Strain Name:

B6;129S7-Fyntm1Sor/J

Stock Number:

002385

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Availability:

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Mice homozygous for Fyntm1Sor have defective T-cell receptor signaling and are characterized by a reduction in levels of tyrosine-phosphorylated proteins, failure to flux calcium in response to TCR cross-linking, and a reduction in production of calcium-related IL2.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Specieslaboratory mouse
 
Donating InvestigatorDr. Philippe Soriano,   Mount Sinai School of Medicine

Appearance
white-bellied agouti
Related Genotype: Aw/Aw

Description
Mice homozygous for the Fyntm1Sor targeted mutation are viable and fertile displaying no overt phenotype. T cell receptor signaling is defective in homozygous mutant mice and are characterized by a reduction in levels of tyrosine-phosphorylated proteins, failure to flux calcium in response to TCR cross-linking, and a reduction in production of calcium-related IL2. THY-1-induced proliferation is also reduced in thymocytes but not in splenic T cells. Neurological defects include blunted long-term potentiation (LTP), impaired special learning, and altered hippocampal development.

Control Information

  Control
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Fyntm1Sor allele
002271   129-Fyntm1Sor/J
012468   B6.129S7-Fyntm1Sor/J
View Strains carrying   Fyntm1Sor     (2 strains)

Strains carrying other alleles of Fyn
018154   B6N.129S2-Fyntm1Rmp/J
017005   FVB.Cg-Tg(KRT14-Fyn*)aJsey/J
View Strains carrying other alleles of Fyn     (2 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Fyntm1Sor/Fyntm1Sor

        either: 129S7/SvEvBrd-Fyntm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)
  • immune system phenotype
  • abnormal T cell clonal deletion
    • thymocytes are impaired in a late stage of maturation and show limited clonal deletion to the Mls-1a self-superantigen but not to staphylococcal enterotoxin A   (MGI Ref ID J:2242)
  • abnormal immune cell physiology
    • thymocytes and mature T cells fail to flux calcium to any large extent in response to TCR cross-linking   (MGI Ref ID J:2242)
    • abnormal T cell physiology
      • mature T cells fail to flux calcium to any large extent in response to TCR cross-linking   (MGI Ref ID J:2242)
      • abnormal thymocyte activation
        • proliferation of thymocytes in response to anti-CD3 or anti-Thy-1 cross-linking is substantially compromised, however peripheral T cell activation responses are largely functional   (MGI Ref ID J:2242)
      • decreased T cell proliferation
        • thymocytes of each single positive phenotype fail to proliferate in response to anti-CD3 and PMA, in contrast with single positive wild-type thymocytes   (MGI Ref ID J:2242)
    • increased IgG2a level
      • IgG2a is consistently elevated by 30-40%   (MGI Ref ID J:2242)
    • increased IgM level
      • consistently elevated by 30-40%   (MGI Ref ID J:2242)
  • decreased interleukin-2 secretion
    • production of IL-2 by splenic T cells is reduced in response to TCR activation   (MGI Ref ID J:2242)
  • behavior/neurological phenotype
  • abnormal spatial learning
    • show impaired spatial learning in Morris water maze test   (MGI Ref ID J:3417)
  • nervous system phenotype
  • abnormal dentate gyrus morphology
    • exhibit an increased number of granule cells in the dentate gyrus   (MGI Ref ID J:3417)
    • exhibit undulation of the granule cell layer   (MGI Ref ID J:3417)
  • abnormal hippocampus pyramidal cell layer
    • undulation of the pyramidal cell layer in the CA3 region and in the dentate gyrus   (MGI Ref ID J:3417)
    • abnormal hippocampus pyramidal cell morphology
      • apical dendrites of CA1 pyramidal neurons appear less tightly organized   (MGI Ref ID J:3417)
      • increased hippocampus pyramidal cell number
        • exhibit an increased number of pyramidal cells in the CA3 region   (MGI Ref ID J:3417)
  • reduced long term potentiation
    • LTP is blunted in the CA1 neurons of hippocampal slices, in both the field EPSP and in the population spike, even though synaptic transmission and two short-term forms of synaptic plasticity, paired-pulse facilitation and post-tetanic   (MGI Ref ID J:3417)
  • hematopoietic system phenotype
  • abnormal T cell clonal deletion
    • thymocytes are impaired in a late stage of maturation and show limited clonal deletion to the Mls-1a self-superantigen but not to staphylococcal enterotoxin A   (MGI Ref ID J:2242)
  • abnormal T cell physiology
    • mature T cells fail to flux calcium to any large extent in response to TCR cross-linking   (MGI Ref ID J:2242)
    • abnormal thymocyte activation
      • proliferation of thymocytes in response to anti-CD3 or anti-Thy-1 cross-linking is substantially compromised, however peripheral T cell activation responses are largely functional   (MGI Ref ID J:2242)
    • decreased T cell proliferation
      • thymocytes of each single positive phenotype fail to proliferate in response to anti-CD3 and PMA, in contrast with single positive wild-type thymocytes   (MGI Ref ID J:2242)
  • increased IgG2a level
    • IgG2a is consistently elevated by 30-40%   (MGI Ref ID J:2242)
  • increased IgM level
    • consistently elevated by 30-40%   (MGI Ref ID J:2242)
  • endocrine/exocrine gland phenotype
  • abnormal thymocyte activation
    • proliferation of thymocytes in response to anti-CD3 or anti-Thy-1 cross-linking is substantially compromised, however peripheral T cell activation responses are largely functional   (MGI Ref ID J:2242)

Fyntm1Sor/Fyntm1Sor

        involves: 129S7/SvEvBrd * C57BL/6J
  • nervous system phenotype
  • abnormal hippocampus morphology   (MGI Ref ID J:80637)
    • abnormal dentate gyrus morphology
      • abnormal arrangement of rostral dentate gyrus   (MGI Ref ID J:80637)
    • abnormal hippocampus pyramidal cell layer
      • CA1 pyramidal cells are less tightly packed   (MGI Ref ID J:80637)
      • caudal CA3 pyramidal cell regions shows an abnormal arrangement   (MGI Ref ID J:80637)
      • abnormal hippocampus pyramidal cell morphology
        • dendritic regions of pyramidal cells are narrow and length of the apical dendrites is shortened   (MGI Ref ID J:80637)
        • ectopic hippocampus pyramidal cells
          • ectopic pyramidal cells are frequently seen   (MGI Ref ID J:80637)
  • abnormal myelination
    • in the forebrain from P14 to P385, a myelin deficit is observed; at P26, deficit is 52% compared to controls   (MGI Ref ID J:109485)
    • myelin basic protein content in the brain is significantly reduced with a magnitude of 40%   (MGI Ref ID J:109485)
  • abnormal optic nerve morphology
    • there is a 15% reduction in cross-sectional area of the optic nerve compared to wild-type   (MGI Ref ID J:109485)
  • decreased corpus callosum size
    • thickness of corpus callosum is reduced compared to wild-type   (MGI Ref ID J:109485)
  • reduced long term potentiation
    • exhibit age-dependent impairment of LTP that appears only when homozygotes are over 10 weeks of age   (MGI Ref ID J:80637)
  • vision/eye phenotype
  • abnormal optic nerve morphology
    • there is a 15% reduction in cross-sectional area of the optic nerve compared to wild-type   (MGI Ref ID J:109485)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Fyntm1Sor/Fyntm1Sor

        B6.129S7-Fyntm1Sor
  • immune system phenotype
  • abnormal CD4-positive T cell physiology
    • pronounced defects in TCR-initiated proliferation and production of Ifng, IL-4 and IL-2 upon stimulation with anti-CD3 or anti-CD3 plus anti-CD28   (MGI Ref ID J:93886)
    • some responses are partially corrected by addition of exogenous IL-2, but IL-4 production block is not relieved   (MGI Ref ID J:93886)
    • cells exhibit impaired IL-4 and IL-13 production upon stimulation with anti-CD3, anti-CD3 and anti-CD28 or PMA plus ionomycin   (MGI Ref ID J:93886)
  • abnormal NK cell physiology
    • decreased killing of RMA-S, B16 and, to a lesser extent, YAC-1 cells   (MGI Ref ID J:187430)
    • reduced activating effect of 2B4 towards cytotoxicity   (MGI Ref ID J:187430)
    • reduced conjugation with RMA-S cells, less pronounced than in Sh2d1atm1Pls homozygotes   (MGI Ref ID J:187430)
  • abnormal T cell proliferation   (MGI Ref ID J:93886)
  • decreased IgE level
    • levels are dramatically reduced   (MGI Ref ID J:93886)
  • decreased interferon-gamma secretion
    • in response to RMA-S   (MGI Ref ID J:187430)
  • hematopoietic system phenotype
  • abnormal CD4-positive T cell physiology
    • pronounced defects in TCR-initiated proliferation and production of Ifng, IL-4 and IL-2 upon stimulation with anti-CD3 or anti-CD3 plus anti-CD28   (MGI Ref ID J:93886)
    • some responses are partially corrected by addition of exogenous IL-2, but IL-4 production block is not relieved   (MGI Ref ID J:93886)
    • cells exhibit impaired IL-4 and IL-13 production upon stimulation with anti-CD3, anti-CD3 and anti-CD28 or PMA plus ionomycin   (MGI Ref ID J:93886)
  • abnormal NK cell physiology
    • decreased killing of RMA-S, B16 and, to a lesser extent, YAC-1 cells   (MGI Ref ID J:187430)
    • reduced activating effect of 2B4 towards cytotoxicity   (MGI Ref ID J:187430)
    • reduced conjugation with RMA-S cells, less pronounced than in Sh2d1atm1Pls homozygotes   (MGI Ref ID J:187430)
  • abnormal T cell proliferation   (MGI Ref ID J:93886)
  • decreased IgE level
    • levels are dramatically reduced   (MGI Ref ID J:93886)

Fyntm1Sor/Fyntm1Sor

        involves: 129S7/SvEvBrd
  • immune system phenotype
  • abnormal chemokine level
    • fibrillar beta-amyloid stimulated MCP-1 production in macrophages is reduced to 75% of wild-type   (MGI Ref ID J:80658)
  • abnormal macrophage physiology
    • fibrillar beta-amyloid stimulated reactive oxygen species production is reduced 90% compared to in wild-type cells   (MGI Ref ID J:80658)
    • however, response to zymosan is normal   (MGI Ref ID J:80658)
  • homeostasis/metabolism phenotype
  • abnormal chemokine level
    • fibrillar beta-amyloid stimulated MCP-1 production in macrophages is reduced to 75% of wild-type   (MGI Ref ID J:80658)
  • hematopoietic system phenotype
  • abnormal macrophage physiology
    • fibrillar beta-amyloid stimulated reactive oxygen species production is reduced 90% compared to in wild-type cells   (MGI Ref ID J:80658)
    • however, response to zymosan is normal   (MGI Ref ID J:80658)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Fyntm1Sor related

Cancer Research
Oncogenes

Immunology, Inflammation and Autoimmunity Research
T Cell Receptor Signaling Defects

Neurobiology Research
Behavioral and Learning Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Fyntm1Sor
Allele Name targeted mutation 1, Philippe Soriano
Allele Type Targeted (Null/Knockout)
Common Name(s) fyn-;
Mutation Made ByDr. Philippe Soriano,   Mount Sinai School of Medicine
Strain of Origin129S7/SvEvBrd-Hprt<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt<+>
Gene Symbol and Name Fyn, Fyn proto-oncogene
Chromosome 10
Gene Common Name(s) AI448320; AW552119; SLK; SYN; Src Kinase p59; expressed sequence AI448320; expressed sequence AW552119; p59-FYN;
Molecular Note Replacement of a 3kb fragment containing the first coding exon of the gene with a neomycin cassette. [MGI Ref ID J:2242] [MGI Ref ID J:97095]

Genotyping

Genotyping Information

Genotyping Protocols

Fyntm1Sor, Melt Curve Analysis
Fyntm1Sor, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Stein PL; Lee HM; Rich S; Soriano P. 1992. pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell 70(5):741-50. [PubMed: 1387588]  [MGI Ref ID J:2242]

Additional References

Grant SG; O'Dell TJ; Karl KA; Stein PL; Soriano P; Kandel ER. 1992. Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice [see comments] Science 258(5090):1903-10. [PubMed: 1361685]  [MGI Ref ID J:3417]

Smith CL; Mittaud P; Prescott ED; Fuhrer C; Burden SJ. 2001. Src, Fyn, and Yes are not required for neuromuscular synapse formation but are necessary for stabilization of agrin-induced clusters of acetylcholine receptors. J Neurosci 21(9):3151-60. [PubMed: 11312300]  [MGI Ref ID J:70507]

Fyntm1Sor related

Anidi IU; Servinsky LE; Rentsendorj O; Stephens RS; Scott AL; Pearse DB. 2013. CD36 and Fyn kinase mediate malaria-induced lung endothelial barrier dysfunction in mice infected with Plasmodium berghei. PLoS One 8(8):e71010. [PubMed: 23967147]  [MGI Ref ID J:206356]

Arnaud L; Ballif BA; Forster E; Cooper JA. 2003. Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development. Curr Biol 13(1):9-17. [PubMed: 12526739]  [MGI Ref ID J:109820]

Assarsson E; Kambayashi T; Sandberg JK; Hong S; Taniguchi M; Van Kaer L; Ljunggren HG; Chambers BJ. 2000. CD8+ T cells rapidly acquire NK1.1 and NK cell-associated molecules upon stimulation in vitro and in vivo. J Immunol 165(7):3673-9. [PubMed: 11034371]  [MGI Ref ID J:118029]

Audard V; Zhang SY; Copie-Bergman C; Rucker-Martin C; Ory V; Candelier M; Baia M; Lang P; Pawlak A; Sahali D. 2010. Occurrence of minimal change nephrotic syndrome in classical Hodgkin lymphoma is closely related to the induction of c-mip in Hodgkin-Reed Sternberg cells and podocytes. Blood 115(18):3756-62. [PubMed: 20200355]  [MGI Ref ID J:160246]

Babus LW; Little EM; Keenoy KE; Minami SS; Chen E; Song JM; Caviness J; Koo SY; Pak DT; Rebeck GW; Turner RS; Hoe HS. 2011. Decreased dendritic spine density and abnormal spine morphology in Fyn knockout mice. Brain Res 1415:96-102. [PubMed: 21872217]  [MGI Ref ID J:176593]

Ballif BA; Arnaud L; Cooper JA. 2003. Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases. Brain Res Mol Brain Res 117(2):152-9. [PubMed: 14559149]  [MGI Ref ID J:115650]

Bastie CC; Zong H; Xu J; Busa B; Judex S; Kurland IJ; Pessin JE. 2007. Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the SRC kinase family member Fyn. Cell Metab 5(5):371-81. [PubMed: 17488639]  [MGI Ref ID J:129861]

Beggs HE; Soriano P; Maness PF. 1994. NCAM-dependent neurite outgrowth is inhibited in neurons from Fyn-minus mice. J Cell Biol 127(3):825-33. [PubMed: 7962063]  [MGI Ref ID J:21120]

Biffiger K; Bartsch S; Montag D; Aguzzi A; Schachner M; Bartsch U. 2000. Severe hypomyelination of the murine CNS in the absence of myelin-associated glycoprotein and fyn tyrosine kinase. J Neurosci 20(19):7430-7. [PubMed: 11007902]  [MGI Ref ID J:77301]

Bloch-Queyrat C; Fondaneche MC; Chen R; Yin L; Relouzat F; Veillette A; Fischer A; Latour S. 2005. Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn. J Exp Med 202(1):181-92. [PubMed: 15998796]  [MGI Ref ID J:100630]

Bock HH; Herz J. 2003. Reelin activates SRC family tyrosine kinases in neurons. Curr Biol 13(1):18-26. [PubMed: 12526740]  [MGI Ref ID J:109819]

Brackenbury WJ; Davis TH; Chen C; Slat EA; Detrow MJ; Dickendesher TL; Ranscht B; Isom LL. 2008. Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo. J Neurosci 28(12):3246-56. [PubMed: 18354028]  [MGI Ref ID J:133207]

Cai H; Smith DA; Memarzadeh S; Lowell CA; Cooper JA; Witte ON. 2011. Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Proc Natl Acad Sci U S A 108(16):6579-84. [PubMed: 21464326]  [MGI Ref ID J:171364]

Cannons JL; Wu JZ; Gomez-Rodriguez J; Zhang J; Dong B; Liu Y; Shaw S; Siminovitch KA; Schwartzberg PL. 2010. Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation. J Immunol 185(5):2819-27. [PubMed: 20668219]  [MGI Ref ID J:163263]

Cannons JL; Yu LJ; Hill B; Mijares LA; Dombroski D; Nichols KE; Antonellis A; Koretzky GA; Gardner K; Schwartzberg PL. 2004. SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1. Immunity 21(5):693-706. [PubMed: 15539155]  [MGI Ref ID J:93887]

Cannons JL; Yu LJ; Jankovic D; Crotty S; Horai R; Kirby M; Anderson S; Cheever AW; Sher A; Schwartzberg PL. 2006. SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation. J Exp Med 203(6):1551-65. [PubMed: 16754717]  [MGI Ref ID J:124375]

Chaimowitz NS; Falanga YT; Ryan JJ; Conrad DH. 2013. Fyn kinase is required for optimal humoral responses. PLoS One 8(4):e60640. [PubMed: 23593269]  [MGI Ref ID J:200582]

Chan B; Lanyi A; Song HK; Griesbach J; Simarro-Grande M; Poy F; Howie D; Sumegi J; Terhorst C; Eck MJ. 2003. SAP couples Fyn to SLAM immune receptors. Nat Cell Biol 5(2):155-60. [PubMed: 12545174]  [MGI Ref ID J:109312]

Chari R; Kim S; Murugappan S; Sanjay A; Daniel JL; Kunapuli SP. 2009. Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion. Blood 114(14):3056-63. [PubMed: 19587372]  [MGI Ref ID J:153266]

Charles N; Watford WT; Ramos HL; Hellman L; Oettgen HC; Gomez G; Ryan JJ; O'Shea JJ; Rivera J. 2009. Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation. Immunity 30(4):533-43. [PubMed: 19362019]  [MGI Ref ID J:147963]

Chen K; Li W; Major J; Rahaman SO; Febbraio M; Silverstein RL. 2011. Vav guanine nucleotide exchange factors link hyperlipidemia and a prothrombotic state. Blood 117(21):5744-50. [PubMed: 21427288]  [MGI Ref ID J:173265]

Chen YT; Kung JT. 2005. CD1d-independent developmental acquisition of prompt IL-4 gene inducibility in thymus CD161(NK1)-CD44lowCD4+CD8- T cells is associated with complementarity determining region 3-diverse and biased Vbeta2/Vbeta7/Vbeta8/Valpha3.2 T cell receptor usage. J Immunol 175(10):6537-50. [PubMed: 16272308]  [MGI Ref ID J:119395]

Chin J; Palop JJ; Yu GQ; Kojima N; Masliah E; Mucke L. 2004. Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice. J Neurosci 24(19):4692-7. [PubMed: 15140940]  [MGI Ref ID J:96892]

Chu DH; van Oers NS; Malissen M; Harris J; Elder M; Weiss A. 1999. Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression. J Immunol 163(5):2610-20. [PubMed: 10453000]  [MGI Ref ID J:57092]

Cioni JM; Telley L; Saywell V; Cadilhac C; Jourdan C; Huber AB; Huang JZ; Jahannault-Talignani C; Ango F. 2013. SEMA3A signaling controls layer-specific interneuron branching in the cerebellum. Curr Biol 23(10):850-61. [PubMed: 23602477]  [MGI Ref ID J:199730]

Cordero JB; Ridgway RA; Valeri N; Nixon C; Frame MC; Muller WJ; Vidal M; Sansom OJ. 2014. c-Src drives intestinal regeneration and transformation. EMBO J 33(13):1474-91. [PubMed: 24788409]  [MGI Ref ID J:211668]

Criscuoli ML; Nguyen M; Eliceiri BP. 2005. Tumor metastasis but not tumor growth is dependent on Src-mediated vascular permeability. Blood 105(4):1508-14. [PubMed: 15486073]  [MGI Ref ID J:95907]

Dao T; Guo D; Ploss A; Stolzer A; Saylor C; Boursalian TE; Im JS; Sant'Angelo DB. 2004. Development of CD1d-restricted NKT cells in the mouse thymus. Eur J Immunol 34(12):3542-52. [PubMed: 15549774]  [MGI Ref ID J:94598]

Das R; Bassiri H; Guan P; Wiener S; Banerjee PP; Zhong MC; Veillette A; Orange JS; Nichols KE. 2013. The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood 121(17):3386-95. [PubMed: 23430111]  [MGI Ref ID J:196692]

Dautigny N; Le Campion A; Lucas B. 1999. Timing and casting for actors of thymic negative selection. J Immunol 162(3):1294-302. [PubMed: 9973382]  [MGI Ref ID J:124433]

Davidson D; Schraven B; Veillette A. 2007. PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes. Mol Cell Biol 27(5):1960-73. [PubMed: 17210649]  [MGI Ref ID J:118860]

Davidson D; Shi X; Zhang S; Wang H; Nemer M; Ono N; Ohno S; Yanagi Y; Veillette A. 2004. Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation. Immunity 21(5):707-17. [PubMed: 15539156]  [MGI Ref ID J:93886]

De Fazio SR; Warner CM. 2007. Activation of T cells by cross-linking Qa-2, the ped gene product, requires Fyn. Am J Reprod Immunol 58(4):315-24. [PubMed: 17845201]  [MGI Ref ID J:149050]

Derkinderen P; Toutant M; Kadare G; Ledent C; Parmentier M; Girault JA. 2001. Dual role of Fyn in the regulation of FAK+6,7 by cannabinoids in hippocampus. J Biol Chem 276(41):38289-96. [PubMed: 11468287]  [MGI Ref ID J:120418]

Dey N; Crosswell HE; De P; Parsons R; Peng Q; Su JD; Durden DL. 2008. The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration. Cancer Res 68(6):1862-71. [PubMed: 18339867]  [MGI Ref ID J:133323]

Dong Z; Davidson D; Perez-Quintero LA; Kurosaki T; Swat W; Veillette A. 2012. The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells. Immunity 36(6):974-85. [PubMed: 22683124]  [MGI Ref ID J:187430]

Donlin LT; Roman CA; Adlam M; Regelmann AG; Alexandropoulos K. 2002. Defective thymocyte maturation by transgenic expression of a truncated form of the T lymphocyte adapter molecule and Fyn substrate, Sin. J Immunol 169(12):6900-9. [PubMed: 12471123]  [MGI Ref ID J:118421]

Dutta M; Schwartzberg PL. 2012. Characterization of Ly108 in the thymus: evidence for distinct properties of a novel form of Ly108. J Immunol 188(7):3031-41. [PubMed: 22393150]  [MGI Ref ID J:183088]

Eberl G; Lowin-Kropf B; MacDonald HR. 1999. Cutting edge: NKT cell development is selectively impaired in Fyn-deficient mice. J Immunol 163(8):4091-4. [PubMed: 10510341]  [MGI Ref ID J:57985]

Eliceiri BP; Paul R; Schwartzberg PL; Hood JD; Leng J; Cheresh DA. 1999. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol Cell 4(6):915-24. [PubMed: 10635317]  [MGI Ref ID J:59158]

Engel I; Murre C. 2004. E2A proteins enforce a proliferation checkpoint in developing thymocytes. EMBO J 23(1):202-11. [PubMed: 14685278]  [MGI Ref ID J:115665]

Falanga YT; Chaimowitz NS; Charles N; Finkelman FD; Pullen NA; Barbour S; Dholaria K; Faber T; Kolawole M; Huang B; Odom S; Rivera J; Carlyon J; Conrad DH; Spiegel S; Oskeritzian CA; Ryan JJ. 2012. Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis. J Immunol 188(9):4360-8. [PubMed: 22450804]  [MGI Ref ID J:188465]

Farris SP; Miles MF. 2013. Fyn-dependent gene networks in acute ethanol sensitivity. PLoS One 8(11):e82435. [PubMed: 24312422]  [MGI Ref ID J:209750]

Filby A; Seddon B; Kleczkowska J; Salmond R; Tomlinson P; Smida M; Lindquist JA; Schraven B; Zamoyska R. 2007. Fyn regulates the duration of TCR engagement needed for commitment to effector function. J Immunol 179(7):4635-44. [PubMed: 17878361]  [MGI Ref ID J:152346]

Frossi B; Rivera J; Hirsch E; Pucillo C. 2007. Selective activation of Fyn/PI3K and p38 MAPK regulates IL-4 production in BMMC under nontoxic stress condition. J Immunol 178(4):2549-55. [PubMed: 17277164]  [MGI Ref ID J:143971]

Gadue P; Morton N; Stein PL. 1999. The Src family tyrosine kinase Fyn regulates natural killer T cell development. J Exp Med 190(8):1189-96. [PubMed: 10523617]  [MGI Ref ID J:110943]

Gadue P; Yin L; Jain S; Stein PL. 2004. Restoration of NK T cell development in fyn-mutant mice by a TCR reveals a requirement for Fyn during early NK T cell ontogeny. J Immunol 172(10):6093-100. [PubMed: 15128794]  [MGI Ref ID J:89871]

Garcia-Roman J; Ibarra-Sanchez A; Lamas M; Gonzalez Espinosa C. 2010. VEGF secretion during hypoxia depends on free radicals-induced Fyn kinase activity in mast cells. Biochem Biophys Res Commun 401(2):262-7. [PubMed: 20850416]  [MGI Ref ID J:165846]

Gomez G; Gonzalez-Espinosa C; Odom S; Baez G; Cid ME; Ryan JJ; Rivera J. 2005. Impaired FcepsilonRI-dependent gene expression and defective eicosanoid and cytokine production as a consequence of Fyn deficiency in mast cells. J Immunol 175(11):7602-10. [PubMed: 16301670]  [MGI Ref ID J:122154]

Grant SG; Karl KA; Kiebler MA; Kandel ER. 1995. Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice. Genes Dev 9(15):1909-21. [PubMed: 7544314]  [MGI Ref ID J:28276]

Grant SG; O'Dell TJ; Karl KA; Stein PL; Soriano P; Kandel ER. 1992. Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice [see comments] Science 258(5090):1903-10. [PubMed: 1361685]  [MGI Ref ID J:3417]

Greenberg RS; Bernstein AM; Benezra M; Gelman IH; Taliana L; Masur SK. 2006. FAK-dependent regulation of myofibroblast differentiation. FASEB J 20(7):1006-8. [PubMed: 16585062]  [MGI Ref ID J:111499]

Hager E; Hawwari A; Matsuda JL; Krangel MS; Gapin L. 2007. Multiple constraints at the level of TCRalpha rearrangement impact Valpha14i NKT cell development. J Immunol 179(4):2228-34. [PubMed: 17675483]  [MGI Ref ID J:151224]

Hoe HS; Minami SS; Makarova A; Lee J; Hyman BT; Matsuoka Y; Rebeck GW. 2008. Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing. J Biol Chem 283(10):6288-99. [PubMed: 18089558]  [MGI Ref ID J:134018]

Huang J; Lo PF; Zal T; Gascoigne NR; Smith BA; Levin SD; Grey HM. 2002. CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse. Proc Natl Acad Sci U S A 99(14):9369-73. [PubMed: 12077322]  [MGI Ref ID J:126523]

Huerta PT; Scearce KA; Farris SM; Empson RM; Prusky GT. 1996. Preservation of spatial learning in fyn tyrosine kinase knockout mice. Neuroreport 7(10):1685-9. [PubMed: 8904782]  [MGI Ref ID J:36651]

Jurd R; Tretter V; Walker J; Brandon NJ; Moss SJ. 2010. Fyn kinase contributes to tyrosine phosphorylation of the GABA(A) receptor gamma2 subunit. Mol Cell Neurosci 44(2):129-34. [PubMed: 20233604]  [MGI Ref ID J:164138]

Kennedy DJ; Kuchibhotla S; Westfall KM; Silverstein RL; Morton RE; Febbraio M. 2011. A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling. Cardiovasc Res 89(3):604-13. [PubMed: 21088116]  [MGI Ref ID J:186882]

Kim JK; Klinger M; Benjamin J; Xiao Y; Erle DJ; Littman DR; Killeen N. 2009. Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking. PLoS One 4(8):e6580. [PubMed: 19668367]  [MGI Ref ID J:152472]

Kim S; Kunapuli SP. 2011. Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase. J Biol Chem 286(27):24170-9. [PubMed: 21592972]  [MGI Ref ID J:174988]

Kitaura J; Eto K; Kinoshita T; Kawakami Y; Leitges M; Lowell CA; Kawakami T. 2005. Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases. J Immunol 174(8):4495-504. [PubMed: 15814670]  [MGI Ref ID J:98164]

Klinghoffer RA; Sachsenmaier C; Cooper JA; Soriano P. 1999. Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J 18(9):2459-71. [PubMed: 10228160]  [MGI Ref ID J:54973]

Knezevic N; Tauseef M; Thennes T; Mehta D. 2009. The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin. J Exp Med 206(12):2761-77. [PubMed: 19917775]  [MGI Ref ID J:154974]

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Kojima N; Wang J; Mansuy IM; Grant SG; Mayford M; Kandel ER. 1997. Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene. Proc Natl Acad Sci U S A 94(9):4761-5. [PubMed: 9114065]  [MGI Ref ID J:80637]

Kovalovsky D; Alonzo ES; Uche OU; Eidson M; Nichols KE; Sant'Angelo DB. 2010. PLZF induces the spontaneous acquisition of memory/effector functions in T cells independently of NKT cell-related signals. J Immunol 184(12):6746-55. [PubMed: 20495068]  [MGI Ref ID J:161305]

Krebs B; Wiebelitz A; Balitzki-Korte B; Vassallo N; Paluch S; Mitteregger G; Onodera T; Kretzschmar HA; Herms J. 2007. Cellular prion protein modulates the intracellular calcium response to hydrogen peroxide. J Neurochem 100(2):358-67. [PubMed: 17241158]  [MGI Ref ID J:121101]

Kuo G; Arnaud L; Kronstad-O'Brien P; Cooper JA. 2005. Absence of Fyn and Src causes a reeler-like phenotype. J Neurosci 25(37):8578-86. [PubMed: 16162939]  [MGI Ref ID J:101055]

Laird RM; Hayes SM. 2009. Profiling of the early transcriptional response of murine gammadelta T cells following TCR stimulation. Mol Immunol 46(11-12):2429-38. [PubMed: 19439358]  [MGI Ref ID J:149535]

Laird RM; Hayes SM. 2010. Roles of the Src tyrosine kinases Lck and Fyn in regulating gammadeltaTCR signal strength. PLoS One 5(1):e8899. [PubMed: 20126650]  [MGI Ref ID J:157616]

Lee WT; Prasad A; Watson AR. 2012. Anergy in CD4 memory T lymphocytes. II. Abrogation of TCR-induced formation of membrane signaling complexes. Cell Immunol 276(1-2):26-34. [PubMed: 22663768]  [MGI Ref ID J:188360]

Liao XC; Littman DR; Weiss A. 1997. Itk and Fyn make independent contributions to T cell activation. J Exp Med 186(12):2069-73. [PubMed: 9396778]  [MGI Ref ID J:44879]

Loers G; Aboul-Enein F; Bartsch U; Lassmann H; Schachner M. 2004. Comparison of myelin, axon, lipid, and immunopathology in the central nervous system of differentially myelin-compromised mutant mice: a morphological and biochemical study. Mol Cell Neurosci 27(2):175-89. [PubMed: 15485773]  [MGI Ref ID J:93204]

Lovatt M; Filby A; Parravicini V; Werlen G; Palmer E; Zamoyska R. 2006. Lck Regulates the Threshold of Activation in Primary T Cells, While both Lck and Fyn Contribute to the Magnitude of the Extracellular Signal-Related Kinase Response. Mol Cell Biol 26(22):8655-65. [PubMed: 16966372]  [MGI Ref ID J:114668]

Lu Z; Ku L; Chen Y; Feng Y. 2005. Developmental abnormalities of myelin basic protein expression in fyn knock-out brain reveal a role of Fyn in posttranscriptional regulation. J Biol Chem 280(1):389-95. [PubMed: 15528192]  [MGI Ref ID J:104981]

Luo J; Gupta V; Kern B; Tash JS; Sanchez G; Blanco G; Kinsey WH. 2012. Role of FYN kinase in spermatogenesis: defects characteristic of Fyn-null sperm in mice. Biol Reprod 86(1):1-8. [PubMed: 21918125]  [MGI Ref ID J:185783]

Mamchak AA; Sullivan BM; Hou B; Lee LM; Gilden JK; Krummel MF; Locksley RM; DeFranco AL. 2008. Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J Immunol 181(8):5374-85. [PubMed: 18832694]  [MGI Ref ID J:140767]

Mamchak AA; Thien CB; Dagger SA; Lyandres J; Jiang S; Langdon WY; DeFranco AL. 2010. Unaltered negative selection and Treg development of self-reactive thymocytes in TCR transgenic Fyn-deficient mice. Eur J Immunol 40(2):539-47. [PubMed: 19904769]  [MGI Ref ID J:157790]

Martin-Cofreces NB; Sancho D; Fernandez E; Vicente-Manzanares M; Gordon-Alonso M; Montoya MC; Michel F; Acuto O; Alarcon B; Sanchez-Madrid F. 2006. Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR. J Immunol 176(7):4201-7. [PubMed: 16547257]  [MGI Ref ID J:129875]

Mason LH; Willette-Brown J; Taylor LS; McVicar DW. 2006. Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45. J Immunol 176(11):6615-23. [PubMed: 16709819]  [MGI Ref ID J:131771]

McGinnis LK; Kinsey WH; Albertini DF. 2009. Functions of Fyn kinase in the completion of meiosis in mouse oocytes. Dev Biol 327(2):280-7. [PubMed: 19118543]  [MGI Ref ID J:145987]

McGough NN; He DY; Logrip ML; Jeanblanc J; Phamluong K; Luong K; Kharazia V; Janak PH; Ron D. 2004. RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addiction. J Neurosci 24(46):10542-52. [PubMed: 15548669]  [MGI Ref ID J:96588]

Minami SS; Clifford TG; Hoe HS; Matsuoka Y; Rebeck GW. 2012. Fyn knock-down increases Abeta, decreases phospho-tau, and worsens spatial learning in 3xTg-AD mice. Neurobiol Aging 33(4):825.e15-24. [PubMed: 21741124]  [MGI Ref ID J:188201]

Moore KJ; El Khoury J; Medeiros LA; Terada K; Geula C; Luster AD; Freeman MW. 2002. A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid. J Biol Chem 277(49):47373-9. [PubMed: 12239221]  [MGI Ref ID J:80658]

Morse WR; Whitesides JG 3rd; LaMantia AS; Maness PF. 1998. p59fyn and pp60c-src modulate axonal guidance in the developing mouse olfactory pathway. J Neurobiol 36(1):53-63. [PubMed: 9658338]  [MGI Ref ID J:50997]

Nabekura T; Kanaya M; Shibuya A; Fu G; Gascoigne NR; Lanier LL. 2014. Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection. Immunity 40(2):225-34. [PubMed: 24440149]  [MGI Ref ID J:209371]

Nichols KE; Hom J; Gong SY; Ganguly A; Ma CS; Cannons JL; Tangye SG; Schwartzberg PL; Koretzky GA; Stein PL. 2005. Regulation of NKT cell development by SAP, the protein defective in XLP. Nat Med 11(3):340-345. [PubMed: 15711562]  [MGI Ref ID J:97095]

Nishio H; Takase I; Fukunishi S; Takagi T; Tamura A; Miyazaki T; Suzuki K. 2005. Evidence for involvement of p59fyn in fasting-induced thymic involution. Scand J Immunol 62(2):103-7. [PubMed: 16101815]  [MGI Ref ID J:114307]

Parravicini V; Gadina M; Kovarova M; Odom S; Gonzalez-Espinosa C; Furumoto Y; Saitoh S; Samelson LE; O'Shea JJ; Rivera J. 2002. Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat Immunol 3(8):741-8. [PubMed: 12089510]  [MGI Ref ID J:109153]

Pasquier B; Yin L; Fondaneche MC; Relouzat F; Bloch-Queyrat C; Lambert N; Fischer A; de Saint-Basile G; Latour S. 2005. Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product. J Exp Med 201(5):695-701. [PubMed: 15738056]  [MGI Ref ID J:96625]

Paul R; Zhang ZG; Eliceiri BP; Jiang Q; Boccia AD; Zhang RL; Chopp M; Cheresh DA. 2001. Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke. Nat Med 7(2):222-7. [PubMed: 11175854]  [MGI Ref ID J:126862]

Porro F; Rosato-Siri M; Leone E; Costessi L; Iaconcig A; Tongiorgi E; Muro AF. 2010. beta-adducin (Add2) KO mice show synaptic plasticity, motor coordination and behavioral deficits accompanied by changes in the expression and phosphorylation levels of the alpha- and gamma-adducin subunits. Genes Brain Behav 9(1):84-96. [PubMed: 19900187]  [MGI Ref ID J:169203]

Quek LS; Pasquet JM; Hers I; Cornall R; Knight G; Barnes M; Hibbs ML; Dunn AR; Lowell CA; Watson SP. 2000. Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway. Blood 96(13):4246-53. [PubMed: 11110698]  [MGI Ref ID J:110337]

Rajasekaran K; Kumar P; Schuldt KM; Peterson EJ; Vanhaesebroeck B; Dixit V; Thakar MS; Malarkannan S. 2013. Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells. Nat Immunol 14(11):1127-36. [PubMed: 24036998]  [MGI Ref ID J:208208]

Rajasekharan S; Baker KA; Horn KE; Jarjour AA; Antel JP; Kennedy TE. 2009. Netrin 1 and Dcc regulate oligodendrocyte process branching and membrane extension via Fyn and RhoA. Development 136(3):415-26. [PubMed: 19141671]  [MGI Ref ID J:144192]

Reddy KB; Smith DM; Plow EF. 2008. Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signaling. J Cell Sci 121(Pt 10):1641-8. [PubMed: 18430780]  [MGI Ref ID J:139813]

Ridgway RA; Serrels B; Mason S; Kinnaird A; Muir M; Patel H; Muller WJ; Sansom OJ; Brunton VG. 2012. Focal adhesion kinase is required for beta-catenin-induced mobilization of epidermal stem cells. Carcinogenesis 33(12):2369-76. [PubMed: 22971575]  [MGI Ref ID J:193298]

Ruschmann J; Ho V; Antignano F; Kuroda E; Lam V; Ibaraki M; Snyder K; Kim C; Flavell RA; Kawakami T; Sly L; Turhan AG; Krystal G. 2010. Tyrosine phosphorylation of SHIP promotes its proteasomal degradation. Exp Hematol 38(5):392-402, 402.e1. [PubMed: 20304029]  [MGI Ref ID J:164034]

Saijo K; Schmedt C; Su IH; Karasuyama H; Lowell CA; Reth M; Adachi T; Patke A; Santana A; Tarakhovsky A. 2003. Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol 4(3):274-9. [PubMed: 12563261]  [MGI Ref ID J:115080]

Samayawardhena LA; Kapur R; Craig AW. 2007. Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells. Blood 109(9):3679-86. [PubMed: 17213284]  [MGI Ref ID J:145328]

Schafe GE; Stein PL; Park CR; Bernstein IL. 1996. Taste aversion learning in fyn mutant mice. Behav Neurosci 110(4):845-8. [PubMed: 8864276]  [MGI Ref ID J:35216]

Seddon B; Tomlinson P; Zamoyska R. 2003. Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat Immunol 4(7):680-6. [PubMed: 12808452]  [MGI Ref ID J:129178]

Seddon B; Zamoyska R. 2002. TCR signals mediated by Src family kinases are essential for the survival of naive T cells. J Immunol 169(6):2997-3005. [PubMed: 12218114]  [MGI Ref ID J:133734]

Severin S; Pollitt AY; Navarro-Nunez L; Nash CA; Mourao-Sa D; Eble JA; Senis YA; Watson SP. 2011. Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling. J Biol Chem 286(6):4107-16. [PubMed: 21098033]  [MGI Ref ID J:169492]

Smith CL; Mittaud P; Prescott ED; Fuhrer C; Burden SJ. 2001. Src, Fyn, and Yes are not required for neuromuscular synapse formation but are necessary for stabilization of agrin-induced clusters of acetylcholine receptors. J Neurosci 21(9):3151-60. [PubMed: 11312300]  [MGI Ref ID J:70507]

Sperber BR; Boyle-Walsh EA; Engleka MJ; Gadue P; Peterson AC; Stein PL; Scherer SS; McMorris FA. 2001. A unique role for Fyn in CNS myelination. J Neurosci 21(6):2039-47. [PubMed: 11245687]  [MGI Ref ID J:109485]

Stein PL; Vogel H; Soriano P. 1994. Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice. Genes Dev 8(17):1999-2007. [PubMed: 7958873]  [MGI Ref ID J:20346]

Stuart LM; Bell SA; Stewart CR; Silver JM; Richard J; Goss JL; Tseng AA; Zhang A; Khoury JB; Moore KJ. 2007. CD36 Signals to the Actin Cytoskeleton and Regulates Microglial Migration via a p130Cas Complex. J Biol Chem 282(37):27392-401. [PubMed: 17623670]  [MGI Ref ID J:124948]

Sugie K; Jeon MS; Grey HM. 2004. Activation of naive CD4 T cells by anti-CD3 reveals an important role for Fyn in Lck-mediated signaling. Proc Natl Acad Sci U S A 101(41):14859-64. [PubMed: 15465914]  [MGI Ref ID J:93480]

Tamura T; Igarashi O; Hino A; Yamane H; Aizawa S; Kato T; Nariuchi H. 2001. Impairment in the expression and activity of Fyn during differentiation of naive CD4+ T cells into the Th2 subset. J Immunol 167(4):1962-9. [PubMed: 11489976]  [MGI Ref ID J:110880]

Thomas SM; Soriano P; Imamoto A. 1995. Specific and redundant roles of Src and Fyn in organizing the cytoskeleton. Nature 376(6537):267-71. [PubMed: 7617039]  [MGI Ref ID J:113005]

Tse MC; Liu X; Yang S; Ye K; Chan CB. 2013. Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction. Mol Cell Biol 33(9):1797-808. [PubMed: 23438599]  [MGI Ref ID J:203754]

Um JW; Nygaard HB; Heiss JK; Kostylev MA; Stagi M; Vortmeyer A; Wisniewski T; Gunther EC; Strittmatter SM. 2012. Alzheimer amyloid-beta oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Nat Neurosci 15(9):1227-35. [PubMed: 22820466]  [MGI Ref ID J:190064]

Usardi A; Pooler AM; Seereeram A; Reynolds CH; Derkinderen P; Anderton B; Hanger DP; Noble W; Williamson R. 2011. Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau. FEBS J 278(16):2927-37. [PubMed: 21692989]  [MGI Ref ID J:190792]

Verma R; Wharram B; Kovari I; Kunkel R; Nihalani D; Wary KK; Wiggins RC; Killen P; Holzman LB. 2003. Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin. J Biol Chem 278(23):20716-23. [PubMed: 12668668]  [MGI Ref ID J:124526]

Wagner MC; Rhodes G; Wang E; Pruthi V; Arif E; Saleem MA; Wean SE; Garg P; Verma R; Holzman LB; Gattone V; Molitoris BA; Nihalani D. 2008. Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1. J Biol Chem 283(51):35579-89. [PubMed: 18922801]  [MGI Ref ID J:144583]

Wang J; Carnicella S; Phamluong K; Jeanblanc J; Ronesi JA; Chaudhri N; Janak PH; Lovinger DM; Ron D. 2007. Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior. J Neurosci 27(13):3593-602. [PubMed: 17392475]  [MGI Ref ID J:120370]

Watson AR; Janik DK; Lee WT. 2012. Superantigen-induced CD4 memory T cell anergy. I. Staphylococcal enterotoxin B induces Fyn-mediated negative signaling. Cell Immunol 276(1-2):16-25. [PubMed: 22386537]  [MGI Ref ID J:188306]

Yang Y; Tarabra E; Yang GS; Vaitheesvaran B; Palacios G; Kurland IJ; Pessin JE; Bastie CC. 2013. Alteration of de novo glucose production contributes to fasting hypoglycaemia in Fyn deficient mice. PLoS One 8(11):e81866. [PubMed: 24312371]  [MGI Ref ID J:209754]

Yin H; Liu J; Li Z; Berndt MC; Lowell CA; Du X. 2008. Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway. Blood 112(4):1139-46. [PubMed: 18550847]  [MGI Ref ID J:139181]

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Zikherman J; Jenne C; Watson S; Doan K; Raschke W; Goodnow CC; Weiss A. 2010. CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Immunity 32(3):342-54. [PubMed: 20346773]  [MGI Ref ID J:158876]

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    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

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At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

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    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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