Strain Name:

SKH2/J

Stock Number:

002335

Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Specieslaboratory mouse
GenerationF51p

Appearance
pigmented, without hair
Related Genotype: a/a Hrhr/Hrhr

Important Note
This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss that is already severe by three months of age (Johnson et al. 2000).

Description
Mice homozygous for the hr spontaneous mutation have a higher incidence and earlier onset of leukemia, reducible by virus-specific antibody. Deficiency of splenic T helper cells (Ly-1+) may account for low cellular immune response of homozygous mutant mice. The coat is normal on hr/hr mice up to 10 days but then hair is lost from the follicle. Waves of hair growth with few thin fuzzy hairs ocur at monthly intervals for some time but homozygotes eventually become continuously hairless. Vibrissae are repeatedly regrown and shed, becoming more abnormal with age. Toenails are long and curved. There is hyperkeratosis of stratified epithelium and the upper part of hair canals beginning at 14 days. Hair club formation is abnormal. Cysts form from the hyperkeratotic upper part of hair canals and sheaths of abnormal follicles stranded in dermis. Some cysts also form from sebaceous glands. All cysts undergo sebaceous transformation and later keratinization. Black juvenile hair coat and tanning is a dominant trait for this SKH2 substrain. This mutant is for research on ultraviolet radiation induced melanogenesis.

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Cdh23ahl allele
001137   129P1/ReJ
000690   129P3/J
000691   129X1/SvJ
000646   A/J
000647   A/WySnJ
003070   ALR/LtJ
003072   ALS/LtJ
004502   B6;AKR-Lxl2/GrsrJ
001026   BALB/cByJ
000653   BUB/BnJ
005494   C3.129S1(B6)-Grm1rcw/J
000664   C57BL/6J
004764   C57BL/6J-Cdh23v-8J/J
003129   C57BL/6J-Epha4rb-2J/GrsrJ
004820   C57BL/6J-Kcne12J/J
004703   C57BL/6J-Kcnq2Nmf134/J
004811   C57BL/6J-nmf110/J
004812   C57BL/6J-nmf111/J
004747   C57BL/6J-nmf118/J
004656   C57BL/6J-nmf88/J
004391   C57BL/6J-Chr 13A/J/NaJ
004385   C57BL/6J-Chr 7A/J/NaJ
000662   C57BLKS/J
000667   C57BR/cdJ
000668   C57L/J
000669   C58/J
000657   CE/J
000670   DBA/1J
001140   DBA/1LacJ
000671   DBA/2J
007048   DBA/2J-Gpnmb+/SjJ
002106   KK/HlJ
000675   LG/J
000676   LP/J
000677   MA/MyJ
001976   NOD/ShiLtJ
002050   NOR/LtJ
000679   P/J
002747   SENCARB/PtJ
003392   STOCK Crb1rd8/J
View Strains carrying   Cdh23ahl     (40 strains)

Strains carrying   Hrhr allele
001737   B6.A-H2-T18a.HRS-Hrhr/J
002922   D2.HRS-Hrhr/J
000673   HRS/J
001103   HRS/J-Hrhr Esdb/+ Esdb/J
000147   WLHR/LeJ
View Strains carrying   Hrhr     (5 strains)

Strains carrying   mt-Trm2 allele
003070   ALR/LtJ
View Strains carrying   mt-Trm2     (1 strain)

Strains carrying other alleles of Cdh23
002756   B6.CAST-Cdh23Ahl+/Kjn
002432   B6J x B6.C-H2-Kbm1/ByJ-Cdh23v-J/J
002552   C57BL/6J-Cdh23v-2J/J
004764   C57BL/6J-Cdh23v-8J/J
004819   C57BL/6J-Cdh23v-9J/J
005016   CByJ;B6-Cdh23v-10J/J
000275   V/LeJ
View Strains carrying other alleles of Cdh23     (7 strains)

Strains carrying other alleles of Hr
007621   B6.129S6-Hrtm1Cct/J
007622   B6;SJL-Tg(KRT14-Hr)551Cct/J
000758   C57BL/6J-Hbbp Hrrh-7J/J
000266   RHJ/Le
001591   RHJ/LeJ
View Strains carrying other alleles of Hr     (5 strains)

Strains carrying other alleles of mt-Tr
000646   A/J
003072   ALS/LtJ
001976   NOD/ShiLtJ
000684   NZB/BlNJ
View Strains carrying other alleles of mt-Tr     (4 strains)

Additional Web Information

Genetic Quality Control Annual Report
JAX® NOTES, January 1989; 436. Phenotypic abnormalities in hr-locus mutants.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms
Alopecia Universalis Congenita; ALUNC - Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Atrichia with Papular Lesions; APL - Models with phenotypic similarity to human disease where etiologies involve orthologs.1
1 Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Hrhr/Hrhr

        Background Not Specified
  • skin/coat/nails phenotype
  • abnormal skin morphology (MGI Ref ID J:2409)
    • thickened cutis
    • abnormal dermis reticular layer morphology (MGI Ref ID J:2409)
      • cystic
    • dermal cysts (MGI Ref ID J:14889)
    • epidermal hyperplasia (MGI Ref ID J:14940)
    • hyperkeratosis (MGI Ref ID J:14940)
  • alopecia (MGI Ref ID J:2409)
    • beginning ~15 days of age and progressing from nose back
  • deformed nails (MGI Ref ID J:2409)
    • curved
  • endocrine/exocrine gland phenotype
  • abnormal mammary gland morphology (MGI Ref ID J:2409)
    • small
    • nipple at bottom of cup-shaped depression in skin
    • no ducts
  • sebaceous gland atrophy (MGI Ref ID J:2409)
  • reproductive system phenotype
  • abnormal mammary gland morphology (MGI Ref ID J:2409)
    • small
    • nipple at bottom of cup-shaped depression in skin
    • no ducts
  • behavior/neurological phenotype
  • abnormal nursing (MGI Ref ID J:2409)
    • failure

Hrhr/Hrhr

        HRS/J
  • hearing/vestibular/ear phenotype
  • absent linear vestibular evoked potential (MGI Ref ID J:116914)
    • VESPs are absent at the maximum stimulus intensity used
  • tumorigenesis
  • leukemia (MGI Ref ID J:5726)
    • increased incidence
    • increased incidence
    • at 8 to 10 months of age 45% of homozygotes have lymphoid leukemia, compared with only 1% in heterozygotes, and approximately 72% of these homozygotes develop myeloid leukemia later in life up to 18 months of age
  • hematopoietic system phenotype
  • decreased T cell number (MGI Ref ID J:6087)
    • of CD5+ T cells
  • decreased T cell proliferation (MGI Ref ID J:6375)
    • to alloantigens by T helper cells
  • increased macrophage cell number (MGI Ref ID J:150402)
    • although heterozygotes and homozygotes have the same total number of peritoneal cells, the percentage expressing Mac-1 is an average of 30% in homozygotes versus an average of 14% in heterozygotes
  • immune system phenotype
  • decreased T cell number (MGI Ref ID J:6087)
    • of CD5+ T cells
  • decreased T cell proliferation (MGI Ref ID J:6375)
    • to alloantigens by T helper cells
  • increased macrophage cell number (MGI Ref ID J:150402)
    • although heterozygotes and homozygotes have the same total number of peritoneal cells, the percentage expressing Mac-1 is an average of 30% in homozygotes versus an average of 14% in heterozygotes
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Vestibular and Hearing Defects
      Age related hearing loss

Sensorineural Research
Vestibular and Hearing Defects
      Age related hearing loss

Cdh23ahl related

Neurobiology Research
Vestibular and Hearing Defects
      Age related hearing loss

Sensorineural Research
Vestibular and Hearing Defects
      Age related hearing loss

Hrhr related

Cancer Research
Increased Tumor Incidence
      Leukemia: lymphocytic
      Lymphomas: thymic
      Skin Cancers: Induced
Toxicology

Cardiovascular Research
Diet-Induced Atherosclerosis
      Relatively Resistant

Dermatology Research
Skin and Hair Texture Defects

Immunology and Inflammation Research
Immunodeficiency Associated with Other Defects

Research Tools
Toxicology Research
      drug/compound testing

Genes & Alleles

Gene & Allele Information

 
Allele Symbol Cdh23ahl
Allele Name age related hearing loss 1
Allele Type QTL
Common Name(s) Cdh23753A; mdfw;
Strain of Originmultiple strains
Gene Symbol and Name Cdh23, cadherin 23 (otocadherin)
Chromosome 10
Gene Common Name(s) 4930542A03Rik; DFNB12; DKFZp434P2350; FLJ00233; FLJ36499; KIAA1774; KIAA1812; MGC102761; RIKEN cDNA 4930542A03 gene; USH1D; W; age related hearing loss 1; ahl; bob; bobby; bus; bustling; mdfw; modifier of deaf waddler; neuroscience mutagenesis facility, 112; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; nmf112; nmf181; nmf252; sals; salsa; v; waltzer;
Molecular Note Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. Further analysis has identified an association between ahl and a G to A transition at nucleotide position 753 of Cdh23. This hypomorphic allele causes in frame skipping of exon 7 and reduced message stability. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129P1/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129X1/SvJ, NOR/LtJ, A/J, C57BL/6, NOD/LtJ, DBA/2J, ALR/LtJ, C57L/J. Strains classified with ahl that DO NOT carry this mutation include: C3H/HeSnJ, I/LnJ,YBR/Ei, MRL/MpJ. [MGI Ref ID J:86905]
 
Allele Symbol Hrhr
Allele Name hairless
Allele Type Spontaneous
Common Name(s) hr;
Gene Symbol and Name Hr, hairless
Chromosome 14
Gene Common Name(s) ALUNC; AU; FLJ98880; HSA277165; MUHH; MUHH1; N; ba; baldy; bldy; rh; rh-bmh; rhino-bald Mill Hill;
Molecular Note The hr allele is the result of a retroviral integration. Insertion of murine leukemia proviral sequences into intron 6 results in aberrant splicing of the gene. [MGI Ref ID J:19624] [MGI Ref ID J:92053] [MGI Ref ID J:9252]
 
Allele Symbol mt-Trm2
Allele Name mutation 2
Allele Type Spontaneous
Common Name(s) 9A;
Strain of Originvarious
Gene Symbol and Name mt-Tr, mitochondrially encoded tRNA arginine
Chromosome MT
Gene Common Name(s) TrnR tRNA; tRNA; tRNA-Arg;
General Note This polymorphism is present in ALR/Lt, NOD/ShiLtDvs, and SKH2/J. A variant with 10 adenines is found in A/J, ALS/Lt, NOD/ShiLtJ and NZB/B1NJ.
Molecular Note The adenine repeat in the D stem is polymorphic with 9 adenines in this allele. [MGI Ref ID J:67312] [MGI Ref ID J:97969]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Additional References

Cachon-Gonzalez MB; Fenner S; Coffin JM; Moran C; Best S; Stoye JP. 1994. Structure and expression of the hairless gene of mice. Proc Natl Acad Sci U S A 91(16):7717-21. [PubMed: 8052649]  [MGI Ref ID J:19624]

Morrissey PJ; Parkinson DR; Schwartz RS; Waksal SD. 1980. Immunologic abnormalities in HRS/J mice. I. Specific deficit in T lymphocyte helper function in a mutant mouse. J Immunol 125(4):1558-62. [PubMed: 6447727]  [MGI Ref ID J:6375]

Reske-Kunz AB; Scheid MP; Boyse EA. 1979. Disproportion in T-cell subpopulations in immunodeficient mutant hr/hr mice. J Exp Med 149(1):228-33. [PubMed: 310859]  [MGI Ref ID J:6087]

Stoye JP; Fenner S; Greenoak GE; Moran C; Coffin JM. 1988. Role of endogenous retroviruses as mutagens: the hairless mutation of mice. Cell 54(3):383-91. [PubMed: 2840205]  [MGI Ref ID J:9252]

Cdh23ahl related

Davis RR; Newlander JK; Ling X; Cortopassi GA; Krieg EF; Erway LC. 2001. Genetic basis for susceptibility to noise-induced hearing loss in mice. Hear Res 155(1-2):82-90. [PubMed: 11335078]  [MGI Ref ID J:69679]

Di Palma F; Pellegrino R; Noben-Trauth K. 2001. Genomic structure, alternative splice forms and normal and mutant alleles of cadherin 23 (Cdh23). Gene 281(1-2):31-41. [PubMed: 11750125]  [MGI Ref ID J:73941]

Johnson KR; Erway LC; Cook SA; Willott JF; Zheng QY. 1997. A major gene affecting age-related hearing loss in C57BL/6J mice Hear Res 114(1-2):83-92. [PubMed: 9447922]  [MGI Ref ID J:44966]

Johnson KR; Longo-Guess C; Gagnon LH; Yu H; Zheng QY. 2008. A locus on distal chromosome 11 (ahl8) and its interaction with Cdh23 ahl underlie the early onset, age-related hearing loss of DBA/2J mice. Genomics 92(4):219-25. [PubMed: 18662770]  [MGI Ref ID J:139223]

Johnson KR; Zheng QY; Bykhovskaya Y; Spirina O; Fischel-Ghodsian N. 2001. A nuclear-mitochondrial DNA interaction affecting hearing impairment in mice. Nat Genet 27(2):191-4. [PubMed: 11175788]  [MGI Ref ID J:67312]

Johnson KR; Zheng QY; Noben-Trauth K. 2006. Strain background effects and genetic modifiers of hearing in mice. Brain Res 1091(1):79-88. [PubMed: 16579977]  [MGI Ref ID J:110459]

Johnson KR; Zheng QY; Weston MD; Ptacek LJ; Noben-Trauth K. 2005. The Mass1(frings) mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC. Genomics 85(5):582-90. [PubMed: 15820310]  [MGI Ref ID J:97534]

Keithley EM; Canto C; Zheng QY; Fischel-Ghodsian N; Johnson KR. 2004. Age-related hearing loss and the ahl locus in mice. Hear Res 188(1-2):21-8. [PubMed: 14759567]  [MGI Ref ID J:87783]

Liu X; Bulgakov OV; Darrow KN; Pawlyk B; Adamian M; Liberman MC; Li T. 2007. Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells. Proc Natl Acad Sci U S A 104(11):4413-8. [PubMed: 17360538]  [MGI Ref ID J:118927]

Mathews CE; Leiter EH. 1999. Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait. Diabetes 48(11):2189-96. [PubMed: 10535453]  [MGI Ref ID J:109893]

Nadeau JH. 2003. Modifier genes and protective alleles in humans and mice. Curr Opin Genet Dev 13(3):290-5. [PubMed: 12787792]  [MGI Ref ID J:88012]

Noben-Trauth K; Zheng QY; Johnson KR. 2003. Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss. Nat Genet 35(1):21-3. [PubMed: 12910270]  [MGI Ref ID J:86905]

Noben-Trauth K; Zheng QY; Johnson KR; Nishina PM. 1997. mdfw: a deafness susceptibility locus that interacts with deaf waddler (dfw). Genomics 44(3):266-72. [PubMed: 9325047]  [MGI Ref ID J:38429]

Vazquez AE; Jimenez AM; Martin GK; Luebke AE; Lonsbury-Martin BL. 2004. Evaluating cochlear function and the effects of noise exposure in the B6.CAST+Ahl mouse with distortion product otoacoustic emissions. Hear Res 194(1-2):87-96. [PubMed: 15276680]  [MGI Ref ID J:117746]

Zheng QY; Johnson KR. 2001. Hearing loss associated with the modifier of deaf waddler (mdfw) locus corresponds with age-related hearing loss in 12 inbred strains of mice. Hear Res 154(1-2):45-53. [PubMed: 11423214]  [MGI Ref ID J:70964]

Hrhr related

Aberg KM; Man MQ; Gallo RL; Ganz T; Crumrine D; Brown BE; Choi EH; Kim DK; Schroder JM; Feingold KR; Elias PM. 2008. Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. J Invest Dermatol 128(4):917-25. [PubMed: 17943185]  [MGI Ref ID J:135506]

Ahmad W; Panteleyev AA; Christiano AM. 1999. The molecular basis of congenital atrichia in humans and mice: mutations in the hairless gene. J Investig Dermatol Symp Proc 4(3):240-3. [PubMed: 10674375]  [MGI Ref ID J:59939]

Astner S; Wu A; Chen J; Philips N; Rius-Diaz F; Parrado C; Mihm MC; Goukassian DA; Pathak MA; Gonzalez S. 2007. Dietary lutein/zeaxanthin partially reduces photoaging and photocarcinogenesis in chronically UVB-irradiated Skh-1 hairless mice. Skin Pharmacol Physiol 20(6):283-91. [PubMed: 17717424]  [MGI Ref ID J:128747]

Balansky RM; Izzotti A; D'Agostini F; Camoirano A; Bagnasco M; Lubet RA; De Flora S. 2003. Systemic genotoxic effects produced by light, and synergism with cigarette smoke in the respiratory tract of hairless mice. Carcinogenesis 24(9):1525-32. [PubMed: 12844483]  [MGI Ref ID J:85507]

Brooke HC. 1926. Hairless mice J Hered 17:173-74.  [MGI Ref ID J:2405]

Cachon-Gonzalez MB; Fenner S; Coffin JM; Moran C; Best S; Stoye JP. 1994. Structure and expression of the hairless gene of mice. Proc Natl Acad Sci U S A 91(16):7717-21. [PubMed: 8052649]  [MGI Ref ID J:19624]

Cachon-Gonzalez MB; San-Jose I; Cano A; Vega JA; Garcia N; Freeman T; Schimmang T; Stoye JP. 1999. The hairless gene of the mouse: relationship of phenotypic effects with expression profile and genotype. Dev Dyn 216(2):113-26. [PubMed: 10536052]  [MGI Ref ID J:57947]

Clark EA; Shultz LD; Pollack SB. 1981. Mutations in mice that influence natural killer (NK) cell activity. Immunogenetics 12(5-6):601-13. [PubMed: 6971254]  [MGI Ref ID J:6485]

Crew FAE; Mirskaia L. 1931. The character of "hairless" in the mouse J Genet 25:17-24.  [MGI Ref ID J:2409]

DERINGER MK. 1956. The effect of subcutaneous inoculation of 4-o-tolylazo-o-toluidine in strain HR mice. J Natl Cancer Inst 17(4):533-9. [PubMed: 13367821]  [MGI Ref ID J:24688]

Doig J; Anderson C; Lawrence NJ; Selfridge J; Brownstein DG; Melton DW. 2006. Mice with skin-specific DNA repair gene (Ercc1) inactivation are hypersensitive to ultraviolet irradiation-induced skin cancer and show more rapid actinic progression. Oncogene 25(47):6229-38. [PubMed: 16682947]  [MGI Ref ID J:115849]

Dunn TB; Deringer MK. 1968. Reticulum cell neoplasm, type B, or the Hodgkin's-like lesion of the mouse. J Natl Cancer Inst 40(4):771-821. [PubMed: 4869134]  [MGI Ref ID J:2417]

Dwivedi C; Valluri HB; Guan X; Agarwal R. 2006. Chemopreventive effects of alpha-santalol on ultraviolet B radiation-induced skin tumor development in SKH-1 hairless mice. Carcinogenesis 27(9):1917-22. [PubMed: 16679309]  [MGI Ref ID J:113353]

Egberts F; Heinrich M; Jensen JM; Winoto-Morbach S; Pfeiffer S; Wickel M; Schunck M; Steude J; Saftig P; Proksch E; Schutze S. 2004. Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation. J Cell Sci 117(Pt 11):2295-307. [PubMed: 15126630]  [MGI Ref ID J:89747]

Elias PM; Arbiser J; Brown BE; Rossiter H; Man MQ; Cerimele F; Crumrine D; Gunathilake R; Choi EH; Uchida Y; Tschachler E; Feingold KR. 2008. Epidermal vascular endothelial growth factor production is required for permeability barrier homeostasis, dermal angiogenesis, and the development of epidermal hyperplasia: implications for the pathogenesis of psoriasis. Am J Pathol 173(3):689-99. [PubMed: 18688025]  [MGI Ref ID J:139588]

Fischer SM; Pavone A; Mikulec C; Langenbach R; Rundhaug JE. 2007. Cyclooxygenase-2 expression is critical for chronic UV-induced murine skin carcinogenesis. Mol Carcinog 46(5):363-71. [PubMed: 17219415]  [MGI Ref ID J:121635]

Fraser FC. 1946. The expression and interaction of hereditary factors producing hypotrichosis in the mouse: histology and experimental results. Can J Res 24:10-25.  [MGI Ref ID J:14940]

Gallagher CH; Canfield PJ; Greenoak GE; Reeve VE. 1984. Characterization and histogenesis of tumors in the hairless mouse produced by low-dosage incremental ultraviolet radiation. J Invest Dermatol 83(3):169-74. [PubMed: 6470519]  [MGI Ref ID J:127204]

Gates AH; Arundell FD; Karasek MA. 1969. Hereditary defect of the pilosebaceous unit in a new double mutant mouse. J Invest Dermatol 52(2):115-8. [PubMed: 5774889]  [MGI Ref ID J:126589]

Hachem JP; Houben E; Crumrine D; Man MQ; Schurer N; Roelandt T; Choi EH; Uchida Y; Brown BE; Feingold KR; Elias PM. 2006. Serine Protease Signaling of Epidermal Permeability Barrier Homeostasis. J Invest Dermatol 126(9):2074-2086. [PubMed: 16691196]  [MGI Ref ID J:111734]

Halin C; Fahrngruber H; Meingassner JG; Bold G; Littlewood-Evans A; Stuetz A; Detmar M. 2008. Inhibition of chronic and acute skin inflammation by treatment with a vascular endothelial growth factor receptor tyrosine kinase inhibitor. Am J Pathol 173(1):265-77. [PubMed: 18535184]  [MGI Ref ID J:137380]

Heiniger HJ; Huebner RJ; Meier H. 1976. Effect of allelic substitutions at the hairless locus on endogenous ecotropic murine leukemia virus titers and leukemogenesis. J Natl Cancer Inst 56(5):1073-4. [PubMed: 186616]  [MGI Ref ID J:5726]

Heiniger HJ; Meier H; Kaliss N; Cherry M; Chen HW; Stoner RD. 1974. Hereditary immunodeficiency and leukemogenesis in HRS-J mice. Cancer Res 34(1):201-11. [PubMed: 4588546]  [MGI Ref ID J:24605]

Heston WE. 1963. Genetics of Neoplasia. In: Methodology in Mammalian Genetics. Holden-Day, San Francisco.  [MGI Ref ID J:23470]

Hiai H; Morrissey P; Khiroya R; Schwartz RS. 1977. Selective expression of xenotropic virus in congenic HRS/J (hairless) mice. Nature 270(5634):247-9. [PubMed: 201855]  [MGI Ref ID J:5908]

Jensen JM; Schutze S; Forl M; Kronke M; Proksch E. 1999. Roles for tumor necrosis factor receptor p55 and sphingomyelinase in repairing the cutaneous permeability barrier. J Clin Invest 104(12):1761-70. [PubMed: 10606630]  [MGI Ref ID J:59056]

Jeong SK; Kim HJ; Youm JK; Ahn SK; Choi EH; Sohn MH; Kim KE; Hong JH; Shin DM; Lee SH. 2008. Mite and cockroach allergens activate protease-activated receptor 2 and delay epidermal permeability barrier recovery. J Invest Dermatol 128(8):1930-9. [PubMed: 18305573]  [MGI Ref ID J:141618]

Johnson DA; Meier H. 1981. Immune responsiveness of HRS/J mice to syngeneic lymphoma cells. J Immunol 127(2):461-4. [PubMed: 6265551]  [MGI Ref ID J:6535]

Jones SM; Johnson KR; Yu H; Erway LC; Alagramam KN; Pollak N; Jones TA. 2005. A quantitative survey of gravity receptor function in mutant mouse strains. J Assoc Res Otolaryngol 6(4):297-310. [PubMed: 16235133]  [MGI Ref ID J:116914]

Kajiya K; Hirakawa S; Detmar M. 2006. Vascular endothelial growth factor-A mediates ultraviolet B-induced impairment of lymphatic vessel function. Am J Pathol 169(4):1496-503. [PubMed: 17003502]  [MGI Ref ID J:113381]

Kato M; Ohgami N; Kawamoto Y; Tsuzuki T; Hossain K; Yanagishita T; Ohshima Y; Tsuboi H; Yamanoshita O; Matsumoto Y; Takahashi M; Nakashima I. 2007. Protective effect of hyperpigmented skin on UV-mediated cutaneous cancer development. J Invest Dermatol 127(5):1244-9. [PubMed: 17159911]  [MGI Ref ID J:121091]

Kato M; Takeda K; Kawamoto Y; Tsuzuki T; Kato Y; Ohno T; Hossain K; Iftakhar-E-Khuda I; Ohgami N; Isobe K; Takahashi M; Nakashima I. 2006. Novel Hairless RET-Transgenic Mouse Line with Melanocytic Nevi and Anagen Hair Follicles. J Invest Dermatol 126(11):2547-50. [PubMed: 16778787]  [MGI Ref ID J:113399]

Kaya G; Tran C; Sorg O; Hotz R; Grand D; Carraux P; Didierjean L; Stamenkovic I; Saurat JH. 2006. Hyaluronate fragments reverse skin atrophy by a CD44-dependent mechanism. PLoS Med 3(12):e493. [PubMed: 17177600]  [MGI Ref ID J:134166]

Keeler CE. 1931. The Independence of Dominant Spotting and Recessive Spotting ('Piebald') in the House Mouse. Proc Natl Acad Sci U S A 17(2):101-2. [PubMed: 16587618]  [MGI Ref ID J:153352]

Kimura Y; Sumiyoshi M. 2009. Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice. J Nutr 139(11):2079-86. [PubMed: 19776181]  [MGI Ref ID J:153732]

Kinley JS; Moan J; Dall'Aqua F; Young AR. 1994. Quantitative assessment of epidermal melanogenesis in C3H/Tif hr/hr mice treated with topical furocoumarins and UVA radiation. J Invest Dermatol 103(1):97-103. [PubMed: 8027588]  [MGI Ref ID J:19313]

Kondo T; Shiomoto Y; Kondo T; and Kubo S. 1997. The "NOA" MOUSE; A NEW HAIR-DEFICIENT MUTANT (A POSSIBLE ANIMAL MODEL OF ALLERGIC DERMATITIS) Mouse Genome 95(3):698-700.  [MGI Ref ID J:43274]

MONTAGNA W; CHASE HB; MELARAGNO HP. 1952. The skin of hairless mice. I. The formation of cysts and the distribution of lipids. J Invest Dermatol 19(1):83-94. [PubMed: 14946445]  [MGI Ref ID J:14889]

Mann SJ. 1971. Hair loss and cyst formation in hairless and rhino mutant mice. Anat Rec 170(4):485-99. [PubMed: 5118596]  [MGI Ref ID J:5239]

Meier H; Myers DD; Huebner RJ. 1969. Genetic control by the hr-locus of susceptibility and resistance to leukemia. Proc Natl Acad Sci U S A 63(3):759-66. [PubMed: 4310515]  [MGI Ref ID J:24786]

Michna L; Wagner GC; Lou YR; Xie JG; Peng QY; Lin Y; Carlson K; Shih WJ; Conney AH; Lu YP. 2006. Inhibitory effects of voluntary running wheel exercise on UVB-induced skin carcinogenesis in SKH-1 mice. Carcinogenesis 27(10):2108-15. [PubMed: 16699173]  [MGI Ref ID J:113354]

Morrissey PJ; Parkinson DR; Schwartz RS; Waksal SD. 1980. Immunologic abnormalities in HRS/J mice. I. Specific deficit in T lymphocyte helper function in a mutant mouse. J Immunol 125(4):1558-62. [PubMed: 6447727]  [MGI Ref ID J:6375]

Mucenski ML; Bedigian HG; Shull MM; Copeland NG; Jenkins NA. 1988. Comparative molecular genetic analysis of lymphomas from six inbred mouse strains. J Virol 62(3):839-46. [PubMed: 2828679]  [MGI Ref ID J:25442]

Murphy ED. 1966. Characteristic Tumors. In: Biology of the Laboratory Mouse. McGraw-Hill, New York.  [MGI Ref ID J:24830]

Panteleyev AA; Botchkareva NV; Sundberg JP; Christiano AM; Paus R. 1999. The role of the hairless (hr) gene in the regulation of hair follicle catagen transformation. Am J Pathol 155(1):159-71. [PubMed: 10393848]  [MGI Ref ID J:56076]

Panteleyev AA; van der Veen C; Rosenbach T; Muller-Rover S; Sokolov VE ; Paus R. 1998. Towards defining the pathogenesis of the hairless phenotype. J Invest Dermatol 110(6):902-7. [PubMed: 9620297]  [MGI Ref ID J:47743]

Pauling L. 1991. Effect of ascorbic acid on incidence of spontaneous mammary tumors and UV-light-induced skin tumors in mice. Am J Clin Nutr 54(6 Suppl):1252S-1255S. [PubMed: 1962578]  [MGI Ref ID J:634]

Pirinen E; Kuulasmaa T; Pietila M; Heikkinen S; Tusa M; Itkonen P; Boman S; Skommer J; Virkamaki A; Hohtola E; Kettunen M; Fatrai S; Kansanen E; Koota S; Niiranen K; Parkkinen J; Levonen AL; Yla-Herttuala S; Hiltunen JK; Alhonen L; Smith U; Janne J; Laakso M. 2007. Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism. Mol Cell Biol 27(13):4953-67. [PubMed: 17485446]  [MGI Ref ID J:122759]

Pottathil R; Meier H; Huebner RJ. 1978. Suppression of leukemogenesis in hairless mice by anti-type C viral immune gamma globulins. Naturwissenschaften 65(8):443-4. [PubMed: 213736]  [MGI Ref ID J:6059]

Reske-Kunz AB; Scheid MP; Boyse EA. 1979. Disproportion in T-cell subpopulations in immunodeficient mutant hr/hr mice. J Exp Med 149(1):228-33. [PubMed: 310859]  [MGI Ref ID J:6087]

Roelandt T; Giddelo C; Heughebaert C; Denecker G; Hupe M; Crumrine D; Kusuma A; Haftek M; Roseeuw D; Declercq W; Feingold KR; Elias PM; Hachem JP. 2009. The 'caveolae brake hypothesis' and the epidermal barrier. J Invest Dermatol 129(4):927-36. [PubMed: 19005485]  [MGI Ref ID J:150227]

Sato J; Yanai M; Hirao T; Denda M. 2000. Water content and thickness of the stratum corneum contribute to skin surface morphology. Arch Dermatol Res 292(8):412-7. [PubMed: 10994776]  [MGI Ref ID J:116955]

Sitaru C; Chiriac MT; Mihai S; Buning J; Gebert A; Ishiko A; Zillikens D. 2006. Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice. J Immunol 177(5):3461-8. [PubMed: 16920988]  [MGI Ref ID J:139521]

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Starcher B; O'Neal P; Granstein RD; Beissert S. 1996. Inhibition of neutrophil elastase suppresses the development of skin tumors in hairless mice. J Invest Dermatol 107(2):159-63. [PubMed: 8757756]  [MGI Ref ID J:34446]

Stoye JP; Fenner S; Greenoak GE; Moran C; Coffin JM. 1988. Role of endogenous retroviruses as mutagens: the hairless mutation of mice. Cell 54(3):383-91. [PubMed: 2840205]  [MGI Ref ID J:9252]

Sundberg JP (ed.). 1994. . In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton.  [MGI Ref ID J:30359]

Sundberg JP; Sundberg BA; Beamer WG. 1997. Comparison of chemical carcinogen skin tumor induction efficacy in inbred, mutant, and hybrid strains of mice: Morphologic variations of induced tumors and absence of a papillomavirus cocarcinogen. Mol Carcinog 20(1):19-32. [PubMed: 9328433]  [MGI Ref ID J:43880]

Suzu S; Tanaka-Douzono M; Nomaguchi K; Yamada M; Hayasawa H; Kimura F; Motoyoshi K. 2000. p56(dok-2) as a cytokine-inducible inhibitor of cell proliferation and signal transduction. EMBO J 19(19):5114-22. [PubMed: 11013214]  [MGI Ref ID J:150402]

Tober KL; Thomas-Ahner JM; Kusewitt DF; Oberyszyn TM. 2007. Effects of UVB on E prostanoid receptor expression in murine skin. J Invest Dermatol 127(1):214-21. [PubMed: 16917495]  [MGI Ref ID J:116974]

Tsukahara K; Kakuo S; Moriwaki S; Hotta M; Ohuchi A; Kitahara T; Harada N. 2008. The characteristics of aromatase deficient hairless mice indicate important roles of extragonadal estrogen in the skin. J Steroid Biochem Mol Biol 108(1-2):82-90. [PubMed: 17951050]  [MGI Ref ID J:130515]

Vollmar B; Morgenthaler M; Amon M; Menger MD. 2000. Skin microvascular adaptations during maturation and aging of hairless mice Am J Physiol Heart Circ Physiol 279(4):H1591-9. [PubMed: 11009445]  [MGI Ref ID J:65226]

Wang XP; Schunck M; Kallen KJ; Neumann C; Trautwein C; Rose-John S; Proksch E. 2004. The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis. J Invest Dermatol 123(1):124-31. [PubMed: 15191552]  [MGI Ref ID J:90509]

Wilgus TA; Koki AT; Zweifel BS; Rubal PA; Oberyszyn TM. 2003. Chemotherapeutic efficacy of topical celecoxib in a murine model of ultraviolet light B-induced skin cancer. Mol Carcinog 38(1):33-9. [PubMed: 12949841]  [MGI Ref ID J:85679]

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mt-Trm2 related

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Mathews CE; Leiter EH; Spirina O; Bykhovskaya Y; Gusdon AM; Ringquist S; Fischel-Ghodsian N. 2005. mt-Nd2 Allele of the ALR/Lt mouse confers resistance against both chemically induced and autoimmune diabetes. Diabetologia 48(2):261-7. [PubMed: 15692809]  [MGI Ref ID J:97969]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Price (US dollars $)
Cryorecovery Fee $1900.00
Cryopreserved Embryos $1600.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Price (US dollars $)
Cryorecovery Fee $2470.00
Cryopreserved Embryos $2080.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

Supply Details

Standard SupplyCryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryopreserved Embryos
    This strain is also available as cryopreserved embryos. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.
  • Cryorecovery - Standard.
    We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

  • This strain is included in the Mouse Mutant Resource collection.
  • Genomic DNA is available for this strain from the Mouse DNA Resource.
Important Note
This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss that is already severe by three months of age (Johnson et al. 2000).

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Terms of Use

Terms of Use


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General inquiries

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phone:207-288-6470
fax:207-288-6655

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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