Strain Name:

B6.129S7-Selptm1Bay/J

Stock Number:

002289

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Mice homozygous for Selptm1Bay show a deficit in leukocyte rolling and delayed neutrophil extravasation in response to intraperitoneal injections of thioglycollate. The strain can be used as model for human leukocyte adhesion deficiency I syndrome.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain 129S7 via AB2.1 ES cell line
GenerationN10F40 (27-DEC-13)
Generation Definitions
 
Donating InvestigatorDr. Arthur Beaudet,   Baylor College of Medicine

Appearance
black
Related Genotype: a/a

Description
Mice homozygous for the Selptm1Bay mutation are viable and fertile. Homoyzgous mutant mice show a deficit in leukocyte rolling and delayed neutrophil extravasation in response to intraperitoneal injections of thioglycollate. Neutrophil count is elevated (2-3-fold). Circulating lymphocyte and monocyte counts are normal. 60-70% reduction in neutrophil emigration into the peritoneum during Streptococcus pneumoniae-induced peritonitis is reduced 60-70%. It can be used as model for human leukocyte adhesion deficiency I syndrome (characterized by elevated levels of circulating leukocytes and impaired leukocyte extravasation to sites of inflammation or infection).

Development
A neomycin resistance gene was inserted in the reverse orientation to delete a 4.5kb region containing exons 3 through 5. RT-PCR analysis of lung RNA isolated from homozygous mutant mice showed a transcript 682 base pairs shorter than normal. A clone with the correctly targeted gene was injected into C57BL/6 embryos. The strain has been backcrossed for 10 generations to C57BL/6J.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Selptm1Bay allele
002285   B6.129S7-Icam1tm1Bay Selptm1Bay/J
View Strains carrying   Selptm1Bay     (1 strain)

View Strains carrying other alleles of Selp     (12 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
IgE Responsiveness, Atopic; IGER   (SELP)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Selptm1Bay/Selptm1Bay

        B6.129S7-Selptm1Bay/J
  • immune system phenotype
  • abnormal T cell physiology
    • T lymphocyte migration and accumulation into cutaneous inflammatory regions induced by a combination of IFN-gamma and TNF-alpha is inhibited by about 25%, however IFN-gamma, TNF-alpha, and ConA, has no effect on T cell infiltration   (MGI Ref ID J:113536)
  • hematopoietic system phenotype
  • abnormal T cell physiology
    • T lymphocyte migration and accumulation into cutaneous inflammatory regions induced by a combination of IFN-gamma and TNF-alpha is inhibited by about 25%, however IFN-gamma, TNF-alpha, and ConA, has no effect on T cell infiltration   (MGI Ref ID J:113536)

Selptm1Bay/Selptm1Bay

        either: B6.129S7-Selptm1Bay or (involves: 129S7/SvEvBrd * C57BL/6)
  • hematopoietic system phenotype
  • abnormal leukocyte tethering or rolling
    • after surgery to exteriorize cremaster muscle, mice do not display leukocyte rolling for the first hour, but a significant amount of rolling is detected after 2 hours (~8% rolling leukocyte flux)   (MGI Ref ID J:31374)
    • leukocytes show intermittent interactions with endothelium causing an increase in rolling velocity to ~129 um/second (~35 um/second in wild-type)   (MGI Ref ID J:31374)
    • treatment with Tnfa (tumor necrosis factor alpha) reduces rolling velocity to ~5 um/second   (MGI Ref ID J:31374)
  • increased leukocyte cell number
    • systemic leukocyte counts are ~9800/ul (~61% neutrophils, ~37% lymphocytes) compared to wild-type counts of ~5660/ul (53% neutrophils, 46% lymphocytes)   (MGI Ref ID J:31374)
  • immune system phenotype
  • abnormal leukocyte tethering or rolling
    • after surgery to exteriorize cremaster muscle, mice do not display leukocyte rolling for the first hour, but a significant amount of rolling is detected after 2 hours (~8% rolling leukocyte flux)   (MGI Ref ID J:31374)
    • leukocytes show intermittent interactions with endothelium causing an increase in rolling velocity to ~129 um/second (~35 um/second in wild-type)   (MGI Ref ID J:31374)
    • treatment with Tnfa (tumor necrosis factor alpha) reduces rolling velocity to ~5 um/second   (MGI Ref ID J:31374)
  • increased leukocyte cell number
    • systemic leukocyte counts are ~9800/ul (~61% neutrophils, ~37% lymphocytes) compared to wild-type counts of ~5660/ul (53% neutrophils, 46% lymphocytes)   (MGI Ref ID J:31374)
  • cellular phenotype
  • abnormal leukocyte tethering or rolling
    • after surgery to exteriorize cremaster muscle, mice do not display leukocyte rolling for the first hour, but a significant amount of rolling is detected after 2 hours (~8% rolling leukocyte flux)   (MGI Ref ID J:31374)
    • leukocytes show intermittent interactions with endothelium causing an increase in rolling velocity to ~129 um/second (~35 um/second in wild-type)   (MGI Ref ID J:31374)
    • treatment with Tnfa (tumor necrosis factor alpha) reduces rolling velocity to ~5 um/second   (MGI Ref ID J:31374)

Selptm1Bay/Selptm1Bay

        B6.129S7-Selptm1Bay
  • immune system phenotype
  • decreased mast cell number
    • during the chronic phase of antigen exposure   (MGI Ref ID J:121083)
  • decreased susceptibility to type IV hypersensitivity reaction
    • chronic inflammation in response to oxazolone exposure is inhibited compared to in similarly treated wild-type mice   (MGI Ref ID J:121083)
    • however, acute inflammation in response to oxazolone exposure is normal   (MGI Ref ID J:121083)
  • hematopoietic system phenotype
  • decreased mast cell number
    • during the chronic phase of antigen exposure   (MGI Ref ID J:121083)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Selptm1Bay/Selptm1Bay

        involves: 129S7/SvEvBrd * C57BL/6J
  • immune system phenotype
  • abnormal leukocyte migration
    • Streptococcus pneumoniae induced peritonitis reduced neutrophil emigration into peritoneum by 61-69% after 2-4 hours   (MGI Ref ID J:24239)
  • abnormal spleen morphology
    • increase in splenic thrombosis and necrosis in contrast to controls following infection with S. pneumoniae   (MGI Ref ID J:101979)
  • eye inflammation
    • panophthalmitis observed in 8% of mice following infection with S. pneumoniae   (MGI Ref ID J:101979)
  • increased leukocyte cell number
    • elevated peripheral leukocyte count in contrast to controls following infection with S. pneumoniae   (MGI Ref ID J:101979)
    • increased neutrophil cell number
      • mild neutrophilia in contrast to controls following infection with S. pneumoniae   (MGI Ref ID J:101979)
      • 2-3 fold increase in numbers of circulating neutrophils   (MGI Ref ID J:24239)
  • increased susceptibility to bacterial infection
    • severity and duration of morbidity higher than wild-type after infection with Streptococcus pneumoniae   (MGI Ref ID J:101979)
    • survival rate was 19% in contrast to a 57% rate for wild-type mice   (MGI Ref ID J:101979)
    • decreased ability to clear bacteremia among survivors   (MGI Ref ID J:101979)
  • behavior/neurological phenotype
  • abnormal pilomotor reflex
    • observed following infection with S. pneumoniae   (MGI Ref ID J:101979)
  • head tilt
    • observed following infection with S. pneumoniae   (MGI Ref ID J:101979)
  • hypoactivity
    • observed following infection with S. pneumoniae   (MGI Ref ID J:101979)
  • spinning
    • observed following infection with S. pneumoniae   (MGI Ref ID J:101979)
  • tremors
    • observed following infection with S. pneumoniae   (MGI Ref ID J:101979)
  • liver/biliary system phenotype
  • hepatic necrosis
    • higher incidence in contrast to controls following infection with S. pneumoniae   (MGI Ref ID J:101979)
  • growth/size/body phenotype
  • weight loss
    • observed 48 hours post-infection with S. pneumoniae   (MGI Ref ID J:101979)
  • vision/eye phenotype
  • eye inflammation
    • panophthalmitis observed in 8% of mice following infection with S. pneumoniae   (MGI Ref ID J:101979)
  • hematopoietic system phenotype
  • abnormal leukocyte migration
    • Streptococcus pneumoniae induced peritonitis reduced neutrophil emigration into peritoneum by 61-69% after 2-4 hours   (MGI Ref ID J:24239)
  • abnormal spleen morphology
    • increase in splenic thrombosis and necrosis in contrast to controls following infection with S. pneumoniae   (MGI Ref ID J:101979)
  • increased leukocyte cell number
    • elevated peripheral leukocyte count in contrast to controls following infection with S. pneumoniae   (MGI Ref ID J:101979)
    • increased neutrophil cell number
      • mild neutrophilia in contrast to controls following infection with S. pneumoniae   (MGI Ref ID J:101979)
      • 2-3 fold increase in numbers of circulating neutrophils   (MGI Ref ID J:24239)
  • cellular phenotype
  • abnormal leukocyte migration
    • Streptococcus pneumoniae induced peritonitis reduced neutrophil emigration into peritoneum by 61-69% after 2-4 hours   (MGI Ref ID J:24239)

Selptm1Bay/Selptm1Bay

        D1.129S7(B6J)-Selptm1Bay
  • skeleton phenotype
  • increased susceptibility to induced arthritis
    • accelerated incidence of induced arthritis, 23% compared to 2% of DBA/1 mice by 28 days   (MGI Ref ID J:57086)
    • increase in number of affected paws   (MGI Ref ID J:57086)
    • consistently higher arthritis severity scores as determined by inflammation, paw/digit distortion and ankylosis   (MGI Ref ID J:57086)
    • onset of arthritis occurs as early as day 14 with a median onset of 34 days   (MGI Ref ID J:57086)
  • immune system phenotype
  • abnormal cytokine secretion
    • increased levels of IL10 and IL5 measured in stimulated splenocytes   (MGI Ref ID J:57086)
    • decreased levels of IL2 and IL4 measured in stimulated splenocytes   (MGI Ref ID J:57086)
  • increased IgG level
    • increased levels of serum IgG anti-type II collagen antibody measured in collagen immunized mice as compared to immunized DBA/1 mice   (MGI Ref ID J:57086)
  • increased susceptibility to induced arthritis
    • accelerated incidence of induced arthritis, 23% compared to 2% of DBA/1 mice by 28 days   (MGI Ref ID J:57086)
    • increase in number of affected paws   (MGI Ref ID J:57086)
    • consistently higher arthritis severity scores as determined by inflammation, paw/digit distortion and ankylosis   (MGI Ref ID J:57086)
    • onset of arthritis occurs as early as day 14 with a median onset of 34 days   (MGI Ref ID J:57086)
  • hematopoietic system phenotype
  • increased IgG level
    • increased levels of serum IgG anti-type II collagen antibody measured in collagen immunized mice as compared to immunized DBA/1 mice   (MGI Ref ID J:57086)

Selptm1Bay/Selptm1Bay

        involves: 129S7/SvEvBrd * C57BL/6
  • hematopoietic system phenotype
  • increased neutrophil cell number
    • circulating neutrophils are increased in mutants and this increases with age of mice   (MGI Ref ID J:112286)
  • immune system phenotype
  • increased neutrophil cell number
    • circulating neutrophils are increased in mutants and this increases with age of mice   (MGI Ref ID J:112286)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Selptm1Bay related

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Inflammation

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Selptm1Bay
Allele Name targeted mutation 1, Baylor College of Medicine
Allele Type Targeted (Null/Knockout)
Common Name(s) CD62ELP-; CD62P-; P-; P-sel-; P-selectin-;
Mutation Made ByDr. Arthur Beaudet,   Baylor College of Medicine
Strain of Origin129S7/SvEvBrd-Hprt
ES Cell Line NameAB2.1
ES Cell Line Strain129S7/SvEvBrd-Hprt
Gene Symbol and Name Selp, selectin, platelet
Chromosome 1
Gene Common Name(s) CD62; CD62P; GMP140; GRMP; Grmp; LECAM3; P-selectin; PADGEM; PSEL; PSELECT; granulocyte membrane protein;
Molecular Note A neomycin resistance gene was inserted in the reverse orientation to delete a 4.5kb region containing exons 3 through 5. RT-PCR analysis of lung RNA isolated from homozygous mutant mice showed a transcript 682 base pairs shorter than normal. Immunohistochemical staining showed a lack of encoded protein on both endothelium and platelets. [MGI Ref ID J:24239]

Genotyping

Genotyping Information

Genotyping Protocols

Selptm1Bay, Fast MCA
Selptm1Bay, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Bullard DC; Qin L; Lorenzo I; Quinlin WM; Doyle NA; Bosse R; Vestweber D; Doerschuk CM; Beaudet AL. 1995. P-selectin/ICAM-1 double mutant mice: acute emigration of neutrophils into the peritoneum is completely absent but is normal into pulmonary alveoli [see comments] J Clin Invest 95(4):1782-8. [PubMed: 7535798]  [MGI Ref ID J:24239]

Additional References

Bullard DC; Kunkel EJ; Kubo H; Hicks MJ; Lorenzo I; Doyle NA; Doerschuk CM; Ley K; Beaudet AL. 1996. Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J Exp Med 183(5):2329-36. [PubMed: 8642341]  [MGI Ref ID J:33135]

Bullard DC; Mobley JM; Justen JM; Sly LM; Chosay JG; Dunn CJ; Lindsey JR; Beaudet AL; Staite ND. 1999. Acceleration and increased severity of collagen-induced arthritis in P-selectin mutant mice. J Immunol 163(5):2844-9. [PubMed: 10453030]  [MGI Ref ID J:57086]

Doerschuk CM; Quinlan WM; Doyle NA; Bullard DC; Vestweber D; Jones ML; Takei F; Ward PA; Beaudet AL. 1996. The role of P-selectin and ICAM-1 in acute lung injury as determined using blocking antibodies and mutant mice. J Immunol 157(10):4609-14. [PubMed: 8906840]  [MGI Ref ID J:37197]

Huo Y; Schober A; Forlow SB; Smith DF; Hyman MC; Jung S; Littman DR; Weber C; Ley K. 2003. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med 9(1):61-7. [PubMed: 12483207]  [MGI Ref ID J:81164]

Jung U; Ley K. 1999. Mice lacking two or all three selectins demonstrate overlapping and distinct functions for each selectin. J Immunol 162(11):6755-62. [PubMed: 10352295]  [MGI Ref ID J:55032]

Kamochi M; Kamochi F; Kim YB; Sawh S; Sanders JM; Sarembock I; Green S; Young JS; Ley K; Fu SM; Rose CE Jr. 1999. P-selectin and ICAM-1 mediate endotoxin-induced neutrophil recruitment and injury to the lung and liver. Am J Physiol 277(2 Pt 1):L310-9. [PubMed: 10444525]  [MGI Ref ID J:56844]

Kohm AP; Miller SD. 2003. Role of ICAM-1 and P-selectin expression in the development and effector function of CD4+CD25+regulatory T cells. J Autoimmun 21(3):261-71. [PubMed: 14599851]  [MGI Ref ID J:86435]

Sun G; Chang WL; Li J; Berney SM; Kimpel D; van der Heyde HC. 2003. Inhibition of platelet adherence to brain microvasculature protects against severe Plasmodium berghei malaria. Infect Immun 71(11):6553-61. [PubMed: 14573677]  [MGI Ref ID J:86276]

Tesfaigzi Y; Fischer MJ; Daheshia M; Green FH; De Sanctis GT; Wilder JA. 2002. Bax is crucial for IFN-gamma-induced resolution of allergen-induced mucus cell metaplasia. J Immunol 169(10):5919-25. [PubMed: 12421976]  [MGI Ref ID J:80074]

Selptm1Bay related

Baker PJ; DuFour L; Dixon M; Roopenian DC. 2000. Adhesion molecule deficiencies increase Porphyromonas gingivalis-induced alveolar bone loss in mice. Infect Immun 68(6):3103-7. [PubMed: 10816450]  [MGI Ref ID J:62266]

Bartholdy C; Marker O; Thomsen AR. 2000. Migration of activated CD8(+) T lymphocytes to sites of viral infection does not require endothelial selectins. Blood 95(4):1362-9. [PubMed: 10666212]  [MGI Ref ID J:110273]

Bonasio R; Scimone ML; Schaerli P; Grabie N; Lichtman AH; von Andrian UH. 2006. Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nat Immunol 7(10):1092-100. [PubMed: 16951687]  [MGI Ref ID J:112629]

Bonig H; Priestley GV; Oehler V; Papayannopoulou T. 2007. Hematopoietic progenitor cells (HPC) from mobilized peripheral blood display enhanced migration and marrow homing compared to steady-state bone marrow HPC. Exp Hematol 35(2):326-34. [PubMed: 17258081]  [MGI Ref ID J:123189]

Briaud SA; Ding ZM; Michael LH; Entman ML; Daniel S; Ballantyne CM. 2001. Leukocyte trafficking and myocardial reperfusion injury in ICAM-1/P-selectin-knockout mice. Am J Physiol Heart Circ Physiol 280(1):H60-7. [PubMed: 11123218]  [MGI Ref ID J:68056]

Broide DH; Humber D; Sullivan S; Sriramarao P. 1998. Inhibition of eosinophil rolling and recruitment in P-selectin- and intracellular adhesion molecule-1-deficient mice [published erratum appears in Blood 1998 Jul 1;92(1):343] Blood 91(8):2847-56. [PubMed: 9531595]  [MGI Ref ID J:47461]

Broide DH; Sullivan S; Gifford T; Sriramarao P. 1998. Inhibition of pulmonary eosinophilia in P-selectin- and ICAM-1-deficient mice. Am J Respir Cell Mol Biol 18(2):218-25. [PubMed: 9476909]  [MGI Ref ID J:114264]

Bullard DC; Kunkel EJ; Kubo H; Hicks MJ; Lorenzo I; Doyle NA; Doerschuk CM; Ley K; Beaudet AL. 1996. Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J Exp Med 183(5):2329-36. [PubMed: 8642341]  [MGI Ref ID J:33135]

Bullard DC; Mobley JM; Justen JM; Sly LM; Chosay JG; Dunn CJ; Lindsey JR; Beaudet AL; Staite ND. 1999. Acceleration and increased severity of collagen-induced arthritis in P-selectin mutant mice. J Immunol 163(5):2844-9. [PubMed: 10453030]  [MGI Ref ID J:57086]

Carlow DA; Ziltener HJ. 2006. CD43 deficiency has no impact in competitive in vivo assays of neutrophil or activated T cell recruitment efficiency. J Immunol 177(9):6450-9. [PubMed: 17056577]  [MGI Ref ID J:140506]

Carrithers MD; Visintin I; Viret C; Janeway CS Jr. 2002. Role of genetic background in P selectin-dependent immune surveillance of the central nervous system. J Neuroimmunol 129(1-2):51-7. [PubMed: 12161020]  [MGI Ref ID J:102957]

Collins RG; Jung U; Ramirez M; Bullard DC; Hicks MJ; Smith CW; Ley K; Beaudet AL. 2001. Dermal and pulmonary inflammatory disease in E-selectin and P-selectin double-null mice is reduced in triple-selectin-null mice. Blood 98(3):727-35. [PubMed: 11468173]  [MGI Ref ID J:70682]

Collins RG; Velji R; Guevara NV; Hicks MJ; Chan L; Beaudet AL. 2000. P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice. J Exp Med 191(1):189-94. [PubMed: 10620617]  [MGI Ref ID J:59249]

Curtis JL; Sonstein J; Craig RA; Todt JC; Knibbs RN; Polak T; Bullard DC; Stoolman LM. 2002. Subset-specific reductions in lung lymphocyte accumulation following intratracheal antigen challenge in endothelial selectin-deficient mice. J Immunol 169(5):2570-9. [PubMed: 12193727]  [MGI Ref ID J:120687]

Deban L; Russo RC; Sironi M; Moalli F; Scanziani M; Zambelli V; Cuccovillo I; Bastone A; Gobbi M; Valentino S; Doni A; Garlanda C; Danese S; Salvatori G; Sassano M; Evangelista V; Rossi B; Zenaro E; Constantin G; Laudanna C; Bottazzi B; Mantovani A. 2010. Regulation of leukocyte recruitment by the long pentraxin PTX3. Nat Immunol 11(4):328-34. [PubMed: 20208538]  [MGI Ref ID J:158981]

Doerschuk CM; Quinlan WM; Doyle NA; Bullard DC; Vestweber D; Jones ML; Takei F; Ward PA; Beaudet AL. 1996. The role of P-selectin and ICAM-1 in acute lung injury as determined using blocking antibodies and mutant mice. J Immunol 157(10):4609-14. [PubMed: 8906840]  [MGI Ref ID J:37197]

Eppihimer MJ; Russell J; Anderson DC; Wolitzky BA; Granger DN. 1997. Endothelial cell adhesion molecule expression in gene-targeted mice. Am J Physiol 273(4 Pt 2):H1903-8. [PubMed: 9362259]  [MGI Ref ID J:43907]

Eriksson EE. 2008. No detectable endothelial- or leukocyte-derived L-selectin ligand activity on the endothelium in inflamed cremaster muscle venules. J Leukoc Biol 84(1):93-103. [PubMed: 18381812]  [MGI Ref ID J:137752]

Evangelista V; Manarini S; Coller BS; Smyth SS. 2003. Role of P-selectin, beta2-integrins, and Src tyrosine kinases in mouse neutrophil-platelet adhesion. J Thromb Haemost 1(5):1048-54. [PubMed: 12871376]  [MGI Ref ID J:104023]

Evangelista V; Pamuklar Z; Piccoli A; Manarini S; Dell'elba G; Pecce R; Martelli N; Federico L; Rojas M; Berton G; Lowell CA; Totani L; Smyth SS. 2007. Src family kinases mediate neutrophil adhesion to adherent platelets. Blood 109(6):2461-9. [PubMed: 17095622]  [MGI Ref ID J:145358]

Falati S; Liu Q; Gross P; Merrill-Skoloff G; Chou J; Vandendries E; Celi A; Croce K; Furie BC; Furie B. 2003. Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin. J Exp Med 197(11):1585-98. [PubMed: 12782720]  [MGI Ref ID J:83734]

Forlow SB; Foley PL; Ley K. 2002. Severely reduced neutrophil adhesion and impaired host defense against fecal and commensal bacteria in CD18-/-P-selectin-/- double null mice. FASEB J 16(12):1488-96. [PubMed: 12374771]  [MGI Ref ID J:120011]

Forlow SB; Ley K. 2001. Selectin-independent leukocyte rolling and adhesion in mice deficient in E-, P-, and L-selectin and ICAM-1. Am J Physiol Heart Circ Physiol 280(2):H634-41. [PubMed: 11158961]  [MGI Ref ID J:68044]

Forlow SB; White EJ; Thomas KL; Bagby GJ; Foley PL; Ley K. 2002. T cell requirement for development of chronic ulcerative dermatitis in e- and p-selectin-deficient mice. J Immunol 169(9):4797-804. [PubMed: 12391189]  [MGI Ref ID J:79774]

Fujita T; Fujimoto M; Matsushita T; Shimada Y; Hasegawa M; Kuwano Y; Ogawa F; Takehara K; Sato S. 2007. Phase-Dependent Roles of E-Selectin during Chronic Contact Hypersensitivity Responses. Am J Pathol 170(5):1649-58. [PubMed: 17456770]  [MGI Ref ID J:121083]

Gossens K; Naus S; Corbel SY; Lin S; Rossi FM; Kast J; Ziltener HJ. 2009. Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25. J Exp Med 206(4):761-78. [PubMed: 19289576]  [MGI Ref ID J:147871]

Graciano AL; Bryant DD; White DJ; Horton J; Bowles NE; Giroir BP. 2001. Targeted disruption of ICAM-1, P-selectin genes improves cardiac function and survival in TNF-alpha transgenic mice. Am J Physiol Heart Circ Physiol 280(4):H1464-71. [PubMed: 11247755]  [MGI Ref ID J:108278]

Gregory JL; Morand EF; McKeown SJ; Ralph JA; Hall P; Yang YH; McColl SR; Hickey MJ. 2006. Macrophage migration inhibitory factor induces macrophage recruitment via CC chemokine ligand 2. J Immunol 177(11):8072-9. [PubMed: 17114481]  [MGI Ref ID J:140686]

Hafezi-Moghadam A; Thomas KL; Prorock AJ; Huo Y; Ley K. 2001. L-selectin shedding regulates leukocyte recruitment. J Exp Med 193(7):863-72. [PubMed: 11283159]  [MGI Ref ID J:120579]

He X; Schoeb TR; Panoskaltsis-Mortari A; Zinn KR; Kesterson RA; Zhang J; Samuel S; Hicks MJ; Hickey MJ; Bullard DC. 2006. Deficiency of P-selectin or P-selectin glycoprotein ligand-1 leads to accelerated development of glomerulonephritis and increased expression of CC chemokine ligand 2 in lupus-prone mice. J Immunol 177(12):8748-56. [PubMed: 17142777]  [MGI Ref ID J:127199]

Hickey MJ; Bullard DC; Issekutz A; James WG. 2002. Leukocyte-endothelial cell interactions are enhanced in dermal postcapillary venules of MRL/fas(lpr) (lupus-prone) mice: roles of P- and E-selectin. J Immunol 168(9):4728-36. [PubMed: 11971023]  [MGI Ref ID J:126009]

Hickey MJ; Granger DN; Kubes P. 1999. Molecular mechanisms underlying IL-4-induced leukocyte recruitment in vivo: a critical role for the alpha 4 integrin. J Immunol 163(6):3441-8. [PubMed: 10477616]  [MGI Ref ID J:119200]

Hicks AE; Abbitt KB; Dodd P; Ridger VC; Hellewell PG; Norman KE. 2005. The anti-inflammatory effects of a selectin ligand mimetic, TBC-1269, are not a result of competitive inhibition of leukocyte rolling in vivo. J Leukoc Biol 77(1):59-66. [PubMed: 15466915]  [MGI Ref ID J:95144]

Horikawa M; Fujimoto M; Hasegawa M; Matsushita T; Hamaguchi Y; Kawasuji A; Matsushita Y; Fujita T; Ogawa F; Takehara K; Steeber DA; Sato S. 2006. E- and P-selectins synergistically inhibit bleomycin-induced pulmonary fibrosis. Am J Pathol 169(3):740-9. [PubMed: 16936251]  [MGI Ref ID J:112363]

Huo Y; Schober A; Forlow SB; Smith DF; Hyman MC; Jung S; Littman DR; Weber C; Ley K. 2003. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med 9(1):61-7. [PubMed: 12483207]  [MGI Ref ID J:81164]

Ishii T; Fujita T; Matsushita T; Yanaba K; Hasegawa M; Nakashima H; Ogawa F; Shimizu K; Takehara K; Tedder TF; Sato S; Fujimoto M. 2009. Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction. Am J Pathol 174(6):2225-33. [PubMed: 19389931]  [MGI Ref ID J:148778]

James WG; Bullard DC; Hickey MJ. 2003. Critical role of the alpha 4 integrin/VCAM-1 pathway in cerebral leukocyte trafficking in lupus-prone MRL/fas(lpr) mice. J Immunol 170(1):520-7. [PubMed: 12496439]  [MGI Ref ID J:127282]

Jones SP; Trocha SD; Strange MB; Granger DN; Kevil CG; Bullard DC; Lefer DJ. 2000. Leukocyte and endothelial cell adhesion molecules in a chronic murine model of myocardial reperfusion injury Am J Physiol Heart Circ Physiol 279(5):H2196-201. [PubMed: 11045953]  [MGI Ref ID J:65658]

Jung U; Ley K. 1999. Mice lacking two or all three selectins demonstrate overlapping and distinct functions for each selectin. J Immunol 162(11):6755-62. [PubMed: 10352295]  [MGI Ref ID J:55032]

Jung U; Ramos CL; Bullard DC; Ley K. 1998. Gene-targeted mice reveal importance of L-selectin-dependent rolling for neutrophil adhesion. Am J Physiol 274(5 Pt 2):H1785-91. [PubMed: 9612391]  [MGI Ref ID J:47723]

Kamochi M; Kamochi F; Kim YB; Sawh S; Sanders JM; Sarembock I; Green S; Young JS; Ley K; Fu SM; Rose CE Jr. 1999. P-selectin and ICAM-1 mediate endotoxin-induced neutrophil recruitment and injury to the lung and liver. Am J Physiol 277(2 Pt 1):L310-9. [PubMed: 10444525]  [MGI Ref ID J:56844]

Kerfoot SM; Long EM; Hickey MJ; Andonegui G; Lapointe BM; Zanardo RC; Bonder C; James WG; Robbins SM; Kubes P. 2004. TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease. J Immunol 173(11):7070-7. [PubMed: 15557205]  [MGI Ref ID J:94363]

Kerfoot SM; Norman MU; Lapointe BM; Bonder CS; Zbytnuik L; Kubes P. 2006. Reevaluation of P-selectin and alpha 4 integrin as targets for the treatment of experimental autoimmune encephalomyelitis. J Immunol 176(10):6225-34. [PubMed: 16670333]  [MGI Ref ID J:131757]

Kim MH; Carter PR; Harris NR. 2007. P-selectin-mediated adhesion impairs endothelium-dependent arteriolar dilation in hypercholesterolemic mice. Am J Physiol Heart Circ Physiol 292(1):H632-8. [PubMed: 16980348]  [MGI Ref ID J:119942]

Kohm AP; Miller SD. 2003. Role of ICAM-1 and P-selectin expression in the development and effector function of CD4+CD25+regulatory T cells. J Autoimmun 21(3):261-71. [PubMed: 14599851]  [MGI Ref ID J:86435]

Komura K; Hasegawa M; Hamaguchi Y; Saito E; Kaburagi Y; Yanaba K; Kawara S; Takehara K; Seki M; Steeber DA; Tedder TF; Sato S. 2003. Ultraviolet light exposure suppresses contact hypersensitivity by abrogating endothelial intercellular adhesion molecule-1 up-regulation at the elicitation site. J Immunol 171(6):2855-62. [PubMed: 12960307]  [MGI Ref ID J:85377]

Koupenova M; Vitseva O; MacKay CR; Beaulieu LM; Benjamin EJ; Mick E; Kurt-Jones EA; Ravid K; Freedman JE. 2014. Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis. Blood 124(5):791-802. [PubMed: 24755410]  [MGI Ref ID J:213746]

Kulidjian AA; Issekutz AC; Issekutz TB. 2002. Differential role of E-selectin and P-selectin in T lymphocyte migration to cutaneous inflammatory reactions induced by cytokines. Int Immunol 14(7):751-60. [PubMed: 12096034]  [MGI Ref ID J:113536]

Kuligowski MP; Kitching AR; Hickey MJ. 2006. Leukocyte recruitment to the inflamed glomerulus: a critical role for platelet-derived P-selectin in the absence of rolling. J Immunol 176(11):6991-9. [PubMed: 16709860]  [MGI Ref ID J:131787]

Kunkel EJ; Chomas JE; Ley K. 1998. Role of primary and secondary capture for leukocyte accumulation in vivo. Circ Res 82(1):30-8. [PubMed: 9440702]  [MGI Ref ID J:114235]

Kunkel EJ; Jung U; Bullard DC; Norman KE; Wolitzky BA; Vestweber D; Beaudet AL; Ley K. 1996. Absence of trauma-induced leukocyte rolling in mice deficient in both P-selectin and intercellular adhesion molecule 1. J Exp Med 183(1):57-65. [PubMed: 8551244]  [MGI Ref ID J:31374]

Kupatt C; Wichels R; Horstkotte J; Krombach F; Habazettl H; Boekstegers P. 2002. Molecular mechanisms of platelet-mediated leukocyte recruitment during myocardial reperfusion. J Leukoc Biol 72(3):455-61. [PubMed: 12223512]  [MGI Ref ID J:124451]

Lam FW; Burns AR; Smith CW; Rumbaut RE. 2011. Platelets enhance neutrophil transendothelial migration via P-selectin glycoprotein ligand-1. Am J Physiol Heart Circ Physiol 300(2):H468-75. [PubMed: 21169400]  [MGI Ref ID J:169607]

Larbi KY; Dangerfield JP; Culley FJ; Marshall D; Haskard DO; Jose PJ; Williams TJ; Nourshargh S. 2003. P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses. J Leukoc Biol 73(1):65-73. [PubMed: 12525563]  [MGI Ref ID J:120684]

Laubli H; Stevenson JL; Varki A; Varki NM; Borsig L. 2006. L-selectin facilitation of metastasis involves temporal induction of Fut7-dependent ligands at sites of tumor cell arrest. Cancer Res 66(3):1536-42. [PubMed: 16452210]  [MGI Ref ID J:106671]

Lawson JA; Burns AR; Farhood A; Lynn Bajt M; Collins RG; Smith CW; Jaeschke H. 2000. Pathophysiologic importance of E- and L-selectin for neutrophil-induced liver injury during endotoxemia in mice. Hepatology 32(5):990-8. [PubMed: 11050049]  [MGI Ref ID J:106550]

Li Z; Burns AR; Han L; Rumbaut RE; Smith CW. 2011. IL-17 and VEGF Are Necessary for Efficient Corneal Nerve Regeneration. Am J Pathol 178(3):1106-16. [PubMed: 21356362]  [MGI Ref ID J:169522]

Li Z; Burns AR; Rumbaut RE; Smith CW. 2007. {gamma}{delta} T Cells Are Necessary for Platelet and Neutrophil Accumulation in Limbal Vessels and Efficient Epithelial Repair after Corneal Abrasion. Am J Pathol 171(3):838-845. [PubMed: 17675580]  [MGI Ref ID J:124350]

Li Z; Burns AR; Smith CW. 2006. Two waves of neutrophil emigration in response to corneal epithelial abrasion: distinct adhesion molecule requirements. Invest Ophthalmol Vis Sci 47(5):1947-55. [PubMed: 16639002]  [MGI Ref ID J:108504]

Li Z; Rumbaut RE; Burns AR; Smith CW. 2006. Platelet response to corneal abrasion is necessary for acute inflammation and efficient re-epithelialization. Invest Ophthalmol Vis Sci 47(11):4794-802. [PubMed: 17065490]  [MGI Ref ID J:123092]

Liu Z; Miner JJ; Yago T; Yao L; Lupu F; Xia L; McEver RP. 2010. Differential regulation of human and murine P-selectin expression and function in vivo. J Exp Med 207(13):2975-87. [PubMed: 21149548]  [MGI Ref ID J:176863]

Ludwig RJ; Bergmann P; Garbaraviciene J; von Stebut E; Radeke HH; Gille J; Diehl S; Hardt K; Henschler R; Kaufmann R; Pfeilschifter JM; Boehncke WH. 2010. Platelet, not endothelial, p-selectin expression contributes to generation of immunity in cutaneous contact hypersensitivity. Am J Pathol 176(3):1339-45. [PubMed: 20056837]  [MGI Ref ID J:158387]

Lukacs NW; John A; Berlin A; Bullard DC; Knibbs R; Stoolman LM. 2002. E- and P-selectins are essential for the development of cockroach allergen-induced airway responses. J Immunol 169(4):2120-5. [PubMed: 12165540]  [MGI Ref ID J:120695]

Manka D; Collins RG; Ley K; Beaudet AL; Sarembock IJ. 2001. Absence of p-selectin, but not intercellular adhesion molecule-1, attenuates neointimal growth after arterial injury in apolipoprotein e-deficient mice. Circulation 103(7):1000-5. [PubMed: 11181476]  [MGI Ref ID J:103301]

Maugeri N; Malato S; Femia EA; Pugliano M; Campana L; Lunghi F; Rovere-Querini P; Lussana F; Podda G; Cattaneo M; Ciceri F; Manfredi AA. 2011. Clearance of circulating activated platelets in polycythemia vera and essential thrombocythemia. Blood 118(12):3359-66. [PubMed: 21705500]  [MGI Ref ID J:176907]

Mizgerd JP; Bullard DC; Hicks MJ; Beaudet AL; Doerschuk CM. 1999. Chronic inflammatory disease alters adhesion molecule requirements for acute neutrophil emigration in mouse skin. J Immunol 162(9):5444-8. [PubMed: 10228023]  [MGI Ref ID J:112286]

Mori M; Salter JW; Vowinkel T; Krieglstein CF; Stokes KY; Granger DN. 2005. Molecular determinants of the prothrombogenic phenotype assumed by inflamed colonic venules. Am J Physiol Gastrointest Liver Physiol 288(5):G920-6. [PubMed: 15550557]  [MGI Ref ID J:98225]

Munoz FM; Hawkins EP; Bullard DC; Beaudet AL; Kaplan SL. 1997. Host defense against systemic infection with Streptococcus pneumoniae is impaired in E-, P-, and E-/P-selectin-deficient mice. J Clin Invest 100(8):2099-106. [PubMed: 9329976]  [MGI Ref ID J:101979]

Myers D Jr; Farris D; Hawley A; Wrobleski S; Chapman A; Stoolman L; Knibbs R; Strieter R; Wakefield T. 2002. Selectins influence thrombosis in a mouse model of experimental deep venous thrombosis. J Surg Res 108(2):212-21. [PubMed: 12505044]  [MGI Ref ID J:103110]

Nabors LK; Wang LD; Wagers AJ; Kansas GS. 2013. Overlapping roles for endothelial selectins in murine hematopoietic stem/progenitor cell homing to bone marrow. Exp Hematol 41(7):588-96. [PubMed: 23499761]  [MGI Ref ID J:214895]

Norman KE; Katopodis AG; Thoma G; Kolbinger F; Hicks AE; Cotter MJ; Pockley AG; Hellewell PG. 2000. P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo Blood 96(10):3585-91. [PubMed: 11071658]  [MGI Ref ID J:65810]

Osterholzer JJ; Ames T; Polak T; Sonstein J; Moore BB; Chensue SW; Toews GB; Curtis JL. 2005. CCR2 and CCR6, but not endothelial selectins, mediate the accumulation of immature dendritic cells within the lungs of mice in response to particulate antigen. J Immunol 175(2):874-83. [PubMed: 16002685]  [MGI Ref ID J:100694]

Papayannopoulou T; Priestley GV; Nakamoto B; Zafiropoulos V; Scott LM. 2001. Molecular pathways in bone marrow homing: dominant role of alpha(4)beta(1) over beta(2)-integrins and selectins. Blood 98(8):2403-11. [PubMed: 11588037]  [MGI Ref ID J:115624]

Patel KN; Soubra SH; Bellera RV; Dong JF; McMullen CA; Burns AR; Rumbaut RE. 2008. Differential role of von Willebrand factor and P-selectin on microvascular thrombosis in endotoxemia. Arterioscler Thromb Vasc Biol 28(12):2225-30. [PubMed: 18802014]  [MGI Ref ID J:159795]

Pelletier SD; Hong DS; Hu Y; Liu Y; Li S. 2004. Lack of the adhesion molecules P-selectin and intercellular adhesion molecule-1 accelerate the development of BCR/ABL-induced chronic myeloid leukemia-like myeloproliferative disease in mice. Blood 104(7):2163-71. [PubMed: 15213099]  [MGI Ref ID J:93772]

Perkowski S; Scherpereel A; Murciano JC; Arguiri E; Solomides CC; Albelda SM; Muzykantov V; Christofidou-Solomidou M. 2006. Dissociation between alveolar transmigration of neutrophils and lung injury in hyperoxia. Am J Physiol Lung Cell Mol Physiol 291(5):L1050-8. [PubMed: 16815892]  [MGI Ref ID J:144691]

Petri B; Broermann A; Li H; Khandoga AG; Zarbock A; Krombach F; Goerge T; Schneider SW; Jones C; Nieswandt B; Wild MK; Vestweber D. 2010. von Willebrand factor promotes leukocyte extravasation. Blood 116(22):4712-9. [PubMed: 20716766]  [MGI Ref ID J:166636]

Pierangeli SS; Espinola RG; Liu X; Harris EN. 2001. Thrombogenic effects of antiphospholipid antibodies are mediated by intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and P-selectin. Circ Res 88(2):245-50. [PubMed: 11157679]  [MGI Ref ID J:115602]

Puri KD; Doggett TA; Huang CY; Douangpanya J; Hayflick JS; Turner M; Penninger J; Diacovo TG. 2005. The role of endothelial PI3Kgamma activity in neutrophil trafficking. Blood 106(1):150-7. [PubMed: 15769890]  [MGI Ref ID J:107472]

Raisanen-Sokolowski A; Glysing-Jensen T; Russell ME. 1999. Donor and recipient contributions of ICAM-1 and P-selectin in parenchymal rejection and graft arteriosclerosis: insights from double knockout mice. J Heart Lung Transplant 18(8):735-43. [PubMed: 10512519]  [MGI Ref ID J:59743]

Ramos CL; Huo Y; Jung U; Ghosh S; Manka DR; Sarembock IJ; Ley K. 1999. Direct demonstration of P-selectin- and VCAM-1-dependent mononuclear cell rolling in early atherosclerotic lesions of apolipoprotein E-deficient mice. Circ Res 84(11):1237-44. [PubMed: 10364560]  [MGI Ref ID J:55953]

Ruth JH; Amin MA; Woods JM; He X; Samuel S; Yi N; Haas CS; Koch AE; Bullard DC. 2005. Accelerated development of arthritis in mice lacking endothelial selectins. Arthritis Res Ther 7(5):R959-70. [PubMed: 16207337]  [MGI Ref ID J:112848]

Scalia R; Armstead VE; Minchenko AG; Lefer AM. 1999. Essential role of P-selectin in the initiation of the inflammatory response induced by hemorrhage and reinfusion. J Exp Med 189(6):931-8. [PubMed: 10075976]  [MGI Ref ID J:110938]

Schneeberger EE; Vu Q; LeBlanc BW; Doerschuk CM. 2000. The accumulation of dendritic cells in the lung is impaired in CD18-/- but not in ICAM-1-/- mutant mice. J Immunol 164(5):2472-8. [PubMed: 10679084]  [MGI Ref ID J:60566]

Singbartl K; Green SA; Ley K. 2000. Blocking P-selectin protects from ischemia/reperfusion-induced acute renal failure. FASEB J 14(1):48-54. [PubMed: 10627279]  [MGI Ref ID J:118770]

Sligh JE Jr; Ballantyne CM; Rich SS; Hawkins HK; Smith CW; Bradley A; Beaudet AL. 1993. Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc Natl Acad Sci U S A 90(18):8529-33. [PubMed: 8104338]  [MGI Ref ID J:14565]

Sotnikov I; Veremeyko T; Starossom SC; Barteneva N; Weiner HL; Ponomarev ED. 2013. Platelets recognize brain-specific glycolipid structures, respond to neurovascular damage and promote neuroinflammation. PLoS One 8(3):e58979. [PubMed: 23555611]  [MGI Ref ID J:199888]

Staite ND; Justen JM; Sly LM; Beaudet AL; Bullard DC. 1996. Inhibition of delayed-type contact hypersensitivity in mice deficient in both E-selectin and P-selectin. Blood 88(8):2973-9. [PubMed: 8874194]  [MGI Ref ID J:36036]

Stark MA; Huo Y; Burcin TL; Morris MA; Olson TS; Ley K. 2005. Phagocytosis of Apoptotic Neutrophils Regulates Granulopoiesis via IL-23 and IL-17. Immunity 22(3):285-94. [PubMed: 15780986]  [MGI Ref ID J:97026]

Steinhoff U; Klemm U; Greiner M; Bordasch K; Kaufmann SH. 1998. Altered intestinal immune system but normal antibacterial resistance in the absence of P-selectin and ICAM-1. J Immunol 160(12):6112-20. [PubMed: 9637528]  [MGI Ref ID J:48760]

Sullivan C; Chen Y; Shan Y; Hu Y; Peng C; Zhang H; Kong L; Li S. 2011. Functional ramifications for the loss of P-selectin expression on hematopoietic and leukemic stem cells. PLoS One 6(10):e26246. [PubMed: 22039451]  [MGI Ref ID J:179748]

Sullivan VV; Hawley AE; Farris DM; Knipp BS; Varga AJ; Wrobleski SK; Thanapron P; Eagleton MJ; Myers DD; Fowlkes JB; Wakefield TW. 2003. Decrease in fibrin content of venous thrombi in selectin-deficient mice. J Surg Res 109(1):1-7. [PubMed: 12591228]  [MGI Ref ID J:119317]

Sun G; Chang WL; Li J; Berney SM; Kimpel D; van der Heyde HC. 2003. Inhibition of platelet adherence to brain microvasculature protects against severe Plasmodium berghei malaria. Infect Immun 71(11):6553-61. [PubMed: 14573677]  [MGI Ref ID J:86276]

Tu L; Poe JC; Kadono T; Venturi GM; Bullard DC; Tedder TF; Steeber DA. 2002. A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo. J Immunol 169(4):2034-43. [PubMed: 12165530]  [MGI Ref ID J:120206]

Underhill GH; Kolli KP; Kansas GS. 2003. Complexity within the plasma cell compartment of mice deficient in both E- and P-selectin: implications for plasma cell differentiation. Blood 102(12):4076-83. [PubMed: 12881311]  [MGI Ref ID J:115681]

Underhill GH; Minges-Wols HA; Fornek JL; Witte PL; Kansas GS. 2002. IgG plasma cells display a unique spectrum of leukocyte adhesion and homing molecules. Blood 99(8):2905-12. [PubMed: 11929781]  [MGI Ref ID J:76083]

Vandendries ER; Hamilton JR; Coughlin SR; Furie B; Furie BC. 2007. Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis. Proc Natl Acad Sci U S A 104(1):288-92. [PubMed: 17190826]  [MGI Ref ID J:118749]

Verdrengh M; Erlandsson-Harris H; Tarkowski A. 2000. Role of selectins in experimental Staphylococcus aureus-induced arthritis. Eur J Immunol 30(6):1606-13. [PubMed: 10898496]  [MGI Ref ID J:62704]

Wang HB; Wang JT; Zhang L; Geng ZH; Xu WL; Xu T; Huo Y; Zhu X; Plow EF; Chen M; Geng JG. 2007. P-selectin primes leukocyte integrin activation during inflammation. Nat Immunol 8(8):882-892. [PubMed: 17632516]  [MGI Ref ID J:123408]

Whalen MJ; Carlos TM; Dixon CE; Robichaud P; Clark RS; Marion DW; Kochanek PM. 2000. Reduced brain edema after traumatic brain injury in mice deficient in P-selectin and intercellular adhesion molecule-1. J Leukoc Biol 67(2):160-8. [PubMed: 10670575]  [MGI Ref ID J:119906]

Wingender G; Hiss M; Engel I; Peukert K; Ley K; Haller H; Kronenberg M; von Vietinghoff S. 2012. Neutrophilic granulocytes modulate invariant NKT cell function in mice and humans. J Immunol 188(7):3000-8. [PubMed: 22387552]  [MGI Ref ID J:183092]

Wood KC; Hebbel RP; Granger DN. 2004. Endothelial cell P-selectin mediates a proinflammatory and prothrombogenic phenotype in cerebral venules of sickle cell transgenic mice. Am J Physiol Heart Circ Physiol 286(5):H1608-14. [PubMed: 14704223]  [MGI Ref ID J:95603]

Xu Y; Huo Y; Toufektsian MC; Ramos SI; Ma Y; Tejani AD; French BA; Yang Z. 2006. Activated platelets contribute importantly to myocardial reperfusion injury. Am J Physiol Heart Circ Physiol 290(2):H692-9. [PubMed: 16199480]  [MGI Ref ID J:106723]

Yamazaki KG; Ihm SH; Thomas RL; Roth D; Villarreal F. 2012. Cell adhesion molecule mediation of myocardial inflammatory responses associated with ventricular pacing. Am J Physiol Heart Circ Physiol 302(7):H1387-93. [PubMed: 22268115]  [MGI Ref ID J:186585]

Yanaba K; Kaburagi Y; Takehara K; Steeber DA; Tedder TF; Sato S. 2003. Relative contributions of selectins and intercellular adhesion molecule-1 to tissue injury induced by immune complex deposition. Am J Pathol 162(5):1463-73. [PubMed: 12707029]  [MGI Ref ID J:113592]

Zanardo RC; Bonder CS; Hwang JM; Andonegui G; Liu L; Vestweber D; Zbytnuik L; Kubes P. 2004. A down-regulatable E-selectin ligand is functionally important for PSGL-1-independent leukocyte-endothelial cell interactions. Blood 104(12):3766-73. [PubMed: 15304396]  [MGI Ref ID J:94829]

Zaph C; Scott P. 2003. Th1 cell-mediated resistance to cutaneous infection with Leishmania major is independent of P- and E-selectins. J Immunol 171(9):4726-32. [PubMed: 14568948]  [MGI Ref ID J:107364]

Zarbock A; Lowell CA; Ley K. 2007. Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1. Immunity 26(6):773-83. [PubMed: 17543554]  [MGI Ref ID J:123587]

Zarbock A; Singbartl K; Ley K. 2006. Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. J Clin Invest 116(12):3211-9. [PubMed: 17143330]  [MGI Ref ID J:117354]

Health & husbandry

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Room Number           AX11

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

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Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $199.90Female or MaleHomozygous for Selptm1Bay  
Price per Pair (US dollars $)Pair Genotype
$399.80Homozygous for Selptm1Bay x Homozygous for Selptm1Bay  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $259.90Female or MaleHomozygous for Selptm1Bay  
Price per Pair (US dollars $)Pair Genotype
$519.80Homozygous for Selptm1Bay x Homozygous for Selptm1Bay  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.8)