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Strain Name:

FVB/N-Tg(UcpDta)1Kz/J

Stock Number:

002384

Availability:

Repository-Cryopreserved


Link to main datasheet for 002384

Additional References

 

Cittadini A; Mantzoros CS; Hampton TG; Travers KE; Katz SE; Morgan JP; Flier JS; Douglas PS. 1999. Cardiovascular abnormalities in transgenic mice with reduced brown fat: an animal model of human obesity. Circulation 100(21):2177-83. [PubMed: 10571977]  [MGI Ref ID J:59645]

Duncan JG; Fong JL; Medeiros DM; Finck BN; Kelly DP. 2007. Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway. Circulation 115(7):909-17. [PubMed: 17261654]  [MGI Ref ID J:130544]

Finck BN; Bernal-Mizrachi C; Han DH; Coleman T; Sambandam N; LaRiviere LL; Holloszy JO; Semenkovich CF; Kelly DP. 2005. A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes. Cell Metab 1(2):133-44. [PubMed: 16054054]  [MGI Ref ID J:129848]

Fu L; John LM; Adams SH; Yu XX; Tomlinson E; Renz M; Williams PM; Soriano R; Corpuz R; Moffat B; Vandlen R; Simmons L; Foster J; Stephan JP; Tsai SP; Stewart TA. 2004. Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes. Endocrinology 145(6):2594-603. [PubMed: 14976145]  [MGI Ref ID J:133073]

Gouon-Evans V; Pollard JW. 2002. Unexpected deposition of brown fat in mammary gland during postnatal development. Mol Endocrinol 16(11):2618-27. [PubMed: 12403850]  [MGI Ref ID J:132576]

Guerra C; Navarro P; Valverde AM; Arribas M; Bruning J; Kozak LP; Kahn CR; Benito M. 2001. Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance. J Clin Invest 108(8):1205-13. [PubMed: 11602628]  [MGI Ref ID J:72231]

Hamann A; Flier JS; Lowell BB. 1996. Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. Endocrinology 137(1):21-9. [PubMed: 8536614]  [MGI Ref ID J:100293]

Hollopeter G; Erickson JC; Palmiter RD. 1998. Role of neuropeptide Y in diet-, chemical- and genetic-induced obesity of mice. Int J Obes Relat Metab Disord 22(6):506-12. [PubMed: 9665670]  [MGI Ref ID J:49932]

Klaus S; Munzberg H; Truloff C; Heldmaier G. 1998. Physiology of transgenic mice with brown fat ablation: obesity is due to lowered body temperature. Am J Physiol 274(2 Pt 2):R287-93. [PubMed: 9486283]  [MGI Ref ID J:100346]

Mantzoros CS; Frederich RC; Qu D; Lowell BB; Maratos-Flier E; Flier JS. 1998. Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations [published erratum appears in Diabetes 1998 May;47(5):855] Diabetes 47(2):230-8. [PubMed: 9519718]  [MGI Ref ID J:45532]

Melnyk A; Himms-Hagen J. 1998. Temperature-dependent feeding: lack of role for leptin and defect in brown adipose tissue-ablated obese mice. Am J Physiol 274(4 Pt 2):R1131-5. [PubMed: 9575979]  [MGI Ref ID J:47074]

Ortmann S; Prinzler J; Klaus S. 2003. Self-selected macronutrient diet affects energy and glucose metabolism in brown fat-ablated mice. Obes Res 11(12):1536-44. [PubMed: 14694219]  [MGI Ref ID J:100331]

Siri P; Candela N; Zhang YL; Ko C; Eusufzai S; Ginsberg HN; Huang LS. 2001. Post-transcriptional Stimulation of the Assembly and Secretion of Triglyceride-rich Apolipoprotein B Lipoproteins in a Mouse with Selective Deficiency of Brown Adipose Tissue, Obesity, and Insulin Resistance. J Biol Chem 276(49):46064-72. [PubMed: 11598138]  [MGI Ref ID J:73122]

Vidal-Puig A; Jimenez-Linan M; Lowell BB; Hamann A; Hu E; Spiegelman B; Flier JS; Moller DE. 1996. Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. J Clin Invest 97(11):2553-61. [PubMed: 8647948]  [MGI Ref ID J:33358]

Zhang YL; Hernandez-Ono A; Siri P; Weisberg S; Conlon D; Graham MJ; Crooke RM; Huang LS; Ginsberg HN. 2006. Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis. J Biol Chem 281(49):37603-15. [PubMed: 16971390]  [MGI Ref ID J:117583]

 

Link to main datasheet for 002384

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