Strain Name:

B6;129S4-Insrtm1Dac/J

Stock Number:

002426

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
 
Donating InvestigatorDr. Domenico Accili,   Columbia University

Appearance
black
Related Genotype: a/a

Description
Mice homozygous for the Insrtm1Dac targeted mutation die 48-72 hours after birth due to diabetic keto-acidosis which causes weight loss by dehydration and protein wasting. There are no apparent gross anatomical or morphological changes. Embryonic growth is unaffected. Heterozygotes exhibit a form of mild insulin resistance.

Control Information

  Control
   Wild-type from the colony
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Insrtm1Dac allele
002939   B6.129S4-Insrtm1Dac/J
View Strains carrying   Insrtm1Dac     (1 strain)

Strains carrying other alleles of Insr
006955   B6.129S4(FVB)-Insrtm1Khn/J
View Strains carrying other alleles of Insr     (1 strain)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- No similarity to the expected human disease phenotype was found. One or more human genes are associated with this human disease. The mouse genotype may involve mutations to orthologs of one or more of these genes, but the phenotype did not resemble the disease.
Donohue Syndrome
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Diabetes Mellitus, Insulin-Resistant, with Acanthosis Nigricans   (INSR)
Hyperinsulinemic Hypoglycemia, Familial, 5; HHF5   (INSR)
Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, and Somatic Abnormalities   (INSR)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Insrtm1Dac/Insr+

        involves: 129 * C57BL/6J
  • homeostasis/metabolism phenotype
  • increased circulating insulin level
    • both fasting and fed insulin levels were higher than in wild-type mice   (MGI Ref ID J:135659)
  • insulin resistance   (MGI Ref ID J:135659)
  • endocrine/exocrine gland phenotype
  • increased pancreatic beta cell mass
    • increased beta cell mass   (MGI Ref ID J:135659)

Insrtm1Dac/Insrtm1Dac

        involves: 129S4/SvJae * C57BL/6
  • mortality/aging
  • complete postnatal lethality
    • mice die within 72 hours of birth   (MGI Ref ID J:33408)
  • homeostasis/metabolism phenotype
  • abnormal glucose homeostasis
    • about 10% with diabetes   (MGI Ref ID J:79560)
    • hyperglycemia
      • plasma glucose levels rose sharply after birth; measured between 24-37 mmol/l   (MGI Ref ID J:33408)
    • increased circulating insulin level
      • plasma insulin levels rose sharply after birth to levels approximately 7 times that of controls   (MGI Ref ID J:33408)
  • ketoaciduria
    • homozygous mice developed diabetic ketoacidosis, with ketone bodies in urine; urinary acetoacetate measured between 8-16 mmol/l   (MGI Ref ID J:33408)
  • liver/biliary system phenotype
  • hepatic steatosis
    • steatosis; fatty degeneration of liver   (MGI Ref ID J:33408)
  • renal/urinary system phenotype
  • ketoaciduria
    • homozygous mice developed diabetic ketoacidosis, with ketone bodies in urine; urinary acetoacetate measured between 8-16 mmol/l   (MGI Ref ID J:33408)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Insrtm1Dac/Insr+

        involves: C3H/HeH * C57BL/6
  • endocrine/exocrine gland phenotype
  • increased insulin secretion
    • beta islet cells secrete about twice as much insulin as controls in the absence of extracellular glucose   (MGI Ref ID J:141688)
  • homeostasis/metabolism phenotype
  • increased circulating insulin level
    • circulating insulin levels are almost 3-fold higher and continue to remain higher than controls during a glucose challenge   (MGI Ref ID J:141688)
  • increased insulin secretion
    • beta islet cells secrete about twice as much insulin as controls in the absence of extracellular glucose   (MGI Ref ID J:141688)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Insrtm1Dac related

Diabetes and Obesity Research
Insulin Receptors and Growth Factors
Insulin Resistance
Type 2 Diabetes (NIDDM)

Endocrine Deficiency Research
Adipose Defects

Internal/Organ Research
Adipose Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Insrtm1Dac
Allele Name targeted mutation 1, Domenico Accili
Allele Type Targeted (Null/Knockout)
Common Name(s) IR-; IRKO; Insr-; L1;
Mutation Made ByProf. Sara Fuchs,   National Institutes of Health
Strain of Origin129S4/SvJae
ES Cell Line NameJ1
ES Cell Line Strain129S4/SvJae
Gene Symbol and Name Insr, insulin receptor
Chromosome 8
Gene Common Name(s) 4932439J01Rik; CD220; D630014A15Rik; HHF5; IR; IR-A; IR-B; RIKEN cDNA 4932439J01 gene; RIKEN cDNA D630014A15 gene;
Molecular Note A premature chain termination was introduced downstream from codon 306 of exon 4 of the gene. Western blots of brain extracts from homozygous mutant mice showed no detectable insulin receptor protein. Reverse transcriptase-PCR of RNA isolated from brain, liver and skeletal muscle showed no transcript. [MGI Ref ID J:33408]

Genotyping

Genotyping Information

Genotyping Protocols

Insrtm1Dac, Separated PCR
NEOTD (Generic Neo), Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Accili D; Drago J; Lee EJ; Johnson MD; Cool MH; Salvatore P; Asico LD; Jose PA; Taylor SI; Westphal H. 1996. Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nat Genet 12(1):106-9. [PubMed: 8528241]  [MGI Ref ID J:33408]

Additional References

Insrtm1Dac related

Banks AS; Kim-Muller JY; Mastracci TL; Kofler NM; Qiang L; Haeusler RA; Jurczak MJ; Laznik D; Heinrich G; Samuel VT; Shulman GI; Papaioannou VE; Accili D. 2011. Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice. Cell Metab 14(5):587-97. [PubMed: 22055502]  [MGI Ref ID J:179687]

Bruning JC; Winnay J; Bonner-Weir S; Taylor SI; Accili D; Kahn CR. 1997. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 88(4):561-72. [PubMed: 9038347]  [MGI Ref ID J:38502]

Chang CL; Seo T; Du CB; Accili D; Deckelbaum RJ. 2010. n-3 Fatty acids decrease arterial low-density lipoprotein cholesterol delivery and lipoprotein lipase levels in insulin-resistant mice. Arterioscler Thromb Vasc Biol 30(12):2510-7. [PubMed: 20930167]  [MGI Ref ID J:182093]

Cinti S; Eberbach S; Castellucci M; Accili D. 1998. Lack of insulin receptors affects the formation of white adipose tissue in mice. A morphometric and ultrastructural analysis. Diabetologia 41(2):171-7. [PubMed: 9498650]  [MGI Ref ID J:107160]

Das P; Parsons AD; Scarborough J; Hoffman J; Wilson J; Thompson RN; Overton JM; Fadool DA. 2005. Electrophysiological and behavioral phenotype of insulin receptor defective mice. Physiol Behav 86(3):287-96. [PubMed: 16176826]  [MGI Ref ID J:106630]

Deyev IE; Sohet F; Vassilenko KP; Serova OV; Popova NV; Zozulya SA; Burova EB; Houillier P; Rzhevsky DI; Berchatova AA; Murashev AN; Chugunov AO; Efremov RG; Nikol'sky NN; Bertelli E; Eladari D; Petrenko AG. 2011. Insulin receptor-related receptor as an extracellular alkali sensor. Cell Metab 13(6):679-89. [PubMed: 21641549]  [MGI Ref ID J:176088]

Duncan ER; Walker SJ; Ezzat VA; Wheatcroft SB; Li JM; Shah AM; Kearney MT. 2007. Accelerated endothelial dysfunction in mild prediabetic insulin resistance: the early role of reactive oxygen species. Am J Physiol Endocrinol Metab 293(5):E1311-9. [PubMed: 17711985]  [MGI Ref ID J:126762]

Esquiliano DR; Guo W; Liang L; Dikkes P; Lopez MF. 2009. Placental glycogen stores are increased in mice with H19 null mutations but not in those with insulin or IGF type 1 receptor mutations. Placenta 30(8):693-9. [PubMed: 19524295]  [MGI Ref ID J:155641]

Federici M; Hribal ML; Menghini R; Kanno H; Marchetti V; Porzio O; Sunnarborg SW; Rizza S; Serino M; Cunsolo V; Lauro D; Mauriello A; Smookler DS; Sbraccia P; Sesti G; Lee DC; Khokha R; Accili D; Lauro R. 2005. Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha. J Clin Invest 115(12):3494-505. [PubMed: 16294222]  [MGI Ref ID J:104707]

Goldsworthy M; Hugill A; Freeman H; Horner E; Shimomura K; Bogani D; Pieles G; Mijat V; Arkell R; Bhattacharya S; Ashcroft FM; Cox RD. 2008. Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. Diabetes 57(8):2234-44. [PubMed: 18477811]  [MGI Ref ID J:141688]

Han S; Liang CP; DeVries-Seimon T; Ranalletta M; Welch CL; Collins-Fletcher K; Accili D; Tabas I; Tall AR. 2006. Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. Cell Metab 3(4):257-66. [PubMed: 16581003]  [MGI Ref ID J:129653]

Han S; Liang CP; Westerterp M; Senokuchi T; Welch CL; Wang Q; Matsumoto M; Accili D; Tall AR. 2009. Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice. J Clin Invest 119(4):1029-41. [PubMed: 19273907]  [MGI Ref ID J:149755]

Irwin R; Lin HV; Motyl KJ; McCabe LR. 2006. Normal bone density obtained in the absence of insulin receptor expression in bone. Endocrinology 147(12):5760-7. [PubMed: 16973725]  [MGI Ref ID J:117250]

Kahn MB; Yuldasheva NY; Cubbon RM; Smith J; Rashid ST; Viswambharan H; Imrie H; Abbas A; Rajwani A; Aziz A; Baliga V; Sukumar P; Gage M; Kearney MT; Wheatcroft SB. 2011. Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration. Diabetes 60(4):1295-303. [PubMed: 21317296]  [MGI Ref ID J:171762]

Kido Y; Burks DJ; Withers D; Bruning JC; Kahn CR; White MF; Accili D. 2000. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest 105(2):199-205. [PubMed: 10642598]  [MGI Ref ID J:59431]

Kido Y; Nakae J; Hribal ML; Xuan S; Efstratiadis A; Accili D. 2002. Effects of Mutations in the Insulin-like Growth Factor Signaling System on Embryonic Pancreas Development and beta -Cell Compensation to Insulin Resistance. J Biol Chem 277(39):36740-7. [PubMed: 12101187]  [MGI Ref ID J:79280]

Kim JJ; Kido Y; Scherer PE; White MF; Accili D. 2007. Analysis of compensatory beta-cell response in mice with combined mutations of Insr and Irs2. Am J Physiol Endocrinol Metab 292(6):E1694-701. [PubMed: 17299086]  [MGI Ref ID J:121915]

Kim JJ; Park BC; Kido Y; Accili D. 2001. Mitogenic and metabolic effects of type I IGF receptor overexpression in insulin receptor-deficient hepatocytes. Endocrinology 142(8):3354-60. [PubMed: 11459778]  [MGI Ref ID J:115605]

Kitamura T; Kido Y; Nef S; Merenmies J; Parada LF; Accili D. 2001. Preserved pancreatic beta-cell development and function in mice lacking the insulin receptor-related receptor. Mol Cell Biol 21(16):5624-30. [PubMed: 11463843]  [MGI Ref ID J:70602]

Kitamura T; Nakae J; Kitamura Y; Kido Y; Biggs WH 3rd; Wright CV; White MF; Arden KC; Accili D. 2002. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 110(12):1839-47. [PubMed: 12488434]  [MGI Ref ID J:80826]

Kulkarni RN; Almind K; Goren HJ; Winnay JN; Ueki K; Okada T; Kahn CR. 2003. Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice. Diabetes 52(6):1528-34. [PubMed: 12765966]  [MGI Ref ID J:83538]

Lauro D; Kido Y; Castle AL; Zarnowski MJ; Hayashi H; Ebina Y; Accili D. 1998. Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue [see comments] Nat Genet 20(3):294-8. [PubMed: 9806552]  [MGI Ref ID J:50589]

Liang L; Guo WH; Esquiliano DR; Asai M; Rodriguez S; Giraud J; Kushner JA; White MF; Lopez MF. 2010. Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. Endocrinology 151(2):741-7. [PubMed: 20032056]  [MGI Ref ID J:158405]

Lin HV; Accili D. 2011. Reconstitution of Insulin Action in Muscle, White Adipose Tissue, and Brain of Insulin Receptor Knock-out Mice Fails to Rescue Diabetes. J Biol Chem 286(11):9797-804. [PubMed: 21239487]  [MGI Ref ID J:170633]

Lin HV; Kim JY; Pocai A; Rossetti L; Shapiro L; Scherer PE; Accili D. 2007. Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout mice. Diabetes 56(8):1969-76. [PubMed: 17475934]  [MGI Ref ID J:126469]

Lin HV; Plum L; Ono H; Gutierrez-Juarez R; Shanabrough M; Borok E; Horvath TL; Rossetti L; Accili D. 2010. Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes 59(2):337-46. [PubMed: 19933998]  [MGI Ref ID J:164160]

Louvi A; Accili D; Efstratiadis A. 1997. Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development. Dev Biol 189(1):33-48. [PubMed: 9281335]  [MGI Ref ID J:42756]

Matsumoto M; Pocai A; Rossetti L; Depinho RA; Accili D. 2007. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor foxo1 in liver. Cell Metab 6(3):208-16. [PubMed: 17767907]  [MGI Ref ID J:129965]

Menghini R; Menini S; Amoruso R; Fiorentino L; Casagrande V; Marzano V; Tornei F; Bertucci P; Iacobini C; Serino M; Porzio O; Hribal ML; Folli F; Khokha R; Urbani A; Lauro R; Pugliese G; Federici M. 2009. Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice. Gastroenterology 136(2):663-72.e4. [PubMed: 19027012]  [MGI Ref ID J:145876]

Nakae J; Biggs WH; Kitamura T; Cavenee WK; Wright CV; Arden KC; Accili D. 2002. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet 32(2):245-53. [PubMed: 12219087]  [MGI Ref ID J:79560]

Nef S; Verma-Kurvari S; Merenmies J; Vassalli JD; Efstratiadis A; Accili D; Parada LF. 2003. Testis determination requires insulin receptor family function in mice. Nature 426(6964):291-5. [PubMed: 14628051]  [MGI Ref ID J:86618]

Nelson JF; Strong R; Bokov A; Diaz V; Ward W. 2012. Probing the relationship between insulin sensitivity and longevity using genetically modified mice. J Gerontol A Biol Sci Med Sci 67(12):1332-8. [PubMed: 23089336]  [MGI Ref ID J:190444]

Okamoto H; Hribal ML; Lin HV; Bennett WR; Ward A; Accili D. 2006. Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance. J Clin Invest 116(3):775-82. [PubMed: 16485043]  [MGI Ref ID J:106481]

Okamoto H; Nakae J; Kitamura T; Park BC; Dragatsis I; Accili D. 2004. Transgenic rescue of insulin receptor-deficient mice. J Clin Invest 114(2):214-23. [PubMed: 15254588]  [MGI Ref ID J:91350]

Okamoto H; Obici S; Accili D; Rossetti L. 2005. Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action. J Clin Invest 115(5):1314-1322. [PubMed: 15864351]  [MGI Ref ID J:98087]

Plum L; Lin HV; Aizawa KS; Liu Y; Accili D. 2012. InsR/FoxO1 signaling curtails hypothalamic POMC neuron number. PLoS One 7(2):e31487. [PubMed: 22319636]  [MGI Ref ID J:185235]

Senokuchi T; Liang CP; Seimon TA; Han S; Matsumoto M; Banks AS; Paik JH; DePinho RA; Accili D; Tabas I; Tall AR. 2008. Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress. Diabetes 57(11):2967-76. [PubMed: 18728232]  [MGI Ref ID J:142468]

Sukumar P; Viswambharan H; Imrie H; Cubbon RM; Yuldasheva N; Gage M; Galloway S; Skromna A; Kandavelu P; Santos CX; Gatenby VK; Smith J; Beech DJ; Wheatcroft SB; Channon KM; Shah AM; Kearney MT. 2013. Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction. Diabetes 62(6):2130-4. [PubMed: 23349484]  [MGI Ref ID J:208571]

Symons JD; McMillin SL; Riehle C; Tanner J; Palionyte M; Hillas E; Jones D; Cooksey RC; Birnbaum MJ; McClain DA; Zhang QJ; Gale D; Wilson LJ; Abel ED. 2009. Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure. Circ Res 104(9):1085-94. [PubMed: 19342603]  [MGI Ref ID J:164772]

Talchai C; Xuan S; Lin HV; Sussel L; Accili D. 2012. Pancreatic beta Cell Dedifferentiation as a Mechanism of Diabetic beta Cell Failure. Cell 150(6):1223-34. [PubMed: 22980982]  [MGI Ref ID J:187963]

Tanabe K; Liu Z; Patel S; Doble BW; Li L; Cras-Meneur C; Martinez SC; Welling CM; White MF; Bernal-Mizrachi E; Woodgett JR; Permutt MA. 2008. Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. PLoS Biol 6(2):e37. [PubMed: 18288891]  [MGI Ref ID J:135659]

Wertheimer E; Spravchikov N; Trebicz M; Gartsbein M; Accili D; Avinoah I; Nofeh-Moses S; Sizyakov G; Tennenbaum T. 2001. The regulation of skin proliferation and differentiation in the IR null mouse: implications for skin complications of diabetes. Endocrinology 142(3):1234-41. [PubMed: 11181540]  [MGI Ref ID J:68780]

Wheatcroft SB; Shah AM; Li JM; Duncan E; Noronha BT; Crossey PA; Kearney MT. 2004. Preserved glucoregulation but attenuation of the vascular actions of insulin in mice heterozygous for knockout of the insulin receptor. Diabetes 53(10):2645-52. [PubMed: 15448096]  [MGI Ref ID J:107184]

Xue B; Kim YB; Lee A; Toschi E; Bonner-Weir S; Kahn CR; Neel BG; Kahn BB. 2007. Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance. J Biol Chem 282(33):23829-40. [PubMed: 17545163]  [MGI Ref ID J:124807]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2140.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2782.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Wild-type from the colony
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.6)