Strain Name:

C.129S7(B6)-Ifngtm1Ts/J

Stock Number:

002286

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Mice homozygous for the Ifngtm1Ts targeted mutation appear normal in a "clean" environment but display reduced macrophage function in response to pathogens. Specifically, macrophages show impaired production of antimicrobial products and reduced expression of MHC II antigens. There is also uncontrollable proliferation of splenocytes from homozygotes in response to mitogens and alloantigens and a reduced resting natural killer cell activity.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a good breeder.
Specieslaboratory mouse
Background Strain BALB/c
Donor Strain B6;129S-Ifngtm1Ts (129S7 derived AB1 ES cell line +Hprt-bm2)
GenerationN9F1 (14-AUG-14)
Generation Definitions
 
Donating InvestigatorDr. Timothy Stewart,  

Appearance
albino
Related Genotype: A/A Tyrp1b/Tyrp1b Tyrc/Tyrc

Description
Mice homozygous for the Ifngtm1Ts targeted mutation are viable and fertile. Homozygotes appear normal in a "clean" environment but display reduced macrophage function in response to pathogens. Specifically, macrophages show impaired production of antimicrobial products and reduced expression of MHC II antigens. There is also uncontrollable proliferation of splenocytes from homozygotes in response to mitogens and alloantigens and a reduced resting natural killer cell activity.

Development
A 2-kb neomycin-resistance gene (neo?) was inserted into exon 2, which introduced a termination codon after the first 30 amino acids of the mature IFN-y protein. The targeting vector was transfected into AB-1 embryonic stem cells. Injection of the selected 48D clone with a disrupted allele into C57BL/6J blastocysts generated chimeric mice and heterozygous offspring were intercrossed to produce homozygotes for the targeted mutation of the IFN-y gene. The strain was backcrossed onto a BALB/c background for 6 generations by the donating investigator before the strain was imported to IMR.

Control Information

  Control
   000651 BALB/cJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Ifngtm1Ts allele
002287   B6.129S7-Ifngtm1Ts/J
008228   C3.129S7(B6)-Ifngtm1Ts/J
002575   NOD.129S7(B6)-Ifngtm1Ts/DvsJ
View Strains carrying   Ifngtm1Ts     (3 strains)

Strains carrying other alleles of Ifng
017581   B6.129S4-Ifngtm3.1Lky/J
009344   B6.Cg-Tg(tetO-Ifng)184Pop/J
017580   C.129S4(B6)-Ifngtm3.1Lky/J
View Strains carrying other alleles of Ifng     (3 strains)

Additional Web Information

JAX® NOTES, Fall 2008; 511. Ifng-deficient BALB/cJ mice play key role in lymphoma vaccine.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).
Malaria, Susceptibility to
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Aplastic Anemia   (IFNG)
Hepatitis C Virus, Susceptibility to   (IFNG)
Human Immunodeficiency Virus Type 1, Susceptibility to   (IFNG)
Mycobacterium Tuberculosis, Susceptibility to   (IFNG)
Tuberous Sclerosis 2; TSC2   (IFNG)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Ifngtm1Ts/Ifngtm1Ts

        C.129S7-Ifngtm1Ts
  • mortality/aging
  • increased susceptibility to bacterial infection induced morbidity/mortality
    • the LD50 for Listeria monocytogenes infection is 10 CFU compared to greater than 104 CFU for wild-type and heterozygous controls   (MGI Ref ID J:83180)
    • however the LD50 for a mutant strain of L. monocytogenes (DP-L1942) is similar in homozygous mice and controls   (MGI Ref ID J:83180)
    • following vaccination mice are able to develop resistance to L. monocytogenes infection   (MGI Ref ID J:83180)
  • increased susceptibility to parasitic infection induced morbidity/mortality
    • die within 9 days of inoculation with T. gondii (strain ME49) unlike controls which survive more than 30 days   (MGI Ref ID J:110826)
    • highly susceptible to the normally avirulent T. gondii isolate, ts4   (MGI Ref ID J:110826)
  • immune system phenotype
  • abnormal cytokine secretion
    • following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice   (MGI Ref ID J:110826)
    • increased interleukin-5 secretion
      • following infection with T. gondii (irradiate RH strain) splenocytes produce more IL-5 compared to similar cultures from wild-type mice   (MGI Ref ID J:110826)
  • abnormal humoral immune response
    • the magnitude of the OVA specific antibody is reduced   (MGI Ref ID J:45665)
    • following oral OVA exposure OVA antibody levels are essentially unchanged unlike in wild-type controls where oral exposure reduces antibody levels however, following oral OVA exposure OVA antibody levels are essentially unchanged unlike in wild-type controls where oral exposure reduces antibody levels   (MGI Ref ID J:45665)
    • abnormal immunoglobulin level
      • IgG responses are restricted to IgG1 and IgG2b   (MGI Ref ID J:45665)
  • abnormal immune tolerance
    • oral exposure to antigen (OVA) fails to reduce the responsiveness of mice to subsequent exposure to the same antigen   (MGI Ref ID J:45665)
    • increased susceptibility to experimental autoimmune encephalomyelitis
      • incidence rate (17 of 24 compared to 1 of 16 in controls) and severity are increased compared to contols immunization results in about a 30% mortality rate   (MGI Ref ID J:34161)
      • immunized mice display meningeal and perivascular inflammatory infiltrates in the spinal cord and brain similar to those seen in susceptible strains like SJL/J   (MGI Ref ID J:34161)
  • abnormal response to infection
    • following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice   (MGI Ref ID J:110826)
    • increased susceptibility to bacterial infection induced morbidity/mortality
      • the LD50 for Listeria monocytogenes infection is 10 CFU compared to greater than 104 CFU for wild-type and heterozygous controls   (MGI Ref ID J:83180)
      • however the LD50 for a mutant strain of L. monocytogenes (DP-L1942) is similar in homozygous mice and controls   (MGI Ref ID J:83180)
      • following vaccination mice are able to develop resistance to L. monocytogenes infection   (MGI Ref ID J:83180)
    • increased susceptibility to parasitic infection
      • dramatic increase in the number of infected cells expansion of the tissues infected following inoculation with Toxoplasma gondii (strain ME49)   (MGI Ref ID J:110826)
      • 5 days after inoculation with T. gondii (strain ME49) peritoneal exudates contain a more pronounced increase in the numbers of granulocytes, eosinophils, and mast cells compared to similarly infected wild-type controls   (MGI Ref ID J:110826)
      • IL-2 production in response to infection is similar to controls   (MGI Ref ID J:110826)
      • increased susceptibility to parasitic infection induced morbidity/mortality
        • die within 9 days of inoculation with T. gondii (strain ME49) unlike controls which survive more than 30 days   (MGI Ref ID J:110826)
        • highly susceptible to the normally avirulent T. gondii isolate, ts4   (MGI Ref ID J:110826)
  • tumorigenesis
  • *normal* tumorigenesis
    • unlike mice on a congenic C57BL/6 background, mice on a BALB/c background do not develop disseminated lymphomas   (MGI Ref ID J:77491)
    • increased lung adenocarcinoma incidence
      • in a few mice, with a very late onset   (MGI Ref ID J:77491)
      • all are well differentiated papillary adenocarcinomas   (MGI Ref ID J:77491)
    • increased tumor latency
      • in mice on a BALB/c background compared to mice on a C57BL/6 background   (MGI Ref ID J:77491)
  • hematopoietic system phenotype
  • abnormal immunoglobulin level
    • IgG responses are restricted to IgG1 and IgG2b   (MGI Ref ID J:45665)

Ifngtm1Ts/Ifngtm1Ts

        C.129S7(B6)-Ifngtm1Ts/J
  • mortality/aging
  • increased susceptibility to bacterial infection induced morbidity/mortality
    • die by 6 - 10 weeks after infection with the avirulent BCG strain of Mycobacterium bovis   (MGI Ref ID J:47459)
  • immune system phenotype
  • abnormal adaptive immunity   (MGI Ref ID J:115144)
    • abnormal NK cell physiology
      • decrease in the cytotoxicity of NK cells from mice primed with rIL12   (MGI Ref ID J:115144)
      • abnormal uterine NK cell physiology
        • decrease in the number of apoptotic uNK cells in the metrial gland afte day 10 of gestation   (MGI Ref ID J:56503)
        • uNK cells at implantation sites fail to become heavily granulated and have poorly developed golgi apparati   (MGI Ref ID J:56503)
    • abnormal cytotoxic T cell physiology
      • C26 cells induce slightly reduced CTL activity compared to the response in similarly treat wild-type mice   (MGI Ref ID J:115144)
    • abnormal macrophage physiology
      • exposure to rIL12 fails to prime macrophages against subsequent LPS exposure   (MGI Ref ID J:115144)
  • abnormal circulating cytokine level
    • increase in circulating levels of CSF3 after infection with BCG especially in moribund mice   (MGI Ref ID J:47459)
    • increased circulating interleukin-6 level
      • following infection with BCG   (MGI Ref ID J:47459)
  • abnormal cytokine secretion
    • lymphocytes form C25/Il12 cell primed mice produce about 3 fold higher levels of CSF2   (MGI Ref ID J:115144)
  • abnormal inflammatory response
    • in C26/Il12 tumors CD4+ T cells are more numerous relative to CD8+ T cells, in tumors in wild-type mice CD8+ T cells are more numerous   (MGI Ref ID J:115144)
  • abnormal spleen morphology   (MGI Ref ID J:115144)
    • abnormal spleen red pulp morphology
      • following infection with BCG, the normal follicular structure of the red and white pulp is lost and the red pulp is replaced with extramedullary hematopoietic tissue   (MGI Ref ID J:47459)
    • abnormal spleen white pulp morphology
      • following infection with BCG, the normal follicular structure of the red and white pulp is lost and the lymphocytic populations of the white pulp are replaced with sheets of leukocytes   (MGI Ref ID J:47459)
    • enlarged spleen
      • develop splenomegaly after infection with BCG   (MGI Ref ID J:47459)
    • pale spleen
      • spleens become paler as BCG infection proceeds   (MGI Ref ID J:47459)
  • abnormal uterine NK cell morphology
    • the golgi apparatus is poorly developed, the rough ER is disorganized, and numerous mitochondria are seen in uNK cell at implantation sites at gestational day 12   (MGI Ref ID J:56503)
    • increased uterine NK cell number
      • after day 10 of gestation increased numbers of uNK cells are found in the metrial gland compared to wild-type controls   (MGI Ref ID J:56503)
  • decreased susceptibility to parasitic infection
    • unlike mice on a C57BL/6 background, mice on a BALB/c background do not lose weight, show any change in stool consistency, or display heavy parasitic loads in the gastrointestinal tract over the course of a C. parvum infection   (MGI Ref ID J:50832)
  • increased leukocyte cell number
    • following infection with BCG   (MGI Ref ID J:47459)
    • increased granulocyte number
      • in the blood, bone marrow and spleen following infection with BCG   (MGI Ref ID J:47459)
    • increased monocyte cell number
      • following infection with BCG   (MGI Ref ID J:47459)
  • increased susceptibility to bacterial infection
    • following infection with BCG mice display an increased bacterial load throughout the infect in contrast to wild-type mice where bacterial numbers peak at 17 days post infection and decline thereafter   (MGI Ref ID J:47459)
    • following infection with BCG mice develop numerous granulomatous lesions in the liver and necrosis of both the liver and spleen   (MGI Ref ID J:47459)
    • increased susceptibility to bacterial infection induced morbidity/mortality
      • die by 6 - 10 weeks after infection with the avirulent BCG strain of Mycobacterium bovis   (MGI Ref ID J:47459)
  • behavior/neurological phenotype
  • abnormal response to new environment
    • the number of rearings is decreased in a novel environment   (MGI Ref ID J:54250)
    • unlike mice on a C57BL/6 background, no increase in the number of defecations in a novel environment or following a sound stimulus is seen in mice on a BALB/c background, compared to wild-type controls   (MGI Ref ID J:54250)
  • decreased vertical activity
    • in a novel environment   (MGI Ref ID J:54250)
  • increased fear-related response
    • prolonged freeze time following a startle stimulus relative to wild-type controls   (MGI Ref ID J:54250)
    • no increase in the number of defecations following a sound stimulus is seen in mice on a BALB/c background unlike mice on a C57BL/6 background   (MGI Ref ID J:54250)
  • tumorigenesis
  • altered tumor pathology
    • when injected with 5 x 105 C26/Il12 cells only a few mice are able to reject the tumor, in contrast 80 - 100% of wild-type mice reject the tumor   (MGI Ref ID J:115144)
    • in C26/Il12 derived tumors, tumor vessels are more numerous and thinner compared to vessels in tumors in wild-type mice   (MGI Ref ID J:115144)
  • decreased tumor latency
    • tumor onset is accelerated in 40% of mice injected with 5 x 104 C26 carcinoma cells transduced with Il12 genes (C26/Il12) compared to similarly treated wild-type mice   (MGI Ref ID J:115144)
    • however, no difference is detected when parental C26 cells are used   (MGI Ref ID J:115144)
  • reproductive system phenotype
  • abnormal maternal decidual layer morphology
    • after gestational day 10 the intercellular composition of the decidua changes suggesting accumulations of fluid and extracellular matrix, areas of necrosis are present and a lack of decidual cellularity is apparent   (MGI Ref ID J:56503)
    • abnormal uterine NK cell morphology
      • the golgi apparatus is poorly developed, the rough ER is disorganized, and numerous mitochondria are seen in uNK cell at implantation sites at gestational day 12   (MGI Ref ID J:56503)
      • increased uterine NK cell number
        • after day 10 of gestation increased numbers of uNK cells are found in the metrial gland compared to wild-type controls   (MGI Ref ID J:56503)
  • abnormal uterine NK cell physiology
    • decrease in the number of apoptotic uNK cells in the metrial gland afte day 10 of gestation   (MGI Ref ID J:56503)
    • uNK cells at implantation sites fail to become heavily granulated and have poorly developed golgi apparati   (MGI Ref ID J:56503)
  • decreased litter size
    • decrease in litter size and increase in the number of resorbed embryos in the first litter   (MGI Ref ID J:56503)
    • no difference in litter size or number of resorbed embryos is detected in subsequent pregnancies   (MGI Ref ID J:56503)
    • phenotype is independent of the genotype of the embryos   (MGI Ref ID J:56503)
  • homeostasis/metabolism phenotype
  • abnormal circulating cytokine level
    • increase in circulating levels of CSF3 after infection with BCG especially in moribund mice   (MGI Ref ID J:47459)
    • increased circulating interleukin-6 level
      • following infection with BCG   (MGI Ref ID J:47459)
  • embryogenesis phenotype
  • abnormal maternal decidual layer morphology
    • after gestational day 10 the intercellular composition of the decidua changes suggesting accumulations of fluid and extracellular matrix, areas of necrosis are present and a lack of decidual cellularity is apparent   (MGI Ref ID J:56503)
    • abnormal uterine NK cell morphology
      • the golgi apparatus is poorly developed, the rough ER is disorganized, and numerous mitochondria are seen in uNK cell at implantation sites at gestational day 12   (MGI Ref ID J:56503)
      • increased uterine NK cell number
        • after day 10 of gestation increased numbers of uNK cells are found in the metrial gland compared to wild-type controls   (MGI Ref ID J:56503)
  • hematopoietic system phenotype
  • abnormal NK cell physiology
    • decrease in the cytotoxicity of NK cells from mice primed with rIL12   (MGI Ref ID J:115144)
    • abnormal uterine NK cell physiology
      • decrease in the number of apoptotic uNK cells in the metrial gland afte day 10 of gestation   (MGI Ref ID J:56503)
      • uNK cells at implantation sites fail to become heavily granulated and have poorly developed golgi apparati   (MGI Ref ID J:56503)
  • abnormal cytotoxic T cell physiology
    • C26 cells induce slightly reduced CTL activity compared to the response in similarly treat wild-type mice   (MGI Ref ID J:115144)
  • abnormal macrophage physiology
    • exposure to rIL12 fails to prime macrophages against subsequent LPS exposure   (MGI Ref ID J:115144)
  • abnormal spleen morphology   (MGI Ref ID J:115144)
    • abnormal spleen red pulp morphology
      • following infection with BCG, the normal follicular structure of the red and white pulp is lost and the red pulp is replaced with extramedullary hematopoietic tissue   (MGI Ref ID J:47459)
    • abnormal spleen white pulp morphology
      • following infection with BCG, the normal follicular structure of the red and white pulp is lost and the lymphocytic populations of the white pulp are replaced with sheets of leukocytes   (MGI Ref ID J:47459)
    • enlarged spleen
      • develop splenomegaly after infection with BCG   (MGI Ref ID J:47459)
    • pale spleen
      • spleens become paler as BCG infection proceeds   (MGI Ref ID J:47459)
  • abnormal uterine NK cell morphology
    • the golgi apparatus is poorly developed, the rough ER is disorganized, and numerous mitochondria are seen in uNK cell at implantation sites at gestational day 12   (MGI Ref ID J:56503)
    • increased uterine NK cell number
      • after day 10 of gestation increased numbers of uNK cells are found in the metrial gland compared to wild-type controls   (MGI Ref ID J:56503)
  • extramedullary hematopoiesis
    • following infection with BCG   (MGI Ref ID J:47459)
  • increased leukocyte cell number
    • following infection with BCG   (MGI Ref ID J:47459)
    • increased granulocyte number
      • in the blood, bone marrow and spleen following infection with BCG   (MGI Ref ID J:47459)
    • increased monocyte cell number
      • following infection with BCG   (MGI Ref ID J:47459)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Ifngtm1Ts/Ifngtm1Ts

        involves: 129S7/SvEvBrd * C57BL/6
  • immune system phenotype
  • *normal* immune system phenotype
    • mice are able to clear infections of Pneumocystis carinii, similar to controls   (MGI Ref ID J:119206)
    • abnormal NK cell physiology
      • significantly lower resting splenic NK cell activity   (MGI Ref ID J:66802)
      • recruitment of NK cells to the liver by recombinant murine IL12 is impaired   (MGI Ref ID J:115033)
      • however, the recruitment of T cells by IL12 is not impaired   (MGI Ref ID J:115033)
    • abnormal macrophage physiology
      • macrophages from BCG infected mice fail to produce nitric oxide in response to LPS challenge   (MGI Ref ID J:66802)
      • macrophages from BCG infected mice exhibit reduced production of superoxide anion in response to PMA challenge   (MGI Ref ID J:66802)
      • abnormal MHC II cell surface expression on macrophages
        • macrophages from BCG infected mice exhibit reduced class II expression   (MGI Ref ID J:66802)
    • abnormal type IV hypersensitivity reaction
      • exposure to UVA and UVB fails to significantly reduce the UVB induced suppression of the type IV hypersensitivity reaction   (MGI Ref ID J:55740)
      • however, the type IV hypersensitivity reaction in the absence of UV exposure is similar to controls   (MGI Ref ID J:55740)
    • decreased length of allograft survival
      • reduced surival of cardiac grafts relative to controls   (MGI Ref ID J:44346)
    • decreased susceptibility to parasitic infection
      • mice infected with Plasmodium berghei ANKA are protected from development of experimental cerebral malaria and survive longer than wild-type mice   (MGI Ref ID J:189794)
      • however, IFNG-competent alpha+CD4+ T cells promote experimental cerebral malaria   (MGI Ref ID J:189794)
      • decreased susceptibility to parasitic infection induced morbidity/mortality
        • mice infected with Plasmodium berghei ANKA are protected from development of experimental cerebral malaria and survive longer than wild-type mice   (MGI Ref ID J:189794)
    • increased splenocyte proliferation
      • splenocytes from BCG infected mice exhibit increased proliferation in response to Con A   (MGI Ref ID J:66802)
    • increased susceptibility to bacterial infection
      • increased mortality following a sublethal dose of Mycobacterium bovis (BCG )   (MGI Ref ID J:66802)
  • tumorigenesis
  • decreased tumor incidence
    • tumor-bearing mice treated with Th-17-polarized cells from Tg(Tcra,Tcrb)9Rest cells show increased tumor rejection compared to controls   (MGI Ref ID J:138466)
  • increased metastatic potential
    • following treatment with alphaGalCer, mice fail to exhibit a reduction in the number of B16F10 tumors metastasizing to the lungs unlike similarly treated wild-type mice   (MGI Ref ID J:152785)
  • craniofacial phenotype
  • abnormal alveolar process morphology
    • modest increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks   (MGI Ref ID J:147935)
  • skeleton phenotype
  • abnormal alveolar process morphology
    • modest increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks   (MGI Ref ID J:147935)
  • hematopoietic system phenotype
  • abnormal NK cell physiology
    • significantly lower resting splenic NK cell activity   (MGI Ref ID J:66802)
    • recruitment of NK cells to the liver by recombinant murine IL12 is impaired   (MGI Ref ID J:115033)
    • however, the recruitment of T cells by IL12 is not impaired   (MGI Ref ID J:115033)
  • abnormal macrophage physiology
    • macrophages from BCG infected mice fail to produce nitric oxide in response to LPS challenge   (MGI Ref ID J:66802)
    • macrophages from BCG infected mice exhibit reduced production of superoxide anion in response to PMA challenge   (MGI Ref ID J:66802)
    • abnormal MHC II cell surface expression on macrophages
      • macrophages from BCG infected mice exhibit reduced class II expression   (MGI Ref ID J:66802)
  • increased splenocyte proliferation
    • splenocytes from BCG infected mice exhibit increased proliferation in response to Con A   (MGI Ref ID J:66802)
  • integument phenotype
  • abnormal skin physiology
    • following exposure to UVA and UVB mice fail to develop significant erythema unlike wild-type controls   (MGI Ref ID J:55740)
    • however, the increase in skin fold thickness in response to UVB or UVA and UVB exposure is not significantly different from controls   (MGI Ref ID J:55740)
  • cellular phenotype
  • increased splenocyte proliferation
    • splenocytes from BCG infected mice exhibit increased proliferation in response to Con A   (MGI Ref ID J:66802)
  • mortality/aging
  • decreased susceptibility to parasitic infection induced morbidity/mortality
    • mice infected with Plasmodium berghei ANKA are protected from development of experimental cerebral malaria and survive longer than wild-type mice   (MGI Ref ID J:189794)

Ifngtm1Ts/Ifngtm1Ts

        involves: 129S7/SvEvBrd
  • mortality/aging
  • increased susceptibility to bacterial infection induced morbidity/mortality
    • mean survival time following infecting with virulent Mycobacterium tuberculosis is 15 days compared to over 60 days for wild-type controls   (MGI Ref ID J:110856)
    • treatment with exogenous IFNG improves survival   (MGI Ref ID J:110856)
  • increased susceptibility to viral infection induced morbidity/mortality
    • more than 70% of mice infected on the cornea with herpes simplex virus type 1 (HSV-1) at a dose of 105 TCID50 (50% tissue culture infective dose) infectious particles die   (MGI Ref ID J:29170)
  • immune system phenotype
  • abnormal cytokine level
    • T cells from mice immunized with myelin oligodendrocyte glycoprotein (MOG) peptide show more IL-17a expressing cells and greater IL-17a production after MOG restimulation than controls; IL-4 is not detectable in these cells   (MGI Ref ID J:112600)
  • abnormal immunoglobulin level
    • in mice with acute or chronic HSV-1 infection the ratio of IgG2a to IgG1 is dramatically reduced compared to BALB/c wild-type mice   (MGI Ref ID J:29170)
    • increased IgG1 level
      • following infection with type A influenza   (MGI Ref ID J:110721)
  • abnormal response to infection
    • display an increased IgG1 antibody response to type A influenza infection   (MGI Ref ID J:110721)
    • 14 days after infection with virulent Mycobacterium tuberculosis serum levels of reactive nitrogen intermediates are very low, unlike in wild-type controls   (MGI Ref ID J:110856)
    • the magnitude of the delayed type hypersensitive response in mice after HSV-1 infection is reduced compared to BALB/c wild-type controls   (MGI Ref ID J:29170)
    • increased susceptibility to bacterial infection
      • at 14 days after infection with virulent Mycobacterium tuberculosis, 10- 100 fold more viable bacteria are found in the organs compared to organs of wild-type controls   (MGI Ref ID J:110856)
      • at 14 days after infection with virulent Mycobacterium tuberculosis, about 90% of the granulomas in the liver and 20% of the granulomas in the spleen are necrotic   (MGI Ref ID J:110856)
      • treatment with exogenous IFNG decreases the bacterial load   (MGI Ref ID J:110856)
      • increased susceptibility to bacterial infection induced morbidity/mortality
        • mean survival time following infecting with virulent Mycobacterium tuberculosis is 15 days compared to over 60 days for wild-type controls   (MGI Ref ID J:110856)
        • treatment with exogenous IFNG improves survival   (MGI Ref ID J:110856)
    • increased susceptibility to viral infection
      • at 5 - 8 days post infection mice develop more severe conjunctivitis, periocular skin lesions, corneal opacity, and anterior chamber exudate following infection with HSV-1 relative to wld-type BALB/c controls infected with a higher dose of virus   (MGI Ref ID J:29170)
      • infectious virus is detected up to 10 days post infection with HSV-1 in mutants compared to up to 4 or days post infection in wild-type BAL/c mice or littermate controls, respectively   (MGI Ref ID J:29170)
      • increased susceptibility to viral infection induced morbidity/mortality
        • more than 70% of mice infected on the cornea with herpes simplex virus type 1 (HSV-1) at a dose of 105 TCID50 (50% tissue culture infective dose) infectious particles die   (MGI Ref ID J:29170)
  • decreased susceptibility to type IV hypersensitivity reaction
    • the magnitude of the delayed type hypersensitive response in mice after HSV-1 infection is reduced compared to BALB/c wild-type controls   (MGI Ref ID J:29170)
  • impaired natural killer cell mediated cytotoxicity
    • activated splenic and liver NK cells are less efficient in their killing of 4T1 or Renca tumor target cells   (MGI Ref ID J:73948)
  • increased interleukin-17 secretion
    • following culturing of IL-17 producing T cells in vitro, IL-17 production is twice as high as in similarly treated wild-type cells   (MGI Ref ID J:132905)
  • vision/eye phenotype
  • corneal vascularization
    • corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice   (MGI Ref ID J:114973)
  • homeostasis/metabolism phenotype
  • abnormal cytokine level
    • T cells from mice immunized with myelin oligodendrocyte glycoprotein (MOG) peptide show more IL-17a expressing cells and greater IL-17a production after MOG restimulation than controls; IL-4 is not detectable in these cells   (MGI Ref ID J:112600)
  • cardiovascular system phenotype
  • corneal vascularization
    • corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice   (MGI Ref ID J:114973)
  • hematopoietic system phenotype
  • abnormal immunoglobulin level
    • in mice with acute or chronic HSV-1 infection the ratio of IgG2a to IgG1 is dramatically reduced compared to BALB/c wild-type mice   (MGI Ref ID J:29170)
    • increased IgG1 level
      • following infection with type A influenza   (MGI Ref ID J:110721)
  • impaired natural killer cell mediated cytotoxicity
    • activated splenic and liver NK cells are less efficient in their killing of 4T1 or Renca tumor target cells   (MGI Ref ID J:73948)

Ifngtm1Ts/Ifngtm1Ts

        B6.129S7-Ifngtm1Ts/J
  • mortality/aging
  • increased sensitivity to xenobiotic induced morbidity/mortality
    • increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls   (MGI Ref ID J:91927)
  • increased susceptibility to bacterial infection induced morbidity/mortality
    • die by 6 - 10 weeks after infection with the avirulent BCG strain of Mycobacterium bovis   (MGI Ref ID J:47459)
  • increased susceptibility to parasitic infection induced morbidity/mortality
    • most mice die by 9 days after infection with 1x106 Cryptosporidium parvum oocysts   (MGI Ref ID J:50832)
  • immune system phenotype
  • *normal* immune system phenotype
    • do not exhibit defects on either IgE isotype switch or IgE production   (MGI Ref ID J:114783)
    • abnormal circulating cytokine level
      • increase in circulating levels of CSF3 after infection with BCG especially in moribund mice   (MGI Ref ID J:47459)
      • increased circulating interleukin-6 level
        • following infection with BCG   (MGI Ref ID J:47459)
    • abnormal cytokine secretion   (MGI Ref ID J:120556)
      • decreased interferon-gamma secretion
        • splenocytes fail to produce IFN-gamma in response to H. pylori antigen stimulation   (MGI Ref ID J:120556)
      • decreased interleukin-10 secretion
        • splenocytes from Helicobacter pylori infected mice produce 4-fold less IL-10 when cultured in the presence of H. pylori antigen   (MGI Ref ID J:120556)
        • by bone marrow dendritic cells following LPS stimulation   (MGI Ref ID J:134949)
      • increased interleukin-12 secretion
        • by bone marrow dendritic cells following LPS stimulation   (MGI Ref ID J:134949)
      • increased interleukin-4 secretion
        • splenocytes from Helicobacter pylori infected mice produce significantly more IL-4 than splenocytes from wild-type controls when cultured in the presence of H. pylori antigen   (MGI Ref ID J:120556)
    • abnormal dendritic cell physiology
      • increase in IL12 and decrease in IL10 secretion following LPS stimulation   (MGI Ref ID J:134949)
      • abnormal Langerhans cell physiology
        • enhancement in hapten induced Langerhan cell migration to the draining lymph nodes   (MGI Ref ID J:134949)
      • abnormal dendritic cell antigen presentation
        • dendritic cells show a greater ability to stimulate T cell proliferation in vitro   (MGI Ref ID J:134949)
      • abnormal dendritic cell chemotaxis
        • enhancement in the ability of dendritic cells to transmigrate across a membrane in response to RANTES in vitro   (MGI Ref ID J:134949)
        • enhancement in LPS induced dendritic cell migration to the spleen   (MGI Ref ID J:134949)
    • abnormal humoral immune response
      • the magnitude of the OVA specific antibody response to subcutaneous OVA challenge is reduced   (MGI Ref ID J:45665)
      • however, following oral OVA exposure OVA antibody levels in response to subcutaneous OVA challenge are essentially unchanged unlike in wild-type controls where oral exposure reduces antibody levels   (MGI Ref ID J:45665)
      • abnormal immunoglobulin level
        • IgG responses are restricted to IgG1 and IgG2b   (MGI Ref ID J:45665)
    • abnormal immune tolerance
      • oral exposure to antigen (OVA) fails to reduce the responsiveness of mice to subsequent subcutaneous exposure to the same antigen   (MGI Ref ID J:45665)
    • abnormal macrophage chemotaxis
      • 5 days after muscle injury fewer macrophages are present at the injury site compared to similarly treated wild-type mice   (MGI Ref ID J:136628)
    • abnormal spleen morphology   (MGI Ref ID J:47459)
      • abnormal spleen red pulp morphology
        • following infection with BCG, the normal follicular structure of the red and white pulp is lost and the red pulp is replaced with extramedullary hematopoietic tissue   (MGI Ref ID J:47459)
      • abnormal spleen white pulp morphology
        • following infection with BCG, the normal follicular structure of the red and white pulp is lost and the lymphocytic populations of the white pulp are replaced with sheets of leukocytes   (MGI Ref ID J:47459)
      • enlarged spleen
        • develop splenomegaly after infection with BCG   (MGI Ref ID J:47459)
      • pale spleen
        • spleens become paler as BCG infection proceeds   (MGI Ref ID J:47459)
    • abnormal type IV hypersensitivity reaction
      • in OVA fed mice only a modest decrease in the delayed type hypersensitivity response to injected OVA is seen in contrast this reaction is strongly decreased in similarly treated wild-type controls   (MGI Ref ID J:45665)
      • increased susceptibility to type IV hypersensitivity reaction
        • display a more severe delayed type hypersensitivity reaction in response to sheep IgG   (MGI Ref ID J:118730)
    • decreased length of allograft survival
      • decrease in survival times of heart transplants from CBA mice after a 30 day course of anti-CD4 and anti-CD8 mAb   (MGI Ref ID J:44346)
      • only 10% of heart grafts survive more than 100 days compared to 36% of grafts in wild-type mice   (MGI Ref ID J:44346)
    • enlarged mesenteric lymph nodes
      • in C. parvum infected mice   (MGI Ref ID J:50832)
    • glomerulonephritis
      • increased susceptibility to induced accelerated antiglomerular basement membrane nephritis as determined by increased albuminuria and more severe pathological changes   (MGI Ref ID J:118730)
    • increased leukocyte cell number
      • following infection with BCG   (MGI Ref ID J:47459)
      • increased NK T cell number
        • unlike in wild-type mice, treatment with LPS and DGalN fails to decrease NK T cell numbers   (MGI Ref ID J:122801)
      • increased granulocyte number
        • in the blood, bone marrow and spleen following infection with BCG   (MGI Ref ID J:47459)
      • increased monocyte cell number
        • following infection with BCG   (MGI Ref ID J:47459)
    • increased susceptibility to bacterial infection
      • following infection with BCG mice display an increased bacterial load throughout the infect in contrast to wild-type mice where bacterial numbers peak at 17 days post infection and decline thereafter   (MGI Ref ID J:47459)
      • following infection with BCG mice develop numerous granulomatous lesions in the liver and necrosis of both the liver and spleen   (MGI Ref ID J:47459)
      • increased susceptibility to bacterial infection induced morbidity/mortality
        • die by 6 - 10 weeks after infection with the avirulent BCG strain of Mycobacterium bovis   (MGI Ref ID J:47459)
    • increased susceptibility to parasitic infection
      • mice on a C57BL/6 background lose weight and develop soft gelatinous stools over the course of a C. parvum infection while mice on a BALB/c background do not   (MGI Ref ID J:50832)
      • in C. parvum infected mice on a C57BL/6 background, but not on a BALB/c background, the gastrointestinal tract is heavily colonized with parasites, the small intestines are distended and filled with gelatinous fluid, mesenteric lymph nodes are enlarged and in about 50% of mice gallbladders are enlarged   (MGI Ref ID J:50832)
      • increased susceptibility to parasitic infection induced morbidity/mortality
        • most mice die by 9 days after infection with 1x106 Cryptosporidium parvum oocysts   (MGI Ref ID J:50832)
    • stomach inflammation
      • 5 weeks after Helicobacter pylori infection, mice have a significantly decreased gastritis inflammation score compared to infected wild-type mice   (MGI Ref ID J:120556)
  • behavior/neurological phenotype
  • abnormal response to new environment
    • increase in the number of defecations in a novel environment compared to wild-type controls in mice on a C57BL/6 background but not in mice on a BALB/c background   (MGI Ref ID J:54250)
    • the number of rearings is decreased in a novel environment   (MGI Ref ID J:54250)
    • initial locomotor activity is decreased; however, overall distance traveled is not different from controls   (MGI Ref ID J:54250)
  • decreased vertical activity
    • in a novel environment   (MGI Ref ID J:54250)
  • increased fear-related response
    • increase in the number of defecations following a sound stimulus suggesting an enhancement of fear related responses in mice on a C57BL/6 background but not in mice on a BALB/c background   (MGI Ref ID J:54250)
    • prolonged freeze time and longer time to return to normal open field activity patterns following a startle stimulus relative to wild-type controls   (MGI Ref ID J:54250)
    • make fewer entries and spend less time in the open arms of an elevated maze relative to wild-type controls   (MGI Ref ID J:54250)
  • cellular phenotype
  • abnormal dendritic cell chemotaxis
    • enhancement in the ability of dendritic cells to transmigrate across a membrane in response to RANTES in vitro   (MGI Ref ID J:134949)
    • enhancement in LPS induced dendritic cell migration to the spleen   (MGI Ref ID J:134949)
  • abnormal macrophage chemotaxis
    • 5 days after muscle injury fewer macrophages are present at the injury site compared to similarly treated wild-type mice   (MGI Ref ID J:136628)
  • abnormal redox activity
    • unlike in wild-type mice, treatment with LPS and DGalN or TNF-alpha and interferon-gamma fails to increase the production of reactive oxygen species in hepatocytes   (MGI Ref ID J:122801)
  • renal/urinary system phenotype
  • abnormal urine homeostasis
    • 1 day after induction of accelerated antiglomerular basement membrane nephritis no increase in total urinary nitrate or nitrate levels is detected unlike in similarly treated wild-type controls   (MGI Ref ID J:118730)
    • albuminuria
      • increase in albuminuria on days 2, 3,and 4 following induction of accelerated antiglomerular basement membrane nephritis   (MGI Ref ID J:118730)
  • glomerulonephritis
    • increased susceptibility to induced accelerated antiglomerular basement membrane nephritis as determined by increased albuminuria and more severe pathological changes   (MGI Ref ID J:118730)
  • homeostasis/metabolism phenotype
  • abnormal circulating cytokine level
    • increase in circulating levels of CSF3 after infection with BCG especially in moribund mice   (MGI Ref ID J:47459)
    • increased circulating interleukin-6 level
      • following infection with BCG   (MGI Ref ID J:47459)
  • abnormal nitric oxide homeostasis
    • unlike in wild-type mice, treatment with LPS and DGalN fails to increase nitric oxide levels   (MGI Ref ID J:122801)
  • abnormal response to injury
    • decrease in the number and area of regenerating muscle fibers 5 and 10 days after muscle injury   (MGI Ref ID J:136628)
    • fibrotic lesions are sometimes seen after injury   (MGI Ref ID J:136628)
    • 5 days after muscle injury fewer macrophages are present at the injury site compared to similarly treated wild-type mice   (MGI Ref ID J:136628)
    • decreased susceptibility to injury
      • following a 48 h exposure to hyperoxia (98-99% oxygen) neutrophil migration into the lung air space and the increase in pulmonary alveolar permeability are decreased indicating a decrease susceptibility to the early phase of hyperoxia induced lung injury   (MGI Ref ID J:108148)
      • however, after 84 h of exposure to hyperoxia these measures are not different from similarly exposed to wild-type controls   (MGI Ref ID J:108148)
  • abnormal urine homeostasis
    • 1 day after induction of accelerated antiglomerular basement membrane nephritis no increase in total urinary nitrate or nitrate levels is detected unlike in similarly treated wild-type controls   (MGI Ref ID J:118730)
    • albuminuria
      • increase in albuminuria on days 2, 3,and 4 following induction of accelerated antiglomerular basement membrane nephritis   (MGI Ref ID J:118730)
  • increased sensitivity to xenobiotic induced morbidity/mortality
    • increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls   (MGI Ref ID J:91927)
  • skeletal muscle fibrosis
    • fibrotic lesions are sometimes seen after injury   (MGI Ref ID J:136628)
  • muscle phenotype
  • impaired skeletal muscle regeneration
    • decrease in the number and area of regenerating fibers 5 and 10 days after injury   (MGI Ref ID J:136628)
    • fibrotic lesions are sometimes seen after injury   (MGI Ref ID J:136628)
    • however, prior to injury no difference in muscle fiber morphology are detected   (MGI Ref ID J:136628)
  • skeletal muscle fibrosis
    • fibrotic lesions are sometimes seen after injury   (MGI Ref ID J:136628)
  • digestive/alimentary phenotype
  • stomach inflammation
    • 5 weeks after Helicobacter pylori infection, mice have a significantly decreased gastritis inflammation score compared to infected wild-type mice   (MGI Ref ID J:120556)
  • hematopoietic system phenotype
  • abnormal immunoglobulin level
    • IgG responses are restricted to IgG1 and IgG2b   (MGI Ref ID J:45665)
  • abnormal macrophage chemotaxis
    • 5 days after muscle injury fewer macrophages are present at the injury site compared to similarly treated wild-type mice   (MGI Ref ID J:136628)
  • abnormal spleen morphology   (MGI Ref ID J:47459)
    • abnormal spleen red pulp morphology
      • following infection with BCG, the normal follicular structure of the red and white pulp is lost and the red pulp is replaced with extramedullary hematopoietic tissue   (MGI Ref ID J:47459)
    • abnormal spleen white pulp morphology
      • following infection with BCG, the normal follicular structure of the red and white pulp is lost and the lymphocytic populations of the white pulp are replaced with sheets of leukocytes   (MGI Ref ID J:47459)
    • enlarged spleen
      • develop splenomegaly after infection with BCG   (MGI Ref ID J:47459)
    • pale spleen
      • spleens become paler as BCG infection proceeds   (MGI Ref ID J:47459)
  • extramedullary hematopoiesis
    • following infection with BCG   (MGI Ref ID J:47459)
  • increased leukocyte cell number
    • following infection with BCG   (MGI Ref ID J:47459)
    • increased NK T cell number
      • unlike in wild-type mice, treatment with LPS and DGalN fails to decrease NK T cell numbers   (MGI Ref ID J:122801)
    • increased granulocyte number
      • in the blood, bone marrow and spleen following infection with BCG   (MGI Ref ID J:47459)
    • increased monocyte cell number
      • following infection with BCG   (MGI Ref ID J:47459)

Ifngtm1Ts/Ifngtm1Ts

        B6.129S7-Ifngtm1Ts
  • mortality/aging
  • increased susceptibility to parasitic infection induced morbidity/mortality
    • sudden death occurs 5 to 7 weeks after infection with Leishmania major   (MGI Ref ID J:18801)
    • die earlier after inoculation with Toxoplasma gondii (strain ME49) compared to wild-type controls   (MGI Ref ID J:110826)
  • increased susceptibility to viral infection induced morbidity/mortality
    • higher mortality is seen following infection with JHMV compared to wild-type controls   (MGI Ref ID J:112048)
  • premature death
    • in mice on a C57BL/6 background compared to mice on a BALB/c background   (MGI Ref ID J:77491)
  • tumorigenesis
  • decreased tumor latency
    • in mice on a C57BL/6 background compared to mice on a BALB/c background   (MGI Ref ID J:77491)
  • increased lymphoma incidence
    • 50% of mice on a congenic C57BL/5 background develop disseminated lymphomas compared to 0% of mice on a congenic BALB/c background   (MGI Ref ID J:77491)
    • most lymphomas are diffuse large cell lymphomas   (MGI Ref ID J:77491)
    • increased T cell derived lymphoma incidence
      • in a few mice   (MGI Ref ID J:77491)
  • increased sarcoma incidence
    • in a few mice   (MGI Ref ID J:77491)
  • immune system phenotype
  • abnormal B cell physiology
    • immature B cells fail to be excluded from the lymph nodes   (MGI Ref ID J:112084)
    • abnormal immunoglobulin level   (MGI Ref ID J:18801)
      • decreased IgG2a level
        • after infection with Leishmania major   (MGI Ref ID J:18801)
      • decreased IgG3 level
        • after infection with Leishmania major   (MGI Ref ID J:18801)
      • increased IgE level
        • after infection with Leishmania major   (MGI Ref ID J:18801)
      • increased IgG1 level
        • after infection with Leishmania major   (MGI Ref ID J:18801)
        • 5-fold increase in the serum levels of JHMV specific IgG1 at 14 days post infection compared to infected wild-type controls   (MGI Ref ID J:112048)
  • abnormal cytokine secretion
    • after infection with Leishmania major the number of lymphocytes producing IL4 increases unlike in control mice where the number of lymphocytes producing IFNG increases   (MGI Ref ID J:18801)
    • following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice   (MGI Ref ID J:110826)
    • increased interleukin-10 secretion
      • cervical lymph node cells from JHMV infected mice (7 days post infection) secrete more IL10 in response to JHMV antigen compared to cells from similarly infected wild-type mice   (MGI Ref ID J:112048)
    • increased interleukin-2 secretion
      • cervical lymph node cells from JHMV infected mice secrete more IL2 in response to JHMV antigen compared to cells from similarly infected wild-type mice   (MGI Ref ID J:112048)
    • increased interleukin-5 secretion
      • cervical lymph node cells from JHMV infected mice (7 days post infection) secrete more IL5 in response to JHMV antigen compared to cells from similarly infected wild-type mice   (MGI Ref ID J:112048)
  • abnormal lymph node cell ratio
    • significant increase in the numbers of immature B cells in the lymph nodes   (MGI Ref ID J:112084)
  • abnormal response to infection
    • after infection with Leishmania major mice display minimal Th1 type responses and increased Th2 type responses   (MGI Ref ID J:18801)
    • after infection with Leishmania major levels of IgG1 and IgE are increased while levels of IgG2a and IgG3 remain low   (MGI Ref ID J:18801)
    • following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice   (MGI Ref ID J:110826)
    • increased susceptibility to parasitic infection
      • develop progressive infection characterized by large lesions at the site of inoculation and sudden death 5 to 7 weeks after infection with Leishmania major   (MGI Ref ID J:18801)
      • numbers of parasites present in the footpads are substantially increased compared to wild-type and heterozygous controls   (MGI Ref ID J:18801)
      • increased susceptibility to parasitic infection induced morbidity/mortality
        • sudden death occurs 5 to 7 weeks after infection with Leishmania major   (MGI Ref ID J:18801)
        • die earlier after inoculation with Toxoplasma gondii (strain ME49) compared to wild-type controls   (MGI Ref ID J:110826)
    • increased susceptibility to viral infection
      • following infection with the JHM strain of mouse hepatitis virus (JHMV) mice display a slower clinical recovery and higher viral titers in the central nervous system compared to wild-type controls   (MGI Ref ID J:112048)
      • however, no differences are found in JHMV specific cytotoxic T lymphocyte activity   (MGI Ref ID J:112048)
      • at 14 days post infection with JHMV a 10 fold increase in the number of viral antigen positive cells is detected in the brain with most of the infected cells being oligodendrocytes   (MGI Ref ID J:112048)
      • increased susceptibility to viral infection induced morbidity/mortality
        • higher mortality is seen following infection with JHMV compared to wild-type controls   (MGI Ref ID J:112048)
  • abnormal response to transplant
    • after immunosuppressive treatment (anti-CD4 and anti-CD8 mAbs) allografts (BALB/c, H2-Ab1bm12 continue to display myocardial rejection at week 12 but do not display graft arterial disease, in contrast wild-type mice at week 12 display low levels of rejection but develop coronary arteriopathy   (MGI Ref ID J:42090)
  • increased CD8-positive, alpha-beta T cell number
    • increase in the number of CD8+ cells in the white matter tracts of JHMV infected mice compared to similarly infected wild-type controls at 7 and 14 days post infection   (MGI Ref ID J:112048)
  • hematopoietic system phenotype
  • abnormal B cell physiology
    • immature B cells fail to be excluded from the lymph nodes   (MGI Ref ID J:112084)
    • abnormal immunoglobulin level   (MGI Ref ID J:18801)
      • decreased IgG2a level
        • after infection with Leishmania major   (MGI Ref ID J:18801)
      • decreased IgG3 level
        • after infection with Leishmania major   (MGI Ref ID J:18801)
      • increased IgE level
        • after infection with Leishmania major   (MGI Ref ID J:18801)
      • increased IgG1 level
        • after infection with Leishmania major   (MGI Ref ID J:18801)
        • 5-fold increase in the serum levels of JHMV specific IgG1 at 14 days post infection compared to infected wild-type controls   (MGI Ref ID J:112048)
  • increased CD8-positive, alpha-beta T cell number
    • increase in the number of CD8+ cells in the white matter tracts of JHMV infected mice compared to similarly infected wild-type controls at 7 and 14 days post infection   (MGI Ref ID J:112048)

Ifngtm1Ts/Ifngtm1Ts

        involves: 129S7/SvEvBrd * C57BL/6J
  • mortality/aging
  • increased susceptibility to bacterial infection induced morbidity/mortality
    • after infection with a normally sublethal dose of the virulent Erdam strain of Mycobacterium tuberculosis mice become severely ill and need to be euthanized   (MGI Ref ID J:15723)
  • immune system phenotype
  • increased susceptibility to bacterial infection
    • following infection with a sublethal dose of the virulent Erdam strain of Mycobacterium tuberculosis mice develop widespread infection with high numbers of bacteria in multiple tissues and obvious bacteremia   (MGI Ref ID J:15723)
    • by 4 weeks after aerosol infection with the virulent Erdam strain of Mycobacterium tuberculosis mice display multifocal necrotic areas contain high numbers of bacteria in the spleen, liver, lungs and kidneys   (MGI Ref ID J:15723)
    • increased susceptibility to bacterial infection induced morbidity/mortality
      • after infection with a normally sublethal dose of the virulent Erdam strain of Mycobacterium tuberculosis mice become severely ill and need to be euthanized   (MGI Ref ID J:15723)

Ifngtm1Ts/Ifngtm1Ts

        involves: 129S7/SvEvBrd * NOD
  • immune system phenotype
  • *normal* immune system phenotype
    • at generation N4 no difference is seen in the time course of diabetes development in females unlike in mice at generation N7   (MGI Ref ID J:33427)

Ifngtm1Ts/Ifngtm1Ts

        involves: 129S7/SvEvBrd * BALB/c
  • immune system phenotype
  • *normal* immune system phenotype
    • no difference in survival, tissue damage or spread of infection following infection with the opportunistic fungal pathogen Candida albicans is detected relative to wild-type controls   (MGI Ref ID J:39881)
    • altered susceptibility to infection
      • mice are able to clear infectious Murine gammaherpesvirus 68 (MHV-68) from their lungs but with a slight delay relative wild-type mice   (MGI Ref ID J:39478)
      • no differences are detected in the frequency of latently infected cells, the generation of cytotoxic T cells, the infection induced cytokine profile, or the recruitment or proliferation of cells into inflammatory sites   (MGI Ref ID J:39478)
    • decreased IgE level
      • ovalbumin challenge fails to significantly potentiate ovalbumin specific IgE levels, unlike in wild-type controls   (MGI Ref ID J:114213)
    • decreased inflammatory response
      • the eosinophilic response in ovalbumin challenged mice is reduced compared to wild-type controls   (MGI Ref ID J:114213)
  • respiratory system phenotype
  • decreased airway responsiveness
    • ovalbumin challenge fails to induce airway hyperresponsiveness unlike in wild-type mice   (MGI Ref ID J:114213)
  • increased airway responsiveness
    • in saline challenged mice relative to wild-type controls   (MGI Ref ID J:114213)
  • hematopoietic system phenotype
  • decreased IgE level
    • ovalbumin challenge fails to significantly potentiate ovalbumin specific IgE levels, unlike in wild-type controls   (MGI Ref ID J:114213)

Ifngtm1Ts/Ifngtm1Ts

        involves: 129S7/SvEvBrd * A/WySn * C57BL/10SnSg * Swiss
  • immune system phenotype
  • decreased IgG level
    • decrease in the induction of IgG in response to low levels of antigen ((4-hydroxy-3 nitrophenyl)acetyl)   (MGI Ref ID J:119207)
    • decreased IgG2a level
      • following exposure to HgCl2 for 4 weeks, relative to similarly treated wild-type and heterozygous mice   (MGI Ref ID J:119207)
  • decreased susceptibility to autoimmune disorder
    • resistant to mercury induced autoimmune response   (MGI Ref ID J:119207)
  • increased IgG1 level
    • relative to wild-type controls   (MGI Ref ID J:119207)
    • however, mercury treatment does not result in an increase in IgG1 levels   (MGI Ref ID J:119207)
  • homeostasis/metabolism phenotype
  • decreased physiological sensitivity to xenobiotic
    • resistant to mercury induced autoimmune response   (MGI Ref ID J:119207)
  • hematopoietic system phenotype
  • decreased IgG level
    • decrease in the induction of IgG in response to low levels of antigen ((4-hydroxy-3 nitrophenyl)acetyl)   (MGI Ref ID J:119207)
    • decreased IgG2a level
      • following exposure to HgCl2 for 4 weeks, relative to similarly treated wild-type and heterozygous mice   (MGI Ref ID J:119207)
  • increased IgG1 level
    • relative to wild-type controls   (MGI Ref ID J:119207)
    • however, mercury treatment does not result in an increase in IgG1 levels   (MGI Ref ID J:119207)
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Ifngtm1Ts related

Cancer Research
Growth Factors/Receptors/Cytokines

Hematological Research
Immunological Defects

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines
Immunodeficiency
      multiple immune defects
Inflammation

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ifngtm1Ts
Allele Name targeted mutation 1, Timothy Stewart
Allele Type Targeted (Null/Knockout)
Common Name(s) GKO; IFN-g KO; IFN-gamma KO; IFN-gamma-; IFN-gammatm1Ts; IFN-gammaKO; IFNgamma KO; IFNgamma-; Ifn-gtm1Ts; Ifntm/Ts; Ifngtm1Ts; Ifngtm1Ts; ifgtm1; ifntm1Ts; ifng-;
Mutation Made ByDr. Timothy Stewart,  
Strain of Origin129S7/SvEvBrd-Hprt<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt<+>
Gene Symbol and Name Ifng, interferon gamma
Chromosome 10
Gene Common Name(s) IFG; IFI; IFN-gamma; IFNG2; Ifg;
Molecular Note Insertion of a neomycin gene into exon 2, which introduced a termination codon after the first 30 amino acids of the mature protein. [MGI Ref ID J:66802]

Genotyping

Genotyping Information

Genotyping Protocols

Ifngtm1Ts, High Resolution Melting
Ifngtm1Ts, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Dalton DK; Pitts-Meek S; Keshav S; Figari IS; Bradley A; Stewart TA. 1993. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes [see comments] Science 259(5102):1739-42. [PubMed: 8456300]  [MGI Ref ID J:66802]

Additional References

Amiri P; Haak-Frendscho M; Robbins K; McKerrow JH; Stewart T; Jardieu P. 1994. Anti-immunoglobulin E treatment decreases worm burden and egg production in Schistosoma mansoni-infected normal and interferon gamma knockout mice. J Exp Med 180(1):43-51. [PubMed: 8006599]  [MGI Ref ID J:18740]

Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. [PubMed: 15153508]  [MGI Ref ID J:90518]

Cooper AM; Dalton DK; Stewart TA; Griffin JP; Russell DG; Orme IM. 1993. Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med 178(6):2243-7. [PubMed: 8245795]  [MGI Ref ID J:15723]

Hata H; Sakaguchi N; Yoshitomi H; Iwakura Y; Sekikawa K; Azuma Y; Kanai C; Moriizumi E; Nomura T; Nakamura T; Sakaguchi S. 2004. Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. J Clin Invest 114(4):582-8. [PubMed: 15314695]  [MGI Ref ID J:92002]

Metcalf D; Alexander WS; Ryan PJ; Mifsud S; Di Rago L. 2001. Production of colony-stimulating factors and il-5 by organs from three types of mice with inflammatory disease due to loss of the suppressor of cytokine signaling-1. J Immunol 167(8):4661-7. [PubMed: 11591796]  [MGI Ref ID J:72058]

Murphy EA; Sathiyaseelan J; Parent MA; Zou B; Baldwin CL. 2001. Interferon-gamma is crucial for surviving a Brucella abortus infection in both resistant C57BL/6 and susceptible BALB/c mice. Immunology 103(4):511-8. [PubMed: 11529943]  [MGI Ref ID J:71148]

Quaglino E; Iezzi M; Mastini C; Amici A; Pericle F; Di Carlo E; Pupa SM; De Giovanni C; Spadaro M; Curcio C; Lollini PL; Musiani P; Forni G; Cavallo F. 2004. Electroporated DNA vaccine clears away multifocal mammary carcinomas in her-2/neu transgenic mice. Cancer Res 64(8):2858-64. [PubMed: 15087404]  [MGI Ref ID J:89875]

Rutigliano JA; Graham BS. 2004. Prolonged production of TNF-alpha exacerbates illness during respiratory syncytial virus infection. J Immunol 173(5):3408-17. [PubMed: 15322205]  [MGI Ref ID J:92711]

Savinov AY; Wong FS; Chervonsky AV. 2001. IFN-gamma Affects Homing of Diabetogenic T Cells. J Immunol 167(11):6637-43. [PubMed: 11714835]  [MGI Ref ID J:72818]

Shi X; Cao S; Mitsuhashi M; Xiang Z; Ma X. 2004. Genome-wide analysis of molecular changes in IL-12-induced control of mammary carcinoma via IFN-gamma-independent mechanisms. J Immunol 172(7):4111-22. [PubMed: 15034023]  [MGI Ref ID J:88715]

Smith LM; Bonafonte MT; Mead JR. 2000. Cytokine expression and specific lymphocyte proliferation in two strains of Cryptosporidium parvum-infected gamma-interferon knockout mice. J Parasitol 86(2):300-7. [PubMed: 10780549]  [MGI Ref ID J:62349]

Woolard MD; Hodge LM; Jones HP; Schoeb TR; Simecka JW. 2004. The upper and lower respiratory tracts differ in their requirement of IFN-gamma and IL-4 in controlling respiratory mycoplasma infection and disease. J Immunol 172(11):6875-83. [PubMed: 15153506]  [MGI Ref ID J:90522]

Zaalouk TK; Bajaj-Elliott M; George JT; McDonald V. 2004. Differential regulation of beta-defensin gene expression during Cryptosporidium parvum infection. Infect Immun 72(5):2772-9. [PubMed: 15102787]  [MGI Ref ID J:89473]

Ifngtm1Ts related

Aachoui Y; Leaf IA; Hagar JA; Fontana MF; Campos CG; Zak DE; Tan MH; Cotter PA; Vance RE; Aderem A; Miao EA. 2013. Caspase-11 protects against bacteria that escape the vacuole. Science 339(6122):975-8. [PubMed: 23348507]  [MGI Ref ID J:193387]

Abdullah Z; Geiger S; Nino-Castro A; Bottcher JP; Muraliv E; Gaidt M; Schildberg FA; Riethausen K; Flossdorf J; Krebs W; Chakraborty T; Kurts C; Schultze JL; Knolle PA; Klotz L. 2012. Lack of PPARgamma in myeloid cells confers resistance to Listeria monocytogenes infection. PLoS One 7(5):e37349. [PubMed: 22629382]  [MGI Ref ID J:196535]

Abromson-Leeman S; Bronson R; Luo Y; Berman M; Leeman R; Leeman J; Dorf M. 2004. T-cell properties determine disease site, clinical presentation, and cellular pathology of experimental autoimmune encephalomyelitis. Am J Pathol 165(5):1519-33. [PubMed: 15509523]  [MGI Ref ID J:109724]

Abromson-Leeman S; Ladell DS; Bronson RT; Dorf ME. 2007. Heterogeneity of EAE mediated by multiple distinct T-effector subsets. J Neuroimmunol 192(1-2):3-12. [PubMed: 17976744]  [MGI Ref ID J:128953]

Adams B; Nagy N; Paulart F; Vanderhaeghen ML; Goldman M; Flamand V. 2003. CD8+ T lymphocytes regulating Th2 pathology escape neonatal tolerization. J Immunol 171(10):5071-6. [PubMed: 14607904]  [MGI Ref ID J:117990]

Afanasyeva M; Georgakopoulos D; Belardi DF; Bedja D; Fairweather D; Wang Y; Kaya Z; Gabrielson KL; Rodriguez ER; Caturegli P; Kass DA; Rose NR. 2005. Impaired up-regulation of CD25 on CD4+ T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart failure. Proc Natl Acad Sci U S A 102(1):180-5. [PubMed: 15611472]  [MGI Ref ID J:95757]

Afshar-Sterle S; Zotos D; Bernard NJ; Scherger AK; Rodling L; Alsop AE; Walker J; Masson F; Belz GT; Corcoran LM; O'Reilly LA; Strasser A; Smyth MJ; Johnstone R; Tarlinton DM; Nutt SL; Kallies A. 2014. Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas. Nat Med 20(3):283-90. [PubMed: 24487434]  [MGI Ref ID J:208773]

Aguilar PV; Paessler S; Carrara AS; Baron S; Poast J; Wang E; Moncayo AC; Anishchenko M; Watts D; Tesh RB; Weaver SC. 2005. Variation in interferon sensitivity and induction among strains of eastern equine encephalitis virus. J Virol 79(17):11300-10. [PubMed: 16103182]  [MGI Ref ID J:101624]

Akhiani AA; Pappo J; Kabok Z; Schon K; Gao W; Franzen LE; Lycke N. 2002. Protection against Helicobacter pylori infection following immunization is IL-12-dependent and mediated by Th1 cells. J Immunol 169(12):6977-84. [PubMed: 12471132]  [MGI Ref ID J:118009]

Al Shamsi M; Shahin A; Iwakura Y; Lukic ML; Mensah-Brown EP. 2013. Pam3CSK(4) enhanced beta cell loss and diabetogenesis: the roles of IFN-gamma and IL-17. Clin Immunol 149(1):86-96. [PubMed: 23899994]  [MGI Ref ID J:202102]

Alayan J; Ivanovski S; Farah CS. 2007. Alveolar bone loss in T helper 1/T helper 2 cytokine-deficient mice. J Periodontal Res 42(2):97-103. [PubMed: 17305866]  [MGI Ref ID J:147935]

Alexander WS; Starr R; Fenner JE; Scott CL; Handman E; Sprigg NS; Corbin JE; Cornish AL; Darwiche R; Owczarek CM; Kay TW; Nicola NA; Hertzog PJ; Metcalf D; Hilton DJ. 1999. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98(5):597-608. [PubMed: 10490099]  [MGI Ref ID J:57474]

Aliberti JC; Souto JT; Marino AP; Lannes-Vieira J; Teixeira MM; Farber J; Gazzinelli RT; Silva JS. 2001. Modulation of chemokine production and inflammatory responses in interferon-gamma- and tumor necrosis factor-R1-deficient mice during Trypanosoma cruzi infection. Am J Pathol 158(4):1433-40. [PubMed: 11290561]  [MGI Ref ID J:68668]

Aly S; Laskay T; Mages J; Malzan A; Lang R; Ehlers S. 2007. Interferon-gamma-dependent mechanisms of mycobacteria-induced pulmonary immunopathology: the role of angiostasis and CXCR3-targeted chemokines for granuloma necrosis. J Pathol 212(3):295-305. [PubMed: 17534845]  [MGI Ref ID J:122272]

Amante FH; Haque A; Stanley AC; Rivera Fde L; Randall LM; Wilson YA; Yeo G; Pieper C; Crabb BS; de Koning-Ward TF; Lundie RJ; Good MF; Pinzon-Charry A; Pearson MS; Duke MG; McManus DP; Loukas A; Hill GR; Engwerda CR. 2010. Immune-Mediated Mechanisms of Parasite Tissue Sequestration during Experimental Cerebral Malaria. J Immunol 185(6):3632-42. [PubMed: 20720206]  [MGI Ref ID J:163540]

Ambati BK; Nozaki M; Singh N; Takeda A; Jani PD; Suthar T; Albuquerque RJ; Richter E; Sakurai E; Newcomb MT; Kleinman ME; Caldwell RB; Lin Q; Ogura Y; Orecchia A; Samuelson DA; Agnew DW; St Leger J; Green WR; Mahasreshti PJ; Curiel DT; Kwan D; Marsh H; Ikeda S; Leiper LJ; Collinson JM; Bogdanovich S; Khurana TS; Shibuya M; Baldwin ME; Ferrara N; Gerber HP; De Falco S; Witta J; Baffi JZ; Raisler BJ; Ambati J. 2006. Corneal avascularity is due to soluble VEGF receptor-1. Nature 443(7114):993-7. [PubMed: 17051153]  [MGI Ref ID J:114973]

Amiri P; Haak-Frendscho M; Robbins K; McKerrow JH; Stewart T; Jardieu P. 1994. Anti-immunoglobulin E treatment decreases worm burden and egg production in Schistosoma mansoni-infected normal and interferon gamma knockout mice. J Exp Med 180(1):43-51. [PubMed: 8006599]  [MGI Ref ID J:18740]

Andersen C; Jensen T; Nansen A; Marker O; Thomsen AR. 1999. CD4(+) T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-gamma or IL-4. Int Immunol 11(12):2035-42. [PubMed: 10590269]  [MGI Ref ID J:110491]

Andoh A; Masuda A; Kumazawa Y; Kasajima T. 2002. Serum antibody response and nasal lymphoid tissue (NALT) structure in the absence of IL-4 or IFN-gamma. Cytokine 20(3):107-12. [PubMed: 12453468]  [MGI Ref ID J:102594]

Andoh A; Masuda A; Yamakawa M; Kumazawa Y; Kasajima T. 2000. Absence of interleukin-4 enhances germinal center reaction in secondary immune response. Immunol Lett 73(1):35-41. [PubMed: 10963809]  [MGI Ref ID J:110473]

Andoh M; Zhang G; Russell-Lodrigue KE; Shive HR; Weeks BR; Samuel JE. 2007. T Cells Are Essential for Bacterial Clearance, and Gamma Interferon, Tumor Necrosis Factor Alpha, and B Cells Are Crucial for Disease Development in Coxiella burnetii Infection in Mice. Infect Immun 75(7):3245-55. [PubMed: 17438029]  [MGI Ref ID J:122426]

Andrade RM; Portillo JA; Wessendarp M; Subauste CS. 2005. CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates. Infect Immun 73(5):3115-23. [PubMed: 15845519]  [MGI Ref ID J:97614]

Andreasen SO; Christensen JE; Marker O; Thomsen AR. 2000. Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8+ effector T cell responses. J Immunol 164(7):3689-97. [PubMed: 10725727]  [MGI Ref ID J:123023]

Anthony DA; Andrews DM; Chow M; Watt SV; House C; Akira S; Bird PI; Trapani JA; Smyth MJ. 2010. A role for granzyme M in TLR4-driven inflammation and endotoxicosis. J Immunol 185(3):1794-803. [PubMed: 20585036]  [MGI Ref ID J:162467]

Apte SH; Groves P; Olver S; Baz A; Doolan DL; Kelso A; Kienzle N. 2010. IFN-gamma inhibits IL-4-induced type 2 cytokine expression by CD8 T cells in vivo and modulates the anti-tumor response. J Immunol 185(2):998-1004. [PubMed: 20562261]  [MGI Ref ID J:161926]

Arantes RM; Marche HH; Bahia MT; Cunha FQ; Rossi MA; Silva JS. 2004. Interferon-gamma-induced nitric oxide causes intrinsic intestinal denervation in Trypanosoma cruzi-infected mice. Am J Pathol 164(4):1361-8. [PubMed: 15039223]  [MGI Ref ID J:89108]

Arens R; Baars PA; Jak M; Tesselaar K; van der Valk M; van Oers MH; van Lier RA. 2005. Cutting edge: CD95 maintains effector T cell homeostasis in chronic immune activation. J Immunol 174(10):5915-20. [PubMed: 15879081]  [MGI Ref ID J:98994]

Arens R; Nolte MA; Tesselaar K; Heemskerk B; Reedquist KA; van Lier RA; van Oers MH. 2004. Signaling through CD70 regulates B cell activation and IgG production. J Immunol 173(6):3901-8. [PubMed: 15356138]  [MGI Ref ID J:92744]

Arora S; Hernandez Y; Erb-Downward JR; McDonald RA; Toews GB; Huffnagle GB. 2005. Role of IFN-gamma in regulating T2 immunity and the development of alternatively activated macrophages during allergic bronchopulmonary mycosis. J Immunol 174(10):6346-56. [PubMed: 15879135]  [MGI Ref ID J:99045]

Arora S; Olszewski MA; Tsang TM; McDonald RA; Toews GB; Huffnagle GB. 2011. Effect of Cytokine Interplay on Macrophage Polarization during Chronic Pulmonary Infection with Cryptococcus neoformans. Infect Immun 79(5):1915-26. [PubMed: 21383052]  [MGI Ref ID J:171937]

Arsenijevic D; Clavel S; Sanchis D; Plamondon J; Huang Q; Ricquier D; Rouger L; Richard D. 2007. Induction of Ucp2 expression in brain phagocytes and neurons following murine toxoplasmosis: an essential role of IFN-gamma and an association with negative energy balance. J Neuroimmunol 186(1-2):121-32. [PubMed: 17467814]  [MGI Ref ID J:124552]

Artis D; Villarino A; Silverman M; He W; Thornton EM; Mu S; Summer S; Covey TM; Huang E; Yoshida H; Koretzky G; Goldschmidt M; Wu GD; de Sauvage F; Miller HR; Saris CJ; Scott P; Hunter CA. 2004. The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. J Immunol 173(9):5626-34. [PubMed: 15494513]  [MGI Ref ID J:93739]

Ashkar AA; Croy BA. 1999. Interferon-gamma contributes to the normalcy of murine pregnancy. Biol Reprod 61(2):493-502. [PubMed: 10411532]  [MGI Ref ID J:56503]

Ashkar AA; Di Santo JP; Croy BA. 2000. Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy [see comments] J Exp Med 192(2):259-70. [PubMed: 10899912]  [MGI Ref ID J:63645]

Awoniyi M; Miller SI; Wilson CB; Hajjar AM; Smith KD. 2012. Homeostatic regulation of Salmonella-induced mucosal inflammation and injury by IL-23. PLoS One 7(5):e37311. [PubMed: 22624013]  [MGI Ref ID J:187224]

Badovinac VP; Harty JT. 2000. Adaptive immunity and enhanced CD8+ T cell response to Listeria monocytogenes in the absence of perforin and IFN-gamma. J Immunol 164(12):6444-52. [PubMed: 10843700]  [MGI Ref ID J:83175]

Badovinac VP; Tvinnereim AR; Harty JT. 2000. Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma. Science 290(5495):1354-8. [PubMed: 11082062]  [MGI Ref ID J:83176]

Bai Y; Liu R; Huang D; La Cava A; Tang YY; Iwakura Y; Campagnolo DI; Vollmer TL; Ransohoff RM; Shi FD. 2008. CCL2 recruitment of IL-6-producing CD11b(+) monocytes to the draining lymph nodes during the initiation of Th17-dependent B cell-mediated autoimmunity. Eur J Immunol 38(7):1877-88. [PubMed: 18581322]  [MGI Ref ID J:137386]

Baird JR; Byrne KT; Lizotte PH; Toraya-Brown S; Scarlett UK; Alexander MP; Sheen MR; Fox BA; Bzik DJ; Bosenberg M; Mullins DW; Turk MJ; Fiering S. 2013. Immune-Mediated Regression of Established B16F10 Melanoma by Intratumoral Injection of Attenuated Toxoplasma gondii Protects against Rechallenge. J Immunol 190(1):469-78. [PubMed: 23225891]  [MGI Ref ID J:190812]

Baldeviano GC; Barin JG; Talor MV; Srinivasan S; Bedja D; Zheng D; Gabrielson K; Iwakura Y; Rose NR; Cihakova D. 2010. Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy. Circ Res 106(10):1646-55. [PubMed: 20378858]  [MGI Ref ID J:172627]

Baldridge MT; King KY; Boles NC; Weksberg DC; Goodell MA. 2010. Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature 465(7299):793-7. [PubMed: 20535209]  [MGI Ref ID J:161947]

Balish E; Wagner RD; Vazquez-Torres A; Pierson C; Warner T. 1998. Candidiasis in interferon-gamma knockout (IFN-gamma-/-) mice. J Infect Dis 178(2):478-87. [PubMed: 9697730]  [MGI Ref ID J:120514]

Ballas ZK; Buchta CM; Rosean TR; Heusel JW; Shey MR. 2013. Role of NK cell subsets in organ-specific murine melanoma metastasis. PLoS One 8(6):e65599. [PubMed: 23776508]  [MGI Ref ID J:204234]

Balomenos D; Rumold R; Theofilopoulos AN. 1998. Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J Clin Invest 101(2):364-71. [PubMed: 9435308]  [MGI Ref ID J:45391]

Bao S; Beagley KW; France MP; Shen J; Husband AJ. 2000. Interferon-gamma plays a critical role in intestinal immunity against Salmonella typhimurium infection. Immunology 99(3):464-72. [PubMed: 10712678]  [MGI Ref ID J:61050]

Barber EM; Fazzari M; Pollard JW. 2005. Th1 cytokines are essential for placental immunity to Listeria monocytogenes. Infect Immun 73(10):6322-31. [PubMed: 16177303]  [MGI Ref ID J:104232]

Barr TA; Brown S; Mastroeni P; Gray D. 2009. B cell intrinsic MyD88 signals drive IFN-gamma production from T cells and control switching to IgG2c. J Immunol 183(2):1005-12. [PubMed: 19542370]  [MGI Ref ID J:151505]

Barr TA; Brown S; Mastroeni P; Gray D. 2010. TLR and B cell receptor signals to B cells differentially program primary and memory Th1 responses to Salmonella enterica. J Immunol 185(5):2783-9. [PubMed: 20675594]  [MGI Ref ID J:163256]

Bartholdy C; Nansen A; Christensen JE; Marker O; Thomsen AR. 1999. Inducible nitric-oxide synthase plays a minimal role in lymphocytic choriomeningitis virus-induced, T cell-mediated protective immunity and immunopathology. J Gen Virol 80(Pt 11):2997-3005. [PubMed: 10580062]  [MGI Ref ID J:103345]

Baschant U; Frappart L; Rauchhaus U; Bruns L; Reichardt HM; Kamradt T; Brauer R; Tuckermann JP. 2011. Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells. Proc Natl Acad Sci U S A 108(48):19317-22. [PubMed: 22084093]  [MGI Ref ID J:180395]

Bastos KR; de Deus Vieira de Moraes L; Zago CA; Marinho CR; Russo M; Alvarez JM; D'Imperio Lima MR. 2005. Analysis of the activation profile of dendritic cells derived from the bone marrow of interleukin-12/interleukin-23-deficient mice. Immunology 114(4):499-506. [PubMed: 15804287]  [MGI Ref ID J:97435]

Basu R; O'Quinn DB; Silberger DJ; Schoeb TR; Fouser L; Ouyang W; Hatton RD; Weaver CT. 2012. Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic Bacteria. Immunity 37(6):1061-75. [PubMed: 23200827]  [MGI Ref ID J:191059]

Batchelder JM; Burns JM Jr; Cigel FK; Lieberg H; Manning DD; Pepper BJ; Yanez DM; van der Heyde H; Weidanz WP. 2003. Plasmodium chabaudi adami: interferon-gamma but not IL-2 is essential for the expression of cell-mediated immunity against blood-stage parasites in mice. Exp Parasitol 105(2):159-66. [PubMed: 14969693]  [MGI Ref ID J:102606]

Beattie L; Svensson M; Bune A; Brown N; Maroof A; Zubairi S; Smith KR; Kaye PM. 2010. Leishmania donovani-induced expression of signal regulatory protein alpha on Kupffer cells enhances hepatic invariant NKT-cell activation. Eur J Immunol 40(1):117-23. [PubMed: 19877019]  [MGI Ref ID J:155693]

Behrens EM; Canna SW; Slade K; Rao S; Kreiger PA; Paessler M; Kambayashi T; Koretzky GA. 2011. Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice. J Clin Invest 121(6):2264-77. [PubMed: 21576823]  [MGI Ref ID J:173903]

Bendle GM; Linnemann C; Hooijkaas AI; Bies L; de Witte MA; Jorritsma A; Kaiser AD; Pouw N; Debets R; Kieback E; Uckert W; Song JY; Haanen JB; Schumacher TN. 2010. Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy. Nat Med 16(5):565-70, 1p following 570. [PubMed: 20400962]  [MGI Ref ID J:160623]

Bergmann CC; Parra B; Hinton DR; Chandran R; Morrison M; Stohlman SA. 2003. Perforin-mediated effector function within the central nervous system requires IFN-gamma-mediated MHC up-regulation. J Immunol 170(6):3204-13. [PubMed: 12626579]  [MGI Ref ID J:126219]

Berner V; Liu H; Zhou Q; Alderson KL; Sun K; Weiss JM; Back TC; Longo DL; Blazar BR; Wiltrout RH; Welniak LA; Redelman D; Murphy WJ. 2007. IFN-gamma mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy. Nat Med 13(3):354-60. [PubMed: 17334371]  [MGI Ref ID J:121706]

Betts G; Twohig J; Van den Broek M; Sierro S; Godkin A; Gallimore A. 2007. The impact of regulatory T cells on carcinogen-induced sarcogenesis. Br J Cancer 96(12):1849-54. [PubMed: 17565340]  [MGI Ref ID J:122744]

Bi Y; Zhou J; Yang H; Wang X; Zhang X; Wang Q; Wu X; Han Y; Song Y; Tan Y; Du Z; Yang H; Zhou D; Cui Y; Zhou L; Yan Y; Zhang P; Guo Z; Wang X; Liu G; Yang R. 2014. IL-17A produced by neutrophils protects against pneumonic plague through orchestrating IFN-gamma-activated macrophage programming. J Immunol 192(2):704-13. [PubMed: 24337746]  [MGI Ref ID J:207323]

Birkner K; Steiner B; Rinkler C; Kern Y; Aichele P; Bogdan C; von Loewenich FD. 2008. The elimination of Anaplasma phagocytophilum requires CD4(+) T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms. Eur J Immunol 38(12):3395-3410. [PubMed: 19039769]  [MGI Ref ID J:141369]

Bishop DK; Chan Wood S; Eichwald EJ; Orosz CG. 2001. Immunobiology of allograft rejection in the absence of IFN-gamma: CD8+ effector cells develop independently of CD4+ cells and CD40-CD40 ligand interactions. J Immunol 166(5):3248-55. [PubMed: 11207279]  [MGI Ref ID J:126479]

Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. [PubMed: 15153508]  [MGI Ref ID J:90518]

Bitsaktsis C; Nandi B; Racine R; MacNamara KC; Winslow G. 2007. T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection. Infect Immun 75(10):4933-41. [PubMed: 17664264]  [MGI Ref ID J:125283]

Bitsaktsis C; Rawool DB; Li Y; Kurkure NV; Iglesias B; Gosselin EJ. 2009. Differential requirements for protection against mucosal challenge with Francisella tularensis in the presence versus absence of cholera toxin B and inactivated F. tularensis. J Immunol 182(8):4899-909. [PubMed: 19342669]  [MGI Ref ID J:147502]

Blais ME; Brochu S; Giroux M; Belanger MP; Dulude G; Sekaly RP; Perreault C. 2008. Why T cells of thymic versus extrathymic origin are functionally different. J Immunol 180(4):2299-312. [PubMed: 18250439]  [MGI Ref ID J:131997]

Blazar BR; Carreno BM; Panoskaltsis-Mortari A; Carter L; Iwai Y; Yagita H; Nishimura H; Taylor PA. 2003. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J Immunol 171(3):1272-7. [PubMed: 12874215]  [MGI Ref ID J:120213]

Blazar BR; Lees CJ; Martin PJ; Noelle RJ; Kwon B; Murphy W; Taylor PA. 2000. Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions. J Immunol 165(9):4901-9. [PubMed: 11046015]  [MGI Ref ID J:118027]

Blohm U; Potthoff D; van der Kogel AJ; Pircher H. 2006. Solid tumors 'melt' from the inside after successful CD8 T cell attack. Eur J Immunol 36(2):468-77. [PubMed: 16385625]  [MGI Ref ID J:113858]

Bokhari SM; Kim KJ; Pinson DM; Slusser J; Yeh HW; Parmely MJ. 2008. NK cells and gamma interferon coordinate the formation and function of hepatic granulomas in mice infected with the Francisella tularensis live vaccine strain. Infect Immun 76(4):1379-89. [PubMed: 18227174]  [MGI Ref ID J:133531]

Borjesson DL; Simon SI; Hodzic E; Ballantyne CM; Barthold SW. 2002. Kinetics of CD11b/CD18 up-regulation during infection with the agent of human granulocytic ehrlichiosis in mice. Lab Invest 82(3):303-11. [PubMed: 11896209]  [MGI Ref ID J:75433]

Bouley DM; Kanangat S; Wire W; Rouse BT. 1995. Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-gamma knockout mice. J Immunol 155(8):3964-71. [PubMed: 7561104]  [MGI Ref ID J:29170]

Bour-Jordan H; Thompson HL; Bluestone JA. 2005. Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice. J Immunol 175(9):5649-55. [PubMed: 16237054]  [MGI Ref ID J:119359]

Brandl K; Plitas G; Schnabl B; DeMatteo RP; Pamer EG. 2007. MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. J Exp Med 204(8):1891-900. [PubMed: 17635956]  [MGI Ref ID J:125955]

Bregenholt S; Berche P; Brombacher F; Di Santo JP. 2001. Conventional alpha beta T cells are sufficient for innate and adaptive immunity against enteric Listeria monocytogenes. J Immunol 166(3):1871-6. [PubMed: 11160234]  [MGI Ref ID J:127008]

Breser ML; Motrich RD; Sanchez LR; Mackern-Oberti JP; Rivero VE. 2013. Expression of CXCR3 on Specific T Cells Is Essential for Homing to the Prostate Gland in an Experimental Model of Chronic Prostatitis/Chronic Pelvic Pain Syndrome. J Immunol 190(7):3121-33. [PubMed: 23455510]  [MGI Ref ID J:194822]

Brien JD; Uhrlaub JL; Hirsch A; Wiley CA; Nikolich-Zugich J. 2009. Key role of T cell defects in age-related vulnerability to West Nile virus. J Exp Med 206(12):2735-45. [PubMed: 19901080]  [MGI Ref ID J:155455]

Briesemeister D; Friese C; Isern CC; Dietz E; Blankenstein T; Thoene-Reineke C; Kammertoens T. 2012. Differences in serum cytokine levels between wild type mice and mice with a targeted mutation suggests necessity of using control littermates. Cytokine 60(3):626-33. [PubMed: 22902947]  [MGI Ref ID J:192770]

Brochard V; Combadiere B; Prigent A; Laouar Y; Perrin A; Beray-Berthat V; Bonduelle O; Alvarez-Fischer D; Callebert J; Launay JM; Duyckaerts C; Flavell RA; Hirsch EC; Hunot S. 2009. Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest 119(1):182-92. [PubMed: 19104149]  [MGI Ref ID J:144702]

Brown DM; Dilzer AM; Meents DL; Swain SL. 2006. CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch. J Immunol 177(5):2888-98. [PubMed: 16920924]  [MGI Ref ID J:139502]

Bry L; Brigl M; Brenner MB. 2006. CD4+-T-cell effector functions and costimulatory requirements essential for surviving mucosal infection with Citrobacter rodentium. Infect Immun 74(1):673-81. [PubMed: 16369024]  [MGI Ref ID J:104251]

Buchanan RM; Arulanandam BP; Metzger DW. 1998. IL-12 enhances antibody responses to T-independent polysaccharide vaccines in the absence of T and NK cells. J Immunol 161(10):5525-33. [PubMed: 9820529]  [MGI Ref ID J:115023]

Buhtoiarov IN; Lum HD; Berke G; Sondel PM; Rakhmilevich AL. 2006. Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects. J Immunol 176(1):309-18. [PubMed: 16365423]  [MGI Ref ID J:126263]

Buhtoiarov IN; Sondel PM; Eickhoff JC; Rakhmilevich AL. 2007. Macrophages are essential for antitumour effects against weakly immunogenic murine tumours induced by class B CpG-oligodeoxynucleotides. Immunology 120(3):412-23. [PubMed: 17163960]  [MGI Ref ID J:122619]

Bullen DV; Baldwin TM; Curtis JM; Alexander WS; Handman E. 2003. Persistence of lesions in suppressor of cytokine signaling-1-deficient mice infected with Leishmania major. J Immunol 170(8):4267-72. [PubMed: 12682261]  [MGI Ref ID J:125437]

Bullen DV; Darwiche R; Metcalf D; Handman E; Alexander WS. 2001. Neutralization of interferon-gamma in neonatal SOCS1-/- mice prevents fatty degeneration of the liver but not subsequent fatal inflammatory disease. Immunology 104(1):92-8. [PubMed: 11576226]  [MGI Ref ID J:71691]

Buono C; Come CE; Stavrakis G; Maguire GF; Connelly PW; Lichtman AH. 2003. Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouse. Arterioscler Thromb Vasc Biol 23(3):454-60. [PubMed: 12615659]  [MGI Ref ID J:103072]

Burch LH; Yang IV; Whitehead GS; Chao FG; Berman KG; Schwartz DA. 2006. The transcriptional response to lipopolysaccharide reveals a role for interferon-gamma in lung neutrophil recruitment. Am J Physiol Lung Cell Mol Physiol 291(4):L677-82. [PubMed: 16766576]  [MGI Ref ID J:144404]

Burdeinick-Kerr R; Wind J; Griffin DE. 2007. Synergistic roles of antibody and interferon in noncytolytic clearance of Sindbis virus from different regions of the central nervous system. J Virol 81(11):5628-36. [PubMed: 17376910]  [MGI Ref ID J:153321]

Burman AC; Banovic T; Kuns RD; Clouston AD; Stanley AC; Morris ES; Rowe V; Bofinger H; Skoczylas R; Raffelt N; Fahy O; McColl SR; Engwerda CR; McDonald KP; Hill GR. 2007. IFNgamma differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract. Blood 110(3):1064-72. [PubMed: 17449800]  [MGI Ref ID J:145394]

Burne MJ; Daniels F; El Ghandour A; Mauiyyedi S; Colvin RB; O'Donnell MP; Rabb H. 2001. Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure. J Clin Invest 108(9):1283-90. [PubMed: 11696572]  [MGI Ref ID J:118005]

Burrell BE; Csencsits K; Lu G; Grabauskiene S; Bishop DK. 2008. CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice. J Immunol 181(6):3906-14. [PubMed: 18768845]  [MGI Ref ID J:139106]

Buxbaum LU; Uzonna JE; Goldschmidt MH; Scott P. 2002. Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent. Eur J Immunol 32(11):3206-15. [PubMed: 12555666]  [MGI Ref ID J:115538]

Caccamo N; Sireci G; Meraviglia S; Dieli F; Ivanyi J; Salerno A. 2006. gammadelta T cells condition dendritic cells in vivo for priming pulmonary CD8 T cell responses against Mycobacterium tuberculosis. Eur J Immunol 36(10):2681-90. [PubMed: 16981183]  [MGI Ref ID J:118094]

Cafruny WA; Bradley SE; Rowland RR. 1999. Regulation of immune complexes during infection of mice with lactate dehydrogenase-elevating virus: studies with interferon-gamma gene knockout and tolerant mice. Viral Immunol 12(2):163-73. [PubMed: 10413362]  [MGI Ref ID J:58076]

Cain JA; Smith JA; Ondr JK; Wang B; Katz JD. 2006. NKT cells and IFN-gamma establish the regulatory environment for the control of diabetogenic T cells in the nonobese diabetic mouse. J Immunol 176(3):1645-54. [PubMed: 16424194]  [MGI Ref ID J:126603]

Calabrese V; Mallette FA; Deschenes-Simard X; Ramanathan S; Gagnon J; Moores A; Ilangumaran S; Ferbeyre G. 2009. SOCS1 links cytokine signaling to p53 and senescence. Mol Cell 36(5):754-67. [PubMed: 20005840]  [MGI Ref ID J:155447]

Campos MA; Closel M; Valente EP; Cardoso JE; Akira S; Alvarez-Leite JI; Ropert C; Gazzinelli RT. 2004. Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88. J Immunol 172(3):1711-8. [PubMed: 14734753]  [MGI Ref ID J:87693]

Campos RA; Szczepanik M; Itakura A; Akahira-Azuma M; Sidobre S; Kronenberg M; Askenase PW. 2003. Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity. J Exp Med 198(12):1785-96. [PubMed: 14676294]  [MGI Ref ID J:132827]

Cannons JL; Yu LJ; Hill B; Mijares LA; Dombroski D; Nichols KE; Antonellis A; Koretzky GA; Gardner K; Schwartzberg PL. 2004. SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1. Immunity 21(5):693-706. [PubMed: 15539155]  [MGI Ref ID J:93887]

Cantin E; Tanamachi B; Openshaw H; Mann J; Clarke K. 1999. Gamma interferon (IFN-gamma) receptor null-mutant mice are more susceptible to herpes simplex virus type 1 infection than IFN-gamma ligand null-mutant mice. J Virol 73(6):5196-200. [PubMed: 10233988]  [MGI Ref ID J:54949]

Cao W; Yang Y; Wang Z; Liu A; Fang L; Wu F; Hong J; Shi Y; Leung S; Dong C; Zhang JZ. 2011. Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease. Immunity 35(2):273-84. [PubMed: 21835648]  [MGI Ref ID J:176067]

Cao X; Leonard K; Collins LI; Cai SF; Mayer JC; Payton JE; Walter MJ; Piwnica-Worms D; Schreiber RD; Ley TJ. 2009. Interleukin 12 stimulates IFN-gamma-mediated inhibition of tumor-induced regulatory T-cell proliferation and enhances tumor clearance. Cancer Res 69(22):8700-9. [PubMed: 19843867]  [MGI Ref ID J:154453]

Caretto D; Katzman SD; Villarino AV; Gallo E; Abbas AK. 2010. Cutting edge: the Th1 response inhibits the generation of peripheral regulatory T cells. J Immunol 184(1):30-4. [PubMed: 19949064]  [MGI Ref ID J:159046]

Carow B; Ye X; Gavier-Widen D; Bhuju S; Oehlmann W; Singh M; Skold M; Ignatowicz L; Yoshimura A; Wigzell H; Rottenberg ME. 2011. Silencing suppressor of cytokine signaling-1 (SOCS1) in macrophages improves Mycobacterium tuberculosis control in an interferon-gamma (IFN-gamma)-dependent manner. J Biol Chem 286(30):26873-87. [PubMed: 21622562]  [MGI Ref ID J:175389]

Carvalho-Pinto CE; Garcia MI; Mellado M; Rodriguez-Frade JM; Martin-Caballero J; Flores J; Martinez-A C; Balomenos D. 2002. Autocrine production of IFN-gamma by macrophages controls their recruitment to kidney and the development of glomerulonephritis in MRL/lpr mice. J Immunol 169(2):1058-67. [PubMed: 12097414]  [MGI Ref ID J:123834]

Case LK; Petell L; Yurkovetskiy L; Purdy A; Savage KJ; Golovkina TV. 2008. Replication of beta- and gammaretroviruses is restricted in I/LnJ mice via the same genetic mechanism. J Virol 82(3):1438-47. [PubMed: 18057254]  [MGI Ref ID J:163153]

Castilow EM; Legge KL; Varga SM. 2008. Cutting edge: Eosinophils do not contribute to respiratory syncytial virus vaccine-enhanced disease. J Immunol 181(10):6692-6. [PubMed: 18981084]  [MGI Ref ID J:140954]

Cathcart HM; Zheng M; Covar JJ; Liu Y; Podolsky R; Atherton SS. 2011. Interferon-gamma, macrophages, and virus spread after HSV-1 injection. Invest Ophthalmol Vis Sci 52(7):3984-93. [PubMed: 21345992]  [MGI Ref ID J:181441]

Cenci E; Mencacci A; Del Sero G; Bacci A; Montagnoli C; d'Ostiani CF; Mosci P; Bachmann M; Bistoni F; Kopf M; Romani L. 1999. Interleukin-4 causes susceptibility to invasive pulmonary aspergillosis through suppression of protective type I responses. J Infect Dis 180(6):1957-68. [PubMed: 10558953]  [MGI Ref ID J:119841]

Cernetich A; Garver LS; Jedlicka AE; Klein PW; Kumar N; Scott AL; Klein SL. 2006. Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection. Infect Immun 74(6):3190-203. [PubMed: 16714546]  [MGI Ref ID J:109239]

Chan CJ; Andrews DM; McLaughlin NM; Yagita H; Gilfillan S; Colonna M; Smyth MJ. 2010. DNAM-1/CD155 interactions promote cytokine and NK cell-mediated suppression of poorly immunogenic melanoma metastases. J Immunol 184(2):902-11. [PubMed: 20008292]  [MGI Ref ID J:159408]

Chan WC; Duong TT; Yeung RS. 2004. Presence of IFN-gamma does not indicate its necessity for induction of coronary arteritis in an animal model of Kawasaki disease. J Immunol 173(5):3492-503. [PubMed: 15322214]  [MGI Ref ID J:92708]

Chang CP; Yang MC; Lei HY. 2011. Concanavalin A/IFN-gamma triggers autophagy-related necrotic hepatocyte death through IRGM1-mediated lysosomal membrane disruption. PLoS One 6(12):e28323. [PubMed: 22163006]  [MGI Ref ID J:182269]

Chang JH; Cha HR; Chang SY; Ko HJ; Seo SU; Kweon MN. 2011. IFN-gamma secreted by CD103+ dendritic cells leads to IgG generation in the mesenteric lymph node in the absence of vitamin A. J Immunol 186(12):6999-7005. [PubMed: 21572021]  [MGI Ref ID J:175489]

Chang JT; Shevach EM; Segal BM. 1999. Regulation of interleukin (IL)-12 receptor beta2 subunit expression by endogenous IL-12: a critical step in the differentiation of pathogenic autoreactive T cells. J Exp Med 189(6):969-78. [PubMed: 10075980]  [MGI Ref ID J:53619]

Chang YJ; Kim HY; Albacker LA; Baumgarth N; McKenzie AN; Smith DE; Dekruyff RH; Umetsu DT. 2011. Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. Nat Immunol 12(7):631-8. [PubMed: 21623379]  [MGI Ref ID J:174316]

Charles E; Joshi S; Ash JD; Fox BA; Farris AD; Bzik DJ; Lang ML; Blader IJ. 2010. CD4 T-cell suppression by cells from Toxoplasma gondii-infected retinas is mediated by surface protein PD-L1. Infect Immun 78(8):3484-92. [PubMed: 20498261]  [MGI Ref ID J:161696]

Chatterjee S; Eby JM; Al-Khami AA; Soloshchenko M; Kang HK; Kaur N; Naga OS; Murali A; Nishimura MI; Le Poole IC; Mehrotra S. 2014. A quantitative increase in regulatory T cells controls development of vitiligo. J Invest Dermatol 134(5):1285-94. [PubMed: 24366614]  [MGI Ref ID J:208054]

Chen ES; Greenlee BM; Wills-Karp M; Moller DR. 2001. Attenuation of lung inflammation and fibrosis in interferon-gamma-deficient mice after intratracheal bleomycin. Am J Respir Cell Mol Biol 24(5):545-55. [PubMed: 11350823]  [MGI Ref ID J:114439]

Chen K; McAleer JP; Lin Y; Paterson DL; Zheng M; Alcorn JF; Weaver CT; Kolls JK. 2011. Th17 cells mediate clade-specific, serotype-independent mucosal immunity. Immunity 35(6):997-1009. [PubMed: 22195749]  [MGI Ref ID J:179276]

Chen K; Wei Y; Sharp GC; Braley-Mullen H. 2003. Mechanisms of spontaneous resolution versus fibrosis in granulomatous experimental autoimmune thyroiditis. J Immunol 171(11):6236-43. [PubMed: 14634140]  [MGI Ref ID J:117995]

Chen ML; Yan BS; Kozoriz D; Weiner HL. 2009. Novel CD8+ Treg suppress EAE by TGF-beta- and IFN-gamma-dependent mechanisms. Eur J Immunol 39(12):3423-35. [PubMed: 19768696]  [MGI Ref ID J:155492]

Chen Y; Chong MM; Darwiche R; Thomas HE; Kay TW. 2004. Severe pancreatitis with exocrine destruction and increased islet neogenesis in mice with suppressor of cytokine signaling-1 deficiency. Am J Pathol 165(3):913-21. [PubMed: 15331415]  [MGI Ref ID J:92419]

Cheng M; Nguyen MH; Fantuzzi G; Koh TJ. 2008. Endogenous interferon-gamma is required for efficient skeletal muscle regeneration. Am J Physiol Cell Physiol 294(5):C1183-91. [PubMed: 18353892]  [MGI Ref ID J:136628]

Chensue SW; Warmington K; Ruth JH; Lukacs N; Kunkel SL. 1997. Mycobacterial and schistosomal antigen-elicited granuloma formation in IFN-gamma and IL-4 knockout mice: analysis of local and regional cytokine and chemokine networks. J Immunol 159(7):3565-73. [PubMed: 9317156]  [MGI Ref ID J:43085]

Chessler AD; Unnikrishnan M; Bei AK; Daily JP; Burleigh BA. 2009. Trypanosoma cruzi triggers an early type I IFN response in vivo at the site of intradermal infection. J Immunol 182(4):2288-96. [PubMed: 19201883]  [MGI Ref ID J:144788]

Chiaramonte MG; Hesse M; Cheever AW; Wynn TA. 2000. CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism. J Immunol 164(2):973-85. [PubMed: 10623847]  [MGI Ref ID J:127058]

Chiarle R; Martinengo C; Mastini C; Ambrogio C; D'Escamard V; Forni G; Inghirami G. 2008. The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination. Nat Med 14(6):676-80. [PubMed: 18469826]  [MGI Ref ID J:136968]

Chinen T; Kobayashi T; Ogata H; Takaesu G; Takaki H; Hashimoto M; Yagita H; Nawata H; Yoshimura A. 2006. Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved. Gastroenterology 130(2):373-88. [PubMed: 16472593]  [MGI Ref ID J:124924]

Chiodoni C; Stoppacciaro A; Sangaletti S; Gri G; Cappetti B; Koezuka Y; Colombo MP. 2001. Different requirements for alpha-galactosylceramide and recombinant IL-12 antitumor activity in the treatment of C-26 colon carcinoma hepatic metastases. Eur J Immunol 31(10):3101-10. [PubMed: 11592087]  [MGI Ref ID J:115631]

Cho HI; Celis E. 2009. Optimized peptide vaccines eliciting extensive CD8 T-cell responses with therapeutic antitumor effects. Cancer Res 69(23):9012-9. [PubMed: 19903852]  [MGI Ref ID J:155054]

Cho HI; Lee YR; Celis E. 2011. Interferon gamma limits the effectiveness of melanoma peptide vaccines. Blood 117(1):135-44. [PubMed: 20889921]  [MGI Ref ID J:168428]

Choi BK; Kim YH; Kim CH; Kim MS; Kim KH; Oh HS; Lee MJ; Lee DK; Vinay DS; Kwon BS. 2010. Peripheral 4-1BB signaling negatively regulates NK cell development through IFN-gamma. J Immunol 185(3):1404-11. [PubMed: 20610645]  [MGI Ref ID J:162245]

Choi KS; Song EK; Yim CY. 2008. Cytokines secreted by IL-2-activated lymphocytes induce endogenous nitric oxide synthesis and apoptosis in macrophages. J Leukoc Biol 83(6):1440-50. [PubMed: 18339892]  [MGI Ref ID J:136847]

Chong SZ; Tan KW; Wong FH; Chua YL; Tang Y; Ng LG; Angeli V; Kemeny DM. 2014. CD8 T Cells Regulate Allergic Contact Dermatitis by Modulating CCR2-Dependent TNF/iNOS-Expressing Ly6C(+)CD11b(+) Monocytic Cells. J Invest Dermatol 134(3):666-76. [PubMed: 24061165]  [MGI Ref ID J:206039]

Choudhury A; Cohen PL; Eisenberg RA. 2010. B cells require 'nurturing' by CD4 T cells during development in order to respond in chronic graft-versus-host model of systemic lupus erythematosus. Clin Immunol :. [PubMed: 20381429]  [MGI Ref ID J:160847]

Christensen JE; Simonsen S; Fenger C; Sorensen MR; Moos T; Christensen JP; Finsen B; Thomsen AR. 2009. Fulminant lymphocytic choriomeningitis virus-induced inflammation of the CNS involves a cytokine-chemokine-cytokine-chemokine cascade. J Immunol 182(2):1079-87. [PubMed: 19124751]  [MGI Ref ID J:143550]

Christensen JE; Wodarz D; Christensen JP; Thomsen AR. 2004. Perforin and IFN-gamma do not significantly regulate the virus-specific CD8+ T cell response in the absence of antiviral effector activity. Eur J Immunol 34(5):1389-94. [PubMed: 15114672]  [MGI Ref ID J:89390]

Christensen JP; Bartholdy C; Wodarz D; Thomsen AR. 2001. Depletion of CD4+ T cells precipitates immunopathology in immunodeficient mice infected with a noncytocidal virus. J Immunol 166(5):3384-91. [PubMed: 11207295]  [MGI Ref ID J:126477]

Chu CQ; Song Z; Mayton L; Wu B; Wooley PH. 2003. IFNgamma deficient C57BL/6 (H-2b) mice develop collagen induced arthritis with predominant usage of T cell receptor Vbeta6 and Vbeta8 in arthritic joints. Ann Rheum Dis 62(10):983-90. [PubMed: 12972478]  [MGI Ref ID J:106216]

Chu CQ; Wittmer S; Dalton DK. 2000. Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis J Exp Med 192(1):123-8. [PubMed: 10880533]  [MGI Ref ID J:63143]

Ciric B; El-behi M; Cabrera R; Zhang GX; Rostami A. 2009. IL-23 drives pathogenic IL-17-producing CD8+ T cells. J Immunol 182(9):5296-305. [PubMed: 19380776]  [MGI Ref ID J:150310]

Cobb D; Hambright D; Smeltz RB. 2010. T-bet-independent effects of IL-12 family cytokines on regulation of Th17 responses to experimental T. cruzi infection. J Leukoc Biol 88(5):965-71. [PubMed: 20807701]  [MGI Ref ID J:166092]

Codarri L; Gyulveszi G; Tosevski V; Hesske L; Fontana A; Magnenat L; Suter T; Becher B. 2011. RORgammat drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat Immunol 12(6):560-7. [PubMed: 21516112]  [MGI Ref ID J:172802]

Coers J; Gondek DC; Olive AJ; Rohlfing A; Taylor GA; Starnbach MN. 2011. Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections. PLoS Pathog 7(6):e1001346. [PubMed: 21731484]  [MGI Ref ID J:182190]

Cohen M; Elkabets M; Perlmutter M; Porgador A; Voronov E; Apte RN; Lichtenstein RG. 2010. Sialylation of 3-methylcholanthrene-induced fibrosarcoma determines antitumor immune responses during immunoediting. J Immunol 185(10):5869-78. [PubMed: 20956342]  [MGI Ref ID J:165779]

Cohn L; Herrick C; Niu N; Homer R; Bottomly K. 2001. IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation. J Immunol 166(4):2760-7. [PubMed: 11160342]  [MGI Ref ID J:126916]

Collazo CM; Meierovics AI; De Pascalis R; Wu TH; Lyons CR; Elkins KL. 2009. T cells from lungs and livers of Francisella tularensis-immune mice control the growth of intracellular bacteria. Infect Immun 77(5):2010-21. [PubMed: 19237526]  [MGI Ref ID J:148524]

Collins JT; Shi J; Burrell BE; Bishop DK; Dunnick WA. 2006. Induced expression of murine gamma2a by CD40 ligation independently of IFN-gamma. J Immunol 177(8):5414-9. [PubMed: 17015727]  [MGI Ref ID J:139436]

Combe CL; Moretto MM; Schwartzman JD; Gigley JP; Bzik DJ; Khan IA. 2006. Lack of IL-15 results in the suboptimal priming of CD4+ T cell response against an intracellular parasite. Proc Natl Acad Sci U S A 103(17):6635-40. [PubMed: 16614074]  [MGI Ref ID J:109105]

Cone RE; Li X; Sharafieh R; O'Rourke J; Vella AT. 2007. The suppression of delayed-type hypersensitivity by CD8+ regulatory T cells requires interferon-gamma. Immunology 120(1):112-9. [PubMed: 17052246]  [MGI Ref ID J:122316]

Cooper AM; Dalton DK; Stewart TA; Griffin JP; Russell DG; Orme IM. 1993. Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med 178(6):2243-7. [PubMed: 8245795]  [MGI Ref ID J:15723]

Copin R; Vitry MA; Hanot Mambres D; Machelart A; De Trez C; Vanderwinden JM; Magez S; Akira S; Ryffel B; Carlier Y; Letesson JJ; Muraille E. 2012. In situ microscopy analysis reveals local innate immune response developed around Brucella infected cells in resistant and susceptible mice. PLoS Pathog 8(3):e1002575. [PubMed: 22479178]  [MGI Ref ID J:195395]

Cornish AL; Chong MM; Davey GM; Darwiche R; Nicola NA; Hilton DJ; Kay TW; Starr R; Alexander WS. 2003. Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells. J Biol Chem 278(25):22755-61. [PubMed: 12665516]  [MGI Ref ID J:124411]

Cornish AL; Davey GM; Metcalf D; Purton JF; Corbin JE; Greenhalgh CJ; Darwiche R; Wu L; Nicola NA; Godfrey DI; Heath WR; Hilton DJ; Alexander WS; Starr R. 2003. Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis. J Immunol 170(2):878-86. [PubMed: 12517953]  [MGI Ref ID J:127134]

Costigan M; Moss A; Latremoliere A; Johnston C; Verma-Gandhu M; Herbert TA; Barrett L; Brenner GJ; Vardeh D; Woolf CJ; Fitzgerald M. 2009. T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity. J Neurosci 29(46):14415-22. [PubMed: 19923276]  [MGI Ref ID J:158280]

Coursey TG; Chen PW; Niederkorn JY. 2011. Abrogating TNF-{alpha} Expression Prevents Bystander Destruction of Normal Tissues during iNOS-Mediated Elimination of Intraocular Tumors. Cancer Res 71(7):2445-54. [PubMed: 21307132]  [MGI Ref ID J:170908]

Coursey TG; Chen PW; Niederkorn JY. 2011. IL-17-dependent, IFN-gamma-independent tumor rejection is mediated by cytotoxic T lymphocytes and occurs at extraocular sites, but is excluded from the eye. J Immunol 187(8):4219-28. [PubMed: 21918192]  [MGI Ref ID J:179307]

Cretney E; Takeda K; Yagita H; Glaccum M; Peschon JJ; Smyth MJ. 2002. Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice. J Immunol 168(3):1356-61. [PubMed: 11801676]  [MGI Ref ID J:73948]

Croker B; Crozat K; Berger M; Xia Y; Sovath S; Schaffer L; Eleftherianos I; Imler JL; Beutler B. 2007. ATP-sensitive potassium channels mediate survival during infection in mammals and insects. Nat Genet 39(12):1453-60. [PubMed: 18026101]  [MGI Ref ID J:126658]

Croom HA; Izon DJ; Chong MM; Curtis DJ; Roberts AW; Kay TW; Hilton DJ; Alexander WS; Starr R. 2008. Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3. Mol Immunol 45(10):2888-96. [PubMed: 18321577]  [MGI Ref ID J:134472]

Cruz A; Khader SA; Torrado E; Fraga A; Pearl JE; Pedrosa J; Cooper AM; Castro AG. 2006. Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection. J Immunol 177(3):1416-20. [PubMed: 16849446]  [MGI Ref ID J:137981]

Cuff S; Dolton G; Matthews RJ; Gallimore A. 2010. Antigen specificity determines the pro- or antitumoral nature of CD8+ T cells. J Immunol 184(2):607-14. [PubMed: 20007540]  [MGI Ref ID J:159412]

Curtsinger JM; Agarwal P; Lins DC; Mescher MF. 2012. Autocrine IFN-gamma promotes naive CD8 T cell differentiation and synergizes with IFN-alpha to stimulate strong function. J Immunol 189(2):659-68. [PubMed: 22706089]  [MGI Ref ID J:189538]

Dai JH; Iwatani Y; Ishida T; Terunuma H; Kasai H; Iwakula Y; Fujiwara H; Ito M. 2001. Glycyrrhizin enhances interleukin-12 production in peritoneal macrophages. Immunology 103(2):235-43. [PubMed: 11412311]  [MGI Ref ID J:69773]

Dalton DK; Haynes L; Chu CQ; Swain SL; Wittmer S. 2000. Interferon gamma eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells. J Exp Med 192(1):117-22. [PubMed: 10880532]  [MGI Ref ID J:115328]

Dandekar AA; Anghelina D; Perlman S. 2004. Bystander CD8 T-cell-mediated demyelination is interferon-gamma-dependent in a coronavirus model of multiple sclerosis. Am J Pathol 164(2):363-9. [PubMed: 14742242]  [MGI Ref ID J:88552]

Davey GM; Starr R; Cornish AL; Burghardt JT; Alexander WS; Carbone FR; Surh CD; Heath WR. 2005. SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential. J Exp Med 202(8):1099-108. [PubMed: 16216888]  [MGI Ref ID J:116818]

De Colvenaer V; Taveirne S; Hamann J; de Bruin AM; De Smedt M; Taghon T; Vandekerckhove B; Plum J; van Lier R; Leclercq G. 2010. Continuous CD27 triggering in vivo strongly reduces NK cell numbers. Eur J Immunol 40(4):1107-17. [PubMed: 20140903]  [MGI Ref ID J:159189]

De Paiva CS; Chotikavanich S; Pangelinan SB; Pitcher JD 3rd; Fang B; Zheng X; Ma P; Farley WJ; Siemasko KF; Niederkorn JY; Stern ME; Li DQ; Pflugfelder SC. 2009. IL-17 disrupts corneal barrier following desiccating stress. Mucosal Immunol 2(3):243-53. [PubMed: 19242409]  [MGI Ref ID J:191918]

De Paiva CS; Villarreal AL; Corrales RM; Rahman HT; Chang VY; Farley WJ; Stern ME; Niederkorn JY; Li DQ; Pflugfelder SC. 2007. Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. Invest Ophthalmol Vis Sci 48(6):2553-60. [PubMed: 17525184]  [MGI Ref ID J:123281]

Deepe GS Jr; Gibbons RS. 2008. TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis. J Immunol 180(2):1088-97. [PubMed: 18178849]  [MGI Ref ID J:130944]

Demaude J; Salvador-Cartier C; Fioramonti J; Ferrier L; Bueno L. 2006. Phenotypic changes in colonocytes following acute stress or activation of mast cells in mice: implications for delayed epithelial barrier dysfunction. Gut 55(5):655-61. [PubMed: 16299034]  [MGI Ref ID J:195107]

Deng Y; Guo X; Ferguson DO; Chang S. 2009. Multiple roles for MRE11 at uncapped telomeres. Nature 460(7257):914-8. [PubMed: 19633651]  [MGI Ref ID J:151777]

Ding Q; Lu L; Wang B; Zhou Y; Jiang Y; Zhou X; Xin L; Jiao Z; Chou KY. 2006. B7H1-Ig fusion protein activates the CD4+ IFN-gamma receptor+ type 1 T regulatory subset through IFN-gamma-secreting Th1 cells. J Immunol 177(6):3606-14. [PubMed: 16951320]  [MGI Ref ID J:138053]

Do JS; Visperas A; Oh K; Stohlman SA; Min B. 2012. Memory CD4 T cells induce selective expression of IL-27 in CD8+ dendritic cells and regulate homeostatic naive T cell proliferation. J Immunol 188(1):230-7. [PubMed: 22116827]  [MGI Ref ID J:180589]

Dogan RN; Vasu C; Holterman MJ; Prabhakar BS. 2003. Absence of IL-4, and not suppression of the Th2 response, prevents development of experimental autoimmune Graves' disease. J Immunol 170(4):2195-204. [PubMed: 12574393]  [MGI Ref ID J:126279]

Doherty TM; Sher A. 1997. Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection. J Immunol 158(10):4822-31. [PubMed: 9144497]  [MGI Ref ID J:40202]

Dohi T; Fujihashi K; Kiyono H; Elson CO; McGhee JR. 2000. Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis. Gastroenterology 119(3):724-33. [PubMed: 10982767]  [MGI Ref ID J:64230]

Dohi T; Fujihashi K; Koga T; Etani Y; Yoshino N; Kawamura YI; McGhee JR. 2004. CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis. Am J Pathol 165(4):1257-68. [PubMed: 15466391]  [MGI Ref ID J:93676]

Dohi T; Fujihashi K; Koga T; Shirai Y; Kawamura YI; Ejima C; Kato R; Saitoh K; McGhee JR. 2003. T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell-deficient mice. Gastroenterology 124(3):672-82. [PubMed: 12612906]  [MGI Ref ID J:82106]

Dohi T; Fujihashi K; Rennert PD; Iwatani K; Kiyono H; McGhee JR. 1999. Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses. J Exp Med 189(8):1169-80. [PubMed: 10209035]  [MGI Ref ID J:119172]

Dokun AO; Chu DT; Yang L; Bendelac AS; Yokoyama WM. 2001. Analysis of in situ NK cell responses during viral infection. J Immunol 167(9):5286-93. [PubMed: 11673544]  [MGI Ref ID J:72673]

Doodes PD; Cao Y; Hamel KM; Wang Y; Farkas B; Iwakura Y; Finnegan A. 2008. Development of proteoglycan-induced arthritis is independent of IL-17. J Immunol 181(1):329-37. [PubMed: 18566398]  [MGI Ref ID J:137406]

Doodes PD; Cao Y; Hamel KM; Wang Y; Rodeghero RL; Mikecz K; Glant TT; Iwakura Y; Finnegan A. 2010. IFN-gamma regulates the requirement for IL-17 in proteoglycan-induced arthritis. J Immunol 184(3):1552-9. [PubMed: 20028652]  [MGI Ref ID J:159538]

Doolan DL; Hoffman SL. 1999. IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii model. J Immunol 163(2):884-92. [PubMed: 10395683]  [MGI Ref ID J:119784]

Dougan M; Li D; Neuberg D; Mihm M; Googe P; Wong KK; Dranoff G. 2011. A dual role for the immune response in a mouse model of inflammation-associated lung cancer. J Clin Invest 121(6):2436-46. [PubMed: 21537082]  [MGI Ref ID J:173919]

Downs I; Liu J; Aw TY; Adegboyega PA; Ajuebor MN. 2012. The ROS scavenger, NAC, regulates hepatic Valpha14iNKT cells signaling during Fas mAb-dependent fulminant liver failure. PLoS One 7(6):e38051. [PubMed: 22701598]  [MGI Ref ID J:187842]

Drevets DA; Schawang JE; Dillon MJ; Lerner MR; Bronze MS; Brackett DJ. 2008. Innate responses to systemic infection by intracellular bacteria trigger recruitment of Ly-6Chigh monocytes to the brain. J Immunol 181(1):529-36. [PubMed: 18566419]  [MGI Ref ID J:137399]

Dubey JP; Liddell S; Mattson D; Speert CA; Howe DK; Jenkins MC. 2001. Characterization of the Oregon isolate of Neospora hughesi from a horse. J Parasitol 87(2):345-53. [PubMed: 11318565]  [MGI Ref ID J:109880]

Dubois A; Deruytter N; Adams B; Kanda A; Delbauve S; Fleury S; Torres D; Francois A; Petein M; Goldman M; Dombrowicz D; Flamand V. 2010. Regulation of Th2 responses and allergic inflammation through bystander activation of CD8+ T lymphocytes in early life. J Immunol 185(2):884-91. [PubMed: 20562264]  [MGI Ref ID J:161925]

Dugan CM; Fullerton AM; Roth RA; Ganey PE. 2011. Natural killer cells mediate severe liver injury in a murine model of halothane hepatitis. Toxicol Sci 120(2):507-18. [PubMed: 21245496]  [MGI Ref ID J:171014]

Dunussi-Joannopoulos K; Hancock GE; Kunz A; Hegen M; Zhou XX; Sheppard BJ; Lamothe J; Li E; Ma HL; Hamann PR; Damle NK; Collins M. 2005. B-cell depletion inhibits arthritis in a collagen-induced arthritis (CIA) model, but does not adversely affect humoral responses in a respiratory syncytial virus (RSV) vaccination model. Blood 106(7):2235-43. [PubMed: 15947095]  [MGI Ref ID J:119369]

Durbin JE; Fernandez-Sesma A; Lee CK; Rao TD; Frey AB; Moran TM; Vukmanovic S; Garcia-Sastre A; Levy DE. 2000. Type I IFN modulates innate and specific antiviral immunity. J Immunol 164(8):4220-8. [PubMed: 10754318]  [MGI Ref ID J:123432]

Durbin JE; Johnson TR; Durbin RK; Mertz SE; Morotti RA; Peebles RS; Graham BS. 2002. The role of IFN in respiratory syncytial virus pathogenesis. J Immunol 168(6):2944-52. [PubMed: 11884466]  [MGI Ref ID J:126678]

Eaton KA; Mefford M; Thevenot T. 2001. The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice. J Immunol 166(12):7456-61. [PubMed: 11390498]  [MGI Ref ID J:124425]

Eberle ME; Dalpke AH. 2012. Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses. J Immunol 188(11):5644-54. [PubMed: 22547696]  [MGI Ref ID J:188728]

Echeverry A; Saijo S; Schesser K; Adkins B. 2010. Yersinia enterocolitica promotes robust mucosal inflammatory T-cell immunity in murine neonates. Infect Immun 78(8):3595-608. [PubMed: 20515925]  [MGI Ref ID J:161817]

Egan CE; Craven MD; Leng J; Mack M; Simpson KW; Denkers EY. 2009. CCR2-dependent intraepithelial lymphocytes mediate inflammatory gut pathology during Toxoplasma gondii infection. Mucosal Immunol 2(6):527-35. [PubMed: 19741601]  [MGI Ref ID J:193378]

Egan PJ; Lawlor KE; Alexander WS; Wicks IP. 2003. Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation. J Clin Invest 111(6):915-24. [PubMed: 12639998]  [MGI Ref ID J:82519]

Eigenbrod T; Bode KA; Dalpke AH. 2013. Early inhibition of IL-1beta expression by IFN-gamma is mediated by impaired binding of NF-kappaB to the IL-1beta promoter but is independent of nitric oxide. J Immunol 190(12):6533-41. [PubMed: 23667107]  [MGI Ref ID J:204860]

Eisenring M; vom Berg J; Kristiansen G; Saller E; Becher B. 2010. IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46. Nat Immunol 11(11):1030-8. [PubMed: 20935648]  [MGI Ref ID J:166535]

El-Assaad F; Hempel C; Combes V; Mitchell AJ; Ball HJ; Kurtzhals JA; Hunt NH; Mathys JM; Grau GE. 2011. Differential MicroRNA Expression in Experimental Cerebral and Noncerebral Malaria. Infect Immun 79(6):2379-84. [PubMed: 21422175]  [MGI Ref ID J:171928]

Elboim M; Gazit R; Gur C; Ghadially H; Betser-Cohen G; Mandelboim O. 2010. Tumor immunoediting by NKp46. J Immunol 184(10):5637-44. [PubMed: 20404273]  [MGI Ref ID J:160984]

Ellison CA; Fischer JM; HayGlass KT; Gartner JG. 1998. Murine graft-versus-host disease in an F1-hybrid model using IFN-gamma gene knockout donors. J Immunol 161(2):631-40. [PubMed: 9670937]  [MGI Ref ID J:48545]

Ely KH; Kasper LH; Khan IA. 1999. Augmentation of the CD8+ T cell response by IFN-gamma in IL-12-deficient mice during Toxoplasma gondii infection. J Immunol 162(9):5449-54. [PubMed: 10228024]  [MGI Ref ID J:111011]

Enzler T; Gillessen S; Dougan M; Allison JP; Neuberg D; Oble DA; Mihm M; Dranoff G. 2007. Functional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3 contribute to insulitis and destruction of beta cells. Blood 110(3):954-61. [PubMed: 17483299]  [MGI Ref ID J:145518]

Enzler T; Gillessen S; Manis JP; Ferguson D; Fleming J; Alt FW; Mihm M; Dranoff G. 2003. Deficiencies of GM-CSF and interferon gamma link inflammation and cancer. J Exp Med 197(9):1213-9. [PubMed: 12732663]  [MGI Ref ID J:83086]

Erie AJ; Samsel L; Takaku T; Desierto MJ; Keyvanfar K; McCoy JP; Young NS; Chen J. 2011. MHC class II upregulation and colocalization with Fas in experimental models of immune-mediated bone marrow failure. Exp Hematol 39(8):837-49. [PubMed: 21635935]  [MGI Ref ID J:186746]

Eriksson U; Kurrer MO; Sebald W; Brombacher F; Kopf M. 2001. Dual role of the IL-12/IFN-gamma axis in the development of autoimmune myocarditis: induction by IL-12 and protection by IFN-gamma. J Immunol 167(9):5464-9. [PubMed: 11673566]  [MGI Ref ID J:72665]

Evel-Kabler K; Song XT; Aldrich M; Huang XF; Chen SY. 2006. SOCS1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling. J Clin Invest 116(1):90-100. [PubMed: 16357940]  [MGI Ref ID J:105256]

Eyles JL; Metcalf D; Grusby MJ; Hilton DJ; Starr R. 2002. Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1. J Biol Chem 277(46):43735-40. [PubMed: 12221108]  [MGI Ref ID J:119132]

Fairweather D; Frisancho-Kiss S; Yusung SA; Barrett MA; Davis SE; Gatewood SJ; Njoku DB; Rose NR. 2004. Interferon-gamma protects against chronic viral myocarditis by reducing mast cell degranulation, fibrosis, and the profibrotic cytokines transforming growth factor-beta 1, interleukin-1 beta, and interleukin-4 in the heart. Am J Pathol 165(6):1883-94. [PubMed: 15579433]  [MGI Ref ID J:94973]

Fairweather D; Frisancho-Kiss S; Yusung SA; Barrett MA; Davis SE; Steele RA; Gatewood SJ; Rose NR. 2005. IL-12 protects against coxsackievirus B3-induced myocarditis by increasing IFN-gamma and macrophage and neutrophil populations in the heart. J Immunol 174(1):261-9. [PubMed: 15611248]  [MGI Ref ID J:95857]

Fairweather D; Yusung S; Frisancho S; Barrett M; Gatewood S; Steele R; Rose NR. 2003. IL-12 Receptor beta1 and Toll-Like Receptor 4 Increase IL-1beta- and IL-18-Associated Myocarditis and Coxsackievirus Replication. J Immunol 170(9):4731-7. [PubMed: 12707353]  [MGI Ref ID J:83020]

Fallarino F; Bianchi R; Orabona C; Vacca C; Belladonna ML; Fioretti MC; Serreze DV; Grohmann U; Puccetti P. 2004. CTLA-4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice. J Exp Med 200(8):1051-62. [PubMed: 15492127]  [MGI Ref ID J:93957]

Fang M; Xie H; Dougan SK; Ploegh H; van Oudenaarden A. 2013. Stochastic cytokine expression induces mixed T helper cell States. PLoS Biol 11(7):e1001618. [PubMed: 23935453]  [MGI Ref ID J:201603]

Fang Y; Chen K; Jackson DA; Sharp GC; Braley-Mullen H. 2010. Eosinophils infiltrate thyroids, but have no apparent role in induction or resolution of experimental autoimmune thyroiditis in interferon-gamma(-/-) mice. Immunology 129(3):329-37. [PubMed: 19845793]  [MGI Ref ID J:166199]

Fang Y; Yu S; Braley-Mullen H. 2012. TGF-beta Promotes Proliferation of Thyroid Epithelial Cells in IFN-gamma(-/-) Mice by Down-Regulation of p21 and p27 via AKT Pathway. Am J Pathol 180(2):650-60. [PubMed: 22119715]  [MGI Ref ID J:180437]

Feng CG; Kaviratne M; Rothfuchs AG; Cheever A; Hieny S; Young HA; Wynn TA; Sher A. 2006. NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis. J Immunol 177(10):7086-93. [PubMed: 17082625]  [MGI Ref ID J:140483]

Feng CG; Scanga CA; Collazo-Custodio CM; Cheever AW; Hieny S; Caspar P; Sher A. 2003. Mice lacking myeloid differentiation factor 88 display profound defects in host resistance and immune responses to Mycobacterium avium infection not exhibited by Toll-like receptor 2 (TLR2)- and TLR4-deficient animals. J Immunol 171(9):4758-64. [PubMed: 14568952]  [MGI Ref ID J:118915]

Feng CG; Zheng L; Jankovic D; Bafica A; Cannons JL; Watford WT; Chaussabel D; Hieny S; Caspar P; Schwartzberg PL; Lenardo MJ; Sher A. 2008. The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. Nat Immunol 9(11):1279-87. [PubMed: 18806793]  [MGI Ref ID J:142840]

Feng HM; Walker DH. 2004. Mechanisms of immunity to Ehrlichia muris: a model of monocytotropic ehrlichiosis. Infect Immun 72(2):966-71. [PubMed: 14742542]  [MGI Ref ID J:87862]

Fenner JE; Starr R; Cornish AL; Zhang JG; Metcalf D; Schreiber RD; Sheehan K; Hilton DJ; Alexander WS; Hertzog PJ. 2006. Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity. Nat Immunol 7(1):33-9. [PubMed: 16311601]  [MGI Ref ID J:112593]

Ferber IA; Brocke S; Taylor-Edwards C; Ridgway W; Dinisco C; Steinman L; Dalton D; Fathman CG. 1996. Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol 156(1):5-7. [PubMed: 8598493]  [MGI Ref ID J:30237]

Feuerer M; Eulenburg K; Loddenkemper C; Hamann A; Huehn J. 2006. Self-limitation of Th1-mediated inflammation by IFN-gamma. J Immunol 176(5):2857-63. [PubMed: 16493042]  [MGI Ref ID J:129422]

Finnegan A; Grusby MJ; Kaplan CD; O'Neill SK; Eibel H; Koreny T; Czipri M; Mikecz K; Zhang J. 2002. IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms. J Immunol 169(6):3345-52. [PubMed: 12218156]  [MGI Ref ID J:120443]

Fischer R; Tome D; McGhee JR; Boyaka PN. 2007. Th1 and Th2 cells are required for both eosinophil- and neutrophil-associated airway inflammatory responses in mice. Biochem Biophys Res Commun 357(1):44-9. [PubMed: 17412309]  [MGI Ref ID J:121793]

Flaishon L; Hershkoviz R; Lantner F; Lider O; Alon R; Levo Y; Flavell RA; Shachar I. 2000. Autocrine secretion of interferon gamma negatively regulates homing of immature B cells. J Exp Med 192(9):1381-8. [PubMed: 11067886]  [MGI Ref ID J:112084]

Flano E; Woodland DL; Blackman MA. 1999. Requirement for CD4+ T cells in V beta 4+CD8+ T cell activation associated with latent murine gammaherpesvirus infection. J Immunol 163(6):3403-8. [PubMed: 10477611]  [MGI Ref ID J:119171]

Florido M; Borges M; Rodrigues P; Vale-Costa S; Salome Gomes M; Appelberg R. 2009. Constitutive expression of Bcl-2 in the haematopoietic compartment alters the metabolism of iron and increases resistance to mycobacterial infection. Clin Exp Immunol 156(1):61-8. [PubMed: 19210523]  [MGI Ref ID J:146435]

Florido M; Pearl JE; Solache A; Borges M; Haynes L; Cooper AM; Appelberg R. 2005. Gamma interferon-induced T-cell loss in virulent Mycobacterium avium infection. Infect Immun 73(6):3577-86. [PubMed: 15908387]  [MGI Ref ID J:99143]

Flynn JL; Chan J; Triebold KJ; Dalton DK; Stewart TA; Bloom BR. 1993. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med 178(6):2249-54. [PubMed: 7504064]  [MGI Ref ID J:110856]

Flynn JL; Goldstein MM; Triebold KJ; Sypek J; Wolf S; Bloom BR. 1995. IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection. J Immunol 155(5):2515-24. [PubMed: 7650381]  [MGI Ref ID J:28196]

Fogler WE; Volker K; Watanabe M; Wigginton JM; Roessler P; Brunda MJ; Ortaldo JR; Wiltrout RH. 1998. Recruitment of hepatic NK cells by IL-12 is dependent on IFN-gamma and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas. J Immunol 161(11):6014-21. [PubMed: 9834083]  [MGI Ref ID J:115033]

Fox BA; Bzik DJ. 2010. Avirulent uracil auxotrophs based on disruption of orotidine-5'-monophosphate decarboxylase elicit protective immunity to Toxoplasma gondii. Infect Immun 78(9):3744-52. [PubMed: 20605980]  [MGI Ref ID J:163001]

France MP; Smith AL; Stevenson R; Barthold SW. 1999. Granulomatous peritonitis and pleuritis in interferon-gamma gene knockout mice naturally infected with mouse hepatitis virus. Aust Vet J 77(9):600-4. [PubMed: 10561796]  [MGI Ref ID J:59661]

Franklin BS; Parroche P; Ataide MA; Lauw F; Ropert C; de Oliveira RB; Pereira D; Tada MS; Nogueira P; da Silva LH; Bjorkbacka H; Golenbock DT; Gazzinelli RT. 2009. Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function. Proc Natl Acad Sci U S A 106(14):5789-94. [PubMed: 19297619]  [MGI Ref ID J:147570]

Frazer LC; Sullivan JE; Zurenski MA; Mintus M; Tomasak TE; Prantner D; Nagarajan UM; Darville T. 2013. CD4+ T cell expression of MyD88 is essential for normal resolution of Chlamydia muridarum genital tract infection. J Immunol 191(8):4269-79. [PubMed: 24038087]  [MGI Ref ID J:206277]

Freyschmidt-Paul P; McElwee KJ; Hoffmann R; Sundberg JP; Vitacolonna M; Kissling S; Zoller M. 2006. Interferon-gamma-deficient mice are resistant to the development of alopecia areata. Br J Dermatol 155(3):515-21. [PubMed: 16911275]  [MGI Ref ID J:135859]

Frisancho-Kiss S; Davis SE; Nyland JF; Frisancho JA; Cihakova D; Barrett MA; Rose NR; Fairweather D. 2007. Cutting edge: cross-regulation by TLR4 and T cell Ig mucin-3 determines sex differences in inflammatory heart disease. J Immunol 178(11):6710-4. [PubMed: 17513715]  [MGI Ref ID J:147853]

Fritz RB; Zhao ML. 2001. Regulation of experimental autoimmune encephalomyelitis in the C57BL/6J mouse by NK1.1+, DX5+, alpha beta+ T cells. J Immunol 166(6):4209-15. [PubMed: 11238673]  [MGI Ref ID J:126134]

Fujigaki S; Saito K; Sekikawa K; Tone S; Takikawa O; Fujii H; Wada H; Noma A; Seishima M. 2001. Lipopolysaccharide induction of indoleamine 2,3-dioxygenase is mediated dominantly by an IFN-gamma-independent mechanism. Eur J Immunol 31(8):2313-8. [PubMed: 11477543]  [MGI Ref ID J:71158]

Fukushima A; Yamaguchi T; Ishida W; Fukata K; Mittler RS; Yagita H; Ueno H. 2005. Engagement of 4-1BB inhibits the development of experimental allergic conjunctivitis in mice. J Immunol 175(8):4897-903. [PubMed: 16210591]  [MGI Ref ID J:119054]

Fukushima A; Yamaguchi T; Ishida W; Fukata K; Taniguchi T; Liu FT; Ueno H. 2006. Genetic background determines susceptibility to experimental immune-mediated blepharoconjunctivitis: comparison of Balb/c and C57BL/6 mice. Exp Eye Res 82(2):210-8. [PubMed: 16102751]  [MGI Ref ID J:106441]

Fukuyama S; Nakano T; Matsumoto T; Oliver BG; Burgess JK; Moriwaki A; Tanaka K; Kubo M; Hoshino T; Tanaka H; McKenzie AN; Matsumoto K; Aizawa H; Nakanishi Y; Yoshimura A; Black JL; Inoue H. 2009. Pulmonary suppressor of cytokine signaling-1 induced by IL-13 regulates allergic asthma phenotype. Am J Respir Crit Care Med 179(11):992-8. [PubMed: 19299500]  [MGI Ref ID J:164975]

Fullerton AM; Roth RA; Ganey PE. 2013. 2,3,7,8-TCDD enhances the sensitivity of mice to concanavalin A immune-mediated liver injury. Toxicol Appl Pharmacol 266(2):317-27. [PubMed: 23164664]  [MGI Ref ID J:193201]

Gajendran N; Mittrucker HW; Bordasch K; Heinemann E; Koch M; Kaufmann SH. 2007. Regional IFN{gamma} expression is insufficient for efficacious control of food-borne bacterial pathogens at the gut epithelial barrier. Int Immunol 19(9):1075-81. [PubMed: 17698562]  [MGI Ref ID J:124869]

Gallina G; Dolcetti L; Serafini P; De Santo C; Marigo I; Colombo MP; Basso G; Brombacher F; Borrello I; Zanovello P; Bicciato S; Bronte V. 2006. Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J Clin Invest 116(10):2777-90. [PubMed: 17016559]  [MGI Ref ID J:114986]

Gao D; Kasten-Jolly J; Lawrence DA. 2006. The paradoxical effects of lead in interferon-gamma knockout BALB/c mice. Toxicol Sci 89(2):444-53. [PubMed: 16280381]  [MGI Ref ID J:113282]

Gao JJ; Filla MB; Fultz MJ; Vogel SN; Russell SW; Murphy WJ. 1998. Autocrine/paracrine IFN-alphabeta mediates the lipopolysaccharide-induced activation of transcription factor Stat1alpha in mouse macrophages: pivotal role of Stat1alpha in induction of the inducible nitric oxide synthase gene. J Immunol 161(9):4803-10. [PubMed: 9794412]  [MGI Ref ID J:115235]

Gao N; Dang T; Dunnick WA; Collins JT; Blazar BR; Yuan D. 2005. Receptors and counterreceptors involved in NK-B cell interactions. J Immunol 174(7):4113-9. [PubMed: 15778370]  [MGI Ref ID J:97960]

Gao N; Jennings P; Yuan D. 2008. Requirements for the natural killer cell-mediated induction of IgG1 and IgG2a expression in B lymphocytes. Int Immunol 20(5):645-57. [PubMed: 18339657]  [MGI Ref ID J:134466]

Gao X; Gillig TA; Ye P; D'Ercole AJ; Matsushima GK; Popko B. 2000. Interferon-gamma protects against cuprizone-induced demyelination Mol Cell Neurosci 16(4):338-49. [PubMed: 11085872]  [MGI Ref ID J:65508]

Gao Y; Grassi F; Ryan MR; Terauchi M; Page K; Yang X; Weitzmann MN; Pacifici R. 2007. IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation. J Clin Invest 117(1):122-32. [PubMed: 17173138]  [MGI Ref ID J:117462]

Gao Y; Li Z; Hassan N; Mehta P; Burns AR; Tang X; Smith CW. 2013. NK cells are necessary for recovery of corneal CD11c+ dendritic cells after epithelial abrasion injury. J Leukoc Biol 94(2):343-51. [PubMed: 23695308]  [MGI Ref ID J:203224]

Gao Y; Tao J; Li MO; Zhang D; Chi H; Henegariu O; Kaech SM; Davis RJ; Flavell RA; Yin Z. 2005. JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance. J Immunol 175(9):5783-9. [PubMed: 16237070]  [MGI Ref ID J:119340]

Garcia AG; Wilson RM; Heo J; Murthy NR; Baid S; Ouchi N; Sam F. 2012. Interferon-gamma ablation exacerbates myocardial hypertrophy in diastolic heart failure. Am J Physiol Heart Circ Physiol 303(5):H587-96. [PubMed: 22730392]  [MGI Ref ID J:189195]

Ge MQ; Ho AW; Tang Y; Wong KH; Chua BY; Gasser S; Kemeny DM. 2012. NK cells regulate CD8+ T cell priming and dendritic cell migration during influenza A infection by IFN-gamma and perforin-dependent mechanisms. J Immunol 189(5):2099-109. [PubMed: 22869906]  [MGI Ref ID J:189840]

Gentil K; Pearlman E. 2009. Gamma interferon and interleukin-1 receptor 1 regulate neutrophil recruitment to the corneal stroma in a murine model of Onchocerca volvulus keratitis. Infect Immun 77(4):1606-12. [PubMed: 19168746]  [MGI Ref ID J:147171]

Gerber SA; Sedlacek AL; Cron KR; Murphy SP; Frelinger JG; Lord EM. 2013. IFN-gamma mediates the antitumor effects of radiation therapy in a murine colon tumor. Am J Pathol 182(6):2345-54. [PubMed: 23583648]  [MGI Ref ID J:198468]

Gerber SA; Sorensen EW; Sedlacek AL; Lim JY; Skrombolas D; Frelinger JG; Lord EM. 2013. Local expression of interleukin-2 by B16 melanoma cells results in decreased tumour growth and long-term tumour dormancy. Immunology 138(3):280-92. [PubMed: 23198850]  [MGI Ref ID J:198085]

Gerbitz A; Sukumar M; Helm F; Wilke A; Friese C; Fahrenwaldt C; Lehmann FM; Loddenkemper C; Kammertoens T; Mautner J; Schmitt CA; Blankenstein T; Bornkamm GW. 2012. Stromal interferon-gamma signaling and cross-presentation are required to eliminate antigen-loss variants of B cell lymphomas in mice. PLoS One 7(3):e34552. [PubMed: 22479645]  [MGI Ref ID J:187120]

Getahun A; Smith MJ; Kogut I; van Dyk LF; Cambier JC. 2012. Retention of anergy and inhibition of antibody responses during acute gamma herpesvirus 68 infection. J Immunol 189(6):2965-74. [PubMed: 22904300]  [MGI Ref ID J:189918]

Gibbons DL; Haque SF; Copestake SL; Wells JW; Noble A; Smith AL; Hayday AC. 2009. Suppression of airway inflammation by a natural acute infection of the intestinal epithelium. Mucosal Immunol 2(2):144-55. [PubMed: 19129755]  [MGI Ref ID J:191921]

Gigley JP; Fox BA; Bzik DJ. 2009. Cell-mediated immunity to Toxoplasma gondii develops primarily by local Th1 host immune responses in the absence of parasite replication. J Immunol 182(2):1069-78. [PubMed: 19124750]  [MGI Ref ID J:143485]

Gill N; Deacon PM; Lichty B; Mossman KL; Ashkar AA. 2006. Induction of innate immunity against herpes simplex virus type 2 infection via local delivery of Toll-like receptor ligands correlates with beta interferon production. J Virol 80(20):9943-50. [PubMed: 17005672]  [MGI Ref ID J:153329]

Gingras S; Parganas E; de Pauw A; Ihle JN; Murray PJ. 2004. Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling. J Biol Chem 279(52):54702-7. [PubMed: 15491990]  [MGI Ref ID J:95152]

Glabinski AR; Krakowski M; Han Y; Owens T; Ransohoff RM. 1999. Chemokine expression in GKO mice (lacking interferon-gamma) with experimental autoimmune encephalomyelitis. J Neurovirol 5(1):95-101. [PubMed: 10190695]  [MGI Ref ID J:53694]

Goes N; Sims T; Urmson J; Vincent D; Ramassar V; Halloran PF. 1995. Disturbed MHC regulation in the IFN-gamma knockout mouse. Evidence for three states of MHC expression with distinct roles for IFN-gamma. J Immunol 155(10):4559-66. [PubMed: 7594453]  [MGI Ref ID J:29680]

Goes N; Urmson J; Hobart M; Halloran PF. 1996. The unique role of interferon-gamma in the regulation of MHC expression on arterial endothelium. Transplantation 62(12):1889-94. [PubMed: 8990382]  [MGI Ref ID J:37405]

Goes N; Urmson J; Vincent D; Halloran PF. 1995. Acute renal injury in the interferon-gamma gene knockout mouse: effect on cytokine gene expression. Transplantation 60(12):1560-4. [PubMed: 8545890]  [MGI Ref ID J:31381]

Gokmen MR; Dong R; Kanhere A; Powell N; Perucha E; Jackson I; Howard JK; Hernandez-Fuentes M; Jenner RG; Lord GM. 2013. Genome-wide regulatory analysis reveals that T-bet controls Th17 lineage differentiation through direct suppression of IRF4. J Immunol 191(12):5925-32. [PubMed: 24249732]  [MGI Ref ID J:207104]

Goktuna SI; Canli O; Bollrath J; Fingerle AA; Horst D; Diamanti MA; Pallangyo C; Bennecke M; Nebelsiek T; Mankan AK; Lang R; Artis D; Hu Y; Patzelt T; Ruland J; Kirchner T; Taketo MM; Chariot A; Arkan MC; Greten FR. 2014. IKKalpha Promotes Intestinal Tumorigenesis by Limiting Recruitment of M1-like Polarized Myeloid Cells. Cell Rep 7(6):1914-25. [PubMed: 24882009]  [MGI Ref ID J:211784]

Goldman KP; Park CS; Kim M; Matzinger P; Anderson CC. 2005. Thymic cortical epithelium induces self tolerance. Eur J Immunol 35(3):709-17. [PubMed: 15719367]  [MGI Ref ID J:96619]

Goldszmid RS; Bafica A; Jankovic D; Feng CG; Caspar P; Winkler-Pickett R; Trinchieri G; Sher A. 2007. TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-{gamma} production. J Exp Med 204(11):2591-602. [PubMed: 17923502]  [MGI Ref ID J:126112]

Gomes MS; Sousa Fernandes S; Cordeiro JV; Silva Gomes S; Vieira A; Appelberg R. 2008. Engagement of Toll-like receptor 2 in mouse macrophages infected with Mycobacterium avium induces non-oxidative and TNF-independent anti-mycobacterial activity. Eur J Immunol 38(8):2180-9. [PubMed: 18624355]  [MGI Ref ID J:138559]

Gondek DC; Roan NR; Starnbach MN. 2009. T cell responses in the absence of IFN-gamma exacerbate uterine infection with Chlamydia trachomatis. J Immunol 183(2):1313-9. [PubMed: 19561106]  [MGI Ref ID J:151656]

Gorham JD; Lin JT; Sung JL; Rudner LA; French MA. 2001. Genetic regulation of autoimmune disease: balb/c background tgf-beta1-deficient mice develop necroinflammatory ifn-gamma-dependent hepatitis. J Immunol 166(10):6413-22. [PubMed: 11342667]  [MGI Ref ID J:69346]

Gourzi P; Leonova T; Papavasiliou FN. 2007. Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB. J Exp Med 204(2):259-65. [PubMed: 17242162]  [MGI Ref ID J:125375]

Grabie N; Gotsman I; DaCosta R; Pang H; Stavrakis G; Butte MJ; Keir ME; Freeman GJ; Sharpe AH; Lichtman AH. 2007. Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell mediated injury in the heart. Circulation 116(18):2062-71. [PubMed: 17938288]  [MGI Ref ID J:142996]

Graham MB; Dalton DK; Giltinan D; Braciale VL; Stewart TA; Braciale TJ. 1993. Response to influenza infection in mice with a targeted disruption in the interferon gamma gene. J Exp Med 178(5):1725-32. [PubMed: 8228818]  [MGI Ref ID J:110721]

Gramaglia I; Sahlin H; Nolan JP; Frangos JA; Intaglietta M; van der Heyde HC. 2005. Cell- rather than antibody-mediated immunity leads to the development of profound thrombocytopenia during experimental Plasmodium berghei malaria. J Immunol 175(11):7699-707. [PubMed: 16301680]  [MGI Ref ID J:122163]

Gray BM; Fontaine CA; Poe SA; Eaton KA. 2013. Complex T Cell Interactions Contribute to Helicobacter pylori Gastritis in Mice. Infect Immun 81(3):740-52. [PubMed: 23264048]  [MGI Ref ID J:193044]

Gregg RK; Nichols L; Chen Y; Lu B; Engelhard VH. 2010. Mechanisms of spatial and temporal development of autoimmune vitiligo in tyrosinase-specific TCR transgenic mice. J Immunol 184(4):1909-17. [PubMed: 20083666]  [MGI Ref ID J:159480]

Gu T; Rowswell-Turner RB; Kilinc MO; Egilmez NK. 2010. Central role of IFNgamma-indoleamine 2,3-dioxygenase axis in regulation of interleukin-12-mediated antitumor immunity. Cancer Res 70(1):129-38. [PubMed: 20028855]  [MGI Ref ID J:155738]

Guarda G; Braun M; Staehli F; Tardivel A; Mattmann C; Forster I; Farlik M; Decker T; Du Pasquier RA; Romero P; Tschopp J. 2011. Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 34(2):213-23. [PubMed: 21349431]  [MGI Ref ID J:168972]

Gupta M; Greer P; Mahanty S; Shieh WJ; Zaki SR; Ahmed R; Rollin PE. 2005. CD8-mediated protection against Ebola virus infection is perforin dependent. J Immunol 174(7):4198-202. [PubMed: 15778381]  [MGI Ref ID J:97965]

Halloran PF; Afrouzian M; Ramassar V; Urmson J; Zhu LF; Helms LM; Solez K; Kneteman NM. 2001. Interferon-gamma acts directly on rejecting renal allografts to prevent graft necrosis. Am J Pathol 158(1):215-26. [PubMed: 11141495]  [MGI Ref ID J:68439]

Halloran PF; Miller LW; Urmson J; Ramassar V; Zhu LF; Kneteman NM; Solez K; Afrouzian M. 2001. IFN-gamma alters the pathology of graft rejection: protection from early necrosis. J Immunol 166(12):7072-81. [PubMed: 11390451]  [MGI Ref ID J:123807]

Hamadien M; Lycke N; Bakhiet M. 1999. Induction of the trypanosome lymphocyte-triggering factor (TLTF) and neutralizing antibodies to the TLTF in experimental african trypanosomiasis. Immunology 96(4):606-11. [PubMed: 10233748]  [MGI Ref ID J:110523]

Han YL; Li YL; Jia LX; Cheng JZ; Qi YF; Zhang HJ; Du J. 2012. Reciprocal interaction between macrophages and T cells stimulates IFN-gamma and MCP-1 production in Ang II-induced cardiac inflammation and fibrosis. PLoS One 7(5):e35506. [PubMed: 22567105]  [MGI Ref ID J:187265]

Hanada T; Kobayashi T; Chinen T; Saeki K; Takaki H; Koga K; Minoda Y; Sanada T; Yoshioka T; Mimata H; Kato S; Yoshimura A. 2006. IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. J Exp Med 203(6):1391-7. [PubMed: 16717119]  [MGI Ref ID J:115075]

Hancock WW; Szaba FM; Berggren KN; Parent MA; Mullarky IK; Pearl J; Cooper AM; Ely KH; Woodland DL; Kim IJ; Blackman MA; Johnson LL; Smiley ST. 2004. Intact type 1 immunity and immune-associated coagulative responses in mice lacking IFN gamma-inducible fibrinogen-like protein 2. Proc Natl Acad Sci U S A 101(9):3005-10. [PubMed: 14976252]  [MGI Ref ID J:88648]

Hao S; Yuan J; Xu S; Munegowda MA; Deng Y; Gordon J; Xing Z; Xiang J. 2008. Antigen specificity acquisition of adoptive CD4+ regulatory T cells via acquired peptide-MHC class I complexes. J Immunol 181(4):2428-37. [PubMed: 18684933]  [MGI Ref ID J:140189]

Hardison SE; Wozniak KL; Kolls JK; Wormley FL Jr. 2010. Interleukin-17 Is Not Required for Classical Macrophage Activation in a Pulmonary Mouse Model of Cryptococcus neoformans Infection. Infect Immun 78(12):5341-51. [PubMed: 20921149]  [MGI Ref ID J:166071]

Haring JS; Badovinac VP; Olson MR; Varga SM; Harty JT. 2005. In vivo generation of pathogen-specific Th1 cells in the absence of the IFN-gamma receptor. J Immunol 175(5):3117-22. [PubMed: 16116201]  [MGI Ref ID J:113254]

Haring JS; Harty JT. 2006. Aberrant contraction of antigen-specific CD4 T cells after infection in the absence of gamma interferon or its receptor. Infect Immun 74(11):6252-63. [PubMed: 16966404]  [MGI Ref ID J:113551]

Harrington LE; Hatton RD; Mangan PR; Turner H; Murphy TL; Murphy KM; Weaver CT. 2005. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6(11):1123-32. [PubMed: 16200070]  [MGI Ref ID J:112601]

Harris DP; Goodrich S; Gerth AJ; Peng SL; Lund FE. 2005. Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor. J Immunol 174(11):6781-90. [PubMed: 15905519]  [MGI Ref ID J:99038]

Harris TH; Mansfield JM; Paulnock DM. 2007. CpG oligodeoxynucleotide treatment enhances innate resistance and acquired immunity to African trypanosomes. Infect Immun 75(5):2366-73. [PubMed: 17339353]  [MGI Ref ID J:121887]

Hart G; Avin-Wittenberg T; Shachar I. 2008. IL-15 regulates immature B-cell homing in an Ly49D-, IL-12 , and IL-18 dependent manner. Blood 111(1):50-9. [PubMed: 17901247]  [MGI Ref ID J:130042]

Hart G; Flaishon L; Becker-Herman S; Shachar I. 2003. Ly49D receptor expressed on immature B cells regulates their IFN-gamma secretion, actin polymerization, and homing. J Immunol 171(9):4630-8. [PubMed: 14568937]  [MGI Ref ID J:119214]

Hart G; Flaishon L; Shachar I. 2007. IL-12 and IL-18 down-regulate B cell migration in an Ly49D-dependent manner. Eur J Immunol 37(7):1996-2007. [PubMed: 17557376]  [MGI Ref ID J:123474]

Harty JT; Bevan MJ. 1995. Specific immunity to Listeria monocytogenes in the absence of IFN gamma. Immunity 3(1):109-17. [PubMed: 7621071]  [MGI Ref ID J:83180]

Hashimoto M; Ayada T; Kinjyo I; Hiwatashi K; Yoshida H; Okada Y; Kobayashi T; Yoshimura A. 2009. Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation. Cancer Sci 100(4):730-6. [PubMed: 19469017]  [MGI Ref ID J:150670]

Hashimoto M; Hiwatashi K; Ichiyama K; Morita R; Sekiya T; Kimura A; Sugiyama Y; Sibata T; Kuroda K; Takahashi R; Yoshimura A. 2011. SOCS1 regulates type I/type II NKT cell balance by regulating IFN{gamma} signaling. Int Immunol 23(3):165-76. [PubMed: 21393632]  [MGI Ref ID J:169668]

Hata H; Sakaguchi N; Yoshitomi H; Iwakura Y; Sekikawa K; Azuma Y; Kanai C; Moriizumi E; Nomura T; Nakamura T; Sakaguchi S. 2004. Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. J Clin Invest 114(4):582-8. [PubMed: 15314695]  [MGI Ref ID J:92002]

Hausmann J; Pagenstecher A; Baur K; Richter K; Rziha HJ; Staeheli P. 2005. CD8 T cells require gamma interferon to clear borna disease virus from the brain and prevent immune system-mediated neuronal damage. J Virol 79(21):13509-18. [PubMed: 16227271]  [MGI Ref ID J:102183]

Havarinasab S; Haggqvist B; Bjorn E; Pollard KM; Hultman P. 2005. Immunosuppressive and autoimmune effects of thimerosal in mice. Toxicol Appl Pharmacol 204(2):109-21. [PubMed: 15808517]  [MGI Ref ID J:97345]

Havarinasab S; Pollard KM; Hultman P. 2009. Gold- and silver-induced murine autoimmunity--requirement for cytokines and CD28 in murine heavy metal-induced autoimmunity. Clin Exp Immunol 155(3):567-76. [PubMed: 19077085]  [MGI Ref ID J:146057]

Hayward AR; Chmura K; Cosyns M. 2000. Interferon-gamma is required for innate immunity to Cryptosporidium parvum in mice. J Infect Dis 182(3):1001-4. [PubMed: 10950807]  [MGI Ref ID J:125986]

He W; Hao J; Dong S; Gao Y; Tao J; Chi H; Flavell R; O'Brien RL; Born WK; Craft J; Han J; Wang P; Zhao L; Wu J; Yin Z. 2010. Naturally activated Vgamma4 gammadelta T cells play a protective role in tumor immunity through expression of eomesodermin. J Immunol 185(1):126-33. [PubMed: 20525896]  [MGI Ref ID J:161612]

Heath L; Chrisp C; Huffnagle G; LeGendre M; Osawa Y; Hurley M; Engleberg C; Fantone J; Brieland J. 1996. Effector mechanisms responsible for gamma interferon-mediated host resistance to Legionella pneumophila lung infection: the role of endogenous nitric oxide differs in susceptible and resistant murine hosts. Infect Immun 64(12):5151-60. [PubMed: 8945559]  [MGI Ref ID J:36862]

Hegazy AN; Peine M; Helmstetter C; Panse I; Frohlich A; Bergthaler A; Flatz L; Pinschewer DD; Radbruch A; Lohning M. 2010. Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions. Immunity 32(1):116-28. [PubMed: 20079668]  [MGI Ref ID J:157702]

Helmby H. 2009. Gastrointestinal nematode infection exacerbates malaria-induced liver pathology. J Immunol 182(9):5663-71. [PubMed: 19380813]  [MGI Ref ID J:147710]

Helmby H; Grencis RK. 2002. IL-18 regulates intestinal mastocytosis and Th2 cytokine production independently of IFN-gamma during Trichinella spiralis infection. J Immunol 169(5):2553-60. [PubMed: 12193725]  [MGI Ref ID J:120688]

Henke PK; Pearce CG; Moaveni DM; Moore AJ; Lynch EM; Longo C; Varma M; Dewyer NA; Deatrick KB; Upchurch GR Jr; Wakefield TW; Hogaboam C; Kunkel SL. 2006. Targeted deletion of CCR2 impairs deep vein thombosis resolution in a mouse model. J Immunol 177(5):3388-97. [PubMed: 16920980]  [MGI Ref ID J:139537]

Hertz CJ; Filutowicz H; Mansfield JM. 1998. Resistance to the African trypanosomes is IFN-gamma dependent. J Immunol 161(12):6775-83. [PubMed: 9862708]  [MGI Ref ID J:115095]

Hertz CJ; Mansfield JM. 1999. IFN-gamma-dependent nitric oxide production is not linked to resistance in experimental African trypanosomiasis. Cell Immunol 192(1):24-32. [PubMed: 10066343]  [MGI Ref ID J:114251]

Hinrichs CS; Borman ZA; Cassard L; Gattinoni L; Spolski R; Yu Z; Sanchez-Perez L; Muranski P; Kern SJ; Logun C; Palmer DC; Ji Y; Reger RN; Leonard WJ; Danner RL; Rosenberg SA; Restifo NP. 2009. Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity. Proc Natl Acad Sci U S A 106(41):17469-74. [PubMed: 19805141]  [MGI Ref ID J:153682]

Hofer M; Hausmann J; Staeheli P; Pagenstecher A. 2004. Cerebral expression of interleukin-12 induces neurological disease via differential pathways and recruits antigen-specific T cells in virus-infected mice. Am J Pathol 165(3):949-58. [PubMed: 15331418]  [MGI Ref ID J:92418]

Hoff DR; Ryan GJ; Driver ER; Ssemakulu CC; De Groote MA; Basaraba RJ; Lenaerts AJ. 2011. Location of intra- and extracellular M. tuberculosis populations in lungs of mice and guinea pigs during disease progression and after drug treatment. PLoS One 6(3):e17550. [PubMed: 21445321]  [MGI Ref ID J:171674]

Hofstetter HH; Sewell DL; Liu F; Sandor M; Forsthuber T; Lehmann PV; Fabry Z. 2003. Autoreactive T cells promote post-traumatic healing in the central nervous system. J Neuroimmunol 134(1-2):25-34. [PubMed: 12507769]  [MGI Ref ID J:119263]

Hofstra CL; Van Ark I; Hofman G; Nijkamp FP; Jardieu PM; Van Oosterhout AJ. 1998. Differential effects of endogenous and exogenous interferon-gamma on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma. Am J Respir Cell Mol Biol 19(5):826-35. [PubMed: 9806748]  [MGI Ref ID J:114213]

Hollenbaugh JA; Reome J; Dobrzanski M; Dutton RW. 2004. The rate of the CD8-dependent initial reduction in tumor volume is not limited by contact-dependent perforin, Fas ligand, or TNF-mediated cytolysis. J Immunol 173(3):1738-43. [PubMed: 15265903]  [MGI Ref ID J:92134]

Hong F; Jaruga B; Kim WH; Radaeva S; El-Assal ON; Tian Z; Nguyen VA; Gao B. 2002. Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS. J Clin Invest 110(10):1503-13. [PubMed: 12438448]  [MGI Ref ID J:80183]

Hong Y; Peng Y; Xiao H; Mi M; Munn D; He Y. 2012. Immunoglobulin Fc fragment tagging allows strong activation of endogenous CD4 T cells to reshape the tumor milieu and enhance the antitumor effect of lentivector immunization. J Immunol 188(10):4819-27. [PubMed: 22504640]  [MGI Ref ID J:188675]

Horino J; Fujimoto M; Terabe F; Serada S; Takahashi T; Soma Y; Tanaka K; Chinen T; Yoshimura A; Nomura S; Kawase I; Hayashi N; Kishimoto T; Naka T. 2008. Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice. Int Immunol 20(6):753-62. [PubMed: 18381351]  [MGI Ref ID J:136172]

Horwitz MS; Krahl T; Fine C; Lee J; Sarvetnick N. 1999. Protection from lethal coxsackievirus-induced pancreatitis by expression of gamma interferon. J Virol 73(3):1756-66. [PubMed: 9971752]  [MGI Ref ID J:120473]

Hoshino T; Kato S; Oka N; Imaoka H; Kinoshita T; Takei S; Kitasato Y; Kawayama T; Imaizumi T; Yamada K; Young HA; Aizawa H. 2007. Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13. Am J Respir Crit Care Med 176(1):49-62. [PubMed: 17400729]  [MGI Ref ID J:147547]

Hoshino T; Winkler-Pickett RT; Mason AT; Ortaldo JR; Young HA. 1999. IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-gamma. J Immunol 162(1):51-9. [PubMed: 9886369]  [MGI Ref ID J:112424]

Houpt ER; Glembocki DJ; Obrig TG; Moskaluk CA; Lockhart LA; Wright RL; Seaner RM; Keepers TR; Wilkins TD; Petri WA Jr. 2002. The mouse model of amebic colitis reveals mouse strain susceptibility to infection and exacerbation of disease by CD4+ T cells. J Immunol 169(8):4496-503. [PubMed: 12370386]  [MGI Ref ID J:120012]

Houri-Haddad Y; Soskolne WA; Shai E; Palmon A; Shapira L. 2002. Interferon-gamma deficiency attenuates local P. gingivalis-induced inflammation. J Dent Res 81(6):395-8. [PubMed: 12097431]  [MGI Ref ID J:105950]

Hu J; Sahu N; Walsh E; August A. 2007. Memory phenotype CD8(+) T cells with innate function selectively develop in the absence of active Itk. Eur J Immunol 37(10):2892-9. [PubMed: 17724684]  [MGI Ref ID J:125268]

Huang G; Wang Y; Vogel P; Kanneganti TD; Otsu K; Chi H. 2012. Signaling via the kinase p38alpha programs dendritic cells to drive TH17 differentiation and autoimmune inflammation. Nat Immunol 13(2):152-61. [PubMed: 22231518]  [MGI Ref ID J:181211]

Huang X; McClellan SA; Barrett RP; Hazlett LD. 2002. IL-18 contributes to host resistance against infection with Pseudomonas aeruginosa through induction of IFN-gamma production. J Immunol 168(11):5756-63. [PubMed: 12023376]  [MGI Ref ID J:123799]

Hultgren B; Huang X; Dybdal N; Stewart TA. 1996. Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice. Diabetes 45(6):812-7. [PubMed: 8635658]  [MGI Ref ID J:33427]

Hung K; Hayashi R; Lafond-Walker A; Lowenstein C; Pardoll D; Levitsky H. 1998. The central role of CD4(+) T cells in the antitumor immune response. J Exp Med 188(12):2357-68. [PubMed: 9858522]  [MGI Ref ID J:51677]

Hwang SJ; Kim S; Park WS; Chung DH. 2006. IL-4-secreting NKT cells prevent hypersensitivity pneumonitis by suppressing IFN-gamma-producing neutrophils. J Immunol 177(8):5258-68. [PubMed: 17015711]  [MGI Ref ID J:139446]

Hyland NP; Sjoberg F; Tough IR; Herzog H; Cox HM. 2003. Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues. Br J Pharmacol 139(4):863-71. [PubMed: 12813010]  [MGI Ref ID J:103044]

Iijima H; Neurath MF; Nagaishi T; Glickman JN; Nieuwenhuis EE; Nakajima A; Chen D; Fuss IJ; Utku N; Lewicki DN; Becker C; Gallagher TM; Holmes KV; Blumberg RS. 2004. Specific regulation of T helper cell 1-mediated murine colitis by CEACAM1. J Exp Med 199(4):471-82. [PubMed: 14970176]  [MGI Ref ID J:90476]

Ilangumaran S; Ramanathan S; La Rose J; Poussier P; Rottapel R. 2003. Suppressor of cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44(high) memory T lymphocytes. J Immunol 171(5):2435-45. [PubMed: 12928391]  [MGI Ref ID J:85085]

Ilangumaran S; Ramanathan S; Ning T; La Rose J; Reinhart B; Poussier P; Rottapel R. 2003. Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes. Blood 102(12):4115-22. [PubMed: 12907450]  [MGI Ref ID J:86680]

Imai T; Shen J; Chou B; Duan X; Tu L; Tetsutani K; Moriya C; Ishida H; Hamano S; Shimokawa C; Hisaeda H; Himeno K. 2010. Involvement of CD8+ T cells in protective immunity against murine blood-stage infection with Plasmodium yoelii 17XL strain. Eur J Immunol 40(4):1053-61. [PubMed: 20101613]  [MGI Ref ID J:159116]

Irmler IM; Gajda M; Brauer R. 2007. Exacerbation of antigen-induced arthritis in IFN-gamma-deficient mice as a result of unrestricted IL-17 response. J Immunol 179(9):6228-36. [PubMed: 17947698]  [MGI Ref ID J:152989]

Ishigame H; Zenewicz LA; Sanjabi S; Licona-Limon P; Nakayama M; Leonard WJ; Flavell RA. 2013. Excessive Th1 responses due to the absence of TGF-beta signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis. Proc Natl Acad Sci U S A 110(17):6961-6. [PubMed: 23569233]  [MGI Ref ID J:196160]

Ishii KJ; Ito S; Tamura T; Hemmi H; Conover J; Ozato K; Akira S; Klinman DM. 2005. CpG-activated Thy1.2+ dendritic cells protect against lethal Listeria monocytogenes infection. Eur J Immunol 35(8):2397-405. [PubMed: 16047338]  [MGI Ref ID J:100431]

Ishiwata K; Watanabe N; Guo M; Tomihara K; Brumlik MJ; Yagita H; Pardoll D; Chen L; Shin T. 2010. Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis. J Immunol 184(4):2086-94. [PubMed: 20065112]  [MGI Ref ID J:159489]

Ito T; Nishiyama C; Nakano N; Nishiyama M; Usui Y; Takeda K; Kanada S; Fukuyama K; Akiba H; Tokura T; Hara M; Tsuboi R; Ogawa H; Okumura K. 2009. Roles of PU.1 in monocyte- and mast cell-specific gene regulation: PU.1 transactivates CIITA pIV in cooperation with IFN-gamma. Int Immunol 21(7):803-16. [PubMed: 19502584]  [MGI Ref ID J:150283]

Jacobs JP; Wu HJ; Benoist C; Mathis D. 2009. IL-17-producing T cells can augment autoantibody-induced arthritis. Proc Natl Acad Sci U S A :. [PubMed: 19955422]  [MGI Ref ID J:155519]

Jamieson E; Chong MM; Steinberg GR; Jovanovska V; Fam BC; Bullen DV; Chen Y; Kemp BE; Proietto J; Kay TW; Andrikopoulos S. 2005. Socs1 deficiency enhances hepatic insulin signaling. J Biol Chem 280(36):31516-21. [PubMed: 15983045]  [MGI Ref ID J:101166]

Jankovic D; Kullberg MC; Hieny S; Caspar P; Collazo CM; Sher A. 2002. In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting. Immunity 16(3):429-39. [PubMed: 11911827]  [MGI Ref ID J:113516]

Jaruga B; Hong F; Kim WH; Gao B. 2004. IFN-gamma/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role of IRF-1. Am J Physiol Gastrointest Liver Physiol 287(5):G1044-52. [PubMed: 15246962]  [MGI Ref ID J:96187]

Jasperson LK; Bucher C; Panoskaltsis-Mortari A; Mellor AL; Munn DH; Blazar BR. 2009. Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality. Blood 114(24):5062-70. [PubMed: 19828695]  [MGI Ref ID J:155467]

Jegerlehner A; Maurer P; Bessa J; Hinton HJ; Kopf M; Bachmann MF. 2007. TLR9 signaling in B cells determines class switch recombination to IgG2a. J Immunol 178(4):2415-20. [PubMed: 17277148]  [MGI Ref ID J:143978]

Jelinsky SA; Miyashiro JS; Saraf KA; Tunkey C; Reddy P; Newcombe J; Oestreicher JL; Brown E; Trepicchio WL; Leonard JP; Marusic S. 2005. Exploiting genotypic differences to identify genes important for EAE development. J Neurol Sci 239(1):81-93. [PubMed: 16214174]  [MGI Ref ID J:106390]

Jenner RG; Townsend MJ; Jackson I; Sun K; Bouwman RD; Young RA; Glimcher LH; Lord GM. 2009. The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proc Natl Acad Sci U S A 106(42):17876-81. [PubMed: 19805038]  [MGI Ref ID J:153703]

Jeon SB; Yoon HJ; Chang CY; Koh HS; Jeon SH; Park EJ. 2010. Galectin-3 Exerts Cytokine-Like Regulatory Actions through the JAK-STAT Pathway. J Immunol 185(11):7037-46. [PubMed: 20980634]  [MGI Ref ID J:166149]

Jiang Q; Weiss JM; Back T; Chan T; Ortaldo JR; Guichard S; Wiltrout RH. 2011. mTOR Kinase Inhibitor AZD8055 Enhances the Immunotherapeutic Activity of an Agonist CD40 Antibody in Cancer Treatment. Cancer Res 71(12):4074-84. [PubMed: 21540234]  [MGI Ref ID J:173408]

Jiang X; Clark RA; Liu L; Wagers AJ; Fuhlbrigge RC; Kupper TS. 2012. Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity. Nature 483(7388):227-31. [PubMed: 22388819]  [MGI Ref ID J:181682]

Jin JO; Yu Q. 2013. Systemic administration of TLR3 agonist induces IL-7 expression and IL-7-dependent CXCR3 ligand production in the lung. J Leukoc Biol 93(3):413-25. [PubMed: 23271706]  [MGI Ref ID J:198081]

Jinushi M; Nakazaki Y; Dougan M; Carrasco DR; Mihm M; Dranoff G. 2007. MFG-E8-mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF. J Clin Invest 117(7):1902-13. [PubMed: 17557120]  [MGI Ref ID J:124038]

Johnson LL; Sayles PC. 1995. Strong cytolytic activity of natural killer cells is neither necessary nor sufficient for preimmune resistance to Toxoplasma gondii infection. Nat Immun 14(4):209-15. [PubMed: 8696010]  [MGI Ref ID J:113057]

Jones TG; Finkelman FD; Austen KF; Gurish MF. 2010. T regulatory cells control antigen-induced recruitment of mast cell progenitors to the lungs of C57BL/6 mice. J Immunol 185(3):1804-11. [PubMed: 20601599]  [MGI Ref ID J:162451]

Jones TG; Hallgren J; Humbles A; Burwell T; Finkelman FD; Alcaide P; Austen KF; Gurish MF. 2009. Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells. J Immunol 183(8):5251-60. [PubMed: 19783672]  [MGI Ref ID J:153832]

Joosten LA; van De Loo FA; Lubberts E; Helsen MM; Netea MG; van Der Meer JW; Dinarello CA; van Den Berg WB. 2000. An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis. J Immunol 165(11):6553-8. [PubMed: 11086098]  [MGI Ref ID J:127165]

Jouanguy E; Doffinger R; Dupuis S; Pallier A; Altare F; Casanova JL. 1999. IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men. Curr Opin Immunol 11(3):346-51. [PubMed: 10375558]  [MGI Ref ID J:55697]

Junqueira-Kipnis AP; Basaraba RJ; Gruppo V; Palanisamy G; Turner OC; Hsu T; Jacobs WR Jr; Fulton SA; Reba SM; Boom WH; Orme IM. 2006. Mycobacteria lacking the RD1 region do not induce necrosis in the lungs of mice lacking interferon-gamma. Immunology 119(2):224-31. [PubMed: 17005003]  [MGI Ref ID J:118520]

Jupelli M; Guentzel MN; Meier PA; Zhong G; Murthy AK; Arulanandam BP. 2008. Endogenous IFN-{gamma} Production Is Induced and Required for Protective Immunity against Pulmonary Chlamydial Infection in Neonatal Mice. J Immunol 180(6):4148-55. [PubMed: 18322226]  [MGI Ref ID J:132958]

Kamanaka M; Huber S; Zenewicz LA; Gagliani N; Rathinam C; O'Connor W Jr; Wan YY; Nakae S; Iwakura Y; Hao L; Flavell RA. 2011. Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology. J Exp Med 208(5):1027-40. [PubMed: 21518800]  [MGI Ref ID J:177300]

Kammertoens T; Willebrand R; Erdmann B; Li L; Li Y; Engels B; Uckert W; Blankenstein T. 2005. CY15, a malignant histiocytic tumor that is phenotypically similar to immature dendritic cells. Cancer Res 65(7):2560-4. [PubMed: 15805249]  [MGI Ref ID J:97347]

Kane M; Case LK; Wang C; Yurkovetskiy L; Dikiy S; Golovkina TV. 2011. Innate Immune Sensing of Retroviral Infection via Toll-like Receptor 7 Occurs upon Viral Entry. Immunity 35(1):135-45. [PubMed: 21723157]  [MGI Ref ID J:174379]

Kang MJ; Lee CG; Lee JY; Dela Cruz CS; Chen ZJ; Enelow R; Elias JA. 2008. Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice. J Clin Invest 118(8):2771-84. [PubMed: 18654661]  [MGI Ref ID J:140864]

Kanhere A; Hertweck A; Bhatia U; Gokmen MR; Perucha E; Jackson I; Lord GM; Jenner RG. 2012. T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements. Nat Commun 3:1268. [PubMed: 23232398]  [MGI Ref ID J:205611]

Kania G; Siegert S; Behnke S; Prados-Rosales R; Casadevall A; Luscher TF; Luther SA; Kopf M; Eriksson U; Blyszczuk P. 2013. Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis. Circulation 127(23):2285-94. [PubMed: 23671208]  [MGI Ref ID J:211390]

Kanistanon D; Powell DA; Hajjar AM; Pelletier MR; Cohen IE; Way SS; Skerrett SJ; Wang X; Raetz CR; Ernst RK. 2012. Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses. Infect Immun 80(3):943-51. [PubMed: 22215738]  [MGI Ref ID J:182434]

Karachunski PI; Ostlie NS; Monfardini C; Conti-Fine BM. 2000. Absence of IFN-gamma or IL-12 has different effects on experimental myasthenia gravis in C57BL/6 mice. J Immunol 164(10):5236-44. [PubMed: 10799884]  [MGI Ref ID J:62120]

Karpuzoglu E; Fenaux JB; Phillips RA; Lengi AJ; Elvinger F; Ansar Ahmed S. 2006. Estrogen up-regulates inducible nitric oxide synthase, nitric oxide, and cyclooxygenase-2 in splenocytes activated with T cell stimulants: role of interferon-gamma. Endocrinology 147(2):662-71. [PubMed: 16293660]  [MGI Ref ID J:129444]

Kastenmuller W; Brandes M; Wang Z; Herz J; Egen JG; Germain RN. 2013. Peripheral Prepositioning and Local CXCL9 Chemokine-Mediated Guidance Orchestrate Rapid Memory CD8(+) T Cell Responses in the Lymph Node. Immunity 38(3):502-13. [PubMed: 23352234]  [MGI Ref ID J:194479]

Kataru RP; Kim H; Jang C; Choi DK; Koh BI; Kim M; Gollamudi S; Kim YK; Lee SH; Koh GY. 2011. T lymphocytes negatively regulate lymph node lymphatic vessel formation. Immunity 34(1):96-107. [PubMed: 21256057]  [MGI Ref ID J:168062]

Kawamura T; Takeda K; Kaneda H; Matsumoto H; Hayakawa Y; Raulet DH; Ikarashi Y; Kronenberg M; Yagita H; Kinoshita K; Abo T; Okumura K; Smyth MJ. 2009. NKG2A inhibits invariant NKT cell activation in hepatic injury. J Immunol 182(1):250-8. [PubMed: 19109156]  [MGI Ref ID J:143037]

Kawano M; Nakayama M; Aoshima Y; Nakamura K; Ono M; Nishiya T; Nakamura S; Takeda Y; Dobashi A; Takahashi A; Endo M; Ito A; Ueda K; Sato N; Higuchi S; Kondo T; Hashimoto S; Watanabe M; Watanabe M; Takahashi T; Sasaki K; Nakamura M; Sasazuki T; Narushima T; Suzuki R; Ogasawara K. 2014. NKG2D(+) IFN-gamma(+) CD8(+) T cells are responsible for palladium allergy. PLoS One 9(2):e86810. [PubMed: 24533050]  [MGI Ref ID J:212941]

Kawata K; Tsuda M; Yang GX; Zhang W; Tanaka H; Tsuneyama K; Leung P; He XS; Knechtle S; Ansari AA; Coppel RL; Gershwin ME. 2013. Identification of potential cytokine pathways for therapeutic intervention in murine primary biliary cirrhosis. PLoS One 8(9):e74225. [PubMed: 24040208]  [MGI Ref ID J:206046]

Kayes TD; Braley-Mullen H. 2013. Culture promotes transfer of thyroid epithelial cell hyperplasia and proliferation by reducing regulatory T cell numbers. Cell Immunol 285(1-2):84-91. [PubMed: 24135055]  [MGI Ref ID J:206056]

Kellermann SA; McEvoy LM. 2001. The Peyer's patch microenvironment suppresses T cell responses to chemokines and other stimuli. J Immunol 167(2):682-90. [PubMed: 11441071]  [MGI Ref ID J:120507]

Kerkar SP; Goldszmid RS; Muranski P; Chinnasamy D; Yu Z; Reger RN; Leonardi AJ; Morgan RA; Wang E; Marincola FM; Trinchieri G; Rosenberg SA; Restifo NP. 2011. IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors. J Clin Invest 121(12):4746-57. [PubMed: 22056381]  [MGI Ref ID J:184027]

Khader SA; Bell GK; Pearl JE; Fountain JJ; Rangel-Moreno J; Cilley GE; Shen F; Eaton SM; Gaffen SL; Swain SL; Locksley RM; Haynes L; Randall TD; Cooper AM. 2007. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol 8(4):369-77. [PubMed: 17351619]  [MGI Ref ID J:120806]

Khan AA; Priya S; Saha B. 2009. IL-2 regulates SEB induced toxic shock syndrome in BALB/c mice. PLoS One 4(12):e8473. [PubMed: 20041187]  [MGI Ref ID J:155944]

Khan S; van den Broek M; Schwarz K; de Giuli R; Diener PA; Groettrup M. 2001. Immunoproteasomes largely replace constitutive proteasomes during an antiviral and antibacterial immune response in the liver. J Immunol 167(12):6859-68. [PubMed: 11739503]  [MGI Ref ID J:73089]

Kim G; Turovskaya O; Levin M; Byrne FR; Whoriskey JS; McCabe JG; Kronenberg M. 2008. Spontaneous colitis occurrence in transgenic mice with altered B7-mediated costimulation. J Immunol 181(8):5278-88. [PubMed: 18832683]  [MGI Ref ID J:140772]

Kim HY; Kim HJ; Min HS; Kim S; Park WS; Park SH; Chung DH. 2005. NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor beta1 production. J Exp Med 201(1):41-7. [PubMed: 15630137]  [MGI Ref ID J:95287]

Kim JH; Chung DH. 2011. CD1d-restricted IFN-gamma-secreting NKT cells promote immune complex-induced acute lung injury by regulating macrophage-inflammatory protein-1alpha production and activation of macrophages and dendritic cells. J Immunol 186(3):1432-41. [PubMed: 21191075]  [MGI Ref ID J:168903]

Kim JH; Kim HY; Kim S; Chung JH; Park WS; Chung DH. 2005. Natural Killer T (NKT) Cells Attenuate Bleomycin-Induced Pulmonary Fibrosis by Producing Interferon-{gamma}. Am J Pathol 167(5):1231-41. [PubMed: 16251408]  [MGI Ref ID J:102402]

Kim YK; Oh SY; Jeon SG; Park HW; Lee SY; Chun EY; Bang B; Lee HS; Oh MH; Kim YS; Kim JH; Gho YS; Cho SH; Min KU; Kim YY; Zhu Z. 2007. Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma. J Immunol 178(8):5375-82. [PubMed: 17404323]  [MGI Ref ID J:145264]

Kimura MY; Pobezinsky LA; Guinter TI; Thomas J; Adams A; Park JH; Tai X; Singer A. 2013. IL-7 signaling must be intermittent, not continuous, during CD8(+) T cell homeostasis to promote cell survival instead of cell death. Nat Immunol 14(2):143-51. [PubMed: 23242416]  [MGI Ref ID J:192537]

King VL; Lin AY; Kristo F; Anderson TJ; Ahluwalia N; Hardy GJ; Owens AP 3rd; Howatt DA; Shen D; Tager AM; Luster AD; Daugherty A; Gerszten RE. 2009. Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture. Circulation 119(3):426-35. [PubMed: 19139386]  [MGI Ref ID J:166204]

Kinjyo I; Hanada T; Inagaki-Ohara K; Mori H; Aki D; Ohishi M; Yoshida H; Kubo M; Yoshimura A. 2002. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 17(5):583-91. [PubMed: 12433365]  [MGI Ref ID J:125159]

Kirimanjeswara GS; Golden JM; Bakshi CS; Metzger DW. 2007. Prophylactic and therapeutic use of antibodies for protection against respiratory infection with Francisella tularensis. J Immunol 179(1):532-9. [PubMed: 17579074]  [MGI Ref ID J:149409]

Kirksey MA; Tischler AD; Simeone R; Hisert KB; Uplekar S; Guilhot C; McKinney JD. 2011. Spontaneous Phthiocerol Dimycocerosate-Deficient Variants of Mycobacterium tuberculosis Are Susceptible to Gamma Interferon-Mediated Immunity. Infect Immun 79(7):2829-38. [PubMed: 21576344]  [MGI Ref ID J:173476]

Kish DD; Li X; Fairchild RL. 2009. CD8 T cells producing IL-17 and IFN-gamma initiate the innate immune response required for responses to antigen skin challenge. J Immunol 182(10):5949-59. [PubMed: 19414746]  [MGI Ref ID J:148247]

Kitching AR; Turner AL; Semple T; Li M; Edgtton KL; Wilson GR; Timoshanko JR; Hudson BG; Holdsworth SR. 2004. Experimental autoimmune anti-glomerular basement membrane glomerulonephritis: a protective role for IFN-gamma. J Am Soc Nephrol 15(7):1764-74. [PubMed: 15213264]  [MGI Ref ID J:132564]

Klebanoff CA; Yu Z; Hwang LN; Palmer DC; Gattinoni L; Restifo NP. 2009. Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination. Blood 114(9):1776-83. [PubMed: 19561320]  [MGI Ref ID J:152256]

Kleinman ME; Yamada K; Takeda A; Chandrasekaran V; Nozaki M; Baffi JZ; Albuquerque RJ; Yamasaki S; Itaya M; Pan Y; Appukuttan B; Gibbs D; Yang Z; Kariko K; Ambati BK; Wilgus TA; DiPietro LA; Sakurai E; Zhang K; Smith JR; Taylor EW; Ambati J. 2008. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature 452(7187):591-7. [PubMed: 18368052]  [MGI Ref ID J:133772]

Kleinschek MA; Owyang AM; Joyce-Shaikh B; Langrish CL; Chen Y; Gorman DM; Blumenschein WM; McClanahan T; Brombacher F; Hurst SD; Kastelein RA; Cua DJ. 2007. IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med 204(1):161-70. [PubMed: 17200411]  [MGI Ref ID J:125296]

Kleinschnitz C; Kraft P; Dreykluft A; Hagedorn I; Gobel K; Schuhmann MK; Langhauser F; Helluy X; Schwarz T; Bittner S; Mayer CT; Brede M; Varallyay C; Pham M; Bendszus M; Jakob P; Magnus T; Meuth SG; Iwakura Y; Zernecke A; Sparwasser T; Nieswandt B; Stoll G; Wiendl H. 2013. Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood 121(4):679-91. [PubMed: 23160472]  [MGI Ref ID J:194093]

Kline J; Zhang L; Battaglia L; Cohen KS; Gajewski TF. 2012. Cellular and molecular requirements for rejection of b16 melanoma in the setting of regulatory T cell depletion and homeostatic proliferation. J Immunol 188(6):2630-42. [PubMed: 22312128]  [MGI Ref ID J:181862]

Knight DA; Ngiow SF; Li M; Parmenter T; Mok S; Cass A; Haynes NM; Kinross K; Yagita H; Koya RC; Graeber TG; Ribas A; McArthur GA; Smyth MJ. 2013. Host immunity contributes to the anti-melanoma activity of BRAF inhibitors. J Clin Invest 123(3):1371-81. [PubMed: 23454771]  [MGI Ref ID J:196375]

Kobayashi T; Kawamura H; Kanda Y; Matsumoto H; Saito S; Takeda K; Kawamura T; Abo T. 2012. Natural killer T cells suppress zymosan A-mediated granuloma formation in the liver by modulating interferon-gamma and interleukin-10. Immunology 136(1):86-95. [PubMed: 22268994]  [MGI Ref ID J:184091]

Koch M; Witzenrath M; Reuter C; Herma M; Schutte H; Suttorp N; Collins H; Kaufmann SH. 2006. Role of local pulmonary IFN-gamma expression in murine allergic airway inflammation. Am J Respir Cell Mol Biol 35(2):211-9. [PubMed: 16543606]  [MGI Ref ID J:123674]

Koch MA; Thomas KR; Perdue NR; Smigiel KS; Srivastava S; Campbell DJ. 2012. T-bet(+) Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor beta2. Immunity 37(3):501-10. [PubMed: 22960221]  [MGI Ref ID J:187671]

Koenecke C; Lee CW; Thamm K; Fohse L; Schafferus M; Mittrucker HW; Floess S; Huehn J; Ganser A; Forster R; Prinz I. 2012. IFN-gamma production by allogeneic Foxp3+ regulatory T cells is essential for preventing experimental graft-versus-host disease. J Immunol 189(6):2890-6. [PubMed: 22869903]  [MGI Ref ID J:189843]

Kohlhapp FJ; Zloza A; O'Sullivan JA; Moore TV; Lacek AT; Jagoda MC; McCracken J; Cole DJ; Guevara-Patino JA. 2012. CD8(+) T cells sabotage their own memory potential through IFN-gamma-dependent modification of the IL-12/IL-15 receptor alpha axis on dendritic cells. J Immunol 188(8):3639-47. [PubMed: 22430740]  [MGI Ref ID J:184140]

Komiyama Y; Nakae S; Matsuki T; Nambu A; Ishigame H; Kakuta S; Sudo K; Iwakura Y. 2006. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol 177(1):566-73. [PubMed: 16785554]  [MGI Ref ID J:134438]

Kono DH; Balomenos D; Pearson DL; Park MS; Hildebrandt B; Hultman P; Pollard KM. 1998. The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-gamma and not Th1/Th2 imbalance. J Immunol 161(1):234-40. [PubMed: 9647229]  [MGI Ref ID J:119207]

Kontoyiannis D; Boulougouris G; Manoloukos M; Armaka M; Apostolaki M; Pizarro T; Kotlyarov A; Forster I; Flavell R; Gaestel M; Tsichlis P; Cominelli F; Kollias G. 2002. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med 196(12):1563-74. [PubMed: 12486099]  [MGI Ref ID J:108572]

Koschella M; Voehringer D; Pircher H. 2004. CD40 ligation in vivo induces bystander proliferation of memory phenotype CD8 T cells. J Immunol 172(8):4804-11. [PubMed: 15067057]  [MGI Ref ID J:89113]

Koustova E; Sei Y; McCarty T; Espey MG; Ming R; Morse HC 3rd; Basile AS. 2000. Accelerated development of neurochemical and behavioral deficits in LP-BM5 infected mice with targeted deletions of the IFN-gamma gene. J Neuroimmunol 108(1-2):112-21. [PubMed: 10900344]  [MGI Ref ID J:102969]

Kovacic B; Stoiber D; Moriggl R; Weisz E; Ott RG; Kreibich R; Levy DE; Beug H; Freissmuth M; Sexl V. 2006. STAT1 acts as a tumor promoter for leukemia development. Cancer Cell 10(1):77-87. [PubMed: 16843267]  [MGI Ref ID J:110949]

Krakowski M; Owens T. 1996. Interferon-gamma confers resistance to experimental allergic encephalomyelitis. Eur J Immunol 26(7):1641-6. [PubMed: 8766573]  [MGI Ref ID J:34161]

Kuhl AA; Pawlowski NN; Grollich K; Loddenkemper C; Zeitz M; Hoffmann JC. 2007. Aggravation of intestinal inflammation by depletion/deficiency of gammadelta T cells in different types of IBD animal models. J Leukoc Biol 81(1):168-75. [PubMed: 17041003]  [MGI Ref ID J:117270]

KuoLee R; Zhao X; Austin J; Harris G; Conlan JW; Chen W. 2007. Mouse model of oral infection with virulent type A Francisella tularensis. Infect Immun 75(4):1651-60. [PubMed: 17242058]  [MGI Ref ID J:119508]

Kupz A; Scott TA; Belz GT; Andrews DM; Greyer M; Lew AM; Brooks AG; Smyth MJ; Curtiss R 3rd; Bedoui S; Strugnell RA. 2013. Contribution of Thy1+ NK cells to protective IFN-gamma production during Salmonella Typhimurium infections. Proc Natl Acad Sci U S A 110(6):2252-7. [PubMed: 23345426]  [MGI Ref ID J:194337]

Kustova Y; Sei Y; Morse HC Jr; Basile AS. 1998. The influence of a targeted deletion of the IFNgamma gene on emotional behaviors. Brain Behav Immun 12(4):308-24. [PubMed: 10080860]  [MGI Ref ID J:54250]

Kweon MN; Fujihashi K; VanCott JL; Higuchi K; Yamamoto M; McGhee JR; Kiyono H. 1998. Lack of orally induced systemic unresponsiveness in IFN-gamma knockout mice. J Immunol 160(4):1687-93. [PubMed: 9469425]  [MGI Ref ID J:45665]

Larena M; Regner M; Lobigs M. 2013. Cytolytic effector pathways and IFN-gamma help protect against Japanese encephalitis. Eur J Immunol 43(7):1789-98. [PubMed: 23568450]  [MGI Ref ID J:201027]

Lavigne LM; Schopf LR; Chung CL; Maylor R; Sypek JP. 1998. The role of recombinant murine IL-12 and IFN-gamma in the pathogenesis of a murine systemic Candida albicans infection. J Immunol 160(1):284-92. [PubMed: 9551982]  [MGI Ref ID J:44920]

Lazar-Molnar E; Gacser A; Freeman GJ; Almo SC; Nathenson SG; Nosanchuk JD. 2008. The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum. Proc Natl Acad Sci U S A 105(7):2658-63. [PubMed: 18268348]  [MGI Ref ID J:132166]

Leadbetter EA; Brigl M; Illarionov P; Cohen N; Luteran MC; Pillai S; Besra GS; Brenner MB. 2008. NK T cells provide lipid antigen-specific cognate help for B cells. Proc Natl Acad Sci U S A 105(24):8339-44. [PubMed: 18550809]  [MGI Ref ID J:137193]

Lean IS; Lacroix-Lamande S; Laurent F; McDonald V. 2006. Role of tumor necrosis factor alpha in development of immunity against Cryptosporidium parvum infection Infect Immun 74(7):4379-4382. [PubMed: 16790816]  [MGI Ref ID J:110124]

Lee CC; Kung JT. 2012. Marginal zone B cell is a major source of Il-10 in Listeria monocytogenes susceptibility. J Immunol 189(7):3319-27. [PubMed: 22933629]  [MGI Ref ID J:190348]

Lee CK; Smith E; Gimeno R; Gertner R; Levy DE. 2000. STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-gamma J Immunol 164(3):1286-92. [PubMed: 10640742]  [MGI Ref ID J:59955]

Lee EY; Schultz KL; Griffin DE. 2013. Mice deficient in interferon-gamma or interferon-gamma receptor 1 have distinct inflammatory responses to acute viral encephalomyelitis. PLoS One 8(10):e76412. [PubMed: 24204622]  [MGI Ref ID J:209188]

Lee HH; Meyer EH; Goya S; Pichavant M; Kim HY; Bu X; Umetsu SE; Jones JC; Savage PB; Iwakura Y; Casasnovas JM; Kaplan G; Freeman GJ; DeKruyff RH; Umetsu DT. 2010. Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity. J Immunol 185(9):5225-35. [PubMed: 20889552]  [MGI Ref ID J:165181]

Lee HJ; Oh YK; Rhee M; Lim JY; Hwang JY; Park YS; Kwon Y; Choi KH; Jo I; Park SI; Gao B; Kim WH. 2007. The role of STAT1/IRF-1 on synergistic ROS production and loss of mitochondrial transmembrane potential during hepatic cell death induced by LPS/d-GalN. J Mol Biol 369(4):967-84. [PubMed: 17475277]  [MGI Ref ID J:122801]

Lee J; Lee J; Park MK; Lim MA; Park EM; Kim EK; Yang EJ; Lee SY; Jhun JY; Park SH; Kim HY; Cho ML. 2013. Interferon gamma suppresses collagen-induced arthritis by regulation of Th17 through the induction of indoleamine-2,3-deoxygenase. PLoS One 8(4):e60900. [PubMed: 23613752]  [MGI Ref ID J:200571]

Lee J; Reinke EK; Zozulya AL; Sandor M; Fabry Z. 2008. Mycobacterium bovis bacille Calmette-Guerin infection in the CNS suppresses experimental autoimmune encephalomyelitis and Th17 responses in an IFN-gamma-independent manner. J Immunol 181(9):6201-12. [PubMed: 18941210]  [MGI Ref ID J:140733]

Lee PY; Li Y; Kumagai Y; Xu Y; Weinstein JS; Kellner ES; Nacionales DC; Butfiloski EJ; van Rooijen N; Akira S; Sobel ES; Satoh M; Reeves WH. 2009. Type I interferon modulates monocyte recruitment and maturation in chronic inflammation. Am J Pathol 175(5):2023-33. [PubMed: 19808647]  [MGI Ref ID J:154704]

Lee SH; Prince JE; Rais M; Kheradmand F; Shardonofsky F; Lu H; Beaudet AL; Smith CW; Soong L; Corry DB. 2003. Differential requirement for CD18 in T-helper effector homing. Nat Med 9(10):1281-6. [PubMed: 14502280]  [MGI Ref ID J:99598]

Lees JR; Golumbek PT; Sim J; Dorsey D; Russell JH. 2008. Regional CNS responses to IFN-gamma determine lesion localization patterns during EAE pathogenesis. J Exp Med 205(11):2633-42. [PubMed: 18852291]  [MGI Ref ID J:141105]

Lengeling A; Pfeffer K; Balling R. 2001. The battle of two genomes: genetics of bacterial host/pathogen interactions in mice. Mamm Genome 12(4):261-71. [PubMed: 11309656]  [MGI Ref ID J:68401]

Lengi AJ; Phillips RA; Karpuzoglu E; Ahmed SA. 2007. Estrogen selectively regulates chemokines in murine splenocytes. J Leukoc Biol 81(4):1065-74. [PubMed: 17185357]  [MGI Ref ID J:121456]

Lepage AC; Buzoni-Gatel D; Bout DT; Kasper LH. 1998. Gut-derived intraepithelial lymphocytes induce long term immunity against Toxoplasma gondii. J Immunol 161(9):4902-8. [PubMed: 9794424]  [MGI Ref ID J:50441]

Leveson-Gower DB; Olson JA; Sega EI; Luong RH; Baker J; Zeiser R; Negrin RS. 2011. Low doses of natural killer T cells provide protection from acute graft-versus-host disease via an IL-4-dependent mechanism. Blood 117(11):3220-9. [PubMed: 21258007]  [MGI Ref ID J:170509]

Lewkowich IP; Rempel JD; HayGlass KT. 2005. Prevention of allergen-specific, Th2-biased immune responses in vivo: role of increased IL-12 and IL-18 responsiveness. J Immunol 175(8):4956-62. [PubMed: 16210597]  [MGI Ref ID J:119100]

Li CK; Pender SL; Pickard KM; Chance V; Holloway JA; Huett A; Goncalves NS; Mudgett JS; Dougan G; Frankel G; MacDonald TT. 2004. Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice. J Immunol 173(8):5171-9. [PubMed: 15470062]  [MGI Ref ID J:93706]

Li CR; Mueller EE; Bradley LM. 2014. Islet antigen-specific Th17 cells can induce TNF-alpha-dependent autoimmune diabetes. J Immunol 192(4):1425-32. [PubMed: 24446517]  [MGI Ref ID J:209355]

Li L; Walker TL; Zhang Y; Mackay EW; Bartlett PF. 2010. Endogenous interferon gamma directly regulates neural precursors in the non-inflammatory brain. J Neurosci 30(27):9038-50. [PubMed: 20610738]  [MGI Ref ID J:161777]

Li S; Choi HJ; Felio K; Wang CR. 2011. Autoreactive CD1b-restricted T cells: a new innate-like T-cell population that contributes to immunity against infection. Blood 118(14):3870-8. [PubMed: 21860021]  [MGI Ref ID J:178396]

Li S; Yan Y; Lin Y; Bullens DM; Rutgeerts O; Goebels J; Segers C; Boon L; Kasran A; De Vos R; Dewolf-Peeters C; Waer M; Billiau AD. 2007. Rapidly induced, T-cell independent xenoantibody production is mediated by marginal zone B cells and requires help from NK cells. Blood 110(12):3926-35. [PubMed: 17630353]  [MGI Ref ID J:149130]

Li W; Murthy AK; Guentzel MN; Seshu J; Forsthuber TG; Zhong G; Arulanandam BP. 2008. Antigen-Specific CD4+ T Cells Produce Sufficient IFN-{gamma} to Mediate Robust Protective Immunity against Genital Chlamydia muridarum Infection. J Immunol 180(5):3375-82. [PubMed: 18292563]  [MGI Ref ID J:131578]

Li X; Lees JR. 2013. Pre-existing central nervous system lesions negate cytokine requirements for regional experimental autoimmune encephalomyelitis development. Immunology 138(3):208-15. [PubMed: 23121407]  [MGI Ref ID J:198090]

Li X; McKinstry KK; Swain SL; Dalton DK. 2007. IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals. J Immunol 179(2):939-49. [PubMed: 17617585]  [MGI Ref ID J:149401]

Li Z; Pradera F; Kammertoens T; Li B; Liu S; Qin Z. 2007. Cross-talk between T cells and innate immune cells is crucial for IFN-gamma-dependent tumor rejection. J Immunol 179(3):1568-76. [PubMed: 17641023]  [MGI Ref ID J:149949]

Liao W; Lin JX; Wang L; Li P; Leonard WJ. 2011. Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages. Nat Immunol 12(6):551-9. [PubMed: 21516110]  [MGI Ref ID J:172804]

Lieberman LA; Cardillo F; Owyang AM; Rennick DM; Cua DJ; Kastelein RA; Hunter CA. 2004. IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12. J Immunol 173(3):1887-93. [PubMed: 15265921]  [MGI Ref ID J:92028]

Lin AE; Ebert G; Ow Y; Preston SP; Toe JG; Cooney JP; Scott HW; Sasaki M; Saibil SD; Dissanayake D; Kim RH; Wakeham A; You-Ten A; Shahinian A; Duncan G; Silvester J; Ohashi PS; Mak TW; Pellegrini M. 2013. ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system. Nat Immunol 14(1):27-33. [PubMed: 23179078]  [MGI Ref ID J:191066]

Lin X; Pease LR; Murray PD; Rodriguez M. 1998. Theiler's virus infection of genetically susceptible mice induces central nervous system-infiltrating CTLs with no apparent viral or major myelin antigenic specificity. J Immunol 160(11):5661-8. [PubMed: 9605173]  [MGI Ref ID J:47789]

Lin Y; Ritchea S; Logar A; Slight S; Messmer M; Rangel-Moreno J; Guglani L; Alcorn JF; Strawbridge H; Park SM; Onishi R; Nyugen N; Walter MJ; Pociask D; Randall TD; Gaffen SL; Iwakura Y; Kolls JK; Khader SA. 2009. Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis. Immunity 31(5):799-810. [PubMed: 19853481]  [MGI Ref ID J:155349]

Lindeman GJ; Wittlin S; Lada H; Naylor MJ; Santamaria M; Zhang JG; Starr R; Hilton DJ; Alexander WS; Ormandy CJ; Visvader J. 2001. SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice. Genes Dev 15(13):1631-6. [PubMed: 11445538]  [MGI Ref ID J:70408]

Listopad JJ; Kammertoens T; Anders K; Silkenstedt B; Willimsky G; Schmidt K; Kuehl AA; Loddenkemper C; Blankenstein T. 2013. Fas expression by tumor stroma is required for cancer eradication. Proc Natl Acad Sci U S A 110(6):2276-81. [PubMed: 23341634]  [MGI Ref ID J:193821]

Litteljohn D; Mangano E; Shukla N; Hayley S. 2009. Interferon-gamma deficiency modifies the motor and co-morbid behavioral pathology and neurochemical changes provoked by the pesticide paraquat. Neuroscience 164(4):1894-906. [PubMed: 19782123]  [MGI Ref ID J:156640]

Liu C; Lou Y; Lizee G; Qin H; Liu S; Rabinovich B; Kim GJ; Wang YH; Ye Y; Sikora AG; Overwijk WW; Liu YJ; Wang G; Hwu P. 2008. Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice. J Clin Invest 118(3):1165-75. [PubMed: 18259609]  [MGI Ref ID J:135308]

Liu G; Yang K; Burns S; Shrestha S; Chi H. 2010. The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells. Nat Immunol 11(11):1047-56. [PubMed: 20852647]  [MGI Ref ID J:166555]

Liu J; Xiang Z; Ma X. 2004. Role of IFN regulatory factor-1 and IL-12 in immunological resistance to pathogenesis of N-methyl-N-nitrosourea-induced T lymphoma. J Immunol 173(2):1184-93. [PubMed: 15240709]  [MGI Ref ID J:91927]

Liu X; Leung S; Wang C; Tan Z; Wang J; Guo TB; Fang L; Zhao Y; Wan B; Qin X; Lu L; Li R; Pan H; Song M; Liu A; Hong J; Lu H; Zhang JZ. 2010. Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nat Med 16(2):191-7. [PubMed: 20062065]  [MGI Ref ID J:157081]

Liu Y; Wang L; Kikuiri T; Akiyama K; Chen C; Xu X; Yang R; Chen W; Wang S; Shi S. 2011. Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-gamma and TNF-alpha. Nat Med 17(12):1594-601. [PubMed: 22101767]  [MGI Ref ID J:180364]

Liu Z; Demitrack ES; Keeley TM; Eaton KA; El-Zaatari M; Merchant JL; Samuelson LC. 2012. IFNgamma contributes to the development of gastric epithelial cell metaplasia in Huntingtin interacting protein 1 related (Hip1r)-deficient mice. Lab Invest 92(7):1045-57. [PubMed: 22525425]  [MGI Ref ID J:185424]

Liu Z; Falo LD Jr; You Z. 2011. Knockdown of HMGB1 in tumor cells attenuates their ability to induce regulatory T cells and uncovers naturally acquired CD8 T cell-dependent antitumor immunity. J Immunol 187(1):118-25. [PubMed: 21642542]  [MGI Ref ID J:176186]

Liu Z; Noh HS; Chen J; Kim JH; Falo LD Jr; You Z. 2008. Potent tumor-specific protection ignited by adoptively transferred CD4+ T cells. J Immunol 181(6):4363-70. [PubMed: 18768895]  [MGI Ref ID J:139077]

Liva SM; Voskuhl RR. 2001. Testosterone acts directly on CD4+ T lymphocytes to increase IL-10 production. J Immunol 167(4):2060-7. [PubMed: 11489988]  [MGI Ref ID J:120413]

Lohr J; Knoechel B; Wang JJ; Villarino AV; Abbas AK. 2006. Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease. J Exp Med 203(13):2785-91. [PubMed: 17130300]  [MGI Ref ID J:124600]

Lord GM; Rao RM; Choe H; Sullivan BM; Lichtman AH; Luscinskas FW; Glimcher LH. 2005. T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood 106(10):3432-9. [PubMed: 16014561]  [MGI Ref ID J:123942]

Lu Y; Giver CR; Sharma A; Li JM; Darlak KA; Owens LM; Roback JD; Galipeau J; Waller EK. 2012. IFN-gamma and indoleamine 2,3-dioxygenase signaling between donor dendritic cells and T cells regulates graft versus host and graft versus leukemia activity. Blood 119(4):1075-85. [PubMed: 22130799]  [MGI Ref ID J:181750]

Lu Y; Hong S; Li H; Park J; Hong B; Wang L; Zheng Y; Liu Z; Xu J; He J; Yang J; Qian J; Yi Q. 2012. Th9 cells promote antitumor immune responses in vivo. J Clin Invest 122(11):4160-71. [PubMed: 23064366]  [MGI Ref ID J:193545]

Lu YJ; Gross J; Bogaert D; Finn A; Bagrade L; Zhang Q; Kolls JK; Srivastava A; Lundgren A; Forte S; Thompson CM; Harney KF; Anderson PW; Lipsitch M; Malley R. 2008. Interleukin-17A mediates acquired immunity to pneumococcal colonization. PLoS Pathog 4(9):e1000159. [PubMed: 18802458]  [MGI Ref ID J:162986]

Luger D; Silver PB; Tang J; Cua D; Chen Z; Iwakura Y; Bowman EP; Sgambellone NM; Chan CC; Caspi RR. 2008. Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med 205(4):799-810. [PubMed: 18391061]  [MGI Ref ID J:133969]

Lukacs-Kornek V; Malhotra D; Fletcher AL; Acton SE; Elpek KG; Tayalia P; Collier AR; Turley SJ. 2011. Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes. Nat Immunol 12(11):1096-104. [PubMed: 21926986]  [MGI Ref ID J:177695]

Luthje K; Kallies A; Shimohakamada Y; TBelz GT; Light A; Tarlinton DM; Nutt SL. 2012. The development and fate of follicular helper T cells defined by an IL-21 reporter mouse. Nat Immunol 13(5):491-8. [PubMed: 22466669]  [MGI Ref ID J:185372]

Ma F; Feng J; Zhang C; Li Y; Qi G; Li H; Wu Y; Fu Y; Zhao Y; Chen H; Du J; Tang H. 2014. The requirement of CD8+ T cells to initiate and augment acute cardiac inflammatory response to high blood pressure. J Immunol 192(7):3365-73. [PubMed: 24600037]  [MGI Ref ID J:210252]

MacNamara KC; Jones M; Martin O; Winslow GM. 2011. Transient activation of hematopoietic stem and progenitor cells by IFNgamma during acute bacterial infection. PLoS One 6(12):e28669. [PubMed: 22194881]  [MGI Ref ID J:182248]

Mackler AM; Barber EM; Takikawa O; Pollard JW. 2003. Indoleamine 2,3-dioxygenase is regulated by IFN-gamma in the mouse placenta during Listeria monocytogenes infection. J Immunol 170(2):823-30. [PubMed: 12517946]  [MGI Ref ID J:127135]

Maeda Y; Reddy P; Lowler KP; Liu C; Bishop DK; Ferrara JL. 2005. Critical role of host gammadelta T cells in experimental acute graft-versus-host disease. Blood 106(2):749-55. [PubMed: 15797996]  [MGI Ref ID J:107458]

Majewska-Szczepanik M; Paust S; von Andrian UH; Askenase PW; Szczepanik M. 2013. Natural killer cell-mediated contact sensitivity develops rapidly and depends on interferon-alpha, interferon-gamma and interleukin-12. Immunology 140(1):98-110. [PubMed: 23659714]  [MGI Ref ID J:202643]

Malone KE; Stohlman SA; Ramakrishna C; Macklin W; Bergmann CC. 2008. Induction of class I antigen processing components in oligodendroglia and microglia during viral encephalomyelitis. Glia 56(4):426-35. [PubMed: 18205173]  [MGI Ref ID J:156284]

Mangano EN; Litteljohn D; So R; Nelson E; Peters S; Bethune C; Bobyn J; Hayley S. 2012. Interferon-gamma plays a role in paraquat-induced neurodegeneration involving oxidative and proinflammatory pathways. Neurobiol Aging 33(7):1411-26. [PubMed: 21482445]  [MGI Ref ID J:188214]

Mann-Chandler MN; Kashyap M; Wright HV; Norozian F; Barnstein BO; Gingras S; Parganas E; Ryan JJ. 2005. IFN-gamma induces apoptosis in developing mast cells. J Immunol 175(5):3000-5. [PubMed: 16116187]  [MGI Ref ID J:113205]

Mansur DS; Kroon EG; Nogueira ML; Arantes RM; Rodrigues SC; Akira S; Gazzinelli RT; Campos MA. 2005. Lethal encephalitis in myeloid differentiation factor 88-deficient mice infected with herpes simplex virus 1. Am J Pathol 166(5):1419-26. [PubMed: 15855642]  [MGI Ref ID J:98429]

Marine JC; Topham DJ; McKay C; Wang D; Parganas E; Stravopodis D; Yoshimura A; Ihle JN. 1999. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 98(5):609-16. [PubMed: 10490100]  [MGI Ref ID J:57475]

Marrero J; Rhee KY; Schnappinger D; Pethe K; Ehrt S. 2010. Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection. Proc Natl Acad Sci U S A 107(21):9819-24. [PubMed: 20439709]  [MGI Ref ID J:160289]

Marshall HD; Prince AL; Berg LJ; Welsh RM. 2010. IFN-alphabeta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions. J Immunol 185(3):1419-28. [PubMed: 20592282]  [MGI Ref ID J:162457]

Martin DL; King CL; Pearlman E; Strine E; Heinzel FP. 2000. IFN-gamma is necessary but not sufficient for anti-CD40 antibody-mediated inhibition of the Th2 response to Schistosoma mansoni eggs. J Immunol 164(2):779-85. [PubMed: 10623823]  [MGI Ref ID J:59303]

Martin ME; Caspersen K; Dumler JS. 2001. Immunopathology and ehrlichial propagation are regulated by interferon-gamma and interleukin-10 in a murine model of human granulocytic ehrlichiosis. Am J Pathol 158(5):1881-8. [PubMed: 11337387]  [MGI Ref ID J:69104]

Martin-Fontecha A; Thomsen LL; Brett S; Gerard C; Lipp M; Lanzavecchia A; Sallusto F. 2004. Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming. Nat Immunol 5(12):1260-5. [PubMed: 15531883]  [MGI Ref ID J:94038]

Martins GA; Campanelli AP; Silva RB; Tadokoro CE; Russo M; Cunha FQ; Rizzo LV; Silva JS. 2004. CD28 is required for T cell activation and IFN-gamma production by CD4+ and CD8+ T cells in response to Trypanosoma cruzi infection. Microbes Infect 6(13):1133-44. [PubMed: 15488732]  [MGI Ref ID J:105590]

Maruyama K; Nakazawa T; Cursiefen C; Maruyama Y; Van Rooijen N; D'Amore PA; Kinoshita S. 2012. The maintenance of lymphatic vessels in the cornea is dependent on the presence of macrophages. Invest Ophthalmol Vis Sci 53(6):3145-53. [PubMed: 22511631]  [MGI Ref ID J:196828]

Masocha W; Robertson B; Rottenberg ME; Mhlanga J; Sorokin L; Kristensson K. 2004. Cerebral vessel laminins and IFN-gamma define Trypanosoma brucei brucei penetration of the blood-brain barrier. J Clin Invest 114(5):689-94. [PubMed: 15343387]  [MGI Ref ID J:92595]

Masse GX; Corcuff E; Strick-Marchand H; Guy-Grand D; Tafuri-Bladt A; Albert ML; Lantz O; Di Santo JP. 2007. Gamma c cytokines condition the progressive differentiation of CD4+ T cells. Proc Natl Acad Sci U S A 104(39):15442-7. [PubMed: 17855567]  [MGI Ref ID J:125207]

Masters SL; Gerlic M; Metcalf D; Preston S; Pellegrini M; O'Donnell JA; McArthur K; Baldwin TM; Chevrier S; Nowell CJ; Cengia LH; Henley KJ; Collinge JE; Kastner DL; Feigenbaum L; Hilton DJ; Alexander WS; Kile BT; Croker BA. 2012. NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells. Immunity 37(6):1009-23. [PubMed: 23219391]  [MGI Ref ID J:191055]

Matsuda H; Takeda K; Koya T; Okamoto M; Shiraishi Y; Miyahara N; Dakhama A; Matsuda JL; Gapin L; Gelfand EW. 2010. Plasticity of invariant NKT cell regulation of allergic airway disease is dependent on IFN-gamma production. J Immunol 185(1):253-62. [PubMed: 20525882]  [MGI Ref ID J:161618]

Mattarollo SR; Rahimpour A; Choyce A; Godfrey DI; Leggatt GR; Frazer IH. 2010. Invariant NKT cells in hyperplastic skin induce a local immune suppressive environment by IFN-gamma production. J Immunol 184(3):1242-50. [PubMed: 20028654]  [MGI Ref ID J:159537]

Mattarollo SR; Yong M; Tan L; Frazer IH; Leggatt GR. 2010. Secretion of IFN-gamma but not IL-17 by CD1d-restricted NKT cells enhances rejection of skin grafts expressing epithelial cell-derived antigen. J Immunol 184(10):5663-9. [PubMed: 20410490]  [MGI Ref ID J:160981]

Matter M; Odermatt B; Yagita H; Nuoffer JM; Ochsenbein AF. 2006. Elimination of chronic viral infection by blocking CD27 signaling. J Exp Med 203(9):2145-55. [PubMed: 16923852]  [MGI Ref ID J:124567]

Maxwell JR; Yadav R; Rossi RJ; Ruby CE; Weinberg AD; Aguila HL; Vella AT. 2006. IL-18 bridges innate and adaptive immunity through IFN-gamma and the CD134 pathway. J Immunol 177(1):234-45. [PubMed: 16785519]  [MGI Ref ID J:134442]

Mayer KD; Mohrs K; Reiley W; Wittmer S; Kohlmeier JE; Pearl JE; Cooper AM; Johnson LL; Woodland DL; Mohrs M. 2008. Cutting edge: T-bet and IL-27R are critical for in vivo IFN-gamma production by CD8 T cells during infection. J Immunol 180(2):693-7. [PubMed: 18178806]  [MGI Ref ID J:130953]

McClary H; Koch R; Chisari FV; Guidotti LG. 2000. Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines. J Virol 74(5):2255-64. [PubMed: 10666256]  [MGI Ref ID J:126989]

McLoughlin RM; Lee JC; Kasper DL; Tzianabos AO. 2008. IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infection. J Immunol 181(2):1323-32. [PubMed: 18606687]  [MGI Ref ID J:137477]

McLoughlin RM; Witowski J; Robson RL; Wilkinson TS; Hurst SM; Williams AS; Williams JD; Rose-John S; Jones SA; Topley N. 2003. Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J Clin Invest 112(4):598-607. [PubMed: 12925700]  [MGI Ref ID J:85159]

Mead JR; You X. 1998. Susceptibility differences to Cryptosporidium parvum infection in two strains of gamma interferon knockout mice. J Parasitol 84(5):1045-8. [PubMed: 9794653]  [MGI Ref ID J:50832]

Medoff BD; Sauty A; Tager AM; Maclean JA; Smith RN; Mathew A; Dufour JH; Luster AD. 2002. IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. J Immunol 168(10):5278-86. [PubMed: 11994485]  [MGI Ref ID J:125569]

Meissner NN; Lund FE; Han S; Harmsen A. 2005. CD8 T cell-mediated lung damage in response to the extracellular pathogen pneumocystis is dependent on MHC class I expression by radiation-resistant lung cells. J Immunol 175(12):8271-9. [PubMed: 16339567]  [MGI Ref ID J:122256]

Mencacci A; Montagnoli C; Bacci A; Cenci E; Pitzurra L; Spreca A; Kopf M; Sharpe AH; Romani L. 2002. CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis. J Immunol 169(6):3180-90. [PubMed: 12218136]  [MGI Ref ID J:120204]

Messingham KA; Badovinac VP; Jabbari A; Harty JT. 2007. A role for IFN-gamma from antigen-specific CD8+ T cells in protective immunity to Listeria monocytogenes. J Immunol 179(4):2457-66. [PubMed: 17675507]  [MGI Ref ID J:151292]

Metcalf D; Alexander WS; Ryan PJ; Mifsud S; Di Rago L. 2001. Production of colony-stimulating factors and il-5 by organs from three types of mice with inflammatory disease due to loss of the suppressor of cytokine signaling-1. J Immunol 167(8):4661-7. [PubMed: 11591796]  [MGI Ref ID J:72058]

Metcalf D; Di Rago L; Mifsud S; Hartley L; Alexander WS. 2000. The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-gamma and lacking the SOCS-1 gene. Proc Natl Acad Sci U S A 97(16):9174-9. [PubMed: 10908669]  [MGI Ref ID J:63845]

Metcalf D; Mifsud S; Di Rago L; Nicola NA; Hilton DJ; Alexander WS. 2002. Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1). Proc Natl Acad Sci U S A 99(2):943-8. [PubMed: 11782537]  [MGI Ref ID J:73987]

Miao EA; Leaf IA; Treuting PM; Mao DP; Dors M; Sarkar A; Warren SE; Wewers MD; Aderem A. 2010. Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol 11(12):1136-42. [PubMed: 21057511]  [MGI Ref ID J:167323]

Michailowsky V; Celes MR; Marino AP; Silva AA; Vieira LQ; Rossi MA; Gazzinelli RT; Lannes-Vieira J; Silva JS. 2004. Intercellular adhesion molecule 1 deficiency leads to impaired recruitment of T lymphocytes and enhanced host susceptibility to infection with Trypanosoma cruzi. J Immunol 173(1):463-70. [PubMed: 15210806]  [MGI Ref ID J:90958]

Mikkelsen M; Holst PJ; Bukh J; Thomsen AR; Christensen JP. 2011. Enhanced and Sustained CD8+ T Cell Responses with an Adenoviral Vector-Based Hepatitis C Virus Vaccine Encoding NS3 Linked to the MHC Class II Chaperone Protein Invariant Chain. J Immunol 186(4):2355-64. [PubMed: 21257961]  [MGI Ref ID J:168988]

Miller HE; Robinson RT. 2012. Early Control of Mycobacterium tuberculosis Infection Requires il12rb1 Expression by rag1-Dependent Lineages. Infect Immun 80(11):3828-41. [PubMed: 22907814]  [MGI Ref ID J:187984]

Millward JM; Lobner M; Wheeler RD; Owens T. 2010. Inflammation in the central nervous system and Th17 responses are inhibited by IFN-gamma-Induced IL-18 binding protein. J Immunol 185(4):2458-66. [PubMed: 20644165]  [MGI Ref ID J:162621]

Mishra BB; Rathinam VA; Martens GW; Martinot AJ; Kornfeld H; Fitzgerald KA; Sassetti CM. 2013. Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1beta. Nat Immunol 14(1):52-60. [PubMed: 23160153]  [MGI Ref ID J:191074]

Mitchell AJ; Yau B; McQuillan JA; Ball HJ; Too LK; Abtin A; Hertzog P; Leib SL; Jones CA; Gerega SK; Weninger W; Hunt NH. 2012. Inflammasome-dependent IFN-gamma drives pathogenesis in Streptococcus pneumoniae meningitis. J Immunol 189(10):4970-80. [PubMed: 23071286]  [MGI Ref ID J:190696]

Mittal D; Kassianos AJ; Tran LS; Bergot AS; Gosmann C; Hofmann J; Blumenthal A; Leggatt GR; Frazer IH. 2013. Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein e7. J Invest Dermatol 133(12):2686-94. [PubMed: 23652797]  [MGI Ref ID J:202874]

Mizoguchi A; Mizoguchi E; Bhan AK. 1999. The critical role of interleukin 4 but not interferon gamma in the pathogenesis of colitis in T-cell receptor alpha mutant mice. Gastroenterology 116(2):320-6. [PubMed: 9922312]  [MGI Ref ID J:92347]

Mizoguchi A; Ogawa A; Takedatsu H; Sugimoto K; Shimomura Y; Shirane K; Nagahama K; Nagaishi T; Mizoguchi E; Blumberg RS; Bhan AK. 2007. Dependence of intestinal granuloma formation on unique myeloid DC-like cells. J Clin Invest 117(3):605-15. [PubMed: 17318261]  [MGI Ref ID J:120740]

Molesworth-Kenyon S; Mates A; Yin R; Strieter R; Oakes J; Lausch R. 2005. CXCR3, IP-10, and Mig are required for CD4+ T cell recruitment during the DTH response to HSV-1 yet are independent of the mechanism for viral clearance. Virology 333(1):1-9. [PubMed: 15708587]  [MGI Ref ID J:101825]

Molesworth-Kenyon SJ; Oakes JE; Lausch RN. 2005. A novel role for neutrophils as a source of T cell-recruiting chemokines IP-10 and Mig during the DTH response to HSV-1 antigen. J Leukoc Biol 77(4):552-9. [PubMed: 15629884]  [MGI Ref ID J:97440]

Molesworth-Kenyon SJ; Yin R; Oakes JE; Lausch RN. 2008. IL-17 receptor signaling influences virus-induced corneal inflammation. J Leukoc Biol 83(2):401-8. [PubMed: 17998300]  [MGI Ref ID J:131214]

Montagnoli C; Fallarino F; Gaziano R; Bozza S; Bellocchio S; Zelante T; Kurup WP; Pitzurra L; Puccetti P; Romani L. 2006. Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism. J Immunol 176(3):1712-23. [PubMed: 16424201]  [MGI Ref ID J:126452]

Montandon R; Korniotis S; Layseca-Espinosa E; Gras C; Megret J; Ezine S; Dy M; Zavala F. 2013. Innate pro-B-cell progenitors protect against type 1 diabetes by regulating autoimmune effector T cells. Proc Natl Acad Sci U S A 110(24):E2199-208. [PubMed: 23716674]  [MGI Ref ID J:197396]

Moreira AP; Campanelli AP; Cavassani KA; Souto JT; Ferreira BR; Martinez R; Rossi MA; Silva JS. 2006. Intercellular adhesion molecule-1 is required for the early formation of granulomas and participates in the resistance of mice to the infection with the fungus Paracoccidioides brasiliensis. Am J Pathol 169(4):1270-81. [PubMed: 17003484]  [MGI Ref ID J:113377]

Moreno SE; Alves-Filho JC; Alfaya TM; da Silva JS; Ferreira SH; Liew FY. 2006. IL-12, but not IL-18, is critical to neutrophil activation and resistance to polymicrobial sepsis induced by cecal ligation and puncture. J Immunol 177(5):3218-24. [PubMed: 16920961]  [MGI Ref ID J:139542]

Moretto MM; Weiss LM; Combe CL; Khan IA. 2007. IFN-gamma-producing dendritic cells are important for priming of gut intraepithelial lymphocyte response against intracellular parasitic infection. J Immunol 179(4):2485-92. [PubMed: 17675510]  [MGI Ref ID J:151290]

Mori T; Kabashima K; Yoshiki R; Sugita K; Shiraishi N; Onoue A; Kuroda E; Kobayashi M; Yamashita U; Tokura Y. 2008. Cutaneous hypersensitivities to hapten are controlled by IFN-gamma-upregulated keratinocyte Th1 chemokines and IFN-gamma-downregulated langerhans cell Th2 chemokines. J Invest Dermatol 128(7):1719-27. [PubMed: 18239613]  [MGI Ref ID J:137532]

Mori Y; Kodaka T; Kato T; Kanagawa EM; Kanagawa O. 2009. Critical role of IFN-gamma in CFA-mediated protection of NOD mice from diabetes development. Int Immunol 21(11):1291-9. [PubMed: 19778991]  [MGI Ref ID J:154177]

Morimoto Y; Bian Y; Gao P; Yashiro-Ohtani Y; Zhou XY; Ono S; Nakahara H; Kogo M; Hamaoka T; Fujiwara H. 2005. Induction of surface CCR4 and its functionality in mouse Th2 cells is regulated differently during Th2 development. J Leukoc Biol 78(3):753-61. [PubMed: 16126843]  [MGI Ref ID J:100501]

Morton J; Coles B; Wright K; Gallimore A; Morrow JD; Terry ES; Anning PB; Morgan BP; Dioszeghy V; Kuhn H; Chaitidis P; Hobbs AJ; Jones SA; O'Donnell VB. 2008. Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFNgamma-dependent iNOS expression in the vasculature of healthy mice. Blood 111(10):5187-94. [PubMed: 18281503]  [MGI Ref ID J:135580]

Mota BE; Gallardo-Romero N; Trindade G; Keckler MS; Karem K; Carroll D; Campos MA; Vieira LQ; da Fonseca FG; Ferreira PC; Bonjardim CA; Damon IK; Kroon EG. 2011. Adverse Events Post Smallpox-Vaccination: Insights from Tail Scarification Infection in Mice with Vaccinia virus. PLoS One 6(4):e18924. [PubMed: 21526210]  [MGI Ref ID J:172270]

Mott KR; Underhill D; Wechsler SL; Ghiasi H. 2008. Lymphoid-related CD11c+ CD8alpha+ dendritic cells are involved in enhancing herpes simplex virus type 1 latency. J Virol 82(20):9870-9. [PubMed: 18667491]  [MGI Ref ID J:153404]

Mount MP; Lira A; Grimes D; Smith PD; Faucher S; Slack R; Anisman H; Hayley S; Park DS. 2007. Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons. J Neurosci 27(12):3328-37. [PubMed: 17376993]  [MGI Ref ID J:119447]

Mullarky IK; Szaba FM; Berggren KN; Kummer LW; Wilhelm LB; Parent MA; Johnson LL; Smiley ST. 2006. Tumor necrosis factor alpha and gamma interferon, but not hemorrhage or pathogen burden, dictate levels of protective fibrin deposition during infection. Infect Immun 74(2):1181-8. [PubMed: 16428767]  [MGI Ref ID J:104988]

Mullarky IK; Szaba FM; Kummer LW; Wilhelm LB; Parent MA; Johnson LL; Smiley ST. 2007. Gamma interferon suppresses erythropoiesis via interleukin-15. Infect Immun 75(5):2630-3. [PubMed: 17307940]  [MGI Ref ID J:121876]

Muller AJ; Filipe-Santos O; Eberl G; Aebischer T; Spath GF; Bousso P. 2012. CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation. Immunity 37(1):147-57. [PubMed: 22727490]  [MGI Ref ID J:187413]

Muralimohan G; Vella AT. 2006. A role for IFNgamma in differential superantigen stimulation of conventional versus plasmacytoid DCs. Cell Immunol 242(1):9-22. [PubMed: 17045255]  [MGI Ref ID J:116765]

Muranski P; Boni A; Antony PA; Cassard L; Irvine KR; Kaiser A; Paulos CM; Palmer DC; Touloukian CE; Ptak K; Gattinoni L; Wrzesinski C; Hinrichs CS; Kerstann KW; Feigenbaum L; Chan CC; Restifo NP. 2008. Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood 112(2):362-73. [PubMed: 18354038]  [MGI Ref ID J:138466]

Murray HW; Montelibano C; Peterson R; Sypek JP. 2000. Interleukin-12 regulates the response to chemotherapy in experimental visceral leishmaniasis J Infect Dis 182(5):1497-502. [PubMed: 11023473]  [MGI Ref ID J:65560]

Murray PJ; Young RA; Daley GQ. 1998. Hematopoietic remodeling in interferon-gamma-deficient mice infected with mycobacteria. Blood 91(8):2914-24. [PubMed: 9531602]  [MGI Ref ID J:47459]

Murugaiyan G; Beynon V; Pires Da Cunha A; Joller N; Weiner HL. 2012. IFN-gamma limits Th9-mediated autoimmune inflammation through dendritic cell modulation of IL-27. J Immunol 189(11):5277-83. [PubMed: 23125412]  [MGI Ref ID J:190977]

Murugaiyan G; Mittal A; Weiner HL. 2010. Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. Proc Natl Acad Sci U S A 107(25):11495-500. [PubMed: 20534530]  [MGI Ref ID J:161596]

Myers L; Croft M; Kwon BS; Mittler RS; Vella AT. 2005. Peptide-specific CD8 T regulatory cells use IFN-gamma to elaborate TGF-beta-based suppression. J Immunol 174(12):7625-32. [PubMed: 15944263]  [MGI Ref ID J:100786]

Nagano H; Mitchell RN; Taylor MK; Hasegawa S; Tilney NL; Libby P. 1997. Interferon-gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts. J Clin Invest 100(3):550-7. [PubMed: 9239401]  [MGI Ref ID J:42090]

Nagayama Y; Saitoh O; McLachlan SM; Rapoport B; Kano H; Kumazawa Y. 2004. TSH receptor-adenovirus-induced Graves' hyperthyroidism is attenuated in both interferon-gamma and interleukin-4 knockout mice; implications for the Th1/Th2 paradigm. Clin Exp Immunol 138(3):417-22. [PubMed: 15544617]  [MGI Ref ID J:94577]

Naka T; Tsutsui H; Fujimoto M; Kawazoe Y; Kohzaki H; Morita Y; Nakagawa R; Narazaki M; Adachi K; Yoshimoto T; Nakanishi K; Kishimoto T. 2001. SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo. Immunity 14(5):535-45. [PubMed: 11371356]  [MGI Ref ID J:69472]

Nakae S; Iwakura Y; Suto H; Galli SJ. 2007. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J Leukoc Biol 81(5):1258-68. [PubMed: 17307864]  [MGI Ref ID J:121718]

Nakae S; Suto H; Berry GJ; Galli SJ. 2007. Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice. Blood 109(9):3640-8. [PubMed: 17197430]  [MGI Ref ID J:145332]

Nakanishi Y; Lu B; Gerard C; Iwasaki A. 2009. CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help. Nature 462(7272):510-3. [PubMed: 19898495]  [MGI Ref ID J:155104]

Nakayamada S; Kanno Y; Takahashi H; Jankovic D; Lu KT; Johnson TA; Sun HW; Vahedi G; Hakim O; Handon R; Schwartzberg PL; Hager GL; O'Shea JJ. 2011. Early Th1 Cell Differentiation Is Marked by a Tfh Cell-like Transition. Immunity 35(6):919-31. [PubMed: 22195747]  [MGI Ref ID J:179278]

Nance S; Cross R; Fitzpatrick E. 2004. Chemokine production during hypersensitivity pneumonitis. Eur J Immunol 34(3):677-85. [PubMed: 14991597]  [MGI Ref ID J:88361]

Nansen A; Jensen T; Christensen JP; Andreasen SO; Ropke C; Marker O; Thomsen AR. 1999. Compromised virus control and augmented perforin-mediated immunopathology in IFN-gamma-deficient mice infected with lymphocytic choriomeningitis virus. J Immunol 163(11):6114-22. [PubMed: 10570301]  [MGI Ref ID J:58651]

Nausch N; Galani IE; Schlecker E; Cerwenka A. 2008. Mononuclear myeloid-derived 'suppressor' cells express RAE-1 and activate natural killer cells. Blood 112(10):4080-9. [PubMed: 18753637]  [MGI Ref ID J:142461]

Nava P; Koch S; Laukoetter MG; Lee WY; Kolegraff K; Capaldo CT; Beeman N; Addis C; Gerner-Smidt K; Neumaier I; Skerra A; Li L; Parkos CA; Nusrat A. 2010. Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways. Immunity 32(3):392-402. [PubMed: 20303298]  [MGI Ref ID J:158902]

Nechushtan H; Pham D; Zhang Y; Morgensztern D; Yi KH; Shin SU; Federoff HJ; Bowers WJ; Tolba KA; Rosenblatt JD. 2008. Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction. Cancer Immunol Immunother 57(5):663-75. [PubMed: 17952436]  [MGI Ref ID J:131193]

Nelson MH; Bird MD; Chu CF; Johnson AJ; Friedrich BM; Allman WR; Milligan GN. 2011. Rapid clearance of herpes simplex virus type 2 by CD8+ T cells requires high level expression of effector T cell functions. J Reprod Immunol 89(1):10-7. [PubMed: 21444117]  [MGI Ref ID J:175956]

Nemeth K; Leelahavanichkul A; Yuen PS; Mayer B; Parmelee A; Doi K; Robey PG; Leelahavanichkul K; Koller BH; Brown JM; Hu X; Jelinek I; Star RA; Mezey E. 2009. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 15(1):42-9. [PubMed: 19098906]  [MGI Ref ID J:146566]

Nesbeth Y; Scarlett U; Cubillos-Ruiz J; Martinez D; Engle X; Turk MJ; Conejo-Garcia JR. 2009. CCL5-mediated endogenous antitumor immunity elicited by adoptively transferred lymphocytes and dendritic cell depletion. Cancer Res 69(15):6331-8. [PubMed: 19602595]  [MGI Ref ID J:150956]

Netea MG; Fantuzzi G; Kullberg BJ; Stuyt RJ; Pulido EJ; McIntyre RC Jr; Joosten LA; Van der Meer JW; Dinarello CA. 2000. Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia. J Immunol 164(5):2644-9. [PubMed: 10679104]  [MGI Ref ID J:126998]

Nguyen HH; van Ginkel FW; Vu HL; Novak MJ; McGhee JR; Mestecky J. 2000. Gamma interferon is not required for mucosal cytotoxic T-lymphocyte responses or heterosubtypic immunity to influenza A virus infection in mice. J Virol 74(12):5495-501. [PubMed: 10823854]  [MGI Ref ID J:62303]

Nishimoto S; Kotani H; Tsuruta S; Shimizu N; Ito M; Shichita T; Morita R; Takahashi H; Amagai M; Yoshimura A. 2013. Th17 cells carrying TCR recognizing epidermal autoantigen induce psoriasis-like skin inflammation. J Immunol 191(6):3065-72. [PubMed: 23956432]  [MGI Ref ID J:205874]

Nolte MA; Arens R; van Os R; van Oosterwijk M; Hooibrink B; van Lier RA; van Oers MH. 2005. Immune activation modulates hematopoiesis through interactions between CD27 and CD70. Nat Immunol 6(4):412-8. [PubMed: 15723067]  [MGI Ref ID J:97606]

North RJ. 1998. Mice incapable of making IL-4 or IL-10 display normal resistance to infection with Mycobacterium tuberculosis. Clin Exp Immunol 113(1):55-8. [PubMed: 9697983]  [MGI Ref ID J:114201]

Novais FO; Carvalho LP; Graff JW; Beiting DP; Ruthel G; Roos DS; Betts MR; Goldschmidt MH; Wilson ME; de Oliveira CI; Scott P. 2013. Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis. PLoS Pathog 9(7):e1003504. [PubMed: 23874205]  [MGI Ref ID J:213470]

Numasaki M; Tagawa M; Iwata F; Suzuki T; Nakamura A; Okada M; Iwakura Y; Aiba S; Yamaya M. 2007. IL-28 elicits antitumor responses against murine fibrosarcoma. J Immunol 178(8):5086-98. [PubMed: 17404291]  [MGI Ref ID J:145280]

Nurieva RI; Chung Y; Hwang D; Yang XO; Kang HS; Ma L; Wang YH; Watowich SS; Jetten AM; Tian Q; Dong C. 2008. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29(1):138-49. [PubMed: 18599325]  [MGI Ref ID J:137869]

O'Connor RA; Li X; Blumerman S; Anderton SM; Noelle RJ; Dalton DK. 2012. Adjuvant Immunotherapy of Experimental Autoimmune Encephalomyelitis: Immature Myeloid Cells Expressing CXCL10 and CXCL16 Attract CXCR3+CXCR6+ and Myelin-Specific T Cells to the Draining Lymph Nodes Rather Than the Central Nervous System. J Immunol 188(5):2093-101. [PubMed: 22287719]  [MGI Ref ID J:181244]

O'Connor RA; Wittmer S; Dalton DK. 2005. Infection-induced apoptosis deletes bystander CD4(+) T cells: a mechanism for suppression of autoimmunity during BCG infection. J Autoimmun 24(2):93-100. [PubMed: 15829401]  [MGI Ref ID J:97542]

O'Konek JJ; Illarionov P; Khursigara DS; Ambrosino E; Izhak L; Castillo BF 2nd; Raju R; Khalili M; Kim HY; Howell AR; Besra GS; Porcelli SA; Berzofsky JA; Terabe M. 2011. Mouse and human iNKT cell agonist beta-mannosylceramide reveals a distinct mechanism of tumor immunity. J Clin Invest 121(2):683-94. [PubMed: 21245578]  [MGI Ref ID J:171830]

Obar JJ; Jellison ER; Sheridan BS; Blair DA; Pham QM; Zickovich JM; Lefrancois L. 2011. Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation. J Immunol 187(10):4967-78. [PubMed: 21987662]  [MGI Ref ID J:179638]

Obayashi K; Doi T; Koyasu S. 2007. Dendritic cells suppress IgE production in B cells. Int Immunol 19(2):217-26. [PubMed: 17208926]  [MGI Ref ID J:117872]

Ochoa-Reparaz J; Sentissi J; Trunkle T; Riccardi C; Pascual DW. 2007. Attenuated Coxiella burnetii phase II causes a febrile response in gamma interferon knockout and Toll-like receptor 2 knockout mice and protects against reinfection. Infect Immun 75(12):5845-58. [PubMed: 17893129]  [MGI Ref ID J:127651]

Oh SJ; Chung DH. 2011. Invariant NKT cells producing IL-4 or IL-10, but not IFN-gamma, inhibit the Th1 response in experimental autoimmune encephalomyelitis, whereas none of these cells inhibits the Th17 response. J Immunol 186(12):6815-21. [PubMed: 21572032]  [MGI Ref ID J:175480]

Ohteki T; Tada H; Ishida K; Sato T; Maki C; Yamada T; Hamuro J; Koyasu S. 2006. Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo. J Exp Med 203(10):2329-38. [PubMed: 16966429]  [MGI Ref ID J:124624]

Okamoto M; Kato S; Oizumi K; Kinoshita M; Inoue Y; Hoshino K; Akira S; McKenzie AN; Young HA; Hoshino T. 2002. Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia. Blood 99(4):1289-98. [PubMed: 11830478]  [MGI Ref ID J:74714]

Olson JA; Leveson-Gower DB; Gill S; Baker J; Beilhack A; Negrin RS. 2010. NK cells mediate reduction of GVHD by inhibiting activated, alloreactive T cells while retaining GVT effects. Blood 115(21):4293-301. [PubMed: 20233969]  [MGI Ref ID J:160227]

Olson MR; Hartwig SM; Varga SM. 2008. The number of respiratory syncytial virus (RSV)-specific memory CD8 T cells in the lung is critical for their ability to inhibit RSV vaccine-enhanced pulmonary eosinophilia. J Immunol 181(11):7958-68. [PubMed: 19017987]  [MGI Ref ID J:142376]

Ordway D; Henao-Tamayo M; Smith E; Shanley C; Harton M; Troudt J; Bai X; Basaraba RJ; Orme IM; Chan ED. 2008. Animal model of Mycobacterium abscessus lung infection. J Leukoc Biol 83(6):1502-11. [PubMed: 18310351]  [MGI Ref ID J:136571]

Ortaldo JR; Winkler-Pickett R; Wigginton J; Horner M; Bere EW; Mason AT; Bhat N; Cherry J; Sanford M; Hodge DL; Young HA. 2006. Regulation of ITAM-positive receptors: role of IL-12 and IL-18. Blood 107(4):1468-75. [PubMed: 16249390]  [MGI Ref ID J:129310]

Ortega SB; Kashi VP; Tyler AF; Cunnusamy K; Mendoza JP; Karandikar NJ. 2013. The disease-ameliorating function of autoregulatory CD8 T cells is mediated by targeting of encephalitogenic CD4 T cells in experimental autoimmune encephalomyelitis. J Immunol 191(1):117-26. [PubMed: 23733879]  [MGI Ref ID J:205352]

Osawa E; Nakajima A; Fujisawa T; Kawamura YI; Toyama-Sorimachi N; Nakagama H; Dohi T. 2006. Predominant T helper type 2-inflammatory responses promote murine colon cancers. Int J Cancer 118(9):2232-6. [PubMed: 16331625]  [MGI Ref ID J:107259]

Ostrand-Rosenberg S; Sinha P; Clements V; Dissanayake SI; Miller S; Davis C; Danna E. 2004. Signal transducer and activator of transcription 6 (Stat6) and CD1: inhibitors of immunosurveillance against primary tumors and metastatic disease. Cancer Immunol Immunother 53(2):86-91. [PubMed: 14593499]  [MGI Ref ID J:86509]

Ousman SS; Wang J; Campbell IL. 2005. Differential regulation of interferon regulatory factor (IRF)-7 and IRF-9 gene expression in the central nervous system during viral infection. J Virol 79(12):7514-27. [PubMed: 15919906]  [MGI Ref ID J:98854]

Ouyang W; Liao W; Luo CT; Yin N; Huse M; Kim MV; Peng M; Chan P; Ma Q; Mo Y; Meijer D; Zhao K; Rudensky AY; Atwal G; Zhang MQ; Li MO. 2012. Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Nature 491(7425):554-9. [PubMed: 23135404]  [MGI Ref ID J:189962]

Paiva CN; Arras RH; Lessa LP; Gibaldi D; Alves L; Metz CN; Gazzinelli R; Pyrrho AS; Lannes-Vieira J; Bozza MT. 2007. Unraveling the lethal synergism between Trypanosoma cruzi infection and LPS: a role for increased macrophage reactivity. Eur J Immunol 37(5):1355-64. [PubMed: 17390393]  [MGI Ref ID J:123561]

Panchanathan V; Chaudhri G; Karupiah G. 2006. Protective immunity against secondary poxvirus infection is dependent on antibody but not on CD4 or CD8 T-cell function. J Virol 80(13):6333-8. [PubMed: 16775321]  [MGI Ref ID J:153332]

Parent MA; Wilhelm LB; Kummer LW; Szaba FM; Mullarky IK; Smiley ST. 2006. Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary Yersinia pestis infection. Infect Immun 74(6):3381-6. [PubMed: 16714568]  [MGI Ref ID J:109236]

Park H; Li Z; Yang XO; Chang SH; Nurieva R; Wang YH; Wang Y; Hood L; Zhu Z; Tian Q; Dong C. 2005. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6(11):1133-41. [PubMed: 16200068]  [MGI Ref ID J:112600]

Park IK; Shultz LD; Letterio JJ; Gorham JD. 2005. TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1. J Immunol 175(9):5666-74. [PubMed: 16237056]  [MGI Ref ID J:119358]

Park JH; Adoro S; Guinter T; Erman B; Alag AS; Catalfamo M; Kimura MY; Cui Y; Lucas PJ; Gress RE; Kubo M; Hennighausen L; Feigenbaum L; Singer A. 2010. Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells. Nat Immunol 11(3):257-64. [PubMed: 20118929]  [MGI Ref ID J:158504]

Park JS; Jung YO; Oh HJ; Park SJ; Heo YJ; Kang CM; Kwok SK; Ju JH; Park KS; Cho ML; Sung YC; Park SH; Kim HY. 2012. Interleukin-27 suppresses osteoclastogenesis via induction of interferon-gamma. Immunology 137(4):326-35. [PubMed: 22812379]  [MGI Ref ID J:189620]

Park SJ; Hughes MA; Burdick M; Strieter RM; Mehrad B. 2009. Early NK cell-derived IFN-{gamma} is essential to host defense in neutropenic invasive aspergillosis. J Immunol 182(7):4306-12. [PubMed: 19299730]  [MGI Ref ID J:147121]

Park Y; Kim HS; Ahn JY; Yun D; Cho ML; Hong S; Kim HY; Chung DH. 2010. IL-12p35 promotes antibody-induced joint inflammation by activating NKT cells and suppressing TGF-beta. J Immunol 185(3):1476-84. [PubMed: 20581146]  [MGI Ref ID J:162473]

Parra B; Hinton DR; Marten NW; Bergmann CC; Lin MT; Yang CS; Stohlman SA. 1999. IFN-gamma is required for viral clearance from central nervous system oligodendroglia. J Immunol 162(3):1641-7. [PubMed: 9973424]  [MGI Ref ID J:112048]

Paunicka K; Chen PW; Niederkorn JY. 2012. Role of IFN-gamma in the establishment of anterior chamber-associated immune deviation (ACAID)-induced CD8+ T regulatory cells. J Leukoc Biol 91(3):475-83. [PubMed: 22180630]  [MGI Ref ID J:181507]

Paust HJ; Turner JE; Riedel JH; Disteldorf E; Peters A; Schmidt T; Krebs C; Velden J; Mittrucker HW; Steinmetz OM; Stahl RA; Panzer U. 2012. Chemokines play a critical role in the cross-regulation of Th1 and Th17 immune responses in murine crescentic glomerulonephritis. Kidney Int 82(1):72-83. [PubMed: 22495297]  [MGI Ref ID J:198177]

Pearl JE; Saunders B; Ehlers S; Orme IM; Cooper AM. 2001. Inflammation and lymphocyte activation during mycobacterial infection in the interferon-gamma-deficient mouse. Cell Immunol 211(1):43-50. [PubMed: 11585387]  [MGI Ref ID J:71972]

Peng SL; Moslehi J; Craft J. 1997. Roles of interferon-gamma and interleukin-4 in murine lupus. J Clin Invest 99(8):1936-46. [PubMed: 9109438]  [MGI Ref ID J:39600]

Peng W; Liu C; Xu C; Lou Y; Chen J; Yang Y; Yagita H; Overwijk WW; Lizee G; Radvanyi L; Hwu P. 2012. PD-1 blockade enhances T-cell migration to tumors by elevating IFN-gamma inducible chemokines. Cancer Res 72(20):5209-18. [PubMed: 22915761]  [MGI Ref ID J:191805]

Perona-Wright G; Mohrs K; Mohrs M. 2010. Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node. Nat Immunol 11(6):520-6. [PubMed: 20418876]  [MGI Ref ID J:160618]

Perry LL; Feilzer K; Caldwell HD. 1997. Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-gamma-dependent and -independent pathways. J Immunol 158(7):3344-52. [PubMed: 9120292]  [MGI Ref ID J:110834]

Petritus PM; Burns JM Jr. 2008. Suppression of lethal Plasmodium yoelii malaria following protective immunization requires antibody-, IL-4-, and IFN-gamma-dependent responses induced by vaccination and/or challenge infection. J Immunol 180(1):444-53. [PubMed: 18097046]  [MGI Ref ID J:130916]

Petro M; Kish D; Guryanova OA; Ilyinskaya G; Kondratova A; Fairchild RL; Gorbachev AV. 2013. Cutaneous Tumors Cease CXCL9/Mig Production as a Result of IFN-gamma-Mediated Immunoediting. J Immunol 190(2):832-41. [PubMed: 23241877]  [MGI Ref ID J:191044]

Petry F; Jakobi V; Wagner S; Tessema TS; Thiel S; Loos M. 2008. Binding and activation of human and mouse complement by Cryptosporidium parvum (Apicomplexa) and susceptibility of C1q- and MBL-deficient mice to infection. Mol Immunol 45(12):3392-400. [PubMed: 18501966]  [MGI Ref ID J:137680]

Phares TW; Ramakrishna C; Parra GI; Epstein A; Chen L; Atkinson R; Stohlman SA; Bergmann CC. 2009. Target-dependent B7-H1 regulation contributes to clearance of central nervous system infection and dampens morbidity. J Immunol 182(9):5430-8. [PubMed: 19380790]  [MGI Ref ID J:147948]

Pilione MR; Harvill ET. 2006. The Bordetella bronchiseptica type III secretion system inhibits gamma interferon production that is required for efficient antibody-mediated bacterial clearance. Infect Immun 74(2):1043-9. [PubMed: 16428751]  [MGI Ref ID J:105004]

Pilz A; Kratky W; Stockinger S; Simma O; Kalinke U; Lingnau K; von Gabain A; Stoiber D; Sexl V; Kolbe T; Rulicke T; Muller M; Decker T. 2009. Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL. J Immunol 183(4):2286-93. [PubMed: 19620292]  [MGI Ref ID J:151558]

Plitas G; Chaudhry UI; Kingham TP; Raab JR; DeMatteo RP. 2007. NK dendritic cells are innate immune responders to Listeria monocytogenes infection. J Immunol 178(7):4411-6. [PubMed: 17371998]  [MGI Ref ID J:145143]

Polchert D; Sobinsky J; Douglas G; Kidd M; Moadsiri A; Reina E; Genrich K; Mehrotra S; Setty S; Smith B; Bartholomew A. 2008. IFN-gamma activation of mesenchymal stem cells for treatment and prevention of graft versus host disease. Eur J Immunol 38(6):1745-55. [PubMed: 18493986]  [MGI Ref ID J:136408]

Pomeroy C; Delong D; Clabots C; Riciputi P; Filice GA. 1998. Role of interferon-gamma in murine cytomegalovirus infection. J Lab Clin Med 132(2):124-33. [PubMed: 9708573]  [MGI Ref ID J:49105]

Ponomarev ED; Novikova M; Yassai M; Szczepanik M; Gorski J; Dittel BN. 2004. Gamma delta T cell regulation of IFN-gamma production by central nervous system-infiltrating encephalitogenic T cells: correlation with recovery from experimental autoimmune encephalomyelitis. J Immunol 173(3):1587-95. [PubMed: 15265886]  [MGI Ref ID J:92038]

Poovassery J; Moore JM. 2009. Association of malaria-induced murine pregnancy failure with robust peripheral and placental cytokine responses. Infect Immun 77(11):4998-5006. [PubMed: 19687196]  [MGI Ref ID J:154201]

Poovassery JS; Sarr D; Smith G; Nagy T; Moore JM. 2009. Malaria-induced murine pregnancy failure: distinct roles for IFN-gamma and TNF. J Immunol 183(8):5342-9. [PubMed: 19783682]  [MGI Ref ID J:153598]

Portillo JA; Feliciano LM; Okenka G; Heinzel F; Subauste MC; Subauste CS. 2012. CD40 and tumour necrosis factor-alpha co-operate to up-regulate inducuble nitric oxide synthase expression in macrophages. Immunology 135(2):140-50. [PubMed: 22044243]  [MGI Ref ID J:181390]

Poudrier J; Weng X; Kay DG; Pare G; Calvo EL; Hanna Z; Kosco-Vilbois MH; Jolicoeur P. 2001. The AIDS disease of CD4C/HIV transgenic mice shows impaired germinal centers and autoantibodies and develops in the absence of IFN-gamma and IL-6. Immunity 15(2):173-85. [PubMed: 11520454]  [MGI Ref ID J:131516]

Prajeeth CK; Haeberlein S; Sebald H; Schleicher U; Bogdan C. 2011. Leishmania-infected macrophages are targets of NK cell-derived cytokines but not of NK cell cytotoxicity. Infect Immun 79(7):2699-708. [PubMed: 21518784]  [MGI Ref ID J:173486]

Purdy A; Case L; Duvall M; Overstrom-Coleman M; Monnier N; Chervonsky A; Golovkina T. 2003. Unique Resistance of I/LnJ Mice to a Retrovirus Is Due to Sustained Interferon gamma-dependent Production of Virus-neutralizing Antibodies. J Exp Med 197(2):233-43. [PubMed: 12538662]  [MGI Ref ID J:81554]

Purushothaman D; Marcel N; Garg M; Venkataraman R; Sarin A. 2013. Apoptotic Programs Are Determined during Lineage Commitment of CD4+ T Effectors: Selective Regulation of T Effector-Memory Apoptosis by Inducible Nitric Oxide Synthase. J Immunol 190(1):97-105. [PubMed: 23225886]  [MGI Ref ID J:190816]

Putz EM; Gotthardt D; Hoermann G; Csiszar A; Wirth S; Berger A; Straka E; Rigler D; Wallner B; Jamieson AM; Pickl WF; Zebedin-Brandl EM; Muller M; Decker T; Sexl V. 2013. CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance. Cell Rep 4(3):437-44. [PubMed: 23933255]  [MGI Ref ID J:201893]

Qian Q; Cutler JE. 1997. Gamma interferon is not essential in host defense against disseminated candidiasis in mice. Infect Immun 65(5):1748-53. [PubMed: 9125557]  [MGI Ref ID J:39881]

Qiu H; Kuolee R; Harris G; Zhou H; Miller H; Patel GB; Chen W. 2011. Acinetobacter baumannii Infection Inhibits Airway Eosinophilia and Lung Pathology in a Mouse Model of Allergic Asthma. PLoS One 6(7):e22004. [PubMed: 21789200]  [MGI Ref ID J:174930]

Quezada SA; Simpson TR; Peggs KS; Merghoub T; Vider J; Fan X; Blasberg R; Yagita H; Muranski P; Antony PA; Restifo NP; Allison JP. 2010. Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts. J Exp Med 207(3):637-50. [PubMed: 20156971]  [MGI Ref ID J:158560]

Quick ML; Wong L; Mukherjee S; Done JD; Schaeffer AJ; Thumbikat P. 2013. Th1-Th17 cells contribute to the development of uropathogenic Escherichia coli-induced chronic pelvic pain. PLoS One 8(4):e60987. [PubMed: 23577183]  [MGI Ref ID J:199930]

Raisanen-Sokolowski A; Mottram PL; Glysing-Jensen T; Satoskar A; Russell ME. 1997. Heart transplants in interferon-gamma, interleukin 4, and interleukin 10 knockout mice. Recipient environment alters graft rejection. J Clin Invest 100(10):2449-56. [PubMed: 9366559]  [MGI Ref ID J:44346]

Ramanathan S; Dubois S; Gagnon J; Leblanc C; Mariathasan S; Ferbeyre G; Rottapel R; Ohashi PS; Ilangumaran S. 2010. Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens. J Immunol 185(1):357-66. [PubMed: 20519645]  [MGI Ref ID J:161432]

Ramanathan S; Gagnon J; Leblanc C; Rottapel R; Ilangumaran S. 2006. Suppressor of cytokine signaling 1 stringently regulates distinct functions of IL-7 and IL-15 in vivo during T lymphocyte development and homeostasis. J Immunol 176(7):4029-41. [PubMed: 16547238]  [MGI Ref ID J:108365]

Ramassar V; Goes N; Hobart M; Halloran PF. 1996. Evidence for the in vivo role of class II transactivator in basal and IFN-gamma induced class II expression in mouse tissue. Transplantation 62(12):1901-7. [PubMed: 8990384]  [MGI Ref ID J:37404]

Ramirez-Montagut T; Chow A; Hirschhorn-Cymerman D; Terwey TH; Kochman AA; Lu S; Miles RC; Sakaguchi S; Houghton AN; van den Brink MR. 2006. Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity. J Immunol 176(11):6434-42. [PubMed: 16709800]  [MGI Ref ID J:131776]

Reboldi A; Coisne C; Baumjohann D; Benvenuto F; Bottinelli D; Lira S; Uccelli A; Lanzavecchia A; Engelhardt B; Sallusto F. 2009. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol 10(5):514-23. [PubMed: 19305396]  [MGI Ref ID J:148286]

Reddy P; Teshima T; Kukuruga M; Ordemann R; Liu C; Lowler K; Ferrara JL. 2001. Interleukin-18 regulates acute graft-versus-host disease by enhancing Fas-mediated donor T cell apoptosis. J Exp Med 194(10):1433-40. [PubMed: 11714750]  [MGI Ref ID J:114012]

Reeve VE; Bosnic M; Nishimura N. 1999. Interferon-gamma is involved in photoimmunoprotection by UVA (320-400 nm) radiation in mice. J Invest Dermatol 112(6):945-50. [PubMed: 10383743]  [MGI Ref ID J:55740]

Reid-Yu SA; Small CL; Coombes BK. 2013. CD3(-) NK1.1(+) cells aid in the early induction of a Th1 response to an attaching and effacing enteric pathogen. Eur J Immunol 43(10):2638-49. [PubMed: 23775576]  [MGI Ref ID J:201699]

Richter K; Hausmann J; Staeheli P. 2009. Interferon-gamma prevents death of bystander neurons during CD8 T cell responses in the brain. Am J Pathol 174(5):1799-807. [PubMed: 19359516]  [MGI Ref ID J:147967]

Rigato PO; de Alencar BC; de Vasconcelos JR; Dominguez MR; Araujo AF; Machado AV; Gazzinelli RT; Bruna-Romero O; Rodrigues MM. 2011. Heterologous Plasmid DNA Prime-Recombinant Human Adenovirus 5 Boost Vaccination Generates a Stable Pool of Protective Long-Lived CD8+ T Effector Memory Cells Specific for a Human Parasite, Trypanosoma cruzi. Infect Immun 79(5):2120-30. [PubMed: 21357719]  [MGI Ref ID J:171948]

Rijneveld AW; Lauw FN; Schultz MJ; Florquin S; Te Velde AA; Speelman P; Van Deventer SJ; Van Der Poll T. 2002. The role of interferon-gamma in murine pneumococcal pneumonia. J Infect Dis 185(1):91-7. [PubMed: 11756986]  [MGI Ref ID J:73620]

Ring GH; Dai Z; Saleem S; Baddoura FK; Lakkis FG. 1999. Increased susceptibility to immunologically mediated glomerulonephritis in IFN-gamma-deficient mice. J Immunol 163(4):2243-8. [PubMed: 10438967]  [MGI Ref ID J:118730]

Ripley BJ; Fujimoto M; Serada S; Ohkawara T; Nishikawa T; Terabe F; Matsukawa Y; Stephanou A; Knight RA; Isenberg DA; Latchman DS; Kishimoto T; Naka T. 2010. Green tea polyphenol epigallocatechin gallate inhibits cell signaling by inducing SOCS1 gene expression. Int Immunol 22(5):359-66. [PubMed: 20190037]  [MGI Ref ID J:159636]

Rivera A; Hohl TM; Collins N; Leiner I; Gallegos A; Saijo S; Coward JW; Iwakura Y; Pamer EG. 2011. Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation. J Exp Med 208(2):369-81. [PubMed: 21242294]  [MGI Ref ID J:176853]

Rizzo A; Waldner MJ; Stolfi C; Sarra M; Fina D; Becker C; Neurath MF; Macdonald TT; Pallone F; Monteleone G; Fantini MC. 2011. Smad7 Expression in T cells Prevents Colitis-Associated Cancer. Cancer Res 71(24):7423-32. [PubMed: 22028324]  [MGI Ref ID J:178845]

Robinson RT; Wang J; Cripps JG; Milks MW; English KA; Pearson TA; Gorham JD. 2009. End-organ damage in a mouse model of fulminant liver inflammation requires CD4+ T cell production of IFN-gamma but is independent of Fas. J Immunol 182(5):3278-84. [PubMed: 19234226]  [MGI Ref ID J:146230]

Rocha VZ; Folco EJ; Sukhova G; Shimizu K; Gotsman I; Vernon AH; Libby P. 2008. Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ Res 103(5):467-76. [PubMed: 18658050]  [MGI Ref ID J:152646]

Roda JM; Parihar R; Lehman A; Mani A; Tridandapani S; Carson WE 3rd. 2006. Interleukin-21 enhances NK cell activation in response to antibody-coated targets. J Immunol 177(1):120-9. [PubMed: 16785506]  [MGI Ref ID J:134405]

Rodeghero R; Cao Y; Olalekan SA; Iwakua Y; Glant TT; Finnegan A. 2013. Location of CD4+ T cell priming regulates the differentiation of Th1 and Th17 cells and their contribution to arthritis. J Immunol 190(11):5423-35. [PubMed: 23630349]  [MGI Ref ID J:204778]

Rodriguez M; Zoecklein LJ; Howe CL; Pavelko KD; Gamez JD; Nakane S; Papke LM. 2003. Gamma interferon is critical for neuronal viral clearance and protection in a susceptible mouse strain following early intracranial Theiler's murine encephalomyelitis virus infection. J Virol 77(22):12252-65. [PubMed: 14581562]  [MGI Ref ID J:86326]

Rodriguez-Galan MC; Bream JH; Farr A; Young HA. 2005. Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression. J Immunol 174(5):2796-804. [PubMed: 15728489]  [MGI Ref ID J:97710]

Roelofs-Haarhuis K; Wu X; Gleichmann E. 2004. Oral tolerance to nickel requires CD4+ invariant NKT cells for the infectious spread of tolerance and the induction of specific regulatory T cells. J Immunol 173(2):1043-50. [PubMed: 15240692]  [MGI Ref ID J:91933]

Rolan HG; Tsolis RM. 2007. Mice lacking components of adaptive immunity show increased Brucella abortus virB mutant colonization. Infect Immun 75(6):2965-73. [PubMed: 17420243]  [MGI Ref ID J:121919]

Romero CR; Herzig DS; Etogo A; Nunez J; Mahmoudizad R; Fang G; Murphey ED; Toliver-Kinsky T; Sherwood ER. 2010. The role of interferon-gamma in the pathogenesis of acute intra-abdominal sepsis. J Leukoc Biol 88(4):725-35. [PubMed: 20628064]  [MGI Ref ID J:165614]

Rosas LE; Snider HM; Barbi J; Satoskar AA; Lugo-Villarino G; Keiser T; Papenfuss T; Durbin JE; Radzioch D; Glimcher LH; Satoskar AR. 2006. Cutting edge: STAT1 and T-bet play distinct roles in determining outcome of visceral leishmaniasis caused by Leishmania donovani. J Immunol 177(1):22-5. [PubMed: 16785492]  [MGI Ref ID J:134384]

Rosenzweig HL; Kawaguchi T; Martin TM; Planck SR; Davey MP; Rosenbaum JT. 2009. Nucleotide oligomerization domain-2 (NOD2)-induced uveitis: dependence on IFN-gamma. Invest Ophthalmol Vis Sci 50(4):1739-45. [PubMed: 19098321]  [MGI Ref ID J:146921]

Rosypal AC; Lindsay DS; Duncan R Jr; Ahmed SA; Zajac AM; Dubey JP. 2002. Mice lacking the gene for inducible or endothelial nitric oxide are resistant to sporocyst induced Sarcocystis neurona infections. Vet Parasitol 103(4):315-21. [PubMed: 11777610]  [MGI Ref ID J:106322]

Rothfuchs AG; Trumstedt C; Mattei F; Schiavoni G; Hidmark A; Wigzell H; Rottenberg ME. 2006. STAT1 regulates IFN-alpha beta- and IFN-gamma-dependent control of infection with Chlamydia pneumoniae by nonhemopoietic cells. J Immunol 176(11):6982-90. [PubMed: 16709859]  [MGI Ref ID J:131788]

Rothhammer V; Heink S; Petermann F; Srivastava R; Claussen MC; Hemmer B; Korn T. 2011. Th17 lymphocytes traffic to the central nervous system independently of alpha4 integrin expression during EAE. J Exp Med 208(12):2465-76. [PubMed: 22025301]  [MGI Ref ID J:178760]

Rottman M; Soudais C; Vogt G; Renia L; Emile JF; Decaluwe H; Gaillard JL; Casanova JL. 2008. IFN-gamma mediates the rejection of haematopoietic stem cells in IFN-gammaR1-deficient hosts. PLoS Med 5(1):e26. [PubMed: 18232731]  [MGI Ref ID J:134158]

Rudmann DG; Preston AM; Moore MW; Beck JM. 1998. Susceptibility to Pneumocystis carinii in mice is dependent on simultaneous deletion of IFN-gamma and type 1 and 2 TNF receptor genes. J Immunol 161(1):360-6. [PubMed: 9647244]  [MGI Ref ID J:119206]

Rudner LA; Lin JT; Park IK; Cates JM; Dyer DA; Franz DM; French MA; Duncan EM; White HD; Gorham JD. 2003. Necroinflammatory Liver Disease in BALB/c Background, TGF-beta1-Deficient Mice Requires CD4(+) T Cells. J Immunol 170(9):4785-92. [PubMed: 12707360]  [MGI Ref ID J:83022]

Russell MS; Dudani R; Krishnan L; Sad S. 2009. IFN-gamma expressed by T cells regulates the persistence of antigen presentation by limiting the survival of dendritic cells. J Immunol 183(12):7710-8. [PubMed: 19923462]  [MGI Ref ID J:157498]

Rutigliano JA; Graham BS. 2004. Prolonged production of TNF-alpha exacerbates illness during respiratory syncytial virus infection. J Immunol 173(5):3408-17. [PubMed: 15322205]  [MGI Ref ID J:92711]

Rutitzky LI; Lopes da Rosa JR; Stadecker MJ. 2005. Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is dependent on IL-12p40 and correlates with high levels of IL-17. J Immunol 175(6):3920-6. [PubMed: 16148138]  [MGI Ref ID J:116693]

Rutitzky LI; Stadecker MJ. 2011. Exacerbated egg-induced immunopathology in murine Schistosoma mansoni infection is primarily mediated by IL-17 and restrained by IFN-gamma. Eur J Immunol 41(9):2677-87. [PubMed: 21660933]  [MGI Ref ID J:176818]

Sabatino JJ Jr; Shires J; Altman JD; Ford ML; Evavold BD. 2008. Loss of IFN-{gamma} Enables the Expansion of Autoreactive CD4+ T Cells to Induce Experimental Autoimmune Encephalomyelitis by a Nonencephalitogenic Myelin Variant Antigen. J Immunol 180(7):4451-7. [PubMed: 18354166]  [MGI Ref ID J:132970]

Sabino GJ; Hwang SJ; McAllister SC; Mena P; Furie MB. 2011. Interferon-gamma Influences the Composition of Leukocytic Infiltrates in Murine Lyme Carditis. Am J Pathol 179(4):1917-28. [PubMed: 21820995]  [MGI Ref ID J:176303]

Saito TI; Li HW; Sykes M. 2010. Invariant NKT cells are required for antitumor responses induced by host-versus-graft responses. J Immunol 185(4):2099-105. [PubMed: 20631307]  [MGI Ref ID J:162553]

Salagianni M; Wong KL; Thomas MJ; Noble A; Kemeny DM. 2007. An essential role for IL-18 in CD8 T cell-mediated suppression of IgE responses. J Immunol 178(8):4771-8. [PubMed: 17404257]  [MGI Ref ID J:145203]

Salazar-Mather TP; Hamilton TA; Biron CA. 2000. A chemokine-to-cytokine-to-chemokine cascade critical in antiviral defense. J Clin Invest 105(7):985-93. [PubMed: 10749577]  [MGI Ref ID J:120540]

Sangaletti S; Tripodo C; Chiodoni C; Guarnotta C; Cappetti B; Casalini P; Piconese S; Parenza M; Guiducci C; Vitali C; Colombo MP. 2012. Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity. Blood 120(15):3007-18. [PubMed: 22932797]  [MGI Ref ID J:192930]

Santiago HC; Feng CG; Bafica A; Roffe E; Arantes RM; Cheever A; Taylor G; Vieira LQ; Aliberti J; Gazzinelli RT; Sher A. 2005. Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth. J Immunol 175(12):8165-72. [PubMed: 16339555]  [MGI Ref ID J:122278]

Santiago Hda C; Oliveira CF; Santiago L; Ferraz FO; de Souza Dda G; de-Freitas LA; Afonso LC; Teixeira MM; Gazzinelli RT; Vieira LQ. 2004. Involvement of the chemokine RANTES (CCL5) in resistance to experimental infection with Leishmania major. Infect Immun 72(8):4918-23. [PubMed: 15271961]  [MGI Ref ID J:91807]

Sarasin-Filipowicz M; Wang X; Yan M; Duong FH; Poli V; Hilton DJ; Zhang DE; Heim MH. 2009. Alpha interferon induces long-lasting refractoriness of JAK-STAT signaling in the mouse liver through induction of USP18/UBP43. Mol Cell Biol 29(17):4841-51. [PubMed: 19564419]  [MGI Ref ID J:152613]

Sarawar SR; Cardin RD; Brooks JW; Mehrpooya M; Hamilton-Easton AM; Mo XY; Doherty PC. 1997. Gamma interferon is not essential for recovery from acute infection with murine gammaherpesvirus 68. J Virol 71(5):3916-21. [PubMed: 9094668]  [MGI Ref ID J:39478]

Sardinha LR; Elias RM; Mosca T; Bastos KR; Marinho CR; D'Imperio Lima MR; Alvarez JM. 2006. Contribution of NK, NK T, gammadelta T, and alphabeta T cells to the gamma interferon response required for liver protection against Trypanosoma cruzi. Infect Immun 74(4):2031-42. [PubMed: 16552032]  [MGI Ref ID J:107423]

Savinov AY; Wong FS; Chervonsky AV. 2001. IFN-gamma Affects Homing of Diabetogenic T Cells. J Immunol 167(11):6637-43. [PubMed: 11714835]  [MGI Ref ID J:72818]

Scapini P; Hu Y; Chu CL; Migone TS; Defranco AL; Cassatella MA; Lowell CA. 2010. Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med 207(8):1757-73. [PubMed: 20624892]  [MGI Ref ID J:163472]

Scharton-Kersten T; Contursi C; Masumi A; Sher A; Ozato K. 1997. Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. J Exp Med 186(9):1523-34. [PubMed: 9348310]  [MGI Ref ID J:111178]

Scharton-Kersten TM; Wynn TA; Denkers EY; Bala S; Grunvald E; Hieny S; Gazzinelli RT; Sher A. 1996. In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. J Immunol 157(9):4045-54. [PubMed: 8892638]  [MGI Ref ID J:110826]

Scheckelhoff M; Deepe GS Jr. 2005. A deficiency in gamma interferon or interleukin-10 modulates T-Cell-dependent responses to heat shock protein 60 from Histoplasma capsulatum. Infect Immun 73(4):2129-34. [PubMed: 15784555]  [MGI Ref ID J:97204]

Schenkel JM; Fraser KA; Vezys V; Masopust D. 2013. Sensing and alarm function of resident memory CD8(+) T cells. Nat Immunol 14(5):509-13. [PubMed: 23542740]  [MGI Ref ID J:196440]

Schiffmann S; Ferreiros N; Birod K; Eberle M; Schreiber Y; Pfeilschifter W; Ziemann U; Pierre S; Scholich K; Grosch S; Geisslinger G. 2012. Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis. J Immunol 188(11):5723-33. [PubMed: 22544924]  [MGI Ref ID J:188736]

Schindler H; Lutz MB; Rollinghoff M; Bogdan C. 2001. The production of IFN-gamma by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4. J Immunol 166(5):3075-82. [PubMed: 11207258]  [MGI Ref ID J:126694]

Schmidt C; Hocherl K; Bucher M. 2007. Cytokine-mediated regulation of urea transporters during experimental endotoxemia. Am J Physiol Renal Physiol 292(5):F1479-89. [PubMed: 17229673]  [MGI Ref ID J:121446]

Schmitt EG; Haribhai D; Jeschke JC; Co DO; Ziegelbauer J; Yan K; Iwakura Y; Mishra MK; Simpson P; Salzman NH; Williams CB. 2013. Chronic follicular bronchiolitis requires antigen-specific regulatory T cell control to prevent fatal disease progression. J Immunol 191(11):5460-76. [PubMed: 24163409]  [MGI Ref ID J:207015]

Schwarze J; Cieslewicz G; Hamelmann E; Joetham A; Shultz LD; Lamers MC; Gelfand EW. 1999. IL-5 and eosinophils are essential for the development of airway hyperresponsiveness following acute respiratory syncytial virus infection. J Immunol 162(5):2997-3004. [PubMed: 10072551]  [MGI Ref ID J:110844]

Scott MJ; Hoth JJ; Stagner MK; Gardner SA; Peyton JC; Cheadle WG. 2004. CD40-CD154 interactions between macrophages and natural killer cells during sepsis are critical for macrophage activation and are not interferon gamma dependent. Clin Exp Immunol 137(3):469-77. [PubMed: 15320895]  [MGI Ref ID J:92312]

Scurlock AM; Frazer LC; Andrews CW Jr; O'Connell CM; Foote IP; Bailey SL; Chandra-Kuntal K; Kolls JK; Darville T. 2011. Interleukin-17 Contributes to Generation of Th1 Immunity and Neutrophil Recruitment during Chlamydia muridarum Genital Tract Infection but Is Not Required for Macrophage Influx or Normal Resolution of Infection. Infect Immun 79(3):1349-62. [PubMed: 21149587]  [MGI Ref ID J:169254]

Segal BM; Dwyer BK; Shevach EM. 1998. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J Exp Med 187(4):537-46. [PubMed: 9463404]  [MGI Ref ID J:118559]

Segawa S; Goto D; Yoshiga Y; Horikoshi M; Sugihara M; Hayashi T; Chino Y; Matsumoto I; Ito S; Sumida T. 2011. Involvement of NK 1.1-positive gammadeltaT cells in interleukin-18 plus interleukin-2-induced interstitial lung disease. Am J Respir Cell Mol Biol 45(3):659-66. [PubMed: 21257923]  [MGI Ref ID J:190220]

Seif AE; Barrett DM; Milone M; Brown VI; Grupp SA; Reid GS. 2009. Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses. Blood 114(12):2459-66. [PubMed: 19636062]  [MGI Ref ID J:152910]

Sercan O; Stoycheva D; Hammerling GJ; Arnold B; Schuler T. 2010. IFN-gamma receptor signaling regulates memory CD8+ T cell differentiation. J Immunol 184(6):2855-62. [PubMed: 20164422]  [MGI Ref ID J:160112]

Serreze DV; Chapman HD; Post CM; Johnson EA; Suarez-Pinzon WL; Rabinovitch A. 2001. Th1 to Th2 cytokine shifts in nonobese diabetic mice: sometimes an outcome, rather than the cause, of diabetes resistance elicited by immunostimulation. J Immunol 166(2):1352-9. [PubMed: 11145720]  [MGI Ref ID J:109883]

Serreze DV; Wasserfall C; Ottendorfer EW; Stalvey M; Pierce MA; Gauntt C; O'Donnell B; Flanagan JB; Campbell-Thompson M; Ellis TM; Atkinson MA. 2005. Diabetes acceleration or prevention by a coxsackievirus B4 infection: critical requirements for both interleukin-4 and gamma interferon. J Virol 79(2):1045-52. [PubMed: 15613333]  [MGI Ref ID J:95105]

Seymour BW; Gershwin LJ; Coffman RL. 1998. Aerosol-induced immunoglobulin (Ig)-E unresponsiveness to ovalbumin does not require CD8+ or T cell receptor (TCR)-gamma/delta+ T cells or interferon (IFN)-gamma in a murine model of allergen sensitization. J Exp Med 187(5):721-31. [PubMed: 9480982]  [MGI Ref ID J:46078]

Shafiani S; Dinh C; Ertelt JM; Moguche AO; Siddiqui I; Smigiel KS; Sharma P; Campbell DJ; Way SS; Urdahl KB. 2013. Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12. Immunity 38(6):1261-70. [PubMed: 23791647]  [MGI Ref ID J:207578]

Shang XZ; Ma KY; Radewonuk J; Li J; Song XY; Griswold DE; Emmell E; Li L. 2006. IgE isotype switch and IgE production are enhanced in IL-21-deficient but not IFN-gamma-deficient mice in a Th2-biased response. Cell Immunol 241(2):66-74. [PubMed: 16979605]  [MGI Ref ID J:114783]

Shaw PJ; Ditewig AC; Waring JF; Liguori MJ; Blomme EA; Ganey PE; Roth RA. 2009. Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury. Toxicol Sci 107(1):270-80. [PubMed: 18930950]  [MGI Ref ID J:144560]

Shi FD; Takeda K; Akira S; Sarvetnick N; Ljunggren HG. 2000. IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-gamma by NK cells. J Immunol 165(6):3099-104. [PubMed: 10975822]  [MGI Ref ID J:64550]

Shi FD; Wang HB; Li H; Hong S; Taniguchi M; Link H; Van Kaer L; Ljunggren HG. 2000. Natural killer cells determine the outcome of B cell-mediated autoimmunity. Nat Immunol 1(3):245-51. [PubMed: 10973283]  [MGI Ref ID J:64350]

Shi M; Ye Z; Umeshappa KS; Moyana T; Xiang J. 2007. Alpha tumor necrosis factor contributes to CD8(+) T cell survival in the transition phase. Biochem Biophys Res Commun 360(3):702-7. [PubMed: 17618911]  [MGI Ref ID J:123025]

Shi S; Blumenthal A; Hickey CM; Gandotra S; Levy D; Ehrt S. 2005. Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1. J Immunol 175(5):3318-28. [PubMed: 16116224]  [MGI Ref ID J:113220]

Shi X; Cao S; Mitsuhashi M; Xiang Z; Ma X. 2004. Genome-wide analysis of molecular changes in IL-12-induced control of mammary carcinoma via IFN-gamma-independent mechanisms. J Immunol 172(7):4111-22. [PubMed: 15034023]  [MGI Ref ID J:88715]

Shichita T; Sugiyama Y; Ooboshi H; Sugimori H; Nakagawa R; Takada I; Iwaki T; Okada Y; Iida M; Cua DJ; Iwakura Y; Yoshimura A. 2009. Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury. Nat Med 15(8):946-50. [PubMed: 19648929]  [MGI Ref ID J:152082]

Shimizu K; Asakura M; Fujii S. 2011. Prolonged antitumor NK cell reactivity elicited by CXCL10-expressing dendritic cells licensed by CD40L+ CD4+ memory T cells. J Immunol 186(10):5927-37. [PubMed: 21460206]  [MGI Ref ID J:173107]

Shreiner AB; Murdock BJ; Sadighi Akha AA; Falkowski NR; Christensen PJ; White ES; Hogaboam CM; Huffnagle GB. 2012. Repeated Exposure to Aspergillus fumigatus Conidia Results in CD4+ T Cell-Dependent and -Independent Pulmonary Arterial Remodeling in a Mixed Th1/Th2/Th17 Microenvironment That Requires Interleukin-4 (IL-4) and IL-10. Infect Immun 80(1):388-97. [PubMed: 22064716]  [MGI Ref ID J:179004]

Shurin MR; Potapovich AI; Tyurina YY; Tourkova IL; Shurin GV; Kagan VE. 2009. Recognition of live phosphatidylserine-labeled tumor cells by dendritic cells: a novel approach to immunotherapy of skin cancer. Cancer Res 69(6):2487-96. [PubMed: 19276376]  [MGI Ref ID J:147072]

Siegmund B; Sennello JA; Lehr HA; Senaldi G; Dinarello CA; Fantuzzi G. 2004. Frontline: Interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR gamma delta T cells and interleukin-18-binding protein. Eur J Immunol 34(9):2356-64. [PubMed: 15307168]  [MGI Ref ID J:91767]

Silva NM; Vieira JC; Carneiro CM; Tafuri WL. 2009. Toxoplasma gondii: the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection. Exp Parasitol 123(1):65-72. [PubMed: 19501090]  [MGI Ref ID J:156567]

Silva RA; Pais TF; Appelberg R. 1998. Evaluation of IL-12 in immunotherapy and vaccine design in experimental Mycobacterium avium infections. J Immunol 161(10):5578-85. [PubMed: 9820535]  [MGI Ref ID J:115036]

Simkins HM; Hyde E; Farrand KJ; Ong ML; Degli-Esposti MA; Hermans IF; Ronchese F. 2011. Administration of {alpha}-galactosylceramide impairs the survival of dendritic cell subpopulations in vivo. J Leukoc Biol 89(5):753-62. [PubMed: 21297009]  [MGI Ref ID J:172098]

Simma O; Zebedin E; Neugebauer N; Schellack C; Pilz A; Chang-Rodriguez S; Lingnau K; Weisz E; Putz EM; Pickl WF; Felzmann T; Muller M; Decker T; Sexl V; Stoiber D. 2009. Identification of an indispensable role for tyrosine kinase 2 in CTL-mediated tumor surveillance. Cancer Res 69(1):203-11. [PubMed: 19118004]  [MGI Ref ID J:143032]

Simmons CP; Goncalves NS; Ghaem-Maghami M; Bajaj-Elliott M; Clare S; Neves B; Frankel G; Dougan G; MacDonald TT. 2002. Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma. J Immunol 168(4):1804-12. [PubMed: 11823513]  [MGI Ref ID J:74480]

Simmons CP; Mastroeni P; Fowler R; Ghaem-maghami M; Lycke N; Pizza M; Rappuoli R; Dougan G. 1999. MHC class I-restricted cytotoxic lymphocyte responses induced by enterotoxin-based mucosal adjuvants. J Immunol 163(12):6502-10. [PubMed: 10586042]  [MGI Ref ID J:58977]

Sinha P; Parker KH; Horn L; Ostrand-Rosenberg S. 2012. Tumor-induced myeloid-derived suppressor cell function is independent of IFN-gamma and IL-4Ralpha. Eur J Immunol 42(8):2052-9. [PubMed: 22673957]  [MGI Ref ID J:187851]

Sinha S; Guo Y; Thet S; Yuan D. 2012. IFN type I and type II independent enhancement of B cell TLR7 expression by natural killer cells. J Leukoc Biol 92(4):713-22. [PubMed: 22636319]  [MGI Ref ID J:189565]

Skoberne M; Geginat G. 2002. Efficient in vivo presentation of Listeria monocytogenes- derived CD4 and CD8 T cell epitopes in the absence of IFN-gamma. J Immunol 168(4):1854-60. [PubMed: 11823519]  [MGI Ref ID J:74477]

Skyberg JA; Rollins MF; Samuel JW; Sutherland MD; Belisle JT; Pascual DW. 2013. Interleukin-17 Protects against the Francisella tularensis Live Vaccine Strain but Not against a Virulent F. tularensis Type A Strain. Infect Immun 81(9):3099-105. [PubMed: 23774604]  [MGI Ref ID J:199831]

Skyberg JA; Thornburg T; Kochetkova I; Layton W; Callis G; Rollins MF; Riccardi C; Becker T; Golden S; Pascual DW. 2012. IFN-gamma-deficient mice develop IL-1-dependent cutaneous and musculoskeletal inflammation during experimental brucellosis. J Leukoc Biol 92(2):375-87. [PubMed: 22636321]  [MGI Ref ID J:186167]

Smeltz RB; Chen J; Shevach EM. 2005. Transforming growth factor-beta1 enhances the interferon-gamma-dependent, interleukin-12-independent pathway of T helper 1 cell differentiation. Immunology 114(4):484-92. [PubMed: 15804285]  [MGI Ref ID J:97437]

Smith AL; Hayday AC. 2000. Genetic dissection of primary and secondary responses to a widespread natural pathogen of the gut, Eimeria vermiformis. Infect Immun 68(11):6273-80. [PubMed: 11035735]  [MGI Ref ID J:133107]

Smith LM; Bonafonte MT; Mead JR. 2000. Cytokine expression and specific lymphocyte proliferation in two strains of Cryptosporidium parvum-infected gamma-interferon knockout mice. J Parasitol 86(2):300-7. [PubMed: 10780549]  [MGI Ref ID J:62349]

Smyth MJ; Swann J; Cretney E; Zerafa N; Yokoyama WM; Hayakawa Y. 2005. NKG2D function protects the host from tumor initiation. J Exp Med 202(5):583-8. [PubMed: 16129707]  [MGI Ref ID J:100684]

Smyth MJ; Wallace ME; Nutt SL; Yagita H; Godfrey DI; Hayakawa Y. 2005. Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer. J Exp Med 201(12):1973-85. [PubMed: 15967825]  [MGI Ref ID J:99284]

Smythies LE; Waites KB; Lindsey JR; Harris PR; Ghiara P; Smith PD. 2000. Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice. J Immunol 165(2):1022-9. [PubMed: 10878379]  [MGI Ref ID J:120556]

Sorensen EW; Gerber SA; Frelinger JG; Lord EM. 2010. IL-12 suppresses vascular endothelial growth factor receptor 3 expression on tumor vessels by two distinct IFN-gamma-dependent mechanisms. J Immunol 184(4):1858-66. [PubMed: 20061409]  [MGI Ref ID J:159492]

Souto JT; Figueiredo F; Furlanetto A; Pfeffer K; Rossi MA; Silva JS. 2000. Interferon-gamma and tumor necrosis factor-alpha determine resistance to Paracoccidioides brasiliensis infection in mice. Am J Pathol 156(5):1811-20. [PubMed: 10793093]  [MGI Ref ID J:108248]

Spanier JA; Nashold FE; Olson JK; Hayes CE. 2012. The Ifng gene is essential for Vdr gene expression and vitamin D(3)-mediated reduction of the pathogenic T cell burden in the central nervous system in experimental autoimmune encephalomyelitis, a multiple sclerosis model. J Immunol 189(6):3188-97. [PubMed: 22896638]  [MGI Ref ID J:189942]

Spear P; Barber A; Rynda-Apple A; Sentman CL. 2012. Chimeric antigen receptor T cells shape myeloid cell function within the tumor microenvironment through IFN-gamma and GM-CSF. J Immunol 188(12):6389-98. [PubMed: 22586039]  [MGI Ref ID J:188969]

Spergel JM; Mizoguchi E; Oettgen H; Bhan AK; Geha RS. 1999. Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis. J Clin Invest 103(8):1103-11. [PubMed: 10207161]  [MGI Ref ID J:119611]

St John AL; Abraham SN. 2009. Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines. Nat Med 15(11):1259-65. [PubMed: 19855398]  [MGI Ref ID J:155766]

Staehli F; Ludigs K; Heinz LX; Seguin-Estevez Q; Ferrero I; Braun M; Schroder K; Rebsamen M; Tardivel A; Mattmann C; MacDonald HR; Romero P; Reith W; Guarda G; Tschopp J. 2012. NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells. J Immunol 188(8):3820-8. [PubMed: 22412192]  [MGI Ref ID J:184076]

Stange J; Hepworth MR; Rausch S; Zajic L; Kuhl AA; Uyttenhove C; Renauld JC; Hartmann S; Lucius R. 2012. IL-22 Mediates Host Defense against an Intestinal Intracellular Parasite in the Absence of IFN-gamma at the Cost of Th17-Driven Immunopathology. J Immunol 188(5):2410-8. [PubMed: 22266282]  [MGI Ref ID J:181287]

Starr R; Fuchsberger M; Lau LS; Uldrich AP; Goradia A; Willson TA; Verhagen AM; Alexander WS; Smyth MJ. 2009. SOCS-1 binding to tyrosine 441 of IFN-gamma receptor subunit 1 contributes to the attenuation of IFN-gamma signaling in vivo. J Immunol 183(7):4537-44. [PubMed: 19734231]  [MGI Ref ID J:152785]

Stern ME; Siemasko K; Gao J; Duong A; Beauregard C; Calder V; Niederkorn JY. 2005. Role of interferon-gamma in a mouse model of allergic conjunctivitis. Invest Ophthalmol Vis Sci 46(9):3239-46. [PubMed: 16123425]  [MGI Ref ID J:101339]

Stoermer Burrack KA; Hawman DW; Jupille HJ; Oko L; Minor M; Shives KD; Gunn BM; Long KM; Morrison TE. 2014. Attenuating mutations in nsP1 reveal tissue-specific mechanisms for control of Ross River virus infection. J Virol 88(7):3719-32. [PubMed: 24429363]  [MGI Ref ID J:213015]

Storm P; Bartholdy C; Sorensen MR; Christensen JP; Thomsen AR. 2006. Perforin-deficient CD8+ T cells mediate fatal lymphocytic choriomeningitis despite impaired cytokine production. J Virol 80(3):1222-30. [PubMed: 16414999]  [MGI Ref ID J:153336]

Strbo N; Oizumi S; Sotosek-Tokmadzic V; Podack ER. 2003. Perforin is required for innate and adaptive immunity induced by heat shock protein gp96. Immunity 18(3):381-90. [PubMed: 12648455]  [MGI Ref ID J:82494]

Street SE; Cretney E; Smyth MJ. 2001. Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis. Blood 97(1):192-7. [PubMed: 11133760]  [MGI Ref ID J:68550]

Street SE; Trapani JA; MacGregor D; Smyth MJ. 2002. Suppression of lymphoma and epithelial malignancies effected by interferon gamma. J Exp Med 196(1):129-34. [PubMed: 12093877]  [MGI Ref ID J:77491]

Strutt TM; McKinstry KK; Dibble JP; Winchell C; Kuang Y; Curtis JD; Huston G; Dutton RW; Swain SL. 2010. Memory CD4+ T cells induce innate responses independently of pathogen. Nat Med 16(5):558-64, 1p following 564. [PubMed: 20436484]  [MGI Ref ID J:160609]

Stuller KA; Cush SS; Flano E. 2010. Persistent gamma-herpesvirus infection induces a CD4 T cell response containing functionally distinct effector populations. J Immunol 184(7):3850-6. [PubMed: 20208003]  [MGI Ref ID J:160066]

Su SB; Grajewski RS; Luger D; Agarwal RK; Silver PB; Tang J; Tuo J; Chan CC; Caspi RR. 2007. Altered chemokine profile associated with exacerbated autoimmune pathology under conditions of genetic interferon-gamma deficiency. Invest Ophthalmol Vis Sci 48(10):4616-25. [PubMed: 17898285]  [MGI Ref ID J:126928]

Subleski JJ; Hall VL; Wolfe TB; Scarzello AJ; Weiss JM; Chan T; Hodge DL; Back TC; Ortaldo JR; Wiltrout RH. 2011. TCR-dependent and -independent activation underlie liver-specific regulation of NKT cells. J Immunol 186(2):838-47. [PubMed: 21148802]  [MGI Ref ID J:168779]

Sun J; Dodd H; Moser EK; Sharma R; Braciale TJ. 2011. CD4(+) T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs. Nat Immunol 12(4):327-34. [PubMed: 21297642]  [MGI Ref ID J:170347]

Sun J; Sukhova GK; Wolters PJ; Yang M; Kitamoto S; Libby P; MacFarlane LA; Mallen-St Clair J; Shi GP. 2007. Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med 13(6):719-24. [PubMed: 17546038]  [MGI Ref ID J:125116]

Sun J; Sukhova GK; Yang M; Wolters PJ; MacFarlane LA; Libby P; Sun C; Zhang Y; Liu J; Ennis TL; Knispel R; Xiong W; Thompson RW; Baxter BT; Shi GP. 2007. Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice. J Clin Invest 117(11):3359-68. [PubMed: 17932568]  [MGI Ref ID J:127400]

Sun K; Hsiao HH; Li M; Ames E; Bouchlaka M; Welniak LA; Hagino T; Jagdeo J; Pai CC; Chen M; Blazar BR; Abedi M; Murphy WJ. 2012. IFN-gamma receptor-deficient donor T cells mediate protection from graft-versus-host disease and preserve graft-versus-tumor responses after allogeneic bone marrow transplantation. J Immunol 189(4):2033-42. [PubMed: 22778394]  [MGI Ref ID J:189757]

Sun K; Metzger DW. 2008. Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection. Nat Med 14(5):558-64. [PubMed: 18438414]  [MGI Ref ID J:136669]

Sun K; Ye J; Perez DR; Metzger DW. 2011. Seasonal FluMist vaccination induces cross-reactive T cell immunity against H1N1 (2009) influenza and secondary bacterial infections. J Immunol 186(2):987-93. [PubMed: 21160043]  [MGI Ref ID J:168768]

Sun R; Gao B. 2004. Negative regulation of liver regeneration by innate immunity (natural killer cells/interferon-gamma). Gastroenterology 127(5):1525-39. [PubMed: 15521020]  [MGI Ref ID J:107757]

Sutherland AP; Joller N; Michaud M; Liu SM; Kuchroo VK; Grusby MJ. 2013. IL-21 Promotes CD8+ CTL Activity via the Transcription Factor T-bet. J Immunol 190(8):3977-84. [PubMed: 23479229]  [MGI Ref ID J:194899]

Svensson M; Zubairi S; Maroof A; Kazi F; Taniguchi M; Kaye PM. 2005. Invariant NKT cells are essential for the regulation of hepatic CXCL10 gene expression during Leishmania donovani infection. Infect Immun 73(11):7541-7. [PubMed: 16239557]  [MGI Ref ID J:104288]

Swain SD; Meissner NN; Siemsen DW; McInnerney K; Harmsen AG. 2012. Pneumocystis elicits a STAT6-dependent, strain-specific innate immune response and airway hyperresponsiveness. Am J Respir Cell Mol Biol 46(3):290-8. [PubMed: 21960549]  [MGI Ref ID J:194583]

Swain SD; Siemsen DW; Pullen RR; Han S. 2014. CD4+ T cells and IFN-gamma are required for the development of Pneumocystis-associated pulmonary hypertension. Am J Pathol 184(2):483-93. [PubMed: 24361497]  [MGI Ref ID J:206386]

Swann JB; Vesely MD; Silva A; Sharkey J; Akira S; Schreiber RD; Smyth MJ. 2008. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc Natl Acad Sci U S A 105(2):652-6. [PubMed: 18178624]  [MGI Ref ID J:131026]

Takabayshi K; Corr M; Hayashi T; Redecke V; Beck L; Guiney D; Sheppard D; Raz E. 2006. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity 24(4):475-87. [PubMed: 16618605]  [MGI Ref ID J:113350]

Takahashi H; Kouno M; Nagao K; Wada N; Hata T; Nishimoto S; Iwakura Y; Yoshimura A; Yamada T; Kuwana M; Fujii H; Koyasu S; Amagai M. 2011. Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice. J Clin Invest 121(9):3677-88. [PubMed: 21821914]  [MGI Ref ID J:178257]

Takeda K; Cretney E; Hayakawa Y; Ota T; Akiba H; Ogasawara K; Yagita H; Kinoshita K; Okumura K; Smyth MJ. 2005. TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver. Blood 105(5):2082-9. [PubMed: 15536146]  [MGI Ref ID J:98142]

Takeda K; Nakayama M; Sakaki M; Hayakawa Y; Imawari M; Ogasawara K; Okumura K; Smyth MJ. 2011. IFN-gamma production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice. J Leukoc Biol 90(4):777-85. [PubMed: 21712396]  [MGI Ref ID J:177544]

Takeda K; Smyth MJ; Cretney E; Hayakawa Y; Yamaguchi N; Yagita H; Okumura K. 2001. Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth. Cell Immunol 214(2):194-200. [PubMed: 12088418]  [MGI Ref ID J:76563]

Tanaka K; Ichiyama K; Hashimoto M; Yoshida H; Takimoto T; Takaesu G; Torisu T; Hanada T; Yasukawa H; Fukuyama S; Inoue H; Nakanishi Y; Kobayashi T; Yoshimura A. 2008. Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-{gamma} on STAT3 and Smads. J Immunol 180(6):3746-56. [PubMed: 18322180]  [MGI Ref ID J:132905]

Tang H; Sharp GC; Peterson KP; Braley-Mullen H. 1998. IFN-gamma-deficient mice develop severe granulomatous experimental autoimmune thyroiditis with eosinophil infiltration in thyroids. J Immunol 160(10):5105-12. [PubMed: 9590262]  [MGI Ref ID J:47481]

Tarallo V; Hirano Y; Gelfand BD; Dridi S; Kerur N; Kim Y; Cho WG; Kaneko H; Fowler BJ; Bogdanovich S; Albuquerque RJ; Hauswirth WW; Chiodo VA; Kugel JF; Goodrich JA; Ponicsan SL; Chaudhuri G; Murphy MP; Dunaief JL; Ambati BK; Ogura Y; Yoo JW; Lee DK; Provost P; Hinton DR; Nunez G; Baffi JZ; Kleinman ME; Ambati J. 2012. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell 149(4):847-59. [PubMed: 22541070]  [MGI Ref ID J:186198]

Tarrant TK; Silver PB; Wahlsten JL; Rizzo LV; Chan CC; Wiggert B; Caspi RR. 1999. Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis. J Exp Med 189(2):219-30. [PubMed: 9892605]  [MGI Ref ID J:119614]

Tatum AM; Mylin LM; Bender SJ; Fischer MA; Vigliotti BA; Tevethia MJ; Tevethia SS; Schell TD. 2008. CD8+ T cells targeting a single immunodominant epitope are sufficient for elimination of established SV40 T antigen-induced brain tumors. J Immunol 181(6):4406-17. [PubMed: 18768900]  [MGI Ref ID J:142961]

Taylor AP; Murray HW. 1997. Intracellular antimicrobial activity in the absence of interferon-gamma: effect of interleukin-12 in experimental visceral leishmaniasis in interferon-gamma gene-disrupted mice. J Exp Med 185(7):1231-9. [PubMed: 9104810]  [MGI Ref ID J:40241]

Tchaptchet S; Gumenscheimer M; Kalis C; Freudenberg N; Holscher C; Kirschning CJ; Lamers M; Galanos C; Freudenberg MA. 2012. TLR9-dependent and independent pathways drive activation of the immune system by Propionibacterium acnes. PLoS One 7(6):e39155. [PubMed: 22745710]  [MGI Ref ID J:187937]

Teng MW; Andrews DM; McLaughlin N; von Scheidt B; Ngiow SF; Moller A; Hill GR; Iwakura Y; Oft M; Smyth MJ. 2010. IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis. Proc Natl Acad Sci U S A 107(18):8328-33. [PubMed: 20404142]  [MGI Ref ID J:160332]

Teng MW; von Scheidt B; Duret H; Towne JE; Smyth MJ. 2011. Anti-IL-23 Monoclonal Antibody Synergizes in Combination with Targeted Therapies or IL-2 to Suppress Tumor Growth and Metastases. Cancer Res 71(6):2077-86. [PubMed: 21282337]  [MGI Ref ID J:170103]

Teske S; Bohn AA; Hogaboam JP; Lawrence BP. 2008. Aryl hydrocarbon receptor targets pathways extrinsic to bone marrow cells to enhance neutrophil recruitment during influenza virus infection. Toxicol Sci 102(1):89-99. [PubMed: 18007012]  [MGI Ref ID J:133909]

Tesselaar K; Arens R; van Schijndel GM; Baars PA; van der Valk MA; Borst J; van Oers MH; van Lier RA. 2003. Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions. Nat Immunol 4(1):49-54. [PubMed: 12469117]  [MGI Ref ID J:82292]

Thomas MJ; Noble A; Sawicka E; Askenase PW; Kemeny DM. 2002. CD8 T cells inhibit IgE via dendritic cell IL-12 induction that promotes Th1 T cell counter-regulation. J Immunol 168(1):216-23. [PubMed: 11751965]  [MGI Ref ID J:131005]

Timoshanko JR; Holdsworth SR; Kitching AR; Tipping PG. 2002. IFN-gamma production by intrinsic renal cells and bone marrow-derived cells is required for full expression of crescentic glomerulonephritis in mice. J Immunol 168(8):4135-41. [PubMed: 11937574]  [MGI Ref ID J:125655]

Tishon A; Lewicki H; Rall G; Von Herrath M; Oldstone MB. 1995. An essential role for type 1 interferon-gamma in terminating persistent viral infection. Virology 212(1):244-50. [PubMed: 7676639]  [MGI Ref ID J:110746]

Tongren JE; Corran PH; Jarra W; Langhorne J; Riley EM. 2005. Epitope-specific regulation of immunoglobulin class switching in mice immunized with malarial merozoite surface proteins. Infect Immun 73(12):8119-29. [PubMed: 16299306]  [MGI Ref ID J:104297]

Tran EH; Prince EN; Owens T. 2000. IFN-gamma shapes immune invasion of the central nervous system via regulation of chemokines. J Immunol 164(5):2759-68. [PubMed: 10679118]  [MGI Ref ID J:60605]

Trembleau S; Penna G; Gregori S; Giarratana N; Adorini L. 2003. IL-12 Administration Accelerates Autoimmune Diabetes in Both Wild-Type and IFN-gamma-Deficient Nonobese Diabetic Mice, Revealing Pathogenic and Protective Effects of IL-12-Induced IFN-gamma. J Immunol 170(11):5491-501. [PubMed: 12759426]  [MGI Ref ID J:83456]

Trimnell A; Takagi A; Gupta M; Richie TL; Kappe SH; Wang R. 2009. Genetically attenuated parasite vaccines induce contact-dependent CD8+ T cell killing of Plasmodium yoelii liver stage-infected hepatocytes. J Immunol 183(9):5870-8. [PubMed: 19812194]  [MGI Ref ID J:156626]

Tsai S; Shameli A; Yamanouchi J; Clemente-Casares X; Wang J; Serra P; Yang Y; Medarova Z; Moore A; Santamaria P. 2010. Reversal of autoimmunity by boosting memory-like autoregulatory T cells. Immunity 32(4):568-80. [PubMed: 20381385]  [MGI Ref ID J:179859]

Tu CL; Crumrine DA; Man MQ; Chang W; Elalieh H; You M; Elias PM; Bikle DD. 2012. Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function. J Invest Dermatol 132(10):2350-9. [PubMed: 22622426]  [MGI Ref ID J:189566]

Tu E; Ang DK; Bellingham SA; Hogan TV; Teng MW; Smyth MJ; Hill AF; van Driel IR. 2012. Both IFN-gamma and IL-17 are required for the development of severe autoimmune gastritis. Eur J Immunol 42(10):2574-83. [PubMed: 22777705]  [MGI Ref ID J:188007]

Tu SP; Quante M; Bhagat G; Takaishi S; Cui G; Yang XD; Muthuplani S; Shibata W; Fox JG; Pritchard DM; Wang TC. 2011. IFN-{gamma} Inhibits Gastric Carcinogenesis by Inducing Epithelial Cell Autophagy and T-Cell Apoptosis. Cancer Res 71(12):4247-4259. [PubMed: 21512143]  [MGI Ref ID J:173758]

Tung J; Sant AJ. 2013. Orchestration of CD4 T cell epitope preferences after multipeptide immunization. J Immunol 191(2):764-72. [PubMed: 23772029]  [MGI Ref ID J:204957]

Turner J; Orme IM. 2004. The expression of early resistance to an infection with Mycobacterium tuberculosis by old mice is dependent on IFN type II (IFN-gamma) but not IFN type I. Mech Ageing Dev 125(1):1-9. [PubMed: 14706232]  [MGI Ref ID J:121050]

Turner SJ; Olivas E; Gutierrez A; Diaz G; Doherty PC. 2007. Disregulated influenza A virus-specific CD8+ T cell homeostasis in the absence of IFN-gamma signaling. J Immunol 178(12):7616-22. [PubMed: 17548597]  [MGI Ref ID J:148590]

Tzianabos AO; Holsti MA; Zheng XX; Stucchi AF; Kuchroo VK; Strom TB; Glimcher LH; Cruikshank WW. 2008. Functional Th1 cells are required for surgical adhesion formation in a murine model. J Immunol 180(10):6970-6. [PubMed: 18453619]  [MGI Ref ID J:134863]

Valaperti A; Marty RR; Kania G; Germano D; Mauermann N; Dirnhofer S; Leimenstoll B; Blyszczuk P; Dong C; Mueller C; Hunziker L; Eriksson U. 2008. CD11b+ monocytes abrogate Th17 CD4+ T cell-mediated experimental autoimmune myocarditis. J Immunol 180(4):2686-95. [PubMed: 18250481]  [MGI Ref ID J:131968]

Van Kaer L; Rabacal WA; Scott Algood HM; Parekh VV; Olivares-Villagomez D. 2013. In vitro induction of regulatory CD4+CD8alpha+ T cells by TGF-beta, IL-7 and IFN-gamma. PLoS One 8(7):e67821. [PubMed: 23844100]  [MGI Ref ID J:204307]

Van Uden JH; Tran CH; Carson DA; Raz E. 2001. Type I interferon is required to mount an adaptive response to immunostimulatory DNA. Eur J Immunol 31(11):3281-90. [PubMed: 11745345]  [MGI Ref ID J:72586]

VanLith ML; Kohlgraf KG; Sivinski CL; Tempero RM; Hollingsworth MA. 2002. MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses. Int Immunol 14(8):873-82. [PubMed: 12147624]  [MGI Ref ID J:113544]

Verri WA Jr; Cunha TM; Ferreira SH; Wei X; Leung BP; Fraser A; McInnes IB; Liew FY; Cunha FQ. 2007. IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 production. Eur J Immunol 37(12):3373-80. [PubMed: 17979156]  [MGI Ref ID J:128427]

Verri WA Jr; Cunha TM; Magro DA; Domingues AC; Vieira SM; Souza GR; Liew FY; Ferreira SH; Cunha FQ. 2008. Role of IL-18 in overt pain-like behaviour in mice. Eur J Pharmacol 588(2-3):207-12. [PubMed: 18511039]  [MGI Ref ID J:145658]

Verri WA Jr; Guerrero AT; Fukada SY; Valerio DA; Cunha TM; Xu D; Ferreira SH; Liew FY; Cunha FQ. 2008. IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice. Proc Natl Acad Sci U S A 105(7):2723-8. [PubMed: 18250323]  [MGI Ref ID J:131928]

Villalta SA; Deng B; Rinaldi C; Wehling-Henricks M; Tidball JG. 2011. IFN-gamma promotes muscle damage in the mdx mouse model of Duchenne muscular dystrophy by suppressing M2 macrophage activation and inhibiting muscle cell proliferation. J Immunol 187(10):5419-28. [PubMed: 22013114]  [MGI Ref ID J:179601]

Villarino AV; Gallo E; Abbas AK. 2010. STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms. J Immunol 185(11):6461-71. [PubMed: 20974984]  [MGI Ref ID J:167369]

Villegas-Mendez A; Greig R; Shaw TN; de Souza JB; Gwyer Findlay E; Stumhofer JS; Hafalla JC; Blount DG; Hunter CA; Riley EM; Couper KN. 2012. IFN-gamma-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain. J Immunol 189(2):968-79. [PubMed: 22723523]  [MGI Ref ID J:189794]

Villegas-Mendez A; de Souza JB; Murungi L; Hafalla JC; Shaw TN; Greig R; Riley EM; Couper KN. 2011. Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection. J Immunol 187(6):2885-97. [PubMed: 21880980]  [MGI Ref ID J:179223]

Von Herrath MG; Coon B; Oldstone MB. 1997. Low-affinity cytotoxic T-lymphocytes require IFN-gamma to clear an acute viral infection. Virology 229(2):349-59. [PubMed: 9126248]  [MGI Ref ID J:127684]

Wakil AE; Wang ZE; Ryan JC; Fowell DJ; Locksley RM. 1998. Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development. J Exp Med 188(9):1651-6. [PubMed: 9802977]  [MGI Ref ID J:50765]

Wald O; Weiss ID; Wald H; Shoham H; Bar-Shavit Y; Beider K; Galun E; Weiss L; Flaishon L; Shachar I; Nagler A; Lu B; Gerard C; Gao JL; Mishani E; Farber J; Peled A. 2006. IFN-gamma acts on T cells to induce NK cell mobilization and accumulation in target organs. J Immunol 176(8):4716-29. [PubMed: 16585565]  [MGI Ref ID J:131189]

Walter MJ; Morton JD; Kajiwara N; Agapov E; Holtzman MJ. 2002. Viral induction of a chronic asthma phenotype and genetic segregation from the acute response. J Clin Invest 110(2):165-75. [PubMed: 12122108]  [MGI Ref ID J:120696]

Wang B; Xiong Q; Shi Q; Le X; Xie K. 2001. Genetic disruption of host interferon-gamma drastically enhances the metastasis of pancreatic adenocarcinoma through impaired expression of inducible nitric oxide synthase. Oncogene 20(47):6930-7. [PubMed: 11687972]  [MGI Ref ID J:72687]

Wang C; Xiao M; Liu X; Ni C; Liu J; Erben U; Qin Z. 2013. IFN-gamma-mediated downregulation of LXA4 is necessary for the maintenance of nonresolving inflammation and papilloma persistence. Cancer Res 73(6):1742-51. [PubMed: 23319805]  [MGI Ref ID J:196903]

Wang H; Asavaroengchai W; Yeap BY; Wang MG; Wang S; Sykes M; Yang YG. 2009. Paradoxical effects of IFN-gamma in graft-versus-host disease reflect promotion of lymphohematopoietic graft-versus-host reactions and inhibition of epithelial tissue injury. Blood 113(15):3612-9. [PubMed: 19211507]  [MGI Ref ID J:148289]

Wang J; Cho S; Ueno A; Cheng L; Xu BY; Desrosiers MD; Shi Y; Yang Y. 2008. Ligand-dependent induction of noninflammatory dendritic cells by anergic invariant NKT cells minimizes autoimmune inflammation. J Immunol 181(4):2438-45. [PubMed: 18684934]  [MGI Ref ID J:140188]

Wang L; Yi T; Zhang W; Pardoll DM; Yu H. 2010. IL-17 enhances tumor development in carcinogen-induced skin cancer. Cancer Res 70(24):10112-20. [PubMed: 21159633]  [MGI Ref ID J:167606]

Wang Q; Ma X; Chen Y; Zhang L; Jiang M; Li X; Xiang R; Miao R; Hajjar DP; Duan Y; Han J. 2014. Identification of interferon-gamma as a new molecular target of liver X receptor. Biochem J 459(2):345-54. [PubMed: 24438183]  [MGI Ref ID J:212198]

Wang S; Fan Y; Brunham RC; Yang X. 1999. IFN-gamma knockout mice show Th2-associated delayed-type hypersensitivity and the inflammatory cells fail to localize and control chlamydial infection. Eur J Immunol 29(11):3782-92. [PubMed: 10556835]  [MGI Ref ID J:58372]

Wang W; Milani M; Ostlie N; Okita D; Agarwal RK; Caspi RR; Conti-Fine BM. 2007. C57BL/6 mice genetically deficient in IL-12/IL-23 and IFN-gamma are susceptible to experimental autoimmune myasthenia gravis, suggesting a pathogenic role of non-Th1 cells. J Immunol 178(11):7072-80. [PubMed: 17513756]  [MGI Ref ID J:143019]

Wang Y; Lobigs M; Lee E; Koskinen A; Mullbacher A. 2006. CD8(+) T cell-mediated immune responses in West Nile virus (Sarafend strain) encephalitis are independent of gamma interferon. J Gen Virol 87(Pt 12):3599-609. [PubMed: 17098975]  [MGI Ref ID J:135928]

Wang Z; Hong J; Sun W; Xu G; Li N; Chen X; Liu A; Xu L; Sun B; Zhang JZ. 2006. Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs. J Clin Invest 116(9):2434-41. [PubMed: 16906223]  [MGI Ref ID J:114448]

Wang ZE; Reiner SL; Zheng S; Dalton DK; Locksley RM. 1994. CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major. J Exp Med 179(4):1367-71. [PubMed: 7908325]  [MGI Ref ID J:18801]

Warfield KL; Olinger G; Deal EM; Swenson DL; Bailey M; Negley DL; Hart MK; Bavari S. 2005. Induction of humoral and CD8+ T cell responses are required for protection against lethal Ebola virus infection. J Immunol 175(2):1184-91. [PubMed: 16002721]  [MGI Ref ID J:100701]

Watt SV; Andrews DM; Takeda K; Smyth MJ; Hayakawa Y. 2008. IFN-gamma-dependent recruitment of mature CD27(high) NK cells to lymph nodes primed by dendritic cells. J Immunol 181(8):5323-30. [PubMed: 18832688]  [MGI Ref ID J:140770]

Weber SE; Tian H; Pirofski LA. 2011. CD8+ cells enhance resistance to pulmonary serotype 3 Streptococcus pneumoniae infection in mice. J Immunol 186(1):432-42. [PubMed: 21135172]  [MGI Ref ID J:168003]

Weiss JM; Back TC; Scarzello AJ; Subleski JJ; Hall VL; Stauffer JK; Chen X; Micic D; Alderson K; Murphy WJ; Wiltrout RH. 2009. Successful immunotherapy with IL-2/anti-CD40 induces the chemokine-mediated mitigation of an immunosuppressive tumor microenvironment. Proc Natl Acad Sci U S A 106(46):19455-60. [PubMed: 19892741]  [MGI Ref ID J:154752]

Wendel M; Galani IE; Suri-Payer E; Cerwenka A. 2008. Natural killer cell accumulation in tumors is dependent on IFN-gamma and CXCR3 ligands. Cancer Res 68(20):8437-45. [PubMed: 18922917]  [MGI Ref ID J:140551]

Wensky AK; Furtado GC; Marcondes MC; Chen S; Manfra D; Lira SA; Zagzag D; Lafaille JJ. 2005. IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis. J Immunol 174(3):1416-23. [PubMed: 15661899]  [MGI Ref ID J:110017]

Whitman SC; Ravisankar P; Daugherty A. 2002. Interleukin-18 enhances atherosclerosis in apolipoprotein E(-/-) mice through release of interferon-gamma. Circ Res 90(2):E34-8. [PubMed: 11834721]  [MGI Ref ID J:109710]

Whitmire JK; Benning N; Whitton JL. 2005. Cutting edge: early IFN-gamma signaling directly enhances primary antiviral CD4+ T cell responses. J Immunol 175(9):5624-8. [PubMed: 16237051]  [MGI Ref ID J:119361]

Whitmire JK; Eam B; Benning N; Whitton JL. 2007. Direct interferon-gamma signaling dramatically enhances CD4+ and CD8+ T cell memory. J Immunol 179(2):1190-7. [PubMed: 17617612]  [MGI Ref ID J:149391]

Wickstrum JR; Bokhari SM; Fischer JL; Pinson DM; Yeh HW; Horvat RT; Parmely MJ. 2009. Francisella tularensis induces extensive caspase-3 activation and apoptotic cell death in the tissues of infected mice. Infect Immun 77(11):4827-36. [PubMed: 19703976]  [MGI Ref ID J:154196]

Wieland CW; Florquin S; Pater JM; Weijer S; van der Poll T. 2006. CD4+ cells play a limited role in murine lung infection with Mycobacterium kansasii. Am J Respir Cell Mol Biol 34(2):167-73. [PubMed: 16195537]  [MGI Ref ID J:120194]

Wigginton JM; Lee JK; Wiltrout TA; Alvord WG; Hixon JA; Subleski J; Back TC; Wiltrout RH. 2002. Synergistic engagement of an ineffective endogenous anti-tumor immune response and induction of IFN-gamma and Fas-ligand-dependent tumor eradication by combined administration of IL-18 and IL-2. J Immunol 169(8):4467-74. [PubMed: 12370382]  [MGI Ref ID J:109850]

Wildbaum G; Zohar Y; Karin N. 2010. Antigen-specific CD25- Foxp3- IFN-gamma(high) CD4+ T cells restrain the development of experimental allergic encephalomyelitis by suppressing Th17. Am J Pathol 176(6):2764-75. [PubMed: 20382706]  [MGI Ref ID J:161337]

Williams DM; Grubbs BG; Pack E; Kelly K; Rank RG. 1997. Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis. Infect Immun 65(7):2876-82. [PubMed: 9199462]  [MGI Ref ID J:41109]

Wilson ME; Recker TJ; Rodriguez NE; Young BM; Burnell KK; Streit JA; Kline JN. 2002. The TGF-beta response to Leishmania chagasi in the absence of IL-12. Eur J Immunol 32(12):3556-65. [PubMed: 12516540]  [MGI Ref ID J:80857]

Wilson MS; Madala SK; Ramalingam TR; Gochuico BR; Rosas IO; Cheever AW; Wynn TA. 2010. Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. J Exp Med 207(3):535-52. [PubMed: 20176803]  [MGI Ref ID J:158818]

Wohler JE; Smith SS; Zinn KR; Bullard DC; Barnum SR. 2009. Gammadelta T cells in EAE: early trafficking events and cytokine requirements. Eur J Immunol 39(6):1516-26. [PubMed: 19384874]  [MGI Ref ID J:149481]

Wohlleben G; Erb KJ. 2004. The absence of IFN-gamma leads to increased Th2 responses after influenza A virus infection characterized by an increase in CD4+ but not CD8+ T cells producing IL-4 or IL-5 in the lung. Immunol Lett 95(2):161-6. [PubMed: 15388256]  [MGI Ref ID J:113759]

Wolfe DN; Karanikas AT; Hester SE; Kennett MJ; Harvill ET. 2010. IL-10 induction by Bordetella parapertussis limits a protective IFN-gamma response. J Immunol 184(3):1392-400. [PubMed: 20042578]  [MGI Ref ID J:159527]

Wong N; Fam BC; Cempako GR; Steinberg GR; Walder K; Kay TW; Proietto J; Andrikopoulos S. 2011. Deficiency in Interferon-{gamma} Results in Reduced Body Weight and Better Glucose Tolerance in Mice. Endocrinology 152(10):3690-9. [PubMed: 21791564]  [MGI Ref ID J:177070]

Woodward EA; Prele CM; Nicholson SE; Kolesnik TB; Hart PH. 2010. The anti-inflammatory effects of interleukin-4 are not mediated by suppressor of cytokine signalling-1 (SOCS1). Immunology 131(1):118-27. [PubMed: 20406299]  [MGI Ref ID J:166409]

Woolard MD; Hodge LM; Jones HP; Schoeb TR; Simecka JW. 2004. The upper and lower respiratory tracts differ in their requirement of IFN-gamma and IL-4 in controlling respiratory mycoplasma infection and disease. J Immunol 172(11):6875-83. [PubMed: 15153506]  [MGI Ref ID J:90522]

Woolard MD; Hudig D; Tabor L; Ivey JA; Simecka JW. 2005. NK cells in gamma-interferon-deficient mice suppress lung innate immunity against Mycoplasma spp. Infect Immun 73(10):6742-51. [PubMed: 16177352]  [MGI Ref ID J:104216]

Wu HJ; Ivanov II; Darce J; Hattori K; Shima T; Umesaki Y; Littman DR; Benoist C; Mathis D. 2010. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 32(6):815-27. [PubMed: 20620945]  [MGI Ref ID J:162394]

Wu HJ; Sawaya H; Binstadt B; Brickelmaier M; Blasius A; Gorelik L; Mahmood U; Weissleder R; Carulli J; Benoist C; Mathis D. 2007. Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk. J Exp Med 204(8):1911-22. [PubMed: 17646407]  [MGI Ref ID J:125952]

Wu J; Yang J; Yang K; Wang H; Gorentla B; Shin J; Qiu Y; Que LG; Foster WM; Xia Z; Chi H; Zhong XP. 2014. iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions. J Clin Invest 124(4):1685-98. [PubMed: 24614103]  [MGI Ref ID J:209612]

Wu X; Hou W; Sun S; Bi E; Wang Y; Shi M; Zang J; Dong C; Sun B. 2006. Novel function of IFN-gamma: negative regulation of dendritic cell migration and T cell priming. J Immunol 177(2):934-43. [PubMed: 16818748]  [MGI Ref ID J:134949]

Wuthrich M; Filutowicz HI; Warner T; Klein BS. 2002. Requisite elements in vaccine immunity to Blastomyces dermatitidis: plasticity uncovers vaccine potential in immune-deficient hosts. J Immunol 169(12):6969-76. [PubMed: 12471131]  [MGI Ref ID J:118419]

Wuthrich M; Gern B; Hung CY; Ersland K; Rocco N; Pick-Jacobs J; Galles K; Filutowicz H; Warner T; Evans M; Cole G; Klein B. 2011. Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice. J Clin Invest 121(2):554-68. [PubMed: 21206087]  [MGI Ref ID J:171835]

Xia S; Guo Z; Xu X; Yi H; Wang Q; Cao X. 2008. Hepatic microenvironment programs hematopoietic progenitor differentiation into regulatory dendritic cells, maintaining liver tolerance. Blood 112(8):3175-85. [PubMed: 18669892]  [MGI Ref ID J:140215]

Xia S; Guo Z; Yao Y; Xu X; Yi H; Xia D; Cao X. 2008. Liver stroma enhances activation of TLR3-triggered NK cells through fibronectin. Mol Immunol 45(10):2831-8. [PubMed: 18384880]  [MGI Ref ID J:134496]

Xu S; Han Y; Xu X; Bao Y; Zhang M; Cao X. 2010. IL-17A-producing gammadeltaT cells promote CTL responses against Listeria monocytogenes infection by enhancing dendritic cell cross-presentation. J Immunol 185(10):5879-87. [PubMed: 20956351]  [MGI Ref ID J:165775]

Xu X; Yi H; Guo Z; Qian C; Xia S; Yao Y; Cao X. 2012. Splenic stroma-educated regulatory dendritic cells induce apoptosis of activated CD4 T cells via Fas ligand-enhanced IFN-gamma and nitric oxide. J Immunol 188(3):1168-77. [PubMed: 22205032]  [MGI Ref ID J:180753]

Yamada J; Hamuro J; Fukushima A; Ohteki T; Terai K; Iwakura Y; Yagita H; Kinoshita S. 2009. MHC-matched corneal allograft rejection in an IFN-gamma/IL-17-independent manner in C57BL/6 mice. Invest Ophthalmol Vis Sci 50(5):2139-46. [PubMed: 19136699]  [MGI Ref ID J:151042]

Yamada M; Kubo H; Kobayashi S; Ishizawa K; Sasaki H. 2004. Interferon-gamma: a key contributor to hyperoxia-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol 287(5):L1042-7. [PubMed: 15257986]  [MGI Ref ID J:108148]

Yan Y; Zhang GX; Gran B; Fallarino F; Yu S; Li H; Cullimore ML; Rostami A; Xu H. 2010. IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis. J Immunol 185(10):5953-61. [PubMed: 20944000]  [MGI Ref ID J:165630]

Yang CY; Leung PS; Yang GX; Kenny TP; Zhang W; Coppel R; Norman GL; Ansari AA; Mackay IR; Worman HJ; Gershwin ME. 2012. Epitope-specific anti-nuclear antibodies are expressed in a mouse model of primary biliary cirrhosis and are cytokine-dependent. Clin Exp Immunol 168(3):261-7. [PubMed: 22519587]  [MGI Ref ID J:184866]

Yang MC; Chang CP; Lei HY. 2010. Endothelial cells are damaged by autophagic induction before hepatocytes in Con A-induced acute hepatitis. Int Immunol 22(8):661-70. [PubMed: 20547544]  [MGI Ref ID J:162090]

Yang PL; Althage A; Chung J; Maier H; Wieland S; Isogawa M; Chisari FV. 2010. Immune effectors required for hepatitis B virus clearance. Proc Natl Acad Sci U S A 107(2):798-802. [PubMed: 20080755]  [MGI Ref ID J:156523]

Yang T; Stark P; Janik K; Wigzell H; Rottenberg ME. 2008. SOCS-1 Protects against Chlamydia pneumoniae-Induced Lethal Inflammation but Hampers Effective Bacterial Clearance. J Immunol 180(6):4040-9. [PubMed: 18322213]  [MGI Ref ID J:132932]

Yang Y; Ochando JC; Bromberg JS; Ding Y. 2007. Identification of a distant T-bet enhancer responsive to IL-12/Stat4 and IFNgamma/Stat1 signals. Blood 110(7):2494-500. [PubMed: 17575072]  [MGI Ref ID J:147019]

Yang Y; Weiner J; Liu Y; Smith AJ; Huss DJ; Winger R; Peng H; Cravens PD; Racke MK; Lovett-Racke AE. 2009. T-bet is essential for encephalitogenicity of both Th1 and Th17 cells. J Exp Med 206(7):1549-64. [PubMed: 19546248]  [MGI Ref ID J:150271]

Ye P; Chen W; Wu J; Huang X; Li J; Wang S; Liu Z; Wang G; Yang X; Zhang P; Lv Q; Xia J. 2013. GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency. J Clin Invest 123(5):2317-31. [PubMed: 23585475]  [MGI Ref ID J:201455]

Yi T; Chen Y; Wang L; Du G; Huang D; Zhao D; Johnston H; Young J; Todorov I; Umetsu DT; Chen L; Iwakura Y; Kandeel F; Forman S; Zeng D. 2009. Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease. Blood 114(14):3101-12. [PubMed: 19602708]  [MGI Ref ID J:153264]

Yilmaz G; Arumugam TV; Stokes KY; Granger DN. 2006. Role of T lymphocytes and interferon-gamma in ischemic stroke. Circulation 113(17):2105-12. [PubMed: 16636173]  [MGI Ref ID J:122450]

Yokota N; Burne-Taney M; Racusen L; Rabb H. 2003. Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury. Am J Physiol Renal Physiol 285(2):F319-25. [PubMed: 12709397]  [MGI Ref ID J:84825]

Yu M; Eckart MR; Morgan AA; Mukai K; Butte AJ; Tsai M; Galli SJ. 2011. Identification of an IFN-gamma/mast cell axis in a mouse model of chronic asthma. J Clin Invest 121(8):3133-43. [PubMed: 21737883]  [MGI Ref ID J:176170]

Yu Q; Park JH; Doan LL; Erman B; Feigenbaum L; Singer A. 2006. Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection. J Exp Med 203(1):165-75. [PubMed: 16390939]  [MGI Ref ID J:118814]

Yu Q; Xu M; Sen JM. 2007. Beta-catenin expression enhances IL-7 receptor signaling in thymocytes during positive selection. J Immunol 179(1):126-31. [PubMed: 17579030]  [MGI Ref ID J:149422]

Yu S; Sharp GC; Braley-Mullen H. 2008. TGF-beta promotes thyroid epithelial cell hyperplasia and fibrosis in IFN-gamma-deficient NOD.H-2h4 mice. J Immunol 181(3):2238-45. [PubMed: 18641364]  [MGI Ref ID J:139224]

Yu S; Sharp GC; Braley-Mullen H. 2006. Thyrocytes responding to IFN-gamma are essential for development of lymphocytic spontaneous autoimmune thyroiditis and inhibition of thyrocyte hyperplasia. J Immunol 176(2):1259-65. [PubMed: 16394017]  [MGI Ref ID J:126438]

Yu S; Sharp GC; Braley-Mullen H. 2006. Thyroid epithelial cell hyperplasia in IFN-gamma deficient NOD.H-2h4 mice. Clin Immunol 118(1):92-100. [PubMed: 16150647]  [MGI Ref ID J:107231]

Zand MS; Li Y; Hancock W; Li XC; Roy-Chaudhury P; Zheng XX; Strom TB. 2000. Interleukin-2 and interferon-gamma double knockout mice reject heterotopic cardiac allografts Transplantation 70(9):1378-81. [PubMed: 11087156]  [MGI Ref ID J:65781]

Zehntner SP; Brickman C; Bourbonniere L; Remington L; Caruso M; Owens T. 2005. Neutrophils that infiltrate the central nervous system regulate T cell responses. J Immunol 174(8):5124-31. [PubMed: 15814744]  [MGI Ref ID J:98148]

Zelante T; De Luca A; Bonifazi P; Montagnoli C; Bozza S; Moretti S; Belladonna ML; Vacca C; Conte C; Mosci P; Bistoni F; Puccetti P; Kastelein RA; Kopf M; Romani L. 2007. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur J Immunol 37(10):2695-706. [PubMed: 17899546]  [MGI Ref ID J:125340]

Zeng H; Yang K; Cloer C; Neale G; Vogel P; Chi H. 2013. mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. Nature 499(7459):485-90. [PubMed: 23812589]  [MGI Ref ID J:204754]

Zeng X; Moore TA; Newstead MW; Deng JC; Kunkel SL; Luster AD; Standiford TJ. 2005. Interferon-inducible protein 10, but not monokine induced by gamma interferon, promotes protective type 1 immunity in murine Klebsiella pneumoniae pneumonia. Infect Immun 73(12):8226-36. [PubMed: 16299319]  [MGI Ref ID J:104304]

Zeng XL; Nagavalli A; Smith CJ; Howard JF; Su MA. 2013. Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by aire deficiency. J Immunol 190(8):3895-904. [PubMed: 23487421]  [MGI Ref ID J:194890]

Zhang C; Feng Y; Yang H; Koga H; Teitelbaum DH. 2009. The bone morphogenetic protein signaling pathway is upregulated in a mouse model of total parenteral nutrition. J Nutr 139(7):1315-21. [PubMed: 19498022]  [MGI Ref ID J:150055]

Zhang J; Alcaide P; Liu L; Sun J; He A; Luscinskas FW; Shi GP. 2011. Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils. PLoS One 6(1):e14525. [PubMed: 21264293]  [MGI Ref ID J:169463]

Zhang JG; Metcalf D; Rakar S; Asimakis M; Greenhalgh CJ; Willson TA; Starr R; Nicholson SE; Carter W; Alexander WS; Hilton DJ; Nicola NA. 2001. The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action invivo. Proc Natl Acad Sci U S A 98(23):13261-5. [PubMed: 11606785]  [MGI Ref ID J:72528]

Zhang T; Sentman CL. 2013. Mouse Tumor Vasculature Expresses NKG2D Ligands and Can Be Targeted by Chimeric NKG2D-Modified T Cells. J Immunol 190(5):2455-63. [PubMed: 23355740]  [MGI Ref ID J:193469]

Zhang X; Chen W; De Paiva CS; Corrales RM; Volpe EA; McClellan AJ; Farley WJ; Li DQ; Pflugfelder SC. 2011. Interferon-gamma exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways. Invest Ophthalmol Vis Sci 52(9):6279-85. [PubMed: 21474767]  [MGI Ref ID J:181423]

Zhang X; Chen W; De Paiva CS; Volpe EA; Gandhi NB; Farley WJ; Li DQ; Niederkorn JY; Stern ME; Pflugfelder SC. 2011. Desiccating Stress Induces CD4(+) T-Cell-Mediated Sjogren's Syndrome-Like Corneal Epithelial Apoptosis via Activation of the Extrinsic Apoptotic Pathway by Interferon-gamma. Am J Pathol 179(4):1807-14. [PubMed: 21843497]  [MGI Ref ID J:176297]

Zhang Y; Jones M; McCabe A; Winslow GM; Avram D; Macnamara KC. 2013. MyD88 Signaling in CD4 T Cells Promotes IFN-gamma Production and Hematopoietic Progenitor Cell Expansion in Response to Intracellular Bacterial Infection. J Immunol 190(9):4725-35. [PubMed: 23526822]  [MGI Ref ID J:195524]

Zhou HF; Yan H; Cannon JL; Springer LE; Green JM; Pham CT. 2013. CD43-mediated IFN-gamma production by CD8+ T cells promotes abdominal aortic aneurysm in mice. J Immunol 190(10):5078-85. [PubMed: 23585675]  [MGI Ref ID J:202563]

Zhou P; Miller G; Seder RA. 1998. Factors involved in regulating primary and secondary immunity to infection with Histoplasma capsulatum: TNF-alpha plays a critical role in maintaining secondary immunity in the absence of IFN-gamma. J Immunol 160(3):1359-68. [PubMed: 9570555]  [MGI Ref ID J:123438]

Zhou Q; Gault RA; Kozel TR; Murphy WJ. 2006. Immunomodulation with CD40 stimulation and interleukin-2 protects mice from disseminated cryptococcosis. Infect Immun 74(4):2161-8. [PubMed: 16552046]  [MGI Ref ID J:107399]

Zhou S; Kurt-Jones EA; Cerny AM; Chan M; Bronson RT; Finberg RW. 2009. MyD88 intrinsically regulates CD4 T-cell responses. J Virol 83(4):1625-34. [PubMed: 19052080]  [MGI Ref ID J:153385]

Zhu B; Bando Y; Xiao S; Yang K; Anderson AC; Kuchroo VK; Khoury SJ. 2007. CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis. J Immunol 179(8):5228-37. [PubMed: 17911608]  [MGI Ref ID J:153031]

Zhu PJ; Huang W; Kalikulov D; Yoo JW; Placzek AN; Stoica L; Zhou H; Bell JC; Friedlander MJ; Krnjevic K; Noebels JL; Costa-Mattioli M. 2011. Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-gamma-Mediated Disinhibition. Cell 147(6):1384-96. [PubMed: 22153080]  [MGI Ref ID J:178915]

Zhu Q; Thomson CW; Rosenthal KL; McDermott MR; Collins SM; Gauldie J. 2008. Immunization with adenovirus at the large intestinal mucosa as an effective vaccination strategy against sexually transmitted viral infection. Mucosal Immunol 1(1):78-88. [PubMed: 19079163]  [MGI Ref ID J:191928]

Zhu Y; Zhu G; Luo L; Flies AS; Chen L. 2007. CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype. Blood 109(11):4882-9. [PubMed: 17244673]  [MGI Ref ID J:145439]

Zilocchi C; Stoppacciaro A; Chiodoni C; Parenza M; Terrazzini N; Colombo MP. 1998. Interferon gamma-independent rejection of interleukin 12-transduced carcinoma cells requires CD4+ T cells and Granulocyte/Macrophage colony-stimulating factor. J Exp Med 188(1):133-43. [PubMed: 9653090]  [MGI Ref ID J:115144]

Zimmerer JM; Lesinski GB; Kondadasula SV; Karpa VI; Lehman A; Raychaudhury A; Becknell B; Carson WE 3rd. 2007. IFN-alpha-induced signal transduction, gene expression, and antitumor activity of immune effector cells are negatively regulated by suppressor of cytokine signaling proteins. J Immunol 178(8):4832-45. [PubMed: 17404264]  [MGI Ref ID J:145200]

Zimmerer JM; Pham TA; Sanders VM; Bumgardner GL. 2010. CD8+ T cells negatively regulate IL-4-dependent, IgG1-dominant posttransplant alloantibody production. J Immunol 185(12):7285-92. [PubMed: 21084663]  [MGI Ref ID J:167458]

Zinselmeyer BH; Heydari S; Sacristan C; Nayak D; Cammer M; Herz J; Cheng X; Davis SJ; Dustin ML; McGavern DB. 2013. PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis. J Exp Med 210(4):757-74. [PubMed: 23530125]  [MGI Ref ID J:198217]

Zoller EE; Lykens JE; Terrell CE; Aliberti J; Filipovich AH; Henson PM; Jordan MB. 2011. Hemophagocytosis causes a consumptive anemia of inflammation. J Exp Med 208(6):1203-14. [PubMed: 21624938]  [MGI Ref ID J:176823]

van Den Broek M; Bachmann MF; Kohler G; Barner M; Escher R; Zinkernagel R; Kopf M. 2000. IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-gamma and nitric oxide synthetase 2. J Immunol 164(1):371-8. [PubMed: 10605032]  [MGI Ref ID J:125984]

van Schaik SM; Abbas AK. 2007. Role of T cells in a murine model of Escherichia coli sepsis. Eur J Immunol 37(11):3101-10. [PubMed: 17948264]  [MGI Ref ID J:126313]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX30

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a good breeder.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $134.80Female or MaleHomozygous for Ifngtm1Ts  
4 weeks $134.80Female or MaleHomozygous for Ifngtm1Ts  
5 weeks $134.80Female or MaleHomozygous for Ifngtm1Ts  
6 weeks $140.25Female or MaleHomozygous for Ifngtm1Ts  
7 weeks $145.70Female or MaleHomozygous for Ifngtm1Ts  
8 weeks $151.15Female or MaleHomozygous for Ifngtm1Ts  
Price per Pair (US dollars $)Pair Genotype
$280.50Homozygous for Ifngtm1Ts x Homozygous for Ifngtm1Ts  

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Supply Notes

  • Pair Pricing: Price may vary depending on the age of the males and females available for shipment. The price displayed is for a male and female at six weeks of age.
  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $175.30Female or MaleHomozygous for Ifngtm1Ts  
4 weeks $175.30Female or MaleHomozygous for Ifngtm1Ts  
5 weeks $175.30Female or MaleHomozygous for Ifngtm1Ts  
6 weeks $182.40Female or MaleHomozygous for Ifngtm1Ts  
7 weeks $189.50Female or MaleHomozygous for Ifngtm1Ts  
8 weeks $196.50Female or MaleHomozygous for Ifngtm1Ts  
Price per Pair (US dollars $)Pair Genotype
$364.70Homozygous for Ifngtm1Ts x Homozygous for Ifngtm1Ts  

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Supply Notes

  • Pair Pricing: Price may vary depending on the age of the males and females available for shipment. The price displayed is for a male and female at six weeks of age.
  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Control Information

  Control
   000651 BALB/cJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
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Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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