Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote         (Female x Male)   01-MAR-06 Species laboratory mouse Background Strain C57BL/6 Donor Strain 129S7 via AB1 ES cell line (+Hprt-bm2) Generation N8+2F8 (20-DEC-06)   Donating Investigator Timothy Stewart,   no forwarding info

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Related Genotype: a/a

Description
Mice homozygous for the Ifng^tm1Ts targeted mutation are viable and fertile. Homozygotes appear normal in a "clean" environment but display reduced macrophage function in response to pathogens. Specifically, macrophages show impaired production of antimicrobial products and reduced expression of MHC II antigens. There is also uncontrollable proliferation of splenocytes from homozygotes in response to mitogens and alloantigens and a reduced resting natural killer cell activity.

Control Information

	Control
	000664 C57BL/6J
Considerations for Choosing Controls

Related Strains

Strains carrying   Ifng^tm1Ts allele

002286	C.129S7(B6)-Ifngtm1Ts/J
008228	C3.129S7(B6)-Ifngtm1Ts/J
002575	NOD.129S7(B6)-Ifngtm1Ts/DvsJ

View Strains carrying   Ifng^tm1Ts     (3 strains)

Additional Web Information

Genetic Quality Control Annual Report

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

Ifng^tm1Ts/Ifng^tm1Ts

        B6.129S7-Ifng^tm1Ts/J

• immune system phenotype
• *normal* immune system phenotype (MGI Ref ID J:114783)
  • do not exhibit defects on either IgE isotype switch or IgE production
  • no abnormal response to infection is detected
• decreased interferon-gamma secretion (MGI Ref ID J:120556)
  • splenocytes fail to produce IFN-gamma in response to H. pylori antigen stimulation
• decreased interleukin-10 secretion (MGI Ref ID J:120556)
  • splenocytes from Helicobacter pylori infected mice produce 4-fold less IL-10 when cultured in the presence of H. pylori antigen
• increased NK T cell number (MGI Ref ID J:122801)
  • unlike in wild-type mice, treatment with LPS and DGalN fails to decrease NK T cell numbers
• increased interleukin-4 secretion (MGI Ref ID J:120556)
  • splenocytes from Helicobacter pylori infected mice produce significantly more IL-4 than splenocytes from wild-type controls when cultured in the presence of H. pylori antigen
• stomach inflammation (MGI Ref ID J:120556)
  • 5 weeks after Helicobacter pylori infection, mice have a significantly decreased gastritis inflammation score compared to infected wild-type mice
• cellular phenotype
• abnormal redox activity (MGI Ref ID J:122801)
  • unlike in wild-type mice, treatment with LPS and DGalN or TNF-alpha and interferon-gamma fails to increase the production of reactive oxygen species in hepatocytes
• hematopoietic system phenotype
• increased NK T cell number (MGI Ref ID J:122801)
  • unlike in wild-type mice, treatment with LPS and DGalN fails to decrease NK T cell numbers
• homeostasis/metabolism phenotype
• abnormal nitric oxide homeostasis (MGI Ref ID J:122801)
  • unlike in wild-type mice, treatment with LPS and DGalN fails to increase nitric oxide levels
• digestive/alimentary phenotype
• stomach inflammation (MGI Ref ID J:120556)
  • 5 weeks after Helicobacter pylori infection, mice have a significantly decreased gastritis inflammation score compared to infected wild-type mice

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

Ifng^tm1Ts/Ifng^tm1Ts

        involves: 129S7/SvEvBrd * C57BL/6

• immune system phenotype
• abnormal NK cell physiology (MGI Ref ID J:66802)
  • significantly lower resting splenic NK cell activity
• abnormal macrophage physiology (MGI Ref ID J:66802)
  • macrophages from BCG infected mice fail to produce nitric oxide in response to LPS challenge
  • macrophages from BCG infected mice exhibit reduced production of superoxide anion in response to PMA challenge
• abnormal MHC II cell surface expression on macrophages (MGI Ref ID J:66802)
  • macrophages from BCG infected mice exhibit reduced class II expression
• increased splenocyte proliferation (MGI Ref ID J:66802)
  • splenocytes from BCG infected mice exhibit increased proliferation in response to Con A
• increased susceptibility to bacterial infection (MGI Ref ID J:66802)
  • increased mortality following a sublethal dose of Mycobacterium bovis (BCG )
• tumorigenesis
• increased metastatic potential (MGI Ref ID J:152785)
  • following treatment with alphaGalCer, mice fail to exhibit a reduction in the number of B16F10 tumors metastasizing to the lungs unlike similarly treated wild-type mice
• increased resistance to tumor development (MGI Ref ID J:138466)
  • tumor-bearing mice treated with Th-17-polarized cells from Tg(Tcra,Tcrb)9Rest cells show increased tumor rejection compared to controls
• hematopoietic system phenotype
• increased splenocyte proliferation (MGI Ref ID J:66802)
  • splenocytes from BCG infected mice exhibit increased proliferation in response to Con A

Ifng^tm1Ts/Ifng^tm1Ts

        involves: 129S7/SvEvBrd

• immune system phenotype
• abnormal cytokine level (MGI Ref ID J:112600)
  • T cells from mice immunized with myelin oligodendrocyte glycoprotein (MOG) peptide show more IL-17a expressing cells and greater IL-17a production after MOG restimulation than controls; IL-4 is not detectable in these cells
• impaired NK cell cytolysis (MGI Ref ID J:73948)
  • activated splenic and liver NK cells are less efficient in their killing of 4T1 or Renca tumor target cells
• increased interleukin-17 secretion (MGI Ref ID J:132905)
  • following culturing of IL-17 producing T cells in vitro, IL-17 production is twice as high as in similarly treated wild-type cells
• vision/eye phenotype
• corneal vascularization (MGI Ref ID J:114973)
  • corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice
• homeostasis/metabolism phenotype
• abnormal cytokine level (MGI Ref ID J:112600)
  • T cells from mice immunized with myelin oligodendrocyte glycoprotein (MOG) peptide show more IL-17a expressing cells and greater IL-17a production after MOG restimulation than controls; IL-4 is not detectable in these cells
• cardiovascular system phenotype
• corneal vascularization (MGI Ref ID J:114973)
  • corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Ifng^tm1Ts related

Cancer Research
Growth Factors/Receptors/Cytokines

Hematological Research
Immunological Defects

Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines
Immunodeficiency
      multiple immune defects
Inflammation

Genes & Alleles

Gene & Allele Information

Allele Symbol		Ifngtm1Ts
Allele Name		targeted mutation 1, Timothy Stewart
Allele Type		Targeted (knock-out)
Common Name(s)		GKO; IFN-g KO; IFN-gamma KO; IFN-gamma-; IFN-gammatm1Ts; IFN-gammaKO; IFNgamma KO; IFNgamma-; Ifn-gtm1Ts; Ifntm/Ts; Ifngtm1Ts; Ifngtm1Ts; ifgtm1; ifntm1Ts; ifng-;
Mutation Made By		Timothy Stewart,   no forwarding info
Strain of Origin		129S7/SvEvBrd-Hprt1<+>
ES Cell Line Name		AB1
ES Cell Line Strain		129S7/SvEvBrd-Hprt1<+>
Gene Symbol and Name		Ifng, interferon gamma
Chromosome		10
Gene Common Name(s)		IFG; IFI; IFN-gamma; IFNG2; Ifg;
Molecular Note		Insertion of a neomycin gene into exon 2, which introduced a termination codon after the first 30 amino acids of the mature protein. [MGI Ref ID J:66802]

Genotyping

Genotyping Information

Genotyping Protocols

Ifng^tm1Ts, Standard PCR

Helpful Links

Genotyping resources and troubleshooting

References

References

Selected Reference(s)

Dalton DK; Pitts-Meek S; Keshav S; Figari IS; Bradley A; Stewart TA. 1993. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes [see comments] Science 259(5102):1739-42. [PubMed: 8456300]  [MGI Ref ID J:66802]

Additional References

Alcaide P; Fresno M. 2004. The Trypanosoma cruzi membrane mucin AgC10 inhibits T cell activation and IL-2 transcription through L-selectin. Int Immunol 16(10):1365-75. [PubMed: 15314038]  [MGI Ref ID J:93640]

Amiri P; Haak-Frendscho M; Robbins K; McKerrow JH; Stewart T; Jardieu P. 1994. Anti-immunoglobulin E treatment decreases worm burden and egg production in Schistosoma mansoni-infected normal and interferon gamma knockout mice. J Exp Med 180(1):43-51. [PubMed: 8006599]  [MGI Ref ID J:18740]

Arantes RM; Marche HH; Bahia MT; Cunha FQ; Rossi MA; Silva JS. 2004. Interferon-gamma-induced nitric oxide causes intrinsic intestinal denervation in Trypanosoma cruzi-infected mice. Am J Pathol 164(4):1361-8. [PubMed: 15039223]  [MGI Ref ID J:89108]

Bullen DV; Darwiche R; Metcalf D; Handman E; Alexander WS. 2001. Neutralization of interferon-gamma in neonatal SOCS1-/- mice prevents fatty degeneration of the liver but not subsequent fatal inflammatory disease. Immunology 104(1):92-8. [PubMed: 11576226]  [MGI Ref ID J:71691]

Campos MA; Closel M; Valente EP; Cardoso JE; Akira S; Alvarez-Leite JI; Ropert C; Gazzinelli RT. 2004. Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88. J Immunol 172(3):1711-8. [PubMed: 14734753]  [MGI Ref ID J:87693]

Chan WC; Duong TT; Yeung RS. 2004. Presence of IFN-gamma does not indicate its necessity for induction of coronary arteritis in an animal model of Kawasaki disease. J Immunol 173(5):3492-503. [PubMed: 15322214]  [MGI Ref ID J:92708]

Christensen JE; Wodarz D; Christensen JP; Thomsen AR. 2004. Perforin and IFN-gamma do not significantly regulate the virus-specific CD8+ T cell response in the absence of antiviral effector activity. Eur J Immunol 34(5):1389-94. [PubMed: 15114672]  [MGI Ref ID J:89390]

Cooper AM; Dalton DK; Stewart TA; Griffin JP; Russell DG; Orme IM. 1993. Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med 178(6):2243-7. [PubMed: 8245795]  [MGI Ref ID J:15723]

Dohi T; Fujihashi K; Kiyono H; Elson CO; McGhee JR. 2000. Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis. Gastroenterology 119(3):724-33. [PubMed: 10982767]  [MGI Ref ID J:64230]

Feng CG; Collazo-Custodio CM; Eckhaus M; Hieny S; Belkaid Y; Elkins K; Jankovic D; Taylor GA; Sher A. 2004. Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia. J Immunol 172(2):1163-8. [PubMed: 14707092]  [MGI Ref ID J:87364]

Fujigaki S; Saito K; Sekikawa K; Tone S; Takikawa O; Fujii H; Wada H; Noma A; Seishima M. 2001. Lipopolysaccharide induction of indoleamine 2,3-dioxygenase is mediated dominantly by an IFN-gamma-independent mechanism. Eur J Immunol 31(8):2313-8. [PubMed: 11477543]  [MGI Ref ID J:71158]

Hanada T; Yoshida H; Kato S; Tanaka K; Masutani K; Tsukada J; Nomura Y; Mimata H; Kubo M; Yoshimura A. 2003. Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity 19(3):437-50. [PubMed: 14499118]  [MGI Ref ID J:85811]

Hu C; Mayadas-Norton T; Tanaka K; Chan J; Salgame P. 2000. Mycobacterium tuberculosis infection in complement receptor 3-deficient mice. J Immunol 165(5):2596-602. [PubMed: 10946287]  [MGI Ref ID J:64055]

Kemp RA; Ronchese F. 2001. Tumor-specific tc1, but not tc2, cells deliver protective antitumor immunity. J Immunol 167(11):6497-502. [PubMed: 11714817]  [MGI Ref ID J:72797]

Lambert SL; Okada CY; Levy R. 2004. TCR vaccines against a murine T cell lymphoma: a primary role for antibodies of the IgG2c class in tumor protection. J Immunol 172(2):929-36. [PubMed: 14707065]  [MGI Ref ID J:87361]

Metcalf D; Alexander WS; Ryan PJ; Mifsud S; Di Rago L. 2001. Production of colony-stimulating factors and il-5 by organs from three types of mice with inflammatory disease due to loss of the suppressor of cytokine signaling-1. J Immunol 167(8):4661-7. [PubMed: 11591796]  [MGI Ref ID J:72058]

Murphy EA; Sathiyaseelan J; Parent MA; Zou B; Baldwin CL. 2001. Interferon-gamma is crucial for surviving a Brucella abortus infection in both resistant C57BL/6 and susceptible BALB/c mice. Immunology 103(4):511-8. [PubMed: 11529943]  [MGI Ref ID J:71148]

Murray HW; Lu CM; Brooks EB; Fichtl RE; DeVecchio JL; Heinzel FP. 2003. Modulation of T-cell costimulation as immunotherapy or immunochemotherapy in experimental visceral leishmaniasis. Infect Immun 71(11):6453-62. [PubMed: 14573667]  [MGI Ref ID J:86275]

Nance S; Cross R; Fitzpatrick E. 2004. Chemokine production during hypersensitivity pneumonitis. Eur J Immunol 34(3):677-85. [PubMed: 14991597]  [MGI Ref ID J:88361]

Nansen A; Marker O; Bartholdy C; Thomsen AR. 2000. CCR2+ and CCR5+ CD8+ T cells increase during viral infection and migrate to sites of infection. Eur J Immunol 30(7):1797-806. [PubMed: 10940868]  [MGI Ref ID J:63499]

Nguyen HH; van Ginkel FW; Vu HL; Novak MJ; McGhee JR; Mestecky J. 2000. Gamma interferon is not required for mucosal cytotoxic T-lymphocyte responses or heterosubtypic immunity to influenza A virus infection in mice. J Virol 74(12):5495-501. [PubMed: 10823854]  [MGI Ref ID J:62303]

Okamoto M; Kato S; Oizumi K; Kinoshita M; Inoue Y; Hoshino K; Akira S; McKenzie AN; Young HA; Hoshino T. 2002. Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia. Blood 99(4):1289-98. [PubMed: 11830478]  [MGI Ref ID J:74714]

Ponomarev ED; Novikova M; Yassai M; Szczepanik M; Gorski J; Dittel BN. 2004. Gamma delta T cell regulation of IFN-gamma production by central nervous system-infiltrating encephalitogenic T cells: correlation with recovery from experimental autoimmune encephalomyelitis. J Immunol 173(3):1587-95. [PubMed: 15265886]  [MGI Ref ID J:92038]

Scott MJ; Hoth JJ; Stagner MK; Gardner SA; Peyton JC; Cheadle WG. 2004. CD40-CD154 interactions between macrophages and natural killer cells during sepsis are critical for macrophage activation and are not interferon gamma dependent. Clin Exp Immunol 137(3):469-77. [PubMed: 15320895]  [MGI Ref ID J:92312]

Siegmund B; Sennello JA; Lehr HA; Senaldi G; Dinarello CA; Fantuzzi G. 2004. Frontline: Interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR gamma delta T cells and interleukin-18-binding protein. Eur J Immunol 34(9):2356-64. [PubMed: 15307168]  [MGI Ref ID J:91767]

Smith LM; Bonafonte MT; Mead JR. 2000. Cytokine expression and specific lymphocyte proliferation in two strains of Cryptosporidium parvum-infected gamma-interferon knockout mice. J Parasitol 86(2):300-7. [PubMed: 10780549]  [MGI Ref ID J:62349]

Townsend MJ; Weinmann AS; Matsuda JL; Salomon R; Farnham PJ; Biron CA; Gapin L; Glimcher LH. 2004. T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity 20(4):477-94. [PubMed: 15084276]  [MGI Ref ID J:89776]

Van Uden JH; Tran CH; Carson DA; Raz E. 2001. Type I interferon is required to mount an adaptive response to immunostimulatory DNA. Eur J Immunol 31(11):3281-90. [PubMed: 11745345]  [MGI Ref ID J:72586]

Wilson ME; Recker TJ; Rodriguez NE; Young BM; Burnell KK; Streit JA; Kline JN. 2002. The TGF-beta response to Leishmania chagasi in the absence of IL-12. Eur J Immunol 32(12):3556-65. [PubMed: 12516540]  [MGI Ref ID J:80857]

Ifng^tm1Ts related

Abromson-Leeman S; Bronson R; Luo Y; Berman M; Leeman R; Leeman J; Dorf M. 2004. T-cell properties determine disease site, clinical presentation, and cellular pathology of experimental autoimmune encephalomyelitis. Am J Pathol 165(5):1519-33. [PubMed: 15509523]  [MGI Ref ID J:109724]

Abromson-Leeman S; Ladell DS; Bronson RT; Dorf ME. 2007. Heterogeneity of EAE mediated by multiple distinct T-effector subsets. J Neuroimmunol 192(1-2):3-12. [PubMed: 17976744]  [MGI Ref ID J:128953]

Adams B; Nagy N; Paulart F; Vanderhaeghen ML; Goldman M; Flamand V. 2003. CD8+ T lymphocytes regulating Th2 pathology escape neonatal tolerization. J Immunol 171(10):5071-6. [PubMed: 14607904]  [MGI Ref ID J:117990]

Afanasyeva M; Georgakopoulos D; Belardi DF; Bedja D; Fairweather D; Wang Y; Kaya Z; Gabrielson KL; Rodriguez ER; Caturegli P; Kass DA; Rose NR. 2005. Impaired up-regulation of CD25 on CD4+ T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart failure. Proc Natl Acad Sci U S A 102(1):180-5. [PubMed: 15611472]  [MGI Ref ID J:95757]

Aguilar PV; Paessler S; Carrara AS; Baron S; Poast J; Wang E; Moncayo AC; Anishchenko M; Watts D; Tesh RB; Weaver SC. 2005. Variation in interferon sensitivity and induction among strains of eastern equine encephalitis virus. J Virol 79(17):11300-10. [PubMed: 16103182]  [MGI Ref ID J:101624]

Akhiani AA; Pappo J; Kabok Z; Schon K; Gao W; Franzen LE; Lycke N. 2002. Protection against Helicobacter pylori infection following immunization is IL-12-dependent and mediated by Th1 cells. J Immunol 169(12):6977-84. [PubMed: 12471132]  [MGI Ref ID J:118009]

Alayan J; Ivanovski S; Farah CS. 2007. Alveolar bone loss in T helper 1/T helper 2 cytokine-deficient mice. J Periodontal Res 42(2):97-103. [PubMed: 17305866]  [MGI Ref ID J:147935]

Alexander WS; Starr R; Fenner JE; Scott CL; Handman E; Sprigg NS; Corbin JE; Cornish AL; Darwiche R; Owczarek CM; Kay TW; Nicola NA; Hertzog PJ; Metcalf D; Hilton DJ. 1999. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98(5):597-608. [PubMed: 10490099]  [MGI Ref ID J:57474]

Aliberti JC; Souto JT; Marino AP; Lannes-Vieira J; Teixeira MM; Farber J; Gazzinelli RT; Silva JS. 2001. Modulation of chemokine production and inflammatory responses in interferon-gamma- and tumor necrosis factor-R1-deficient mice during Trypanosoma cruzi infection. Am J Pathol 158(4):1433-40. [PubMed: 11290561]  [MGI Ref ID J:68668]

Aly S; Laskay T; Mages J; Malzan A; Lang R; Ehlers S. 2007. Interferon-gamma-dependent mechanisms of mycobacteria-induced pulmonary immunopathology: the role of angiostasis and CXCR3-targeted chemokines for granuloma necrosis. J Pathol 212(3):295-305. [PubMed: 17534845]  [MGI Ref ID J:122272]

Ambati BK; Nozaki M; Singh N; Takeda A; Jani PD; Suthar T; Albuquerque RJ; Richter E; Sakurai E; Newcomb MT; Kleinman ME; Caldwell RB; Lin Q; Ogura Y; Orecchia A; Samuelson DA; Agnew DW; St Leger J; Green WR; Mahasreshti PJ; Curiel DT; Kwan D; Marsh H; Ikeda S; Leiper LJ; Collinson JM; Bogdanovich S; Khurana TS; Shibuya M; Baldwin ME; Ferrara N; Gerber HP; De Falco S; Witta J; Baffi JZ; Raisler BJ; Ambati J. 2006. Corneal avascularity is due to soluble VEGF receptor-1. Nature 443(7114):993-7. [PubMed: 17051153]  [MGI Ref ID J:114973]

Amiri P; Haak-Frendscho M; Robbins K; McKerrow JH; Stewart T; Jardieu P. 1994. Anti-immunoglobulin E treatment decreases worm burden and egg production in Schistosoma mansoni-infected normal and interferon gamma knockout mice. J Exp Med 180(1):43-51. [PubMed: 8006599]  [MGI Ref ID J:18740]

Andersen C; Jensen T; Nansen A; Marker O; Thomsen AR. 1999. CD4(+) T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-gamma or IL-4. Int Immunol 11(12):2035-42. [PubMed: 10590269]  [MGI Ref ID J:110491]

Andoh A; Masuda A; Kumazawa Y; Kasajima T. 2002. Serum antibody response and nasal lymphoid tissue (NALT) structure in the absence of IL-4 or IFN-gamma. Cytokine 20(3):107-12. [PubMed: 12453468]  [MGI Ref ID J:102594]

Andoh A; Masuda A; Yamakawa M; Kumazawa Y; Kasajima T. 2000. Absence of interleukin-4 enhances germinal center reaction in secondary immune response. Immunol Lett 73(1):35-41. [PubMed: 10963809]  [MGI Ref ID J:110473]

Andoh M; Zhang G; Russell-Lodrigue KE; Shive HR; Weeks BR; Samuel JE. 2007. T Cells Are Essential for Bacterial Clearance, and Gamma Interferon, Tumor Necrosis Factor Alpha, and B Cells Are Crucial for Disease Development in Coxiella burnetii Infection in Mice. Infect Immun 75(7):3245-55. [PubMed: 17438029]  [MGI Ref ID J:122426]

Andrade RM; Portillo JA; Wessendarp M; Subauste CS. 2005. CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates. Infect Immun 73(5):3115-23. [PubMed: 15845519]  [MGI Ref ID J:97614]

Andreasen SO; Christensen JE; Marker O; Thomsen AR. 2000. Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8+ effector T cell responses. J Immunol 164(7):3689-97. [PubMed: 10725727]  [MGI Ref ID J:123023]

Arantes RM; Marche HH; Bahia MT; Cunha FQ; Rossi MA; Silva JS. 2004. Interferon-gamma-induced nitric oxide causes intrinsic intestinal denervation in Trypanosoma cruzi-infected mice. Am J Pathol 164(4):1361-8. [PubMed: 15039223]  [MGI Ref ID J:89108]

Arens R; Baars PA; Jak M; Tesselaar K; van der Valk M; van Oers MH; van Lier RA. 2005. Cutting edge: CD95 maintains effector T cell homeostasis in chronic immune activation. J Immunol 174(10):5915-20. [PubMed: 15879081]  [MGI Ref ID J:98994]

Arens R; Nolte MA; Tesselaar K; Heemskerk B; Reedquist KA; van Lier RA; van Oers MH. 2004. Signaling through CD70 regulates B cell activation and IgG production. J Immunol 173(6):3901-8. [PubMed: 15356138]  [MGI Ref ID J:92744]

Arora S; Hernandez Y; Erb-Downward JR; McDonald RA; Toews GB; Huffnagle GB. 2005. Role of IFN-gamma in regulating T2 immunity and the development of alternatively activated macrophages during allergic bronchopulmonary mycosis. J Immunol 174(10):6346-56. [PubMed: 15879135]  [MGI Ref ID J:99045]

Arsenijevic D; Clavel S; Sanchis D; Plamondon J; Huang Q; Ricquier D; Rouger L; Richard D. 2007. Induction of Ucp2 expression in brain phagocytes and neurons following murine toxoplasmosis: an essential role of IFN-gamma and an association with negative energy balance. J Neuroimmunol 186(1-2):121-32. [PubMed: 17467814]  [MGI Ref ID J:124552]

Artis D; Villarino A; Silverman M; He W; Thornton EM; Mu S; Summer S; Covey TM; Huang E; Yoshida H; Koretzky G; Goldschmidt M; Wu GD; de Sauvage F; Miller HR; Saris CJ; Scott P; Hunter CA. 2004. The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. J Immunol 173(9):5626-34. [PubMed: 15494513]  [MGI Ref ID J:93739]

Ashkar AA; Croy BA. 1999. Interferon-gamma contributes to the normalcy of murine pregnancy. Biol Reprod 61(2):493-502. [PubMed: 10411532]  [MGI Ref ID J:56503]

Ashkar AA; Di Santo JP; Croy BA. 2000. Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy [see comments] J Exp Med 192(2):259-70. [PubMed: 10899912]  [MGI Ref ID J:63645]

Badovinac VP; Harty JT. 2000. Adaptive immunity and enhanced CD8+ T cell response to Listeria monocytogenes in the absence of perforin and IFN-gamma. J Immunol 164(12):6444-52. [PubMed: 10843700]  [MGI Ref ID J:83175]

Badovinac VP; Tvinnereim AR; Harty JT. 2000. Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma. Science 290(5495):1354-8. [PubMed: 11082062]  [MGI Ref ID J:83176]

Bai Y; Liu R; Huang D; La Cava A; Tang YY; Iwakura Y; Campagnolo DI; Vollmer TL; Ransohoff RM; Shi FD. 2008. CCL2 recruitment of IL-6-producing CD11b(+) monocytes to the draining lymph nodes during the initiation of Th17-dependent B cell-mediated autoimmunity. Eur J Immunol 38(7):1877-88. [PubMed: 18581322]  [MGI Ref ID J:137386]

Balish E; Wagner RD; Vazquez-Torres A; Pierson C; Warner T. 1998. Candidiasis in interferon-gamma knockout (IFN-gamma-/-) mice. J Infect Dis 178(2):478-87. [PubMed: 9697730]  [MGI Ref ID J:120514]

Balomenos D; Rumold R; Theofilopoulos AN. 1998. Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J Clin Invest 101(2):364-71. [PubMed: 9435308]  [MGI Ref ID J:45391]

Bao S; Beagley KW; France MP; Shen J; Husband AJ. 2000. Interferon-gamma plays a critical role in intestinal immunity against Salmonella typhimurium infection. Immunology 99(3):464-72. [PubMed: 10712678]  [MGI Ref ID J:61050]

Barber EM; Fazzari M; Pollard JW. 2005. Th1 cytokines are essential for placental immunity to Listeria monocytogenes. Infect Immun 73(10):6322-31. [PubMed: 16177303]  [MGI Ref ID J:104232]

Barr TA; Brown S; Mastroeni P; Gray D. 2009. B cell intrinsic MyD88 signals drive IFN-gamma production from T cells and control switching to IgG2c. J Immunol 183(2):1005-12. [PubMed: 19542370]  [MGI Ref ID J:151505]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX30

Colony Maintenance

Mating System	Homozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information	LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

Pair Pricing: Price may vary depending on the age of the males and females available for shipment. The price displayed is for a male and female at six weeks of age. Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. This strain is included in the Induced Mutant Resource Colony collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	000664 C57BL/6J
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

      Purchasing Information
      JAX^® Mice Orders
      Surgical Services

Contact Information
Orders & Technical Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.