Strain Name:

B6J x B6.C-H2-Kbm1/ByJ-Cdh23v-J/J

Stock Number:

002432

Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6J x B6.C-H2bm1/ByJ-Cdh23v-J/J    (Changed: 24-APR-09 )
Type Coisogenic; Congenic; Major Histocompatibility Congenic; Mutant Stock; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Generation+N1

Description
Mice homozygous for the waltzer Jackson spontaneous mutation (Cdh23v-J) exhibit the circling, head-tossing, deafness, and hyperactivity typical of circling mutants. Homozygous mutant mice are very similar to other waltzer mutants (Cdh23v and Cdh23v-2J). Most homozygotes are deaf from birth. Abnormalities of the inner ear include degeneration of the organ of Corti, spiral ganglion, stria vascularis, and saccular macula. Double heterozygotes with shaker-1 (Cdh23v/+ Myo7ash1/+) become deaf by 3 to 6 months of age. Double heterozygotes show degeneration in the organ of Corti, stria vascularis, and spiral ganglion similar to that of Cdh23v-J homozygotes, but less severe and with much later onset. Viability and breeding ability are somewhat reduced.

Related Strains

Strains carrying   H2-Kbm1 allele
000368   B6.C-H2-Kbm1/By
006559   B6.C-H2-Kbm1/ByBir-Gusbmps/BrkJ
000256   B6.C-H2-Kbm1/ByBir-Gusbmps/J
001060   B6.C-H2-Kbm1/ByJ
006558   B6.Cg-H2-Kbm1 Tg(GUSB)4Sly/SndsJ
View Strains carrying   H2-Kbm1     (5 strains)

Strains carrying other alleles of Cdh23
001137   129P1/ReJ
000690   129P3/J
000691   129X1/SvJ
000646   A/J
000647   A/WySnJ
003070   ALR/LtJ
003072   ALS/LtJ
002756   B6.CAST-Cdh23Ahl+/Kjn
004502   B6;AKR-Lxl2/GrsrJ
001026   BALB/cByJ
000653   BUB/BnJ
005494   C3.129S1(B6)-Grm1rcw/J
000664   C57BL/6J
002552   C57BL/6J-Cdh23v-2J/J
004764   C57BL/6J-Cdh23v-8J/J
004819   C57BL/6J-Cdh23v-9J/J
003129   C57BL/6J-Epha4rb-2J/GrsrJ
004820   C57BL/6J-Kcne12J/J
004703   C57BL/6J-Kcnq2Nmf134/J
004811   C57BL/6J-nmf110/J
004812   C57BL/6J-nmf111/J
004747   C57BL/6J-nmf118/J
004656   C57BL/6J-nmf88/J
004391   C57BL/6J-Chr 13A/J/NaJ
004385   C57BL/6J-Chr 7A/J/NaJ
000662   C57BLKS/J
000667   C57BR/cdJ
000668   C57L/J
000669   C58/J
005016   CByJ;B6-Cdh23v-10J/J
000657   CE/J
000670   DBA/1J
001140   DBA/1LacJ
000671   DBA/2J
007048   DBA/2J-Gpnmb+/SjJ
002106   KK/HlJ
000675   LG/J
000676   LP/J
000677   MA/MyJ
001976   NOD/ShiLtJ
002050   NOR/LtJ
000679   P/J
002747   SENCARB/PtJ
002335   SKH2/J
003392   STOCK Crb1rd8/J
000275   V/LeJ
View Strains carrying other alleles of Cdh23     (46 strains)

View Strains carrying other alleles of H2-K     (5 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Cdh23v-J/Cdh23+

        B6.C-H2-Kbm1/ByJ
  • no phenotypic analysis
  • *normal* no phenotypic analysis (MGI Ref ID J:73941)
    • no phenotypic data is available
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Cdh23v-J related

Developmental Biology Research
Defects in Cell Adhesion Molecules

Mouse/Human Gene Homologs
Usher syndrome, type ID
      USH1D
deafness, autosomal recessive 12 (DFNB12)

Neurobiology Research
Vestibular and Hearing Defects
      deafness, nonsyndromic autosomal recessive 12 (DFNB12)

Sensorineural Research
Vestibular and Hearing Defects
      deafness, nonsyndromic autosomal recessive 12 (DFNB12)

Genes & Alleles

Gene & Allele Information

 
Allele Symbol Cdh23v-J
Allele Name waltzer Jackson
Allele Type Spontaneous
Common Name(s) Bob; bobby; nm1971;
Strain of OriginB6.C-H2-Kbm1/ByJ
Gene Symbol and Name Cdh23, cadherin 23 (otocadherin)
Chromosome 10
Gene Common Name(s) 4930542A03Rik; DFNB12; DKFZp434P2350; FLJ00233; FLJ36499; KIAA1774; KIAA1812; MGC102761; RIKEN cDNA 4930542A03 gene; USH1D; W; age related hearing loss 1; ahl; bob; bobby; bus; bustling; mdfw; modifier of deaf waddler; neuroscience mutagenesis facility, 112; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; nmf112; nmf181; nmf252; sals; salsa; v; waltzer;
Molecular Note A single G residue at position 3560 was deleted in this allele. This mutation is predicted to cause a translational frame shift and premature termination of the encoded protein. [MGI Ref ID J:69985] [MGI Ref ID J:73941]
 
Allele Symbol H2-Kbm1
Allele Name b haplotype mutation 1
Allele Type Spontaneous
Common Name(s) H(z1); H-2ba; H-2bm1; Kbm1; bm1;
Strain of OriginBALB/cBy
Gene Symbol and Name H2-K, histocompatibility 2, K region
Chromosome 17
General Note Genbank ID for this allele: X56624
Molecular Note The bm1 mutation contains 7 nucleotide differences resulting in amino acid substitutions at codon 152 (glutamate to alanine), codon 155 (arginine to tyrosine) and codon 156 (leucine to tyrosine). [MGI Ref ID J:109263] [MGI Ref ID J:109268] [MGI Ref ID J:109270]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Additional References

Bolz H; von Brederlow B; Ramirez A; Bryda EC; Kutsche K; Nothwang HG; Seeliger M; Cabrera Md; Vila MC; Molina OP; Kubisch C; Gal A. 2001. Mutation of CDH23, encoding a new member of the cadherin gene family, causes usher syndrome type 1D Nat Genet 27(1):108-12. [PubMed: 11138009]  [MGI Ref ID J:66740]

Cdh23v-J related

Di Palma F; Pellegrino R; Noben-Trauth K. 2001. Genomic structure, alternative splice forms and normal and mutant alleles of cadherin 23 (Cdh23). Gene 281(1-2):31-41. [PubMed: 11750125]  [MGI Ref ID J:73941]

Lutz CM; Cook S; Bronson RT; Erway L; Frankel WN. 1995. Remutation at the waltzer locus Mouse Genome 93(3):862.  [MGI Ref ID J:29159]

Wilson SM; Householder DB; Coppola V; Tessarollo L; Fritzsch B; Lee EC; Goss D; Carlson GA; Copeland NG; Jenkins NA. 2001. Mutations in Cdh23 Cause Nonsyndromic Hearing Loss in waltzer Mice. Genomics 74(2):228-33. [PubMed: 11386759]  [MGI Ref ID J:69985]

H2-Kbm1 related

Agenes F; Dangy JP; Kirberg J. 2008. T cell receptor contact to restricting MHC molecules is a prerequisite for peripheral interclonal T cell competition. J Exp Med 205(12):2735-43. [PubMed: 19015305]  [MGI Ref ID J:141380]

Allison J; Stephens LA; Kay TW; Kurts C; Heath WR; Miller JF; Krummel MF. 1998. The threshold for autoimmune T cell killing is influenced by B7-1. Eur J Immunol 28(3):949-60. [PubMed: 9541590]  [MGI Ref ID J:134587]

Barouch-Bentov R; Lemmens EE; Hu J; Janssen EM; Droin NM; Song J; Schoenberger SP; Altman A. 2005. Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells. J Immunol 175(8):5126-34. [PubMed: 16210616]  [MGI Ref ID J:119122]

Behrens GM; Li M; Davey GM; Allison J; Flavell RA; Carbone FR; Heath WR. 2004. Helper requirements for generation of effector CTL to islet beta cell antigens. J Immunol 172(9):5420-6. [PubMed: 15100283]  [MGI Ref ID J:89639]

Benedict CA; Loewendorf A; Garcia Z; Blazar BR; Janssen EM. 2008. Dendritic Cell Programming by Cytomegalovirus Stunts Naive T Cell Responses via the PD-L1/PD-1 Pathway. J Immunol 180(7):4836-47. [PubMed: 18354207]  [MGI Ref ID J:133375]

Blazar BR; Carreno BM; Panoskaltsis-Mortari A; Carter L; Iwai Y; Yagita H; Nishimura H; Taylor PA. 2003. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J Immunol 171(3):1272-7. [PubMed: 12874215]  [MGI Ref ID J:120213]

Bluestone JA; McKenzie IF; Melvold RW; Ozato K; Sandrin MS; Sharrow SO; Sachs DH. 1984. Serological analysis of H-2 mutations using monoclonal antibodies. J Immunogenet 11(3-4):197-207. [PubMed: 6084033]  [MGI Ref ID J:98121]

Bolinger B; Krebs P; Tian Y; Engeler D; Scandella E; Miller S; Palmer DC; Restifo NP; Clavien PA; Ludewig B. 2008. Immunologic ignorance of vascular endothelial cells expressing minor histocompatibility antigen. Blood 111(9):4588-95. [PubMed: 18195091]  [MGI Ref ID J:134363]

Brown GR; Thiele DL. 2000. Enhancement of MHC class I-stimulated alloresponses by TNF/TNF receptor (TNFR)1 interactions and of MHC class II-stimulated alloresponses by TNF/TNFR2 interactions Eur J Immunol 30(10):2900-7. [PubMed: 11069072]  [MGI Ref ID J:65234]

Brown RE; Schellinck HM; Jagosh J. 1998. Behavioural studies of MHC-congenic mice. Genetica 104(3):249-57. [PubMed: 10386391]  [MGI Ref ID J:55290]

Carroll LS; Penn DJ; Potts WK. 2002. Discrimination of MHC-derived odors by untrained mice is consistent with divergence in peptide-binding region residues. Proc Natl Acad Sci U S A 99(4):2187-92. [PubMed: 11842193]  [MGI Ref ID J:74764]

Dyer CM; Zhan Y; Brady JL; Carbone FR; Smyth MJ; Lew AM. 2004. Unexpectedly, induction of cytotoxic T lymphocytes enhances the humoral response after DNA immunization. Blood 103(8):3073-5. [PubMed: 15070687]  [MGI Ref ID J:115473]

El-Hayek JM; Rogers TE; Brown GR. 2005. The role of TNF in hepatic histopathological manifestations and hepatic CD8+ T cell alloresponses in murine MHC class I disparate GVHD. J Leukoc Biol 78(4):1001-7. [PubMed: 16081594]  [MGI Ref ID J:101534]

Erlebacher A; Vencato D; Price KA; Zhang D; Glimcher LH. 2007. Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus. J Clin Invest 117(5):1399-411. [PubMed: 17446933]  [MGI Ref ID J:122071]

Ford MS; Zhang ZX; Chen W; Zhang L. 2006. Double-negative T regulatory cells can develop outside the thymus and do not mature from CD8+ T cell precursors. J Immunol 177(5):2803-9. [PubMed: 16920915]  [MGI Ref ID J:139556]

Graubert TA; DiPersio JF; Russell JH; Ley TJ. 1997. Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation. J Clin Invest 100(4):904-11. [PubMed: 9259590]  [MGI Ref ID J:42355]

Hammer GE; Gonzalez F; James E; Nolla H; Shastri N. 2007. In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides. Nat Immunol 8(1):101-8. [PubMed: 17128277]  [MGI Ref ID J:116606]

Hofling AA; Vogler C; Creer MH; Sands MS. 2003. Engraftment of human CD34+ cells leads to widespread distribution of donor-derived cells and correction of tissue pathology in a novel murine xenotransplantation model of lysosomal storage disease. Blood 101(5):2054-63. [PubMed: 12406886]  [MGI Ref ID J:109848]

Hogquist KA; Jameson SC; Heath WR; Howard JL; Bevan MJ; Carbone FR. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76(1):17-27. [PubMed: 8287475]  [MGI Ref ID J:92867]

Huygen K; Drowart A; Harboe M; ten Berg R; Cogniaux J; Van Vooren JP. 1993. Influence of genes from the major histocompatibility complex on the antibody repertoire against culture filtrate antigens in mice infected with live Mycobacterium bovis BCG. Infect Immun 61(6):2687-93. [PubMed: 8500908]  [MGI Ref ID J:13022]

Kassiotis G; Garcia S; Simpson E; Stockinger B. 2002. Impairment of immunological memory in the absence of MHC despite survival of memory T cells. Nat Immunol 3(3):244-50. [PubMed: 11836529]  [MGI Ref ID J:151747]

Kievits F; Lokhorst W; Ivanyi P. 1990. Abnormal anti-viral immune response in mice is corrected in HLA-B27.2-transgenic mice. Eur J Immunol 20(5):1189-92. [PubMed: 1694133]  [MGI Ref ID J:128764]

Kirberg J; Bosco N; Deloulme JC; Ceredig R; Agenes F. 2008. Peripheral T lymphocytes recirculating back into the thymus can mediate thymocyte positive selection. J Immunol 181(2):1207-14. [PubMed: 18606674]  [MGI Ref ID J:137464]

Klein J; Figueroa F; David CS. 1983. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex. Immunogenetics 17(6):553-96. [PubMed: 6407984]  [MGI Ref ID J:7097]

Lamouse-Smith E; McCarthy SA. 1997. Allospecific cytotoxic T cells generated from beta 2m-/- mice in primary MLC: analysis of activation requirements, specificity, and phenotype. Cell Immunol 179(2):107-15. [PubMed: 9268494]  [MGI Ref ID J:42696]

Le Borgne M; Etchart N; Goubier A; Lira SA; Sirard JC; van Rooijen N; Caux C; Ait-Yahia S; Vicari A; Kaiserlian D; Dubois B. 2006. Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo. Immunity 24(2):191-201. [PubMed: 16473831]  [MGI Ref ID J:113330]

Leibnitz RR; Lipsky PE; Thiele DL. 1995. Protection from T helper cell-mediated graft-versus-host disease by the presence of an MHC class I alloantigen is associated with perturbation of MHC class II-restricted responses by class I-derived peptides. J Immunol 155(4):1784-95. [PubMed: 7636234]  [MGI Ref ID J:28656]

Ljunggren HG; Van Kaer L; Sabatine MS; Auchincloss H Jr; Tonegawa S; Ploegh HL. 1995. MHC class I expression and CD8+ T cell development in TAP1/beta 2-microglobulin double mutant mice. Int Immunol 7(6):975-84. [PubMed: 7577806]  [MGI Ref ID J:26520]

MGD Nomenclature Committee. 1995. :.  [MGI Ref ID J:23000]

Maeda Y; Reddy P; Lowler KP; Liu C; Bishop DK; Ferrara JL. 2005. Critical role of host gammadelta T cells in experimental acute graft-versus-host disease. Blood 106(2):749-55. [PubMed: 15797996]  [MGI Ref ID J:107458]

McKenzie IF; Morgan GM; Blanden RV; Melvold R; Kohn H. 1977. Studies of H-2 mutations in C57BL/6 and BALB/c mice. Transplant Proc 9(1):551-3. [PubMed: 68588]  [MGI Ref ID J:109278]

Melvold RW; Wang K; Kohn HI. 1997. Histocompatibility gene mutation rates in the mouse: a 25-year review. Immunogenetics 47(1):44-54. [PubMed: 9382920]  [MGI Ref ID J:44711]

Miyada CG; Klofelt C; Reyes AA; McLaughlin-Taylor E; Wallace RB. 1985. Evidence that polymorphism in the murine major histocompatibility complex may be generated by the assortment of subgene sequences. Proc Natl Acad Sci U S A 82(9):2890-4. [PubMed: 2581256]  [MGI Ref ID J:109270]

Mohiuddin M; Ruggiero V; Shen Z; DiSesa VJ. 1996. T-cell receptor expression in C57BL/6 mice that reject or are rendered tolerant to bm1 cardiac grafts. J Thorac Cardiovasc Surg 112(2):310-3. [PubMed: 8751496]  [MGI Ref ID J:35731]

Newberg MH; Smith DH; Haertel SB; Vining DR; Lacy E; Engelhard VH. 1996. Importance of MHC class 1 alpha2 and alpha3 domains in the recognition of self and non-self MHC molecules. J Immunol 156(7):2473-80. [PubMed: 8786307]  [MGI Ref ID J:31937]

Ohlemiller KK; Hennig AK; Lett JM; Heidbreder AF; Sands MS. 2002. Inner ear pathology in the mucopolysaccharidosis VII mouse. Hear Res 169(1-2):69-84. [PubMed: 12121741]  [MGI Ref ID J:108876]

Pease LR; Schulze DH; Pfaffenbach GM; Nathenson SG. 1983. Spontaneous H-2 mutants provide evidence that a copy mechanism analogous to gene conversion generates polymorphism in the major histocompatibility complex. Proc Natl Acad Sci U S A 80(1):242-6. [PubMed: 6571997]  [MGI Ref ID J:109263]

Sancho D; Joffre OP; Keller AM; Rogers NC; Martinez D; Hernanz-Falcon P; Rosewell I; Reis e Sousa C. 2009. Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 458(7240):899-903. [PubMed: 19219027]  [MGI Ref ID J:147472]

Schulze DH; Pease LR; Geier SS; Reyes AA; Sarmiento LA; Wallace RB; Nathenson SG. 1983. Comparison of the cloned H-2Kbm1 variant gene with the H-2Kb gene shows a cluster of seven nucleotide differences. Proc Natl Acad Sci U S A 80(7):2007-11. [PubMed: 6300887]  [MGI Ref ID J:109268]

Selvaggi G; Ricordi C; Podack ER; Inverardi L. 1996. The role of the perforin and Fas pathways of cytotoxicity in skin graft rejection. Transplantation 62(12):1912-5. [PubMed: 8990386]  [MGI Ref ID J:37400]

Serody JS; Burkett SE; Panoskaltsis-Mortari A; Ng-Cashin J; McMahon E; Matsushima GK; Lira SA; Cook DN; Blazar BR. 2000. T-lymphocyte production of macrophage inflammatory protein-1alpha is critical to the recruitment of CD8(+) T cells to the liver, lung, and spleen during graft-versus-host disease Blood 96(9):2973-80. [PubMed: 11049973]  [MGI Ref ID J:65501]

Serody JS; Cook DN; Kirby SL; Reap E; Shea TC; Frelinger JA. 1999. Murine T lymphocytes incapable of producing macrophage inhibitory protein-1 are impaired in causing graft-versus-host disease across a class I but not class II major histocompatibility complex barrier. Blood 93(1):43-50. [PubMed: 9864144]  [MGI Ref ID J:51842]

Sheng B; Odebralski JM; Smith RT. 1998. All or none peripheral tolerance induction in H-Y antigen-specific TCR transgenic mice. Transpl Immunol 6(2):78-83. [PubMed: 9777695]  [MGI Ref ID J:127670]

Shresta S; Graubert TA; Thomas DA; Raptis SZ; Ley TJ. 1999. Granzyme A initiates an alternative pathway for granule-mediated apoptosis. Immunity 10(5):595-605. [PubMed: 10367905]  [MGI Ref ID J:55398]

Shulz M; Schuurman HJ; Joergensen J; Steiner C; Meerloo T; Kagi D; Hengartner H; Schreier MH; Burki K; Ledermann B. 1995. Acute rejection of vascular heart allografts by perforin- deficient mice. Eur J Immunol 25(2):474-480. [PubMed: 7533086]  [MGI Ref ID J:23268]

Sim BC; Travers PJ; Gascoigne NR. 1997. V alpha 3.2 selection in MHC class I mutant mice: evidence for an alternate orientation of TCR-MHC class I interaction. J Immunol 159(7):3322-9. [PubMed: 9317130]  [MGI Ref ID J:127052]

Spielman J; Lee RK; Podack ER. 1998. Perforin/Fas-ligand double deficiency is associated with macrophage expansion and severe pancreatitis. J Immunol 161(12):7063-70. [PubMed: 9862744]  [MGI Ref ID J:112121]

Zhan Y; Bourges D; Dromey JA; Harrison LC; Lew AM. 2007. The origin of thymic CD4+CD25+ regulatory T cells and their co-stimulatory requirements are determined after elimination of recirculating peripheral CD4+ cells. Int Immunol 19(4):455-63. [PubMed: 17314081]  [MGI Ref ID J:119986]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Price (US dollars $)
Cryorecovery Fee $1900.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Price (US dollars $)
Cryorecovery Fee $2470.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

Supply Details

Standard SupplyCryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery of Strains Needing Progeny Testing.
    At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 13 and 16 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks.

    Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 (from U.S.A., Canada and Puerto Rico only) or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

  • Genomic DNA is available for this strain from the Mouse DNA Resource.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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