Strain Name:

B6.129S7-Ifngtm1Ts/J

Stock Number:

002287

Availability:

Level 2

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered Mutant Mice.
Mating SystemHomozygote x Homozygote         (Female x Male)
Specieslaboratory mouse
Background Strain C57BL/6
Donor Strain 129S7 via AB1 ES cell line (+Hprt-bm2)
GenerationN8+2F8 (20-DEC-06)
 
Donating Investigator Timothy Stewart,   no forwarding info

Appearance
black
Related Genotype: a/a

Description
Mice homozygous for the Ifngtm1Ts targeted mutation are viable and fertile. Homozygotes appear normal in a "clean" environment but display reduced macrophage function in response to pathogens. Specifically, macrophages show impaired production of antimicrobial products and reduced expression of MHC II antigens. There is also uncontrollable proliferation of splenocytes from homozygotes in response to mitogens and alloantigens and a reduced resting natural killer cell activity.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Ifngtm1Ts allele
002286   C.129S7(B6)-Ifngtm1Ts/J
002575   NOD.129S7(B6)-Ifngtm1Ts/DvsJ
View Strains carrying   Ifngtm1Ts     (2 strains)

Additional Web Information

Congenic Nomenclature
Genetic Quality Control Annual Report

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Ifngtm1Ts/Ifngtm1Ts

        B6.129S7-Ifngtm1Ts/J
  • immune system phenotype
  • *normal* immune system phenotype (MGI Ref ID J:114783)
    • do not exhibit defects on either IgE isotype switch or IgE production
    • no abnormal response to infection is detected
    • decreased interferon-gamma secretion (MGI Ref ID J:120556)
      • splenocytes fail to produce IFN-gamma in response to H. pylori antigen stimulation
    • decreased interleukin-10 secretion (MGI Ref ID J:120556)
      • splenocytes from Helicobacter pylori infected mice produce 4-fold less IL-10 when cultured in the presence of H. pylori antigen
    • increased NK T cell number (MGI Ref ID J:122801)
      • unlike in wild-type mice, treatment with LPS and DGalN fails to decrease NK T cell numbers
    • increased interleukin-4 secretion (MGI Ref ID J:120556)
      • splenocytes from Helicobacter pylori infected mice produce significantly more IL-4 than splenocytes from wild-type controls when cultured in the presence of H. pylori antigen
    • stomach inflammation (MGI Ref ID J:120556)
      • 5 weeks after Helicobacter pylori infection, mice have a significantly decreased gastritis inflammation score compared to infected wild-type mice
  • cellular phenotype
  • abnormal redox activity (MGI Ref ID J:122801)
    • unlike in wild-type mice, treatment with LPS and DGalN or TNF-alpha and interferon-gamma fails to increase the production of reactive oxygen species in hepatocytes
  • hematopoietic system phenotype
  • increased NK T cell number (MGI Ref ID J:122801)
    • unlike in wild-type mice, treatment with LPS and DGalN fails to decrease NK T cell numbers
  • homeostasis/metabolism phenotype
  • abnormal nitric oxide homeostasis (MGI Ref ID J:122801)
    • unlike in wild-type mice, treatment with LPS and DGalN fails to increase nitric oxide levels
  • digestive/alimentary phenotype
  • stomach inflammation (MGI Ref ID J:120556)
    • 5 weeks after Helicobacter pylori infection, mice have a significantly decreased gastritis inflammation score compared to infected wild-type mice

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Ifngtm1Ts/Ifngtm1Ts

        involves: 129S7/SvEvBrd * C57BL/6
  • immune system phenotype
  • abnormal NK cell physiology (MGI Ref ID J:66802)
    • significantly lower resting splenic NK cell activity
  • abnormal macrophage physiology (MGI Ref ID J:66802)
    • macrophages from BCG infected mice fail to produce nitric oxide in response to LPS challenge
    • macrophages from BCG infected mice exhibit reduced production of superoxide anion in response to PMA challenge
    • abnormal MHC II cell surface expression on macrophages (MGI Ref ID J:66802)
      • macrophages from BCG infected mice exhibit reduced class II expression
  • increased susceptibility to bacterial infection (MGI Ref ID J:66802)
    • increased mortality following a sublethal dose of Mycobacterium bovis (BCG )
  • cellular phenotype
  • increased cell proliferation (MGI Ref ID J:66802)
    • splenocytes from BCG infected mice exhibit increased proliferation in response to Con A

Ifngtm1Ts/Ifngtm1Ts

        involves: 129S7/SvEvBrd
  • vision/eye phenotype
  • corneal vascularization (MGI Ref ID J:114973)
    • corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice
  • immune system phenotype
  • increased interleukin-17 secretion (MGI Ref ID J:132905)
    • following culturing of IL-17 producing T cells in vitro, IL-17 production is twice as high as in similarly treated wild-type cells
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Ifngtm1Ts related

Cancer Research
Growth Factors/Receptors/Cytokines

Hematological Research
Immunological Defects

Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines
Immunodeficiency (multiple immune defects)
Inflammation

Genes & Alleles

Gene & Allele Information

Allele Symbol Ifngtm1Ts
Allele Name targeted mutation 1, Timothy Stewart
Allele Type Targeted (knock-out)
Common Name(s) IFN-g KO; IFN-gamma KO; IFN-gamma-; IFN-gammatm1Ts; IFN-gammaKO; IFNgamma KO; IFNgamma-; Ifn-gtm1Ts; Ifngtm1Ts; Ifngtm1Ts; gko; ifgtm1; ifntm1Ts; ifng-;
Mutation Made By Timothy Stewart,   no forwarding info
Strain of Origin129S7/SvEvBrd-Hprt1<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt1<+>
Gene Symbol and Name Ifng, interferon gamma
Chromosome 10
Gene Common Name(s) IFG; IFI; IFN-gamma; IFNG2; Ifg;
Molecular Note Insertion of a neomycin gene into exon 2, which introduced a termination codon after the first 30 amino acids of the mature protein. [MGI Ref ID J:66802]

Genotyping

Genotyping Information

Genotyping Protocols

Ifngtm1Ts, STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Dalton DK; Pitts-Meek S; Keshav S; Figari IS; Bradley A; Stewart TA. 1993. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes [see comments] Science 259(5102):1739-42. [PubMed: 8456300]  [MGI Ref ID J:66802]

Additional References

Alcaide P; Fresno M. 2004. The Trypanosoma cruzi membrane mucin AgC10 inhibits T cell activation and IL-2 transcription through L-selectin. Int Immunol 16(10):1365-75. [PubMed: 15314038]  [MGI Ref ID J:93640]

Amiri P; Haak-Frendscho M; Robbins K; McKerrow JH; Stewart T; Jardieu P. 1994. Anti-immunoglobulin E treatment decreases worm burden and egg production in Schistosoma mansoni-infected normal and interferon gamma knockout mice. J Exp Med 180(1):43-51. [PubMed: 8006599]  [MGI Ref ID J:18740]

Arantes RM; Marche HH; Bahia MT; Cunha FQ; Rossi MA; Silva JS. 2004. Interferon-gamma-induced nitric oxide causes intrinsic intestinal denervation in Trypanosoma cruzi-infected mice. Am J Pathol 164(4):1361-8. [PubMed: 15039223]  [MGI Ref ID J:89108]

Bullen DV; Darwiche R; Metcalf D; Handman E; Alexander WS. 2001. Neutralization of interferon-gamma in neonatal SOCS1-/- mice prevents fatty degeneration of the liver but not subsequent fatal inflammatory disease. Immunology 104(1):92-8. [PubMed: 11576226]  [MGI Ref ID J:71691]

Campos MA; Closel M; Valente EP; Cardoso JE; Akira S; Alvarez-Leite JI; Ropert C; Gazzinelli RT. 2004. Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88. J Immunol 172(3):1711-8. [PubMed: 14734753]  [MGI Ref ID J:87693]

Chan WC; Duong TT; Yeung RS. 2004. Presence of IFN-gamma does not indicate its necessity for induction of coronary arteritis in an animal model of Kawasaki disease. J Immunol 173(5):3492-503. [PubMed: 15322214]  [MGI Ref ID J:92708]

Christensen JE; Wodarz D; Christensen JP; Thomsen AR. 2004. Perforin and IFN-gamma do not significantly regulate the virus-specific CD8+ T cell response in the absence of antiviral effector activity. Eur J Immunol 34(5):1389-94. [PubMed: 15114672]  [MGI Ref ID J:89390]

Cooper AM; Dalton DK; Stewart TA; Griffin JP; Russell DG; Orme IM. 1993. Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med 178(6):2243-7. [PubMed: 8245795]  [MGI Ref ID J:15723]

Dohi T; Fujihashi K; Kiyono H; Elson CO; McGhee JR. 2000. Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis. Gastroenterology 119(3):724-33. [PubMed: 10982767]  [MGI Ref ID J:64230]

Feng CG; Collazo-Custodio CM; Eckhaus M; Hieny S; Belkaid Y; Elkins K; Jankovic D; Taylor GA; Sher A. 2004. Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia. J Immunol 172(2):1163-8. [PubMed: 14707092]  [MGI Ref ID J:87364]

Fujigaki S; Saito K; Sekikawa K; Tone S; Takikawa O; Fujii H; Wada H; Noma A; Seishima M. 2001. Lipopolysaccharide induction of indoleamine 2,3-dioxygenase is mediated dominantly by an IFN-gamma-independent mechanism. Eur J Immunol 31(8):2313-8. [PubMed: 11477543]  [MGI Ref ID J:71158]

Hanada T; Yoshida H; Kato S; Tanaka K; Masutani K; Tsukada J; Nomura Y; Mimata H; Kubo M; Yoshimura A. 2003. Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity 19(3):437-50. [PubMed: 14499118]  [MGI Ref ID J:85811]

Hu C; Mayadas-Norton T; Tanaka K; Chan J; Salgame P. 2000. Mycobacterium tuberculosis infection in complement receptor 3-deficient mice. J Immunol 165(5):2596-602. [PubMed: 10946287]  [MGI Ref ID J:64055]

Kemp RA; Ronchese F. 2001. Tumor-specific tc1, but not tc2, cells deliver protective antitumor immunity. J Immunol 167(11):6497-502. [PubMed: 11714817]  [MGI Ref ID J:72797]

Lambert SL; Okada CY; Levy R. 2004. TCR vaccines against a murine T cell lymphoma: a primary role for antibodies of the IgG2c class in tumor protection. J Immunol 172(2):929-36. [PubMed: 14707065]  [MGI Ref ID J:87361]

Metcalf D; Alexander WS; Ryan PJ; Mifsud S; Di Rago L. 2001. Production of colony-stimulating factors and il-5 by organs from three types of mice with inflammatory disease due to loss of the suppressor of cytokine signaling-1. J Immunol 167(8):4661-7. [PubMed: 11591796]  [MGI Ref ID J:72058]

Murphy EA; Sathiyaseelan J; Parent MA; Zou B; Baldwin CL. 2001. Interferon-gamma is crucial for surviving a Brucella abortus infection in both resistant C57BL/6 and susceptible BALB/c mice. Immunology 103(4):511-8. [PubMed: 11529943]  [MGI Ref ID J:71148]

Murray HW; Lu CM; Brooks EB; Fichtl RE; DeVecchio JL; Heinzel FP. 2003. Modulation of T-cell costimulation as immunotherapy or immunochemotherapy in experimental visceral leishmaniasis. Infect Immun 71(11):6453-62. [PubMed: 14573667]  [MGI Ref ID J:86275]

Nance S; Cross R; Fitzpatrick E. 2004. Chemokine production during hypersensitivity pneumonitis. Eur J Immunol 34(3):677-85. [PubMed: 14991597]  [MGI Ref ID J:88361]

Nansen A; Marker O; Bartholdy C; Thomsen AR. 2000. CCR2+ and CCR5+ CD8+ T cells increase during viral infection and migrate to sites of infection. Eur J Immunol 30(7):1797-806. [PubMed: 10940868]  [MGI Ref ID J:63499]

Nguyen HH; van Ginkel FW; Vu HL; Novak MJ; McGhee JR; Mestecky J. 2000. Gamma interferon is not required for mucosal cytotoxic T-lymphocyte responses or heterosubtypic immunity to influenza A virus infection in mice. J Virol 74(12):5495-501. [PubMed: 10823854]  [MGI Ref ID J:62303]

Okamoto M; Kato S; Oizumi K; Kinoshita M; Inoue Y; Hoshino K; Akira S; McKenzie AN; Young HA; Hoshino T. 2002. Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia. Blood 99(4):1289-98. [PubMed: 11830478]  [MGI Ref ID J:74714]

Ponomarev ED; Novikova M; Yassai M; Szczepanik M; Gorski J; Dittel BN. 2004. Gamma delta T cell regulation of IFN-gamma production by central nervous system-infiltrating encephalitogenic T cells: correlation with recovery from experimental autoimmune encephalomyelitis. J Immunol 173(3):1587-95. [PubMed: 15265886]  [MGI Ref ID J:92038]

Scott MJ; Hoth JJ; Stagner MK; Gardner SA; Peyton JC; Cheadle WG. 2004. CD40-CD154 interactions between macrophages and natural killer cells during sepsis are critical for macrophage activation and are not interferon gamma dependent. Clin Exp Immunol 137(3):469-77. [PubMed: 15320895]  [MGI Ref ID J:92312]

Siegmund B; Sennello JA; Lehr HA; Senaldi G; Dinarello CA; Fantuzzi G. 2004. Frontline: Interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR gamma delta T cells and interleukin-18-binding protein. Eur J Immunol 34(9):2356-64. [PubMed: 15307168]  [MGI Ref ID J:91767]

Smith LM; Bonafonte MT; Mead JR. 2000. Cytokine expression and specific lymphocyte proliferation in two strains of Cryptosporidium parvum-infected gamma-interferon knockout mice. J Parasitol 86(2):300-7. [PubMed: 10780549]  [MGI Ref ID J:62349]

Townsend MJ; Weinmann AS; Matsuda JL; Salomon R; Farnham PJ; Biron CA; Gapin L; Glimcher LH. 2004. T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity 20(4):477-94. [PubMed: 15084276]  [MGI Ref ID J:89776]

Van Uden JH; Tran CH; Carson DA; Raz E. 2001. Type I interferon is required to mount an adaptive response to immunostimulatory DNA. Eur J Immunol 31(11):3281-90. [PubMed: 11745345]  [MGI Ref ID J:72586]

Wilson ME; Recker TJ; Rodriguez NE; Young BM; Burnell KK; Streit JA; Kline JN. 2002. The TGF-beta response to Leishmania chagasi in the absence of IL-12. Eur J Immunol 32(12):3556-65. [PubMed: 12516540]  [MGI Ref ID J:80857]

Ifngtm1Ts related

Abromson-Leeman S; Bronson R; Luo Y; Berman M; Leeman R; Leeman J; Dorf M. 2004. T-cell properties determine disease site, clinical presentation, and cellular pathology of experimental autoimmune encephalomyelitis. Am J Pathol 165(5):1519-33. [PubMed: 15509523]  [MGI Ref ID J:109724]

Abromson-Leeman S; Ladell DS; Bronson RT; Dorf ME. 2007. Heterogeneity of EAE mediated by multiple distinct T-effector subsets. J Neuroimmunol 192(1-2):3-12. [PubMed: 17976744]  [MGI Ref ID J:128953]

Adams B; Nagy N; Paulart F; Vanderhaeghen ML; Goldman M; Flamand V. 2003. CD8+ T lymphocytes regulating Th2 pathology escape neonatal tolerization. J Immunol 171(10):5071-6. [PubMed: 14607904]  [MGI Ref ID J:117990]

Afanasyeva M; Georgakopoulos D; Belardi DF; Bedja D; Fairweather D; Wang Y; Kaya Z; Gabrielson KL; Rodriguez ER; Caturegli P; Kass DA; Rose NR. 2005. Impaired up-regulation of CD25 on CD4+ T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart failure. Proc Natl Acad Sci U S A 102(1):180-5. [PubMed: 15611472]  [MGI Ref ID J:95757]

Aguilar PV; Paessler S; Carrara AS; Baron S; Poast J; Wang E; Moncayo AC; Anishchenko M; Watts D; Tesh RB; Weaver SC. 2005. Variation in interferon sensitivity and induction among strains of eastern equine encephalitis virus. J Virol 79(17):11300-10. [PubMed: 16103182]  [MGI Ref ID J:101624]

Akhiani AA; Pappo J; Kabok Z; Schon K; Gao W; Franzen LE; Lycke N. 2002. Protection against Helicobacter pylori infection following immunization is IL-12-dependent and mediated by Th1 cells. J Immunol 169(12):6977-84. [PubMed: 12471132]  [MGI Ref ID J:118009]

Alexander WS; Starr R; Fenner JE; Scott CL; Handman E; Sprigg NS; Corbin JE; Cornish AL; Darwiche R; Owczarek CM; Kay TW; Nicola NA; Hertzog PJ; Metcalf D; Hilton DJ. 1999. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98(5):597-608. [PubMed: 10490099]  [MGI Ref ID J:57474]

Aliberti JC; Souto JT; Marino AP; Lannes-Vieira J; Teixeira MM; Farber J; Gazzinelli RT; Silva JS. 2001. Modulation of chemokine production and inflammatory responses in interferon-gamma- and tumor necrosis factor-R1-deficient mice during Trypanosoma cruzi infection. Am J Pathol 158(4):1433-40. [PubMed: 11290561]  [MGI Ref ID J:68668]

Aly S; Laskay T; Mages J; Malzan A; Lang R; Ehlers S. 2007. Interferon-gamma-dependent mechanisms of mycobacteria-induced pulmonary immunopathology: the role of angiostasis and CXCR3-targeted chemokines for granuloma necrosis. J Pathol 212(3):295-305. [PubMed: 17534845]  [MGI Ref ID J:122272]

Ambati BK; Nozaki M; Singh N; Takeda A; Jani PD; Suthar T; Albuquerque RJ; Richter E; Sakurai E; Newcomb MT; Kleinman ME; Caldwell RB; Lin Q; Ogura Y; Orecchia A; Samuelson DA; Agnew DW; St Leger J; Green WR; Mahasreshti PJ; Curiel DT; Kwan D; Marsh H; Ikeda S; Leiper LJ; Collinson JM; Bogdanovich S; Khurana TS; Shibuya M; Baldwin ME; Ferrara N; Gerber HP; De Falco S; Witta J; Baffi JZ; Raisler BJ; Ambati J. 2006. Corneal avascularity is due to soluble VEGF receptor-1. Nature 443(7114):993-7. [PubMed: 17051153]  [MGI Ref ID J:114973]

Amiri P; Haak-Frendscho M; Robbins K; McKerrow JH; Stewart T; Jardieu P. 1994. Anti-immunoglobulin E treatment decreases worm burden and egg production in Schistosoma mansoni-infected normal and interferon gamma knockout mice. J Exp Med 180(1):43-51. [PubMed: 8006599]  [MGI Ref ID J:18740]

Andersen C; Jensen T; Nansen A; Marker O; Thomsen AR. 1999. CD4(+) T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-gamma or IL-4. Int Immunol 11(12):2035-42. [PubMed: 10590269]  [MGI Ref ID J:110491]

Andoh A; Masuda A; Kumazawa Y; Kasajima T. 2002. Serum antibody response and nasal lymphoid tissue (NALT) structure in the absence of IL-4 or IFN-gamma. Cytokine 20(3):107-12. [PubMed: 12453468]  [MGI Ref ID J:102594]

Andoh A; Masuda A; Yamakawa M; Kumazawa Y; Kasajima T. 2000. Absence of interleukin-4 enhances germinal center reaction in secondary immune response. Immunol Lett 73(1):35-41. [PubMed: 10963809]  [MGI Ref ID J:110473]

Andoh M; Zhang G; Russell-Lodrigue KE; Shive HR; Weeks BR; Samuel JE. 2007. T Cells Are Essential for Bacterial Clearance, and Gamma Interferon, Tumor Necrosis Factor Alpha, and B Cells Are Crucial for Disease Development in Coxiella burnetii Infection in Mice. Infect Immun 75(7):3245-55. [PubMed: 17438029]  [MGI Ref ID J:122426]

Andrade RM; Portillo JA; Wessendarp M; Subauste CS. 2005. CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates. Infect Immun 73(5):3115-23. [PubMed: 15845519]  [MGI Ref ID J:97614]

Andreasen SO; Christensen JE; Marker O; Thomsen AR. 2000. Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8+ effector T cell responses. J Immunol 164(7):3689-97. [PubMed: 10725727]  [MGI Ref ID J:123023]

Arantes RM; Marche HH; Bahia MT; Cunha FQ; Rossi MA; Silva JS. 2004. Interferon-gamma-induced nitric oxide causes intrinsic intestinal denervation in Trypanosoma cruzi-infected mice. Am J Pathol 164(4):1361-8. [PubMed: 15039223]  [MGI Ref ID J:89108]

Arens R; Baars PA; Jak M; Tesselaar K; van der Valk M; van Oers MH; van Lier RA. 2005. Cutting edge: CD95 maintains effector T cell homeostasis in chronic immune activation. J Immunol 174(10):5915-20. [PubMed: 15879081]  [MGI Ref ID J:98994]

Arens R; Nolte MA; Tesselaar K; Heemskerk B; Reedquist KA; van Lier RA; van Oers MH. 2004. Signaling through CD70 regulates B cell activation and IgG production. J Immunol 173(6):3901-8. [PubMed: 15356138]  [MGI Ref ID J:92744]

Arora S; Hernandez Y; Erb-Downward JR; McDonald RA; Toews GB; Huffnagle GB. 2005. Role of IFN-gamma in regulating T2 immunity and the development of alternatively activated macrophages during allergic bronchopulmonary mycosis. J Immunol 174(10):6346-56. [PubMed: 15879135]  [MGI Ref ID J:99045]

Arsenijevic D; Clavel S; Sanchis D; Plamondon J; Huang Q; Ricquier D; Rouger L; Richard D. 2007. Induction of Ucp2 expression in brain phagocytes and neurons following murine toxoplasmosis: an essential role of IFN-gamma and an association with negative energy balance. J Neuroimmunol 186(1-2):121-32. [PubMed: 17467814]  [MGI Ref ID J:124552]

Artis D; Villarino A; Silverman M; He W; Thornton EM; Mu S; Summer S; Covey TM; Huang E; Yoshida H; Koretzky G; Goldschmidt M; Wu GD; de Sauvage F; Miller HR; Saris CJ; Scott P; Hunter CA. 2004. The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. J Immunol 173(9):5626-34. [PubMed: 15494513]  [MGI Ref ID J:93739]

Ashkar AA; Croy BA. 1999. Interferon-gamma contributes to the normalcy of murine pregnancy. Biol Reprod 61(2):493-502. [PubMed: 10411532]  [MGI Ref ID J:56503]

Ashkar AA; Di Santo JP; Croy BA. 2000. Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy [see comments] J Exp Med 192(2):259-70. [PubMed: 10899912]  [MGI Ref ID J:63645]

Badovinac VP; Harty JT. 2000. Adaptive immunity and enhanced CD8+ T cell response to Listeria monocytogenes in the absence of perforin and IFN-gamma. J Immunol 164(12):6444-52. [PubMed: 10843700]  [MGI Ref ID J:83175]

Badovinac VP; Tvinnereim AR; Harty JT. 2000. Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma. Science 290(5495):1354-8. [PubMed: 11082062]  [MGI Ref ID J:83176]

Bai Y; Liu R; Huang D; La Cava A; Tang YY; Iwakura Y; Campagnolo DI; Vollmer TL; Ransohoff RM; Shi FD. 2008. CCL2 recruitment of IL-6-producing CD11b(+) monocytes to the draining lymph nodes during the initiation of Th17-dependent B cell-mediated autoimmunity. Eur J Immunol 38(7):1877-88. [PubMed: 18581322]  [MGI Ref ID J:137386]

Balish E; Wagner RD; Vazquez-Torres A; Pierson C; Warner T. 1998. Candidiasis in interferon-gamma knockout (IFN-gamma-/-) mice. J Infect Dis 178(2):478-87. [PubMed: 9697730]  [MGI Ref ID J:120514]

Balomenos D; Rumold R; Theofilopoulos AN. 1998. Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J Clin Invest 101(2):364-71. [PubMed: 9435308]  [MGI Ref ID J:45391]

Bao S; Beagley KW; France MP; Shen J; Husband AJ. 2000. Interferon-gamma plays a critical role in intestinal immunity against Salmonella typhimurium infection. Immunology 99(3):464-72. [PubMed: 10712678]  [MGI Ref ID J:61050]

Barber EM; Fazzari M; Pollard JW. 2005. Th1 cytokines are essential for placental immunity to Listeria monocytogenes. Infect Immun 73(10):6322-31. [PubMed: 16177303]  [MGI Ref ID J:104232]

Bartholdy C; Nansen A; Christensen JE; Marker O; Thomsen AR. 1999. Inducible nitric-oxide synthase plays a minimal role in lymphocytic choriomeningitis virus-induced, T cell-mediated protective immunity and immunopathology. J Gen Virol 80(Pt 11):2997-3005. [PubMed: 10580062]  [MGI Ref ID J:103345]

Bastos KR; de Deus Vieira de Moraes L; Zago CA; Marinho CR; Russo M; Alvarez JM; D'Imperio Lima MR. 2005. Analysis of the activation profile of dendritic cells derived from the bone marrow of interleukin-12/interleukin-23-deficient mice. Immunology 114(4):499-506. [PubMed: 15804287]  [MGI Ref ID J:97435]

Batchelder JM; Burns JM Jr; Cigel FK; Lieberg H; Manning DD; Pepper BJ; Yanez DM; van der Heyde H; Weidanz WP. 2003. Plasmodium chabaudi adami: interferon-gamma but not IL-2 is essential for the expression of cell-mediated immunity against blood-stage parasites in mice. Exp Parasitol 105(2):159-66. [PubMed: 14969693]  [MGI Ref ID J:102606]

Bergmann CC; Parra B; Hinton DR; Chandran R; Morrison M; Stohlman SA. 2003. Perforin-mediated effector function within the central nervous system requires IFN-gamma-mediated MHC up-regulation. J Immunol 170(6):3204-13. [PubMed: 12626579]  [MGI Ref ID J:126219]

Berner V; Liu H; Zhou Q; Alderson KL; Sun K; Weiss JM; Back TC; Longo DL; Blazar BR; Wiltrout RH; Welniak LA; Redelman D; Murphy WJ. 2007. IFN-gamma mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy. Nat Med 13(3):354-60. [PubMed: 17334371]  [MGI Ref ID J:121706]

Betts G; Twohig J; Van den Broek M; Sierro S; Godkin A; Gallimore A. 2007. The impact of regulatory T cells on carcinogen-induced sarcogenesis. Br J Cancer 96(12):1849-54. [PubMed: 17565340]  [MGI Ref ID J:122744]

Bishop DK; Chan Wood S; Eichwald EJ; Orosz CG. 2001. Immunobiology of allograft rejection in the absence of IFN-gamma: CD8+ effector cells develop independently of CD4+ cells and CD40-CD40 ligand interactions. J Immunol 166(5):3248-55. [PubMed: 11207279]  [MGI Ref ID J:126479]

Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. [PubMed: 15153508]  [MGI Ref ID J:90518]

Bitsaktsis C; Nandi B; Racine R; MacNamara KC; Winslow G. 2007. T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection. Infect Immun 75(10):4933-41. [PubMed: 17664264]  [MGI Ref ID J:125283]

Blais ME; Brochu S; Giroux M; Belanger MP; Dulude G; Sekaly RP; Perreault C. 2008. Why T cells of thymic versus extrathymic origin are functionally different. J Immunol 180(4):2299-312. [PubMed: 18250439]  [MGI Ref ID J:131997]

Blazar BR; Carreno BM; Panoskaltsis-Mortari A; Carter L; Iwai Y; Yagita H; Nishimura H; Taylor PA. 2003. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J Immunol 171(3):1272-7. [PubMed: 12874215]  [MGI Ref ID J:120213]

Blazar BR; Lees CJ; Martin PJ; Noelle RJ; Kwon B; Murphy W; Taylor PA. 2000. Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions. J Immunol 165(9):4901-9. [PubMed: 11046015]  [MGI Ref ID J:118027]

Blohm U; Potthoff D; van der Kogel AJ; Pircher H. 2006. Solid tumors 'melt' from the inside after successful CD8 T cell attack. Eur J Immunol 36(2):468-77. [PubMed: 16385625]  [MGI Ref ID J:113858]

Bokhari SM; Kim KJ; Pinson DM; Slusser J; Yeh HW; Parmely MJ. 2008. NK cells and gamma interferon coordinate the formation and function of hepatic granulomas in mice infected with the Francisella tularensis live vaccine strain. Infect Immun 76(4):1379-89. [PubMed: 18227174]  [MGI Ref ID J:133531]

Borjesson DL; Simon SI; Hodzic E; Ballantyne CM; Barthold SW. 2002. Kinetics of CD11b/CD18 up-regulation during infection with the agent of human granulocytic ehrlichiosis in mice. Lab Invest 82(3):303-11. [PubMed: 11896209]  [MGI Ref ID J:75433]

Bouley DM; Kanangat S; Wire W; Rouse BT. 1995. Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-gamma knockout mice. J Immunol 155(8):3964-71. [PubMed: 7561104]  [MGI Ref ID J:29170]

Bour-Jordan H; Thompson HL; Bluestone JA. 2005. Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice. J Immunol 175(9):5649-55. [PubMed: 16237054]  [MGI Ref ID J:119359]

Brandl K; Plitas G; Schnabl B; DeMatteo RP; Pamer EG. 2007. MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. J Exp Med 204(8):1891-900. [PubMed: 17635956]  [MGI Ref ID J:125955]

Bregenholt S; Berche P; Brombacher F; Di Santo JP. 2001. Conventional alpha beta T cells are sufficient for innate and adaptive immunity against enteric Listeria monocytogenes. J Immunol 166(3):1871-6. [PubMed: 11160234]  [MGI Ref ID J:127008]

Brown DM; Dilzer AM; Meents DL; Swain SL. 2006. CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch. J Immunol 177(5):2888-98. [PubMed: 16920924]  [MGI Ref ID J:139502]

Bry L; Brigl M; Brenner MB. 2006. CD4+-T-cell effector functions and costimulatory requirements essential for surviving mucosal infection with Citrobacter rodentium. Infect Immun 74(1):673-81. [PubMed: 16369024]  [MGI Ref ID J:104251]

Buchanan RM; Arulanandam BP; Metzger DW. 1998. IL-12 enhances antibody responses to T-independent polysaccharide vaccines in the absence of T and NK cells. J Immunol 161(10):5525-33. [PubMed: 9820529]  [MGI Ref ID J:115023]

Buhtoiarov IN; Lum HD; Berke G; Sondel PM; Rakhmilevich AL. 2006. Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects. J Immunol 176(1):309-18. [PubMed: 16365423]  [MGI Ref ID J:126263]

Buhtoiarov IN; Sondel PM; Eickhoff JC; Rakhmilevich AL. 2007. Macrophages are essential for antitumour effects against weakly immunogenic murine tumours induced by class B CpG-oligodeoxynucleotides. Immunology 120(3):412-23. [PubMed: 17163960]  [MGI Ref ID J:122619]

Bullen DV; Baldwin TM; Curtis JM; Alexander WS; Handman E. 2003. Persistence of lesions in suppressor of cytokine signaling-1-deficient mice infected with Leishmania major. J Immunol 170(8):4267-72. [PubMed: 12682261]  [MGI Ref ID J:125437]

Bullen DV; Darwiche R; Metcalf D; Handman E; Alexander WS. 2001. Neutralization of interferon-gamma in neonatal SOCS1-/- mice prevents fatty degeneration of the liver but not subsequent fatal inflammatory disease. Immunology 104(1):92-8. [PubMed: 11576226]  [MGI Ref ID J:71691]

Buono C; Come CE; Stavrakis G; Maguire GF; Connelly PW; Lichtman AH. 2003. Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouse. Arterioscler Thromb Vasc Biol 23(3):454-60. [PubMed: 12615659]  [MGI Ref ID J:103072]

Burne MJ; Daniels F; El Ghandour A; Mauiyyedi S; Colvin RB; O'Donnell MP; Rabb H. 2001. Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure. J Clin Invest 108(9):1283-90. [PubMed: 11696572]  [MGI Ref ID J:118005]

Burrell BE; Csencsits K; Lu G; Grabauskiene S; Bishop DK. 2008. CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice. J Immunol 181(6):3906-14. [PubMed: 18768845]  [MGI Ref ID J:139106]

Buxbaum LU; Uzonna JE; Goldschmidt MH; Scott P. 2002. Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent. Eur J Immunol 32(11):3206-15. [PubMed: 12555666]  [MGI Ref ID J:115538]

Caccamo N; Sireci G; Meraviglia S; Dieli F; Ivanyi J; Salerno A. 2006. gammadelta T cells condition dendritic cells in vivo for priming pulmonary CD8 T cell responses against Mycobacterium tuberculosis. Eur J Immunol 36(10):2681-90. [PubMed: 16981183]  [MGI Ref ID J:118094]

Cafruny WA; Bradley SE; Rowland RR. 1999. Regulation of immune complexes during infection of mice with lactate dehydrogenase-elevating virus: studies with interferon-gamma gene knockout and tolerant mice. Viral Immunol 12(2):163-73. [PubMed: 10413362]  [MGI Ref ID J:58076]

Cain JA; Smith JA; Ondr JK; Wang B; Katz JD. 2006. NKT cells and IFN-gamma establish the regulatory environment for the control of diabetogenic T cells in the nonobese diabetic mouse. J Immunol 176(3):1645-54. [PubMed: 16424194]  [MGI Ref ID J:126603]

Campos MA; Closel M; Valente EP; Cardoso JE; Akira S; Alvarez-Leite JI; Ropert C; Gazzinelli RT. 2004. Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88. J Immunol 172(3):1711-8. [PubMed: 14734753]  [MGI Ref ID J:87693]

Campos RA; Szczepanik M; Itakura A; Akahira-Azuma M; Sidobre S; Kronenberg M; Askenase PW. 2003. Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity. J Exp Med 198(12):1785-96. [PubMed: 14676294]  [MGI Ref ID J:132827]

Cannons JL; Yu LJ; Hill B; Mijares LA; Dombroski D; Nichols KE; Antonellis A; Koretzky GA; Gardner K; Schwartzberg PL. 2004. SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1. Immunity 21(5):693-706. [PubMed: 15539155]  [MGI Ref ID J:93887]

Carvalho-Pinto CE; Garcia MI; Mellado M; Rodriguez-Frade JM; Martin-Caballero J; Flores J; Martinez-A C; Balomenos D. 2002. Autocrine production of IFN-gamma by macrophages controls their recruitment to kidney and the development of glomerulonephritis in MRL/lpr mice. J Immunol 169(2):1058-67. [PubMed: 12097414]  [MGI Ref ID J:123834]

Castilow EM; Legge KL; Varga SM. 2008. Cutting edge: Eosinophils do not contribute to respiratory syncytial virus vaccine-enhanced disease. J Immunol 181(10):6692-6. [PubMed: 18981084]  [MGI Ref ID J:140954]

Cenci E; Mencacci A; Del Sero G; Bacci A; Montagnoli C; d'Ostiani CF; Mosci P; Bachmann M; Bistoni F; Kopf M; Romani L. 1999. Interleukin-4 causes susceptibility to invasive pulmonary aspergillosis through suppression of protective type I responses. J Infect Dis 180(6):1957-68. [PubMed: 10558953]  [MGI Ref ID J:119841]

Cernetich A; Garver LS; Jedlicka AE; Klein PW; Kumar N; Scott AL; Klein SL. 2006. Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection. Infect Immun 74(6):3190-203. [PubMed: 16714546]  [MGI Ref ID J:109239]

Chan WC; Duong TT; Yeung RS. 2004. Presence of IFN-gamma does not indicate its necessity for induction of coronary arteritis in an animal model of Kawasaki disease. J Immunol 173(5):3492-503. [PubMed: 15322214]  [MGI Ref ID J:92708]

Chang JT; Shevach EM; Segal BM. 1999. Regulation of interleukin (IL)-12 receptor beta2 subunit expression by endogenous IL-12: a critical step in the differentiation of pathogenic autoreactive T cells. J Exp Med 189(6):969-78. [PubMed: 10075980]  [MGI Ref ID J:53619]

Chen ES; Greenlee BM; Wills-Karp M; Moller DR. 2001. Attenuation of lung inflammation and fibrosis in interferon-gamma-deficient mice after intratracheal bleomycin. Am J Respir Cell Mol Biol 24(5):545-55. [PubMed: 11350823]  [MGI Ref ID J:114439]

Chen K; Wei Y; Sharp GC; Braley-Mullen H. 2003. Mechanisms of spontaneous resolution versus fibrosis in granulomatous experimental autoimmune thyroiditis. J Immunol 171(11):6236-43. [PubMed: 14634140]  [MGI Ref ID J:117995]

Chen Y; Chong MM; Darwiche R; Thomas HE; Kay TW. 2004. Severe pancreatitis with exocrine destruction and increased islet neogenesis in mice with suppressor of cytokine signaling-1 deficiency. Am J Pathol 165(3):913-21. [PubMed: 15331415]  [MGI Ref ID J:92419]

Cheng M; Nguyen MH; Fantuzzi G; Koh TJ. 2008. Endogenous interferon-gamma is required for efficient skeletal muscle regeneration. Am J Physiol Cell Physiol 294(5):C1183-91. [PubMed: 18353892]  [MGI Ref ID J:136628]

Chensue SW; Warmington K; Ruth JH; Lukacs N; Kunkel SL. 1997. Mycobacterial and schistosomal antigen-elicited granuloma formation in IFN-gamma and IL-4 knockout mice: analysis of local and regional cytokine and chemokine networks. J Immunol 159(7):3565-73. [PubMed: 9317156]  [MGI Ref ID J:43085]

Chiaramonte MG; Hesse M; Cheever AW; Wynn TA. 2000. CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism. J Immunol 164(2):973-85. [PubMed: 10623847]  [MGI Ref ID J:127058]

Chiarle R; Martinengo C; Mastini C; Ambrogio C; D'Escamard V; Forni G; Inghirami G. 2008. The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination. Nat Med 14(6):676-80. [PubMed: 18469826]  [MGI Ref ID J:136968]

Chinen T; Kobayashi T; Ogata H; Takaesu G; Takaki H; Hashimoto M; Yagita H; Nawata H; Yoshimura A. 2006. Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved. Gastroenterology 130(2):373-88. [PubMed: 16472593]  [MGI Ref ID J:124924]

Chiodoni C; Stoppacciaro A; Sangaletti S; Gri G; Cappetti B; Koezuka Y; Colombo MP. 2001. Different requirements for alpha-galactosylceramide and recombinant IL-12 antitumor activity in the treatment of C-26 colon carcinoma hepatic metastases. Eur J Immunol 31(10):3101-10. [PubMed: 11592087]  [MGI Ref ID J:115631]

Choi KS; Song EK; Yim CY. 2008. Cytokines secreted by IL-2-activated lymphocytes induce endogenous nitric oxide synthesis and apoptosis in macrophages. J Leukoc Biol 83(6):1440-50. [PubMed: 18339892]  [MGI Ref ID J:136847]

Christensen JE; Wodarz D; Christensen JP; Thomsen AR. 2004. Perforin and IFN-gamma do not significantly regulate the virus-specific CD8+ T cell response in the absence of antiviral effector activity. Eur J Immunol 34(5):1389-94. [PubMed: 15114672]  [MGI Ref ID J:89390]

Christensen JP; Bartholdy C; Wodarz D; Thomsen AR. 2001. Depletion of CD4+ T cells precipitates immunopathology in immunodeficient mice infected with a noncytocidal virus. J Immunol 166(5):3384-91. [PubMed: 11207295]  [MGI Ref ID J:126477]

Chu CQ; Song Z; Mayton L; Wu B; Wooley PH. 2003. IFNgamma deficient C57BL/6 (H-2b) mice develop collagen induced arthritis with predominant usage of T cell receptor Vbeta6 and Vbeta8 in arthritic joints. Ann Rheum Dis 62(10):983-90. [PubMed: 12972478]  [MGI Ref ID J:106216]

Chu CQ; Wittmer S; Dalton DK. 2000. Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis J Exp Med 192(1):123-8. [PubMed: 10880533]  [MGI Ref ID J:63143]

Cohn L; Herrick C; Niu N; Homer R; Bottomly K. 2001. IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation. J Immunol 166(4):2760-7. [PubMed: 11160342]  [MGI Ref ID J:126916]

Collins JT; Shi J; Burrell BE; Bishop DK; Dunnick WA. 2006. Induced expression of murine gamma2a by CD40 ligation independently of IFN-gamma. J Immunol 177(8):5414-9. [PubMed: 17015727]  [MGI Ref ID J:139436]

Combe CL; Moretto MM; Schwartzman JD; Gigley JP; Bzik DJ; Khan IA. 2006. Lack of IL-15 results in the suboptimal priming of CD4+ T cell response against an intracellular parasite. Proc Natl Acad Sci U S A 103(17):6635-40. [PubMed: 16614074]  [MGI Ref ID J:109105]

Cone RE; Li X; Sharafieh R; O'Rourke J; Vella AT. 2007. The suppression of delayed-type hypersensitivity by CD8+ regulatory T cells requires interferon-gamma. Immunology 120(1):112-9. [PubMed: 17052246]  [MGI Ref ID J:122316]

Cooper AM; Dalton DK; Stewart TA; Griffin JP; Russell DG; Orme IM. 1993. Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med 178(6):2243-7. [PubMed: 8245795]  [MGI Ref ID J:15723]

Cornish AL; Chong MM; Davey GM; Darwiche R; Nicola NA; Hilton DJ; Kay TW; Starr R; Alexander WS. 2003. Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells. J Biol Chem 278(25):22755-61. [PubMed: 12665516]  [MGI Ref ID J:124411]

Cornish AL; Davey GM; Metcalf D; Purton JF; Corbin JE; Greenhalgh CJ; Darwiche R; Wu L; Nicola NA; Godfrey DI; Heath WR; Hilton DJ; Alexander WS; Starr R. 2003. Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis. J Immunol 170(2):878-86. [PubMed: 12517953]  [MGI Ref ID J:127134]

Croker B; Crozat K; Berger M; Xia Y; Sovath S; Schaffer L; Eleftherianos I; Imler JL; Beutler B. 2007. ATP-sensitive potassium channels mediate survival during infection in mammals and insects. Nat Genet 39(12):1453-60. [PubMed: 18026101]  [MGI Ref ID J:126658]

Croom HA; Izon DJ; Chong MM; Curtis DJ; Roberts AW; Kay TW; Hilton DJ; Alexander WS; Starr R. 2008. Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3. Mol Immunol 45(10):2888-96. [PubMed: 18321577]  [MGI Ref ID J:134472]

Cruz A; Khader SA; Torrado E; Fraga A; Pearl JE; Pedrosa J; Cooper AM; Castro AG. 2006. Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection. J Immunol 177(3):1416-20. [PubMed: 16849446]  [MGI Ref ID J:137981]

Dai JH; Iwatani Y; Ishida T; Terunuma H; Kasai H; Iwakula Y; Fujiwara H; Ito M. 2001. Glycyrrhizin enhances interleukin-12 production in peritoneal macrophages. Immunology 103(2):235-43. [PubMed: 11412311]  [MGI Ref ID J:69773]

Dalton DK; Haynes L; Chu CQ; Swain SL; Wittmer S. 2000. Interferon gamma eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells. J Exp Med 192(1):117-22. [PubMed: 10880532]  [MGI Ref ID J:115328]

Dandekar AA; Anghelina D; Perlman S. 2004. Bystander CD8 T-cell-mediated demyelination is interferon-gamma-dependent in a coronavirus model of multiple sclerosis. Am J Pathol 164(2):363-9. [PubMed: 14742242]  [MGI Ref ID J:88552]

Davey GM; Starr R; Cornish AL; Burghardt JT; Alexander WS; Carbone FR; Surh CD; Heath WR. 2005. SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential. J Exp Med 202(8):1099-108. [PubMed: 16216888]  [MGI Ref ID J:116818]

De Paiva CS; Villarreal AL; Corrales RM; Rahman HT; Chang VY; Farley WJ; Stern ME; Niederkorn JY; Li DQ; Pflugfelder SC. 2007. Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. Invest Ophthalmol Vis Sci 48(6):2553-60. [PubMed: 17525184]  [MGI Ref ID J:123281]

Deepe GS Jr; Gibbons RS. 2008. TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis. J Immunol 180(2):1088-97. [PubMed: 18178849]  [MGI Ref ID J:130944]

Ding Q; Lu L; Wang B; Zhou Y; Jiang Y; Zhou X; Xin L; Jiao Z; Chou KY. 2006. B7H1-Ig fusion protein activates the CD4+ IFN-gamma receptor+ type 1 T regulatory subset through IFN-gamma-secreting Th1 cells. J Immunol 177(6):3606-14. [PubMed: 16951320]  [MGI Ref ID J:138053]

Dogan RN; Vasu C; Holterman MJ; Prabhakar BS. 2003. Absence of IL-4, and not suppression of the Th2 response, prevents development of experimental autoimmune Graves' disease. J Immunol 170(4):2195-204. [PubMed: 12574393]  [MGI Ref ID J:126279]

Doherty TM; Sher A. 1997. Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection. J Immunol 158(10):4822-31. [PubMed: 9144497]  [MGI Ref ID J:40202]

Dohi T; Fujihashi K; Kiyono H; Elson CO; McGhee JR. 2000. Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis. Gastroenterology 119(3):724-33. [PubMed: 10982767]  [MGI Ref ID J:64230]

Dohi T; Fujihashi K; Koga T; Etani Y; Yoshino N; Kawamura YI; McGhee JR. 2004. CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis. Am J Pathol 165(4):1257-68. [PubMed: 15466391]  [MGI Ref ID J:93676]

Dohi T; Fujihashi K; Koga T; Shirai Y; Kawamura YI; Ejima C; Kato R; Saitoh K; McGhee JR. 2003. T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell-deficient mice. Gastroenterology 124(3):672-82. [PubMed: 12612906]  [MGI Ref ID J:82106]

Dohi T; Fujihashi K; Rennert PD; Iwatani K; Kiyono H; McGhee JR. 1999. Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses. J Exp Med 189(8):1169-80. [PubMed: 10209035]  [MGI Ref ID J:119172]

Dokun AO; Chu DT; Yang L; Bendelac AS; Yokoyama WM. 2001. Analysis of in situ NK cell responses during viral infection. J Immunol 167(9):5286-93. [PubMed: 11673544]  [MGI Ref ID J:72673]

Doodes PD; Cao Y; Hamel KM; Wang Y; Farkas B; Iwakura Y; Finnegan A. 2008. Development of proteoglycan-induced arthritis is independent of IL-17. J Immunol 181(1):329-37. [PubMed: 18566398]  [MGI Ref ID J:137406]

Doolan DL; Hoffman SL. 1999. IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii model. J Immunol 163(2):884-92. [PubMed: 10395683]  [MGI Ref ID J:119784]

Drevets DA; Schawang JE; Dillon MJ; Lerner MR; Bronze MS; Brackett DJ. 2008. Innate responses to systemic infection by intracellular bacteria trigger recruitment of Ly-6Chigh monocytes to the brain. J Immunol 181(1):529-36. [PubMed: 18566419]  [MGI Ref ID J:137399]

Dubey JP; Liddell S; Mattson D; Speert CA; Howe DK; Jenkins MC. 2001. Characterization of the Oregon isolate of Neospora hughesi from a horse. J Parasitol 87(2):345-53. [PubMed: 11318565]  [MGI Ref ID J:109880]

Dunussi-Joannopoulos K; Hancock GE; Kunz A; Hegen M; Zhou XX; Sheppard BJ; Lamothe J; Li E; Ma HL; Hamann PR; Damle NK; Collins M. 2005. B-cell depletion inhibits arthritis in a collagen-induced arthritis (CIA) model, but does not adversely affect humoral responses in a respiratory syncytial virus (RSV) vaccination model. Blood 106(7):2235-43. [PubMed: 15947095]  [MGI Ref ID J:119369]

Durbin JE; Fernandez-Sesma A; Lee CK; Rao TD; Frey AB; Moran TM; Vukmanovic S; Garcia-Sastre A; Levy DE. 2000. Type I IFN modulates innate and specific antiviral immunity. J Immunol 164(8):4220-8. [PubMed: 10754318]  [MGI Ref ID J:123432]

Durbin JE; Johnson TR; Durbin RK; Mertz SE; Morotti RA; Peebles RS; Graham BS. 2002. The role of IFN in respiratory syncytial virus pathogenesis. J Immunol 168(6):2944-52. [PubMed: 11884466]  [MGI Ref ID J:126678]

Eaton KA; Mefford M; Thevenot T. 2001. The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice. J Immunol 166(12):7456-61. [PubMed: 11390498]  [MGI Ref ID J:124425]

Egan PJ; Lawlor KE; Alexander WS; Wicks IP. 2003. Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation. J Clin Invest 111(6):915-24. [PubMed: 12639998]  [MGI Ref ID J:82519]

Ellison CA; Fischer JM; HayGlass KT; Gartner JG. 1998. Murine graft-versus-host disease in an F1-hybrid model using IFN-gamma gene knockout donors. J Immunol 161(2):631-40. [PubMed: 9670937]  [MGI Ref ID J:48545]

Ely KH; Kasper LH; Khan IA. 1999. Augmentation of the CD8+ T cell response by IFN-gamma in IL-12-deficient mice during Toxoplasma gondii infection. J Immunol 162(9):5449-54. [PubMed: 10228024]  [MGI Ref ID J:111011]

Enzler T; Gillessen S; Manis JP; Ferguson D; Fleming J; Alt FW; Mihm M; Dranoff G. 2003. Deficiencies of GM-CSF and interferon gamma link inflammation and cancer. J Exp Med 197(9):1213-9. [PubMed: 12732663]  [MGI Ref ID J:83086]

Eriksson U; Kurrer MO; Sebald W; Brombacher F; Kopf M. 2001. Dual role of the IL-12/IFN-gamma axis in the development of autoimmune myocarditis: induction by IL-12 and protection by IFN-gamma. J Immunol 167(9):5464-9. [PubMed: 11673566]  [MGI Ref ID J:72665]

Evel-Kabler K; Song XT; Aldrich M; Huang XF; Chen SY. 2006. SOCS1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling. J Clin Invest 116(1):90-100. [PubMed: 16357940]  [MGI Ref ID J:105256]

Eyles JL; Metcalf D; Grusby MJ; Hilton DJ; Starr R. 2002. Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1. J Biol Chem 277(46):43735-40. [PubMed: 12221108]  [MGI Ref ID J:119132]

Fairweather D; Frisancho-Kiss S; Yusung SA; Barrett MA; Davis SE; Gatewood SJ; Njoku DB; Rose NR. 2004. Interferon-gamma protects against chronic viral myocarditis by reducing mast cell degranulation, fibrosis, and the profibrotic cytokines transforming growth factor-beta 1, interleukin-1 beta, and interleukin-4 in the heart. Am J Pathol 165(6):1883-94. [PubMed: 15579433]  [MGI Ref ID J:94973]

Fairweather D; Frisancho-Kiss S; Yusung SA; Barrett MA; Davis SE; Steele RA; Gatewood SJ; Rose NR. 2005. IL-12 protects against coxsackievirus B3-induced myocarditis by increasing IFN-gamma and macrophage and neutrophil populations in the heart. J Immunol 174(1):261-9. [PubMed: 15611248]  [MGI Ref ID J:95857]

Fairweather D; Yusung S; Frisancho S; Barrett M; Gatewood S; Steele R; Rose NR. 2003. IL-12 Receptor beta1 and Toll-Like Receptor 4 Increase IL-1beta- and IL-18-Associated Myocarditis and Coxsackievirus Replication. J Immunol 170(9):4731-7. [PubMed: 12707353]  [MGI Ref ID J:83020]

Fallarino F; Bianchi R; Orabona C; Vacca C; Belladonna ML; Fioretti MC; Serreze DV; Grohmann U; Puccetti P. 2004. CTLA-4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice. J Exp Med 200(8):1051-62. [PubMed: 15492127]  [MGI Ref ID J:93957]

Feng CG; Kaviratne M; Rothfuchs AG; Cheever A; Hieny S; Young HA; Wynn TA; Sher A. 2006. NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis. J Immunol 177(10):7086-93. [PubMed: 17082625]  [MGI Ref ID J:140483]

Feng CG; Scanga CA; Collazo-Custodio CM; Cheever AW; Hieny S; Caspar P; Sher A. 2003. Mice lacking myeloid differentiation factor 88 display profound defects in host resistance and immune responses to Mycobacterium avium infection not exhibited by Toll-like receptor 2 (TLR2)- and TLR4-deficient animals. J Immunol 171(9):4758-64. [PubMed: 14568952]  [MGI Ref ID J:118915]

Feng HM; Walker DH. 2004. Mechanisms of immunity to Ehrlichia muris: a model of monocytotropic ehrlichiosis. Infect Immun 72(2):966-71. [PubMed: 14742542]  [MGI Ref ID J:87862]

Fenner JE; Starr R; Cornish AL; Zhang JG; Metcalf D; Schreiber RD; Sheehan K; Hilton DJ; Alexander WS; Hertzog PJ. 2006. Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity. Nat Immunol 7(1):33-9. [PubMed: 16311601]  [MGI Ref ID J:112593]

Ferber IA; Brocke S; Taylor-Edwards C; Ridgway W; Dinisco C; Steinman L; Dalton D; Fathman CG. 1996. Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol 156(1):5-7. [PubMed: 8598493]  [MGI Ref ID J:30237]

Feuerer M; Eulenburg K; Loddenkemper C; Hamann A; Huehn J. 2006. Self-limitation of Th1-mediated inflammation by IFN-gamma. J Immunol 176(5):2857-63. [PubMed: 16493042]  [MGI Ref ID J:129422]

Finnegan A; Grusby MJ; Kaplan CD; O'Neill SK; Eibel H; Koreny T; Czipri M; Mikecz K; Zhang J. 2002. IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms. J Immunol 169(6):3345-52. [PubMed: 12218156]  [MGI Ref ID J:120443]

Fischer R; Tome D; McGhee JR; Boyaka PN. 2007. Th1 and Th2 cells are required for both eosinophil- and neutrophil-associated airway inflammatory responses in mice. Biochem Biophys Res Commun 357(1):44-9. [PubMed: 17412309]  [MGI Ref ID J:121793]

Flaishon L; Hershkoviz R; Lantner F; Lider O; Alon R; Levo Y; Flavell RA; Shachar I. 2000. Autocrine secretion of interferon gamma negatively regulates homing of immature B cells. J Exp Med 192(9):1381-8. [PubMed: 11067886]  [MGI Ref ID J:112084]

Flano E; Woodland DL; Blackman MA. 1999. Requirement for CD4+ T cells in V beta 4+CD8+ T cell activation associated with latent murine gammaherpesvirus infection. J Immunol 163(6):3403-8. [PubMed: 10477611]  [MGI Ref ID J:119171]

Florido M; Pearl JE; Solache A; Borges M; Haynes L; Cooper AM; Appelberg R. 2005. Gamma interferon-induced T-cell loss in virulent Mycobacterium avium infection. Infect Immun 73(6):3577-86. [PubMed: 15908387]  [MGI Ref ID J:99143]

Flynn JL; Chan J; Triebold KJ; Dalton DK; Stewart TA; Bloom BR. 1993. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med 178(6):2249-54. [PubMed: 7504064]  [MGI Ref ID J:110856]

Flynn JL; Goldstein MM; Triebold KJ; Sypek J; Wolf S; Bloom BR. 1995. IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection. J Immunol 155(5):2515-24. [PubMed: 7650381]  [MGI Ref ID J:28196]

Fogler WE; Volker K; Watanabe M; Wigginton JM; Roessler P; Brunda MJ; Ortaldo JR; Wiltrout RH. 1998. Recruitment of hepatic NK cells by IL-12 is dependent on IFN-gamma and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas. J Immunol 161(11):6014-21. [PubMed: 9834083]  [MGI Ref ID J:115033]

France MP; Smith AL; Stevenson R; Barthold SW. 1999. Granulomatous peritonitis and pleuritis in interferon-gamma gene knockout mice naturally infected with mouse hepatitis virus. Aust Vet J 77(9):600-4. [PubMed: 10561796]  [MGI Ref ID J:59661]

Freyschmidt-Paul P; McElwee KJ; Hoffmann R; Sundberg JP; Vitacolonna M; Kissling S; Zoller M. 2006. Interferon-gamma-deficient mice are resistant to the development of alopecia areata. Br J Dermatol 155(3):515-21. [PubMed: 16911275]  [MGI Ref ID J:135859]

Fritz RB; Zhao ML. 2001. Regulation of experimental autoimmune encephalomyelitis in the C57BL/6J mouse by NK1.1+, DX5+, alpha beta+ T cells. J Immunol 166(6):4209-15. [PubMed: 11238673]  [MGI Ref ID J:126134]

Fujigaki S; Saito K; Sekikawa K; Tone S; Takikawa O; Fujii H; Wada H; Noma A; Seishima M. 2001. Lipopolysaccharide induction of indoleamine 2,3-dioxygenase is mediated dominantly by an IFN-gamma-independent mechanism. Eur J Immunol 31(8):2313-8. [PubMed: 11477543]  [MGI Ref ID J:71158]

Fukushima A; Yamaguchi T; Ishida W; Fukata K; Mittler RS; Yagita H; Ueno H. 2005. Engagement of 4-1BB inhibits the development of experimental allergic conjunctivitis in mice. J Immunol 175(8):4897-903. [PubMed: 16210591]  [MGI Ref ID J:119054]

Fukushima A; Yamaguchi T; Ishida W; Fukata K; Taniguchi T; Liu FT; Ueno H. 2006. Genetic background determines susceptibility to experimental immune-mediated blepharoconjunctivitis: comparison of Balb/c and C57BL/6 mice. Exp Eye Res 82(2):210-8. [PubMed: 16102751]  [MGI Ref ID J:106441]

Gajendran N; Mittrucker HW; Bordasch K; Heinemann E; Koch M; Kaufmann SH. 2007. Regional IFN{gamma} expression is insufficient for efficacious control of food-borne bacterial pathogens at the gut epithelial barrier. Int Immunol 19(9):1075-81. [PubMed: 17698562]  [MGI Ref ID J:124869]

Gallina G; Dolcetti L; Serafini P; De Santo C; Marigo I; Colombo MP; Basso G; Brombacher F; Borrello I; Zanovello P; Bicciato S; Bronte V. 2006. Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J Clin Invest 116(10):2777-90. [PubMed: 17016559]  [MGI Ref ID J:114986]

Gao D; Kasten-Jolly J; Lawrence DA. 2006. The paradoxical effects of lead in interferon-gamma knockout BALB/c mice. Toxicol Sci 89(2):444-53. [PubMed: 16280381]  [MGI Ref ID J:113282]

Gao JJ; Filla MB; Fultz MJ; Vogel SN; Russell SW; Murphy WJ. 1998. Autocrine/paracrine IFN-alphabeta mediates the lipopolysaccharide-induced activation of transcription factor Stat1alpha in mouse macrophages: pivotal role of Stat1alpha in induction of the inducible nitric oxide synthase gene. J Immunol 161(9):4803-10. [PubMed: 9794412]  [MGI Ref ID J:115235]

Gao N; Dang T; Dunnick WA; Collins JT; Blazar BR; Yuan D. 2005. Receptors and counterreceptors involved in NK-B cell interactions. J Immunol 174(7):4113-9. [PubMed: 15778370]  [MGI Ref ID J:97960]

Gao N; Jennings P; Yuan D. 2008. Requirements for the natural killer cell-mediated induction of IgG1 and IgG2a expression in B lymphocytes. Int Immunol 20(5):645-57. [PubMed: 18339657]  [MGI Ref ID J:134466]

Gao X; Gillig TA; Ye P; D'Ercole AJ; Matsushima GK; Popko B. 2000. Interferon-gamma protects against cuprizone-induced demyelination Mol Cell Neurosci 16(4):338-49. [PubMed: 11085872]  [MGI Ref ID J:65508]

Gao Y; Grassi F; Ryan MR; Terauchi M; Page K; Yang X; Weitzmann MN; Pacifici R. 2007. IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation. J Clin Invest 117(1):122-32. [PubMed: 17173138]  [MGI Ref ID J:117462]

Gao Y; Tao J; Li MO; Zhang D; Chi H; Henegariu O; Kaech SM; Davis RJ; Flavell RA; Yin Z. 2005. JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance. J Immunol 175(9):5783-9. [PubMed: 16237070]  [MGI Ref ID J:119340]

Gingras S; Parganas E; de Pauw A; Ihle JN; Murray PJ. 2004. Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling. J Biol Chem 279(52):54702-7. [PubMed: 15491990]  [MGI Ref ID J:95152]

Glabinski AR; Krakowski M; Han Y; Owens T; Ransohoff RM. 1999. Chemokine expression in GKO mice (lacking interferon-gamma) with experimental autoimmune encephalomyelitis. J Neurovirol 5(1):95-101. [PubMed: 10190695]  [MGI Ref ID J:53694]

Goes N; Sims T; Urmson J; Vincent D; Ramassar V; Halloran PF. 1995. Disturbed MHC regulation in the IFN-gamma knockout mouse. Evidence for three states of MHC expression with distinct roles for IFN-gamma. J Immunol 155(10):4559-66. [PubMed: 7594453]  [MGI Ref ID J:29680]

Goes N; Urmson J; Hobart M; Halloran PF. 1996. The unique role of interferon-gamma in the regulation of MHC expression on arterial endothelium. Transplantation 62(12):1889-94. [PubMed: 8990382]  [MGI Ref ID J:37405]

Goes N; Urmson J; Vincent D; Halloran PF. 1995. Acute renal injury in the interferon-gamma gene knockout mouse: effect on cytokine gene expression. Transplantation 60(12):1560-4. [PubMed: 8545890]  [MGI Ref ID J:31381]

Goldman KP; Park CS; Kim M; Matzinger P; Anderson CC. 2005. Thymic cortical epithelium induces self tolerance. Eur J Immunol 35(3):709-17. [PubMed: 15719367]  [MGI Ref ID J:96619]

Goldszmid RS; Bafica A; Jankovic D; Feng CG; Caspar P; Winkler-Pickett R; Trinchieri G; Sher A. 2007. TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-{gamma} production. J Exp Med 204(11):2591-602. [PubMed: 17923502]  [MGI Ref ID J:126112]

Gomes MS; Sousa Fernandes S; Cordeiro JV; Silva Gomes S; Vieira A; Appelberg R. 2008. Engagement of Toll-like receptor 2 in mouse macrophages infected with Mycobacterium avium induces non-oxidative and TNF-independent anti-mycobacterial activity. Eur J Immunol 38(8):2180-9. [PubMed: 18624355]  [MGI Ref ID J:138559]

Gorham JD; Lin JT; Sung JL; Rudner LA; French MA. 2001. Genetic regulation of autoimmune disease: balb/c background tgf-beta1-deficient mice develop necroinflammatory ifn-gamma-dependent hepatitis. J Immunol 166(10):6413-22. [PubMed: 11342667]  [MGI Ref ID J:69346]

Gourzi P; Leonova T; Papavasiliou FN. 2007. Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB. J Exp Med 204(2):259-65. [PubMed: 17242162]  [MGI Ref ID J:125375]

Graham MB; Dalton DK; Giltinan D; Braciale VL; Stewart TA; Braciale TJ. 1993. Response to influenza infection in mice with a targeted disruption in the interferon gamma gene. J Exp Med 178(5):1725-32. [PubMed: 8228818]  [MGI Ref ID J:110721]

Gramaglia I; Sahlin H; Nolan JP; Frangos JA; Intaglietta M; van der Heyde HC. 2005. Cell- rather than antibody-mediated immunity leads to the development of profound thrombocytopenia during experimental Plasmodium berghei malaria. J Immunol 175(11):7699-707. [PubMed: 16301680]  [MGI Ref ID J:122163]

Gupta M; Greer P; Mahanty S; Shieh WJ; Zaki SR; Ahmed R; Rollin PE. 2005. CD8-mediated protection against Ebola virus infection is perforin dependent. J Immunol 174(7):4198-202. [PubMed: 15778381]  [MGI Ref ID J:97965]

Halloran PF; Afrouzian M; Ramassar V; Urmson J; Zhu LF; Helms LM; Solez K; Kneteman NM. 2001. Interferon-gamma acts directly on rejecting renal allografts to prevent graft necrosis. Am J Pathol 158(1):215-26. [PubMed: 11141495]  [MGI Ref ID J:68439]

Halloran PF; Miller LW; Urmson J; Ramassar V; Zhu LF; Kneteman NM; Solez K; Afrouzian M. 2001. IFN-gamma alters the pathology of graft rejection: protection from early necrosis. J Immunol 166(12):7072-81. [PubMed: 11390451]  [MGI Ref ID J:123807]

Hamadien M; Lycke N; Bakhiet M. 1999. Induction of the trypanosome lymphocyte-triggering factor (TLTF) and neutralizing antibodies to the TLTF in experimental african trypanosomiasis. Immunology 96(4):606-11. [PubMed: 10233748]  [MGI Ref ID J:110523]

Hanada T; Kobayashi T; Chinen T; Saeki K; Takaki H; Koga K; Minoda Y; Sanada T; Yoshioka T; Mimata H; Kato S; Yoshimura A. 2006. IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. J Exp Med 203(6):1391-7. [PubMed: 16717119]  [MGI Ref ID J:115075]

Hancock WW; Szaba FM; Berggren KN; Parent MA; Mullarky IK; Pearl J; Cooper AM; Ely KH; Woodland DL; Kim IJ; Blackman MA; Johnson LL; Smiley ST. 2004. Intact type 1 immunity and immune-associated coagulative responses in mice lacking IFN gamma-inducible fibrinogen-like protein 2. Proc Natl Acad Sci U S A 101(9):3005-10. [PubMed: 14976252]  [MGI Ref ID J:88648]

Hao S; Yuan J; Xu S; Munegowda MA; Deng Y; Gordon J; Xing Z; Xiang J. 2008. Antigen specificity acquisition of adoptive CD4+ regulatory T cells via acquired peptide-MHC class I complexes. J Immunol 181(4):2428-37. [PubMed: 18684933]  [MGI Ref ID J:140189]

Haring JS; Badovinac VP; Olson MR; Varga SM; Harty JT. 2005. In vivo generation of pathogen-specific Th1 cells in the absence of the IFN-gamma receptor. J Immunol 175(5):3117-22. [PubMed: 16116201]  [MGI Ref ID J:113254]

Haring JS; Harty JT. 2006. Aberrant contraction of antigen-specific CD4 T cells after infection in the absence of gamma interferon or its receptor. Infect Immun 74(11):6252-63. [PubMed: 16966404]  [MGI Ref ID J:113551]

Harrington LE; Hatton RD; Mangan PR; Turner H; Murphy TL; Murphy KM; Weaver CT. 2005. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6(11):1123-32. [PubMed: 16200070]  [MGI Ref ID J:112601]

Harris DP; Goodrich S; Gerth AJ; Peng SL; Lund FE. 2005. Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor. J Immunol 174(11):6781-90. [PubMed: 15905519]  [MGI Ref ID J:99038]

Harris TH; Mansfield JM; Paulnock DM. 2007. CpG oligodeoxynucleotide treatment enhances innate resistance and acquired immunity to African trypanosomes. Infect Immun 75(5):2366-73. [PubMed: 17339353]  [MGI Ref ID J:121887]

Hart G; Avin-Wittenberg T; Shachar I. 2008. IL-15 regulates immature B-cell homing in an Ly49D-, IL-12 , and IL-18 dependent manner. Blood 111(1):50-9. [PubMed: 17901247]  [MGI Ref ID J:130042]

Hart G; Flaishon L; Becker-Herman S; Shachar I. 2003. Ly49D receptor expressed on immature B cells regulates their IFN-gamma secretion, actin polymerization, and homing. J Immunol 171(9):4630-8. [PubMed: 14568937]  [MGI Ref ID J:119214]

Hart G; Flaishon L; Shachar I. 2007. IL-12 and IL-18 down-regulate B cell migration in an Ly49D-dependent manner. Eur J Immunol 37(7):1996-2007. [PubMed: 17557376]  [MGI Ref ID J:123474]

Harty JT; Bevan MJ. 1995. Specific immunity to Listeria monocytogenes in the absence of IFN gamma. Immunity 3(1):109-17. [PubMed: 7621071]  [MGI Ref ID J:83180]

Hata H; Sakaguchi N; Yoshitomi H; Iwakura Y; Sekikawa K; Azuma Y; Kanai C; Moriizumi E; Nomura T; Nakamura T; Sakaguchi S. 2004. Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. J Clin Invest 114(4):582-8. [PubMed: 15314695]  [MGI Ref ID J:92002]

Hausmann J; Pagenstecher A; Baur K; Richter K; Rziha HJ; Staeheli P. 2005. CD8 T cells require gamma interferon to clear borna disease virus from the brain and prevent immune system-mediated neuronal damage. J Virol 79(21):13509-18. [PubMed: 16227271]  [MGI Ref ID J:102183]

Havarinasab S; Haggqvist B; Bjorn E; Pollard KM; Hultman P. 2005. Immunosuppressive and autoimmune effects of thimerosal in mice. Toxicol Appl Pharmacol 204(2):109-21. [PubMed: 15808517]  [MGI Ref ID J:97345]

Hayward AR; Chmura K; Cosyns M. 2000. Interferon-gamma is required for innate immunity to Cryptosporidium parvum in mice. J Infect Dis 182(3):1001-4. [PubMed: 10950807]  [MGI Ref ID J:125986]

Heath L; Chrisp C; Huffnagle G; LeGendre M; Osawa Y; Hurley M; Engleberg C; Fantone J; Brieland J. 1996. Effector mechanisms responsible for gamma interferon-mediated host resistance to Legionella pneumophila lung infection: the role of endogenous nitric oxide differs in susceptible and resistant murine hosts. Infect Immun 64(12):5151-60. [PubMed: 8945559]  [MGI Ref ID J:36862]

Helmby H; Grencis RK. 2002. IL-18 regulates intestinal mastocytosis and Th2 cytokine production independently of IFN-gamma during Trichinella spiralis infection. J Immunol 169(5):2553-60. [PubMed: 12193725]  [MGI Ref ID J:120688]

Henke PK; Pearce CG; Moaveni DM; Moore AJ; Lynch EM; Longo C; Varma M; Dewyer NA; Deatrick KB; Upchurch GR Jr; Wakefield TW; Hogaboam C; Kunkel SL. 2006. Targeted deletion of CCR2 impairs deep vein thombosis resolution in a mouse model. J Immunol 177(5):3388-97. [PubMed: 16920980]  [MGI Ref ID J:139537]

Hertz CJ; Filutowicz H; Mansfield JM. 1998. Resistance to the African trypanosomes is IFN-gamma dependent. J Immunol 161(12):6775-83. [PubMed: 9862708]  [MGI Ref ID J:115095]

Hertz CJ; Mansfield JM. 1999. IFN-gamma-dependent nitric oxide production is not linked to resistance in experimental African trypanosomiasis. Cell Immunol 192(1):24-32. [PubMed: 10066343]  [MGI Ref ID J:114251]

Hofer M; Hausmann J; Staeheli P; Pagenstecher A. 2004. Cerebral expression of interleukin-12 induces neurological disease via differential pathways and recruits antigen-specific T cells in virus-infected mice. Am J Pathol 165(3):949-58. [PubMed: 15331418]  [MGI Ref ID J:92418]

Hofstetter HH; Sewell DL; Liu F; Sandor M; Forsthuber T; Lehmann PV; Fabry Z. 2003. Autoreactive T cells promote post-traumatic healing in the central nervous system. J Neuroimmunol 134(1-2):25-34. [PubMed: 12507769]  [MGI Ref ID J:119263]

Hofstra CL; Van Ark I; Hofman G; Nijkamp FP; Jardieu PM; Van Oosterhout AJ. 1998. Differential effects of endogenous and exogenous interferon-gamma on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma. Am J Respir Cell Mol Biol 19(5):826-35. [PubMed: 9806748]  [MGI Ref ID J:114213]

Hollenbaugh JA; Reome J; Dobrzanski M; Dutton RW. 2004. The rate of the CD8-dependent initial reduction in tumor volume is not limited by contact-dependent perforin, Fas ligand, or TNF-mediated cytolysis. J Immunol 173(3):1738-43. [PubMed: 15265903]  [MGI Ref ID J:92134]

Hong F; Jaruga B; Kim WH; Radaeva S; El-Assal ON; Tian Z; Nguyen VA; Gao B. 2002. Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS. J Clin Invest 110(10):1503-13. [PubMed: 12438448]  [MGI Ref ID J:80183]

Horino J; Fujimoto M; Terabe F; Serada S; Takahashi T; Soma Y; Tanaka K; Chinen T; Yoshimura A; Nomura S; Kawase I; Hayashi N; Kishimoto T; Naka T. 2008. Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice. Int Immunol 20(6):753-62. [PubMed: 18381351]  [MGI Ref ID J:136172]

Horwitz MS; Krahl T; Fine C; Lee J; Sarvetnick N. 1999. Protection from lethal coxsackievirus-induced pancreatitis by expression of gamma interferon. J Virol 73(3):1756-66. [PubMed: 9971752]  [MGI Ref ID J:120473]

Hoshino T; Winkler-Pickett RT; Mason AT; Ortaldo JR; Young HA. 1999. IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-gamma. J Immunol 162(1):51-9. [PubMed: 9886369]  [MGI Ref ID J:112424]

Houpt ER; Glembocki DJ; Obrig TG; Moskaluk CA; Lockhart LA; Wright RL; Seaner RM; Keepers TR; Wilkins TD; Petri WA Jr. 2002. The mouse model of amebic colitis reveals mouse strain susceptibility to infection and exacerbation of disease by CD4+ T cells. J Immunol 169(8):4496-503. [PubMed: 12370386]  [MGI Ref ID J:120012]

Houri-Haddad Y; Soskolne WA; Shai E; Palmon A; Shapira L. 2002. Interferon-gamma deficiency attenuates local P. gingivalis-induced inflammation. J Dent Res 81(6):395-8. [PubMed: 12097431]  [MGI Ref ID J:105950]

Hu J; Sahu N; Walsh E; August A. 2007. Memory phenotype CD8(+) T cells with innate function selectively develop in the absence of active Itk. Eur J Immunol 37(10):2892-9. [PubMed: 17724684]  [MGI Ref ID J:125268]

Huang X; McClellan SA; Barrett RP; Hazlett LD. 2002. IL-18 contributes to host resistance against infection with Pseudomonas aeruginosa through induction of IFN-gamma production. J Immunol 168(11):5756-63. [PubMed: 12023376]  [MGI Ref ID J:123799]

Hultgren B; Huang X; Dybdal N; Stewart TA. 1996. Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice. Diabetes 45(6):812-7. [PubMed: 8635658]  [MGI Ref ID J:33427]

Hung K; Hayashi R; Lafond-Walker A; Lowenstein C; Pardoll D; Levitsky H. 1998. The central role of CD4(+) T cells in the antitumor immune response. J Exp Med 188(12):2357-68. [PubMed: 9858522]  [MGI Ref ID J:51677]

Hwang SJ; Kim S; Park WS; Chung DH. 2006. IL-4-secreting NKT cells prevent hypersensitivity pneumonitis by suppressing IFN-gamma-producing neutrophils. J Immunol 177(8):5258-68. [PubMed: 17015711]  [MGI Ref ID J:139446]

Iijima H; Neurath MF; Nagaishi T; Glickman JN; Nieuwenhuis EE; Nakajima A; Chen D; Fuss IJ; Utku N; Lewicki DN; Becker C; Gallagher TM; Holmes KV; Blumberg RS. 2004. Specific regulation of T helper cell 1-mediated murine colitis by CEACAM1. J Exp Med 199(4):471-82. [PubMed: 14970176]  [MGI Ref ID J:90476