Strain Name: |
FVB/N-Tg(UcpDta)1Kz/J |
|---|---|
Stock Number: |
002384 |
Availability: | Repository-Cryopreserved |
Price and Supply Information | |
General Terms and Conditions |
| Former Name |
FVB/N-Ucp(Dta) (Changed: 15-DEC-04
) |
| Genes & Alleles | Dta; Pde6b; Pde6brd1; Ucp; Tg(UcpDta)1Kz; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Mutant Strain Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Transgenic Species laboratory mouse Generation +N1 Appearance
albino
Related Genotype: Tyrc/TyrcImportant Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.Strain Description
Transgenic mice fed a "Western diet" developed marked obesity, insulin resistance, hyperglycemia, and hyperlipidemia. Mice hemizygous for the TgN(UcpDta)1Kz transgene develop early obesity in the absence of hyperphagia indicating an increased metabolic efficiency. Hyperphagia does follow and is present in mice over 7 weeks of age.Strain Development
Brown adipose tissue was genetically ablated by incorpation of a toxic transgene, dipththeria toxin A-chain, coupled to regulatory elements of the gene for the brown adipose tissue specific uncoupling protein, UCP.
Related Disease (OMIM) Terms |
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Tg(UcpDta)1Kz | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Leslie P Kozak | ||
| Common Name(s) | BATless; UCP-DTA; | ||
| Strain of Origin | FVB/N | ||
| Expressed Gene | Dta, Diphtheria toxin A chain, | ||
| Brown fat specific expression of the A-chain of diptheria toxin (DTA) resulting in ablation of brown fat. | |||
| Promoter | Ucp, mitochondrial uncoupling protein, | ||
| Molecular Note | Incorporation of a toxic transgene, diptheria toxin-A-chain (Dta), coupled to regulatory elements of the gene for brown adipose tissue specific uncoupling protein (Ucp) resulted in the ablation of brown adipose tissue (BAT). Specifically, Dta was inserted into the first exon of Ucp1 at position +120 to create the vector. [MGI Ref ID J:78211] | ||
| Allele Symbol | Pde6brd1 | ||
| Allele Name | retinal degeneration 1 | ||
| Common Name(s) | rd; rd-1; rd1; rodless retina; | ||
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 001800 FVB/NJ | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for JAX® GEMM® Strains | ||
Genotyping Protocols
Tg(UcpDta)1Kz
Colony Maintenance
| Breeding & Husbandry | Transgenic mice have micropthalamia and cataracts related to integration site. Transgenic animals can be identified at the age of 16 days. Expected coat color from breeding:Albino |
|---|---|
| Diet Information | LabDiet® 5K52/5K67 |
Related Strains
Strains carrying Pde6brd1 allele
View Strains carrying Pde6brd1 (74 strains)
006576 B6.FVB-Tg(GNAT2-Dta)98Wwk/J 008168 STOCK Tg(tetO-DTA)1Gfi/J
004297 B6.CXB1-Pde6brd10/J 002802 C3.BLiA Pde6b+-Krd/J 001979 C3A.BLiA-Pde6b+.O20-Prph2Rd2/J 001912 C3A.BLiA-Pde6b+/J 003648 C3Sn.BLiA-Pde6b+/Dn 004766 C57BL/6J-Pde6brd1-2J/J 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
002661 B6;SJL-Tg(EPO33)72Ptc/J
Research Applications
This mouse can be used to support research in many areas including:
Pde6brd1 relatedDiabetes and Obesity Research
Hyperglycemia (diet-induced)
Hyperinsulinemia (diet-induced)
Insulin Resistance (diet-induced)
Obesity With Diabetes (diet-induced)
Type 2 Diabetes (NIDDM) (diet-induced)
Metabolism Research
Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive
Sensorineural Research
Retinal Degeneration
References
Selected Reference(s)
Additional ReferencesLowell BB; S-Susulic V; Hamann A; Lawitts JA; Himms-Hagen J; Boyer BB; Kozak LP; Flier JS. 1993. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366(6457):740-2. [PubMed: 8264795] [MGI Ref ID J:78211]
Price and Supply Information
| Strain Name: | FVB/N-Tg(UcpDta)1Kz/J |
| Stock Number: | 002384 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:
- USA, Canada and Mexico
- International
*Pricing for Shipping Destination selected:
USA, Canada and Mexico
| Price(s) in US dollars ($) | |||||
|---|---|---|---|---|---|
| Cryorecovery Fee | $1900.00 | ||||
Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. View Control Pricing Information for JAX® Strains. |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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