Strain Name:

FVB/N-Tg(MMTV-PyVT)634Mul/J

Stock Number:

002374

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Availability:

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Use Restrictions Apply, see Terms of Use
Common Names: MMTV-PyMT;    
MMTV-PyMT females develop palpable mammary tumors which metastasize to the lung. Male carriers also develop mammary tumors with a later age of onset. MMTV-PyVT transgenic mice express the Polyoma Virus middle T antigen under the direction of the mouse mammary tumor virus promoter/enhancer.

Description

Strain Information

Former Names FVB/N-Tg(MMTVPyVT)634Mul/J    (Changed: 15-DEC-04 )
Type Coisogenic; Mutant Strain; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemNoncarrier x Hemizygote         (Female x Male)   05-APR-08
Specieslaboratory mouse
GenerationN18+F13 (28-JUN-13)
Generation Definitions
 
Donating InvestigatorDr. William Muller,   McGill University

Appearance
albino
Related Genotype: Tyrc/Tyrc

Important Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.

Description
The MMTV-PyVT transgene (MMTV-PyMT) has the mouse mammary tumor virus (MMTV) long terminal repeat upstream of a cDNA sequence encoding the Polyoma Virus middle T antigen (PyVT). Transgenic mice are viable, but show loss of lactational ability coincident with transgene expression. Female carriers develop palpable mammary tumors as early as 5 weeks of age. Adenocarcinomas arise in virgin and breeder females as well as males, which are multifocal, highly fibrotic, and involve the entire mammary fat pad. Males also develop adenocarcinoma of the seminal vesicles and hemangiomas. Pulmonary metastases are observed in 80-94% of tumor-bearing female mice. Transgene expression is detected at high levels in male and female mammary glands. Lower levels are detected in salivary gland, seminal vesicles, ovaries, and lungs (believed to be the result of pulmonary metastases).

Development
To derive the MMTV-PyVT transgene (MMTV-PyMT), cDNA encoding the Polyoma Virus middle T antigen was inserted into the expression vector, pMMTV-SV40, resulting in a fusion gene of the PyVT oncogene and SV40 poly A and 3' processing signals, driven by the Mouse Mammary Tumor Virus (MMTV) LTR. Construct DNA was injected into the pronuclei of FVB/N zygotes. Transgenic progeny were identified by Southern blot analysis using a PyVT cDNA probe. Seven founder lines were established; this is line #634.

Control Information

  Control
   Noncarrier
   001800 FVB/NJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tg(MMTV-PyVT)634Mul allele
022974   B6.FVB-Tg(MMTV-PyVT)634Mul/LellJ
View Strains carrying   Tg(MMTV-PyVT)634Mul     (1 strain)

View Strains carrying other alleles of MMTV     (18 strains)

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data
Mouse Phenome Database
View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Characteristics of this human disease are associated with transgenes and other mutation types in the mouse.
Breast Cancer
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tg(MMTV-PyVT)634Mul/0

        FVB/N-Tg(MMTV-PyVT)634Mul
  • tumorigenesis
  • increased mammary adenocarcinoma incidence   (MGI Ref ID J:48285)
    • mammary tumors appear in males and females with 100% penetrance by 40 days of age   (MGI Ref ID J:51424)
    • all female carriers develop palpable mammary tumors by 5 weeks of age; male carriers also develop these tumors with a later age of onset (median 83 days of age)   (MGI Ref ID J:46460)
    • tumors are multifocal, highly fibrotic, and involved the entire mammary fat pad   (MGI Ref ID J:46460)
  • increased metastatic potential   (MGI Ref ID J:48285)
    • pulmonary metastases are observed in 94% of tumor-bearing female mice and 80% of tumor-bearing male mice   (MGI Ref ID J:46460)
  • endocrine/exocrine gland phenotype
  • abnormal lactation
    • inability to lactate from the time of the first pregnancy   (MGI Ref ID J:46460)
  • integument phenotype
  • abnormal lactation
    • inability to lactate from the time of the first pregnancy   (MGI Ref ID J:46460)

Tg(MMTV-PyVT)634Mul/0

        FVB/N-Tg(MMTV-PyVT)634Mul/J
  • tumorigenesis
  • altered tumor morphology
    • metastatic lung tumors exhibit more blood vessel staining compared with equivalent tumors in Mmp9tm1Tvu/Mmp9tm1Tvu Tg(MMTV-PyVT)634Mul mice   (MGI Ref ID J:140033)
    • increased tumor growth/size
      • proliferation and apoptosis of tumor cells are increased compared with cells from Mmp9tm1Tvu/Mmp9tm1Tvu Tg(MMTV-PyVT)634Mul mice with the balance resulting in increased tumor size   (MGI Ref ID J:140033)
  • increased mammary gland tumor incidence   (MGI Ref ID J:140033)
    • mice develop mammary gland tumors with a median age of tumor latency of 66 days in females and 133.5 days in males unlike wild-type mice   (MGI Ref ID J:147458)
  • respiratory system phenotype
  • increased lung weight   (MGI Ref ID J:147458)

Tg(MMTV-PyVT)634Mul/0

        involves: FVB/N
  • tumorigenesis
  • increased mammary gland tumor incidence
    • average onset of tumor development is 66 days   (MGI Ref ID J:133325)
    • tumor nodules are present throughout the entire mammary gland   (MGI Ref ID J:133325)
    • extensive adenomas are found   (MGI Ref ID J:133325)
  • endocrine/exocrine gland phenotype
  • abnormal mammary gland morphology
    • tumor nodules are present throughout the entire mammary gland   (MGI Ref ID J:133325)
  • integument phenotype
  • abnormal mammary gland morphology
    • tumor nodules are present throughout the entire mammary gland   (MGI Ref ID J:133325)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tg(MMTV-PyVT)634Mul/0

        multiple strains
  • tumorigenesis
  • decreased mammary gland tumor incidence
    • in F1 FVB/N mice crossed to the P/J, DBA/1J, NZW/LacJ, C57BL/6NIcr, CAST/Ei, NOD/LtJ, CBA/CaJ, SWR/J, AKR/J, BUB/BnJ, ST/J, KK/HiJ, or MOLF/Ei strains, an increased latency of the onset of the appearance of primary mammary tumors is seen compared to the inbred FVB/N strain   (MGI Ref ID J:48854)
  • decreased metastatic potential
    • in F1 FVB/N mice crossed to the RF/J, C58/J, C57BR/cdJ, NZB/B1NJ, I/LnJ, DBA/2J, KK/HiJ, MOLF/Ei, SEA/GnJ, NZW/LacJ, or CE/J strains, an decrease in pulmonary metastatic index is seen   (MGI Ref ID J:48854)
  • increased mammary adenocarcinoma incidence
    • in F1 FVB/N mice crossed to either the I/LnJ or C58/J strains, an acceleration of the onset of the appearance of primary mammary tumors is seen compared to the inbred FVB/N strain   (MGI Ref ID J:48854)
  • increased metastatic potential
    • in F1 FVB/N mice crossed to the AKR/J strain, an increase in pulmonary metastatic index is seen   (MGI Ref ID J:48854)

Tg(MMTV-PyVT)634Mul/0

        involves: 129 * C57BL/6 * FVB/N
  • tumorigenesis
  • increased mammary adenocarcinoma incidence
    • all female virgin mice develop cancer tumors in the breast by 14 weeks of age   (MGI Ref ID J:117336)

Tg(MMTV-PyVT)634Mul/0

        involves: C57BL/6 * FVB/N
  • tumorigenesis
  • increased mammary gland tumor incidence
    • mice develop mammary gland tumors with a median age of tumor latency of 73 days in females and 137 days in males unlike wild-type mice   (MGI Ref ID J:147458)
  • respiratory system phenotype
  • increased lung weight   (MGI Ref ID J:147458)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cancer Research
Increased Tumor Incidence
      Gonadal Tumors
      Mammary Gland Tumors
      Other Tissues/Organs
Other
      tumor metastasis

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(MMTV-PyVT)634Mul
Allele Name transgene insertion 634, William Muller
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) MMTV-PyMT; MMTV-PyVmT; MT634; MTAG; PyMT; PyV-mT; PyVT; Tg(MMTVPyVT)634Mul; TgN(MMTVPyVT)634Mul;
Mutation Made ByDr. William Muller,   McGill University
Strain of OriginFVB/N
Expressed Gene PyVT, Polyoma virus middle T antigen, polyoma virus
Promoter MMTV, Mouse Mammary Tumor Virus, MMTV
General Note Additional lines produced include lines 121, 196, 235, 654, 668, 670.

These mice are used to study metastatic disease.

Molecular Note This transgene expresses polyoma virus middle T antigen under the control of the mouse mammary tumor virus LTR. Expression of this transgene was detected at high levels in male and female mammary glands. Other expression sites include salivary gland, seminal vesicles, ovaries, and lung. [MGI Ref ID J:46460]
 
 
 
Allele Symbol Pde6brd1
Allele Name retinal degeneration 1
Allele Type Spontaneous
Common Name(s) Pdebrd1; rd; rd-1; rd1; rodless retina;

Genotyping

Genotyping Information

Genotyping Protocols

Tg(MMTV-PyVT)634Mul, High Resolution Melting
Tg(MMTV-PyVT)634Mul, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Guy CT; Cardiff RD; Muller WJ. 1992. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol 12(3):954-61. [PubMed: 1312220]  [MGI Ref ID J:46460]

Additional References

Le Voyer T; Rouse J; Lu Z; Lifsted T; Williams M; Hunter KW. 2001. Three loci modify growth of a transgene-induced mammary tumor: suppression of proliferation associated with decreased microvessel density. Genomics 74(3):253-61. [PubMed: 11414753]  [MGI Ref ID J:70229]

Muraoka RS; Dumont N; Ritter CA; Dugger TC; Brantley DM; Chen J; Easterly E; Roebuck LR; Ryan S; Gotwals PJ; Koteliansky V; Arteaga CL. 2002. Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest 109(12):1551-9. [PubMed: 12070302]  [MGI Ref ID J:86709]

Politi K; Kljuic A; Szabolcs M; Fisher P; Ludwig T; Efstratiadis A. 2004. 'Designer' tumors in mice. Oncogene 23(8):1558-65. [PubMed: 14661057]  [MGI Ref ID J:87544]

Saez E; Rosenfeld J; Livolsi A; Olson P; Lombardo E; Nelson M; Banayo E; Cardiff RD; Izpisua-Belmonte JC; Evans RM. 2004. PPAR gamma signaling exacerbates mammary gland tumor development. Genes Dev 18(5):528-40. [PubMed: 15037548]  [MGI Ref ID J:89019]

Tg(MMTV-PyVT)634Mul related

Ahn R; Sabourin V; Ha JR; Cory S; Maric G; Im YK; Hardy WR; Zhao H; Park M; Hallett M; Siegel PM; Pawson T; Ursini-Siegel J. 2013. The ShcA PTB Domain Functions as a Biological Sensor of Phosphotyrosine Signaling during Breast Cancer Progression. Cancer Res 73(14):4521-32. [PubMed: 23695548]  [MGI Ref ID J:199117]

Al Masri A; Gendler SJ. 2005. Muc1 affects c-Src signaling in PyV MT-induced mammary tumorigenesis. Oncogene 24(38):5799-808. [PubMed: 15897873]  [MGI Ref ID J:101766]

Albright CD; Salganik RI; Van Dyke T. 2004. Dietary depletion of vitamin e and vitamin a inhibits mammary tumor growth and metastasis in transgenic mice. J Nutr 134(5):1139-44. [PubMed: 15113960]  [MGI Ref ID J:90173]

Almholt K; Juncker-Jensen A; Laerum OD; Dano K; Johnsen M; Lund LR; Romer J. 2008. Metastasis is strongly reduced by the matrix metalloproteinase inhibitor Galardin in the MMTV-PymT transgenic breast cancer model. Mol Cancer Ther 7(9):2758-67. [PubMed: 18790756]  [MGI Ref ID J:152124]

Almholt K; Lund LR; Rygaard J; Nielsen BS; Dano K; Romer J; Johnsen M. 2005. Reduced metastasis of transgenic mammary cancer in urokinase-deficient mice. Int J Cancer 113(4):525-32. [PubMed: 15472905]  [MGI Ref ID J:94645]

Asrani K; Keri RA; Galisteo R; Brown SA; Morgan SJ; Ghosh A; Tran NL; Winkles JA. 2013. The HER2- and heregulin beta1 (HRG)-inducible TNFR superfamily member Fn14 promotes HRG-driven breast cancer cell migration, invasion, and MMP9 expression. Mol Cancer Res 11(4):393-404. [PubMed: 23378579]  [MGI Ref ID J:205464]

Asselin-Labat ML; Sutherland KD; Vaillant F; Gyorki DE; Wu D; Holroyd S; Breslin K; Ward T; Shi W; Bath ML; Deb S; Fox SB; Smyth GK; Lindeman GJ; Visvader JE. 2011. Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14. Mol Cell Biol 31(22):4609-22. [PubMed: 21930782]  [MGI Ref ID J:178780]

Bachawal SV; Jensen KC; Lutz AM; Gambhir SS; Tranquart F; Tian L; Willmann JK. 2013. Earlier detection of breast cancer with ultrasound molecular imaging in a transgenic mouse model. Cancer Res 73(6):1689-98. [PubMed: 23328585]  [MGI Ref ID J:196899]

Balboni AL; Hutchinson JA; DeCastro AJ; Cherukuri P; Liby K; Sporn MB; Schwartz GN; Wells WA; Sempere LF; Yu PB; DiRenzo J. 2013. DeltaNp63alpha-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells. Cancer Res 73(2):1020-30. [PubMed: 23243027]  [MGI Ref ID J:194364]

Basu GD; Pathangey LB; Tinder TL; Lagioia M; Gendler SJ; Mukherjee P. 2004. Cyclooxygenase-2 inhibitor induces apoptosis in breast cancer cells in an in vivo model of spontaneous metastatic breast cancer. Mol Cancer Res 2(11):632-42. [PubMed: 15561779]  [MGI Ref ID J:94659]

Basu GD; Tinder TL; Bradley JM; Tu T; Hattrup CL; Pockaj BA; Mukherjee P. 2006. Cyclooxygenase-2 inhibitor enhances the efficacy of a breast cancer vaccine: role of IDO. J Immunol 177(4):2391-402. [PubMed: 16888001]  [MGI Ref ID J:138387]

Bentires-Alj M; Neel BG. 2007. Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer. Cancer Res 67(6):2420-4. [PubMed: 17347513]  [MGI Ref ID J:120339]

Berger T; Cheung CC; Elia AJ; Mak TW. 2010. Disruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasis. Proc Natl Acad Sci U S A 107(7):2995-3000. [PubMed: 20133630]  [MGI Ref ID J:157568]

Berger T; Ueda T; Arpaia E; Chio II; Shirdel EA; Jurisica I; Hamada K; You-Ten A; Haight J; Wakeham A; Cheung CC; Mak TW. 2013. Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model. Oncogene 32(41):4989-94. [PubMed: 23146906]  [MGI Ref ID J:203238]

Bierie B; Stover DG; Abel TW; Chytil A; Gorska AE; Aakre M; Forrester E; Yang L; Wagner KU; Moses HL. 2008. Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment. Cancer Res 68(6):1809-19. [PubMed: 18339861]  [MGI Ref ID J:133311]

Bist P; Leow SC; Phua QH; Shu S; Zhuang Q; Loh WT; Nguyen TH; Zhou JB; Hooi SC; Lim LH. 2011. Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-kappaB: implication in breast cancer metastasis. Oncogene 30(28):3174-85. [PubMed: 21383699]  [MGI Ref ID J:174635]

Brantley-Sieders DM; Zhuang G; Hicks D; Fang WB; Hwang Y; Cates JM; Coffman K; Jackson D; Bruckheimer E; Muraoka-Cook RS; Chen J. 2008. The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling. J Clin Invest 118(1):64-78. [PubMed: 18079969]  [MGI Ref ID J:130805]

Braumuller H; Wieder T; Brenner E; Assmann S; Hahn M; Alkhaled M; Schilbach K; Essmann F; Kneilling M; Griessinger C; Ranta F; Ullrich S; Mocikat R; Braungart K; Mehra T; Fehrenbacher B; Berdel J; Niessner H; Meier F; van den Broek M; Haring HU; Handgretinger R; Quintanilla-Martinez L; Fend F; Pesic M; Bauer J; Zender L; Schaller M; Schulze-Osthoff K; Rocken M. 2013. T-helper-1-cell cytokines drive cancer into senescence. Nature 494(7437):361-5. [PubMed: 23376950]  [MGI Ref ID J:194546]

Bu W; Chen J; Morrison GD; Huang S; Creighton CJ; Huang J; Chamness GC; Hilsenbeck SG; Roop DR; Leavitt AD; Li Y. 2011. Keratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer. Oncogene 30(43):4399-409. [PubMed: 21532625]  [MGI Ref ID J:178580]

Bugge TH; Lund LR; Kombrinck KK; Nielsen BS; Holmback K; Drew AF; Flick MJ; Witte DP; Dano K; Degen JL. 1998. Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice. Oncogene 16(24):3097-104. [PubMed: 9671388]  [MGI Ref ID J:48285]

Butinar M; Prebanda MT; Rajkovic J; Jeric B; Stoka V; Peters C; Reinheckel T; Kruger A; Turk V; Turk B; Vasiljeva O. 2014. Stefin B deficiency reduces tumor growth via sensitization of tumor cells to oxidative stress in a breast cancer model. Oncogene 33(26):3392-400. [PubMed: 23955077]  [MGI Ref ID J:212612]

Cao Y; Luo JL; Karin M. 2007. IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells. Proc Natl Acad Sci U S A 104(40):15852-7. [PubMed: 17890319]  [MGI Ref ID J:125555]

Chen P; O'Neal JF; Ebelt ND; Cantrell MA; Mitra S; Nasrazadani A; Vandenbroek TL; Heasley LE; Van Den Berg CL. 2010. Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model. PLoS One 5(5):e10443. [PubMed: 20454618]  [MGI Ref ID J:160923]

Cheng AM; Saxton TM; Sakai R; Kulkarni S; Mbamalu G; Vogel W; Tortorice CG; Cardiff RD; Cross JC; Muller WJ; Pawson T. 1998. Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cell 95(6):793-803. [PubMed: 9865697]  [MGI Ref ID J:51424]

Cheung KJ; Gabrielson E; Werb Z; Ewald AJ. 2013. Collective invasion in breast cancer requires a conserved basal epithelial program. Cell 155(7):1639-51. [PubMed: 24332913]  [MGI Ref ID J:205494]

Clark-Knowles KV; Dewar-Darch D; Jardine KE; McBurney MW. 2013. SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer. PLoS One 8(11):e82106. [PubMed: 24278473]  [MGI Ref ID J:209772]

Cook RS; Jacobsen KM; Wofford AM; DeRyckere D; Stanford J; Prieto AL; Redente E; Sandahl M; Hunter DM; Strunk KE; Graham DK; Earp HS 3rd. 2013. MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis. J Clin Invest 123(8):3231-42. [PubMed: 23867499]  [MGI Ref ID J:201406]

Coombs GS; Schmitt AA; Canning CA; Alok A; Low IC; Banerjee N; Kaur S; Utomo V; Jones CM; Pervaiz S; Toone EJ; Virshup DM. 2012. Modulation of Wnt/beta-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer. Oncogene 31(2):213-25. [PubMed: 21666721]  [MGI Ref ID J:179415]

Cozma D; Lukes L; Rouse J; Qiu TH; Liu ET; Hunter KW. 2002. A bioinformatics-based strategy identifies c-Myc and Cdc25A as candidates for the Apmt mammary tumor latency modifiers. Genome Res 12(6):969-75. [PubMed: 12045150]  [MGI Ref ID J:77063]

Cramer EP; Glenthoj A; Hager M; Juncker-Jensen A; Engelholm LH; Santoni-Rugiu E; Lund LR; Laerum OD; Cowland JB; Borregaard N. 2012. No effect of NGAL/lipocalin-2 on aggressiveness of cancer in the MMTV-PyMT/FVB/N mouse model for breast cancer. PLoS One 7(6):e39646. [PubMed: 22737251]  [MGI Ref ID J:187808]

Cuevas BD; Winter-Vann AM; Johnson NL; Johnson GL. 2006. MEKK1 controls matrix degradation and tumor cell dissemination during metastasis of polyoma middle-T driven mammary cancer. Oncogene 25(36):4998-5010. [PubMed: 16568086]  [MGI Ref ID J:112298]

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Dai L; Guinea MC; Slomiany MG; Bratoeva M; Grass GD; Tolliver LB; Maria BL; Toole BP. 2013. CD147-Dependent Heterogeneity in Malignant and Chemoresistant Properties of Cancer Cells. Am J Pathol 182(2):577-85. [PubMed: 23178078]  [MGI Ref ID J:192310]

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De Palma M; Mazzieri R; Politi LS; Pucci F; Zonari E; Sitia G; Mazzoleni S; Moi D; Venneri MA; Indraccolo S; Falini A; Guidotti LG; Galli R; Naldini L. 2008. Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis. Cancer Cell 14(4):299-311. [PubMed: 18835032]  [MGI Ref ID J:140090]

DeNardo DG; Barreto JB; Andreu P; Vasquez L; Tawfik D; Kolhatkar N; Coussens LM. 2009. CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 16(2):91-102. [PubMed: 19647220]  [MGI Ref ID J:151976]

Deeb KK; Michalowska AM; Yoon CY; Krummey SM; Hoenerhoff MJ; Kavanaugh C; Li MC; Demayo FJ; Linnoila I; Deng CX; Lee EY; Medina D; Shih JH; Green JE. 2007. Identification of an Integrated SV40 T/t-Antigen Cancer Signature in Aggressive Human Breast, Prostate, and Lung Carcinomas with Poor Prognosis. Cancer Res 67(17):8065-8080. [PubMed: 17804718]  [MGI Ref ID J:124885]

Dong D; Ni M; Li J; Xiong S; Ye W; Virrey JJ; Mao C; Ye R; Wang M; Pen L; Dubeau L; Groshen S; Hofman FM; Lee AS. 2008. Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development. Cancer Res 68(2):498-505. [PubMed: 18199545]  [MGI Ref ID J:131417]

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Ellies LG. 2003. PyV-mT-induced parotid gland hyperplasia as detected by altered lectin reactivity is not modulated by inducible nitric oxide deficiency. Arch Oral Biol 48(6):415-22. [PubMed: 12749913]  [MGI Ref ID J:84218]

Ellies LG; Fishman M; Hardison J; Kleeman J; Maglione JE; Manner CK; Cardiff RD; MacLeod CL. 2003. Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase. Int J Cancer 106(1):1-7. [PubMed: 12794750]  [MGI Ref ID J:84004]

Emtage PC; Wan Y; Hitt M; Graham FL; Muller WJ; Zlotnik A; Gauldie J. 1999. Adenoviral vectors expressing lymphotactin and interleukin 2 or lymphotactin and interleukin 12 synergize to facilitate tumor regression in murine breast cancer models [see comments] Hum Gene Ther 10(5):697-709. [PubMed: 10210138]  [MGI Ref ID J:54403]

Esteva-Font C; Jin BJ; Verkman AS. 2014. Aquaporin-1 gene deletion reduces breast tumor growth and lung metastasis in tumor-producing MMTV-PyVT mice. FASEB J 28(3):1446-53. [PubMed: 24334548]  [MGI Ref ID J:210686]

Eubank TD ; Roberts RD ; Khan M ; Curry JM ; Nuovo GJ ; Kuppusamy P ; Marsh CB. 2009. Granulocyte macrophage colony-stimulating factor inhibits breast cancer growth and metastasis by invoking an anti-angiogenic program in tumor-educated macrophages. Cancer Res 69(5):2133-40. [PubMed: 19223554]  [MGI Ref ID J:146607]

Eyob H; Ekiz HA; Derose YS; Waltz SE; Williams MA; Welm AL. 2013. Inhibition of ron kinase blocks conversion of micrometastases to overt metastases by boosting antitumor immunity. Cancer Discov 3(7):751-60. [PubMed: 23612011]  [MGI Ref ID J:203569]

Fan H; Zhao X; Sun S; Luo M; Guan JL. 2013. Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo. J Biol Chem 288(5):3322-33. [PubMed: 23255596]  [MGI Ref ID J:195658]

Fantozzi A; Christofori G. 2006. Mouse models of breast cancer metastasis. Breast Cancer Res 8(4):212. [PubMed: 16887003]  [MGI Ref ID J:116013]

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Wyckoff JB; Wang Y; Lin EY; Li JF; Goswami S; Stanley ER; Segall JE; Pollard JW; Condeelis J. 2007. Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res 67(6):2649-56. [PubMed: 17363585]  [MGI Ref ID J:120318]

Xiao G; Deng A; Liu H; Ge G; Liu X. 2012. Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1. Proc Natl Acad Sci U S A 109(38):15419-24. [PubMed: 22949674]  [MGI Ref ID J:190150]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, FVB/NJ inbred females (Stock No. 001800) may be bred with hemizygous males. The expected coat color from breeding is Albino.
Mating SystemNoncarrier x Hemizygote         (Female x Male)   05-APR-08
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $232.00Female or MaleHemizygous for Tg(MMTV-PyVT)634Mul  
Price per Pair (US dollars $)Pair Genotype
$304.00Noncarrier x Hemizygous for Tg(MMTV-PyVT)634Mul  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $301.60Female or MaleHemizygous for Tg(MMTV-PyVT)634Mul  
Price per Pair (US dollars $)Pair Genotype
$395.20Noncarrier x Hemizygous for Tg(MMTV-PyVT)634Mul  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   Noncarrier
   001800 FVB/NJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Important Note

This strain is homozygous for the retinal degeneration allele Pde6brd1.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Notice to customers in Canada.
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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