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- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
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Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names 129-Gt(ROSA)26Sor (Changed: 15-DEC-04 ) 129/Sv-Gtrosa26 (Changed: 15-DEC-04 ) Type Congenic; Gene Trap; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Generation N?+2F10p (11-SEP-05)
Generation DefinitionsDonating Investigator Dr. Philippe Soriano, Mount Sinai School of Medicine Appearance
white-bellied agouti
Related Genotype: Aw/AwDescription
Mice heterozygous or homozygous for the ROSA26 retroviral insertion display no distinguishing phenotype. lacZ is expressed in all tissues of the developing embryo and in most tissues of the adult mouse. Formerly named TgR(ROSA26)26Sor.Development
This strain was developed in the laboratory of Dr. Philippe Soriano at the Fred Hutchinson Cancer Center, Seattle, WA. This mutant was made by a retroviral insertion of the beta-galactosidase gene (and accompanying splice acceptor and neo sequences) into ES cells. The construct was inserted in reverse orientation in the retroviral vector pGen-.
Control Information
| Control | ||
|---|---|---|
| See control note: | 129S1/SvImJ mice (Stock No. 002448) may be used as controls. This strain only provides an approximate match to this 129 strain. | |
| Wild-type from the colony | ||
| 002448 129S1/SvImJ | (approximate) | |
| Considerations for Choosing Controls | ||
Related Strains
lacZ Expression Strains
View lacZ Expression Strains (255 strains)
002192 B6.129S7-Gt(ROSA)26Sor/J 002073 B6;129S-Gt(ROSA)26Sor/J 002955 C.129S7-Gt(ROSA)26Sor/J 005420 C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/GrsrJ
Additional Web Information
Fluorescent Proteins/lacZ Systems
New 129 Nomenclature Bulletin
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Research Tools
lacZ Expression
Developmental Biology Research
Genetics Research
Tissue/Cell Markers
Tissue/Cell Markers: transplantation marker for embryonic and adult tissue
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Gt(ROSA)26Sor | ||
|---|---|---|---|
| Allele Name | gene trap ROSA 26, Philippe Soriano | ||
| Allele Type | Gene trapped | ||
| Common Name(s) | R26tg; R26R3; ROSA26; ROSA26-lacZ; Rosa26lacZ; TgR(ROSA26)26Sor; gtrosa26; | ||
| Mutation Made By | Dr. Philippe Soriano, Mount Sinai School of Medicine | ||
| Strain of Origin | 129S7/SvEvBrd-Hprt<+> | ||
| ES Cell Line Name | AB1 | ||
| ES Cell Line Strain | 129S7/SvEvBrd-Hprt<+> | ||
| Site of Expression | All tissues of the developing embryo and in most tissues of the adult mouse. | ||
| Expressed Gene | lacZ, beta-galactosidase, E. coli | ||
| General Note | ES cell line = AB1 or AB2.1. No overt phenotypes in heterozygous or homozygous animals. The trapped gene appears to be ubiquitously expressed during embryonic development and in all hematopoietic cells. | ||
| Molecular Note | Random insertion of retroviral gene trap vector ROSA, Reverse Orientation with Splice Acceptor, which contains the beta-galactosidase gene and accompanying splice acceptor and neo sequences. The construct was inserted in reverse orientation in the retroviral vector pGen-. The transgene is controlled by an unknown endogenous promoter. lacZ is expressed in all tissues of the developing embryo and in most tissues of the adult transgenic mouse. [MGI Ref ID J:39814] [MGI Ref ID J:79478] | ||
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | AV258896; Gtrgeo26; Gtrosa26; R26; ROSA26; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Gt(ROSA)26Sor MCA,Separated MCA
Gt(ROSA)26Sor MCA, Melt Curve Analysis
Gt(ROSA)26Sor STD, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Friedrich G; Soriano P. 1991. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev 5(9):1513-23. [PubMed: 1653172] [MGI Ref ID J:79478]
Additional References
Jacobsen CM; Narita N; Bielinska M; Syder AJ; Gordon JI; Wilson DB. 2002. Genetic mosaic analysis reveals that GATA-4 is required for proper differentiation of mouse gastric epithelium. Dev Biol 241(1):34-46. [PubMed: 11784093] [MGI Ref ID J:73717]
Sequeira Lopez ML; Pentz ES; Robert B; Abrahamson DR; Gomez RA. 2001. Embryonic origin and lineage of juxtaglomerular cells. Am J Physiol Renal Physiol 281(2):F345-56. [PubMed: 11457727] [MGI Ref ID J:70875]
Yang Z; Ding K; Pan L; Deng M; Gan L. 2003. Math5 determines the competence state of retinal ganglion cell progenitors. Dev Biol 264(1):240-54. [PubMed: 14623245] [MGI Ref ID J:86669]
Zambrowicz BP; Imamoto A; Fiering S; Herzenberg LA; Kerr WG; Soriano P. 1997. Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. Proc Natl Acad Sci U S A 94(8):3789-94. [PubMed: 9108056] [MGI Ref ID J:39814]
Gt(ROSA)26Sor relatedAghi M; Cohen KS; Klein RJ; Scadden DT; Chiocca EA. 2006. Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Res 66(18):9054-64. [PubMed: 16982747] [MGI Ref ID J:112935]
Ahn GO; Brown JM. 2008. Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells. Cancer Cell 13(3):193-205. [PubMed: 18328424] [MGI Ref ID J:132946]
Ando S; Abe R; Sasaki M; Murata J; Inokuma D; Shimizu H. 2009. Bone marrow-derived cells are not the origin of the cancer stem cells in ultraviolet-induced skin cancer. Am J Pathol 174(2):595-601. [PubMed: 19131588] [MGI Ref ID J:144196]
Anthony TE; Klein C; Fishell G; Heintz N. 2004. Radial glia serve as neuronal progenitors in all regions of the central nervous system. Neuron 41(6):881-90. [PubMed: 15046721] [MGI Ref ID J:89775]
Arnold K; Sarkar A; Yram MA; Polo JM; Bronson R; Sengupta S; Seandel M; Geijsen N; Hochedlinger K. 2011. Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell 9(4):317-29. [PubMed: 21982232] [MGI Ref ID J:177655]
Arnold SJ; Hofmann UK; Bikoff EK; Robertson EJ. 2008. Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. Development 135(3):501-11. [PubMed: 18171685] [MGI Ref ID J:131055]
Arruda-Carvalho M; Sakaguchi M; Akers KG; Josselyn SA; Frankland PW. 2011. Posttraining ablation of adult-generated neurons degrades previously acquired memories. J Neurosci 31(42):15113-27. [PubMed: 22016545] [MGI Ref ID J:177636]
Baba M; Furihata M; Hong SB; Tessarollo L; Haines DC; Southon E; Patel V; Igarashi P; Alvord WG; Leighty R; Yao M; Bernardo M; Ileva L; Choyke P; Warren MB; Zbar B; Linehan WM; Schmidt LS. 2008. Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys. J Natl Cancer Inst 100(2):140-54. [PubMed: 18182616] [MGI Ref ID J:130978]
Babaev VR; Yancey PG; Ryzhov SV; Kon V; Breyer MD; Magnuson MA; Fazio S; Linton MF. 2005. Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 25(8):1647-53. [PubMed: 15947238] [MGI Ref ID J:114332]
Bianco C; Cotten C; Lonardo E; Strizzi L; Baraty C; Mancino M; Gonzales M; Watanabe K; Nagaoka T; Berry C; Arai AE; Minchiotti G; Salomon DS. 2009. Cripto-1 is required for hypoxia to induce cardiac differentiation of mouse embryonic stem cells. Am J Pathol 175(5):2146-58. [PubMed: 19834060] [MGI Ref ID J:154688]
Bosman EA; Lawson KA; Debruyn J; Beek L; Francis A; Schoonjans L; Huylebroeck D; Zwijsen A. 2006. Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels. Development 133(17):3399-409. [PubMed: 16887830] [MGI Ref ID J:112229]
Boyer A; Yeh JR; Zhang X; Paquet M; Gaudin A; Nagano MC; Boerboom D. 2012. CTNNB1 signaling in sertoli cells downregulates spermatogonial stem cell activity via WNT4. PLoS One 7(1):e29764. [PubMed: 22253774] [MGI Ref ID J:184318]
Chappuis V; Gamer L; Cox K; Lowery JW; Bosshardt DD; Rosen V. 2012. Periosteal BMP2 activity drives bone graft healing. Bone 51(4):800-9. [PubMed: 22846673] [MGI Ref ID J:193357]
Chen D; Jarrell A; Guo C; Lang R; Atit R. 2012. Dermal beta-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation. Development 139(8):1522-33. [PubMed: 22434869] [MGI Ref ID J:183485]
Chi L; Itaranta P; Zhang S; Vainio S. 2006. Sprouty2 is involved in male sex organogenesis by controlling fibroblast growth factor 9-induced mesonephric cell migration to the developing testis. Endocrinology 147(8):3777-88. [PubMed: 16675530] [MGI Ref ID J:129651]
Choi J; Curtis SJ; Roy DM; Flesken-Nikitin A; Nikitin AY. 2010. Local mesenchymal stem/progenitor cells are a preferential target for initiation of adult soft tissue sarcomas associated with p53 and Rb deficiency. Am J Pathol 177(5):2645-58. [PubMed: 20864684] [MGI Ref ID J:166254]
Ciarloni L; Mallepell S; Brisken C. 2007. Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development. Proc Natl Acad Sci U S A 104(13):5455-60. [PubMed: 17369357] [MGI Ref ID J:120116]
Costello I; Pimeisl IM; Drager S; Bikoff EK; Robertson EJ; Arnold SJ. 2011. The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation. Nat Cell Biol 13(9):1084-91. [PubMed: 21822279] [MGI Ref ID J:176969]
Croyle MJ; Lehman JM; O'Connor AK; Wong SY; Malarkey EB; Iribarne D; Dowdle WE; Schoeb TR; Verney ZM; Athar M; Michaud EJ; Reiter JF; Yoder BK. 2011. Role of epidermal primary cilia in the homeostasis of skin and hair follicles. Development 138(9):1675-85. [PubMed: 21429982] [MGI Ref ID J:171221]
Cuttler AS; Leclair RJ; Stohn JP; Wang Q; Sorenson CM; Liaw L; Lindner V. 2011. Characterization of Pdgfrb-Cre transgenic mice reveals reduction of ROSA26 reporter activity in remodeling arteries. Genesis 49(8):673-80. [PubMed: 21557454] [MGI Ref ID J:175492]
Dietrich MO; Bober J; Ferreira JG; Tellez LA; Mineur YS; Souza DO; Gao XB; Picciotto MR; Araujo I; Liu ZW; Horvath TL. 2012. AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors. Nat Neurosci 15(8):1108-10. [PubMed: 22729177] [MGI Ref ID J:191603]
Duncan AW; Hickey RD; Paulk NK; Culberson AJ; Olson SB; Finegold MJ; Grompe M. 2009. Ploidy reductions in murine fusion-derived hepatocytes. PLoS Genet 5(2):e1000385. [PubMed: 19229314] [MGI Ref ID J:146785]
Follenzi A; Raut S; Merlin S; Sarkar R; Gupta S. 2012. Role of bone marrow transplantation for correcting hemophilia A in mice. Blood 119(23):5532-42. [PubMed: 22368271] [MGI Ref ID J:186576]
Fraidenraich D; Stillwell E; Romero E; Wilkes D; Manova K; Basson CT; Benezra R. 2004. Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells. Science 306(5694):247-52. [PubMed: 15472070] [MGI Ref ID J:93083]
Haara O; Fujimori S; Schmidt-Ullrich R; Hartmann C; Thesleff I; Mikkola ML. 2011. Ectodysplasin and Wnt pathways are required for salivary gland branching morphogenesis. Development 138(13):2681-91. [PubMed: 21652647] [MGI Ref ID J:173573]
Hadland BK; Huppert SS; Kanungo J; Xue Y; Jiang R; Gridley T; Conlon RA; Cheng AM; Kopan R; Longmore GD. 2004. A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood 104(10):3097-105. [PubMed: 15251982] [MGI Ref ID J:94898]
Hirai H; Verma M; Watanabe S; Tastad C; Asakura Y; Asakura A. 2010. MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3. J Cell Biol 191(2):347-65. [PubMed: 20956382] [MGI Ref ID J:165481]
Ho KJ; Bass CE; Kroemer AH; Ma C; Terwilliger E; Karp SJ. 2008. Optimized adeno-associated virus 8 produces hepatocyte-specific Cre-mediated recombination without toxicity or affecting liver regeneration. Am J Physiol Gastrointest Liver Physiol 295(2):G412-9. [PubMed: 18535290] [MGI Ref ID J:138633]
Hoshino M; Nakamura S; Mori K; Kawauchi T; Terao M; Nishimura YV; Fukuda A; Fuse T; Matsuo N; Sone M; Watanabe M; Bito H; Terashima T; Wright CV; Kawaguchi Y; Nakao K; Nabeshima Y. 2005. Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. Neuron 47(2):201-13. [PubMed: 16039563] [MGI Ref ID J:100997]
Humphreys BD; Lin SL; Kobayashi A; Hudson TE; Nowlin BT; Bonventre JV; Valerius MT; McMahon AP; Duffield JS. 2010. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 176(1):85-97. [PubMed: 20008127] [MGI Ref ID J:158051]
Iwata H; Manabe I; Fujiu K; Yamamoto T; Takeda N; Eguchi K; Furuya A; Kuro-o M; Sata M; Nagai R. 2010. Bone marrow-derived cells contribute to vascular inflammation but do not differentiate into smooth muscle cell lineages. Circulation 122(20):2048-57. [PubMed: 21041690] [MGI Ref ID J:179478]
Jager R; Maurer J; Jacob A; Schorle H. 2004. Cell type-specific conditional regulation of the c-myc proto-oncogene by combining Cre/loxP recombination and tamoxifen-mediated activation. Genesis 38(3):145-50. [PubMed: 15048812] [MGI Ref ID J:89756]
Kitajima S; Takagi A; Inoue T; Saga Y. 2000. MesP1 and MesP2 are essential for the development of cardiac mesoderm. Development 127(15):3215-26. [PubMed: 10887078] [MGI Ref ID J:62984]
Kleaveland B; Zheng X; Liu JJ; Blum Y; Tung JJ; Zou Z; Chen M; Guo L; Lu MM; Zhou D; Kitajewski J; Affolter M; Ginsberg MH; Kahn ML. 2009. Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med 15(2):169-76. [PubMed: 19151727] [MGI Ref ID J:146528]
Kobayashi A; Valerius MT; Mugford JW; Carroll TJ; Self M; Oliver G; McMahon AP. 2008. Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell 3(2):169-81. [PubMed: 18682239] [MGI Ref ID J:148455]
Kohlhepp RL; Hegge LF; Moser AR. 2001. The ROSA26 LacZ-neoR insertion confers resistance to mammary tumors in ApcMin/+ mice. Mamm Genome 12(8):606-11. [PubMed: 11471054] [MGI Ref ID J:70825]
Kohlhepp RL; Hegge LF; Nett JE; Moser AR. 2000. ROSA26 mice carry a modifier of Min-induced mammary and intestinal tumor development. Mamm Genome 11(12):1058-62. [PubMed: 11130972] [MGI Ref ID J:66060]
Kubota H; Avarbock MR; Schmidt JA; Brinster RL. 2009. Spermatogonial stem cells derived from infertile Wv/Wv mice self-renew in vitro and generate progeny following transplantation. Biol Reprod 81(2):293-301. [PubMed: 19369648] [MGI Ref ID J:152976]
Li L; Garikepati RM; Tsukerman S; Kohan D; Wade JB; Tiwari S; Ecelbarger CM. 2013. Reduced ENaC activity and blood pressure in mice with genetic knockout of the insulin receptor in the renal collecting duct. Am J Physiol Renal Physiol 304(3):F279-88. [PubMed: 23195676] [MGI Ref ID J:192571]
Li Z; Chen MJ; Stacy T; Speck NA. 2006. Runx1 function in hematopoiesis is required in cells that express Tek. Blood 107(1):106-10. [PubMed: 16174759] [MGI Ref ID J:125796]
Liu HX; Komatsu Y; Mishina Y; Mistretta CM. 2012. Neural crest contribution to lingual mesenchyme, epithelium and developing taste papillae and taste buds. Dev Biol 368(2):294-303. [PubMed: 22659543] [MGI Ref ID J:186559]
Lugus JJ; Park C; Ma YD; Choi K. 2009. Both primitive and definitive blood cells are derived from Flk-1+ mesoderm. Blood 113(3):563-6. [PubMed: 18957687] [MGI Ref ID J:144056]
Matt N; Dupe V; Garnier JM; Dennefeld C; Chambon P; Mark M; Ghyselinck NB. 2005. Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells. Development 132(21):4789-800. [PubMed: 16207763] [MGI Ref ID J:102847]
Medina-Martinez O; Amaya-Manzanares F; Liu C; Mendoza M; Shah R; Zhang L; Behringer RR; Mahon KA; Jamrich M. 2009. Cell-autonomous requirement for rx function in the mammalian retina and posterior pituitary. PLoS ONE 4(2):e4513. [PubMed: 19229337] [MGI Ref ID J:146279]
Montgomery RK; Carlone DL; Richmond CA; Farilla L; Kranendonk ME; Henderson DE; Baffour-Awuah NY; Ambruzs DM; Fogli LK; Algra S; Breault DT. 2011. Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci U S A 108(1):179-84. [PubMed: 21173232] [MGI Ref ID J:169012]
Morroni M; Giordano A; Zingaretti MC; Boiani R; De Matteis R; Kahn BB; Nisoli E; Tonello C; Pisoschi C; Luchetti MM; Marelli M; Cinti S. 2004. Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland. Proc Natl Acad Sci U S A 101(48):16801-6. [PubMed: 15556998] [MGI Ref ID J:94729]
Mukouyama YS; Deneen B; Lukaszewicz A; Novitch BG; Wichterle H; Jessell TM; Anderson DJ. 2006. Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo. Proc Natl Acad Sci U S A 103(5):1551-6. [PubMed: 16432183] [MGI Ref ID J:142333]
Nguyen QT; Son YJ; Sanes JR; Lichtman JW. 2000. Nerve terminals form but fail to mature when postsynaptic differentiation is blocked: in vivo analysis using mammalian nerve-muscle chimeras. J Neurosci 20(16):6077-86. [PubMed: 10934257] [MGI Ref ID J:120388]
Nishimura EK; Jordan SA; Oshima H; Yoshida H; Osawa M; Moriyama M; Jackson IJ; Barrandon Y; Miyachi Y; Nishikawa S. 2002. Dominant role of the niche in melanocyte stem-cell fate determination. Nature 416(6883):854-60. [PubMed: 11976685] [MGI Ref ID J:130556]
Niu Z; Goodyear SM; Rao S; Wu X; Tobias JW; Avarbock MR; Brinster RL. 2011. MicroRNA-21 regulates the self-renewal of mouse spermatogonial stem cells. Proc Natl Acad Sci U S A 108(31):12740-5. [PubMed: 21768389] [MGI Ref ID J:176016]
Oatley MJ; Kaucher AV; Racicot KE; Oatley JM. 2011. Inhibitor of DNA binding 4 is expressed selectively by single spermatogonia in the male germline and regulates the self-renewal of spermatogonial stem cells in mice. Biol Reprod 85(2):347-56. [PubMed: 21543770] [MGI Ref ID J:175284]
Parisi T; Bronson RT; Lees JA. 2009. Inhibition of pituitary tumors in Rb mutant chimeras through E2f4 loss reveals a key suppressive role for the pRB/E2F pathway in urothelium and ganglionic carcinogenesis. Oncogene 28(4):500-8. [PubMed: 18997819] [MGI Ref ID J:145896]
Patel V; Li L; Cobo-Stark P; Shao X; Somlo S; Lin F; Igarashi P. 2008. Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia. Hum Mol Genet 17(11):1578-90. [PubMed: 18263895] [MGI Ref ID J:135523]
Pennimpede T; Proske J; Konig A; Vidigal JA; Morkel M; Bramsen JB; Herrmann BG; Wittler L. 2012. In vivo knockdown of Brachyury results in skeletal defects and urorectal malformations resembling caudal regression syndrome. Dev Biol 372(1):55-67. [PubMed: 22995555] [MGI Ref ID J:190628]
Que J; Wilm B; Hasegawa H; Wang F; Bader D; Hogan BL. 2008. Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development. Proc Natl Acad Sci U S A 105(43):16626-30. [PubMed: 18922767] [MGI Ref ID J:143278]
R R; Speed R; Taggart M; Cooke HJ. 2003. Spermatogenesis in testes of Dazl null mice after transplantation of wild-type germ cells. Reproduction 126(5):599-604. [PubMed: 14611632] [MGI Ref ID J:87151]
Robinson ML; Ohtaka-Maruyama C; Chan CC; Jamieson S; Dickson C; Overbeek PA; Chepelinsky AB. 1998. Disregulation of ocular morphogenesis by lens-specific expression of FGF-3/int-2 in transgenic mice. Dev Biol 198(1):13-31. [PubMed: 9640329] [MGI Ref ID J:174265]
Rosengauer E; Hartwich H; Hartmann AM; Rudnicki A; Satheesh SV; Avraham KB; Nothwang HG. 2012. Egr2::cre mediated conditional ablation of dicer disrupts histogenesis of Mammalian central auditory nuclei. PLoS One 7(11):e49503. [PubMed: 23152916] [MGI Ref ID J:194793]
Samokhvalov IM; Samokhvalova NI; Nishikawa S. 2007. Cell tracing shows the contribution of the yolk sac to adult haematopoiesis. Nature 446(7139):1056-61. [PubMed: 17377529] [MGI Ref ID J:121435]
Seandel M; James D; Shmelkov SV; Falciatori I; Kim J; Chavala S; Scherr DS; Zhang F; Torres R; Gale NW; Yancopoulos GD; Murphy A; Valenzuela DM; Hobbs RM; Pandolfi PP; Rafii S. 2007. Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature 449(7160):346-50. [PubMed: 17882221] [MGI Ref ID J:126330]
Sebzda E; Hibbard C; Sweeney S; Abtahian F; Bezman N; Clemens G; Maltzman JS; Cheng L; Liu F; Turner M; Tybulewicz V; Koretzky GA; Kahn ML. 2006. Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development. Dev Cell 11(3):349-61. [PubMed: 16950126] [MGI Ref ID J:112805]
Shi Y; Desponts C; Do JT; Hahm HS; Scholer HR; Ding S. 2008. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 3(5):568-74. [PubMed: 18983970] [MGI Ref ID J:149867]
Shibata M; Garcia-Garcia MJ. 2011. The mouse KRAB zinc-finger protein CHATO is required in embryonic-derived tissues to control yolk sac and placenta morphogenesis. Dev Biol 349(2):331-41. [PubMed: 21094155] [MGI Ref ID J:168015]
Soriano P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain [letter] Nat Genet 21(1):70-1. [PubMed: 9916792] [MGI Ref ID J:64292]
Takahashi Y; Kitajima S; Inoue T; Kanno J; Saga Y. 2005. Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostro-caudal patterning of somites. Development 132(4):787-96. [PubMed: 15677726] [MGI Ref ID J:120635]
Tanaka KK; Hall JK; Troy AA; Cornelison DD; Majka SM; Olwin BB. 2009. Syndecan-4-expressing muscle progenitor cells in the SP engraft as satellite cells during muscle regeneration. Cell Stem Cell 4(3):217-25. [PubMed: 19265661] [MGI Ref ID J:149919]
Turlo KA; Noel OD; Vora R; LaRussa M; Fassler R; Hall-Glenn F; Iruela-Arispe ML. 2012. An essential requirement for beta1 integrin in the assembly of extracellular matrix proteins within the vascular wall. Dev Biol 365(1):23-35. [PubMed: 22331032] [MGI Ref ID J:184940]
Veikkolainen V; Naillat F; Railo A; Chi L; Manninen A; Hohenstein P; Hastie N; Vainio S; Elenius K. 2012. ErbB4 Modulates Tubular Cell Polarity and Lumen Diameter during Kidney Development. J Am Soc Nephrol 23(1):112-22. [PubMed: 22076439] [MGI Ref ID J:180153]
Verma M; Asakura A. 2011. Efficient single muscle fiber isolation from alcohol-fixed adult muscle following beta-galactosidase staining for satellite cell detection. J Histochem Cytochem 59(1):60-7. [PubMed: 20876523] [MGI Ref ID J:170193]
Vidal A; Zacharoulis S; Guo W; Shaffer D; Giancotti F; Bramley AH; de la Hoz C; Jensen KK; Kato D; MacDonald DD; Knowles J; Yeh N; Frohman LA; Rafii S; Lyden D; Koff A. 2005. p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow. Proc Natl Acad Sci U S A 102(19):6890-5. [PubMed: 15867156] [MGI Ref ID J:99064]
Wijgerde M; McMahon JA; Rule M; McMahon AP. 2002. A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev 16(22):2849-64. [PubMed: 12435628] [MGI Ref ID J:80206]
Woo WM; Zhen HH; Oro AE. 2012. Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop. Genes Dev 26(11):1235-46. [PubMed: 22661232] [MGI Ref ID J:184827]
Yamamoto Y; Watanabe T; Hoki Y; Shirane K; Li Y; Ichiiyanagi K; Kuramochi-Miyagawa S; Toyoda A; Fujiyama A; Oginuma M; Suzuki H; Sado T; Nakano T; Sasaki H. 2013. Targeted gene silencing in mouse germ cells by insertion of a homologous DNA into a piRNA generating locus. Genome Res 23(2):292-9. [PubMed: 23132912] [MGI Ref ID J:192826]
Yang QE; Racicot KE; Kaucher AV; Oatley MJ; Oatley JM. 2013. MicroRNAs 221 and 222 regulate the undifferentiated state in mammalian male germ cells. Development 140(2):280-90. [PubMed: 23221369] [MGI Ref ID J:191051]
Ybot-Gonzalez P; Savery D; Gerrelli D; Signore M; Mitchell CE; Faux CH; Greene ND; Copp AJ. 2007. Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development 134(4):789-99. [PubMed: 17229766] [MGI Ref ID J:119920]
Yeh JR; Zhang X; Nagano MC. 2012. Indirect effects of Wnt3a/beta-catenin signalling support mouse spermatogonial stem cells in vitro. PLoS One 7(6):e40002. [PubMed: 22761943] [MGI Ref ID J:187913]
Yeh JR; Zhang X; Nagano MC. 2011. Wnt5a is a cell-extrinsic factor that supports self-renewal of mouse spermatogonial stem cells. J Cell Sci 124(Pt 14):2357-66. [PubMed: 21693582] [MGI Ref ID J:183043]
Zambrowicz BP; Imamoto A; Fiering S; Herzenberg LA; Kerr WG; Soriano P. 1997. Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. Proc Natl Acad Sci U S A 94(8):3789-94. [PubMed: 9108056] [MGI Ref ID J:39814]
Zhang C; Wu B; Beglopoulos V; Wines-Samuelson M; Zhang D; Dragatsis I; Sudhof TC; Shen J. 2009. Presenilins are essential for regulating neurotransmitter release. Nature 460(7255):632-6. [PubMed: 19641596] [MGI Ref ID J:150936]
Zhang QS; Eaton L; Snyder ER; Houghtaling S; Mitchell JB; Finegold M; Van Waes C; Grompe M. 2008. Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice. Cancer Res 68(5):1601-8. [PubMed: 18316625] [MGI Ref ID J:132758]
Zhang QS; Marquez-Loza L; Eaton L; Duncan AW; Goldman DC; Anur P; Watanabe-Smith K; Rathbun RK; Fleming WH; Bagby GC; Grompe M. 2010. Fancd2-/- mice have hematopoietic defects that can be partially corrected by resveratrol. Blood 116(24):5140-8. [PubMed: 20826722] [MGI Ref ID J:167414]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.Colony Maintenance
Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2250.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2925.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| See control note: | 129S1/SvImJ mice (Stock No. 002448) may be used as controls. This strain only provides an approximate match to this 129 strain. | |
| Wild-type from the colony | ||
| 002448 129S1/SvImJ | (approximate) | |
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.