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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names NOR.NOD-(Il1-Ada)/Lt (Changed: 28-DEC-06 ) NOR.NOD-(Il1-D2Mit144)/Lt (Changed: 25-APR-06 ) NOR.NOD-Il1 (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain NOR/Lt Donor Strain NOD/ShiLt H2 Haplotype g7 Generation ?+F1p
Generation DefinitionsDonating Investigator Edward Leiter, The Jackson Laboratory Appearance
albino
Related Genotype: Tyrc/TyrcDescription
This NOR/Lt congenic strain is carrying alleles derived from strain NOD/Lt for interleukin 1a (Il1aNOD), adenosine deaminase (Ada) and insulin dependent diabetes susceptibility 13 (Idd13NOD) loci. Neither males nor females from this congenic strain when aged to 40 weeks showed diabetes development. This strain is useful for dissecting the role of non-MHC susceptibility genes in autoimmune diabetes.Development
The congenic stock NOR.NOD-(Il1-Ada)/Lt, carrying a defined segment of Chr 2 that includes the NOD/Lt insulin dependent diabetes susceptibility locus Idd13 (71cM), was produced by mating mice from NOR/Lt to NOD/Lt followed by crossing 20 times to NOR/Lt with selection of NOD Il1 (94cM) genotype at each generation. An additional genome wide scan verified NOR homozygosity at all other chromosomal regions known to differ between NOD/Lt and NOR/Lt. This congenic strain retains NOR/Lt genome from D2Mit277 (69.0cM) through D2Mit395 (66.9cM) . The Il1-Ada region of Chr 2 in NOR/Lt was originally derived from the C57BL/6 contribution to strain C57BLKS/J; thus, this congenic strain retains B6 alleles for the microsatellite markers D2Mit277 through D2Mit395, including the functional gene B2m (69.0cM) (Reifsnyder et al, 2005). In 2006, the T1DR received this strain at N21F28.
Control Information
| Control | ||
|---|---|---|
| 001976 NOD/ShiLtJ | (approximate) | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Idd13NOD/ShiLt allele
003064 B6.NOD-(D2Mit274-D2Mit343)/J View Strains carrying Idd13NOD/ShiLt (1 strain)
003265 FVB;129-Adatm1Mw Tg(PLADA)4118Rkmb/J 003297 FVB;129-Adatm1Mw Tg(PLFSADA)2465Rkmb/J 002346 NOD.NOR-(D2Mit490-Ada)/LtJ 002493 STOCK Adatm1Mw/J
003064 B6.NOD-(D2Mit274-D2Mit343)/J 002346 NOD.NOR-(D2Mit490-Ada)/LtJ 003051 NOD.NOR-(Il1a-Pcna)/LtJ 003050 NOD.NOR-(Zfp106-Il1a)/LtJ
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Idd13NOD/ShiLt relatedDiabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains
NOD/ShiLtJ Non-MHC Congenics
Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains
NOD/ShiLtJ MHC Congenics
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Genes & Alleles
Gene & Allele Information provided by MGI
| Gene Symbol and Name | Il1, interleukin 1 complex | ||
|---|---|---|---|
| Chromosome | 2 | ||
| Gene Common Name(s) | Il-1; | ||
| Gene Symbol and Name | Ada, adenosine deaminase | ||
| Chromosome | 2 | ||
| Allele Symbol | Idd13NOD/ShiLt | ||
| Allele Name | NOD/ShiLt | ||
| Allele Type | QTL | ||
| Strain of Origin | NOD/ShiLt | ||
| Gene Symbol and Name | Idd13, insulin dependent diabetes susceptibility 13 | ||
| Chromosome | 2 | ||
References
References provided by MGI
Selected Reference(s)
Reifsnyder PC; Li R; Silveira PA; Churchill G; Serreze DV; Leiter EH. 2005. Conditioning the genome identifies additional diabetes resistance loci in Type I diabetes resistant NOR/Lt mice. Genes Immun 6(6):528-38. [PubMed: 16015371] [MGI Ref ID J:100365]
Additional References
Idd13NOD/ShiLt relatedMatsuki N; Stanic AK; Embers ME; Van Kaer L; Morel L; Joyce S. 2003. Genetic dissection of V alpha 14J alpha 18 natural T cell number and function in autoimmune-prone mice. J Immunol 170(11):5429-37. [PubMed: 12759418] [MGI Ref ID J:85823]
Serreze DV; Prochazka M; Reifsnyder PC; Bridgett MM; Leiter EH. 1994. Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene. J Exp Med 180(4):1553-8. [PubMed: 7931087] [MGI Ref ID J:20685]
Zekavat G; Mozaffari R; Arias VJ; Rostami SY; Badkerhanian A; Tenner AJ; Nichols KE; Naji A; Noorchashm H. 2010. A novel CD93 polymorphism in non-obese diabetic (NOD) and NZB/W F1 mice is linked to a CD4+ iNKT cell deficient state. Immunogenetics 62(6):397-407. [PubMed: 20387063] [MGI Ref ID J:160373]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $1980.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2574.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
General Supply Notes
- This strain is included in the Type 1 Diabetes Repository collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 001976 NOD/ShiLtJ | (approximate) | |
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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JAX® Mice, Products & Services Conditions of Use
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