Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names Svl    (Changed: 15-DEC-04 ) Type Mutant Stock; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse

Appearance
black, cataract
Related Genotype: a/a Mip^Cat-Fr/Mip^Cat-Fr

Development
This spontaneous mutation arose on the A/J strain in 1962 (Fraser FC, et al 1962). The history of the strain background is unclear, however, it is likely that it included Swiss Webster and C57BL/6 in addition to A/J. The Jackson Laboratory imported this colony in 1993. At The Jackson Laboratory, homozygotes initally were crossed to C57BL/6J, the colony was then maintained by sibling matings. A second outcross to C57BL/6J was made to improve breeding performance.

Control Information

	Control
	None Available
Considerations for Choosing Controls

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI

	Major Intrinsic Protein of Lens Fiber; MIP - Models with phenotypic similarity to human disease where etiologies involve orthologs.1
	Cataract, Autosomal Dominant - Models with phenotypic similarity to human disease where etiologies involve orthologs.1

1 Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

Mip^Cat-Fr/Mip^Cat-Fr

        involves: A/J

• vision/eye phenotype
• abnormal lens fiber morphology
  • the main lens fiber mass degenerates   (MGI Ref ID J:5114)
  • the epithelial cells form multiple layers of atypical cells   (MGI Ref ID J:5114)
  • at 14 days of gestation, the centrally located nuclei of the lens fibers are seen to be abnormally small and dark with indistinct nucleoli   (MGI Ref ID J:5104)
  • nuclear degeneration is followed by swelling and vacuolization of the lens fibers   (MGI Ref ID J:5104)
  • by electron microscopy, changes can be seen in the nuclear envelope of the primary lens fibers in 12-day embryos   (MGI Ref ID J:30791)
• cataracts
  • lens opacities are visible when the eyes first open at 14 days   (MGI Ref ID J:5114)
• small lens   (MGI Ref ID J:5114)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Mip^Cat-Fr related

Sensorineural Research
Cataracts
      nuclear
Eye Defects

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		MipCat-Fr
Allele Name		dominant cataract Fraser
Allele Type		Spontaneous
Common Name(s)		Cat60; Svl; shrivelled;
Strain of Origin		A/J
Gene Symbol and Name		Mip, major intrinsic protein of eye lens fiber
Chromosome		10
Gene Common Name(s)		AQP0; Cat; Hfi; LIM1; Lop; MIP26; MP26; Svl; aquaporin 0; dominant cataract; hydropic fibers; lens opacity; shrivelled;
General Note		In chimeric embryos formed between a strain of mice homozygous for MipCat-Fr and the DBA/2 strain, homozygous for the wild-type Mip allele, the lens is histologically, cellularly, and biochemically normal (J:35863).A study of the lens crystallins shows a decrease in the proportion of a-crystallins and an increase in the proportion of a-crystallins (J:6987). At birth, a-crystallin mRNAs are present in nearly normal amounts and functional capacity but are selectively lost by 40 days of age. The effect is more severe in homozygotes than in heterozygotes. The a-crystallin cellular DNA does not differ from normal (J:7668).
Molecular Note		A transposon-induced error in splicing introduces a long terminal repeat sequence replacing the normal carboxy terminus in mutant mice. [MGI Ref ID J:31574]

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Muggleton-Harris AL; Festing MF; Hall M. 1987. A gene location for the inheritance of the cataract Fraser (CatFr) mouse congenital cataract. Genet Res 49(3):235-8. [PubMed: 3623098]  [MGI Ref ID J:8821]

Shiels A; Bassnett S. 1996. Mutations in the founder of the MIP gene family underlie cataract development in the mouse. Nat Genet 12(2):212-5. [PubMed: 8563764]  [MGI Ref ID J:31574]

Verrusio AC; Fraser FC. 1966. Identity of mutant genes 'Shrivelled' and cataracta congenita subcapsularis in the mouse. Genet Res 8(3):377-8. [PubMed: 5980123]  [MGI Ref ID J:5045]

Mip^Cat-Fr related

Garber AT; Stirk L; Gold RJ. 1983. Abnormalities of crystallins in the lens of the CatFraser mouse. Exp Eye Res 36(2):165-9. [PubMed: 6825736]  [MGI Ref ID J:6987]

Garber AT; Winkler C; Shinohara T; King CR; Inana G; Piatigorsky J; Gold RJ. 1985. Selective loss of a family of gene transcripts in a hereditary murine cataract. Science 227(4682):74-7. [PubMed: 3964960]  [MGI Ref ID J:7668]

Koniukhov BV; Kolesova NA. 1976. [Ultrastructural analysis of the effects of dominant cataract-Fr gene in mouse embryos] Ontogenez 7(3):271-7. [PubMed: 1026873]  [MGI Ref ID J:30791]

Muggleton-Harris AL; Festing MF; Hall M. 1987. A gene location for the inheritance of the cataract Fraser (CatFr) mouse congenital cataract. Genet Res 49(3):235-8. [PubMed: 3623098]  [MGI Ref ID J:8821]

Muggleton-Harris AL; Hardy K; Higbee N. 1987. Rescue of developmental lens abnormalities in chimaeras of noncataractous and congenital cataractous mice. Development 99(4):473-80. [PubMed: 3665766]  [MGI Ref ID J:35863]

Shiels A; Bassnett S. 1996. Mutations in the founder of the MIP gene family underlie cataract development in the mouse. Nat Genet 12(2):212-5. [PubMed: 8563764]  [MGI Ref ID J:31574]

Shiels A; Mackay D; Bassnett S; Al-Ghoul K; Kuszak J. 2000. Disruption of lens fiber cell architecture in mice expressing a chimeric AQP0-LTR protein. FASEB J 14(14):2207-12. [PubMed: 11053241]  [MGI Ref ID J:118920]

Verrusio AC; Fraser FC. 1966. Identity of mutant genes 'Shrivelled' and cataracta congenita subcapsularis in the mouse. Genet Res 8(3):377-8. [PubMed: 5980123]  [MGI Ref ID J:5045]

Verrusio C. 1964. Shrivelled allele of Cat Mouse News Lett 31:35.  [MGI Ref ID J:202]

Zwaan J; Williams RM. 1969. Cataracts and abnormal proliferation of the lens epithelium in mice carrying the CatFr gene. Exp Eye Res 8(2):161-7. [PubMed: 5786866]  [MGI Ref ID J:5114]

Zwaan J; Williams RM. 1968. Morphogenesis of the eye lens in a mouse strain with hereditary cataracts. J Exp Zool 169(4):407-21. [PubMed: 5716581]  [MGI Ref ID J:5104]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.

Purchasing information

Pricing, Supply Level & Notes, Controls

General Supply Notes

• This strain is included in the Eye Mutant Resource within the Mouse Mutant Resource collection.

Control Information

	Control
	None Available
Considerations for Choosing Controls
Control Pricing Information for Genetically Engineered Mutant Strains.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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