithers MD; Visintin I; Viret C; Janeway CS Jr. 2002. Role of genetic background in P selectin-dependent immune surveillance of the central nervous system. J Neuroimmunol 129(1-2):51-7. [PubMed: 12161020]  [MGI Ref ID J:102957]

Collins RG; Velji R; Guevara NV; Hicks MJ; Chan L; Beaudet AL. 2000. P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice. J Exp Med 191(1):189-94. [PubMed: 10620617]  [MGI Ref ID J:59249]

Dautigny N; Le Campion A; Lucas B. 1999. Timing and casting for actors of thymic negative selection. J Immunol 162(3):1294-302. [PubMed: 9973382]  [MGI Ref ID J:124433]

Davis SL; Hawkins EP; Mason EO Jr; Smith CW; Kaplan SL. 1996. Host defenses against disseminated candidiasis are impaired in intercellular adhesion molecule 1-deficient mice. J Infect Dis 174(2):435-9. [PubMed: 8699084]  [MGI Ref ID J:34394]

Doerschuk CM; Quinlan WM; Doyle NA; Bullard DC; Vestweber D; Jones ML; Takei F; Ward PA; Beaudet AL. 1996. The role of P-selectin and ICAM-1 in acute lung injury as determined using blocking antibodies and mutant mice. J Immunol 157(10):4609-14. [PubMed: 8906840]  [MGI Ref ID J:37197]

Emoto M; Emoto Y; Brinkmann V; Miyamoto M; Yoshizawa I; Staber M; van Rooijen N; Hamann A; Kaufmann SH. 2003. Increased resistance of LFA-1-deficient mice to lipopolysaccharide-induced shock/liver injury in the presence of TNF-alpha and IL-12 is mediated by IL-10: a novel role for LFA-1 in the regulation of the proinflammatory and anti-inflammatory cytokine balance. J Immunol 171(2):584-93. [PubMed: 12847222]  [MGI Ref ID J:123460]

Emoto M; Mittrucker HW; Schmits R; Mak TW; Kaufmann SH. 1999. Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells. J Immunol 162(9):5094-8. [PubMed: 10227978]  [MGI Ref ID J:111009]

Eppihimer MJ; Russell J; Anderson DC; Wolitzky BA; Granger DN. 1997. Endothelial cell adhesion molecule expression in gene-targeted mice. Am J Physiol 273(4 Pt 2):H1903-8. [PubMed: 9362259]  [MGI Ref ID J:43907]

Fogler WE; Volker K; Watanabe M; Wigginton JM; Roessler P; Brunda MJ; Ortaldo JR; Wiltrout RH. 1998. Recruitment of hepatic NK cells by IL-12 is dependent on IFN-gamma and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas. J Immunol 161(11):6014-21. [PubMed: 9834083]  [MGI Ref ID J:115033]

Forbes E; Hulett M; Ahrens R; Wagner N; Smart V; Matthaei KI; Brandt EB; Dent LA; Rothenberg ME; Tang M; Foster PS; Hogan SP. 2006. ICAM-1-dependent pathways regulate colonic eosinophilic inflammation. J Leukoc Biol 80(2):330-41. [PubMed: 16731772]  [MGI Ref ID J:111227]

Furusho S; Myou S; Fujimura M; Kita T; Yasui M; Kasahara K; Nakao S; Takehara K; Sato S. 2006. Role of intercellular adhesion molecule-1 in a murine model of toluene diisocyanate-induced asthma. Clin Exp Allergy 36(10):1294-302. [PubMed: 17014439]  [MGI Ref ID J:135960]

Graciano AL; Bryant DD; White DJ; Horton J; Bowles NE; Giroir BP. 2001. Targeted disruption of ICAM-1, P-selectin genes improves cardiac function and survival in TNF-alpha transgenic mice. Am J Physiol Heart Circ Physiol 280(4):H1464-71. [PubMed: 11247755]  [MGI Ref ID J:108278]

Gregoire FM; Zhang Q; Smith SJ; Tong C; Ross D; Lopez H; West DB. 2002. Diet-induced obesity and hepatic gene expression alterations in C57BL/6J and ICAM-1-deficient mice. Am J Physiol Endocrinol Metab 282(3):E703-13. [PubMed: 11832376]  [MGI Ref ID J:75612]

Gurish MF; Tao H; Abonia JP; Arya A; Friend DS; Parker CM; Austen KF. 2001. Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing. J Exp Med 194(9):1243-52. [PubMed: 11696590]  [MGI Ref ID J:119138]

Hafezi-Moghadam A; Thomas KL; Prorock AJ; Huo Y; Ley K. 2001. L-selectin shedding regulates leukocyte recruitment. J Exp Med 193(7):863-72. [PubMed: 11283159]  [MGI Ref ID J:120579]

Hallahan DE; Virudachalam S. 1997. Intercellular adhesion molecule 1 knockout abrogates radiation induced pulmonary inflammation. Proc Natl Acad Sci U S A 94(12):6432-7. [PubMed: 9177235]  [MGI Ref ID J:111185]

Hamaguchi Y; Nishizawa Y; Yasui M; Hasegawa M; Kaburagi Y; Komura K; Nagaoka T; Saito E; Shimada Y; Takehara K; Kadono T; Steeber DA; Tedder TF; Sato S. 2002. Intercellular adhesion molecule-1 and L-selectin regulate bleomycin-induced lung fibrosis. Am J Pathol 161(5):1607-18. [PubMed: 12414509]  [MGI Ref ID J:79905]

Hancock WW; Tsai TL; Madaio MP; Gasser DL. 2003. Cutting Edge: Multiple autoimmune pathways in kd/kd mice. J Immunol 171(6):2778-81. [PubMed: 12960297]  [MGI Ref ID J:85380]

Hoefer IE; van Royen N; Rectenwald JE; Deindl E; Hua J; Jost M; Grundmann S; Voskuil M; Ozaki CK; Piek JJ; Buschmann IR. 2004. Arteriogenesis proceeds via ICAM-1/Mac-1- mediated mechanisms. Circ Res 94(9):1179-85. [PubMed: 15059933]  [MGI Ref ID J:98899]

Horie Y; Wolf R; Anderson DC; Granger DN. 1997. Hepatic leukostasis and hypoxic stress in adhesion molecule-deficient mice after gut ischemia/reperfusion. J Clin Invest 99(4):781-8. [PubMed: 9045883]  [MGI Ref ID J:39161]

Huleatt JW; Lefrancois L. 1996. Beta2 integrins and ICAM-1 are involved in establishment of the intestinal mucosal T cell compartment. Immunity 5(3):263-73. [PubMed: 8808681]  [MGI Ref ID J:35355]

Igietseme JU; Ananaba GA; Bolier J; Bowers S; Moore T; Belay T; Lyn D; Black CM. 1999. The intercellular adhesion molecule type-1 is required for rapid activation of T helper type 1 lymphocytes that control early acute phase of genital chlamydial infection in mice. Immunology 98(4):510-9. [PubMed: 10594682]  [MGI Ref ID J:59099]

Isaksson J; Farooque M; Olsson Y. 2000. Spinal cord injury in ICAM-1-deficient mice: assessment of functional and histopathological outcome J Neurotrauma 17(4):333-44. [PubMed: 10776916]  [MGI Ref ID J:62351]

John B; Crispe IN. 2004. Passive and active mechanisms trap activated CD8+ T cells in the liver. J Immunol 172(9):5222-9. [PubMed: 15100260]  [MGI Ref ID J:89684]

Jones SP; Trocha SD; Strange MB; Granger DN; Kevil CG; Bullard DC; Lefer DJ. 2000. Leukocyte and endothelial cell adhesion molecules in a chronic murine model of myocardial reperfusion injury Am J Physiol Heart Circ Physiol 279(5):H2196-201. [PubMed: 11045953]  [MGI Ref ID J:65658]

Joussen AM; Poulaki V; Le ML; Koizumi K; Esser C; Janicki H; Schraermeyer U; Kociok N; Fauser S; Kirchhof B; Kern TS; Adamis AP. 2004. A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J 18(12):1450-2. [PubMed: 15231732]  [MGI Ref ID J:118466]

Kaburagi Y; Hasegawa M; Nagaoka T; Shimada Y; Hamaguchi Y; Komura K; Saito E; Yanaba K; Takehara K; Kadono T; Steeber DA; Tedder TF; Sato S. 2002. The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression. J Immunol 168(6):2970-8. [PubMed: 11884469]  [MGI Ref ID J:112251]

Kadono T; Venturi GM; Steeber DA; Tedder TF. 2002. Leukocyte rolling velocities and migration are optimized by cooperative L-selectin and intercellular adhesion molecule-1 functions. J Immunol 169(8):4542-50. [PubMed: 12370391]  [MGI Ref ID J:79530]

Kamochi M; Kamochi F; Kim YB; Sawh S; Sanders JM; Sarembock I; Green S; Young JS; Ley K; Fu SM; Rose CE Jr. 1999. P-selectin and ICAM-1 mediate endotoxin-induced neutrophil recruitment and injury to the lung and liver. Am J Physiol 277(2 Pt 1):L310-9. [PubMed: 10444525]  [MGI Ref ID J:56844]

Kawasuji A; Hasegawa M; Horikawa M; Fujita T; Matsushita Y; Matsushita T; Fujimoto M; Steeber DA; Tedder TF; Takehara K; Sato S. 2006. L-selectin and intercellular adhesion molecule-1 regulate the development of Concanavalin A-induced liver injury. J Leukoc Biol 79(4):696-705. [PubMed: 16461740]  [MGI Ref ID J:107551]

Kevil CG; Bullard DC. 2001. In vitro culture and characterization of gene targeted mouse endothelium. Acta Physiol Scand 173(1):151-7. [PubMed: 11678738]  [MGI Ref ID J:125215]

Kevil CG; Orr AW; Langston W; Mickett K; Murphy-Ullrich J; Patel RP; Kucik DF; Bullard DC. 2004. Intercellular adhesion molecule-1 (ICAM-1) regulates endothelial cell motility through a nitric oxide-dependent pathway. J Biol Chem 279(18):19230-8. [PubMed: 14985356]  [MGI Ref ID J:124261]

Kevil CG; Patel RP; Bullard DC. 2001. Essential role of ICAM-1 in mediating monocyte adhesion to aortic endothelial cells. Am J Physiol Cell Physiol 281(5):C1442-7. [PubMed: 11600406]  [MGI Ref ID J:72559]

King PD; Sandberg ET; Selvakumar A; Fang P; Beaudet AL; Dupont B. 1995. Novel isoforms of murine intercellular adhesion molecule-1 generated by alternative RNA splicing. J Immunol 154(11):6080-6093. [PubMed: 7751650]  [MGI Ref ID J:25530]

Kitagawa K; Matsumoto M; Ohtsuki T; Kuwabara K; Mabuchi T; Yagita Y; Hori M; Yanagihara T. 1999. Deficiency of intercellular adhesion molecule 1 fails to mitigate selective neuronal death after transient global ischemia. Brain Res 847(2):166-74. [PubMed: 10575085]  [MGI Ref ID J:58597]

Kohm AP; Miller SD. 2003. Role of ICAM-1 and P-selectin expression in the development and effector function of CD4+CD25+regulatory T cells. J Autoimmun 21(3):261-71. [PubMed: 14599851]  [MGI Ref ID J:86435]

Komura K; Hasegawa M; Hamaguchi Y; Saito E; Kaburagi Y; Yanaba K; Kawara S; Takehara K; Seki M; Steeber DA; Tedder TF; Sato S. 2003. Ultraviolet light exposure suppresses contact hypersensitivity by abrogating endothelial intercellular adhesion molecule-1 up-regulation at the elicitation site. J Immunol 171(6):2855-62. [PubMed: 12960307]  [MGI Ref ID J:85377]

Kono H; Uesugi T; Froh M; Rusyn I; Bradford BU; Thurman RG. 2001. ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice. Am J Physiol Gastrointest Liver Physiol 280(6):G1289-95. [PubMed: 11352823]  [MGI Ref ID J:69880]

Kunkel EJ; Jung U; Bullard DC; Norman KE; Wolitzky BA; Vestweber D; Beaudet AL; Ley K. 1996. Absence of trauma-induced leukocyte rolling in mice deficient in both P-selectin and intercellular adhesion molecule 1. J Exp Med 183(1):57-65. [PubMed: 8551244]  [MGI Ref ID J:31374]

Lacha J; Bushell A; Smetana K; Rossmann P; Pribylova P; Wood K; Maly P. 2002. Intercellular cell adhesion molecule-1 and selectin ligands in acute cardiac allograft rejection: a study on gene-deficient mouse models. J Leukoc Biol 71(2):311-8. [PubMed: 11818453]  [MGI Ref ID J:74694]

Langston W; Chidlow JH Jr; Booth BA; Barlow SC; Lefer DJ; Patel RP; Kevil CG. 2007. Regulation of endothelial glutathione by ICAM-1 governs VEGF-A-mediated eNOS activity and angiogenesis. Free Radic Biol Med 42(5):720-729. [PubMed: 17291995]  [MGI Ref ID J:118196]

Lee SH; Prince JE; Rais M; Kheradmand F; Ballantyne CM; Weitz-Schmidt G; Smith CW; Corry DB. 2008. Developmental control of integrin expression regulates th2 effector homing. J Immunol 180(7):4656-67. [PubMed: 18354189]  [MGI Ref ID J:133389]

Ley K; Allietta M; Bullard DC; Morgan S. 1998. Importance of E-selectin for firm leukocyte adhesion in vivo. Circ Res 83(3):287-94. [PubMed: 9710121]  [MGI Ref ID J:110975]

Manka D; Collins RG; Ley K; Beaudet AL; Sarembock IJ. 2001. Absence of p-selectin, but not intercellular adhesion molecule-1, attenuates neointimal growth after arterial injury in apolipoprotein e-deficient mice. Circulation 103(7):1000-5. [PubMed: 11181476]  [MGI Ref ID J:103301]

Marvin MR; Southall JC; Trokhan S; DeRosa C; Chabot J. 1998. Liver metastases are enhanced in homozygous deletionally mutant ICAM-1 or LFA-1 mice. J Surg Res 80(2):143-8. [PubMed: 9878305]  [MGI Ref ID J:52466]

Massberg S; Enders G; Matos FC; Tomic LI; Leiderer R; Eisenmenger S; Messmer K; Krombach F. 1999. Fibrinogen deposition at the postischemic vessel wall promotes platelet adhesion during ischemia-reperfusion in vivo. Blood 94(11):3829-38. [PubMed: 10572098]  [MGI Ref ID J:58823]

McCafferty DM; Kanwar S; Granger DN; Kubes P. 2000. E/P-selectin-deficient mice: an optimal mutation for abrogating antigen but not tumor necrosis factor-alpha-induced immune responses Eur J Immunol 30(8):2362-71. [PubMed: 10940927]  [MGI Ref ID J:63951]

McCafferty DM; Smith CW; Granger DN; Kubes P. 1999. Intestinal inflammation in adhesion molecule-deficient mice: an assessment of P-selectin alone and in combination with ICAM-1 or E-selectin. J Leukoc Biol 66(1):67-74. [PubMed: 10410991]  [MGI Ref ID J:56590]

Metzler B; Mair J; Lercher A; Schaber C; Hintringer F; Pachinger O; Xu Q. 2001. Mouse model of myocardial remodelling after ischemia: role of intercellular adhesion molecule-1. Cardiovasc Res 49(2):399-407. [PubMed: 11164850]  [MGI Ref ID J:102573]

Mizgerd JP; Bullard DC; Hicks MJ; Beaudet AL; Doerschuk CM. 1999. Chronic inflammatory disease alters adhesion molecule requirements for acute neutrophil emigration in mouse skin. J Immunol 162(9):5444-8. [PubMed: 10228023]  [MGI Ref ID J:112286]

Nagaoka T; Kaburagi Y; Hamaguchi Y; Hasegawa M; Takehara K; Steeber DA; Tedder TF; Sato S. 2000. Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression. Am J Pathol 157(1):237-47. [PubMed: 10880393]  [MGI Ref ID J:63135]

Norman MU; James WG; Hickey MJ. 2008. Differential roles of ICAM-1 and VCAM-1 in leukocyte-endothelial cell interactions in skin and brain of MRL/faslpr mice. J Leukoc Biol 84(1):68-76. [PubMed: 18426970]  [MGI Ref ID J:137748]

O'Brien AD; Standiford TJ; Bucknell KA; Wilcoxen SE; Paine R 3rd. 1999. Role of alveolar epithelial cell intercellular adhesion molecule-1 in host defense against Klebsiella pneumoniae. Am J Physiol 276(6 Pt 1):L961-70. [PubMed: 10362721]  [MGI Ref ID J:55939]

Ohteki T; Maki C; Koyasu S; Mak TW; Ohashi PS. 1999. Cutting edge: LFA-1 is required for liver NK1.1+TCR alpha beta+ cell development: evidence that liver NK1.1+TCR alpha beta+ cells originate from multiple pathways. J Immunol 162(7):3753-6. [PubMed: 10201888]  [MGI Ref ID J:53578]

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Papayannopoulou T; Priestley GV; Nakamoto B; Zafiropoulos V; Scott LM. 2001. Molecular pathways in bone marrow homing: dominant role of alpha(4)beta(1) over beta(2)-integrins and selectins. Blood 98(8):2403-11. [PubMed: 11588037]  [MGI Ref ID J:115624]

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Pelletier SD; Hong DS; Hu Y; Liu Y; Li S. 2004. Lack of the adhesion molecules P-selectin and intercellular adhesion molecule-1 accelerate the development of BCR/ABL-induced chronic myeloid leukemia-like myeloproliferative disease in mice. Blood 104(7):2163-71. [PubMed: 15213099]  [MGI Ref ID J:93772]

Pierangeli SS; Espinola RG; Liu X; Harris EN. 2001. Thrombogenic effects of antiphospholipid antibodies are mediated by intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and P-selectin. Circ Res 88(2):245-50. [PubMed: 11157679]  [MGI Ref ID J:115602]

Piguet PF; Vesin C; Rochat A. 2001. Beta2 integrin modulates platelet caspase activation and life span in mice. Eur J Cell Biol 80(2):171-7. [PubMed: 11302522]  [MGI Ref ID J:102596]

Raisanen-Sokolowski A; Glysing-Jensen T; Russell ME. 1999. Donor and recipient contributions of ICAM-1 and P-selectin in parenchymal rejection and graft arteriosclerosis: insights from double knockout mice. J Heart Lung Transplant 18(8):735-43. [PubMed: 10512519]  [MGI Ref ID J:59743]

Sakurai E; Taguchi H; Anand A; Ambati BK; Gragoudas ES; Miller JW; Adamis AP; Ambati J. 2003. Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization. Invest Ophthalmol Vis Sci 44(6):2743-9. [PubMed: 12766082]  [MGI Ref ID J:119416]

Samoilova EB; Horton JL; Chen Y. 1998. Experimental autoimmune encephalomyelitis in intercellular adhesion molecule-1-deficient mice. Cell Immunol 190(1):83-9. [PubMed: 9826450]  [MGI Ref ID J:51770]

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Saunders BM; Frank AA; Orme IM. 1999. Granuloma formation is required to contain bacillus growth and delay mortality in mice chronically infected with Mycobacterium tuberculosis. Immunology 98(3):324-8. [PubMed: 10583589]  [MGI Ref ID J:58378]

Schneeberger EE; Vu Q; LeBlanc BW; Doerschuk CM. 2000. The accumulation of dendritic cells in the lung is impaired in CD18-/- but not in ICAM-1-/- mutant mice. J Immunol 164(5):2472-8. [PubMed: 10679084]  [MGI Ref ID J:60566]

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Shimada Y; Hasegawa M; Kaburagi Y; Hamaguchi Y; Komura K; Saito E; Takehara K; Steeber DA; Tedder TF; Sato S. 2003. L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity. J Immunol 170(8):4325-34. [PubMed: 12682269]  [MGI Ref ID J:125436]

Sligh JE Jr; Ballantyne CM; Rich SS; Hawkins HK; Smith CW; Bradley A; Beaudet AL. 1993. Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc Natl Acad Sci U S A 90(18):8529-33. [PubMed: 8104338]  [MGI Ref ID J:14565]

Steeber DA; Campbell MA; Basit A; Ley K; Tedder TF. 1998. Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expression. Proc Natl Acad Sci U S A 95(13):7562-7. [PubMed: 9636189]  [MGI Ref ID J:48271]

Steeber DA; Tang ML; Green NE; Zhang XQ; Sloane JE; Tedder TF. 1999. Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathways. J Immunol 163(4):2176-86. [PubMed: 10438959]  [MGI Ref ID J:57424]

Steinhoff U; Klemm U; Greiner M; Bordasch K; Kaufmann SH. 1998. Altered intestinal immune system but normal antibacterial resistance in the absence of P-selectin and ICAM-1. J Immunol 160(12):6112-20. [PubMed: 9637528]  [MGI Ref ID J:48760]

Sun G; Chang WL; Li J; Berney SM; Kimpel D; van der Heyde HC. 2003. Inhibition of platelet adherence to brain microvasculature protects against severe Plasmodium berghei malaria. Infect Immun 71(11):6553-61. [PubMed: 14573677]  [MGI Ref ID J:86276]

Tan TQ; Smith CW; Hawkins EP; Mason EO Jr; Kaplan SL. 1995. Hematogenous bacterial meningitis in an intercellular adhesion molecule-1-deficient infant mouse model. J Infect Dis 171(2):342-9. [PubMed: 7844370]  [MGI Ref ID J:22677]

Tu L; Poe JC; Kadono T; Venturi GM; Bullard DC; Tedder TF; Steeber DA. 2002. A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo. J Immunol 169(4):2034-43. [PubMed: 12165530]  [MGI Ref ID J:120206]

Whalen MJ; Carlos TM; Dixon CE; Robichaud P; Clark RS; Marion DW; Kochanek PM. 2000. Reduced brain edema after traumatic brain injury in mice deficient in P-selectin and intercellular adhesion molecule-1. J Leukoc Biol 67(2):160-8. [PubMed: 10670575]  [MGI Ref ID J:119906]

Wolyniec WW; De Sanctis GT; Nabozny G; Torcellini C; Haynes N; Joetham A; Gelfand EW; Drazen JM; Noonan TC. 1998. Reduction of antigen-induced airway hyperreactivity and eosinophilia in ICAM-1-deficient mice. Am J Respir Cell Mol Biol 18(6):777-85. [PubMed: 9618382]  [MGI Ref ID J:48598]

Xu H; Guan H; Zu G; Bullard D; Hanson J; Slater M; Elmets CA. 2001. The role of ICAM-1 molecule in the migration of Langerhans cells in the skin and regional lymph node. Eur J Immunol 31(10):3085-93. [PubMed: 11592085]  [MGI Ref ID J:72353]

Yamada M; Yanaba K; Hasegawa M; Matsushita Y; Horikawa M; Komura K; Matsushita T; Kawasuji A; Fujita T; Takehara K; Steeber DA; Tedder TF; Sato S. 2006. Regulation of local and metastatic host-mediated anti-tumour mechanisms by L-selectin and intercellular adhesion molecule-1. Clin Exp Immunol 143(2):216-27. [PubMed: 16412045]  [MGI Ref ID J:108135]

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Yukami T; Hasegawa M; Matsushita Y; Fujita T; Matsushita T; Horikawa M; Komura K; Yanaba K; Hamaguchi Y; Nagaoka T; Ogawa F; Fujimoto M; Steeber DA; Tedder TF; Takehara K; Sato S. 2007. Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. J Leukoc Biol 82(3):519-31. [PubMed: 17595378]  [MGI Ref ID J:124291]

Selptm1Bay related

Baker PJ; DuFour L; Dixon M; Roopenian DC. 2000. Adhesion molecule deficiencies increase Porphyromonas gingivalis-induced alveolar bone loss in mice. Infect Immun 68(6):3103-7. [PubMed: 10816450]  [MGI Ref ID J:62266]

Bartholdy C; Marker O; Thomsen AR. 2000. Migration of activated CD8(+) T lymphocytes to sites of viral infection does not require endothelial selectins. Blood 95(4):1362-9. [PubMed: 10666212]  [MGI Ref ID J:110273]

Bonasio R; Scimone ML; Schaerli P; Grabie N; Lichtman AH; von Andrian UH. 2006. Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nat Immunol 7(10):1092-100. [PubMed: 16951687]  [MGI Ref ID J:112629]

Bonig H; Priestley GV; Oehler V; Papayannopoulou T. 2007. Hematopoietic progenitor cells (HPC) from mobilized peripheral blood display enhanced migration and marrow homing compared to steady-state bone marrow HPC. Exp Hematol 35(2):326-34. [PubMed: 17258081]  [MGI Ref ID J:123189]

Briaud SA; Ding ZM; Michael LH; Entman ML; Daniel S; Ballantyne CM. 2001. Leukocyte trafficking and myocardial reperfusion injury in ICAM-1/P-selectin-knockout mice. Am J Physiol Heart Circ Physiol 280(1):H60-7. [PubMed: 11123218]  [MGI Ref ID J:68056]

Broide DH; Humber D; Sullivan S; Sriramarao P. 1998. Inhibition of eosinophil rolling and recruitment in P-selectin- and intracellular adhesion molecule-1-deficient mice [published erratum appears in Blood 1998 Jul 1;92(1):343] Blood 91(8):2847-56. [PubMed: 9531595]  [MGI Ref ID J:47461]

Broide DH; Sullivan S; Gifford T; Sriramarao P. 1998. Inhibition of pulmonary eosinophilia in P-selectin- and ICAM-1-deficient mice. Am J Respir Cell Mol Biol 18(2):218-25. [PubMed: 9476909]  [MGI Ref ID J:114264]

Bullard DC; Kunkel EJ; Kubo H; Hicks MJ; Lorenzo I; Doyle NA; Doerschuk CM; Ley K; Beaudet AL. 1996. Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J Exp Med 183(5):2329-36. [PubMed: 8642341]  [MGI Ref ID J:33135]

Bullard DC; Mobley JM; Justen JM; Sly LM; Chosay JG; Dunn CJ; Lindsey JR; Beaudet AL; Staite ND. 1999. Acceleration and increased severity of collagen-induced arthritis in P-selectin mutant mice. J Immunol 163(5):2844-9. [PubMed: 10453030]  [MGI Ref ID J:57086]

Carlow DA; Ziltener HJ. 2006. CD43 deficiency has no impact in competitive in vivo assays of neutrophil or activated T cell recruitment efficiency. J Immunol 177(9):6450-9. [PubMed: 17056577]  [MGI Ref ID J:140506]

Carrithers MD; Visintin I; Viret C; Janeway CS Jr. 2002. Role of genetic background in P selectin-dependent immune surveillance of the central nervous system. J Neuroimmunol 129(1-2):51-7. [PubMed: 12161020]  [MGI Ref ID J:102957]

Collins RG; Jung U; Ramirez M; Bullard DC; Hicks MJ; Smith CW; Ley K; Beaudet AL. 2001. Dermal and pulmonary inflammatory disease in E-selectin and P-selectin double-null mice is reduced in triple-selectin-null mice. Blood 98(3):727-35. [PubMed: 11468173]  [MGI Ref ID J:70682]

Collins RG; Velji R; Guevara NV; Hicks MJ; Chan L; Beaudet AL. 2000. P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice. J Exp Med 191(1):189-94. [PubMed: 10620617]  [MGI Ref ID J:59249]

Curtis JL; Sonstein J; Craig RA; Todt JC; Knibbs RN; Polak T; Bullard DC; Stoolman LM. 2002. Subset-specific reductions in lung lymphocyte accumulation following intratracheal antigen challenge in endothelial selectin-deficient mice. J Immunol 169(5):2570-9. [PubMed: 12193727]  [MGI Ref ID J:120687]

Doerschuk CM; Quinlan WM; Doyle NA; Bullard DC; Vestweber D; Jones ML; Takei F; Ward PA; Beaudet AL. 1996. The role of P-selectin and ICAM-1 in acute lung injury as determined using blocking antibodies and mutant mice. J Immunol 157(10):4609-14. [PubMed: 8906840]  [MGI Ref ID J:37197]

Eppihimer MJ; Russell J; Anderson DC; Wolitzky BA; Granger DN. 1997. Endothelial cell adhesion molecule expression in gene-targeted mice. Am J Physiol 273(4 Pt 2):H1903-8. [PubMed: 9362259]  [MGI Ref ID J:43907]

Eriksson EE. 2008. No detectable endothelial- or leukocyte-derived L-selectin ligand activity on the endothelium in inflamed cremaster muscle venules. J Leukoc Biol 84(1):93-103. [PubMed: 18381812]  [MGI Ref ID J:137752]

Evangelista V; Manarini S; Coller BS; Smyth SS. 2003. Role of P-selectin, beta2-integrins, and Src tyrosine kinases in mouse neutrophil-platelet adhesion. J Thromb Haemost 1(5):1048-54. [PubMed: 12871376]  [MGI Ref ID J:104023]

Falati S; Liu Q; Gross P; Merrill-Skoloff G; Chou J; Vandendries E; Celi A; Croce K; Furie BC; Furie B. 2003. Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin. J Exp Med 197(11):1585-98. [PubMed: 12782720]  [MGI Ref ID J:83734]

Forlow SB; Foley PL; Ley K. 2002. Severely reduced neutrophil adhesion and impaired host defense against fecal and commensal bacteria in CD18-/-P-selectin-/- double null mice. FASEB J 16(12):1488-96. [PubMed: 12374771]  [MGI Ref ID J:120011]

Forlow SB; Ley K. 2001. Selectin-independent leukocyte rolling and adhesion in mice deficient in E-, P-, and L-selectin and ICAM-1. Am J Physiol Heart Circ Physiol 280(2):H634-41. [PubMed: 11158961]  [MGI Ref ID J:68044]

Forlow SB; White EJ; Thomas KL; Bagby GJ; Foley PL; Ley K. 2002. T cell requirement for development of chronic ulcerative dermatitis in e- and p-selectin-deficient mice. J Immunol 169(9):4797-804. [PubMed: 12391189]  [MGI Ref ID J:79774]

Fujita T; Fujimoto M; Matsushita T; Shimada Y; Hasegawa M; Kuwano Y; Ogawa F; Takehara K; Sato S. 2007. Phase-Dependent Roles of E-Selectin during Chronic Contact Hypersensitivity Responses. Am J Pathol 170(5):1649-58. [PubMed: 17456770]  [MGI Ref ID J:121083]

Graciano AL; Bryant DD; White DJ; Horton J; Bowles NE; Giroir BP. 2001. Targeted disruption of ICAM-1, P-selectin genes improves cardiac function and survival in TNF-alpha transgenic mice. Am J Physiol Heart Circ Physiol 280(4):H1464-71. [PubMed: 11247755]  [MGI Ref ID J:108278]

Gregory JL; Morand EF; McKeown SJ; Ralph JA; Hall P; Yang YH; McColl SR; Hickey MJ. 2006. Macrophage migration inhibitory factor induces macrophage recruitment via CC chemokine ligand 2. J Immunol 177(11):8072-9. [PubMed: 17114481]  [MGI Ref ID J:140686]

Hafezi-Moghadam A; Thomas KL; Prorock AJ; Huo Y; Ley K. 2001. L-selectin shedding regulates leukocyte recruitment. J Exp Med 193(7):863-72. [PubMed: 11283159]  [MGI Ref ID J:120579]

He X; Schoeb TR; Panoskaltsis-Mortari A; Zinn KR; Kesterson RA; Zhang J; Samuel S; Hicks MJ; Hickey MJ; Bullard DC. 2006. Deficiency of P-selectin or P-selectin glycoprotein ligand-1 leads to accelerated development of glomerulonephritis and increased expression of CC chemokine ligand 2 in lupus-prone mice. J Immunol 177(12):8748-56. [PubMed: 17142777]  [MGI Ref ID J:127199]

Hickey MJ; Bullard DC; Issekutz A; James WG. 2002. Leukocyte-endothelial cell interactions are enhanced in dermal postcapillary venules of MRL/fas(lpr) (lupus-prone) mice: roles of P- and E-selectin. J Immunol 168(9):4728-36. [PubMed: 11971023]  [MGI Ref ID J:126009]

Hickey MJ; Granger DN; Kubes P. 1999. Molecular mechanisms underlying IL-4-induced leukocyte recruitment in vivo: a critical role for the alpha 4 integrin. J Immunol 163(6):3441-8. [PubMed: 10477616]  [MGI Ref ID J:119200]

Hicks AE; Abbitt KB; Dodd P; Ridger VC; Hellewell PG; Norman KE. 2005. The anti-inflammatory effects of a selectin ligand mimetic, TBC-1269, are not a result of competitive inhibition of leukocyte rolling in vivo. J Leukoc Biol 77(1):59-66. [PubMed: 15466915]  [MGI Ref ID J:95144]

Horikawa M; Fujimoto M; Hasegawa M; Matsushita T; Hamaguchi Y; Kawasuji A; Matsushita Y; Fujita T; Ogawa F; Takehara K; Steeber DA; Sato S. 2006. E- and P-selectins synergistically inhibit bleomycin-induced pulmonary fibrosis. Am J Pathol 169(3):740-9. [PubMed: 16936251]  [MGI Ref ID J:112363]

Huo Y; Schober A; Forlow SB; Smith DF; Hyman MC; Jung S; Littman DR; Weber C; Ley K. 2003. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med 9(1):61-7. [PubMed: 12483207]  [MGI Ref ID J:81164]

James WG; Bullard DC; Hickey MJ. 2003. Critical role of the alpha 4 integrin/VCAM-1 pathway in cerebral leukocyte trafficking in lupus-prone MRL/fas(lpr) mice. J Immunol 170(1):520-7. [PubMed: 12496439]  [MGI Ref ID J:127282]

Jones SP; Trocha SD; Strange MB; Granger DN; Kevil CG; Bullard DC; Lefer DJ. 2000. Leukocyte and endothelial cell adhesion molecules in a chronic murine model of myocardial reperfusion injury Am J Physiol Heart Circ Physiol 279(5):H2196-201. [PubMed: 11045953]  [MGI Ref ID J:65658]

Jung U; Ley K. 1999. Mice lacking two or all three selectins demonstrate overlapping and distinct functions for each selectin. J Immunol 162(11):6755-62. [PubMed: 10352295]  [MGI Ref ID J:55032]

Jung U; Ramos CL; Bullard DC; Ley K. 1998. Gene-targeted mice reveal importance of L-selectin-dependent rolling for neutrophil adhesion. Am J Physiol 274(5 Pt 2):H1785-91. [PubMed: 9612391]  [MGI Ref ID J:47723]

Kamochi M; Kamochi F; Kim YB; Sawh S; Sanders JM; Sarembock I; Green S; Young JS; Ley K; Fu SM; Rose CE Jr. 1999. P-selectin and ICAM-1 mediate endotoxin-induced neutrophil recruitment and injury to the lung and liver. Am J Physiol 277(2 Pt 1):L310-9. [PubMed: 10444525]  [MGI Ref ID J:56844]

Kerfoot SM; Long EM; Hickey MJ; Andonegui G; Lapointe BM; Zanardo RC; Bonder C; James WG; Robbins SM; Kubes P. 2004. TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease. J Immunol 173(11):7070-7. [PubMed: 15557205]  [MGI Ref ID J:94363]

Kerfoot SM; Norman MU; Lapointe BM; Bonder CS; Zbytnuik L; Kubes P. 2006. Reevaluation of P-selectin and alpha 4 integrin as targets for the treatment of experimental autoimmune encephalomyelitis. J Immunol 176(10):6225-34. [PubMed: 16670333]  [MGI Ref ID J:131757]

Kim MH; Carter PR; Harris NR. 2007. P-selectin-mediated adhesion impairs endothelium-dependent arteriolar dilation in hypercholesterolemic mice. Am J Physiol Heart Circ Physiol 292(1):H632-8. [PubMed: 16980348]  [MGI Ref ID J:119942]

Kohm AP; Miller SD. 2003. Role of ICAM-1 and P-selectin expression in the development and effector function of CD4+CD25+regulatory T cells. J Autoimmun 21(3):261-71. [PubMed: 14599851]  [MGI Ref ID J:86435]

Komura K; Hasegawa M; Hamaguchi Y; Saito E; Kaburagi Y; Yanaba K; Kawara S; Takehara K; Seki M; Steeber DA; Tedder TF; Sato S. 2003. Ultraviolet light exposure suppresses contact hypersensitivity by abrogating endothelial intercellular adhesion molecule-1 up-regulation at the elicitation site. J Immunol 171(6):2855-62. [PubMed: 12960307]  [MGI Ref ID J:85377]

Kulidjian AA; Issekutz AC; Issekutz TB. 2002. Differential role of E-selectin and P-selectin in T lymphocyte migration to cutaneous inflammatory reactions induced by cytokines. Int Immunol 14(7):751-60. [PubMed: 12096034]  [MGI Ref ID J:113536]

Kuligowski MP; Kitching AR; Hickey MJ. 2006. Leukocyte recruitment to the inflamed glomerulus: a critical role for platelet-derived P-selectin in the absence of rolling. J Immunol 176(11):6991-9. [PubMed: 16709860]  [MGI Ref ID J:131787]

Kunkel EJ; Chomas JE; Ley K. 1998. Role of primary and secondary capture for leukocyte accumulation in vivo. Circ Res 82(1):30-8. [PubMed: 9440702]  [MGI Ref ID J:114235]

Kunkel EJ; Jung U; Bullard DC; Norman KE; Wolitzky BA; Vestweber D; Beaudet AL; Ley K. 1996. Absence of trauma-induced leukocyte rolling in mice deficient in both P-selectin and intercellular adhesion molecule 1. J Exp Med 183(1):57-65. [PubMed: 8551244]  [MGI Ref ID J:31374]

Kupatt C; Wichels R; Horstkotte J; Krombach F; Habazettl H; Boekstegers P. 2002. Molecular mechanisms of platelet-mediated leukocyte recruitment during myocardial reperfusion. J Leukoc Biol 72(3):455-61. [PubMed: 12223512]  [MGI Ref ID J:124451]

Larbi KY; Dangerfield JP; Culley FJ; Marshall D; Haskard DO; Jose PJ; Williams TJ; Nourshargh S. 2003. P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses. J Leukoc Biol 73(1):65-73. [PubMed: 12525563]  [MGI Ref ID J:120684]

Laubli H; Stevenson JL; Varki A; Varki NM; Borsig L. 2006. L-selectin facilitation of metastasis involves temporal induction of Fut7-dependent ligands at sites of tumor cell arrest. Cancer Res 66(3):1536-42. [PubMed: 16452210]  [MGI Ref ID J:106671]

Lawson JA; Burns AR; Farhood A; Lynn Bajt M; Collins RG; Smith CW; Jaeschke H. 2000. Pathophysiologic importance of E- and L-selectin for neutrophil-induced liver injury during endotoxemia in mice. Hepatology 32(5):990-8. [PubMed: 11050049]  [MGI Ref ID J:106550]

Li Z; Burns AR; Rumbaut RE; Smith CW. 2007. {gamma}{delta} T Cells Are Necessary for Platelet and Neutrophil Accumulation in Limbal Vessels and Efficient Epithelial Repair after Corneal Abrasion. Am J Pathol 171(3):838-845. [PubMed: 17675580]  [MGI Ref ID J:124350]

Li Z; Burns AR; Smith CW. 2006. Two waves of neutrophil emigration in response to corneal epithelial abrasion: distinct adhesion molecule requirements. Invest Ophthalmol Vis Sci 47(5):1947-55. [PubMed: 16639002]  [MGI Ref ID J:108504]

Li Z; Rumbaut RE; Burns AR; Smith CW. 2006. Platelet response to corneal abrasion is necessary for acute inflammation and efficient re-epithelialization. Invest Ophthalmol Vis Sci 47(11):4794-802. [PubMed: 17065490]  [MGI Ref ID J:123092]

Lukacs NW; John A; Berlin A; Bullard DC; Knibbs R; Stoolman LM. 2002. E- and P-selectins are essential for the development of cockroach allergen-induced airway responses. J Immunol 169(4):2120-5. [PubMed: 12165540]  [MGI Ref ID J:120695]

Manka D; Collins RG; Ley K; Beaudet AL; Sarembock IJ. 2001. Absence of p-selectin, but not intercellular adhesion molecule-1, attenuates neointimal growth after arterial injury in apolipoprotein e-deficient mice. Circulation 103(7):1000-5. [PubMed: 11181476]  [MGI Ref ID J:103301]

Mizgerd JP; Bullard DC; Hicks MJ; Beaudet AL; Doerschuk CM. 1999. Chronic inflammatory disease alters adhesion molecule requirements for acute neutrophil emigration in mouse skin. J Immunol 162(9):5444-8. [PubMed: 10228023]  [MGI Ref ID J:112286]

Mori M; Salter JW; Vowinkel T; Krieglstein CF; Stokes KY; Granger DN. 2005. Molecular determinants of the prothrombogenic phenotype assumed by inflamed colonic venules. Am J Physiol Gastrointest Liver Physiol 288(5):G920-6. [PubMed: 15550557]  [MGI Ref ID J:98225]

Munoz FM; Hawkins EP; Bullard DC; Beaudet AL; Kaplan SL. 1997. Host defense against systemic infection with Streptococcus pneumoniae is impaired in E-, P-, and E-/P-selectin-deficient mice. J Clin Invest 100(8):2099-106. [PubMed: 9329976]  [MGI Ref ID J:101979]

Myers D Jr; Farris D; Hawley A; Wrobleski S; Chapman A; Stoolman L; Knibbs R; Strieter R; Wakefield T. 2002. Selectins influence thrombosis in a mouse model of experimental deep venous thrombosis. J Surg Res 108(2):212-21. [PubMed: 12505044]  [MGI Ref ID J:103110]

Norman KE; Katopodis AG; Thoma G; Kolbinger F; Hicks AE; Cotter MJ; Pockley AG; Hellewell PG. 2000. P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo Blood 96(10):3585-91. [PubMed: 11071658]  [MGI Ref ID J:65810]

Osterholzer JJ; Ames T; Polak T; Sonstein J; Moore BB; Chensue SW; Toews GB; Curtis JL. 2005. CCR2 and CCR6, but not endothelial selectins, mediate the accumulation of immature dendritic cells within the lungs of mice in response to particulate antigen. J Immunol 175(2):874-83. [PubMed: 16002685]  [MGI Ref ID J:100694]

Papayannopoulou T; Priestley GV; Nakamoto B; Zafiropoulos V; Scott LM. 2001. Molecular pathways in bone marrow homing: dominant role of alpha(4)beta(1) over beta(2)-integrins and selectins. Blood 98(8):2403-11. [PubMed: 11588037]  [MGI Ref ID J:115624]

Pelletier SD; Hong DS; Hu Y; Liu Y; Li S. 2004. Lack of the adhesion molecules P-selectin and intercellular adhesion molecule-1 accelerate the development of BCR/ABL-induced chronic myeloid leukemia-like myeloproliferative disease in mice. Blood 104(7):2163-71. [PubMed: 15213099]  [MGI Ref ID J:93772]

Pierangeli SS; Espinola RG; Liu X; Harris EN. 2001. Thrombogenic effects of antiphospholipid antibodies are mediated by intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and P-selectin. Circ Res 88(2):245-50. [PubMed: 11157679]  [MGI Ref ID J:115602]

Puri KD; Doggett TA; Huang CY; Douangpanya J; Hayflick JS; Turner M; Penninger J; Diacovo TG. 2005. The role of endothelial PI3Kgamma activity in neutrophil trafficking. Blood 106(1):150-7. [PubMed: 15769890]  [MGI Ref ID J:107472]

Raisanen-Sokolowski A; Glysing-Jensen T; Russell ME. 1999. Donor and recipient contributions of ICAM-1 and P-selectin in parenchymal rejection and graft arteriosclerosis: insights from double knockout mice. J Heart Lung Transplant 18(8):735-43. [PubMed: 10512519]  [MGI Ref ID J:59743]

Ramos CL; Huo Y; Jung U; Ghosh S; Manka DR; Sarembock IJ; Ley K. 1999. Direct demonstration of P-selectin- and VCAM-1-dependent mononuclear cell rolling in early atherosclerotic lesions of apolipoprotein E-deficient mice. Circ Res 84(11):1237-44. [PubMed: 10364560]  [MGI Ref ID J:55953]

Ruth JH; Amin MA; Woods JM; He X; Samuel S; Yi N; Haas CS; Koch AE; Bullard DC. 2005. Accelerated development of arthritis in mice lacking endothelial selectins. Arthritis Res Ther 7(5):R959-70. [PubMed: 16207337]  [MGI Ref ID J:112848]

Scalia R; Armstead VE; Minchenko AG; Lefer AM. 1999. Essential role of P-selectin in the initiation of the inflammatory response induced by hemorrhage and reinfusion. J Exp Med 189(6):931-8. [PubMed: 10075976]  [MGI Ref ID J:110938]

Schneeberger EE; Vu Q; LeBlanc BW; Doerschuk CM. 2000. The accumulation of dendritic cells in the lung is impaired in CD18-/- but not in ICAM-1-/- mutant mice. J Immunol 164(5):2472-8. [PubMed: 10679084]  [MGI Ref ID J:60566]

Singbartl K; Green SA; Ley K. 2000. Blocking P-selectin protects from ischemia/reperfusion-induced acute renal failure. FASEB J 14(1):48-54. [PubMed: 10627279]  [MGI Ref ID J:118770]

Sligh JE Jr; Ballantyne CM; Rich SS; Hawkins HK; Smith CW; Bradley A; Beaudet AL. 1993. Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc Natl Acad Sci U S A 90(18):8529-33. [PubMed: 8104338]  [MGI Ref ID J:14565]

Staite ND; Justen JM; Sly LM; Beaudet AL; Bullard DC. 1996. Inhibition of delayed-type contact hypersensitivity in mice deficient in both E-selectin and P-selectin. Blood 88(8):2973-9. [PubMed: 8874194]  [MGI Ref ID J:36036]

Stark MA; Huo Y; Burcin TL; Morris MA; Olson TS; Ley K. 2005. Phagocytosis of Apoptotic Neutrophils Regulates Granulopoiesis via IL-23 and IL-17. Immunity 22(3):285-94. [PubMed: 15780986]  [MGI Ref ID J:97026]

Steinhoff U; Klemm U; Greiner M; Bordasch K; Kaufmann SH. 1998. Altered intestinal immune system but normal antibacterial resistance in the absence of P-selectin and ICAM-1. J Immunol 160(12):6112-20. [PubMed: 9637528]  [MGI Ref ID J:48760]

Sullivan VV; Hawley AE; Farris DM; Knipp BS; Varga AJ; Wrobleski SK; Thanapron P; Eagleton MJ; Myers DD; Fowlkes JB; Wakefield TW. 2003. Decrease in fibrin content of venous thrombi in selectin-deficient mice. J Surg Res 109(1):1-7. [PubMed: 12591228]  [MGI Ref ID J:119317]

Sun G; Chang WL; Li J; Berney SM; Kimpel D; van der Heyde HC. 2003. Inhibition of platelet adherence to brain microvasculature protects against severe Plasmodium berghei malaria. Infect Immun 71(11):6553-61. [PubMed: 14573677]  [MGI Ref ID J:86276]

Tu L; Poe JC; Kadono T; Venturi GM; Bullard DC; Tedder TF; Steeber DA. 2002. A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo. J Immunol 169(4):2034-43. [PubMed: 12165530]  [MGI Ref ID J:120206]

Underhill GH; Kolli KP; Kansas GS. 2003. Complexity within the plasma cell compartment of mice deficient in both E- and P-selectin: implications for plasma cell differentiation. Blood 102(12):4076-83. [PubMed: 12881311]  [MGI Ref ID J:115681]

Underhill GH; Minges-Wols HA; Fornek JL; Witte PL; Kansas GS. 2002. IgG plasma cells display a unique spectrum of leukocyte adhesion and homing molecules. Blood 99(8):2905-12. [PubMed: 11929781]  [MGI Ref ID J:76083]

Vandendries ER; Hamilton JR; Coughlin SR; Furie B; Furie BC. 2007. Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis. Proc Natl Acad Sci U S A 104(1):288-92. [PubMed: 17190826]  [MGI Ref ID J:118749]

Verdrengh M; Erlandsson-Harris H; Tarkowski A. 2000. Role of selectins in experimental Staphylococcus aureus-induced arthritis. Eur J Immunol 30(6):1606-13. [PubMed: 10898496]  [MGI Ref ID J:62704]

Wang HB; Wang JT; Zhang L; Geng ZH; Xu WL; Xu T; Huo Y; Zhu X; Plow EF; Chen M; Geng JG. 2007. P-selectin primes leukocyte integrin activation during inflammation. Nat Immunol 8(8):882-892. [PubMed: 17632516]  [MGI Ref ID J:123408]

Whalen MJ; Carlos TM; Dixon CE; Robichaud P; Clark RS; Marion DW; Kochanek PM. 2000. Reduced brain edema after traumatic brain injury in mice deficient in P-selectin and intercellular adhesion molecule-1. J Leukoc Biol 67(2):160-8. [PubMed: 10670575]  [MGI Ref ID J:119906]

Wood KC; Hebbel RP; Granger DN. 2004. Endothelial cell P-selectin mediates a proinflammatory and prothrombogenic phenotype in cerebral venules of sickle cell transgenic mice. Am J Physiol Heart Circ Physiol 286(5):H1608-14. [PubMed: 14704223]  [MGI Ref ID J:95603]

Xu Y; Huo Y; Toufektsian MC; Ramos SI; Ma Y; Tejani AD; French BA; Yang Z. 2006. Activated platelets contribute importantly to myocardial reperfusion injury. Am J Physiol Heart Circ Physiol 290(2):H692-9. [PubMed: 16199480]  [MGI Ref ID J:106723]

Yanaba K; Kaburagi Y; Takehara K; Steeber DA; Tedder TF; Sato S. 2003. Relative contributions of selectins and intercellular adhesion molecule-1 to tissue injury induced by immune complex deposition. Am J Pathol 162(5):1463-73. [PubMed: 12707029]  [MGI Ref ID J:113592]

Zanardo RC; Bonder CS; Hwang JM; Andonegui G; Liu L; Vestweber D; Zbytnuik L; Kubes P. 2004. A down-regulatable E-selectin ligand is functionally important for PSGL-1-independent leukocyte-endothelial cell interactions. Blood 104(12):3766-73. [PubMed: 15304396]  [MGI Ref ID J:94829]

Zaph C; Scott P. 2003. Th1 cell-mediated resistance to cutaneous infection with Leishmania major is independent of P- and E-selectins. J Immunol 171(9):4726-32. [PubMed: 14568948]  [MGI Ref ID J:107364]

Zarbock A; Lowell CA; Ley K. 2007. Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1. Immunity 26(6):773-83. [PubMed: 17543554]  [MGI Ref ID J:123587]

Zarbock A; Singbartl K; Ley K. 2006. Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. J Clin Invest 116(12):3211-9. [PubMed: 17143330]  [MGI Ref ID J:117354]

Health & husbandry

Health & Colony Maintenance Information

Colony Maintenance

Diet Information LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $1900.00
*Price(s) in US dollars ($)

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $2470.00
*Price(s) in US dollars ($)

Additional Supply Details

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

  • This strain is included in the Induced Mutant Resource Colony collection.
  • Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions


See Terms of Use


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering and Purchasing Information

      Purchasing Information
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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries

Contracts Administration

phone:207-288-6470
fax:207-288-6655

JAX® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. THE LABORATORY EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

No Liability

In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.


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