Strain Name:

B6J x B6.C-H2-Kbm1/ByJ-Cdh23v-J/J

Stock Number:

002432

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6J x B6.C-H2bm1/ByJ-Cdh23v-J/J    (Changed: 24-APR-09 )
Type Coisogenic; Congenic; Major Histocompatibility Congenic; Mutant Stock; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Specieslaboratory mouse

Description
Mice homozygous for the waltzer Jackson spontaneous mutation (Cdh23v-J) exhibit the circling, head-tossing, deafness, and hyperactivity typical of circling mutants. Homozygous mutant mice are very similar to other waltzer mutants (Cdh23v and Cdh23v-2J). Most homozygotes are deaf from birth. Abnormalities of the inner ear include degeneration of the organ of Corti, spiral ganglion, stria vascularis, and saccular macula. Double heterozygotes with shaker-1 (Cdh23v/+ Myo7ash1/+) become deaf by 3 to 6 months of age. Double heterozygotes show degeneration in the organ of Corti, stria vascularis, and spiral ganglion similar to that of Cdh23v-J homozygotes, but less severe and with much later onset. Viability and breeding ability are somewhat reduced.

Related Strains

Strains carrying   H2-Kbm1 allele
000368   B6.C-H2-Kbm1/By
006559   B6.C-H2-Kbm1/ByBir-Gusbmps/BrkJ
000256   B6.C-H2-Kbm1/ByBir-Gusbmps/J
001060   B6.C-H2-Kbm1/ByJ
006558   B6.Cg-H2-Kbm1 Tg(GUSB)4Sly/SndsJ
View Strains carrying   H2-Kbm1     (5 strains)

Strains carrying other alleles of Cdh23
001137   129P1/ReJ
000690   129P3/J
000691   129X1/SvJ
000646   A/J
000647   A/WySnJ
003070   ALR/LtJ
003072   ALS/LtJ
002552   B6(V)-Cdh23v-2J/J
002756   B6.CAST-Cdh23Ahl+/Kjn
010615   B6.CBACa-Cdh23CBA/CaJ/Kjn
004502   B6;AKR-Lxl2/GrsrJ
001026   BALB/cByJ
000653   BUB/BnJ
005494   C3.129S1(B6)-Grm1rcw/J
000664   C57BL/6J
004764   C57BL/6J-Cdh23v-8J/J
004819   C57BL/6J-Cdh23v-9J/J
003129   C57BL/6J-Epha4rb-2J/GrsrJ
004820   C57BL/6J-Kcne12J/J
004703   C57BL/6J-Kcnq2Nmf134/J
004811   C57BL/6J-nmf110/J
004812   C57BL/6J-nmf111/J
004747   C57BL/6J-nmf118/J
004656   C57BL/6J-nmf88/J
004391   C57BL/6J-Chr 13A/J/NaJ
004385   C57BL/6J-Chr 7A/J/NaJ
000662   C57BLKS/J
000667   C57BR/cdJ
000668   C57L/J
000669   C58/J
010614   CBACa.B6-Cdh23ahl/Kjn
005016   CByJ;B6-Cdh23v-10J/J
000657   CE/J
000670   DBA/1J
001140   DBA/1LacJ
000671   DBA/2J
007048   DBA/2J-Gpnmb+/SjJ
002106   KK/HlJ
000675   LG/J
000676   LP/J
000677   MA/MyJ
001976   NOD/ShiLtJ
002050   NOR/LtJ
000679   P/J
002747   SENCARB/PtJ
002335   SKH2/J
003392   STOCK Crb1rd8/J
000275   V/LeJ
View Strains carrying other alleles of Cdh23     (48 strains)

View Strains carrying other alleles of H2-K     (13 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Usher Syndrome, Type ID; USH1D
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Deafness, Autosomal Recessive 12; DFNB12   (CDH23)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Cdh23v-J/Cdh23v-J

        B6.C-H2-Kbm1/ByJ
  • behavior/neurological phenotype
  • ataxia   (MGI Ref ID J:29159)
  • head tossing
    • vertical head tossing   (MGI Ref ID J:29159)
  • novel environmental response-related retropulsion
    • mice shuffle backwards when placed on a smooth surface   (MGI Ref ID J:29159)
  • hearing/vestibular/ear phenotype
  • abnormal otolith morphology
    • deficiencies in both utricular and saccular otoliths   (MGI Ref ID J:29159)
  • increased or absent threshold for auditory brainstem response
    • mice are deaf   (MGI Ref ID J:29159)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Cdh23v-J related

Developmental Biology Research
Defects in Cell Adhesion Molecules

Neurobiology Research
Hearing Defects
      deafness, nonsyndromic autosomal recessive 12 (DFNB12)

Sensorineural Research
Hearing Defects
      deafness, nonsyndromic autosomal recessive 12 (DFNB12)

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Cdh23v-J
Allele Name waltzer Jackson
Allele Type Spontaneous
Common Name(s) Bob; bobby; nm1971;
Strain of OriginB6.C-H2-Kbm1/ByJ
Gene Symbol and Name Cdh23, cadherin 23 (otocadherin)
Chromosome 10
Gene Common Name(s) 4930542A03Rik; CDHR23; RIKEN cDNA 4930542A03 gene; USH1D; W; age related hearing loss 1; ahl; bob; bobby; bus; bustling; mdfw; modifier of deaf waddler; neuroscience mutagenesis facility, 112; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; nmf112; nmf181; nmf252; sals; salsa; v; waltzer;
Molecular Note A single G residue at position 3560 was deleted in this allele. This mutation is predicted to cause a translational frame shift and premature termination of the encoded protein. [MGI Ref ID J:69985] [MGI Ref ID J:73941]
 
Allele Symbol H2-Kbm1
Allele Name b haplotype mutation 1
Allele Type Spontaneous
Common Name(s) H(z1); H-2ba; H-2bm1; Kbm1; bm1;
Strain of OriginBALB/cBy
Gene Symbol and Name H2-K, histocompatibility 2, K region
Chromosome 17
General Note Genbank ID for this allele: X56624
Molecular Note The bm1 mutation contains 7 nucleotide differences resulting in amino acid substitutions at codon 152 (glutamate to alanine), codon 155 (arginine to tyrosine) and codon 156 (leucine to tyrosine). [MGI Ref ID J:109263] [MGI Ref ID J:109268] [MGI Ref ID J:109270] [MGI Ref ID J:164061] [MGI Ref ID J:35731]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Bolz H; von Brederlow B; Ramirez A; Bryda EC; Kutsche K; Nothwang HG; Seeliger M; Cabrera Md; Vila MC; Molina OP; Kubisch C; Gal A. 2001. Mutation of CDH23, encoding a new member of the cadherin gene family, causes usher syndrome type 1D Nat Genet 27(1):108-12. [PubMed: 11138009]  [MGI Ref ID J:66740]

Cdh23v-J related

Di Palma F; Pellegrino R; Noben-Trauth K. 2001. Genomic structure, alternative splice forms and normal and mutant alleles of cadherin 23 (Cdh23). Gene 281(1-2):31-41. [PubMed: 11750125]  [MGI Ref ID J:73941]

Lutz CM; Cook S; Bronson RT; Erway L; Frankel WN. 1995. Remutation at the waltzer locus Mouse Genome 93(3):862.  [MGI Ref ID J:29159]

Manji SS; Miller KA; Williams LH; Andreasen L; Siboe M; Rose E; Bahlo M; Kuiper M; Dahl HH. 2011. An ENU-Induced Mutation of Cdh23 Causes Congenital Hearing Loss, but No Vestibular Dysfunction, in Mice. Am J Pathol 179(2):903-14. [PubMed: 21689626]  [MGI Ref ID J:174130]

Wilson SM; Householder DB; Coppola V; Tessarollo L; Fritzsch B; Lee EC; Goss D; Carlson GA; Copeland NG; Jenkins NA. 2001. Mutations in Cdh23 Cause Nonsyndromic Hearing Loss in waltzer Mice. Genomics 74(2):228-33. [PubMed: 11386759]  [MGI Ref ID J:69985]

H2-Kbm1 related

Agenes F; Dangy JP; Kirberg J. 2008. T cell receptor contact to restricting MHC molecules is a prerequisite for peripheral interclonal T cell competition. J Exp Med 205(12):2735-43. [PubMed: 19015305]  [MGI Ref ID J:141380]

Allison J; Stephens LA; Kay TW; Kurts C; Heath WR; Miller JF; Krummel MF. 1998. The threshold for autoimmune T cell killing is influenced by B7-1. Eur J Immunol 28(3):949-60. [PubMed: 9541590]  [MGI Ref ID J:134587]

Bailey DW; Snell GD; Cherry M. 1971. Complementation and Serolgical Analysis of an H-2 Mutant. In: Proc Symp Immunogenetics of the H-2 System, Liblice-Prague 1970. , Karger, Basel.  [MGI Ref ID J:164063]

Barouch-Bentov R; Lemmens EE; Hu J; Janssen EM; Droin NM; Song J; Schoenberger SP; Altman A. 2005. Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells. J Immunol 175(8):5126-34. [PubMed: 16210616]  [MGI Ref ID J:119122]

Behrens GM; Li M; Davey GM; Allison J; Flavell RA; Carbone FR; Heath WR. 2004. Helper requirements for generation of effector CTL to islet beta cell antigens. J Immunol 172(9):5420-6. [PubMed: 15100283]  [MGI Ref ID J:89639]

Benedict CA; Loewendorf A; Garcia Z; Blazar BR; Janssen EM. 2008. Dendritic Cell Programming by Cytomegalovirus Stunts Naive T Cell Responses via the PD-L1/PD-1 Pathway. J Immunol 180(7):4836-47. [PubMed: 18354207]  [MGI Ref ID J:133375]

Blazar BR; Carreno BM; Panoskaltsis-Mortari A; Carter L; Iwai Y; Yagita H; Nishimura H; Taylor PA. 2003. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J Immunol 171(3):1272-7. [PubMed: 12874215]  [MGI Ref ID J:120213]

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Brown GR; Thiele DL. 2000. Enhancement of MHC class I-stimulated alloresponses by TNF/TNF receptor (TNFR)1 interactions and of MHC class II-stimulated alloresponses by TNF/TNFR2 interactions Eur J Immunol 30(10):2900-7. [PubMed: 11069072]  [MGI Ref ID J:65234]

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Carroll LS; Penn DJ; Potts WK. 2002. Discrimination of MHC-derived odors by untrained mice is consistent with divergence in peptide-binding region residues. Proc Natl Acad Sci U S A 99(4):2187-92. [PubMed: 11842193]  [MGI Ref ID J:74764]

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Deguine J; Lee BL; Newman ZR; Barton GM. 2013. No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice. Nat Immunol 14(11):1101-2. [PubMed: 24145778]  [MGI Ref ID J:208727]

Drutman SB; Trombetta ES. 2010. Dendritic cells continue to capture and present antigens after maturation in vivo. J Immunol 185(4):2140-6. [PubMed: 20644175]  [MGI Ref ID J:162616]

Dyer CM; Zhan Y; Brady JL; Carbone FR; Smyth MJ; Lew AM. 2004. Unexpectedly, induction of cytotoxic T lymphocytes enhances the humoral response after DNA immunization. Blood 103(8):3073-5. [PubMed: 15070687]  [MGI Ref ID J:115473]

El-Hayek JM; Rogers TE; Brown GR. 2005. The role of TNF in hepatic histopathological manifestations and hepatic CD8+ T cell alloresponses in murine MHC class I disparate GVHD. J Leukoc Biol 78(4):1001-7. [PubMed: 16081594]  [MGI Ref ID J:101534]

Enouz S; Carrie L; Merkler D; Bevan MJ; Zehn D. 2012. Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection. J Exp Med 209(10):1769-79. [PubMed: 22987800]  [MGI Ref ID J:191273]

Erlebacher A; Vencato D; Price KA; Zhang D; Glimcher LH. 2007. Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus. J Clin Invest 117(5):1399-411. [PubMed: 17446933]  [MGI Ref ID J:122071]

Ford MS; Zhang ZX; Chen W; Zhang L. 2006. Double-negative T regulatory cells can develop outside the thymus and do not mature from CD8+ T cell precursors. J Immunol 177(5):2803-9. [PubMed: 16920915]  [MGI Ref ID J:139556]

Frischmeyer-Guerrerio PA; Montgomery RA; Warren DS; Cooke SK; Lutz J; Sonnenday CJ; Guerrerio AL; Dietz HC. 2011. Perturbation of thymocyte development in nonsense-mediated decay (NMD)-deficient mice. Proc Natl Acad Sci U S A 108(26):10638-43. [PubMed: 21670277]  [MGI Ref ID J:173551]

Gerard A; Khan O; Beemiller P; Oswald E; Hu J; Matloubian M; Krummel MF. 2013. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8(+) T cells. Nat Immunol 14(4):356-63. [PubMed: 23475183]  [MGI Ref ID J:194908]

Gerbitz A; Sukumar M; Helm F; Wilke A; Friese C; Fahrenwaldt C; Lehmann FM; Loddenkemper C; Kammertoens T; Mautner J; Schmitt CA; Blankenstein T; Bornkamm GW. 2012. Stromal interferon-gamma signaling and cross-presentation are required to eliminate antigen-loss variants of B cell lymphomas in mice. PLoS One 7(3):e34552. [PubMed: 22479645]  [MGI Ref ID J:187120]

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Prato S; Zhan Y; Mintern JD; Villadangos JA. 2013. Rapid deletion and inactivation of CTLs upon recognition of a number of target cells over a critical threshold. J Immunol 191(7):3534-44. [PubMed: 24018271]  [MGI Ref ID J:205935]

Robb RJ; Lineburg KE; Kuns RD; Wilson YA; Raffelt NC; Olver SD; Varelias A; Alexander KA; Teal BE; Sparwasser T; Hammerling GJ; Markey KA; Koyama M; Clouston AD; Engwerda CR; Hill GR; MacDonald KP. 2012. Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation. Blood 119(24):5898-908. [PubMed: 22538855]  [MGI Ref ID J:188644]

Rowe JH; Ertelt JM; Way SS. 2012. Innate IFN-gamma is essential for programmed death ligand-1-mediated T cell stimulation following Listeria monocytogenes infection. J Immunol 189(2):876-84. [PubMed: 22711893]  [MGI Ref ID J:189796]

Sancho D; Joffre OP; Keller AM; Rogers NC; Martinez D; Hernanz-Falcon P; Rosewell I; Reis e Sousa C. 2009. Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 458(7240):899-903. [PubMed: 19219027]  [MGI Ref ID J:147472]

Sato T; Ikeda M; Yotsumoto S; Shimada Y; Higuchi T; Kobayashi H; Fukuda T; Ohashi T; Suda T; Ohteki T. 2013. Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder. Blood 121(16):3267-73. [PubMed: 23412092]  [MGI Ref ID J:196707]

Schulze DH; Pease LR; Geier SS; Reyes AA; Sarmiento LA; Wallace RB; Nathenson SG. 1983. Comparison of the cloned H-2Kbm1 variant gene with the H-2Kb gene shows a cluster of seven nucleotide differences. Proc Natl Acad Sci U S A 80(7):2007-11. [PubMed: 6300887]  [MGI Ref ID J:109268]

Seillet C; Jackson JT; Markey KA; Brady HJ; Hill GR; Macdonald KP; Nutt SL; Belz GT. 2013. CD8alpha+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3. Blood 121(9):1574-83. [PubMed: 23297132]  [MGI Ref ID J:194760]

Selvaggi G; Ricordi C; Podack ER; Inverardi L. 1996. The role of the perforin and Fas pathways of cytotoxicity in skin graft rejection. Transplantation 62(12):1912-5. [PubMed: 8990386]  [MGI Ref ID J:37400]

Semmling V; Lukacs-Kornek V; Thaiss CA; Quast T; Hochheiser K; Panzer U; Rossjohn J; Perlmutter P; Cao J; Godfrey DI; Savage PB; Knolle PA; Kolanus W; Forster I; Kurts C. 2010. Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. Nat Immunol 11(4):313-20. [PubMed: 20190758]  [MGI Ref ID J:158986]

Serody JS; Burkett SE; Panoskaltsis-Mortari A; Ng-Cashin J; McMahon E; Matsushima GK; Lira SA; Cook DN; Blazar BR. 2000. T-lymphocyte production of macrophage inflammatory protein-1alpha is critical to the recruitment of CD8(+) T cells to the liver, lung, and spleen during graft-versus-host disease Blood 96(9):2973-80. [PubMed: 11049973]  [MGI Ref ID J:65501]

Serody JS; Cook DN; Kirby SL; Reap E; Shea TC; Frelinger JA. 1999. Murine T lymphocytes incapable of producing macrophage inhibitory protein-1 are impaired in causing graft-versus-host disease across a class I but not class II major histocompatibility complex barrier. Blood 93(1):43-50. [PubMed: 9864144]  [MGI Ref ID J:51842]

Sheng B; Odebralski JM; Smith RT. 1998. All or none peripheral tolerance induction in H-Y antigen-specific TCR transgenic mice. Transpl Immunol 6(2):78-83. [PubMed: 9777695]  [MGI Ref ID J:127670]

Shono Y; Ueha S; Wang Y; Abe J; Kurachi M; Matsuno Y; Sugiyama T; Nagasawa T; Imamura M; Matsushima K. 2010. Bone marrow graft-versus-host disease: early destruction of hematopoietic niche after MHC-mismatched hematopoietic stem cell transplantation. Blood 115(26):5401-11. [PubMed: 20354171]  [MGI Ref ID J:162817]

Shresta S; Graubert TA; Thomas DA; Raptis SZ; Ley TJ. 1999. Granzyme A initiates an alternative pathway for granule-mediated apoptosis. Immunity 10(5):595-605. [PubMed: 10367905]  [MGI Ref ID J:55398]

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Smyth LA; Ratnasothy K; Moreau A; Alcock S; Sagoo P; Meader L; Tanriver Y; Buckland M; Lechler R; Lombardi G. 2013. Tolerogenic Donor-Derived Dendritic Cells Risk Sensitization In Vivo owing to Processing and Presentation by Recipient APCs. J Immunol 190(9):4848-60. [PubMed: 23536635]  [MGI Ref ID J:195514]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery of Strains Needing Progeny Testing
    At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 10 and 14 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is no guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation.
    Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation.

    Please contact Customer Service for more information on the cost of progeny testing for a strain, tel: 1-800-422-6423 or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery of Strains Needing Progeny Testing
    At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 10 and 14 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is no guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation.
    Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation.

    Please contact Customer Service for more information on the cost of progeny testing for a strain, tel: 1-800-422-6423 or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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