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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Mutant Strain; Transgenic; Additional information on Genetically Engineered Mutant Mice. Mating System F1 x Hemizygote (Female x Male) Species laboratory mouse Generation N?+N6 (30-SEP-08) Donating Investigator Mark Gurney, deCode Genetics Appearance
multiple coat colors
Related Genotype: segregating for a, A, Oca2p, Tyrc and Pde6brd1Description
This transgenic strain carries the normal allele of the human SOD1 gene. Originally published as N1029, it has been reported that the SOD1 protein level is the same as in the transgenic strain carrying the SOD1*G93A transgene (002726), even though the copy number in the SOD1*G93A transgenic is higher. This strain serves as a control for the B6SJL-Tg(SOD1*G93A)1Gur/J (002726) and the B6SJL-Tg(SOD1*G93A)dl1Gur/J (002300) strains.
Control Information
| Control | ||
|---|---|---|
| Noncarrier female | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(SOD1)2Gur allele
002298 B6.Cg-Tg(SOD1)2Gur/J View Strains carrying Tg(SOD1)2Gur (1 strain)
008342 B6.Cg-Tg(SOD1*G37R)42Dpr/J 008248 B6.Cg-Tg(SOD1*G85R)148Dwc/J 004435 B6.Cg-Tg(SOD1*G93A)1Gur/J 002299 B6.Cg-Tg(SOD1*G93A)dl1Gur/J 002726 B6SJL-Tg(SOD1*G93A)1Gur/J 002300 B6SJL-Tg(SOD1*G93A)dl1Gur/J 002628 C57BL/6-Tg(SOD1)10Cje/J 002629 C57BL/6-Tg(SOD1)3Cje/J 008230 FVB(Cg)-Tg(Thy1-SOD1*G93A)T3Hgrd/J
Phenotype
Phenotype Information
assigned by genotype
Tg(SOD1)2Gur/0
involves: C57BL/6 * SJL
- nervous system phenotype
- abnormal spinal cord morphology (MGI Ref ID J:76718)
- develop neurofilament-rich spheroids in the spinal cords at much later time (132 days of age) points than Tg(SOD1-G93A)1Gur mutants, however do not appear to develop motor neuron disease
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tg(SOD1)2Gur/0
involves: C57BL/6 * CBA * SJL
- nervous system phenotype
- abnormal oligodendrocyte morphology (MGI Ref ID J:134095)
- ubiquinated SOD1 aggregates accumulate in oligodendrocytes of spinal cords of aged mice (>70 weeks) but a much lower density than in double transgenic T3/SOD1 animals
This mouse can be used to support research in many areas including:
Metabolism Research
Mouse/Human Gene Homologs
amyotrophic lateral sclerosis (ALS)
Neurobiology Research
Amyotrophic Lateral Sclerosis (ALS)
Metabolic Defects
Neurodegeneration
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(SOD1)2Gur | ||
|---|---|---|---|
| Allele Name | transgene insertion 2, Mark E Gurney | ||
| Allele Type | Transgenic (random, expressed) | ||
| Common Name(s) | N1029; N29; WT SOD1; tg-SOD1; | ||
| Mutation Made By | Mark Gurney, deCode Genetics | ||
| Strain of Origin | (C57BL/6 x SJL)F1 | ||
| Expressed Gene | SOD1, superoxide dismutase 1, soluble, human | ||
| Promoter | SOD1, superoxide dismutase 1, soluble, human | ||
| General Note | Expression level of the wild-type transgene in transgenic animals is comparable to that in transgenic mice carrying the original highest expressing line Tg(SOD1*G93A)2Gur. | ||
| Molecular Note | The transgene contains the normal allele of the human superoxide dismutase 1 gene (SOD1). Transgene expression in brain was confirmed by enzyme immunoassay using antibodies that recognize human SOD1 protein. [MGI Ref ID J:32665] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(SOD), MCA, vers. 2
Tg(SOD1), STD PCR, vers. 1
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Gurney ME; Pu H; Chiu AY; Dal Canto MC; Polchow CY; Alexander DD; Caliendo J; Hentati A; Kwon YW; Deng HX; Chen W; Zhai P; Sufit RL; Siddique T. 1994. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation [see comments] [published erratum appears in Science 1995 Jul 14;269(5221):149] Science 264(5166):1772-5. [PubMed: 8209258] [MGI Ref ID J:32665]
Additional References
Chiu AY; Zhai P; Dal Canto MC; Peters TM; Kwon YW; Prattis SM; Gurney ME. 1995. Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis. Mol Cell Neurosci 6(4):349-62. [PubMed: 8846004] [MGI Ref ID J:80625]
Giess R; Holtmann B; Braga M; Grimm T; Muller-Myhsok B; Toyka KV; Sendtner M. 2002. Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: potential impact of CNTF as a candidate modifier gene. Am J Hum Genet 70(5):1277-86. [PubMed: 11951178] [MGI Ref ID J:76257]
Kabashi E; Agar JN; Taylor DM; Minotti S; Durham HD. 2004. Focal dysfunction of the proteasome: a pathogenic factor in a mouse model of amyotrophic lateral sclerosis. J Neurochem 89(6):1325-35. [PubMed: 15189335] [MGI Ref ID J:92215]
Kilic E; Weishaupt JH; Kilic U; Rohde G; Yulug B; Peters K; Hermann DM; Bahr M. 2004. The superoxide dismutase1 (sod1) G93A mutation does not promote neuronal injury after focal brain ischemia and optic nerve transection in mice. Neuroscience 128(2):359-64. [PubMed: 15350647] [MGI Ref ID J:92468]
Kruidenier L; van Meeteren ME; Kuiper I; Jaarsma D; Lamers CB; Zijlstra FJ; Verspaget HW. 2003. Attenuated mild colonic inflammation and improved survival from severe DSS-colitis of transgenic Cu/Zn-SOD mice. Free Radic Biol Med 34(6):753-65. [PubMed: 12633752] [MGI Ref ID J:82695]
Tu PH; Raju P; Robinson KA; Gurney ME; Trojanowski JQ; Lee VM. 1996. Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions. Proc Natl Acad Sci U S A 93(7):3155-60. [PubMed: 8610185] [MGI Ref ID J:76718]
Tg(SOD1)2Gur relatedAlexianu ME; Kozovska M; Appel SH. 2001. Immune reactivity in a mouse model of familial ALS correlates with disease progression. Neurology 57(7):1282-9. [PubMed: 11591849] [MGI Ref ID J:78936]
Almer G; Vukosavic S; Romero N; Przedborski S. 1999. Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem 72(6):2415-25. [PubMed: 10349851] [MGI Ref ID J:55026]
Ammassari-Teule M; Restivo L; Pietteur V; Passino E. 2001. Learning about the context in genetically-defined mice. Behav Brain Res 125(1-2):195-204. [PubMed: 11682111] [MGI Ref ID J:92773]
Basso M; Massignan T; Samengo G; Cheroni C; De Biasi S; Salmona M; Bendotti C; Bonetto V. 2006. Insoluble mutant SOD1 is partly oligoubiquitinated in amyotrophic lateral sclerosis mice. J Biol Chem 281(44):33325-35. [PubMed: 16943203] [MGI Ref ID J:117191]
Boston-Howes W; Gibb SL; Williams EO; Pasinelli P; Brown RH Jr; Trotti D. 2006. Caspase-3 cleaves and inactivates the glutamate transporter EAAT2. J Biol Chem 281(20):14076-84. [PubMed: 16567804] [MGI Ref ID J:113480]
Bucher S; Braunstein KE; Niessen HG; Kaulisch T; Neumaier M; Boeckers TM; Stiller D; Ludolph AC. 2007. Vacuolization correlates with spin-spin relaxation time in motor brainstem nuclei and behavioural tests in the transgenic G93A-SOD1 mouse model of ALS. Eur J Neurosci 26(7):1895-901. [PubMed: 17868365] [MGI Ref ID J:127265]
Chiu AY; Zhai P; Dal Canto MC; Peters TM; Kwon YW; Prattis SM; Gurney ME. 1995. Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis. Mol Cell Neurosci 6(4):349-62. [PubMed: 8846004] [MGI Ref ID J:80625]
Chung YH; Joo KM; Lee YJ; Lee WB; Lee KH; Cha CI. 2004. Enhanced expression of erythropoietin in the central nervous system of SOD1(G93A) transgenic mice. Brain Res 1016(2):272-80. [PubMed: 15246865] [MGI Ref ID J:91260]
Chung YH; Joo KM; Lim HC; Cho MH; Kim D; Lee WB; Cha CI. 2005. Immunohistochemical study on the distribution of phosphorylated extracellular signal-regulated kinase (ERK) in the central nervous system of SOD1(G93A) transgenic mice. Brain Res 1050(1-2):203-9. [PubMed: 15978558] [MGI Ref ID J:99567]
Craven PA; Melhem MF; Phillips SL; DeRubertis FR. 2001. Overexpression of Cu2+/Zn2+ superoxide dismutase protects against early diabetic glomerular injury in transgenic mice. Diabetes 50(9):2114-25. [PubMed: 11522679] [MGI Ref ID J:107377]
Damiano M; Starkov AA; Petri S; Kipiani K; Kiaei M; Mattiazzi M; Flint Beal M; Manfredi G. 2006. Neural mitochondrial Ca capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice. J Neurochem 96(5):1349-61. [PubMed: 16478527] [MGI Ref ID J:106152]
De Vos KJ; Chapman AL; Tennant ME; Manser C; Tudor EL; Lau KF; Brownlees J; Ackerley S; Shaw PJ; McLoughlin DM; Shaw CE; Leigh PN; Miller CC; Grierson AJ. 2007. Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content. Hum Mol Genet 16(22):2720-8. [PubMed: 17725983] [MGI Ref ID J:129976]
De Winter F; Vo T; Stam FJ; Wisman LA; Bar PR; Niclou SP; van Muiswinkel FL; Verhaagen J. 2006. The expression of the chemorepellent Semaphorin 3A is selectively induced in terminal Schwann cells of a subset of neuromuscular synapses that display limited anatomical plasticity and enhanced vulnerability in motor neuron disease. Mol Cell Neurosci 32(1-2):102-17. [PubMed: 16677822] [MGI Ref ID J:111941]
DeRubertis FR; Craven PA; Melhem MF; Salah EM. 2004. Attenuation of renal injury in db/db mice overexpressing superoxide dismutase: evidence for reduced superoxide-nitric oxide interaction. Diabetes 53(3):762-8. [PubMed: 14988262] [MGI Ref ID J:88385]
Deng HX; Shi Y; Furukawa Y; Zhai H; Fu R; Liu E; Gorrie GH; Khan MS; Hung WY; Bigio EH; Lukas T; Dal Canto MC; O'Halloran TV; Siddique T. 2006. Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria. Proc Natl Acad Sci U S A 103(18):7142-7. [PubMed: 16636275] [MGI Ref ID J:109458]
Dewil M; Schurmans C; Starckx S; Opdenakker G; Van Den Bosch L; Robberecht W. 2005. Role of matrix metalloproteinase-9 in a mouse model for amyotrophic lateral sclerosis. Neuroreport 16(4):321-4. [PubMed: 15729130] [MGI Ref ID J:103535]
Dewil M; dela Cruz VF; Van Den Bosch L; Robberecht W. 2007. Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1(G93A)-induced motor neuron death. Neurobiol Dis 26(2):332-41. [PubMed: 17346981] [MGI Ref ID J:134849]
Di Giorgio FP; Carrasco MA; Siao MC; Maniatis T; Eggan K. 2007. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nat Neurosci 10(5):608-14. [PubMed: 17435754] [MGI Ref ID J:121861]
Elliott JL. 2001. Cytokine upregulation in a murine model of familial amyotrophic lateral sclerosis. Brain Res Mol Brain Res 95(1-2):172-8. [PubMed: 11687290] [MGI Ref ID J:72854]
Gal J; Strom AL; Kilty R; Zhang F; Zhu H. 2007. p62 accumulates and enhances aggregate formation in model systems of familial amyotrophic lateral sclerosis. J Biol Chem 282(15):11068-77. [PubMed: 17296612] [MGI Ref ID J:121167]
Geracitano R; Paolucci E; Prisco S; Guatteo E; Zona C; Longone P; Ammassari-Teule M; Bernardi G; Berretta N; Mercuri NB. 2003. Altered long-term corticostriatal synaptic plasticity in transgenic mice overexpressing human CU/ZN superoxide dismutase (GLY(93)-->ALA) mutation. Neuroscience 118(2):399-408. [PubMed: 12699776] [MGI Ref ID J:109423]
Gibb SL; Boston-Howes W; Lavina ZS; Gustincich S; Brown RH Jr; Pasinelli P; Trotti D. 2007. A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis. J Biol Chem 282(44):32480-90. [PubMed: 17823119] [MGI Ref ID J:126836]
Gilchrist CA; Gray DA; Stieber A; Gonatas NK; Kopito RR. 2005. Effect of ubiquitin expression on neuropathogenesis in a mouse model of familial amyotrophic lateral sclerosis. Neuropathol Appl Neurobiol 31(1):20-33. [PubMed: 15634228] [MGI Ref ID J:128568]
Gowing G; Philips T; Van Wijmeersch B; Audet JN; Dewil M; Van Den Bosch L; Billiau AD; Robberecht W; Julien JP. 2008. Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase. J Neurosci 28(41):10234-44. [PubMed: 18842883] [MGI Ref ID J:141126]
Guatteo E; Carunchio I; Pieri M; Albo F; Canu N; Mercuri NB; Zona C. 2007. Altered calcium homeostasis in motor neurons following AMPA receptor but not voltage-dependent calcium channels' activation in a genetic model of amyotrophic lateral sclerosis. Neurobiol Dis 28(1):90-100. [PubMed: 17706428] [MGI Ref ID J:134834]
Harraz MM; Marden JJ; Zhou W; Zhang Y; Williams A; Sharov VS; Nelson K; Luo M; Paulson H; Schoneich C; Engelhardt JF. 2008. SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model. J Clin Invest 118(2):659-70. [PubMed: 18219391] [MGI Ref ID J:131850]
Hegedus J; Putman CT; Gordon T. 2007. Time course of preferential motor unit loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 28(2):154-64. [PubMed: 17766128] [MGI Ref ID J:134803]
Jaarsma D; Haasdijk ED; Grashorn JA; Hawkins R; van Duijn W; Verspaget HW; London J; Holstege JC. 2000. Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1. Neurobiol Dis 7(6 Pt B):623-43. [PubMed: 11114261] [MGI Ref ID J:66700]
Jaarsma D; Teuling E; Haasdijk ED; De Zeeuw CI; Hoogenraad CC. 2008. Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice. J Neurosci 28(9):2075-88. [PubMed: 18305242] [MGI Ref ID J:134095]
Kikuchi H; Almer G; Yamashita S; Guegan C; Nagai M; Xu Z; Sosunov AA; McKhann GM 2nd; Przedborski S. 2006. Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model. Proc Natl Acad Sci U S A 103(15):6025-30. [PubMed: 16595634] [MGI Ref ID J:108290]
Kilic E; Weishaupt JH; Kilic U; Rohde G; Yulug B; Peters K; Hermann DM; Bahr M. 2004. The superoxide dismutase1 (sod1) G93A mutation does not promote neuronal injury after focal brain ischemia and optic nerve transection in mice. Neuroscience 128(2):359-64. [PubMed: 15350647] [MGI Ref ID J:92468]
Kong J; Xu Z. 1999. Peripheral axotomy slows motoneuron degeneration in a transgenic mouse line expressing mutant SOD1 G93A. J Comp Neurol 412(2):373-80. [PubMed: 10441762] [MGI Ref ID J:56912]
Kruidenier L; van Meeteren ME; Kuiper I; Jaarsma D; Lamers CB; Zijlstra FJ; Verspaget HW. 2003. Attenuated mild colonic inflammation and improved survival from severe DSS-colitis of transgenic Cu/Zn-SOD mice. Free Radic Biol Med 34(6):753-65. [PubMed: 12633752] [MGI Ref ID J:82695]
Kunishige M; Hill KA; Riemer AM; Farwell KD; Halangoda A; Heinmoller E; Moore SR; Turner DM; Sommer SS. 2001. Mutation frequency is reduced in the cerebellum of Big Blue mice overexpressing a human wild type SOD1 gene. Mutat Res 473(2):139-49. [PubMed: 11166032] [MGI Ref ID J:126863]
Larkin J; Clayton MM; Liu J; Feitelson MA. 2001. Chronic ethanol consumption stimulates hepatitis B virus gene expression and replication in transgenic mice. Hepatology 34(4 Pt 1):792-7. [PubMed: 11584377] [MGI Ref ID J:106512]
Levine JB; Kong J; Nadler M; Xu Z. 1999. Astrocytes interact intimately with degenerating motor neurons in mouse amyotrophic lateral sclerosis (ALS). Glia 28(3):215-24. [PubMed: 10559780] [MGI Ref ID J:59666]
Liu D; Wen J; Liu J; Li L. 1999. The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids. FASEB J 13(15):2318-28. [PubMed: 10593879] [MGI Ref ID J:58839]
Liu JQ; Zelko IN; Folz RJ. 2004. Reoxygenation-induced constriction in murine coronary arteries: the role of endothelial NADPH oxidase (gp91phox) and intracellular superoxide. J Biol Chem 279(23):24493-7. [PubMed: 15070892] [MGI Ref ID J:123986]
Lu L; Zheng L; Viera L; Suswam E; Li Y; Li X; Estevez AG; King PH. 2007. Mutant Cu/Zn-superoxide dismutase associated with amyotrophic lateral sclerosis destabilizes vascular endothelial growth factor mRNA and downregulates its expression. J Neurosci 27(30):7929-38. [PubMed: 17652584] [MGI Ref ID J:123248]
Martin LJ; Chen K; Liu Z. 2005. Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation. J Neurosci 25(27):6449-59. [PubMed: 16000635] [MGI Ref ID J:99428]
Mattiazzi M; D'Aurelio M; Gajewski CD; Martushova K; Kiaei M; Beal MF; Manfredi G. 2002. Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice. J Biol Chem 277(33):29626-33. [PubMed: 12050154] [MGI Ref ID J:132838]
Morimoto N; Nagai M; Ohta Y; Miyazaki K; Kurata T; Morimoto M; Murakami T; Takehisa Y; Ikeda Y; Kamiya T; Abe K. 2007. Increased autophagy in transgenic mice with a G93A mutant SOD1 gene. Brain Res 1167:112-7. [PubMed: 17689501] [MGI Ref ID J:124927]
Niessen HG; Angenstein F; Sander K; Kunz WS; Teuchert M; Ludolph AC; Heinze HJ; Scheich H; Vielhaber S. 2006. In vivo quantification of spinal and bulbar motor neuron degeneration in the G93A-SOD1 transgenic mouse model of ALS by T2 relaxation time and apparent diffusion coefficient. Exp Neurol 201(2):293-300. [PubMed: 16740261] [MGI Ref ID J:114432]
Niessen HG; Debska-Vielhaber G; Sander K; Angenstein F; Ludolph AC; Hilfert L; Willker W; Leibfritz D; Heinze HJ; Kunz WS; Vielhaber S. 2007. Metabolic progression markers of neurodegeneration in the transgenic G93A-SOD1 mouse model of amyotrophic lateral sclerosis. Eur J Neurosci 25(6):1669-77. [PubMed: 17432958] [MGI Ref ID J:122876]
Puttaparthi K; Wojcik C; Rajendran B; DeMartino GN; Elliott JL. 2003. Aggregate formation in the spinal cord of mutant SOD1 transgenic mice is reversible and mediated by proteasomes. J Neurochem 87(4):851-60. [PubMed: 14622116] [MGI Ref ID J:86631]
Reinholz MM; Merkle CM; Poduslo JF. 1999. Therapeutic benefits of putrescine-modified catalase in a transgenic mouse model of familial amyotrophic lateral sclerosis. Exp Neurol 159(1):204-16. [PubMed: 10486188] [MGI Ref ID J:57736]
Taylor DM; Gibbs BF; Kabashi E; Minotti S; Durham HD; Agar JN. 2007. Tryptophan 32 potentiates aggregation and cytotoxicity of a copper/zinc superoxide dismutase mutant associated with familial amyotrophic lateral sclerosis. J Biol Chem 282(22):16329-35. [PubMed: 17389599] [MGI Ref ID J:122717]
Thireau J; Poisson D; Zhang BL; Gillet L; Le Pecheur M; Andres C; London J; Babuty D. 2008. Increased heart rate variability in mice overexpressing the Cu/Zn superoxide dismutase. Free Radic Biol Med 45(4):396-403. [PubMed: 18513493] [MGI Ref ID J:137769]
Tu PH; Raju P; Robinson KA; Gurney ME; Trojanowski JQ; Lee VM. 1996. Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions. Proc Natl Acad Sci U S A 93(7):3155-60. [PubMed: 8610185] [MGI Ref ID J:76718]
Vlug AS; Teuling E; Haasdijk ED; French P; Hoogenraad CC; Jaarsma D. 2005. ATF3 expression precedes death of spinal motoneurons in amyotrophic lateral sclerosis-SOD1 transgenic mice and correlates with c-Jun phosphorylation, CHOP expression, somato-dendritic ubiquitination and Golgi fragmentation. Eur J Neurosci 22(8):1881-94. [PubMed: 16262628] [MGI Ref ID J:102918]
Vukosavic S; Dubois-Dauphin M; Romero N; Przedborski S. 1999. Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem 73(6):2460-8. [PubMed: 10582606] [MGI Ref ID J:58488]
Wang Y; Mao XO; Xie L; Banwait S; Marti HH; Greenberg DA; Jin K. 2007. Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice. J Neurosci 27(2):304-7. [PubMed: 17215390] [MGI Ref ID J:117304]
Wootz H; Hansson I; Korhonen L; Lindholm D. 2006. XIAP decreases caspase-12 cleavage and calpain activity in spinal cord of ALS transgenic mice. Exp Cell Res 312(10):1890-8. [PubMed: 16566922] [MGI Ref ID J:111367]
Wootz H; Hansson I; Korhonen L; Napankangas U; Lindholm D. 2004. Caspase-12 cleavage and increased oxidative stress during motoneuron degeneration in transgenic mouse model of ALS. Biochem Biophys Res Commun 322(1):281-6. [PubMed: 15313203] [MGI Ref ID J:92029]
Xu W; Chi L; Row BW; Xu R; Ke Y; Xu B; Luo C; Kheirandish L; Gozal D; Liu R. 2004. Increased oxidative stress is associated with chronic intermittent hypoxia-mediated brain cortical neuronal cell apoptosis in a mouse model of sleep apnea. Neuroscience 126(2):313-23. [PubMed: 15207349] [MGI Ref ID J:91264]
Zhao P; Ignacio S; Beattie EC; Abood ME. 2008. Altered presymptomatic AMPA and cannabinoid receptor trafficking in motor neurons of ALS model mice: implications for excitotoxicity. Eur J Neurosci 27(3):572-9. [PubMed: 18279310] [MGI Ref ID J:132266]
Zhao Z; Lange DJ; Voustianiouk A; MacGrogan D; Ho L; Suh J; Humala N; Thiyagarajan M; Wang J; Pasinetti GM. 2006. A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis. BMC Neurosci 7:29. [PubMed: 16584562] [MGI Ref ID J:111122]
Zona C; Pieri M; Carunchio I. 2006. Voltage-dependent sodium channels in spinal cord motor neurons display rapid recovery from fast inactivation in a mouse model of amyotrophic lateral sclerosis. J Neurophysiol 96(6):3314-22. [PubMed: 16899637] [MGI Ref ID J:136461]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Mating System F1 x Hemizygote (Female x Male) Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $212.80 Female or Male Hemizygous for Tg(SOD1)2Gur *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $230.75 B6SJLF1/J (100012) x Hemizygous for Tg(SOD1)2Gur
Additional Supply Details
| Supply Notes |
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| Pricing for International shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $276.70 Female or Male Hemizygous for Tg(SOD1)2Gur *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $300.00 B6SJLF1/J (100012) x Hemizygous for Tg(SOD1)2Gur
Additional Supply Details
| Supply Notes |
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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Control Information
| Control | ||
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| Noncarrier female | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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JAX® Mice & Services Conditions of Use
“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. THE LABORATORY EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.
No Liability
In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.
MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.
Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.