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The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names C3.129P2(B6)-B2mtm1Unc    (Changed: 15-DEC-04 )
Type Congenic; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C3H/HeJ
Donor Strain B6;129P-B2mtm1Unc (129P2 derived E14TG2a ES cell line)
Donating InvestigatorDr. Derry Roopenian,   The Jackson Laboratory

Related Genotype: A/A

Important Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.

Mice homozygous for the B2mtm1Unc targeted mutation have little if any MHC class I protein expression on the cell surface. There are few CD8+ cytotoxic T-cells and under some circumstances a compensatory increase in CD4+ cytotoxic T-cells. Immune responses involving CD8+T-cells are severely deficient providing a model to assess the role of CD8+ cells and class I MHC in various experimental systems. Hemachromatosis has been noted in certain genetic backgrounds (Rothenberg BE, Voland JR, Proc Natl Acad Sci USA 93:1529-34, 1996). In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

The B2mtm1Unc mutant strain was developed in the laboratory of Dr. Beverly Koller and Dr. Oliver Smithies at the University of North Carolina at Chapel Hill. It was generated by a targeted disruption of the B2m gene. The 129-derived E14TG2a ES cell line was used. The C3H/HeJ strain was produced in the laboratory of Dr. Derry Roopenian at The Jackson Laboratory by backcrossing the B2mtm1Unc mutation 10 times to C3H/HeJ inbred mice.

Control Information

   000659 C3H/HeJ
  Considerations for Choosing Controls

Related Strains

View Strains carrying   B2mtm1Unc     (21 strains)

Strains carrying   Pde6brd1 allele
004202   B6.C3 Pde6brd1 Hps4le/+ +-Lmx1adr-8J/J
000002   B6.C3-Pde6brd1 Hps4le/J
001022   B6C3FeF1/J a/a
000652   BDP/J
000653   BUB/BnJ
005494   C3.129S1(B6)-Grm1rcw/J
000509   C3.Cg-Lystbg-2J/J
000480   C3.MRL-Faslpr/J
001957   C3A Pde6brd1.O20/A-Prph2Rd2/J
004326   C3Bir.129P2(B6)-Il10tm1Cgn/Lt
003968   C3Bir.129P2(B6)-Il10tm1Cgn/LtJ
006435   C3Fe.SW-Soaa/MonJ
001904   C3H-Atcayji-hes/J
000659   C3H/HeJ
000511   C3H/HeJ-Ap3d1mh-2J/J
000784   C3H/HeJ-Faslgld/J
002433   C3H/HeJ-Sptbn4qv-lnd2J/J
005972   C3H/HeJBirLtJ
001824   C3H/HeJSxJ
000635   C3H/HeOuJ
000474   C3H/HeSn
001431   C3H/HeSn-ocd/J
000661   C3H/HeSnJ
002333   C3H/HeSnJ-gri/J
001576   C3He-Atp7btx-J/J
000658   C3HeB/FeJ
002588   C3HeB/FeJ-Eya1bor/J
001533   C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J
001908   C3HfB/BiJ
001502   C3Sn.B6-Epha4rb/EiGrsrJ
002235   C3Sn.C3-Ctnna2cdf/J
001547   C3Sn.Cg-Cm/J
001906   C3fBAnl.Cg-Catb/AnlJ
000656   CBA/J
000813   CBA/J-Atp7aMo-pew/J
000660   DA/HuSnJ
000023   FL/1ReJ
000025   FL/4ReJ
003024   FVB.129P2(B6)-Fmr1tm1Cgr/J
002539   FVB.129P2-Abcb4tm1Bor/J
002935   FVB.129S2(B6)-Ccnd1tm1Wbg/J
002953   FVB.Cg-Tg(MMTVTGFA)254Rjc/J
003170   FVB.Cg-Tg(Myh6-tTA)6Smbf/J
003078   FVB.Cg-Tg(WapIgf1)39Dlr/J
003487   FVB.Cg-Tg(XGFAP-lacZ)3Mes/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
002384   FVB/N-Tg(UcpDta)1Kz/J
001800   FVB/NJ
001491   FVB/NMob
000804   HPG/BmJ
000734   MOLD/RkJ
000550   MOLF/EiJ
002423   NON/ShiLtJ
000679   P/J
000680   PL/J
000268   RSV/LeJ
000269   SB/LeJ
010968   SB;C3Sn-Lrp4mdig-2J/GrsrJ
005651   SJL.AK-Thy1a/TseJ
000686   SJL/J
000688   ST/bJ
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
002648   STOCK a/a Cln6nclf/J
000279   STOCK gr +/+ Ap3d1mh/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
004770   SW.B6-Soab/J
002023   SWR.M-Emv21 Emv22/J
000689   SWR/J
000939   SWR/J-Clcn1adr-mto/J
000692   WB/ReJ KitW/J
100410   WBB6F1/J-KitW/KitW-v/J
000693   WC/ReJ KitlSl/J
View Strains carrying   Pde6brd1     (73 strains)

Strains carrying other alleles of B2m
000422   B10.LP-H3b H13b/(36NS)Sn
000421   B10.LP-H3b/Sn
002571   NOD.Cg Prkdcscid-B2mb/Dvs
008542   NOD.Cg-B2mtm1Unc Tg(GFAP-B2m)9Mdos/J
View Strains carrying other alleles of B2m     (4 strains)

View Strains carrying other alleles of Pde6b     (15 strains)


Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Hypoproteinemia, Hypercatabolic   (B2M)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.


        involves: 129P2/OlaHsd * C57BL/6
  • immune system phenotype
  • decreased CD8-positive, alpha-beta T cell number
    • numbers of CD8+CD4- T cells from the thymus of five week old mice are reduced in comparison to control (4.9% vs. 6.7%), however, in peripheral lymphoid tissues numbers of CD8+CD4- T cells do not differ from control   (MGI Ref ID J:64451)
  • decreased level of surface class I molecules
    • surface expression of class I molecules in cells from lymph nodes are reduced in comparison to control   (MGI Ref ID J:64451)
  • hematopoietic system phenotype
  • decreased CD8-positive, alpha-beta T cell number
    • numbers of CD8+CD4- T cells from the thymus of five week old mice are reduced in comparison to control (4.9% vs. 6.7%), however, in peripheral lymphoid tissues numbers of CD8+CD4- T cells do not differ from control   (MGI Ref ID J:64451)


        involves: 129P2/OlaHsd * C57BL/6
  • immune system phenotype
  • abnormal T cell number
    • mucosal-associated invariant T cells (MAIT) that express the canonical mVa19-Ja33 TCR rearrangement and are typically found in the gut lamina propia are virtually absent in these mice   (MGI Ref ID J:113083)
    • when wild-type bone marrow is transferred into these mice, MAIT T cells are found in the gut   (MGI Ref ID J:113083)
    • when these mice serve as bone marrow donors, MAIT T cells are absent in the gut of irradiated hosts   (MGI Ref ID J:113083)
    • absent CD8-positive, alpha-beta T cells
      • deficient in CD4-CD8+ T cells   (MGI Ref ID J:64451)
      • CD8+CD4- T cells from the thymus of five week old mice are almost non-existent in comparison to control (0.8% vs. 6.7%), however, total numbers of alpha beta T cells and CD8-CD4+ T cells do not differ significantly from control   (MGI Ref ID J:64451)
  • decreased level of surface class I molecules
    • surface expression of class I molecules in cells from lymph nodes, spleen and thymus cannot be detected by flow cytometry   (MGI Ref ID J:64451)
  • hematopoietic system phenotype
  • abnormal T cell number
    • mucosal-associated invariant T cells (MAIT) that express the canonical mVa19-Ja33 TCR rearrangement and are typically found in the gut lamina propia are virtually absent in these mice   (MGI Ref ID J:113083)
    • when wild-type bone marrow is transferred into these mice, MAIT T cells are found in the gut   (MGI Ref ID J:113083)
    • when these mice serve as bone marrow donors, MAIT T cells are absent in the gut of irradiated hosts   (MGI Ref ID J:113083)
    • absent CD8-positive, alpha-beta T cells
      • deficient in CD4-CD8+ T cells   (MGI Ref ID J:64451)
      • CD8+CD4- T cells from the thymus of five week old mice are almost non-existent in comparison to control (0.8% vs. 6.7%), however, total numbers of alpha beta T cells and CD8-CD4+ T cells do not differ significantly from control   (MGI Ref ID J:64451)


  • mortality/aging
  • increased susceptibility to infection induced morbidity/mortality
    • following infection with either a low or high dose of IOE, 90% of mice survive a low dose and all mice succumb to a high dose   (MGI Ref ID J:123934)
  • immune system phenotype
  • abnormal interleukin level
    • following infection with a lethal low dose of a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), induces less IL-10 than in infected wild-type mice   (MGI Ref ID J:123934)
  • abnormal tumor necrosis factor level
    • following infection with a lethal low dose of a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), induces less TNF-alpha than in infected wild-type mice   (MGI Ref ID J:123934)
  • decreased CD8-positive, alpha-beta T cell number
    • following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), CD8+ T cells in the spleen are reduced (1.5%+/-0.1% of splenocytes compared to 9.7%+/-0.7% of splenocytes in wild-type mice)   (MGI Ref ID J:123934)
    • in uninfected mice the number of CD8+ T cells in the spleen is reduced compared to in wild-type mice   (MGI Ref ID J:123934)
  • decreased IgG level   (MGI Ref ID J:110885)
  • decreased susceptibility to autoimmune diabetes
    • mice do not develop spontaneous diabetes compared to wild-type NOD controls   (MGI Ref ID J:135214)
    • when splenocytes from diabetic donors are transferred into lethally-irradiated 8-week old recipients, female mice remain normoglycemic for about 17 weeks before developing hyperglycemia/diabetes; kinetics are much slower than in B2m-null, Tg(GFAP-B2m)Mdos (line 9 or 14) transgenic mice   (MGI Ref ID J:135214)
  • decreased susceptibility to bacterial infection
    • mice are highly resistant to infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE) following infection with either a low or high dose of IOE, 90% of mice survive a low dose with mild illness and all mice succumb to a high doseto a high dose   (MGI Ref ID J:123934)
    • following infection with IEO, CD8+ T cells in the spleen are reduced (1.5%+/-0.1% of splenocytes compared to 9.7%+/-0.7% of splenocytes in wild-type mice)   (MGI Ref ID J:123934)
    • mice have lower burdens of Ehrlichia bacteria in the lungs and spleen following infection than do wild-type mice   (MGI Ref ID J:123934)
    • at day 12 and 14 post-infection with a lethal low dose of IEO, mice exhibit only mild liver pathology, few apoptotic foci in the liver and preserved lymphoid tissue cellularity   (MGI Ref ID J:123934)
  • increased IgM level   (MGI Ref ID J:110885)
  • increased T-helper 1 cell number
    • following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), the number of interferon-gamma producing CD4+ Th1 cells in the spleen on day 8 and day 12 is increased relative to in infected wild-type mice   (MGI Ref ID J:123934)
  • increased susceptibility to infection induced morbidity/mortality
    • following infection with either a low or high dose of IOE, 90% of mice survive a low dose and all mice succumb to a high dose   (MGI Ref ID J:123934)
  • hematopoietic system phenotype
  • decreased CD8-positive, alpha-beta T cell number
    • following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), CD8+ T cells in the spleen are reduced (1.5%+/-0.1% of splenocytes compared to 9.7%+/-0.7% of splenocytes in wild-type mice)   (MGI Ref ID J:123934)
    • in uninfected mice the number of CD8+ T cells in the spleen is reduced compared to in wild-type mice   (MGI Ref ID J:123934)
  • decreased IgG level   (MGI Ref ID J:110885)
  • increased IgM level   (MGI Ref ID J:110885)
  • increased T-helper 1 cell number
    • following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), the number of interferon-gamma producing CD4+ Th1 cells in the spleen on day 8 and day 12 is increased relative to in infected wild-type mice   (MGI Ref ID J:123934)
  • endocrine/exocrine gland phenotype
  • abnormal pancreas morphology
    • mice develop peri-islet T cell aggregates >30 weeks of age   (MGI Ref ID J:135214)
  • homeostasis/metabolism phenotype
  • abnormal interleukin level
    • following infection with a lethal low dose of a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), induces less IL-10 than in infected wild-type mice   (MGI Ref ID J:123934)
  • abnormal tumor necrosis factor level
    • following infection with a lethal low dose of a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), induces less TNF-alpha than in infected wild-type mice   (MGI Ref ID J:123934)
  • decreased circulating serum albumin level   (MGI Ref ID J:110885)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

B2mtm1Unc related

Hematological Research
Anemia, Iron Deficiency and Transport Defects

Immunology, Inflammation and Autoimmunity Research
      MHC class I deficiency

Internal/Organ Research
Liver Defects

Metabolism Research
      iron metabolism defects

Research Tools
Immunology, Inflammation and Autoimmunity Research
      MHC class I deficiency

Pde6brd1 related

Sensorineural Research
Retinal Degeneration

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol B2mtm1Unc
Allele Name targeted mutation 1, University of North Carolina
Allele Type Targeted (Null/Knockout)
Common Name(s) I0; MHC-I-; b2mnull; beta2-m-KO; beta2M-; beta2MKO; beta2m0; beta2mnull; beta2mo; beta2mtm1Unc;
Mutation Made ByDr. Oliver Smithies,   University of North Carolina
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14TG2a
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name B2m, beta-2 microglobulin
Chromosome 2
Gene Common Name(s) Ly-m11; beta 2 microglobulin; beta2-m; lymphocyte antigen m11;
General Note Phenotypic Similarity to Human Syndrome: Inflammatory Bowel Disease (J:51450)
Molecular Note Insertion of a neomycin-resistance gene into the second exon. [MGI Ref ID J:65612]
Allele Symbol Pde6brd1
Allele Name retinal degeneration 1
Allele Type Spontaneous
Common Name(s) Pdebrd1; rd; rd-1; rd1; rodless retina;
Strain of Originvarious
Gene Symbol and Name Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Chromosome 5
Gene Common Name(s) CSNB3; CSNBAD2; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10;
General Note The following inbred strains are known to be homozygous for Pde6b: C3H sublines, CBA/J, FVB/NJ, PL/J, SB, SJL/J, and SWR/J.
Molecular Note Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested. [MGI Ref ID J:11513] [MGI Ref ID J:4366] [MGI Ref ID J:51361]


Genotyping Information

Genotyping Protocols

B2mtm1Unc, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Koller BH; Marrack P; Kappler JW; Smithies O. 1990. Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. Science 248(4960):1227-30. [PubMed: 2112266]  [MGI Ref ID J:64451]

Additional References

Jude BA; Pobezinskaya Y; Bishop J; Parke S; Medzhitov RM; Chervonsky AV; Golovkina TV. 2003. Subversion of the innate immune system by a retrovirus. Nat Immunol 4(6):573-8. [PubMed: 12730691]  [MGI Ref ID J:83088]

B2mtm1Unc related

Adoro S; Erman B; Sarafova SD; Van Laethem F; Park JH; Feigenbaum L; Singer A. 2008. Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic. J Immunol 181(10):6975-83. [PubMed: 18981117]  [MGI Ref ID J:140942]

Adoro S; McCaughtry T; Erman B; Alag A; Van Laethem F; Park JH; Tai X; Kimura M; Wang L; Grinberg A; Kubo M; Bosselut R; Love P; Singer A. 2011. Coreceptor gene imprinting governs thymocyte lineage fate. EMBO J 31(2):366-77. [PubMed: 22036949]  [MGI Ref ID J:180236]

Agerstam H; Jaras M; Andersson A; Johnels P; Hansen N; Lassen C; Rissler M; Gisselsson D; Olofsson T; Richter J; Fan X; Ehinger M; Fioretos T. 2010. Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice. Blood 116(12):2103-11. [PubMed: 20554971]  [MGI Ref ID J:164507]

Aguado E; Richelme S; Nunez-Cruz S; Miazek A; Mura AM; Richelme M; Guo XJ; Sainty D; He HT; Malissen B; Malissen M. 2002. Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science 296(5575):2036-40. [PubMed: 12065839]  [MGI Ref ID J:77098]

Albu DI; Vanvalkenburgh J; Morin N; Califano D; Jenkins NA; Copeland NG; Liu P; Avram D. 2011. Transcription factor Bcl11b controls selection of invariant natural killer T-cells by regulating glycolipid presentation in double-positive thymocytes. Proc Natl Acad Sci U S A 108(15):6211-6. [PubMed: 21444811]  [MGI Ref ID J:171277]

Aldrich CJ; Ljunggren HG; Van Kaer L; Ashton-Rickardt PG; Tonegawa S; Forman J. 1994. Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice. Proc Natl Acad Sci U S A 91(14):6525-8. [PubMed: 8022816]  [MGI Ref ID J:19192]

Alli R; Nguyen P; Boyd K; Sundberg JP; Geiger TL. 2012. A mouse model of clonal CD8+ T lymphocyte-mediated alopecia areata progressing to alopecia universalis. J Immunol 188(1):477-86. [PubMed: 22116824]  [MGI Ref ID J:180590]

Alsharifi M; Lobigs M; Simon MM; Kersten A; Muller K; Koskinen A; Lee E; Mullbacher A. 2006. NK cell-mediated immunopathology during an acute viral infection of the CNS. Eur J Immunol 36(4):887-96. [PubMed: 16541469]  [MGI Ref ID J:114787]

Antal Z; Baker JC; Smith C; Jarchum I; Babad J; Mukherjee G; Yang Y; Sidney J; Sette A; Santamaria P; DiLorenzo TP. 2012. Beyond HLA-A*0201: new HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8+ T cell epitopes. J Immunol 188(11):5766-75. [PubMed: 22539795]  [MGI Ref ID J:188404]

Apasov S; Sitkovsky M. 1993. Highly lytic CD8+, alpha beta T-cell receptor cytotoxic T cells with major histocompatibility complex (MHC) class I antigen-directed cytotoxicity in beta 2-microglobulin, MHC class I-deficient mice. Proc Natl Acad Sci U S A 90(7):2837-41. [PubMed: 8464897]  [MGI Ref ID J:4360]

Arnett HA; Wang Y; Matsushima GK; Suzuki K; Ting JP. 2003. Functional genomic analysis of remyelination reveals importance of inflammation in oligodendrocyte regeneration. J Neurosci 23(30):9824-32. [PubMed: 14586011]  [MGI Ref ID J:88200]

Ashour HM; Niederkorn JY. 2006. Peripheral tolerance via the anterior chamber of the eye: role of B cells in MHC class I and II antigen presentation. J Immunol 176(10):5950-7. [PubMed: 16670303]  [MGI Ref ID J:131707]

Assarsson E; Kambayashi T; Sandberg JK; Hong S; Taniguchi M; Van Kaer L; Ljunggren HG; Chambers BJ. 2000. CD8+ T cells rapidly acquire NK1.1 and NK cell-associated molecules upon stimulation in vitro and in vivo. J Immunol 165(7):3673-9. [PubMed: 11034371]  [MGI Ref ID J:118029]

Azuara V; Lembezat MP; Pereira P. 1998. The homogeneity of the TCRdelta repertoire expressed by the Thy-1dull gammadelta T cell population is due to cellular selection. Eur J Immunol 28(11):3456-67. [PubMed: 9842888]  [MGI Ref ID J:51177]

Babu S; Porte P; Klei TR; Shultz LD; Rajan TV. 1998. Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice. J Immunol 161(3):1428-32. [PubMed: 9686607]  [MGI Ref ID J:49819]

Baccala R; Witherden D; Gonzalez-Quintial R; Dummer W; Surh CD; Havran WL; Theofilopoulos AN. 2005. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors. J Immunol 174(8):4606-12. [PubMed: 15814683]  [MGI Ref ID J:98166]

Bain G; Quong MW; Soloff RS; Hedrick SM; Murre C. 1999. Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47. J Exp Med 190(11):1605-16. [PubMed: 10587351]  [MGI Ref ID J:58800]

Baldwin SL; Ching LK; Pine SO; Moutaftsi M; Lucas E; Vallur A; Orr MT; Bertholet S; Reed SG; Coler RN. 2013. Protection against tuberculosis with homologous or heterologous protein/vector vaccine approaches is not dependent on CD8+ T cells. J Immunol 191(5):2514-25. [PubMed: 23904160]  [MGI Ref ID J:205818]

Bannai M; Kawamura T; Naito T; Kameyama H; Abe T; Kawamura H; Tsukada C; Watanabe H; Hatakeyama K; Hamada H; Nishiyama Y; Ishikawa H; Takeda K; Okumura K; Taniguchi M; Abo T. 2001. Abundance of unconventional CD8(+) natural killer T cells in the large intestine. Eur J Immunol 31(11):3361-9. [PubMed: 11745354]  [MGI Ref ID J:72615]

Bard J; Yamazaki K; Curran M; Boyse EA; Beauchamp GK. 2000. Effect of B2m gene disruption on MHC-determined odortypes. Immunogenetics 51(7):514-8. [PubMed: 10912502]  [MGI Ref ID J:63063]

Basha G; Omilusik K; Chavez-Steenbock A; Reinicke AT; Lack N; Choi KB; Jefferies WA. 2012. A CD74-dependent MHC class I endolysosomal cross-presentation pathway. Nat Immunol 13(3):237-245. [PubMed: 22306692]  [MGI Ref ID J:181327]

Beauvillain C; Delneste Y; Scotet M; Peres A; Gascan H; Guermonprez P; Barnaba V; Jeannin P. 2007. Neutrophils efficiently cross-prime naive T cells in vivo. Blood 110(8):2965-73. [PubMed: 17562875]  [MGI Ref ID J:148908]

Behrens EM; Canna SW; Slade K; Rao S; Kreiger PA; Paessler M; Kambayashi T; Koretzky GA. 2011. Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice. J Clin Invest 121(6):2264-77. [PubMed: 21576823]  [MGI Ref ID J:173903]

Beilke JN; Kuhl NR; Van Kaer L; Gill RG. 2005. NK cells promote islet allograft tolerance via a perforin-dependent mechanism. Nat Med 11(10):1059-65. [PubMed: 16155578]  [MGI Ref ID J:101693]

Belanger S; Tu MM; Rahim MM; Mahmoud AB; Patel R; Tai LH; Troke AD; Wilhelm BT; Landry JR; Zhu Q; Tung KS; Raulet DH; Makrigiannis AP. 2012. Impaired natural killer cell self-education and "missing-self" responses in Ly49-deficient mice. Blood 120(3):592-602. [PubMed: 22661698]  [MGI Ref ID J:189106]

Ben Baruch-Morgenstern N; Shik D; Moshkovits I; Itan M; Karo-Atar D; Bouffi C; Fulkerson PC; Rashkovan D; Jung S; Rothenberg ME; Munitz A. 2014. Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil development. Nat Immunol 15(1):36-44. [PubMed: 24212998]  [MGI Ref ID J:208993]

Bender BS; Croghan T; Zhang L; Small PA Jr. 1992. Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge. J Exp Med 175(4):1143-5. [PubMed: 1552285]  [MGI Ref ID J:110598]

Berg RE; Princiotta MF; Irion S; Moticka JA; Dahl KR; Staerz UD. 1999. Positive selection of an H2-M3 restricted T cell receptor. Immunity 11(1):33-43. [PubMed: 10435577]  [MGI Ref ID J:110475]

Bessoles S; Angelov GS; Back J; Leclercq G; Vivier E; Held W. 2013. Education of murine NK cells requires both cis and trans recognition of MHC class I molecules. J Immunol 191(10):5044-51. [PubMed: 24098052]  [MGI Ref ID J:206339]

Bienvenu B; Martin B; Auffray C; Cordier C; Becourt C; Lucas B. 2005. Peripheral CD8+CD25+ T lymphocytes from MHC class II-deficient mice exhibit regulatory activity. J Immunol 175(1):246-53. [PubMed: 15972655]  [MGI Ref ID J:100582]

Birnberg T; Bar-On L; Sapoznikov A; Caton ML; Cervantes-Barragan L; Makia D; Krauthgamer R; Brenner O; Ludewig B; Brockschnieder D; Riethmacher D; Reizis B; Jung S. 2008. Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome. Immunity 29(6):986-97. [PubMed: 19062318]  [MGI Ref ID J:142682]

Bitsaktsis C; Winslow G. 2006. Fatal recall responses mediated by CD8 T cells during intracellular bacterial challenge infection. J Immunol 177(7):4644-51. [PubMed: 16982903]  [MGI Ref ID J:139316]

Blancou P; Mallone R; Martinuzzi E; Severe S; Pogu S; Novelli G; Bruno G; Charbonnel B; Dolz M; Chaillous L; van Endert P; Bach JM. 2007. Immunization of HLA class I transgenic mice identifies autoantigenic epitopes eliciting dominant responses in type 1 diabetes patients. J Immunol 178(11):7458-66. [PubMed: 17513797]  [MGI Ref ID J:147823]

Bonig H; Priestley GV; Oehler V; Papayannopoulou T. 2007. Hematopoietic progenitor cells (HPC) from mobilized peripheral blood display enhanced migration and marrow homing compared to steady-state bone marrow HPC. Exp Hematol 35(2):326-34. [PubMed: 17258081]  [MGI Ref ID J:123189]

Boucherma R; Kridane-Miledi H; Bouziat R; Rasmussen M; Gatard T; Langa-Vives F; Lemercier B; Lim A; Berard M; Benmohamed L; Buus S; Rooke R; Lemonnier FA. 2013. HLA-A*01:03, HLA-A*24:02, HLA-B*08:01, HLA-B*27:05, HLA-B*35:01, HLA-B*44:02, and HLA-C*07:01 monochain transgenic/H-2 class I null mice: novel versatile preclinical models of human T cell responses. J Immunol 191(2):583-93. [PubMed: 23776170]  [MGI Ref ID J:205453]

Bowen S; Sun P; Livak F; Sharrow S; Hodes RJ. 2014. A novel T cell subset with trans-rearranged Vgamma-Cbeta TCRs shows Vbeta expression is dispensable for lineage choice and MHC restriction. J Immunol 192(1):169-77. [PubMed: 24307734]  [MGI Ref ID J:207166]

Brawand P; Lemonnier FA; MacDonald HR; Cerottini JC; Held W. 2000. Transgenic expression of Ly49A on T cells impairs a specific antitumor response. J Immunol 165(4):1871-6. [PubMed: 10925266]  [MGI Ref ID J:108611]

Brossay L; Jullien D; Cardell S; Sydora BC; Burdin N; Modlin RL ; Kronenberg M. 1997. Mouse CD1 is mainly expressed on hemopoietic-derived cells. J Immunol 159(3):1216-24. [PubMed: 9233616]  [MGI Ref ID J:41641]

Buhlmann JE; Foy TM; Aruffo A; Crassi KM; Ledbetter JA; Green WR; Xu JC; Shultz LD; Roopesian D; Flavell RA; et al.. 1995. In the absence of a CD40 signal, B cells are tolerogenic. Immunity 2(6):645-53. [PubMed: 7540943]  [MGI Ref ID J:189416]

Buning J; Schmitz M; Repenning B; Ludwig D; Schmidt MA; Strobel S; Zimmer KP. 2005. Interferon-gamma mediates antigen trafficking to MHC class II-positive late endosomes of enterocytes. Eur J Immunol 35(3):831-42. [PubMed: 15688349]  [MGI Ref ID J:96737]

Buxbaum LU; Scott P. 2005. Interleukin 10- and Fcgamma receptor-deficient mice resolve Leishmania mexicana lesions. Infect Immun 73(4):2101-8. [PubMed: 15784551]  [MGI Ref ID J:97206]

Cady CT; Lahn M; Vollmer M; Tsuji M; Seo SJ; Reardon CL; O'Brien RL; Born WK. 2000. Response of murine gamma delta T cells to the synthetic polypeptide poly-Glu50Tyr50. J Immunol 165(4):1790-8. [PubMed: 10925256]  [MGI Ref ID J:120419]

Cain JA; Smith JA; Ondr JK; Wang B; Katz JD. 2006. NKT cells and IFN-gamma establish the regulatory environment for the control of diabetogenic T cells in the nonobese diabetic mouse. J Immunol 176(3):1645-54. [PubMed: 16424194]  [MGI Ref ID J:126603]

Canonne-Hergaux F; Levy JE; Fleming MD; Montross LK; Andrews NC; Gros P. 2001. Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. Blood 97(4):1138-40. [PubMed: 11159549]  [MGI Ref ID J:67402]

Capone M; Lees RK; Finke D; Ernst B; Meerwijk JP; MacDonald HR. 2003. Selective absence of CD8+ TCRalpha beta+ intestinal epithelial cells in transgenic mice expressing beta2-microglobulin-associated ligands exclusively on thymic cortical epithelium. Eur J Immunol 33(6):1471-7. [PubMed: 12778464]  [MGI Ref ID J:83888]

Carrier J; Medline A; Sohn KJ; Choi M; Martin R; Hwang SW; Kim YI. 2003. Effects of dietary folate on ulcerative colitis-associated colorectal carcinogenesis in the interleukin 2- and beta(2)-microglobulin-deficient mice. Cancer Epidemiol Biomarkers Prev 12(11 Pt 1):1262-7. [PubMed: 14652292]  [MGI Ref ID J:87528]

Case LK; Petell L; Yurkovetskiy L; Purdy A; Savage KJ; Golovkina TV. 2008. Replication of beta- and gammaretroviruses is restricted in I/LnJ mice via the same genetic mechanism. J Virol 82(3):1438-47. [PubMed: 18057254]  [MGI Ref ID J:163153]

Castellino F; Huang AY; Altan-Bonnet G; Stoll S; Scheinecker C; Germain RN. 2006. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature 440(7086):890-5. [PubMed: 16612374]  [MGI Ref ID J:107629]

Chaise C; Buchan SL; Rice J; Marquet J; Rouard H; Kuentz M; Vittes GE; Molinier-Frenkel V; Farcet JP; Stauss HJ; Delfau-Larue MH; Stevenson FK. 2008. DNA vaccination induces WT1-specific T-cell responses with potential clinical relevance. Blood 112(7):2956-64. [PubMed: 18502835]  [MGI Ref ID J:140153]

Chamero P; Marton TF; Logan DW; Flanagan K; Cruz JR; Saghatelian A; Cravatt BF; Stowers L. 2007. Identification of protein pheromones that promote aggressive behaviour. Nature 450(7171):899-902. [PubMed: 18064011]  [MGI Ref ID J:130465]

Champsaur M; Beilke JN; Ogasawara K; Koszinowski UH; Jonjic S; Lanier LL. 2010. Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1. J Immunol 185(1):157-65. [PubMed: 20530257]  [MGI Ref ID J:161608]

Chan OT; Paliwal V; McNiff JM; Park SH; Bendelac A; Shlomchik MJ. 2001. Deficiency in beta(2)-Microglobulin, But Not CD1, Accelerates Spontaneous Lupus Skin Disease While Inhibiting Nephritis in MRL-Fas(lpr) Mice: An Example of Disease Regulation at the Organ Level. J Immunol 167(5):2985-90. [PubMed: 11509649]  [MGI Ref ID J:71175]

Chan S; Correia-Neves M; Dierich A; Benoist C; Mathis D. 1998. Visualization of CD4/CD8 T cell commitment. J Exp Med 188(12):2321-33. [PubMed: 9858518]  [MGI Ref ID J:113263]

Chan SH; Cosgrove D; Waltzinger C; Benoist C; Mathis D. 1993. Another view of the selective model of thymocyte selection. Cell 73(2):225-36. [PubMed: 8097430]  [MGI Ref ID J:111130]

Chaudhury C; Kim J; Mehnaz S; Wani MA; Oberyszyn TM; Bronson CL; Mohanty S; Hayton WL; Robinson JM; Anderson CL. 2006. Accelerated transferrin degradation in HFE-deficient mice is associated with increased transferrin saturation. J Nutr 136(12):2993-8. [PubMed: 17116709]  [MGI Ref ID J:117735]

Chaudhury C; Mehnaz S; Robinson JM; Hayton WL; Pearl DK; Roopenian DC; Anderson CL. 2003. The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan. J Exp Med 197(3):315-22. [PubMed: 12566415]  [MGI Ref ID J:110885]

Chen L; Jay DC; Fairbanks JD; He X; Jensen PE. 2011. An MHC class Ib-restricted CD8+ T cell response to lymphocytic choriomeningitis virus. J Immunol 187(12):6463-72. [PubMed: 22084437]  [MGI Ref ID J:180389]

Chen M; Tabaczewski P; Truscott SM; Van Kaer L; Stroynowski I. 2005. Hepatocytes express abundant surface class I MHC and efficiently use transporter associated with antigen processing, tapasin, and low molecular weight polypeptide proteasome subunit components of antigen processing and presentation pathway. J Immunol 175(2):1047-55. [PubMed: 16002705]  [MGI Ref ID J:100733]

Chen X; Tang Y; Zhang Y; Zhuo M; Tang Z; Yu Y; Zang G. 2014. Tapasin modification on the intracellular epitope HBcAg18-27 enhances HBV-specific CTL immune response and inhibits hepatitis B virus replication in vivo. Lab Invest 94(5):478-90. [PubMed: 24614195]  [MGI Ref ID J:208402]

Chen YG; Chen J; Osborne MA; Chapman HD; Besra GS; Porcelli SA; Leiter EH; Wilson SB; Serreze DV. 2006. CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice. J Immunol 177(5):2939-47. [PubMed: 16920929]  [MGI Ref ID J:112615]

Chiang EY; Stroynowski I. 2004. A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor. J Immunol 173(7):4394-401. [PubMed: 15383569]  [MGI Ref ID J:93729]

Chiodoni C; Stoppacciaro A; Sangaletti S; Gri G; Cappetti B; Koezuka Y; Colombo MP. 2001. Different requirements for alpha-galactosylceramide and recombinant IL-12 antitumor activity in the treatment of C-26 colon carcinoma hepatic metastases. Eur J Immunol 31(10):3101-10. [PubMed: 11592087]  [MGI Ref ID J:115631]

Chiu NM; Wang B; Kerksiek KM; Kurlander R; Pamer EG; Wang CR. 1999. The selection of M3-restricted T cells is dependent on M3 expression and presentation of N-formylated peptides in the thymus. J Exp Med 190(12):1869-78. [PubMed: 10601361]  [MGI Ref ID J:131934]

Cho H; Choi HJ; Xu H; Felio K; Wang CR. 2011. Nonconventional CD8+ T cell responses to Listeria infection in mice lacking MHC class Ia and H2-M3. J Immunol 186(1):489-98. [PubMed: 21098224]  [MGI Ref ID J:168008]

Chong SZ; Tan KW; Wong FH; Chua YL; Tang Y; Ng LG; Angeli V; Kemeny DM. 2014. CD8 T Cells Regulate Allergic Contact Dermatitis by Modulating CCR2-Dependent TNF/iNOS-Expressing Ly6C(+)CD11b(+) Monocytic Cells. J Invest Dermatol 134(3):666-76. [PubMed: 24061165]  [MGI Ref ID J:206039]

Christianson GJ; Blankenburg RL; Duffy TM; Panka D; Roths JB; Marshak-Rothstein A; Roopenian DC. 1996. beta2-microglobulin dependence of the lupus-like autoimmune syndrome of MRL-lpr mice. J Immunol 156(12):4932-9. [PubMed: 8648144]  [MGI Ref ID J:33405]

Christianson SW; Greiner DL; Hesselton RA; Leif JH; Wagar EJ; Schweitzer IB; Rajan TV; Gott B; Roopenian DC; Shultz LD. 1997. Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice. J Immunol 158(8):3578-86. [PubMed: 9103418]  [MGI Ref ID J:102141]

Christianson SW; Greiner DL; Schweitzer IB; Gott B; Beamer GL; Schweitzer PA; Hesselton RM; Shultz LD. 1996. Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice. Cell Immunol 171(2):186-99. [PubMed: 8806787]  [MGI Ref ID J:34814]

Christopher K; Liang Y; Mueller TF; DeFina R; He H; Haley KJ; Exley MA; Finn PW; Perkins DL. 2004. Analysis of the major histocompatibility complex in graft rejection revisited by gene expression profiles. Transplantation 78(6):788-98. [PubMed: 15385796]  [MGI Ref ID J:98356]

Cogen AL; Moore TA. 2009. Beta2-microglobulin-dependent bacterial clearance and survival during murine Klebsiella pneumoniae bacteremia. Infect Immun 77(1):360-6. [PubMed: 18981251]  [MGI Ref ID J:143765]

Coles MC; Raulet DH. 1994. Class I dependence of the development of CD4+ CD8- NK1.1+ thymocytes. J Exp Med 180(1):395-9. [PubMed: 8006596]  [MGI Ref ID J:110734]

Coles MC; Raulet DH. 2000. NK1.1+ T cells in the liver arise in the thymus and are selected by interactions with class I molecules on CD4+CD8+ cells. J Immunol 164(5):2412-8. [PubMed: 10679077]  [MGI Ref ID J:112051]

Constante M; Wang D; Raymond VA; Bilodeau M; Santos MM. 2007. Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha. Am J Pathol 170(2):497-504. [PubMed: 17255318]  [MGI Ref ID J:117889]

Cook JR; Solheim JC; Connolly JM; Hansen TH. 1995. Induction of peptide-specific CD8+ CTL clones in beta 2-microglobulin-deficient mice. J Immunol 154(1):47-57. [PubMed: 7995959]  [MGI Ref ID J:22257]

Coppieters KT; Amirian N; von Herrath MG. 2011. Incidental CD8 T cell reactivity against caspase-cleaved apoptotic self-antigens from ubiquitously expressed proteins in islets from prediabetic human leucocyte antigen-A2 transgenic non-obese diabetic mice. Clin Exp Immunol 165(2):155-62. [PubMed: 21605113]  [MGI Ref ID J:175948]

Corr M; Crain B. 2002. The role of FcgammaR signaling in the K/B x N serum transfer model of arthritis. J Immunol 169(11):6604-9. [PubMed: 12444173]  [MGI Ref ID J:124384]

Coudert JD; Foucras G; Demur C; Coureau C; Mazerolles C; Delsol G; Druet P; Guery JC. 2000. Lethal host-versus-graft disease and hypereosinophilia in the absence of MHC I-T-cell interactions. J Clin Invest 105(8):1125-32. [PubMed: 10772657]  [MGI Ref ID J:120539]

Creusot RJ; Yaghoubi SS; Kodama K; Dang DN; Dang VH; Breckpot K; Thielemans K; Gambhir SS; Fathman CG. 2008. Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice. Clin Immunol 127(2):176-87. [PubMed: 18337172]  [MGI Ref ID J:133579]

Crow AR; Suppa SJ; Chen X; Mott PJ; Lazarus AH. 2011. The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody-mediated amelioration of murine immune thrombocytopenia. Blood 118(24):6403-6. [PubMed: 22001393]  [MGI Ref ID J:179078]

Crozat K; Hoebe K; Ugolini S; Hong NA; Janssen E; Rutschmann S; Mudd S; Sovath S; Vivier E; Beutler B. 2007. Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis. J Exp Med 204(4):853-63. [PubMed: 17420270]  [MGI Ref ID J:119974]

D'Orazio TJ; Mayhew E; Niederkorn JY. 2001. Ocular immune privilege promoted by the presentation of peptide on tolerogenic B cells in the spleen. II. Evidence for presentation by Qa-1 J Immunol 166(1):26-32. [PubMed: 11123273]  [MGI Ref ID J:66404]

D'Souza CD; Cooper AM; Frank AA; Ehlers S; Turner J; Bendelac A; Orme IM. 2000. A novel nonclassic beta2-microglobulin-restricted mechanism influencing early lymphocyte accumulation and subsequent resistance to tuberculosis in the lung. Am J Respir Cell Mol Biol 23(2):188-93. [PubMed: 10919985]  [MGI Ref ID J:114179]

Dalloul AH; Ngo K; Fung-Leung WP. 1996. CD4-negative cytotoxic T cells with a T cell receptor alpha/beta intermediate expression in CD8-deficient mice. Eur J Immunol 26(1):213-8. [PubMed: 8566069]  [MGI Ref ID J:112982]

Dang Y; Heyborne KD. 2001. Cutting edge: regulation of uterine NKT cells by a fetal class I molecule other than CD1. J Immunol 166(6):3641-4. [PubMed: 11238600]  [MGI Ref ID J:126656]

Daniels MA; Teixeiro E; Gill J; Hausmann B; Roubaty D; Holmberg K; Werlen G; Hollander GA; Gascoigne NR; Palmer E. 2006. Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature 444(7120):724-9. [PubMed: 17086201]  [MGI Ref ID J:117478]

Dao T; Exley M; Mehal WZ; Tahir SM; Snapper S; Taniguchi M; Balk SP; Crispe IN. 2001. Involvement of CD1 in peripheral deletion of T lymphocytes is independent of NK T cells. J Immunol 166(5):3090-7. [PubMed: 11207260]  [MGI Ref ID J:76978]

Das G; Das J; Eynott P; Zhang Y; Bothwell AL; Van Kaer L; Shi Y. 2006. Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases. J Exp Med 203(12):2603-11. [PubMed: 17088432]  [MGI Ref ID J:124622]

Das G; Janeway CA Jr. 1999. Development of CD8alpha/alpha and CD8alpha/beta T cells in major histocompatibility complex class I-deficient mice. J Exp Med 190(6):881-4. [PubMed: 10499926]  [MGI Ref ID J:57703]

Das G; Sheridan S; Janeway CA Jr. 2001. The source of early IFN-gamma that plays a role in Th1 priming. J Immunol 167(4):2004-10. [PubMed: 11489982]  [MGI Ref ID J:110883]

Dautigny N; Le Campion A; Lucas B. 1999. Timing and casting for actors of thymic negative selection. J Immunol 162(3):1294-302. [PubMed: 9973382]  [MGI Ref ID J:124433]

Deane R; Sagare A; Hamm K; Parisi M; LaRue B; Guo H; Wu Z; Holtzman DM; Zlokovic BV. 2005. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci 25(50):11495-503. [PubMed: 16354907]  [MGI Ref ID J:103998]

Diaz-de-Durana Y; Mantchev GT; Bram RJ; Franco A. 2006. TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo. Blood 107(2):594-601. [PubMed: 16195331]  [MGI Ref ID J:126637]

Do JS; Min B. 2009. Differential requirements of MHC and of DCs for endogenous proliferation of different T-cell subsets in vivo. Proc Natl Acad Sci U S A 106(48):20394-8. [PubMed: 19920180]  [MGI Ref ID J:155564]

Dong Z; Davidson D; Perez-Quintero LA; Kurosaki T; Swat W; Veillette A. 2012. The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells. Immunity 36(6):974-85. [PubMed: 22683124]  [MGI Ref ID J:187430]

Dragovic SM; Hill T; Christianson GJ; Kim S; Elliott T; Scott D; Roopenian DC; Van Kaer L; Joyce S. 2011. Proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ Th cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigens. J Immunol 186(12):6683-92. [PubMed: 21572029]  [MGI Ref ID J:175483]

Drake DR 3rd; Lukacher AE. 1998. Beta 2-microglobulin knockout mice are highly susceptible to polyoma virus tumorigenesis. Virology 252(1):275-84. [PubMed: 9875336]  [MGI Ref ID J:52185]

Dubois A; Deruytter N; Adams B; Kanda A; Delbauve S; Fleury S; Torres D; Francois A; Petein M; Goldman M; Dombrowicz D; Flamand V. 2010. Regulation of Th2 responses and allergic inflammation through bystander activation of CD8+ T lymphocytes in early life. J Immunol 185(2):884-91. [PubMed: 20562264]  [MGI Ref ID J:161925]

Elewaut D; Brossay L; Santee SM; Naidenko OV; Burdin N; De Winter H; Matsuda J; Ware CF; Cheroutre H; Kronenberg M. 2000. Membrane lymphotoxin is required for the development of different subpopulations of NK T cells. J Immunol 165(2):671-9. [PubMed: 10878339]  [MGI Ref ID J:106601]

Elewaut D; Shaikh RB; Hammond KJ; De Winter H; Leishman AJ; Sidobre S; Turovskaya O; Prigozy TI; Ma L; Banks TA; Lo D; Ware CF; Cheroutre H; Kronenberg M. 2003. NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells. J Exp Med 197(12):1623-33. [PubMed: 12810685]  [MGI Ref ID J:120659]

Emoto M; Emoto Y; Brinkmann V; Miyamoto M; Yoshizawa I; Staber M; van Rooijen N; Hamann A; Kaufmann SH. 2003. Increased resistance of LFA-1-deficient mice to lipopolysaccharide-induced shock/liver injury in the presence of TNF-alpha and IL-12 is mediated by IL-10: a novel role for LFA-1 in the regulation of the proinflammatory and anti-inflammatory cytokine balance. J Immunol 171(2):584-93. [PubMed: 12847222]  [MGI Ref ID J:123460]

Enoh VT; Lin CY; Varma TK; Sherwood ER. 2006. Differential effect of imipenem treatment on injury caused by cecal ligation and puncture in wild-type and NK cell-deficient beta(2)-microgloblin knockout mice. Am J Physiol Gastrointest Liver Physiol 290(2):G277-84. [PubMed: 16166341]  [MGI Ref ID J:106051]

Eppert BL; Wortham BW; Flury JL; Borchers MT. 2013. Functional characterization of T cell populations in a mouse model of chronic obstructive pulmonary disease. J Immunol 190(3):1331-40. [PubMed: 23264660]  [MGI Ref ID J:192605]

Erman B; Guinter TI; Singer A. 2004. Defined alphabeta T cell receptors with distinct ligand specificities do not require those ligands to signal double negative thymocyte differentiation. J Exp Med 199(12):1719-24. [PubMed: 15210747]  [MGI Ref ID J:120401]

Escande-Beillard N; Washburn L; Zekzer D; Wu ZP; Eitan S; Ivkovic S; Lu Y; Dang H; Middleton B; Bilousova TV; Yoshimura Y; Evans CJ; Joyce S; Tian J; Kaufman DL. 2010. Neurons preferentially respond to self-MHC class I allele products regardless of peptide presented. J Immunol 184(2):816-23. [PubMed: 20018625]  [MGI Ref ID J:159396]

Fahlen L; Lendahl U; Sentman CL. 2001. MHC class I-Ly49 interactions shape the Ly49 repertoire on murine NK cells. J Immunol 166(11):6585-92. [PubMed: 11359811]  [MGI Ref ID J:133137]

Farr AR; Wu W; Choi B; Cavalcoli JD; Laouar Y. 2014. CD1d-unrestricted NKT cells are endowed with a hybrid function far superior than that of iNKT cells. Proc Natl Acad Sci U S A 111(35):12841-6. [PubMed: 25143585]  [MGI Ref ID J:216401]

Felio K; Nguyen H; Dascher CC; Choi HJ; Li S; Zimmer MI; Colmone A; Moody DB; Brenner MB; Wang CR. 2009. CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice. J Exp Med 206(11):2497-509. [PubMed: 19808251]  [MGI Ref ID J:154072]

Felix NJ; Brickey WJ; Griffiths R; Zhang J; Van Kaer L; Coffman T; Ting JP. 2000. H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection. J Exp Med 192(1):31-40. [PubMed: 10880524]  [MGI Ref ID J:63144]

Feng N; Kim B; Fenaux M; Nguyen H; Vo P; Omary MB; Greenberg HB. 2008. Role of interferon in homologous and heterologous rotavirus infection in the intestines and extraintestinal organs of suckling mice. J Virol 82(15):7578-90. [PubMed: 18495762]  [MGI Ref ID J:153415]

Feuillet V; Lucas B; Di Santo JP; Bismuth G; Trautmann A. 2005. Multiple survival signals are delivered by dendritic cells to naive CD4+ T cells. Eur J Immunol 35(9):2563-72. [PubMed: 16078277]  [MGI Ref ID J:113487]

Fiette L; Aubert C; Brahic M; Rossi CP. 1993. Theiler's virus infection of beta 2-microglobulin-deficient mice. J Virol 67(1):589-92. [PubMed: 8416386]  [MGI Ref ID J:3649]

Firat H; Tourdot S; Ureta-Vidal A; Scardino A; Suhrbier A; Buseyne F; Riviere Y; Danos O; Michel ML; Kosmatopoulos K; Lemonnier FA. 2001. Design of a polyepitope construct for the induction of HLA-A0201-restricted HIV 1-specific CTL responses using HLA-A*0201 transgenic, H-2 class I KO mice. Eur J Immunol 31(10):3064-74. [PubMed: 11592083]  [MGI Ref ID J:115621]

Flatz L; Rieger T; Merkler D; Bergthaler A; Regen T; Schedensack M; Bestmann L; Verschoor A; Kreutzfeldt M; Bruck W; Hanisch UK; Gunther S; Pinschewer DD. 2010. T cell-dependence of Lassa fever pathogenesis. PLoS Pathog 6(3):e1000836. [PubMed: 20360949]  [MGI Ref ID J:162954]

Flynn JL; Goldstein MM; Triebold KJ; Koller B; Bloom BR. 1992. Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A 89(24):12013-7. [PubMed: 1465432]  [MGI Ref ID J:111189]

Fortner KA; Lees RK; Macdonald HR; Budd RC. 2011. Fas (CD95/APO-1) limits the expansion of T lymphocytes in an environment of limited T-cell antigen receptor/MHC contacts. Int Immunol 23(2):75-88. [PubMed: 21266499]  [MGI Ref ID J:168554]

Foucras G; Coudert JD; Coureau C; Guery JC. 2000. Dendritic cells prime in vivo alloreactive CD4 T lymphocytes toward type 2 cytokine- and TGF-beta-producing cells in the absence of CD8 T cell activation. J Immunol 165(9):4994-5003. [PubMed: 11046027]  [MGI Ref ID J:118923]

Freland S; Chambers BJ; Andersson M; Van Kaer L; Ljunggren HG. 1998. Rejection of allogeneic and syngeneic but not MHC class I-deficient tumor grafts by MHC class I-deficient mice. J Immunol 160(2):572-9. [PubMed: 9551890]  [MGI Ref ID J:45189]

Freland S; Ljunggren H. 2000. beta2-Microglobulin/CD8 -/- mice reveal significant role for CD8+ T cells in graft rejection responses in beta2-microglobulin -/- mice Scand J Immunol 51(3):219-23. [PubMed: 10736089]  [MGI Ref ID J:61231]

French JD; Roark CL; Born WK; O'brien RL. 2005. {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells. Proc Natl Acad Sci U S A 102(41):14741-6. [PubMed: 16203967]  [MGI Ref ID J:102497]

Fritz RB; Zhao ML. 2001. Regulation of experimental autoimmune encephalomyelitis in the C57BL/6J mouse by NK1.1+, DX5+, alpha beta+ T cells. J Immunol 166(6):4209-15. [PubMed: 11238673]  [MGI Ref ID J:126134]

Fukui Y; Hashimoto O; Inayoshi A; Gyotoku T; Sano T; Koga T; Gushima T; Sasazuki T. 1998. Highly restricted T cell repertoire shaped by a single major histocompatibility complex-peptide ligand in the presence of a single rearranged T cell receptor beta chain. J Exp Med 188(5):897-907. [PubMed: 9730891]  [MGI Ref ID J:115130]

Fukui Y; Oono T; Cabaniols JP; Nakao K; Hirokawa K; Inayoshi A; Sanui T; Kanellopoulos J; Iwata E; Noda M; Katsuki M; Kourilsky P; Sasazuki T. 2000. Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact. Proc Natl Acad Sci U S A 97(25):13760-5. [PubMed: 11087837]  [MGI Ref ID J:125474]

Gadue P; Morton N; Stein PL. 1999. The Src family tyrosine kinase Fyn regulates natural killer T cell development. J Exp Med 190(8):1189-96. [PubMed: 10523617]  [MGI Ref ID J:110943]

Gapin L; Cheroutre H; Kronenberg M. 1999. Cutting edge: TCR alpha beta+ CD8 alpha alpha+ T cells are found in intestinal intraepithelial lymphocytes of mice that lack classical MHC class I molecules. J Immunol 163(8):4100-4. [PubMed: 10510343]  [MGI Ref ID J:111019]

Gasteiger G; Hemmers S; Firth MA; Le Floc'h A; Huse M; Sun JC; Rudensky AY. 2013. IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells. J Exp Med 210(6):1167-78. [PubMed: 23650441]  [MGI Ref ID J:200961]

Ghendler Y; Teng MK; Liu JH; Witte T; Liu J; Kim KS; Kern P; Chang HC; Wang JH; Reinherz EL. 1998. Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands. Proc Natl Acad Sci U S A 95(17):10061-6. [PubMed: 9707600]  [MGI Ref ID J:119802]

Ghetie V; Hubbard JG; Kim JK; Tsen MF; Lee Y; Ward ES. 1996. Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice. Eur J Immunol 26(3):690-6. [PubMed: 8605939]  [MGI Ref ID J:31992]

Glas R; Ohlen C; Hoglund P; Karre K. 1994. The CD8+ T cell repertoire in beta 2-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I. J Exp Med 179(2):661-72. [PubMed: 8294874]  [MGI Ref ID J:16604]

Glimm H; Eisterer W; Lee K; Cashman J; Holyoake TL; Nicolini F; Shultz LD; von Kalle C; Eaves CJ. 2001. Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice. J Clin Invest 107(2):199-206. [PubMed: 11160136]  [MGI Ref ID J:66974]

Glynn MW; Elmer BM; Garay PA; Liu XB; Needleman LA; El-Sabeawy F; McAllister AK. 2011. MHCI negatively regulates synapse density during the establishment of cortical connections. Nat Neurosci 14(4):442-51. [PubMed: 21358642]  [MGI Ref ID J:172306]

Gombold JL; Sutherland RM; Lavi E; Paterson Y; Weiss SR. 1995. Mouse hepatitis virus A59-induced demyelination can occur in the absence of CD8+ T cells. Microb Pathog 18(3):211-21. [PubMed: 7565015]  [MGI Ref ID J:127517]

Gonzalez A; Andre-Schmutz I; Carnaud C; Mathis D; Benoist C. 2001. Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes. Nat Immunol 2(12):1117-25. [PubMed: 11713466]  [MGI Ref ID J:109860]

Graf D; Nethisinghe S; Palmer DB; Fisher AG; Merkenschlager M. 2002. The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development. J Exp Med 196(2):163-71. [PubMed: 12119341]  [MGI Ref ID J:120461]

Grange RW; Gainer TG; Marschner KM; Talmadge RJ; Stull JT. 2002. Fast-twitch skeletal muscles of dystrophic mouse pups are resistant to injury from acute mechanical stress. Am J Physiol Cell Physiol 283(4):C1090-101. [PubMed: 12225973]  [MGI Ref ID J:107767]

Graser RT; DiLorenzo TP; Wang F; Christianson GJ; Chapman HD; Roopenian DC; Nathenson SG; Serreze DV. 2000. Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions. J Immunol 164(7):3913-8. [PubMed: 10725754]  [MGI Ref ID J:93553]

Gritzapis AD; Mahaira LG; Perez SA; Cacoullos NT; Papamichail M; Baxevanis CN. 2006. Vaccination with human HER-2/neu (435-443) CTL peptide induces effective antitumor immunity against HER-2/neu-expressing tumor cells in vivo. Cancer Res 66(10):5452-60. [PubMed: 16707474]  [MGI Ref ID J:109050]

Gruber A; Cannarile MA; Cheminay C; Ried C; Marconi P; Hacker G; Brocker T. 2010. Parenchymal cells critically curtail cytotoxic T-cell responses by inducing Bim-mediated apoptosis. Eur J Immunol 40(4):966-75. [PubMed: 20127674]  [MGI Ref ID J:159191]

Grubin CE; Kovats S; deRoos P; Rudensky AY. 1997. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity 7(2):197-208. [PubMed: 9285405]  [MGI Ref ID J:84193]

Guery JC; Galbiati F; Smiroldo S; Adorini L. 1996. Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice. J Exp Med 183(2):485-97. [PubMed: 8627161]  [MGI Ref ID J:31311]

Guimond MJ; Luross JA; Wang B; Terhorst C; Danial S; Croy BA. 1997. Absence of natural killer cells during murine pregnancy is associated with reproductive compromise in TgE26 mice. Biol Reprod 56(1):169-79. [PubMed: 9002646]  [MGI Ref ID J:134589]

Guleria I; Gubbels Bupp M; Dada S; Fife B; Tang Q; Ansari MJ; Trikudanathan S; Vadivel N; Fiorina P; Yagita H; Azuma M; Atkinson M; Bluestone JA; Sayegh MH. 2007. Mechanisms of PDL1-mediated regulation of autoimmune diabetes. Clin Immunol 125(1):16-25. [PubMed: 17627890]  [MGI Ref ID J:125272]

Hamilton-Williams EE; Serreze DV; Charlton B; Johnson EA; Marron MP; Mullbacher A; Slattery RM. 2001. Transgenic rescue implicates beta 2-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice. Proc Natl Acad Sci U S A 98(20):11533-8. [PubMed: 11572996]  [MGI Ref ID J:71837]

Hancock WW; Tsai TL; Madaio MP; Gasser DL. 2003. Cutting Edge: Multiple autoimmune pathways in kd/kd mice. J Immunol 171(6):2778-81. [PubMed: 12960297]  [MGI Ref ID J:85380]

Hausmann J; Pagenstecher A; Baur K; Richter K; Rziha HJ; Staeheli P. 2005. CD8 T cells require gamma interferon to clear borna disease virus from the brain and prevent immune system-mediated neuronal damage. J Virol 79(21):13509-18. [PubMed: 16227271]  [MGI Ref ID J:102183]

Hayakawa Y; Watt SV; Takeda K; Smyth MJ. 2008. Distinct receptor repertoire formation in mouse NK cell subsets regulated by MHC class I expression. J Leukoc Biol 83(1):106-11. [PubMed: 17940219]  [MGI Ref ID J:130091]

Hayward SL; Bautista-Lopez N; Suzuki K; Atrazhev A; Dickie P; Elliott JF. 2006. CD4 T cells play major effector role and CD8 T cells initiating role in spontaneous autoimmune myocarditis of HLA-DQ8 transgenic IAb knockout nonobese diabetic mice. J Immunol 176(12):7715-25. [PubMed: 16751419]  [MGI Ref ID J:113267]

He X; Park K; Wang H; He X; Zhang Y; Hua X; Li Y; Kappes DJ. 2008. CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus. Immunity 28(3):346-58. [PubMed: 18342007]  [MGI Ref ID J:132996]

Hida S; Ogasawara K; Sato K; Abe M; Takayanagi H; Yokochi T; Sato T; Hirose S; Shirai T; Taki S; Taniguchi T. 2000. CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling Immunity 13(5):643-55. [PubMed: 11114377]  [MGI Ref ID J:66034]

Hida S; Tadachi M; Saito T; Taki S. 2005. Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance. Blood 106(6):2011-7. [PubMed: 15914553]  [MGI Ref ID J:118863]

Hikosaka Y; Nitta T; Ohigashi I; Yano K; Ishimaru N; Hayashi Y; Matsumoto M; Matsuo K; Penninger JM; Takayanagi H; Yokota Y; Yamada H; Yoshikai Y; Inoue J; Akiyama T; Takahama Y. 2008. The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity 29(3):438-50. [PubMed: 18799150]  [MGI Ref ID J:139648]

Hiramatsu H; Nishikomori R; Heike T; Ito M; Kobayashi K; Katamura K; Nakahata T. 2003. Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model. Blood 102(3):873-80. [PubMed: 12689924]  [MGI Ref ID J:163372]

Hirayama M; Genyea C; Kaplan J. 1996. Natural killer cell recognition of self and non-self triggering antigens on normal lymphoblasts. Cell Immunol 173(1):33-48. [PubMed: 8871599]  [MGI Ref ID J:35841]

Hobbs NK; Bondareva AA; Barnett S; Capecchi MR; Schmidt EE. 2002. Removing the Vertebrate-Specific TBP N Terminus Disrupts Placental beta2m-Dependent Interactions with the Maternal Immune System. Cell 110(1):43-54. [PubMed: 12150996]  [MGI Ref ID J:77714]

Hoglund P; Glas R; Menard C; Kase A; Johansson MH; Franksson L; Lemmonier F; Karre K. 1998. Beta2-microglobulin-deficient NK cells show increased sensitivity to MHC class I-mediated inhibition, but self tolerance does not depend upon target cell expression of H-2Kb and Db heavy chains. Eur J Immunol 28(1):370-8. [PubMed: 9485216]  [MGI Ref ID J:45905]

Hogquist KA; Gavin MA; Bevan MJ. 1993. Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture. J Exp Med 177(5):1469-73. [PubMed: 8478616]  [MGI Ref ID J:77013]

Hsieh SH; Lin JS; Huang JH; Wu SY; Chu CL; Kung JT; Wu-Hsieh BA. 2011. Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis. Infect Immun 79(11):4493-502. [PubMed: 21911464]  [MGI Ref ID J:177771]

Huang GJ; Smith AL; Gray DH; Cosgrove C; Singer BH; Edwards A; Sim S; Parent JM; Johnsen A; Mott R; Mathis D; Klenerman P; Benoist C; Flint J. 2010. A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus. PLoS Biol 8(12):e1000561. [PubMed: 21179499]  [MGI Ref ID J:170591]

Huang W; Hu J; August A. 2013. Cutting Edge: Innate Memory CD8+ T Cells Are Distinct from Homeostatic Expanded CD8+ T Cells and Rapidly Respond to Primary Antigenic Stimuli. J Immunol 190(6):2490-4. [PubMed: 23408840]  [MGI Ref ID J:193676]

Iizuka K; Scalzo AA; Xian H; Yokoyama WM. 2008. Regulation of the NK cell alloreactivity to bone marrow cells by the combination of the host NK gene complex and MHC haplotypes. J Immunol 180(5):3260-7. [PubMed: 18292550]  [MGI Ref ID J:131556]

Ismail N; Crossley EC; Stevenson HL; Walker DH. 2007. Relative importance of T-cell subsets in monocytotropic ehrlichiosis: a novel effector mechanism involved in ehrlichia-induced immunopathology in murine ehrlichiosis. Infect Immun 75(9):4608-20. [PubMed: 17562770]  [MGI Ref ID J:123934]

Ito M; Hiramatsu H; Kobayashi K; Suzue K; Kawahata M; Hioki K; Ueyama Y; Koyanagi Y; Sugamura K; Tsuji K; Heike T; Nakahata T. 2002. NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood 100(9):3175-82. [PubMed: 12384415]  [MGI Ref ID J:163373]

Jarchum I; Baker JC; Yamada T; Takaki T; Marron MP; Serreze DV; DiLorenzo TP. 2007. In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A*0201 transgenic NOD mice. Diabetes 56(10):2551-60. [PubMed: 17620420]  [MGI Ref ID J:126569]

Jarchum I; DiLorenzo TP. 2010. Ins2 deficiency augments spontaneous HLA-A*0201-restricted T cell responses to insulin. J Immunol 184(2):658-65. [PubMed: 19966211]  [MGI Ref ID J:159429]

Jay DC; Reed-Loisel LM; Jensen PE. 2008. Polyclonal MHC Ib-Restricted CD8+ T Cells Undergo Homeostatic Expansion in the Absence of Conventional MHC-Restricted T Cells. J Immunol 180(5):2805-14. [PubMed: 18292501]  [MGI Ref ID J:131725]

Jin Y; Xia M; Saylor CM; Narayan K; Kang J; Wiest DL; Wang Y; Xiong N. 2010. Cutting edge: Intrinsic programming of thymic gammadeltaT cells for specific peripheral tissue localization. J Immunol 185(12):7156-60. [PubMed: 21068400]  [MGI Ref ID J:167476]

Joetham A; Takeda K; Miyahara N; Matsubara S; Ohnishi H; Koya T; Dakhama A; Gelfand EW. 2007. Activation of naturally occurring lung CD4+CD25+ regulatory T cells requires CD8 and MHC I interaction. Proc Natl Acad Sci U S A 104(38):15057-62. [PubMed: 17855564]  [MGI Ref ID J:125195]

Jordan MB; Hildeman D; Kappler J; Marrack P. 2004. An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder. Blood 104(3):735-43. [PubMed: 15069016]  [MGI Ref ID J:92260]

Joyce S; Negishi I; Boesteanu A; DeSilva AD; Sharma P; Chorney MJ; Loh DY; Van Kaer L. 1996. Expansion of natural (NK1+) T cells that express alpha beta T cell receptors in transporters associated with antigen presentation-1 null and thymus leukemia antigen positive mice. J Exp Med 184(4):1579-84. [PubMed: 8879233]  [MGI Ref ID J:110770]

Junghans RP; Anderson CL. 1996. The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor. Proc Natl Acad Sci U S A 93(11):5512-6. [PubMed: 8643606]  [MGI Ref ID J:39252]

Kaba SA; McCoy ME; Doll TA; Brando C; Guo Q; Dasgupta D; Yang Y; Mittelholzer C; Spaccapelo R; Crisanti A; Burkhard P; Lanar DE. 2012. Protective antibody and CD8+ T-cell responses to the Plasmodium falciparum circumsporozoite protein induced by a nanoparticle vaccine. PLoS One 7(10):e48304. [PubMed: 23144750]  [MGI Ref ID J:192356]

Kamizono S; Duncan GS; Seidel MG; Morimoto A; Hamada K; Grosveld G; Akashi K; Lind EF; Haight JP; Ohashi PS; Look AT; Mak TW. 2009. Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo. J Exp Med 206(13):2977-86. [PubMed: 19995955]  [MGI Ref ID J:155677]

Kassiotis G; Bauer J; Akassoglou K; Lassmann H; Kollias G; Probert L. 1999. A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice. Eur J Immunol 29(3):912-7. [PubMed: 10092095]  [MGI Ref ID J:53471]

Kastenmuller W; Gasteiger G; Gronau JH; Baier R; Ljapoci R; Busch DH; Drexler I. 2007. Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccination. J Exp Med 204(9):2187-98. [PubMed: 17709425]  [MGI Ref ID J:126086]

Kastenmuller W; Torabi-Parizi P; Subramanian N; Lammermann T; Germain RN. 2012. A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread. Cell 150(6):1235-48. [PubMed: 22980983]  [MGI Ref ID J:187962]

Katz J; Benoist C; Mathis D. 1993. Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice. Eur J Immunol 23(12):3358-60. [PubMed: 8258349]  [MGI Ref ID J:93557]

Kawabata H; Niwa A; Tsuji-Kawahara S; Uenishi H; Iwanami N; Matsukuma H; Abe H; Tabata N; Matsumura H; Miyazawa M. 2006. Peptide-induced immune protection of CD8+ T cell-deficient mice against Friend retrovirus-induced disease. Int Immunol 18(1):183-98. [PubMed: 16352628]  [MGI Ref ID J:104156]

Kawahara A; Kurauchi S; Fukata Y; Martinez-Hernandez J; Yagihashi T; Itadani Y; Sho R; Kajiyama T; Shinzato N; Narusuye K; Fukata M; Lujan R; Shigemoto R; Ito I. 2013. Neuronal major histocompatibility complex class I molecules are implicated in the generation of asymmetries in hippocampal circuitry. J Physiol 591(Pt 19):4777-91. [PubMed: 23878366]  [MGI Ref ID J:214174]

Kawano M; Nakayama M; Aoshima Y; Nakamura K; Ono M; Nishiya T; Nakamura S; Takeda Y; Dobashi A; Takahashi A; Endo M; Ito A; Ueda K; Sato N; Higuchi S; Kondo T; Hashimoto S; Watanabe M; Watanabe M; Takahashi T; Sasaki K; Nakamura M; Sasazuki T; Narushima T; Suzuki R; Ogasawara K. 2014. NKG2D(+) IFN-gamma(+) CD8(+) T cells are responsible for palladium allergy. PLoS One 9(2):e86810. [PubMed: 24533050]  [MGI Ref ID J:212941]

Keefe R; Dave V; Allman D; Wiest D; Kappes DJ. 1999. Regulation of lineage commitment distinct from positive selection. Science 286(5442):1149-53. [PubMed: 10550051]  [MGI Ref ID J:124533]

Kehren J; Desvignes C; Krasteva M; Ducluzeau MT; Assossou O; Horand F; Hahne M; Kagi D; Kaiserlian D; Nicolas JF. 1999. Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity. J Exp Med 189(5):779-86. [PubMed: 10049941]  [MGI Ref ID J:112018]

Kerkar SP; Goldszmid RS; Muranski P; Chinnasamy D; Yu Z; Reger RN; Leonardi AJ; Morgan RA; Wang E; Marincola FM; Trinchieri G; Rosenberg SA; Restifo NP. 2011. IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors. J Clin Invest 121(12):4746-57. [PubMed: 22056381]  [MGI Ref ID J:184027]

Kerksiek KM; Niedergang F; Chavrier P; Busch DH; Brocker T. 2005. Selective Rac1 inhibition in dendritic cells diminishes apoptotic cell uptake and cross-presentation in vivo. Blood 105(2):742-9. [PubMed: 15383465]  [MGI Ref ID J:96564]

Khan S; Bijker MS; Weterings JJ; Tanke HJ; Adema GJ; van Hall T; Drijfhout JW; Melief CJ; Overkleeft HS; van der Marel GA; Filippov DV; van der Burg SH; Ossendorp F. 2007. Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells. J Biol Chem 282(29):21145-59. [PubMed: 17462991]  [MGI Ref ID J:124553]

Khare SD; Lee S; Bull MJ; Hanson J; Luthra HS; David CS. 2001. Spontaneous inflammatory disease in HLA-B27 transgenic mice does not require transporter of antigenic peptides. Clin Immunol 98(3):364-9. [PubMed: 11237560]  [MGI Ref ID J:115586]

Khare SD; Luthra HS; David CS. 1995. Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin: a model of human spondyloarthropathies. J Exp Med 182(4):1153-8. [PubMed: 7561688]  [MGI Ref ID J:110767]

Kieper WC; Tan JT; Bondi-Boyd B; Gapin L; Sprent J; Ceredig R; Surh CD. 2002. Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells. J Exp Med 195(12):1533-9. [PubMed: 12070281]  [MGI Ref ID J:132582]

Kim S; Li L; McMurtrey CP; Hildebrand WH; Weidanz JA; Gillanders WE; Diamond MS; Hansen TH. 2010. Single-chain HLA-A2 MHC trimers that incorporate an immundominant peptide elicit protective T cell immunity against lethal West Nile virus infection. J Immunol 184(8):4423-30. [PubMed: 20212098]  [MGI Ref ID J:190226]

Kimura MY; Pobezinsky LA; Guinter TI; Thomas J; Adams A; Park JH; Tai X; Singer A. 2013. IL-7 signaling must be intermittent, not continuous, during CD8(+) T cell homeostasis to promote cell survival instead of cell death. Nat Immunol 14(2):143-51. [PubMed: 23242416]  [MGI Ref ID J:192537]

Kimura T; Griffin DE. 2000. The role of CD8(+) T cells and major histocompatibility complex class I expression in the central nervous system of mice infected with neurovirulent Sindbis virus. J Virol 74(13):6117-25. [PubMed: 10846095]  [MGI Ref ID J:126435]

King MA; Covassin L; Brehm MA; Racki W; Pearson T; Leif J; Laning J; Fodor W; Foreman O; Burzenski L; Chase TH; Gott B; Rossini AA; Bortell R; Shultz LD; Greiner DL. 2009. Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex. Clin Exp Immunol 157(1):104-18. [PubMed: 19659776]  [MGI Ref ID J:151390]

Kingsbury DJ; Mear JP; Witte DP; Taurog JD; Roopenian DC; Colbert RA. 2000. Development of spontaneous arthritis in beta2-microglobulin-deficient mice without expression of HLA-B27: association with deficiency of endogenous major histocompatibility complex class I expression. Arthritis Rheum 43(10):2290-6. [PubMed: 11037889]  [MGI Ref ID J:133830]

Kirby AC; Yrlid U; Svensson M; Wick MJ. 2001. Differential involvement of dendritic cell subsets during acute salmonella infection. J Immunol 166(11):6802-11. [PubMed: 11359839]  [MGI Ref ID J:69480]

Kirchenbaum GA; St Clair JB; Detanico T; Aviszus K; Wysocki LJ. 2014. Functionally responsive self-reactive B cells of low affinity express reduced levels of surface IgM. Eur J Immunol 44(4):970-82. [PubMed: 24375379]  [MGI Ref ID J:209415]

Klezovich-Benard M; Corre JP; Jusforgues-Saklani H; Fiole D; Burjek N; Tournier JN; Goossens PL. 2012. Mechanisms of NK cell-macrophage Bacillus anthracis crosstalk: a balance between stimulation by spores and differential disruption by toxins. PLoS Pathog 8(1):e1002481. [PubMed: 22253596]  [MGI Ref ID J:195407]

Kobayashi S; Yoshida K; Ward JM; Letterio JJ; Longenecker G; Yaswen L; Mittleman B; Mozes E; Roberts AB; Karlsson S; Kulkarni AB. 1999. Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse. J Immunol 163(7):4013-9. [PubMed: 10491004]  [MGI Ref ID J:110828]

Kobrynski LJ; Sousa AO; Nahmias AJ; Lee FK. 2005. Cutting edge: antibody production to pneumococcal polysaccharides requires CD1 molecules and CD8+ T cells. J Immunol 174(4):1787-90. [PubMed: 15699104]  [MGI Ref ID J:96541]

Koh YI; Kim HY; Meyer EH; Pichavant M; Akbari O; Yasumi T; Savage PB; Dekruyff RH; Umetsu DT. 2008. Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta2-microglobulin-deficient mice. J Immunol 181(7):4560-9. [PubMed: 18802058]  [MGI Ref ID J:141297]

Kohu K; Sato T; Ohno S; Hayashi K; Uchino R; Abe N; Nakazato M; Yoshida N; Kikuchi T; Iwakura Y; Inoue Y; Watanabe T; Habu S; Satake M. 2005. Overexpression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single-positive lineage. J Immunol 174(5):2627-36. [PubMed: 15728469]  [MGI Ref ID J:97715]

Koller BH; Smithies O. 1989. Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination. Proc Natl Acad Sci U S A 86(22):8932-5. [PubMed: 2682666]  [MGI Ref ID J:65612]

Koltun M; Nikolovski J; Strong K; Nikolic-Paterson D; Comper WD. 2005. Mechanism of hypoalbuminemia in rodents. Am J Physiol Heart Circ Physiol 288(4):H1604-10. [PubMed: 15539420]  [MGI Ref ID J:97362]

Konishi J; Iwabuchi K; Iwabuchi C; Ato M; Nagata JI; Onoe K; Nakagawa KI; Kasai M; Ogasawara K; Kawakami K; Onoe K. 2000. Thymic epithelial cells responsible for impaired generation of NK-T thymocytes in Alymphoplasia mutant mice. Cell Immunol 206(1):26-35. [PubMed: 11161435]  [MGI Ref ID J:67083]

Kostek CA; Dominov JA; Miller JB. 2002. Up-regulation of MHC class I expression accompanies but is not required for spontaneous myopathy in dysferlin-deficient SJL/J mice. Am J Pathol 160(3):833-9. [PubMed: 11891182]  [MGI Ref ID J:75304]

Koyama M; Hashimoto D; Aoyama K; Matsuoka K; Karube K; Niiro H; Harada M; Tanimoto M; Akashi K; Teshima T. 2009. Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen-presenting cells. Blood 113(9):2088-95. [PubMed: 19144988]  [MGI Ref ID J:146164]

Krawczyk C; Oliveira-dos-Santos A; Sasaki T; Griffiths E; Ohashi PS; Snapper S; Alt F; Penninger JM. 2002. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity 16(3):331-43. [PubMed: 11911819]  [MGI Ref ID J:111206]

Kunisaki Y; Tanaka Y; Sanui T; Inayoshi A; Noda M; Nakayama T; Harada M; Taniguchi M; Sasazuki T; Fukui Y. 2006. DOCK2 is required in T cell precursors for development of Valpha14 NK T cells. J Immunol 176(8):4640-5. [PubMed: 16585555]  [MGI Ref ID J:131163]

Lacorazza HD; Nikolich-Zugich J. 2004. Exclusion and inclusion of TCR alpha proteins during T cell development in TCR-transgenic and normal mice. J Immunol 173(9):5591-600. [PubMed: 15494509]  [MGI Ref ID J:132808]

Lamouse-Smith E; McCarthy SA. 1997. Allospecific cytotoxic T cells generated from beta 2m-/- mice in primary MLC: analysis of activation requirements, specificity, and phenotype. Cell Immunol 179(2):107-15. [PubMed: 9268494]  [MGI Ref ID J:42696]

Larena M; Prow NA; Hall RA; Petrovsky N; Lobigs M. 2013. JE-ADVAX vaccine protection against Japanese encephalitis virus mediated by memory B cells in the absence of CD8(+) T cells and pre-exposure neutralizing antibody. J Virol 87(8):4395-402. [PubMed: 23388724]  [MGI Ref ID J:197217]

Lau LL; Spain LM. 2000. Altered aging-related thymic involution in T cell receptor transgenic, MHC-deficient, and CD4-deficient mice. Mech Ageing Dev 114(2):101-21. [PubMed: 10799708]  [MGI Ref ID J:111547]

Lavi E; Das Sarma J; Weiss SR. 1999. Cellular reservoirs for coronavirus infection of the brain in beta2-microglobulin knockout mice. Pathobiology 67(2):75-83. [PubMed: 10023135]  [MGI Ref ID J:54035]

Lawson VJ; Maurice D; Silk JD; Cerundolo V; Weston K. 2009. Aberrant selection and function of invariant NKT cells in the absence of AP-1 transcription factor Fra-2. J Immunol 183(4):2575-84. [PubMed: 19620306]  [MGI Ref ID J:151549]

Lee BO; Jones JE; Peters CJ; Whitacre D; Frelin L; Hughes J; Kim WK; Milich DR. 2011. Identification of a unique double-negative regulatory T-cell population. Immunology 134(4):434-47. [PubMed: 22044159]  [MGI Ref ID J:178639]

Lee CC; Kung JT. 2012. Marginal zone B cell is a major source of Il-10 in Listeria monocytogenes susceptibility. J Immunol 189(7):3319-27. [PubMed: 22933629]  [MGI Ref ID J:190348]

Lee JW; Epardaud M; Sun J; Becker JE; Cheng AC; Yonekura AR; Heath JK; Turley SJ. 2007. Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat Immunol 8(2):181-90. [PubMed: 17195844]  [MGI Ref ID J:117862]

Leite-de-Moraes MC; Herbelin A; Gombert JM; Vicari A; Papiernik M ; Dy M. 1997. Requirement of IL-7 for IL-4-producing potential of MHC class I-selected CD4-CD8-TCR alpha beta+ thymocytes. Int Immunol 9(1):73-9. [PubMed: 9043949]  [MGI Ref ID J:40708]

Levy JE; Montross LK; Andrews NC. 2000. Genes that modify the hemochromatosis phenotype in mice [see comments] J Clin Invest 105(9):1209-16. [PubMed: 10791995]  [MGI Ref ID J:62112]

Li L; Sullivan BA; Aldrich CJ; Soloski MJ; Forman J; Grandea AG 3rd; Jensen PE; Van Kaer L. 2004. Differential requirement for tapasin in the presentation of leader- and insulin-derived peptide antigens to Qa-1b-restricted CTLs. J Immunol 173(6):3707-15. [PubMed: 15356116]  [MGI Ref ID J:92768]

Li LP; Lampert JC; Chen X; Leitao C; Popovic J; Muller W; Blankenstein T. 2010. Transgenic mice with a diverse human T cell antigen receptor repertoire. Nat Med 16(9):1029-34. [PubMed: 20693993]  [MGI Ref ID J:164445]

Li W; Murthy AK; Guentzel MN; Seshu J; Forsthuber TG; Zhong G; Arulanandam BP. 2008. Antigen-Specific CD4+ T Cells Produce Sufficient IFN-{gamma} to Mediate Robust Protective Immunity against Genital Chlamydia muridarum Infection. J Immunol 180(5):3375-82. [PubMed: 18292563]  [MGI Ref ID J:131578]

Liebler JM; Lutzko C; Banfalvi A; Senadheera D; Aghamohammadi N; Crandall ED; Borok Z. 2008. Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol 295(2):L285-92. [PubMed: 18515407]  [MGI Ref ID J:138638]

Lin JS; Yang CW; Wang DW; Wu-Hsieh BA. 2005. Dendritic cells cross-present exogenous fungal antigens to stimulate a protective CD8 T cell response in infection by Histoplasma capsulatum. J Immunol 174(10):6282-91. [PubMed: 15879127]  [MGI Ref ID J:109987]

Linette GP; Grusby MJ; Hedrick SM; Hansen TH; Glimcher LH; Korsmeyer SJ. 1994. Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. Immunity 1(3):197-205. [PubMed: 7889408]  [MGI Ref ID J:81144]

Liu T; Chambers B; Diehl AD; Van Kaer L; Jondal M; Ljunggren HG. 1997. TAP peptide transporter-independent presentation of heat-killed Sendai virus antigen on MHC class I molecules by splenic antigen-presenting cells. J Immunol 159(11):5364-71. [PubMed: 9548476]  [MGI Ref ID J:110663]

Ljunggren HG; Van Kaer L; Ashton-Rickardt PG; Tonegawa S; Ploegh HL. 1995. Differential reactivity of residual CD8+ T lymphocytes in TAP1 and beta 2-microglobulin mutant mice. Eur J Immunol 25(1):174-8. [PubMed: 7843229]  [MGI Ref ID J:22500]

Ljunggren HG; Van Kaer L; Sabatine MS; Auchincloss H Jr; Tonegawa S; Ploegh HL. 1995. MHC class I expression and CD8+ T cell development in TAP1/beta 2-microglobulin double mutant mice. Int Immunol 7(6):975-84. [PubMed: 7577806]  [MGI Ref ID J:26520]

Loconto J; Papes F; Chang E; Stowers L; Jones EP; Takada T; Kumanovics A; Lindahl KF; Dulac C. 2003. Functional Expression of Murine V2R Pheromone Receptors Involves Selective Association with the M10 and M1 Families of MHC Class Ib Molecules. Cell 112(5):607-18. [PubMed: 12628182]  [MGI Ref ID J:82444]

Logunova NN; Viret C; Pobezinsky LA; Miller SA; Kazansky DB; Sundberg JP; Chervonsky AV. 2005. Restricted MHC-peptide repertoire predisposes to autoimmunity. J Exp Med 202(1):73-84. [PubMed: 15998789]  [MGI Ref ID J:100625]

Loirat D; Mancini-Bourgine M; Abastado JP; Michel ML. 2003. HBsAg/HLA-A2 transgenic mice: a model for T cell tolerance to hepatitis B surface antigen in chronic hepatitis B virus infection. Int Immunol 15(10):1125-36. [PubMed: 13679383]  [MGI Ref ID J:85801]

Lowin-Kropf B; Kunz B; Beermann F; Held W. 2000. Impaired natural killing of MHC class I-deficient targets by NK cells expressing a catalytically inactive form of SHP-1. J Immunol 165(3):1314-21. [PubMed: 10903732]  [MGI Ref ID J:120439]

Lowin-Kropf B; Kunz B; Schneider P; Held W. 2002. A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors. Eur J Immunol 32(3):773-82. [PubMed: 11870621]  [MGI Ref ID J:108602]

Ma G; Pan PY; Eisenstein S; Divino CM; Lowell CA; Takai T; Chen SH. 2011. Paired Immunoglobin-like Receptor-B Regulates the Suppressive Function and Fate of Myeloid-Derived Suppressor Cells. Immunity 34(3):385-95. [PubMed: 21376641]  [MGI Ref ID J:170325]

Maeda M; Shadeo A; MacFadyen AM; Takei F. 2004. CD1d-independent NKT cells in beta 2-microglobulin-deficient mice have hybrid phenotype and function of NK and T cells. J Immunol 172(10):6115-22. [PubMed: 15128797]  [MGI Ref ID J:132824]

Maldonado MA; Eisenberg RA; Roper E; Cohen PL; Kotzin BL. 1995. Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility complex class I. J Exp Med 181(2):641-8. [PubMed: 7530760]  [MGI Ref ID J:22506]

Maldonado MA; MacDonald GC; Kakkanaiah VN; Fecho K; Dransfield M; Sekiguchi D; Cohen PL; Eisenberg RA. 1999. Differential control of autoantibodies and lymphoproliferation by Fas ligand expression on CD4+ and CD8+ T cells in vivo. J Immunol 163(6):3138-42. [PubMed: 10477580]  [MGI Ref ID J:119603]

Marguerat S; MacDonald HR; Kraehenbuhl JP; van Meerwijk JP. 1999. Protection from radiation-induced colitis requires MHC class II antigen expression by cells of hemopoietic origin. J Immunol 163(7):4033-40. [PubMed: 10491007]  [MGI Ref ID J:119199]

Marron MP; Graser RT; Chapman HD; Serreze DV. 2002. Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice. Proc Natl Acad Sci U S A 99(21):13753-8. [PubMed: 12361980]  [MGI Ref ID J:109851]

Marshall HD; Prince AL; Berg LJ; Welsh RM. 2010. IFN-alphabeta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions. J Immunol 185(3):1419-28. [PubMed: 20592282]  [MGI Ref ID J:162457]

Martin B; Becourt C; Bienvenu B; Lucas B. 2006. Self-recognition is crucial for maintaining the peripheral CD4+ T-cell pool in a nonlymphopenic environment. Blood 108(1):270-7. [PubMed: 16527889]  [MGI Ref ID J:135378]

Martin B; Bourgeois C; Dautigny N; Lucas B. 2003. On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cells. Proc Natl Acad Sci U S A 100(10):6021-6. [PubMed: 12719530]  [MGI Ref ID J:126900]

Masuda A; Nakamura A; Maeda T; Sakamoto Y; Takai T. 2007. Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation. J Exp Med 204(4):907-20. [PubMed: 17420263]  [MGI Ref ID J:125576]

Matte CC; Liu J; Cormier J; Anderson BE; Athanasiadis I; Jain D; McNiff J; Shlomchik WD. 2004. Donor APCs are required for maximal GVHD but not for GVL. Nat Med 10(9):987-92. [PubMed: 15286785]  [MGI Ref ID J:92850]

Matte-Martone C; Liu J; Jain D; McNiff J; Shlomchik WD. 2008. CD8+ but not CD4+ T cells require cognate interactions with target tissues to mediate GVHD across only minor H antigens, whereas both CD4+ and CD8+ T cells require direct leukemic contact to mediate GVL. Blood 111(7):3884-92. [PubMed: 18223170]  [MGI Ref ID J:133502]

Maurice D; Hooper J; Lang G; Weston K. 2007. c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3. EMBO J 26(15):3629-40. [PubMed: 17641686]  [MGI Ref ID J:124106]

Maurice MM; Gould DS; Carroll J; Vugmeyster Y; Ploegh HL. 2001. Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules. Proc Natl Acad Sci U S A 98(13):7437-42. [PubMed: 11404484]  [MGI Ref ID J:70614]

McCaughtry TM; Etzensperger R; Alag A; Tai X; Kurtulus S; Park JH; Grinberg A; Love P; Feigenbaum L; Erman B; Singer A. 2012. Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus. J Exp Med 209(12):2263-76. [PubMed: 23109710]  [MGI Ref ID J:190889]

McPhee CG; Sproule TJ; Shin DM; Bubier JA; Schott WH; Steinbuck MP; Avenesyan L; Morse HC 3rd; Roopenian DC. 2011. MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis. J Immunol 187(9):4695-704. [PubMed: 21964024]  [MGI Ref ID J:179430]

Meissner NN; Lund FE; Han S; Harmsen A. 2005. CD8 T cell-mediated lung damage in response to the extracellular pathogen pneumocystis is dependent on MHC class I expression by radiation-resistant lung cells. J Immunol 175(12):8271-9. [PubMed: 16339567]  [MGI Ref ID J:122256]

Mendiratta SK; Kovalik JP; Hong S; Singh N; Martin WD; Van Kaer L. 1999. Peptide dependency of alloreactive CD4+ T cell responses. Int Immunol 11(3):351-60. [PubMed: 10221647]  [MGI Ref ID J:110542]

Mezo AR; McDonnell KA; Hehir CA; Low SC; Palombella VJ; Stattel JM; Kamphaus GD; Fraley C; Zhang Y; Dumont JA; Bitonti AJ. 2008. Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn. Proc Natl Acad Sci U S A 105(7):2337-42. [PubMed: 18272495]  [MGI Ref ID J:132181]

Mintern JD; Maurice MM; Ploegh HL; Schott E. 2004. Thymic selection and peripheral activation of CD8 T cells by the same class I MHC/peptide complex. J Immunol 172(1):699-708. [PubMed: 14688383]  [MGI Ref ID J:87075]

Mitchell AJ; Hansen AM; Hee L; Ball HJ; Potter SM; Walker JC; Hunt NH. 2005. Early cytokine production is associated with protection from murine cerebral malaria. Infect Immun 73(9):5645-53. [PubMed: 16113282]  [MGI Ref ID J:100415]

Mohammed JP; Fusakio ME; Rainbow DB; Moule C; Fraser HI; Clark J; Todd JA; Peterson LB; Savage PB; Wills-Karp M; Ridgway WM; Wicker LS; Mattner J. 2011. Identification of Cd101 as a susceptibility gene for Novosphingobium aromaticivorans-induced liver autoimmunity. J Immunol 187(1):337-49. [PubMed: 21613619]  [MGI Ref ID J:175942]

Moos T; Trinder D; Morgan EH. 2002. Effect of iron status on DMT1 expression in duodenal enterocytes from beta2-microglobulin knockout mice. Am J Physiol Gastrointest Liver Physiol 283(3):G687-94. [PubMed: 12181184]  [MGI Ref ID J:78896]

Moro H; Otero DC; Tanabe Y; David M. 2011. T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival. PLoS One 6(9):e24972. [PubMed: 21949815]  [MGI Ref ID J:177873]

Morris SC; Coffman RL; Finkelman FD. 1998. In vivo IL-4 responses to anti-IgD antibody are MHC class II dependent and beta 2-microglobulin independent and develop normally in the absence of IL-4 priming of T cells. J Immunol 160(7):3299-304. [PubMed: 9531287]  [MGI Ref ID J:111652]

Mott KR; Allen SJ; Zandian M; Konda B; Sharifi BG; Jones C; Wechsler SL; Town T; Ghiasi H. 2014. CD8alpha dendritic cells drive establishment of HSV-1 latency. PLoS One 9(4):e93444. [PubMed: 24695322]  [MGI Ref ID J:215038]

Mukherjee R; Zhang Z; Zhong R; Yin ZQ; Roopenian DC; Jevnikar AM. 1996. Lupus nephritis in the absence of renal major histocompatibility complex class I and class II molecules. J Am Soc Nephrol 7(11):2445-52. [PubMed: 8959638]  [MGI Ref ID J:39693]

Muller D; Koller BH; Whitton JL; LaPan KE; Brigman KK; Frelinger JA. 1992. LCMV-specific, class II-restricted cytotoxic T cells in beta 2-microglobulin-deficient mice. Science 255(5051):1576-8. [PubMed: 1347959]  [MGI Ref ID J:2765]

Muller D; Pakpreo P; Filla J; Pederson K; Cigel F; Malkovska V. 1995. Increased gamma-delta T-lymphocyte response to Mycobacterium bovis BCG in major histocompatibility complex class I-deficient mice. Infect Immun 63(6):2361-6. [PubMed: 7768622]  [MGI Ref ID J:111338]

Muller JR; Waldmann TA; Dubois S. 2012. Selective Dependence of H2-M3-Restricted CD8 Responses on IL-15. J Immunol 188(6):2575-82. [PubMed: 22312130]  [MGI Ref ID J:181860]

Murakami M; Paul WE. 1998. Age-dependent appearance of NK1.1+ T cells in the livers of beta2-microglobulin knockout and SJL mice. J Immunol 160(6):2649-54. [PubMed: 9510163]  [MGI Ref ID J:46188]

Murali-Krishna K; Ahmed R. 2000. Cutting edge: naive T cells masquerading as memory cells. J Immunol 165(4):1733-7. [PubMed: 10925249]  [MGI Ref ID J:120420]

Murali-Krishna K; Lau LL; Sambhara S; Lemonnier F; Altman J; Ahmed R. 1999. Persistence of memory CD8 T cells in MHC class I-deficient mice [see comments] Science 286(5443):1377-81. [PubMed: 10558996]  [MGI Ref ID J:58469]

Muroi S; Naoe Y; Miyamoto C; Akiyama K; Ikawa T; Masuda K; Kawamoto H; Taniuchi I. 2008. Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate. Nat Immunol 9(10):1113-21. [PubMed: 18776907]  [MGI Ref ID J:141142]

Muroi S; Tanaka H; Miyamoto C; Taniuchi I. 2013. Cutting edge: fine-tuning of thpok gene activation by an enhancer in close proximity to its own silencer. J Immunol 190(4):1397-401. [PubMed: 23315079]  [MGI Ref ID J:193321]

Nagarajan NA; Gonzalez F; Shastri N. 2012. Nonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum. Nat Immunol 13(6):579-86. [PubMed: 22522492]  [MGI Ref ID J:186455]

Nakajima S; Hida S; Taki S. 2008. IL-15 inhibits pre-B cell proliferation by selectively expanding Mac-1+B220+ NK cells. Biochem Biophys Res Commun 369(4):1139-43. [PubMed: 18339305]  [MGI Ref ID J:134069]

Nasreen M; Ueno T; Saito F; Takahama Y. 2003. In vivo treatment of class II MHC-deficient mice with anti-TCR antibody restores the generation of circulating CD4 T cells and optimal architecture of thymic medulla. J Immunol 171(7):3394-400. [PubMed: 14500633]  [MGI Ref ID J:120396]

Niens M; Grier AE; Marron M; Kay TW; Greiner DL; Serreze DV. 2011. Prevention of 'Humanized' diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach. Diabetes 60(4):1229-36. [PubMed: 21346176]  [MGI Ref ID J:171756]

Nitta T; Murata S; Sasaki K; Fujii H; Ripen AM; Ishimaru N; Koyasu S; Tanaka K; Takahama Y. 2010. Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells. Immunity 32(1):29-40. [PubMed: 20045355]  [MGI Ref ID J:157648]

Nitta T; Nitta S; Lei Y; Lipp M; Takahama Y. 2009. CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens. Proc Natl Acad Sci U S A 106(40):17129-33. [PubMed: 19805112]  [MGI Ref ID J:153692]

Noble A; Pestano GA; Cantor H. 1998. Suppression of immune responses by CD8 cells. I. Superantigen-activated CD8 cells induce unidirectional Fas-mediated apoptosis of antigen-activated CD4 cells. J Immunol 160(2):559-65. [PubMed: 9551888]  [MGI Ref ID J:45187]

Noble A; Zhao ZS; Cantor H. 1998. Suppression of immune responses by CD8 cells. II. Qa-1 on activated B cells stimulates CD8 cell suppression of T helper 2 responses. J Immunol 160(2):566-71. [PubMed: 9551889]  [MGI Ref ID J:45188]

Oberg L; Johansson S; Michaelsson J; Tomasello E; Vivier E; Karre K; Hoglund P. 2004. Loss or mismatch of MHC class I is sufficient to trigger NK cell-mediated rejection of resting lymphocytes in vivo - role of KARAP/DAP12-dependent and -independent pathways. Eur J Immunol 34(6):1646-53. [PubMed: 15162434]  [MGI Ref ID J:115484]

Ochi A; Nguyen AH; Bedrosian AS; Mushlin HM; Zarbakhsh S; Barilla R; Zambirinis CP; Fallon NC; Rehman A; Pylayeva-Gupta Y; Badar S; Hajdu CH; Frey AB; Bar-Sagi D; Miller G. 2012. MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. J Exp Med 209(9):1671-87. [PubMed: 22908323]  [MGI Ref ID J:191814]

Ohmura K; Ishimori N; Ohmura Y; Tokuhara S; Nozawa A; Horii S; Andoh Y; Fujii S; Iwabuchi K; Onoe K; Tsutsui H. 2010. Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice. Arterioscler Thromb Vasc Biol 30(2):193-9. [PubMed: 19910631]  [MGI Ref ID J:172110]

Okamoto N; Kanie O; Huang YY; Fujii R; Watanabe H; Shimamura M. 2005. Synthetic alpha-mannosyl ceramide as a potent stimulant for an NKT cell repertoire bearing the invariant Valpha19-Jalpha26 TCR alpha chain. Chem Biol 12(6):677-83. [PubMed: 15975513]  [MGI Ref ID J:140924]

Oliveira AL; Thams S; Lidman O; Piehl F; Hokfelt T; Karre K; Linda H; Cullheim S. 2004. A role for MHC class I molecules in synaptic plasticity and regeneration of neurons after axotomy. Proc Natl Acad Sci U S A 101(51):17843-8. [PubMed: 15591351]  [MGI Ref ID J:95276]

Oliveira GA; Kumar KA; Calvo-Calle JM; Othoro C; Altszuler D; Nussenzweig V; Nardin EH. 2008. Class II-restricted protective immunity induced by malaria sporozoites. Infect Immun 76(3):1200-6. [PubMed: 18160479]  [MGI Ref ID J:131605]

Oppenheim DE; Roberts SJ; Clarke SL; Filler R; Lewis JM; Tigelaar RE; Girardi M; Hayday AC. 2005. Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance. Nat Immunol 6(9):928-37. [PubMed: 16116470]  [MGI Ref ID J:100454]

Ortega SB; Kashi VP; Tyler AF; Cunnusamy K; Mendoza JP; Karandikar NJ. 2013. The disease-ameliorating function of autoregulatory CD8 T cells is mediated by targeting of encephalitogenic CD4 T cells in experimental autoimmune encephalomyelitis. J Immunol 191(1):117-26. [PubMed: 23733879]  [MGI Ref ID J:205352]

Osorio RW; Ascher NL; Melzer JS; Stock PG. 1994. beta-2 Microglobulin gene disruption prolongs murine islet allograft survival in NOD mice. Transplant Proc 26(2):752. [PubMed: 8171644]  [MGI Ref ID J:17881]

Pascolo S; Bervas N; Ure JM; Smith AG; Lemonnier FA; Perarnau B. 1997. HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice. J Exp Med 185(12):2043-51. [PubMed: 9182675]  [MGI Ref ID J:41077]

Patel R; Belanger S; Tai LH; Troke AD; Makrigiannis AP. 2010. Effect of Ly49 haplotype variance on NK cell function and education. J Immunol 185(8):4783-92. [PubMed: 20855875]  [MGI Ref ID J:164728]

Paterson RK; Burkly LC; Kurahara DK; Dunlap A; Flavell RA; Finkel TH. 1994. Thymic development in human CD4 transgenic mice. Positive selection occurs after commitment to the CD8 lineage. J Immunol 153(8):3491-503. [PubMed: 7930572]  [MGI Ref ID J:131345]

Peng Y; Shao H; Ke Y; Zhang P; Xiang J; Kaplan HJ; Sun D. 2006. In vitro activation of CD8 interphotoreceptor retinoid-binding protein-specific T cells requires not only antigenic stimulation but also exogenous growth factors. J Immunol 176(8):5006-14. [PubMed: 16585597]  [MGI Ref ID J:131181]

Persaud SP; Parker CR; Lo WL; Weber KS; Allen PM. 2014. Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC. Nat Immunol 15(3):266-74. [PubMed: 24487322]  [MGI Ref ID J:209799]

Peshes-Yaloz N; Rosen D; Sondel PM; Krammer PH; Berke G. 2007. Up-regulation of Fas (CD95) expression in tumour cells in vivo. Immunology 120(4):502-11. [PubMed: 17343612]  [MGI Ref ID J:122702]

Pobezinsky LA; Angelov GS; Tai X; Jeurling S; Van Laethem F; Feigenbaum L; Park JH; Singer A. 2012. Clonal deletion and the fate of autoreactive thymocytes that survive negative selection. Nat Immunol 13(6):569-78. [PubMed: 22544394]  [MGI Ref ID J:186451]

Popovic J; Li LP; Kloetzel PM; Leisegang M; Uckert W; Blankenstein T. 2011. The only proposed T-cell epitope derived from the TEL-AML1 translocation is not naturally processed. Blood 118(4):946-54. [PubMed: 21613253]  [MGI Ref ID J:174872]

Prajeeth CK; Haeberlein S; Sebald H; Schleicher U; Bogdan C. 2011. Leishmania-infected macrophages are targets of NK cell-derived cytokines but not of NK cell cytotoxicity. Infect Immun 79(7):2699-708. [PubMed: 21518784]  [MGI Ref ID J:173486]

Qi CF; Zhou JX; Lee CH; Naghashfar Z; Xiang S; Kovalchuk AL; Fredrickson TN; Hartley JW; Roopenian DC; Davidson WF; Janz S; Morse HC 3rd. 2007. Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. Cancer Res 67(6):2439-47. [PubMed: 17363561]  [MGI Ref ID J:120309]

Qian S; Fu F; Li Y; Gao L; Lu L; Noyola H; Rao AS; Thomson AW; Fung JJ. 1995. Presensitization by skin grafting from major histocompatibility complex class I or major histocompatibility complex class II deficient mice identifies class I antigens as inducers of allosensitization. Immunology 85(1):82-7. [PubMed: 7635525]  [MGI Ref ID J:25162]

Rafei M; Hardy MP; Williams P; Vanegas JR; Forner KA; Dulude G; Labrecque N; Galipeau J; Perreault C. 2011. Development and function of innate polyclonal TCRalphabeta+ CD8+ thymocytes. J Immunol 187(6):3133-44. [PubMed: 21844388]  [MGI Ref ID J:179243]

Rafei M; Rouette A; Brochu S; Vanegas JR; Perreault C. 2013. Differential effects of gammac cytokines on postselection differentiation of CD8 thymocytes. Blood 121(1):107-17. [PubMed: 23043071]  [MGI Ref ID J:192369]

Ranson T; Vosshenrich CA; Corcuff E; Richard O; Laloux V; Lehuen A; Di Santo JP. 2003. IL-15 availability conditions homeostasis of peripheral natural killer T cells. Proc Natl Acad Sci U S A 100(5):2663-8. [PubMed: 12598649]  [MGI Ref ID J:91423]

Ranson T; Vosshenrich CA; Corcuff E; Richard O; Muller W; Di Santo JP. 2003. IL-15 is an essential mediator of peripheral NK-cell homeostasis. Blood 101(12):4887-93. [PubMed: 12586624]  [MGI Ref ID J:132257]

Rifa'i M; Shi Z; Zhang SY; Lee YH; Shiku H; Isobe K; Suzuki H. 2008. CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-alphabetaTCR interaction and become IL-10-producing active regulatory cells. Int Immunol 20(7):937-47. [PubMed: 18495626]  [MGI Ref ID J:137065]

Riol-Blanco L; Lazarevic V; Awasthi A; Mitsdoerffer M; Wilson BS; Croxford A; Waisman A; Kuchroo VK; Glimcher LH; Oukka M. 2010. IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections. J Immunol 184(4):1710-20. [PubMed: 20083652]  [MGI Ref ID J:159487]

Rival C; Samy E; Setiady Y; Tung K. 2013. Cutting edge: Ly49C/I(-) neonatal NK cells predispose newborns to autoimmune ovarian disease induced by maternal autoantibody. J Immunol 191(6):2865-9. [PubMed: 23960238]  [MGI Ref ID J:205867]

Robertson NJ; Chai JG; Millrain M; Scott D; Hashim F; Manktelow E; Lemonnier F; Simpson E; Dyson J. 2007. Natural regulation of immunity to minor histocompatibility antigens. J Immunol 178(6):3558-65. [PubMed: 17339452]  [MGI Ref ID J:151739]

Rock F; Hadeler KP; Rammensee HG; Overath P. 2007. Quantitative analysis of mouse urine volatiles: in search of MHC-dependent differences. PLoS ONE 2(5):e429. [PubMed: 17487279]  [MGI Ref ID J:129348]

Rolph MS; Raupach B; Kobernick HH; Collins HL; Perarnau B; Lemonnier FA; Kaufmann SH. 2001. MHC class Ia-restricted T cells partially account for beta2-microglobulin-dependent resistance to Mycobacterium tuberculosis. Eur J Immunol 31(6):1944-9. [PubMed: 11433392]  [MGI Ref ID J:80887]

Rothenberg BE; Voland JR. 1996. beta2 knockout mice develop parenchymal iron overload: A putative role for class I genes of the major histocompatibility complex in iron metabolism. Proc Natl Acad Sci U S A 93(4):1529-34. [PubMed: 8643666]  [MGI Ref ID J:31732]

Rottenberg ME; Gigliotti Rothfuchs AC; Gigliotti D; Svanholm C; Bandholtz L; Wigzell H. 1999. Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice. J Immunol 162(5):2829-36. [PubMed: 10072530]  [MGI Ref ID J:124536]

Ru Z; Xiao W; Pajot A; Kou Z; Sun S; Maillere B; Zhao G; Ojcius DM; Lone YC; Zhou Y. 2012. Development of a humanized HLA-A2.1/DP4 transgenic mouse model and the use of this model to map HLA-DP4-restricted epitopes of HBV envelope protein. PLoS One 7(3):e32247. [PubMed: 22403638]  [MGI Ref ID J:186853]

Sakai Y; Tanaka Y; Yanagihara T; Watanabe M; Duan X; Terasawa M; Nishikimi A; Sanematsu F; Fukui Y. 2013. The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation. Blood 122(3):386-93. [PubMed: 23719299]  [MGI Ref ID J:201343]

Salcedo M; Andersson M; Lemieux S; Van Kaer L; Chambers BJ; Ljunggren HG. 1998. Fine tuning of natural killer cell specificity and maintenance of self tolerance in MHC class I-deficient mice. Eur J Immunol 28(4):1315-21. [PubMed: 9565371]  [MGI Ref ID J:114261]

Salcedo M; Diehl AD; Olsson-Alheim MY; Sundback J; Van Kaer L ; Karre K ; Ljunggren HG. 1997. Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice. J Immunol 158(7):3174-80. [PubMed: 9120271]  [MGI Ref ID J:39441]

Sanapala S; Yu JJ; Murthy AK; Li W; Guentzel MN; Chambers JP; Klose KE; Arulanandam BP. 2012. Perforin- and granzyme-mediated cytotoxic effector functions are essential for protection against Francisella tularensis following vaccination by the defined F. tularensis subsp. novicida DeltafopC vaccine strain. Infect Immun 80(6):2177-85. [PubMed: 22493083]  [MGI Ref ID J:186522]

Santos MM; de Sousa M; Rademakers LH; Clevers H; Marx JJ; Schilham MW. 2000. Iron overload and heart fibrosis in mice deficient for both ss2-microglobulin and rag1 Am J Pathol 157(6):1883-92. [PubMed: 11106561]  [MGI Ref ID J:66131]

Sarafova SD; Erman B; Yu Q; Van Laethem F; Guinter T; Sharrow SO; Feigenbaum L; Wildt KF; Ellmeier W; Singer A. 2005. Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity. Immunity 23(1):75-87. [PubMed: 16039581]  [MGI Ref ID J:100541]

Sarafova SD; Van Laethem F; Adoro S; Guinter T; Sharrow SO; Feigenbaum L; Singer A. 2009. Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice. Immunity 31(3):480-90. [PubMed: 19747858]  [MGI Ref ID J:152836]

Sasada T; Yang Y; Lai CC; Touma M; Clayton LK; Liu JH; Parisini E; Wang JH; Reinherz EL. 2003. Disparate peptide-dependent thymic selection outcomes in beta2M-deficient mice versus TAP-1-deficient mice: implications for repertoire formation. Eur J Immunol 33(2):368-80. [PubMed: 12645934]  [MGI Ref ID J:115696]

Sauder C; Hallensleben W; Pagenstecher A; Schneckenburger S; Biro L; Pertlik D; Hausmann J; Suter M; Staeheli P. 2000. Chemokine gene expression in astrocytes of Borna disease virus-infected rats and mice in the absence of inflammation. J Virol 74(19):9267-80. [PubMed: 10982374]  [MGI Ref ID J:64497]

Schaible UE; Collins HL; Priem F; Kaufmann SH. 2002. Correction of the Iron Overload Defect in beta-2-Microglobulin Knockout Mice by Lactoferrin Abolishes Their Increased Susceptibility to Tuberculosis. J Exp Med 196(11):1507-13. [PubMed: 12461085]  [MGI Ref ID J:80527]

Schmedt C; Tarakhovsky A. 2001. Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk). J Exp Med 193(7):815-26. [PubMed: 11283154]  [MGI Ref ID J:120548]

Schmidt D; Verdaguer J; Averill N; Santamaria P. 1997. A mechanism for the major histocompatibility complex-linked resistance to autoimmunity. J Exp Med 186(7):1059-75. [PubMed: 9314555]  [MGI Ref ID J:108768]

Scotto M; Afonso G; Larger E; Raverdy C; Lemonnier FA; Carel JC; Dubois-Laforgue D; Baz B; Levy D; Gautier JF; Launay O; Bruno G; Boitard C; Sechi LA; Hutton JC; Davidson HW; Mallone R. 2012. Zinc transporter (ZnT)8(186-194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients. Diabetologia 55(7):2026-31. [PubMed: 22526607]  [MGI Ref ID J:188655]

Sedger LM; Hou S; Osvath SR; Glaccum MB; Peschon JJ; van Rooijen N; Hyland L. 2002. Bone marrow B cell apoptosis during in vivo influenza virus infection requires TNF-alpha and lymphotoxin-alpha. J Immunol 169(11):6193-201. [PubMed: 12444124]  [MGI Ref ID J:118778]

Serreze DV; Leiter EH; Christianson GJ; Greiner D; Roopenian DC. 1994. Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant. Diabetes 43(3):505-9. [PubMed: 8314025]  [MGI Ref ID J:17000]

Serreze DV; Marron MP; Dilorenzo TP. 2007. 'Humanized' HLA transgenic NOD mice to identify pancreatic beta cell autoantigens of potential clinical relevance to type 1 diabetes. Ann N Y Acad Sci 1103:103-11. [PubMed: 17376821]  [MGI Ref ID J:123948]

Seymour BW; Gershwin LJ; Coffman RL. 1998. Aerosol-induced immunoglobulin (Ig)-E unresponsiveness to ovalbumin does not require CD8+ or T cell receptor (TCR)-gamma/delta+ T cells or interferon (IFN)-gamma in a murine model of allergen sensitization. J Exp Med 187(5):721-31. [PubMed: 9480982]  [MGI Ref ID J:46078]

Shah SA; Simpson SJ; Brown LF; Comiskey M; de Jong YP; Allen D; Terhorst C. 1998. Development of colonic adenocarcinomas in a mouse model of ulcerative colitis. Inflamm Bowel Dis 4(3):196-202. [PubMed: 9741021]  [MGI Ref ID J:51450]

Sherwood ER; Enoh VT; Murphey ED; Lin CY. 2004. Mice depleted of CD8+ T and NK cells are resistant to injury caused by cecal ligation and puncture. Lab Invest 84(12):1655-65. [PubMed: 15448711]  [MGI Ref ID J:110788]

Sherwood ER; Lin CY; Tao W; Hartmann CA; Dujon JE; French AJ; Varma TK. 2003. Beta 2 microglobulin knockout mice are resistant to lethal intraabdominal sepsis. Am J Respir Crit Care Med 167(12):1641-9. [PubMed: 12626348]  [MGI Ref ID J:103038]

Shi Z; Rifa'i M; Lee YH; Shiku H; Isobe K; Suzuki H. 2008. Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells. Immunology 124(1):121-8. [PubMed: 18205792]  [MGI Ref ID J:136528]

Shimamura M; Huang YY. 2002. Presence of a novel subset of NKT cells bearing an invariant V(alpha)19.1-J(alpha)26 TCR alpha chain. FEBS Lett 516(1-3):97-100. [PubMed: 11959111]  [MGI Ref ID J:109181]

Shimamura M; Huang YY; Kobayashi M; Goji H. 2009. Altered production of immunoregulatory cytokines by invariant Valpha19 TCR-bearing cells dependent on the duration and intensity of TCR engagement. Int Immunol 21(2):179-85. [PubMed: 19106232]  [MGI Ref ID J:144520]

Shimamura M; Huang YY; Okamoto N; Suzuki N; Yasuoka J; Morita K; Nishiyama A; Amano Y; Mishina T. 2007. Modulation of Valpha19 NKT cell immune responses by alpha-mannosyl ceramide derivatives consisting of a series of modified sphingosines. Eur J Immunol 37(7):1836-44. [PubMed: 17559170]  [MGI Ref ID J:146398]

Shultz LD; Ishikawa F; Greiner DL. 2007. Humanized mice in translational biomedical research. Nat Rev Immunol 7(2):118-30. [PubMed: 17259968]  [MGI Ref ID J:142414]

Simpson SJ; Mizoguchi E; Allen D; Bhan AK; Terhorst C. 1995. Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis. Eur J Immunol 25(9):2618-25. [PubMed: 7589135]  [MGI Ref ID J:39981]

Singer DS; Zinger H; Kohn LD; Mozes E. 1999. Differing MHC class I requirements for induction and propagation of experimental systemic lupus erythematosus. Eur J Immunol 29(7):2259-68. [PubMed: 10427989]  [MGI Ref ID J:115300]

Smith AL; Hayday AC. 2000. Genetic dissection of primary and secondary responses to a widespread natural pathogen of the gut, Eimeria vermiformis. Infect Immun 68(11):6273-80. [PubMed: 11035735]  [MGI Ref ID J:133107]

Smyth MJ; Snook MB. 1999. Perforin-dependent cytolytic responses in beta2-microglobulin-deficient mice. Cell Immunol 196(1):51-9. [PubMed: 10486155]  [MGI Ref ID J:57956]

Sohn KJ; Shah SA; Reid S; Choi M; Carrier J; Comiskey M; Terhorst C; Kim YI. 2001. Molecular Genetics of Ulcerative Colitis-associated Colon Cancer in the Interleukin 2- and beta(2)-Microglobulin-deficient Mouse. Cancer Res 61(18):6912-7. [PubMed: 11559569]  [MGI Ref ID J:71656]

Solaymani-Mohammadi S; Singer SM. 2011. Host immunity and pathogen strain contribute to intestinal disaccharidase impairment following gut infection. J Immunol 187(7):3769-75. [PubMed: 21873528]  [MGI Ref ID J:179334]

Somigliana E; Vigano P; Filardo P; Candiani M; Vignali M; Panina-Bordignon P. 2001. Use of knockout transgenic mice in the study of endometriosis: insights from mice lacking beta(2)-microglobulin and interleukin-12p40. Fertil Steril 75(1):203-6. [PubMed: 11163839]  [MGI Ref ID J:66996]

Spencer CT; Dragovic SM; Conant SB; Gray JJ; Zheng M; Samir P; Niu X; Moutaftsi M; Van Kaer L; Sette A; Link AJ; Joyce S. 2013. Sculpting MHC class II-restricted self and non-self peptidome by the class I Ag-processing machinery and its impact on Th-cell responses. Eur J Immunol 43(5):1162-72. [PubMed: 23386199]  [MGI Ref ID J:198053]

Spriggs MK; Koller BH; Sato T; Morrissey PJ; Fanslow WC; Smithies O; Voice RF; Widmer MB; Maliszewski CR. 1992. Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses. Proc Natl Acad Sci U S A 89(13):6070-4. [PubMed: 1631092]  [MGI Ref ID J:111183]

Sproule TJ; Jazwinska EC; Britton RS; Bacon BR; Fleming RE; Sly WS; Roopenian DC. 2001. Naturally variant autosomal and sex-linked loci determine the severity of iron overload in beta 2-microglobulin-deficient mice. Proc Natl Acad Sci U S A 98(9):5170-4. [PubMed: 11309500]  [MGI Ref ID J:68985]

Street SE; Hayakawa Y; Zhan Y; Lew AM; MacGregor D; Jamieson AM; Diefenbach A; Yagita H; Godfrey DI; Smyth MJ. 2004. Innate Immune Surveillance of Spontaneous B Cell Lymphomas by Natural Killer Cells and {gamma}{delta} T Cells. J Exp Med 199(6):879-884. [PubMed: 15007091]  [MGI Ref ID J:90480]

Su HC; Cousens LP; Fast LD; Slifka MK; Bungiro RD; Ahmed R; Biron CA. 1998. CD4+ and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections: requirements for IL-2. J Immunol 160(10):5007-17. [PubMed: 9590250]  [MGI Ref ID J:111005]

Su HC; Orange JS; Fast LD; Chan AT; Simpson SJ; Terhorst C; Biron CA. 1994. IL-2-dependent NK cell responses discovered in virus-infected beta 2-microglobulin-deficient mice. J Immunol 153(12):5674-81. [PubMed: 7989765]  [MGI Ref ID J:21901]

Sullivan BA; Kraj P; Weber DA; Ignatowicz L; Jensen PE. 2002. Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin. Immunity 17(1):95-105. [PubMed: 12150895]  [MGI Ref ID J:132383]

Sun JC; Lanier LL. 2008. Cutting edge: viral infection breaks NK cell tolerance to 'missing self'. J Immunol 181(11):7453-7. [PubMed: 19017932]  [MGI Ref ID J:142209]

Sun K; Alvarez M; Ames E; Barao I; Chen M; Longo DL; Redelman D; Murphy WJ. 2012. Mouse NK cell-mediated rejection of bone marrow allografts exhibits patterns consistent with Ly49 subset licensing. Blood 119(6):1590-8. [PubMed: 22184406]  [MGI Ref ID J:181726]

Suzuki H; Punt JA; Granger LG; Singer A. 1995. Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection. Immunity 2(4):413-25. [PubMed: 7719943]  [MGI Ref ID J:189417]

Takaki T; Marron MP; Mathews CE; Guttmann ST; Bottino R; Trucco M; DiLorenzo TP; Serreze DV. 2006. HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. J Immunol 176(5):3257-65. [PubMed: 16493087]  [MGI Ref ID J:121685]

Takeda K; Nakayama M; Sakaki M; Hayakawa Y; Imawari M; Ogasawara K; Okumura K; Smyth MJ. 2011. IFN-gamma production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice. J Leukoc Biol 90(4):777-85. [PubMed: 21712396]  [MGI Ref ID J:177544]

Taki S; Nakajima S; Ichikawa E; Saito T; Hida S. 2005. IFN regulatory factor-2 deficiency revealed a novel checkpoint critical for the generation of peripheral NK cells. J Immunol 174(10):6005-12. [PubMed: 15879093]  [MGI Ref ID J:98991]

Tan JT; Dudl E; LeRoy E; Murray R; Sprent J; Weinberg KI; Surh CD. 2001. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc Natl Acad Sci U S A 98(15):8732-7. [PubMed: 11447288]  [MGI Ref ID J:93058]

Tanaka H; Naito T; Muroi S; Seo W; Chihara R; Miyamoto C; Kominami R; Taniuchi I. 2013. Epigenetic Thpok silencing limits the time window to choose CD4(+) helper-lineage fate in the thymus. EMBO J 32(8):1183-94. [PubMed: 23481257]  [MGI Ref ID J:195348]

Taniguchi RT; Guzior D; Kumar V. 2007. 2B4 inhibits NK-cell fratricide. Blood 110(6):2020-3. [PubMed: 17537992]  [MGI Ref ID J:146407]

Tao W; Sherwood ER. 2004. Beta2-microglobulin knockout mice treated with anti-asialoGM1 exhibit improved hemodynamics and cardiac contractile function during acute intra-abdominal sepsis. Am J Physiol Regul Integr Comp Physiol 286(3):R569-75. [PubMed: 14630624]  [MGI Ref ID J:95749]

Tarakanova VL; Kreisel F; White DW; Virgin HW 4th. 2008. Murine gammaherpesvirus 68 genes both induce and suppress lymphoproliferative disease. J Virol 82(2):1034-9. [PubMed: 17977975]  [MGI Ref ID J:130353]

Tarakanova VL; Suarez F; Tibbetts SA; Jacoby MA; Weck KE; Hess JL; Speck SH; Virgin HW 4th. 2005. Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice. J Virol 79(23):14668-79. [PubMed: 16282467]  [MGI Ref ID J:102883]

Tay CH; Welsh RM; Brutkiewicz RR. 1995. NK cell response to viral infections in beta 2-microglobulin-deficient mice. J Immunol 154(2):780-9. [PubMed: 7529286]  [MGI Ref ID J:22235]

Taylor SF; Cottey RJ; Zander DS; Bender BS. 1997. Influenza infection of beta 2-microglobulin-deficient (beta 2m-/-) mice reveals a loss of CD4+ T cell functions with aging. J Immunol 159(7):3453-9. [PubMed: 9317144]  [MGI Ref ID J:110680]

TeKippe M; Harrison DE; Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp Hematol 31(6):521-7. [PubMed: 12829028]  [MGI Ref ID J:115677]

Teh SJ; Killeen N; Tarakhovsky A; Littman DR; Teh HS. 1997. CD2 regulates the positive selection and function of antigen-specific CD4- CD8+ T cells. Blood 89(4):1308-18. [PubMed: 9028954]  [MGI Ref ID J:111606]

Terabe M; Tagaya Y; Zhu Q; Granger L; Roederer M; Waldmann TA; Berzofsky JA. 2008. IL-15 expands unconventional CD8alphaalphaNK1.1+ T cells but not Valpha14Jalpha18+ NKT cells. J Immunol 180(11):7276-86. [PubMed: 18490727]  [MGI Ref ID J:136310]

Terra R; Labrecque N; Perreault C. 2002. Thymic and extrathymic T cell development pathways follow different rules. J Immunol 169(2):684-92. [PubMed: 12097370]  [MGI Ref ID J:123838]

Thams S; Brodin P; Plantman S; Saxelin R; Karre K; Cullheim S. 2009. Classical major histocompatibility complex class I molecules in motoneurons: new actors at the neuromuscular junction. J Neurosci 29(43):13503-15. [PubMed: 19864563]  [MGI Ref ID J:158310]

Tikhonova AN; Van Laethem F; Hanada K; Lu J; Pobezinsky LA; Hong C; Guinter TI; Jeurling SK; Bernhardt G; Park JH; Yang JC; Sun PD; Singer A. 2012. alphabeta T Cell Receptors that Do Not Undergo Major Histocompatibility Complex-Specific Thymic Selection Possess Antibody-like Recognition Specificities. Immunity 36(1):79-91. [PubMed: 22209676]  [MGI Ref ID J:180750]

Tilloy F; Treiner E; Park SH; Garcia C; Lemonnier F; de la Salle H; Bendelac A; Bonneville M; Lantz O. 1999. An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammals. J Exp Med 189(12):1907-21. [PubMed: 10377186]  [MGI Ref ID J:55844]

Treiner E; Duban L; Bahram S; Radosavljevic M; Wanner V; Tilloy F; Affaticati P; Gilfillan S; Lantz O. 2003. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature 422(6928):164-9. [PubMed: 12634786]  [MGI Ref ID J:113083]

Tripathy SK; Keyel PA; Yang L; Pingel JT; Cheng TP; Schneeberger A; Yokoyama WM. 2008. Continuous engagement of a self-specific activation receptor induces NK cell tolerance. J Exp Med 205(8):1829-41. [PubMed: 18606857]  [MGI Ref ID J:138607]

Tsai S; Serra P; Clemente-Casares X; Slattery RM; Santamaria P. 2013. Dendritic cell-dependent in vivo generation of autoregulatory T cells by antidiabetogenic MHC class II. J Immunol 191(1):70-82. [PubMed: 23740949]  [MGI Ref ID J:205347]

Tsui H; Chan Y; Tang L; Winer S; Cheung RK; Paltser G; Selvanantham T; Elford AR; Ellis JR; Becker DJ; Ohashi PS; Dosch HM. 2008. Targeting of pancreatic glia in type 1 diabetes. Diabetes 57(4):918-28. [PubMed: 18198358]  [MGI Ref ID J:135214]

Tsuji-Kawahara S; Kawabata H; Matsukuma H; Kinoshita S; Chikaishi T; Sakamoto M; Kawasaki Y; Miyazawa M. 2013. Differential requirements of cellular and humoral immune responses for Fv2-associated resistance to erythroleukemia and for regulation of retrovirus-induced myeloid leukemia development. J Virol 87(24):13760-74. [PubMed: 24109240]  [MGI Ref ID J:205215]

Tsumiyama K; Hashiramoto A; Takimoto M; Tsuji-Kawahara S; Miyazawa M; Shiozawa S. 2013. IFN-gamma-producing effector CD8 T lymphocytes cause immune glomerular injury by recognizing antigen presented as immune complex on target tissue. J Immunol 191(1):91-6. [PubMed: 23720810]  [MGI Ref ID J:205371]

Tu MM; Mahmoud AB; Wight A; Mottashed A; Belanger S; Rahim MM; Abou-Samra E; Makrigiannis AP. 2014. Ly49 family receptors are required for cancer immunosurveillance mediated by natural killer cells. Cancer Res 74(14):3684-94. [PubMed: 24802191]  [MGI Ref ID J:212545]

Tyznik AJ; Sun JC; Bevan MJ. 2004. The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells. J Exp Med 199(4):559-65. [PubMed: 14769854]  [MGI Ref ID J:90469]

Tzelepis F; Verway M; Daoud J; Gillard J; Hassani-Ardakani K; Dunn J; Downey J; Gentile ME; Jaworska J; Sanchez AM; Nedelec Y; Vali H; Tabrizian M; Kristof AS; King IL; Barreiro LB; Divangahi M. 2015. Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection. J Clin Invest 125(2):752-68. [PubMed: 25562320]  [MGI Ref ID J:220394]

Ueno A; Cho S; Cheng L; Wang Z; Wang B; Yang Y. 2005. Diabetes resistance/susceptibility in T cells of nonobese diabetic mice conferred by MHC and MHC-linked genes. J Immunol 175(8):5240-7. [PubMed: 16210629]  [MGI Ref ID J:119112]

Ueno T; Saito F; Gray DH; Kuse S; Hieshima K; Nakano H; Kakiuchi T; Lipp M; Boyd RL; Takahama Y. 2004. CCR7 signals are essential for cortex-medulla migration of developing thymocytes. J Exp Med 200(4):493-505. [PubMed: 15302902]  [MGI Ref ID J:93960]

Urdahl KB; Liggitt D; Bevan MJ. 2003. CD8+ T cells accumulate in the lungs of Mycobacterium tuberculosis-infected Kb-/-Db-/- mice, but provide minimal protection. J Immunol 170(4):1987-94. [PubMed: 12574368]  [MGI Ref ID J:82297]

Van Den Broeck T; Stevenaert F; Taveirne S; Debacker V; Vangestel C; Vandekerckhove B; Taghon T; Matthys P; Plum J; Held W; Dewerchin M; Yokoyama WM; Leclercq G. 2008. Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator. Blood 112(13):5046-51. [PubMed: 18784372]  [MGI Ref ID J:143621]

Van Laethem F; Sarafova SD; Park JH; Tai X; Pobezinsky L; Guinter TI; Adoro S; Adams A; Sharrow SO; Feigenbaum L; Singer A. 2007. Deletion of CD4 and CD8 Coreceptors Permits Generation of alphabetaT Cells that Recognize Antigens Independently of the MHC. Immunity 27(5):735-50. [PubMed: 18023370]  [MGI Ref ID J:127623]

Van Laethem F; Tikhonova AN; Pobezinsky LA; Tai X; Kimura MY; Le Saout C; Guinter TI; Adams A; Sharrow SO; Bernhardt G; Feigenbaum L; Singer A. 2013. Lck availability during thymic selection determines the recognition specificity of the T cell repertoire. Cell 154(6):1326-41. [PubMed: 24034254]  [MGI Ref ID J:204615]

Van de Keere F; Tonegawa S. 1998. CD4(+) T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice. J Exp Med 188(10):1875-82. [PubMed: 9815265]  [MGI Ref ID J:115028]

Verykokakis M; Boos MD; Bendelac A; Kee BL. 2010. SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics. Immunity 33(2):203-15. [PubMed: 20674402]  [MGI Ref ID J:163924]

Vesosky B; Rottinghaus EK; Davis C; Turner J. 2009. CD8 T Cells in old mice contribute to the innate immune response to Mycobacterium tuberculosis via interleukin-12p70-dependent and antigen-independent production of gamma interferon. Infect Immun 77(8):3355-63. [PubMed: 19470747]  [MGI Ref ID J:151445]

Vikingsson A; Pederson K; Muller D. 1996. Altered kinetics of CD4+ T cell proliferation and interferon-gamma production in the absence of CD8+ T lymphocytes in virus-infected beta2-microglobulin-deficient mice. Cell Immunol 173(2):261-8. [PubMed: 8912885]  [MGI Ref ID J:36758]

Wang B; Sharma A; Maile R; Saad M; Collins EJ; Frelinger JA. 2002. Peptidic termini play a significant role in TCR recognition. J Immunol 169(6):3137-45. [PubMed: 12218131]  [MGI Ref ID J:120444]

Wang D; Zheng M; Lei L; Ji J; Yao Y; Qiu Y; Ma L; Lou J; Ouyang C; Zhang X; He Y; Chi J; Wang L; Kuang Y; Wang J; Cao X; Lu L. 2012. Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nat Immunol 13(6):560-8. [PubMed: 22561606]  [MGI Ref ID J:186446]

Wei CH; Sherman LA. 2007. N-terminal trimer extension of nominal CD8 T cell epitopes is sufficient to promote cross-presentation to cognate CD8 T cells in vivo. J Immunol 179(12):8280-6. [PubMed: 18056372]  [MGI Ref ID J:155198]

Weidanz WP; Lafleur G; Brown A; Burns JM Jr; Gramaglia I; van der Heyde HC. 2010. {gamma}{delta} T Cells but Not NK Cells Are Essential for Cell-Mediated Immunity against Plasmodium chabaudi Malaria. Infect Immun 78(10):4331-40. [PubMed: 20660608]  [MGI Ref ID J:164250]

Wells FB; Gahm SJ; Hedrick SM; Bluestone JA; Dent A; Matis LA. 1991. Requirement for positive selection of gamma delta receptor-bearing T cells. Science 253(5022):903-5. [PubMed: 1831565]  [MGI Ref ID J:113013]

White AJ; Withers DR; Parnell SM; Scott HS; Finke D; Lane PJ; Jenkinson EJ; Anderson G. 2008. Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input. Eur J Immunol 38(4):942-7. [PubMed: 18350550]  [MGI Ref ID J:133775]

Whitfield-Larry F; Young EF; Talmage G; Fudge E; Azam A; Patel S; Largay J; Byrd W; Buse J; Calikoglu AS; Shultz LD; Frelinger JA. 2011. HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/gammac(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells. Diabetes 60(6):1726-33. [PubMed: 21521873]  [MGI Ref ID J:177952]

Wickstrom SL; Oberg L; Karre K; Johansson MH. 2014. A genetic defect in mice that impairs missing self recognition despite evidence for normal maturation and MHC class I-dependent education of NK cells. J Immunol 192(4):1577-86. [PubMed: 24442431]  [MGI Ref ID J:209366]

Williams DM; Grubbs BG; Pack E; Kelly K; Rank RG. 1997. Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis. Infect Immun 65(7):2876-82. [PubMed: 9199462]  [MGI Ref ID J:41109]

Wilson EB; Parachoniak CA; Carpenito C; Mager DL; Takei F. 2007. Expression of murine killer immunoglobulin-like receptor KIRL1 on CD1d-independent NK1.1(+) T cells. Immunogenetics 59(8):641-51. [PubMed: 17516061]  [MGI Ref ID J:141918]

Winer DA; Winer S; Shen L; Wadia PP; Yantha J; Paltser G; Tsui H; Wu P; Davidson MG; Alonso MN; Leong HX; Glassford A; Caimol M; Kenkel JA; Tedder TF; McLaughlin T; Miklos DB; Dosch HM; Engleman EG. 2011. B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med 17(5):610-7. [PubMed: 21499269]  [MGI Ref ID J:171607]

Wong KL; Lew FC; MacAry PA; Kemeny DM. 2008. CD40L-expressing CD8 T cells prime CD8alpha(+) DC for IL-12p70 production. Eur J Immunol 38(8):2251-62. [PubMed: 18600823]  [MGI Ref ID J:138592]

Wortham BW; Eppert BL; Motz GT; Flury JL; Orozco-Levi M; Hoebe K; Panos RJ; Maxfield M; Glasser SW; Senft AP; Raulet DH; Borchers MT. 2012. NKG2D mediates NK cell hyperresponsiveness and influenza-induced pathologies in a mouse model of chronic obstructive pulmonary disease. J Immunol 188(9):4468-75. [PubMed: 22467655]  [MGI Ref ID J:188448]

Wu X; Wang L; Schroer S; Choi D; Chen P; Okada H; Woo M. 2009. Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice. Diabetologia :. [PubMed: 19644667]  [MGI Ref ID J:151770]

Xu S; Liu X; Bao Y; Zhu X; Han C; Zhang P; Zhang X; Li W; Cao X. 2012. Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway. Nat Immunol 13(6):551-9. [PubMed: 22522491]  [MGI Ref ID J:186456]

Yamazaki C; Sugiyama M; Ohta T; Hemmi H; Hamada E; Sasaki I; Fukuda Y; Yano T; Nobuoka M; Hirashima T; Iizuka A; Sato K; Tanaka T; Hoshino K; Kaisho T. 2013. Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1. J Immunol 190(12):6071-82. [PubMed: 23670193]  [MGI Ref ID J:204851]

Yin CC; Cho OH; Sylvia KE; Narayan K; Prince AL; Evans JW; Kang J; Berg LJ. 2013. The Tec Kinase ITK Regulates Thymic Expansion, Emigration, and Maturation of gammadelta NKT Cells. J Immunol 190(6):2659-69. [PubMed: 23378428]  [MGI Ref ID J:193616]

Yokote H; Miyake S; Croxford JL; Oki S; Mizusawa H; Yamamura T. 2008. NKT cell-dependent amelioration of a mouse model of multiple sclerosis by altering gut flora. Am J Pathol 173(6):1714-23. [PubMed: 18974295]  [MGI Ref ID J:143928]

Young HY; Zucker P; Flavell RA; Jevnikar AM; Singh B. 2004. Characterization of the role of major histocompatibility complex in type 1 diabetes recurrence after islet transplantation. Transplantation 78(4):509-15. [PubMed: 15446308]  [MGI Ref ID J:107051]

Zanoni I; Spreafico R; Bodio C; Di Gioia M; Cigni C; Broggi A; Gorletta T; Caccia M; Chirico G; Sironi L; Collini M; Colombo MP; Garbi N; Granucci F. 2013. IL-15 cis presentation is required for optimal NK cell activation in lipopolysaccharide-mediated inflammatory conditions. Cell Rep 4(6):1235-49. [PubMed: 24055061]  [MGI Ref ID J:203792]

Zavidij O; Ball CR; Herbst F; Fessler S; Schmidt M; von Kalle C; Glimm H. 2010. Hematopoietic activity of human short-term repopulating cells in mobilized peripheral blood cell transplants is restricted to the first 5 months after transplantation. Blood 115(24):5023-5. [PubMed: 20382848]  [MGI Ref ID J:161539]

Zeng D; Gazit G; Dejbakhsh-Jones S; Balk SP; Snapper S; Taniguchi M; Strober S. 1999. Heterogeneity of NK1.1+ T cells in the bone marrow: divergence from the thymus. J Immunol 163(10):5338-45. [PubMed: 10553057]  [MGI Ref ID J:58455]

Zhang B; Kracker S; Yasuda T; Casola S; Vanneman M; Homig-Holzel C; Wang Z; Derudder E; Li S; Chakraborty T; Cotter SE; Koyama S; Currie T; Freeman GJ; Kutok JL; Rodig SJ; Dranoff G; Rajewsky K. 2012. Immune Surveillance and Therapy of Lymphomas Driven by Epstein-Barr Virus Protein LMP1 in a Mouse Model. Cell 148(4):739-51. [PubMed: 22341446]  [MGI Ref ID J:181546]

Zhang JQ; Okumura C; McCarty T; Shin MS; Mukhopadhyay P; Hori M; Torrey TA; Naghashfar Z; Zhou JX; Lee CH; Roopenian DC; Morse HC 3rd; Davidson WF. 2004. Evidence for selective transformation of autoreactive immature plasma cells in mice deficient in Fasl. J Exp Med 200(11):1467-78. [PubMed: 15583018]  [MGI Ref ID J:94696]

Zhang Y; Rogers KH; Lewis DB. 1996. Beta 2-microglobulin-dependent T cells are dispensable for allergen-induced T helper 2 responses. J Exp Med 184(4):1507-12. [PubMed: 8879221]  [MGI Ref ID J:39962]

Zhu X; Peng J; Raychowdhury R; Nakajima A; Lencer WI; Blumberg RS. 2002. The heavy chain of neonatal Fc receptor for IgG is sequestered in endoplasmic reticulum by forming oligomers in the absence of beta2-microglobulin association. Biochem J 367(Pt 3):703-14. [PubMed: 12162790]  [MGI Ref ID J:79983]

Zimmer J; Ioannidis V; Held W. 2001. H-2D ligand expression by Ly49A+ natural killer (NK) cells precludes ligand uptake from environmental cells: implications for NK cell function. J Exp Med 194(10):1531-9. [PubMed: 11714759]  [MGI Ref ID J:108568]

de Goer de Herve MG; Dembele B; Vallee M; Herr F; Cariou A; Taoufik Y. 2010. Direct CD4 help provision following interaction of memory CD4 and CD8 T cells with distinct antigen-presenting dendritic cells. J Immunol 185(2):1028-36. [PubMed: 20562265]  [MGI Ref ID J:162023]

van Meerwijk JP; O'Connell EM; Germain RN. 1995. Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes. J Immunol 154(12):6314-23. [PubMed: 7759870]  [MGI Ref ID J:110813]

Pde6brd1 related

Acosta ML; Fletcher EL; Azizoglu S; Foster LE; Farber DB; Kalloniatis M. 2005. Early markers of retinal degeneration in rd/rd mice. Mol Vis 11:717-28. [PubMed: 16163270]  [MGI Ref ID J:103970]

Aftab U; Jiang C; Tucker B; Kim JY; Klassen H; Miljan E; Sinden J; Young M. 2009. Growth kinetics and transplantation of human retinal progenitor cells. Exp Eye Res 89(3):301-10. [PubMed: 19524569]  [MGI Ref ID J:151412]

Ahuja S; Ahuja-Jensen P; Johnson LE; Caffe AR; Abrahamson M; Ekstrom PA; van Veen T. 2008. rd1 Mouse retina shows an imbalance in the activity of cysteine protease cathepsins and their endogenous inhibitor cystatin C. Invest Ophthalmol Vis Sci 49(3):1089-96. [PubMed: 18326735]  [MGI Ref ID J:133024]

Ahuja-Jensen P; Johnsen-Soriano S; Ahuja S; Bosch-Morell F; Sancho-Tello M; Romero FJ; Abrahamson M; van Veen T. 2007. Low glutathione peroxidase in rd1 mouse retina increases oxidative stress and proteases. Neuroreport 18(8):797-801. [PubMed: 17471069]  [MGI Ref ID J:122802]

Alavi MV; Bette S; Schimpf S; Schuettauf F; Schraermeyer U; Wehrl HF; Ruttiger L; Beck SC; Tonagel F; Pichler BJ; Knipper M; Peters T; Laufs J; Wissinger B. 2007. A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy. Brain 130(Pt 4):1029-42. [PubMed: 17314202]  [MGI Ref ID J:154966]

Allen AE; Brown TM; Lucas RJ. 2011. A distinct contribution of short-wavelength-sensitive cones to light-evoked activity in the mouse pretectal olivary nucleus. J Neurosci 31(46):16833-43. [PubMed: 22090509]  [MGI Ref ID J:177906]

Allen AE; Cameron MA; Brown TM; Vugler AA; Lucas RJ. 2010. Visual responses in mice lacking critical components of all known retinal phototransduction cascades. PLoS One 5(11):e15063. [PubMed: 21124780]  [MGI Ref ID J:167121]

Alvarez-Lopez C; Cernuda-Cernuda R; Alcorta E; Alvarez-Viejo M; Manuel Garcia-Fernandez J. 2004. Altered endogenous activation of CREB in the suprachiasmatic nucleus of mice with retinal degeneration. Brain Res 1024(1-2):137-45. [PubMed: 15451375]  [MGI Ref ID J:92980]

Alvarez-Lopez C; Cernuda-Cernuda R; Garcia-Fernandez JM. 2006. The mPer1 clock gene expression in the rd mouse suprachiasmatic nucleus is affected by the retinal degeneration. Brain Res 1087(1):134-41. [PubMed: 16626665]  [MGI Ref ID J:109668]

Alvarez-Lopez C; Cernuda-Cernuda R; Paniagua MA; Alvarez-Viejo M; Fernandez-Lopez A; Garcia-Fernandez JM. 2004. The transcription factor CREB is phosphorylated in neurons of the piriform cortex of blind mice in response to illumination of the retina. Neurosci Lett 357(3):223-6. [PubMed: 15003290]  [MGI Ref ID J:121036]

Ardayfio P; Moon J; Leung KK; Youn-Hwang D; Kim KS. 2008. Impaired learning and memory in Pitx3 deficient aphakia mice: A genetic model for striatum-dependent cognitive symptoms in Parkinson's disease. Neurobiol Dis :. [PubMed: 18573342]  [MGI Ref ID J:136304]

Ash J; McLeod DS; Lutty GA. 2005. Transgenic expression of leukemia inhibitory factor (LIF) blocks normal vascular development but not pathological neovascularization in the eye. Mol Vis 11:298-308. [PubMed: 15889014]  [MGI Ref ID J:98579]

Ash JA; Velazquez R; Kelley CM; Powers BE; Ginsberg SD; Mufson EJ; Strupp BJ. 2014. Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice. Neurobiol Dis 70:32-42. [PubMed: 24932939]  [MGI Ref ID J:218355]

Audo I; Bujakowska K; Orhan E; Poloschek CM; Defoort-Dhellemmes S; Drumare I; Kohl S; Luu TD; Lecompte O; Zrenner E; Lancelot ME; Antonio A; Germain A; Michiels C; Audier C; Letexier M; Saraiva JP; Leroy BP; Munier FL; Mohand-Said S; Lorenz B; Friedburg C; Preising M; Kellner U; Renner AB; Moskova-Doumanova V; Berger W; Wissinger B; Hamel CP; Schorderet DF; De Baere E; Sharon D; Banin E; Jacobson SG; Bonneau D; Zanlonghi X; Le Meur G; Casteels I; Koenekoop R; Long VW; Meire F; Prescott K; de Ravel T; Simm. 2012. Whole-exome sequencing identifies mutations in GPR179 leading to autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet 90(2):321-30. [PubMed: 22325361]  [MGI Ref ID J:196741]

Azadi S; Paquet-Durand F; Medstrand P; van Veen T; Ekstrom PA. 2006. Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina. Mol Cell Neurosci 31(4):759-73. [PubMed: 16503160]  [MGI Ref ID J:108601]

BRUCKNER R. 1951. [Slit-lamp microscopy and ophthalmoscopy in rat and mouse.] Doc Ophthalmol 5-6:452-554. [PubMed: 14896883]  [MGI Ref ID J:25576]

Ball SL; Powers PA; Shin HS; Morgans CW; Peachey NS; Gregg RG. 2002. Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layer. Invest Ophthalmol Vis Sci 43(5):1595-603. [PubMed: 11980879]  [MGI Ref ID J:80080]

Barabas P; Liu A; Xing W; Chen CK; Tong Z; Watt CB; Jones BW; Bernstein PS; Krizaj D. 2013. Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration. Proc Natl Acad Sci U S A 110(13):5181-6. [PubMed: 23479632]  [MGI Ref ID J:194246]

Barber AC; Hippert C; Duran Y; West EL; Bainbridge JW; Warre-Cornish K; Luhmann UF; Lakowski J; Sowden JC; Ali RR; Pearson RA. 2013. Repair of the degenerate retina by photoreceptor transplantation. Proc Natl Acad Sci U S A 110(1):354-9. [PubMed: 23248312]  [MGI Ref ID J:192521]

Bi A; Cui J; Ma YP; Olshevskaya E; Pu M; Dizhoor AM; Pan ZH. 2006. Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration. Neuron 50(1):23-33. [PubMed: 16600853]  [MGI Ref ID J:122947]

Blanks JC; Bok D. 1977. An autoradiographic analysis of postnatal cell proliferation in the normal and degenerative mouse retina. J Comp Neurol 174(2):317-27. [PubMed: 864040]  [MGI Ref ID J:5812]

Borowska J; Trenholm S; Awatramani GB. 2011. An intrinsic neural oscillator in the degenerating mouse retina. J Neurosci 31(13):5000-12. [PubMed: 21451038]  [MGI Ref ID J:171202]

Bowes C; Danciger M; Kozak CA; Farber DB. 1989. Isolation of a candidate cDNA for the gene causing retinal degeneration in the rd mouse [published erratum appears in Proc Natl Acad Sci U S A 1990 Feb;87(4):1625] Proc Natl Acad Sci U S A 86(24):9722-6. [PubMed: 2481314]  [MGI Ref ID J:10184]

Bowes C; Li T; Danciger M; Baxter LC; Applebury ML; Farber DB. 1990. Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase [see comments] Nature 347(6294):677-80. [PubMed: 1977087]  [MGI Ref ID J:10777]

Bowes C; Li T; Frankel WN; Danciger M; Coffin JM; Applebury ML; Farber DB. 1993. Localization of a retroviral element within the rd gene coding for the beta subunit of cGMP phosphodiesterase. Proc Natl Acad Sci U S A 90(7):2955-9. [PubMed: 8385352]  [MGI Ref ID J:4366]

Bramall AN; Szego MJ; Pacione LR; Chang I; Diez E; D'Orleans-Juste P; Stewart DJ; Hauswirth WW; Yanagisawa M; McInnes RR. 2013. Endothelin-2-mediated protection of mutant photoreceptors in inherited photoreceptor degeneration. PLoS One 8(2):e58023. [PubMed: 23469133]  [MGI Ref ID J:198395]

Brown TM; Gias C; Hatori M; Keding SR; Semo M; Coffey PJ; Gigg J; Piggins HD; Panda S; Lucas RJ. 2010. Melanopsin contributions to irradiance coding in the thalamo-cortical visual system. PLoS Biol 8(12):e1000558. [PubMed: 21151887]  [MGI Ref ID J:170401]

Buhr ED; Van Gelder RN. 2014. Local photic entrainment of the retinal circadian oscillator in the absence of rods, cones, and melanopsin. Proc Natl Acad Sci U S A 111(23):8625-30. [PubMed: 24843129]  [MGI Ref ID J:211359]

Bumsted KM; Rizzolo LJ; Barnstable CJ. 2001. Defects in the MITF(mi/mi) apical surface are associated with a failure of outer segment elongation. Exp Eye Res 73(3):383-92. [PubMed: 11520113]  [MGI Ref ID J:115620]

Busskamp V; Duebel J; Balya D; Fradot M; Viney TJ; Siegert S; Groner AC; Cabuy E; Forster V; Seeliger M; Biel M; Humphries P; Paques M; Mohand-Said S; Trono D; Deisseroth K; Sahel JA; Picaud S; Roska B. 2010. Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science 329(5990):413-7. [PubMed: 20576849]  [MGI Ref ID J:162017]

Caley DW; Johnson C; Liebelt RA. 1972. The postnatal development of the retina in the normal and rodless CBA mouse: a light and electron microscopic study. Am J Anat 133(2):179-212. [PubMed: 5009246]  [MGI Ref ID J:5250]

Cameron MA; Pozdeyev N; Vugler AA; Cooper H; Iuvone PM; Lucas RJ. 2009. Light regulation of retinal dopamine that is independent of melanopsin phototransduction. Eur J Neurosci 29(4):761-7. [PubMed: 19200071]  [MGI Ref ID J:146469]

Carter-Dawson LD; LaVail MM; Sidman RL. 1978. Differential effect of the rd mutation on rods and cones in the mouse retina. Invest Ophthalmol Vis Sci 17(6):489-98. [PubMed: 659071]  [MGI Ref ID J:5988]

Cayouette M; Gravel C. 1997. Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse. Hum Gene Ther 8(4):423-30. [PubMed: 9054517]  [MGI Ref ID J:39262]

Cayouette M; Smith SB; Becerra SP; Gravel C. 1999. Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis 6(6):523-32. [PubMed: 10600408]  [MGI Ref ID J:59343]

Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768]  [MGI Ref ID J:75095]

Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases. Vis Neurosci 22(5):587-93. [PubMed: 16332269]  [MGI Ref ID J:156373]

Chang B; Hurd R; Wang J; Nishina P. 2013. Survey of common eye diseases in laboratory mouse strains. Invest Ophthalmol Vis Sci 54(7):4974-81. [PubMed: 23800770]  [MGI Ref ID J:198916]

Charbel Issa P; Singh MS; Lipinski DM; Chong NV; Delori FC; Barnard AR; MacLaren RE. 2012. Optimization of in vivo confocal autofluorescence imaging of the ocular fundus in mice and its application to models of human retinal degeneration. Invest Ophthalmol Vis Sci 53(2):1066-75. [PubMed: 22169101]  [MGI Ref ID J:191520]

Chen B; Cepko CL. 2009. HDAC4 regulates neuronal survival in normal and diseased retinas. Science 323(5911):256-9. [PubMed: 19131628]  [MGI Ref ID J:143166]

Chen Q; Khoury M; Chen J. 2009. Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice. Proc Natl Acad Sci U S A :. [PubMed: 19966223]  [MGI Ref ID J:155817]

Chua J; Nivison-Smith L; Fletcher EL; Trenholm S; Awatramani GB; Kalloniatis M. 2013. Early remodeling of Muller cells in the rd/rd mouse model of retinal dystrophy. J Comp Neurol 521(11):2439-53. [PubMed: 23348616]  [MGI Ref ID J:200732]

Cohen AI; Blazynski C. 1990. Dopamine and its agonists reduce a light-sensitive pool of cyclic AMP in mouse photoreceptors. Vis Neurosci 4(1):43-52. [PubMed: 1702315]  [MGI Ref ID J:78184]

Cornett A; Sucic JF; Hillsburg D; Cyr L; Johnson C; Polanco A; Figuereo J; Cabine K; Russo N; Sturtevant A; Jarvinen MK. 2011. Altered glial gene expression, density, and architecture in the visual cortex upon retinal degeneration. Brain Res 1422:46-56. [PubMed: 21983206]  [MGI Ref ID J:179028]

Danciger M; Bowes C; Kozak CA; LaVail MM; Farber DB. 1990. Fine mapping of a putative rd cDNA and its co-segregation with rd expression. Invest Ophthalmol Vis Sci 31(8):1427-32. [PubMed: 1974892]  [MGI Ref ID J:10689]

Daniels DM; Stoddart CW; Martin-Iverson MT; Lai CM; Redmond TM; Rakoczy PE. 2003. Entrainment of circadian rhythm to a photoperiod reversal shows retinal dystrophy in RPE65(-/-) mice. Physiol Behav 79(4-5):701-11. [PubMed: 12954412]  [MGI Ref ID J:96439]

Davies VJ; Powell KA; White KE; Yip W; Hogan V; Hollins AJ; Davies JR; Piechota M; Brownstein DG; Moat SJ; Nichols PP; Wride MA; Boulton ME; Votruba M. 2008. A missense mutation in the murine Opa3 gene models human Costeff syndrome. Brain 131(Pt 2):368-80. [PubMed: 18222992]  [MGI Ref ID J:181670]

Davis RJ; Tosi J; Janisch KM; Kasanuki JM; Wang NK; Kong J; Tsui I; Cilluffo M; Woodruff ML; Fain GL; Lin CS; Tsang SH. 2008. Functional rescue of degenerating photoreceptors in mice homozygous for a hypomorphic cGMP phosphodiesterase 6 b allele (Pde6bH620Q). Invest Ophthalmol Vis Sci 49(11):5067-76. [PubMed: 18658088]  [MGI Ref ID J:141984]

Del Rio P; Irmler M; Arango-Gonzalez B; Favor J; Bobe C; Bartsch U; Vecino E; Beckers J; Hauck SM; Ueffing M. 2011. GDNF-induced osteopontin from Muller glial cells promotes photoreceptor survival in the Pde6b(rd1) mouse model of retinal degeneration. Glia 59(5):821-32. [PubMed: 21360756]  [MGI Ref ID J:169746]

Delyfer MN; Forster V; Neveux N; Picaud S; Leveillard T; Sahel JA. 2005. Evidence for glutamate-mediated excitotoxic mechanisms during photoreceptor degeneration in the rd1 mouse retina. Mol Vis 11:688-96. [PubMed: 16163266]  [MGI Ref ID J:103968]

Demos C; Bandyopadhyay M; Rohrer B. 2008. Identification of candidate genes for human retinal degeneration loci using differentially expressed genes from mouse photoreceptor dystrophy models. Mol Vis 14:1639-49. [PubMed: 18776951]  [MGI Ref ID J:140115]

Doonan F; Donovan M; Cotter TG. 2003. Caspase-independent photoreceptor apoptosis in mouse models of retinal degeneration. J Neurosci 23(13):5723-31. [PubMed: 12843276]  [MGI Ref ID J:84389]

Drager UC; Hubel DH. 1978. Studies of visual function and its decay in mice with hereditary retinal degeneration. J Comp Neurol 180(1):85-114. [PubMed: 649791]  [MGI Ref ID J:5980]

Du Y; Davisson MT; Kafadar K; Gardiner K. 2006. A-to-I pre-mRNA editing of the serotonin 2C receptor: comparisons among inbred mouse strains. Gene 382:39-46. [PubMed: 16904273]  [MGI Ref ID J:115050]

Ekstrom P; Sanyal S; Narfstrom K; Chader GJ; van Veen T. 1988. Accumulation of glial fibrillary acidic protein in Muller radial glia during retinal degeneration. Invest Ophthalmol Vis Sci 29(9):1363-71. [PubMed: 3417421]  [MGI Ref ID J:27850]

Feng BS; He SH; Zheng PY; Wu L; Yang PC. 2007. Mast cells play a crucial role in Staphylococcus aureus peptidoglycan-induced diarrhea. Am J Pathol 171(2):537-47. [PubMed: 17600127]  [MGI Ref ID J:123928]

Fletcher RT; Sanyal S; Krishna G; Aguirre G; Chader GJ. 1986. Genetic expression of cyclic GMP phosphodiesterase activity defines abnormal photoreceptor differentiation in neurological mutants of inherited retinal degeneration. J Neurochem 46(4):1240-5. [PubMed: 3005510]  [MGI Ref ID J:12044]

Foster RG; Argamaso S; Coleman S; Colwell CS; Lederman A; Provencio I. 1993. Photoreceptors regulating circadian behavior: a mouse model. J Biol Rhythms 8 Suppl:S17-23. [PubMed: 8274758]  [MGI Ref ID J:17940]

Foster RG; Provencio I; Hudson D; Fiske S; De Grip W; Menaker M. 1991. Circadian photoreception in the retinally degenerate mouse (rd/rd). J Comp Physiol [A] 169(1):39-50. [PubMed: 1941717]  [MGI Ref ID J:83743]

Frasson M; Picaud S; Leveillard T; Simonutti M; Mohand-Said S; Dreyfus H; Hicks D; Sabel J. 1999. Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse. Invest Ophthalmol Vis Sci 40(11):2724-34. [PubMed: 10509671]  [MGI Ref ID J:57866]

Frasson M; Sahel JA; Fabre M; Simonutti M; Dreyfus H; Picaud S. 1999. Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse. Nat Med 5(10):1183-7. [PubMed: 10502823]  [MGI Ref ID J:57986]

Gao H; Hollyfield JG. 1995. Basic fibroblast growth factor in retinal development: differential levels of bFGF expression and content in normal and retinal degeneration (rd) mutant mice. Dev Biol 169(1):168-184. [PubMed: 7750636]  [MGI Ref ID J:25273]

Garcia-Fernandez JM; Jimenez AJ; Foster RG. 1995. The persistence of cone photoreceptors within the dorsal retina of aged retinally degenerate mice (rd/rd): implications for circadian organization. Neurosci Lett 187(1):33-6. [PubMed: 7617296]  [MGI Ref ID J:25157]

Gaub BM; Berry MH; Holt AE; Reiner A; Kienzler MA; Dolgova N; Nikonov S; Aguirre GD; Beltran WA; Flannery JG; Isacoff EY. 2014. Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells. Proc Natl Acad Sci U S A 111(51):E5574-83. [PubMed: 25489083]  [MGI Ref ID J:216941]

Gimenez E; Montoliu L. 2001. A simple polymerase chain reaction assay for genotyping the retinal degeneration mutation (Pdeb(rd1)) in FVB/N-derived transgenic mice. Lab Anim 35(2):153-6. [PubMed: 11315164]  [MGI Ref ID J:69558]

Goel M; Dhingra NK. 2012. Muller glia express rhodopsin in a mouse model of inherited retinal degeneration. Neuroscience 225:152-61. [PubMed: 22967839]  [MGI Ref ID J:192477]

Golub MS; Germann SL; Mercer M; Gordon MN; Morgan DG; Mayer LP; Hoyer PB. 2008. Behavioral consequences of ovarian atrophy and estrogen replacement in the APPswe mouse. Neurobiol Aging 29(10):1512-23. [PubMed: 17451844]  [MGI Ref ID J:140912]

Gouras P; Du J; Kjeldbye H; Kwun R; Lopez R; Zack DJ. 1991. Transplanted photoreceptors identified in dystrophic mouse retina by a transgenic reporter gene. Invest Ophthalmol Vis Sci 32(13):3167-74. [PubMed: 1748547]  [MGI Ref ID J:607]

Gouras P; Du J; Kjeldbye H; Yamamoto S; Zack DJ. 1994. Long-term photoreceptor transplants in dystrophic and normal mouse retina. Invest Ophthalmol Vis Sci 35(8):3145-53. [PubMed: 8045709]  [MGI Ref ID J:20769]

Grafstein B; Murray M; Ingoglia NA. 1972. Protein synthesis and axonal transport in retinal ganglion cells of mice lacking visual receptors. Brain Res 44(1):37-48. [PubMed: 4115728]  [MGI Ref ID J:5292]

Graham DR; Overbeek PA; Ash JD. 2005. Leukemia inhibitory factor blocks expression of crx and nrl transcription factors to inhibit photoreceptor differentiation. Invest Ophthalmol Vis Sci 46(7):2601-10. [PubMed: 15980254]  [MGI Ref ID J:99409]

Greferath U; Goh HC; Chua PY; Astrand E; O'Brien EE; Fletcher EL; Murphy M. 2009. Mapping retinal degeneration and loss-of-function in Rd-FTL mice. Invest Ophthalmol Vis Sci 50(12):5955-64. [PubMed: 19661224]  [MGI Ref ID J:158255]

Grimm C; Wenzel A; Stanescu D; Samardzija M; Hotop S; Groszer M; Naash M; Gassmann M; Reme C. 2004. Constitutive overexpression of human erythropoietin protects the mouse retina against induced but not inherited retinal degeneration. J Neurosci 24(25):5651-8. [PubMed: 15215287]  [MGI Ref ID J:133235]

Hackam AS; Strom R; Liu D; Qian J; Wang C; Otteson D; Gunatilaka T; Farkas RH; Chowers I; Kageyama M; Leveillard T; Sahel JA; Campochiaro PA; Parmigiani G; Zack DJ. 2004. Identification of gene expression changes associated with the progression of retinal degeneration in the rd1 mouse. Invest Ophthalmol Vis Sci 45(9):2929-42. [PubMed: 15326104]  [MGI Ref ID J:92921]

Hafezi F; Abegg M; Grimm C; Wenzel A; Munz K; Sturmer J; Farber DB; Reme CE. 1998. Retinal degeneration in the rd mouse in the absence of c-fos. Invest Ophthalmol Vis Sci 39(12):2239-44. [PubMed: 9804131]  [MGI Ref ID J:112088]

Hanno Y; Nakahira M; Jishage K; Noda T; Yoshihara Y. 2003. Tracking mouse visual pathways with WGA transgene. Eur J Neurosci 18(10):2910-4. [PubMed: 14656342]  [MGI Ref ID J:128266]

Hart AW; McKie L; Morgan JE; Gautier P; West K; Jackson IJ; Cross SH. 2005. Genotype-phenotype correlation of mouse pde6b mutations. Invest Ophthalmol Vis Sci 46(9):3443-50. [PubMed: 16123450]  [MGI Ref ID J:101336]

Hatori M; Le H; Vollmers C; Keding SR; Tanaka N; Schmedt C; Jegla T; Panda S. 2008. Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses. PLoS ONE 3(6):e2451. [PubMed: 18545654]  [MGI Ref ID J:137151]

Hawes NL; Smith RS; Chang B; Davisson M; Heckenlively JR; John SW. 1999. Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes. Mol Vis 5:22. [PubMed: 10493779]  [MGI Ref ID J:59481]

Heckenlively JR; Chang B; Erway LC; Peng C; Hawes NL; Hageman GS; Roderick TH. 1995. Mouse model for Usher syndrome: linkage mapping suggests homology to Usher type I reported at human chromosome 11p15. Proc Natl Acad Sci U S A 92(24):11100-4. [PubMed: 7479945]  [MGI Ref ID J:121993]

Heynen SR; Tanimoto N; Joly S; Seeliger MW; Samardzija M; Grimm C. 2011. Retinal degeneration modulates intracellular localization of CDC42 in photoreceptors. Mol Vis 17:2934-46. [PubMed: 22128240]  [MGI Ref ID J:179662]

Hopp RM; Ransom N; Hilsenbeck SG; Papermaster DS; Windle JJ. 1998. Apoptosis in the murine rd1 retinal degeneration is predominantly p53-independent. Mol Vis 4:5. [PubMed: 9485488]  [MGI Ref ID J:47520]

Horev G; Benjamini Y; Sakov A; Golani I. 2007. Estimating wall guidance and attraction in mouse free locomotor behavior. Genes Brain Behav 6(1):30-41. [PubMed: 17233639]  [MGI Ref ID J:132656]

Hsiao FC; Liao YH; Tsai LL. 2013. Differential effects of retinal degeneration on sleep and wakefulness responses to short light-dark cycles in albino mice. Neuroscience 248C:459-468. [PubMed: 23811394]  [MGI Ref ID J:207054]

Huber G; Beck SC; Grimm C; Sahaboglu-Tekgoz A; Paquet-Durand F; Wenzel A; Humphries P; Redmond TM; Seeliger MW; Fischer MD. 2009. Spectral domain optical coherence tomography in mouse models of retinal degeneration. Invest Ophthalmol Vis Sci 50(12):5888-95. [PubMed: 19661229]  [MGI Ref ID J:158254]

Huerta JJ; Llamosas MM; Cernuda-Cernuda R; Garcia-Fernandez JM. 1997. Fos expression in the retina of rd/rd mice during the light/dark cycle. Neurosci Lett 232(3):143-6. [PubMed: 9310300]  [MGI Ref ID J:43873]

Huerta JJ; Llamosas MM; Cernuda-Cernuda R; Garcia-Fernandez JM. 1999. Spatio-temporal analysis of light-induced Fos expression in the retina of rd mutant mice. Brain Res 834(1-2):122-7. [PubMed: 10407100]  [MGI Ref ID J:56973]

Hughes S; Pothecary CA; Jagannath A; Foster RG; Hankins MW; Peirson SN. 2012. Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception. Eur J Neurosci 35(1):34-43. [PubMed: 22211741]  [MGI Ref ID J:184336]

Hussain AA; Willmott NJ; Voaden MJ. 1992. Cyclic GMP, calcium and photoreceptor sensitivity in mice heterozygous for the rod dysplasia gene designated rd. Vision Res 32(1):29-36. [PubMed: 1323896]  [MGI Ref ID J:611]

Hwang DY; Fleming SM; Ardayfio P; Moran-Gates T; Kim H; Tarazi FI; Chesselet MF; Kim KS. 2005. 3,4-dihydroxyphenylalanine reverses the motor deficits in Pitx3-deficient aphakia mice: behavioral characterization of a novel genetic model of Parkinson's disease. J Neurosci 25(8):2132-7. [PubMed: 15728853]  [MGI Ref ID J:98209]

Ionita MA; Pittler SJ. 2007. Focus on molecules: rod cGMP phosphodiesterase type 6. Exp Eye Res 84(1):1-2. [PubMed: 16563379]  [MGI Ref ID J:123170]

Jia L; Oh EC; Ng L; Srinivas M; Brooks M; Swaroop A; Forrest D. 2009. Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development. Proc Natl Acad Sci U S A 106(41):17534-9. [PubMed: 19805139]  [MGI Ref ID J:153683]

Johnson LE; van Veen T; Ekstrom PA. 2005. Differential Akt activation in the photoreceptors of normal and rd1 mice. Cell Tissue Res 320(2):213-22. [PubMed: 15789220]  [MGI Ref ID J:105103]

Jomary C; Cullen J; Jones SE. 2006. Inactivation of the Akt survival pathway during photoreceptor apoptosis in the retinal degeneration mouse. Invest Ophthalmol Vis Sci 47(4):1620-9. [PubMed: 16565401]  [MGI Ref ID J:108445]

Jomary C; Thomas M; Grist J; Milbrandt J; Neal MJ; Jones SE. 1999. Expression patterns of neurturin and its receptor components in developing and degenerative mouse retina. Invest Ophthalmol Vis Sci 40(3):568-74. [PubMed: 10067959]  [MGI Ref ID J:53298]

Jones BW; Watt CB; Frederick JM; Baehr W; Chen CK; Levine EM; Milam AH; Lavail MM; Marc RE. 2003. Retinal remodeling triggered by photoreceptor degenerations. J Comp Neurol 464(1):1-16. [PubMed: 12866125]  [MGI Ref ID J:84675]

Jones SE; Jomary C; Grist J; Stewart HJ; Neal MJ. 2000. Identification by array screening of altered nm23-M2/PuF mRNA expression in mouse retinal degeneration. Mol Cell Biol Res Commun 4(1):20-5. [PubMed: 11152623]  [MGI Ref ID J:66982]

Jones SE; Jomary C; Grist J; Thomas MR; Neal MJ. 1998. Expression of Pax-6 mRNA in the retinal degeneration (rd) mouse. Biochem Biophys Res Commun 252(1):236-40. [PubMed: 9813176]  [MGI Ref ID J:50978]

Jones SE; Jomary C; Grist J; Thomas MR; Neal MJ. 1998. Expression of alphaB-crystallin in a mouse model of inherited retinal degeneration. Neuroreport 9(18):4161-5. [PubMed: 9926867]  [MGI Ref ID J:52955]

Joseph RM; Li T. 1996. Overexpression of Bcl-2 or Bcl-XL transgenes and photoreceptor degeneration. Invest Ophthalmol Vis Sci 37(12):2434-46. [PubMed: 8933760]  [MGI Ref ID J:37285]

Kahle M; Horsch M; Fridrich B; Seelig A; Schultheiss J; Leonhardt J; Irmler M; Beckers J; Rathkolb B; Wolf E; Franke N; Gailus-Durner V; Fuchs H; de Angelis MH; Neschen S. 2013. Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis. Mol Metab 2(4):435-46. [PubMed: 24327959]  [MGI Ref ID J:220415]

Kanan Y; Hoffhines A; Rauhauser A; Murray A; Al-Ubaidi MR. 2009. Protein tyrosine-O-sulfation in the retina. Exp Eye Res 89(4):559-67. [PubMed: 19523945]  [MGI Ref ID J:154498]

Kaneko H; Nishiguchi KM; Nakamura M; Kachi S; Terasaki H. 2008. Retardation of photoreceptor degeneration in the detached retina of rd1 mouse. Invest Ophthalmol Vis Sci 49(2):781-7. [PubMed: 18235028]  [MGI Ref ID J:132586]

Karasawa K; Tanaka A; Jung K; Matsuda A; Okamoto N; Oida K; Ebihara N; Ohmori K; Matsuda H. 2011. Retinal degeneration and rd1 mutation in NC/Tnd mice-a human atopic dermatitis model. Curr Eye Res 36(4):350-7. [PubMed: 21275519]  [MGI Ref ID J:179794]

Katti C; Butler R; Sekaran S. 2013. Diurnal and circadian regulation of connexin 36 transcript and protein in the mammalian retina. Invest Ophthalmol Vis Sci 54(1):821-9. [PubMed: 23307963]  [MGI Ref ID J:214563]

Keady BT; Le YZ; Pazour GJ. 2011. IFT20 is required for opsin trafficking and photoreceptor outer segment development. Mol Biol Cell 22(7):921-30. [PubMed: 21307337]  [MGI Ref ID J:183002]

Keeler C. 1966. Retinal degeneration in the mouse is rodless retina. J Hered 57(2):47-50. [PubMed: 5916892]  [MGI Ref ID J:5007]

Keeler CE. 1926. On the Occurrence in the House Mouse of Mendelizing Structural Defect of the Retina Producing Blindness. Proc Natl Acad Sci U S A 12(4):255-8. [PubMed: 16576989]  [MGI Ref ID J:153354]

Keeler CE. 1924. The inheritance of a retinal abnormality in white mice Proc Natl Acad Sci U S A 10(7):329-33. [PubMed: 16576828]  [MGI Ref ID J:24999]

Keeler CE; Sutcliffe E; Chaffee EL. 1928. Normal and 'Rodless' Retinae of the House Mouse with Respect to the Electromotive Force Generated through Stimulation by Light. Proc Natl Acad Sci U S A 14(6):477-84. [PubMed: 16577134]  [MGI Ref ID J:153353]

Kida E; Rabe A; Walus M; Albertini G; Golabek AA. 2013. Long-term running alleviates some behavioral and molecular abnormalities in Down syndrome mouse model Ts65Dn. Exp Neurol 240:178-89. [PubMed: 23201095]  [MGI Ref ID J:196979]

Kirschman LT; Kolandaivelu S; Frederick JM; Dang L; Goldberg AF; Baehr W; Ramamurthy V. 2010. The Leber congenital amaurosis protein, AIPL1, is needed for the viability and functioning of cone photoreceptor cells. Hum Mol Genet 19(6):1076-87. [PubMed: 20042464]  [MGI Ref ID J:157652]

Klein SL; Kriegsfeld LJ; Hairston JE; Rau V; Nelson RJ; Yarowsky PJ. 1996. Characterization of sensorimotor performance, reproductive and aggressive behaviors in segmental trisomic 16 (Ts65Dn) mice. Physiol Behav 60(4):1159-64. [PubMed: 8884947]  [MGI Ref ID J:174274]

Kokkinopoulos I; Pearson RA; Macneil A; Dhomen NS; Maclaren RE; Ali RR; Sowden JC. 2008. Isolation and characterisation of neural progenitor cells from the adult Chx10(orJ/orJ) central neural retina. Mol Cell Neurosci 38(3):359-73. [PubMed: 18514541]  [MGI Ref ID J:137047]

Kolandaivelu S; Chang B; Ramamurthy V. 2011. Rod Phosphodiesterase-6 (PDE6) Catalytic Subunits Restore Cone Function in a Mouse Model Lacking Cone PDE6 Catalytic Subunit. J Biol Chem 286(38):33252-9. [PubMed: 21799013]  [MGI Ref ID J:176734]

Kolandaivelu S; Huang J; Hurley JB; Ramamurthy V. 2009. AIPL1, a protein associated with childhood blindness, interacts with alpha-subunit of rod phosphodiesterase (PDE6) and is essential for its proper assembly. J Biol Chem 284(45):30853-61. [PubMed: 19758987]  [MGI Ref ID J:156330]

Komeima K; Rogers BS; Lu L; Campochiaro PA. 2006. Antioxidants reduce cone cell death in a model of retinitis pigmentosa. Proc Natl Acad Sci U S A 103(30):11300-5. [PubMed: 16849425]  [MGI Ref ID J:111826]

Komeima K; Usui S; Shen J; Rogers BS; Campochiaro PA. 2008. Blockade of neuronal nitric oxide synthase reduces cone cell death in a model of retinitis pigmentosa. Free Radic Biol Med 45(6):905-12. [PubMed: 18634866]  [MGI Ref ID J:142007]

Kranz K; Paquet-Durand F; Weiler R; Janssen-Bienhold U; Dedek K. 2013. Testing for a gap junction-mediated bystander effect in retinitis pigmentosa: secondary cone death is not altered by deletion of connexin36 from cones. PLoS One 8(2):e57163. [PubMed: 23468924]  [MGI Ref ID J:199394]

Kucharska J; Del Rio P; Arango-Gonzalez B; Gorza M; Feuchtinger A; Hauck SM; Ueffing M. 2014. Cyr61 activates retinal cells and prolongs photoreceptor survival in rd1 mouse model of retinitis pigmentosa. J Neurochem 130(2):227-40. [PubMed: 24593181]  [MGI Ref ID J:213667]

Kuenzi F; Rosahl TW; Morton RA; Fitzjohn SM; Collingridge GL; Seabrook GR. 2003. Hippocampal synaptic plasticity in mice carrying the rd mutation in the gene encoding cGMP phosphodiesterase type 6 (PDE6). Brain Res 967(1-2):144-51. [PubMed: 12650975]  [MGI Ref ID J:82830]

LaVail MM; Matthes MT; Yasumura D; Steinberg RH. 1997. Variability in rate of cone degeneration in the retinal degeneration (rd/rd) mouse. Exp Eye Res 65(1):45-50. [PubMed: 9237863]  [MGI Ref ID J:42223]

LaVail MM; Mullen RJ. 1976. Role of the pigment epithelium in inherited retinal degeneration analyzed with experimental mouse chimeras. Exp Eye Res 23(2):227-45. [PubMed: 976367]  [MGI Ref ID J:5708]

LaVail MW; Yasumura D; Matthes MT; Lau-Villacorta C; Unoki K; Sung CH; Steinberg RH. 1998. Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest Ophthalmol Vis Sci 39(3):592-602. [PubMed: 9501871]  [MGI Ref ID J:46230]

Lahdenranta J; Pasqualini R; Schlingemann RO; Hagedorn M; Stallcup WB; Bucana CD; Sidman RL; Arap W. 2001. An anti-angiogenic state in mice and humans with retinal photoreceptor cell degeneration. Proc Natl Acad Sci U S A 98(18):10368-73. [PubMed: 11526242]  [MGI Ref ID J:126744]

Langmann T; Di Gioia SA; Rau I; Stohr H; Maksimovic NS; Corbo JC; Renner AB; Zrenner E; Kumaramanickavel G; Karlstetter M; Arsenijevic Y; Weber BH; Gal A; Rivolta C. 2010. Nonsense mutations in FAM161A cause RP28-associated recessive retinitis pigmentosa. Am J Hum Genet 87(3):376-81. [PubMed: 20705278]  [MGI Ref ID J:169189]

Lavail MM; Nishikawa S; Duncan JL; Yang H; Matthes MT; Yasumura D; Vollrath D; Overbeek PA; Ash JD; Robinson ML. 2008. Sustained delivery of NT-3 from lens fiber cells in transgenic mice reveals specificity of neuroprotection in retinal degenerations. J Comp Neurol 511(6):724-35. [PubMed: 18925574]  [MGI Ref ID J:176641]

Lin B; Koizumi A; Tanaka N; Panda S; Masland RH. 2008. Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin. Proc Natl Acad Sci U S A 105(41):16009-14. [PubMed: 18836071]  [MGI Ref ID J:141434]

Lin B; Masland RH; Strettoi E. 2009. Remodeling of cone photoreceptor cells after rod degeneration in rd mice. Exp Eye Res 88(3):589-99. [PubMed: 19087876]  [MGI Ref ID J:146569]

Lin B; Peng EB. 2013. Retinal ganglion cells are resistant to photoreceptor loss in retinal degeneration. PLoS One 8(6):e68084. [PubMed: 23840814]  [MGI Ref ID J:204325]

Liu SH; Gottsch JD; Vinores SA; Derevjanik NL; McLeod DS; Lutty GA. 2001. EMAP cytokine expression in developing retinas of normal and retinal degeneration (rd) mutant mice. J Neuroimmunol 114(1-2):28-34. [PubMed: 11240012]  [MGI Ref ID J:102963]

Lohr HR; Kuntchithapautham K; Sharma AK; Rohrer B. 2006. Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death. Exp Eye Res 83(2):380-9. [PubMed: 16626700]  [MGI Ref ID J:116326]

Louros SR; Hooks BM; Litvina L; Carvalho AL; Chen C. 2014. A role for stargazin in experience-dependent plasticity. Cell Rep 7(5):1614-25. [PubMed: 24882000]  [MGI Ref ID J:211786]

Lu B; Coffey P; Lund R. 2004. Increased c-fos-like immunoreactivity in the superior colliculus and lateral geniculate nucleus of the rd mouse. Brain Res 1025(1-2):220-5. [PubMed: 15464763]  [MGI Ref ID J:107774]

Lucas RJ; Freedman MS; Munoz M; Garcia-Fernandez JM; Foster RG. 1999. Regulation of the mammalian pineal by non-rod, non-cone, ocular photoreceptors. Science 284(5413):505-7. [PubMed: 10205062]  [MGI Ref ID J:128478]

Lupi D; Oster H; Thompson S; Foster RG. 2008. The acute light-induction of sleep is mediated by OPN4-based photoreception. Nat Neurosci :. [PubMed: 18711396]  [MGI Ref ID J:141041]

Lupi D; Semo M; Foster RG. 2012. Impact of age and retinal degeneration on the light input to circadian brain structures. Neurobiol Aging 33(2):383-92. [PubMed: 20409612]  [MGI Ref ID J:188243]

Marc RE; Jones BW; Anderson JR; Kinard K; Marshak DW; Wilson JH; Wensel T; Lucas RJ. 2007. Neural reprogramming in retinal degeneration. Invest Ophthalmol Vis Sci 48(7):3364-71. [PubMed: 17591910]  [MGI Ref ID J:123271]

Margolis DJ; Gartland AJ; Singer JH; Detwiler PB. 2014. Network oscillations drive correlated spiking of ON and OFF ganglion cells in the rd1 mouse model of retinal degeneration. PLoS One 9(1):e86253. [PubMed: 24489706]  [MGI Ref ID J:212697]

Masana MI; Sumaya IC; Becker-Andre M; Dubocovich ML. 2007. Behavioral characterization and modulation of circadian rhythms by light and melatonin in C3H/HeN mice homozygous for the RORbeta knockout. Am J Physiol Regul Integr Comp Physiol 292(6):R2357-67. [PubMed: 17303680]  [MGI Ref ID J:121989]

Matynia A; Parikh S; Chen B; Kim P; McNeill DS; Nusinowitz S; Evans C; Gorin MB. 2012. Intrinsically photosensitive retinal ganglion cells are the primary but not exclusive circuit for light aversion. Exp Eye Res 105:60-9. [PubMed: 23078956]  [MGI Ref ID J:203664]

May A; Nimtschke U; May CA. 2009. The architecture of the mouse ciliary processes and their changes during retinal degeneration. Exp Eye Res 88(3):561-5. [PubMed: 19059237]  [MGI Ref ID J:146578]

May CA. 2009. Fibrae medullares in the retina of the RD mouse: a case report. Curr Eye Res 34(5):411-3. [PubMed: 19401885]  [MGI Ref ID J:149565]

McFadyen MP; Kusek G; Bolivar VJ; Flaherty L. 2003. Differences among eight inbred strains of mice in motor ability and motor learning on a rotorod. Genes Brain Behav 2(4):214-9. [PubMed: 12953787]  [MGI Ref ID J:104873]

McKenzie JA; Fruttiger M; Abraham S; Lange CA; Stone J; Gandhi P; Wang X; Bainbridge J; Moss SE; Greenwood J. 2012. Apelin is required for non-neovascular remodeling in the retina. Am J Pathol 180(1):399-409. [PubMed: 22067912]  [MGI Ref ID J:180164]

Meng R; Wu J; Harper DC; Wang Y; Kowalska MA; Abrams CS; Brass LF; Poncz M; Stalker TJ; Marks MS. 2015. Defective release of alpha granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models. Blood 125(10):1623-32. [PubMed: 25477496]  [MGI Ref ID J:221384]

Menu dit Huart L; Lorentz O; Goureau O; Leveillard T; Sahel JA. 2004. DNA repair in the degenerating mouse retina. Mol Cell Neurosci 26(3):441-9. [PubMed: 15234348]  [MGI Ref ID J:109747]

Menzler J; Channappa L; Zeck G. 2014. Rhythmic ganglion cell activity in bleached and blind adult mouse retinas. PLoS One 9(8):e106047. [PubMed: 25153888]  [MGI Ref ID J:219242]

Menzler J; Zeck G. 2011. Network oscillations in rod-degenerated mouse retinas. J Neurosci 31(6):2280-91. [PubMed: 21307264]  [MGI Ref ID J:169452]

Mitton KP; Guzman AE; Deshpande M; Byrd D; DeLooff C; Mkoyan K; Zlojutro P; Wallace A; Metcalf B; Laux K; Sotzen J; Tran T. 2014. Different effects of valproic acid on photoreceptor loss in Rd1 and Rd10 retinal degeneration mice. Mol Vis 20:1527-44. [PubMed: 25489226]  [MGI Ref ID J:220255]

Mohand-Said S; Deudon-Combe A; Hicks D; Simonutti M; Forster V ; Fintz AC ; Leveillard T ; Dreyfus H ; Sahel JA. 1998. Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse. Proc Natl Acad Sci U S A 95(14):8357-62. [PubMed: 9653191]  [MGI Ref ID J:48731]

Montana CL; Kolesnikov AV; Shen SQ; Myers CA; Kefalov VJ; Corbo JC. 2013. Reprogramming of adult rod photoreceptors prevents retinal degeneration. Proc Natl Acad Sci U S A 110(5):1732-7. [PubMed: 23319618]  [MGI Ref ID J:193697]

Morin LP; Studholme KM. 2011. Separation of function for classical and ganglion cell photoreceptors with respect to circadian rhythm entrainment and induction of photosomnolence. Neuroscience 199:213-24. [PubMed: 21985934]  [MGI Ref ID J:184037]

Mrosovsky N; Foster RG; Salmon PA. 1999. Thresholds for masking responses to light in three strains of retinally degenerate mice. J Comp Physiol [A] 184(4):423-8. [PubMed: 10377976]  [MGI Ref ID J:56471]

Mrosovsky N; Hampton RR. 1997. Spatial responses to light in mice with severe retinal degeneration. Neurosci Lett 222(3):204-6. [PubMed: 9148250]  [MGI Ref ID J:40689]

Nakamura K; Harada C; Okumura A; Namekata K; Mitamura Y; Yoshida K; Ohno S; Yoshida H; Harada T. 2005. Effect of p75NTR on the regulation of photoreceptor apoptosis in the rd mouse. Mol Vis 11:1229-35. [PubMed: 16402023]  [MGI Ref ID J:136765]

Namekata K; Okumura A; Harada C; Nakamura K; Yoshida H; Harada T. 2006. Effect of photoreceptor degeneration on RNA splicing and expression of AMPA receptors. Mol Vis 12:1586-93. [PubMed: 17200657]  [MGI Ref ID J:117332]

Nishiguchi KM; Nakamura M; Kaneko H; Kachi S; Terasaki H. 2007. The role of VEGF and VEGFR2/Flk1 in proliferation of retinal progenitor cells in murine retinal degeneration. Invest Ophthalmol Vis Sci 48(9):4315-20. [PubMed: 17724222]  [MGI Ref ID J:126933]

Nishikawa S; LaVail MM. 1998. Neovascularization of the RPE: temporal differences in mice with rod photoreceptor gene defects. Exp Eye Res 67(5):509-15. [PubMed: 9878212]  [MGI Ref ID J:52112]

Nuhn JS; Fuerst PG. 2014. Developmental localization of adhesion and scaffolding proteins at the cone synapse. Gene Expr Patterns 16(1):36-50. [PubMed: 25176525]  [MGI Ref ID J:216508]

O'Leary TP; Brown RE. 2009. Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease. Behav Brain Res 201(1):120-7. [PubMed: 19428625]  [MGI Ref ID J:148386]

Ogilvie JM; Hakenewerth AM; Gardner RR; Martak JG; Maggio VM. 2009. Dopamine receptor loss of function is not protective of rd1 rod photoreceptors in vivo. Mol Vis 15:2868-78. [PubMed: 20038975]  [MGI Ref ID J:157088]

Otani A; Kojima H; Guo C; Oishi A; Yoshimura N. 2012. Low-dose-rate, low-dose irradiation delays neurodegeneration in a model of retinitis pigmentosa. Am J Pathol 180(1):328-36. [PubMed: 22074737]  [MGI Ref ID J:180155]

Owens L; Buhr E; Tu DC; Lamprecht TL; Lee J; Van Gelder RN. 2012. Effect of circadian clock gene mutations on nonvisual photoreception in the mouse. Invest Ophthalmol Vis Sci 53(1):454-60. [PubMed: 22159024]  [MGI Ref ID J:191526]

Panda S; Provencio I; Tu DC; Pires SS; Rollag MD; Castrucci AM; Pletcher MT; Sato TK; Wiltshire T; Andahazy M; Kay SA; Van Gelder RN; Hogenesch JB. 2003. Melanopsin is required for non-image-forming photic responses in blind mice. Science 301(5632):525-7. [PubMed: 12829787]  [MGI Ref ID J:165769]

Panda S; Sato TK; Castrucci AM; Rollag MD; DeGrip WJ; Hogenesch JB; Provencio I; Kay SA. 2002. Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting. Science 298(5601):2213-6. [PubMed: 12481141]  [MGI Ref ID J:81501]

Pang J; Cheng M; Haire SE; Barker E; Planelles V; Blanks JC. 2006. Efficiency of lentiviral transduction during development in normal and rd mice. Mol Vis 12:756-67. [PubMed: 16862069]  [MGI Ref ID J:111621]

Paper W; Kroeber M; Heersink S; Stephan DA; Fuchshofer R; Russell P; Tamm ER. 2008. Elevated amounts of myocilin in the aqueous humor of transgenic mice cause significant changes in ocular gene expression. Exp Eye Res 87(3):257-67. [PubMed: 18602390]  [MGI Ref ID J:141881]

Paquet-Durand F ; Hauck SM ; van Veen T ; Ueffing M ; Ekstrom P. 2009. PKG activity causes photoreceptor cell death in two retinitis pigmentosa models. J Neurochem 108(3):796-810. [PubMed: 19187097]  [MGI Ref ID J:146653]

Paquet-Durand F; Azadi S; Hauck SM; Ueffing M; van Veen T; Ekstrom P. 2006. Calpain is activated in degenerating photoreceptors in the rd1 mouse. J Neurochem 96(3):802-14. [PubMed: 16405498]  [MGI Ref ID J:106017]

Paquet-Durand F; Beck S; Michalakis S; Goldmann T; Huber G; Muhlfriedel R; Trifunovic D; Fischer MD; Fahl E; Duetsch G; Becirovic E; Wolfrum U; van Veen T; Biel M; Tanimoto N; Seeliger MW. 2011. A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa. Hum Mol Genet 20(5):941-7. [PubMed: 21149284]  [MGI Ref ID J:169039]

Park H; Tan CC; Faulkner A; Jabbar SB; Schmid G; Abey J; Iuvone PM; Pardue MT. 2013. Retinal degeneration increases susceptibility to myopia in mice. Mol Vis 19:2068-79. [PubMed: 24146540]  [MGI Ref ID J:205341]

Park SJ; Lee DS; Lim EJ; Choi SH; Kang WS; Kim IB; Chun MH. 2008. The absence of the clathrin-dependent endocytosis in rod bipolar cells of the FVB/N mouse retina. Neurosci Lett 439(2):165-9. [PubMed: 18514403]  [MGI Ref ID J:137049]

Peirson SN; Oster H; Jones SL; Leitges M; Hankins MW; Foster RG. 2007. Microarray analysis and functional genomics identify novel components of melanopsin signaling. Curr Biol 17(16):1363-72. [PubMed: 17702581]  [MGI Ref ID J:128396]

Peng GH; Chen S. 2007. Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation. Hum Mol Genet 16(20):3433-52. [PubMed: 17656371]  [MGI Ref ID J:129889]

Pennesi ME; Michaels KV; Magee SS; Maricle A; Davin SP; Garg AK; Gale MJ; Tu DC; Wen Y; Erker LR; Francis PJ. 2012. Long-term characterization of retinal degeneration in rd1 and rd10 mice using spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci 53(8):4644-56. [PubMed: 22562504]  [MGI Ref ID J:213983]

Petrasch-Parwez E; Habbes HW; Weickert S; Lobbecke-Schumacher M; Striedinger K; Wieczorek S; Dermietzel R; Epplen JT. 2004. Fine-structural analysis and connexin expression in the retina of a transgenic model of Huntington's disease. J Comp Neurol 479(2):181-97. [PubMed: 15452853]  [MGI Ref ID J:135880]

Phelan JK; Bok D. 2000. Analysis and quantitation of mRNAs encoding the alpha- and beta-subunits of rod photoreceptor cGMP phosphodiesterase in neonatal retinal degeneration (rd) mouse retinas. Exp Eye Res 71(2):119-28. [PubMed: 10930317]  [MGI Ref ID J:63861]

Pickard GE; Baver SB; Ogilvie MD; Sollars PJ. 2009. Light-induced fos expression in intrinsically photosensitive retinal ganglion cells in melanopsin knockout (opn4) mice. PLoS ONE 4(3):e4984. [PubMed: 19319185]  [MGI Ref ID J:147460]

Pittler SJ; Baehr W. 1991. Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase beta-subunit gene of the rd mouse. Proc Natl Acad Sci U S A 88(19):8322-6. [PubMed: 1656438]  [MGI Ref ID J:11513]

Pittler SJ; Keeler CE; Sidman RL; Baehr W. 1993. PCR analysis of DNA from 70-year-old sections of rodless retina demonstrates identity with the mouse rd defect. Proc Natl Acad Sci U S A 90(20):9616-9. [PubMed: 8415750]  [MGI Ref ID J:15231]

Popper P; Farber DB; Micevych PE; Minoofar K; Bronstein JM. 1997. TRPM-2 expression and tunel staining in neurodegenerative diseases: studies in wobbler and rd mice. Exp Neurol 143(2):246-54. [PubMed: 9056387]  [MGI Ref ID J:38831]

Portera-Cailliau C; Sung CH; Nathans J; Adler R. 1994. Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa. Proc Natl Acad Sci U S A 91(3):974-8. [PubMed: 8302876]  [MGI Ref ID J:16708]

Provencio I; Cooper HM; Foster RG. 1998. Retinal projections in mice with inherited retinal degeneration: implications for circadian photoentrainment. J Comp Neurol 395(4):417-39. [PubMed: 9619497]  [MGI Ref ID J:47756]

Provencio I; Foster RG. 1995. Circadian rhythms in mice can be regulated by photoreceptors with cone-like characteristics. Brain Res 694(1-2):183-90. [PubMed: 8974643]  [MGI Ref ID J:29236]

Provencio I; Wong S; Lederman AB; Argamaso SM; Foster RG. 1994. Visual and circadian responses to light in aged retinally degenerate mice. Vision Res 34(14):1799-806. [PubMed: 7941382]  [MGI Ref ID J:19843]

Punzo C; Cepko C. 2007. Cellular responses to photoreceptor death in the rd1 mouse model of retinal degeneration. Invest Ophthalmol Vis Sci 48(2):849-57. [PubMed: 17251487]  [MGI Ref ID J:123282]

Punzo C; Kornacker K; Cepko CL. 2009. Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa. Nat Neurosci 12(1):44-52. [PubMed: 19060896]  [MGI Ref ID J:144720]

Qiao X; Pennesi M; Seong E; Gao H; Burmeister M; Wu SM. 2003. Photoreceptor degeneration and rd1 mutation in the grizzled/mocha mouse strain. Vision Res 43(8):859-65. [PubMed: 12668055]  [MGI Ref ID J:88031]

RIKEN BioResource Center/RIKEN Genomic Sciences Center. 2008. A Large Scale Mutagenesis Program in RIKEN GSC PhenoSITE, World Wide Web (URL: :.  [MGI Ref ID J:133634]

Rao A; Dallman R; Henderson S; Chen CK. 2007. Gbeta5 is required for normal light responses and morphology of retinal ON-bipolar cells. J Neurosci 27(51):14199-204. [PubMed: 18094259]  [MGI Ref ID J:129267]

Read DS; McCall MA; Gregg RG. 2002. Absence of voltage-dependent calcium channels delays photoreceptor degeneration in rd mice. Exp Eye Res 75(4):415-20. [PubMed: 12387789]  [MGI Ref ID J:79923]

Rich KA; Zhan Y; Blanks JC. 1997. Migration and synaptogenesis of cone photoreceptors in the developing mouse retina. J Comp Neurol 388(1):47-63. [PubMed: 9364238]  [MGI Ref ID J:44100]

Roesch K; Stadler MB; Cepko CL. 2012. Gene expression changes within Muller glial cells in retinitis pigmentosa. Mol Vis 18:1197-214. [PubMed: 22665967]  [MGI Ref ID J:191614]

Rohrer B; Demos C; Frigg R; Grimm C. 2007. Classical complement activation and acquired immune response pathways are not essential for retinal degeneration in the rd1 mouse. Exp Eye Res 84(1):82-91. [PubMed: 17069800]  [MGI Ref ID J:123183]

Rossi C; Strettoi E; Galli-Resta L. 2003. The spatial order of horizontal cells is not affected by massive alterations in the organization of other retinal cells. J Neurosci 23(30):9924-8. [PubMed: 14586022]  [MGI Ref ID J:120041]

Ruan GX; Allen GC; Yamazaki S; McMahon DG. 2008. An autonomous circadian clock in the inner mouse retina regulated by dopamine and GABA. PLoS Biol 6(10):e249. [PubMed: 18959477]  [MGI Ref ID J:141081]

Ruggiero L; Allen CN; Lane Brown R; Robinson DW. 2009. The development of melanopsin-containing retinal ganglion cells in mice with early retinal degeneration. Eur J Neurosci 29(2):359-67. [PubMed: 19200239]  [MGI Ref ID J:146465]

Ryu SB; Ye JH; Goo YS; Kim CH; Kim KH. 2010. Temporal response properties of retinal ganglion cells in rd1 mice evoked by amplitude-modulated electrical pulse trains. Invest Ophthalmol Vis Sci 51(12):6762-9. [PubMed: 20671284]  [MGI Ref ID J:171389]


Sahaboglu A; Tanimoto N; Kaur J; Sancho-Pelluz J; Huber G; Fahl E; Arango-Gonzalez B; Zrenner E; Ekstrom P; Lowenheim H; Seeliger M; Paquet-Durand F. 2010. PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function. PLoS One 5(11):e15495. [PubMed: 21124852]  [MGI Ref ID J:167317]

Samardzija M; Wenzel A; Aufenberg S; Thiersch M; Reme C; Grimm C. 2006. Differential role of Jak-STAT signaling in retinal degenerations. FASEB J 20(13):2411-3. [PubMed: 16966486]  [MGI Ref ID J:114638]

Samardzija M; Wenzel A; Thiersch M; Frigg R; Reme C; Grimm C. 2006. Caspase-1 ablation protects photoreceptors in a model of autosomal dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci 47(12):5181-90. [PubMed: 17122101]  [MGI Ref ID J:123100]

Sancho-Pelluz J; Wunderlich KA; Rauch U; Romero FJ; van Veen T; Limb GA; Crocker PR; Perez MT. 2008. Sialoadhesin expression in intact degenerating retinas and following transplantation. Invest Ophthalmol Vis Sci 49(12):5602-10. [PubMed: 18641281]  [MGI Ref ID J:142000]

Sanz MM; Johnson LE; Ahuja S; Ekstrom PA; Romero J; van Veen T. 2007. Significant photoreceptor rescue by treatment with a combination of antioxidants in an animal model for retinal degeneration. Neuroscience 145(3):1120-9. [PubMed: 17293057]  [MGI Ref ID J:121644]

Sasahara M; Otani A; Oishi A; Kojima H; Yodoi Y; Kameda T; Nakamura H; Yoshimura N. 2008. Activation of bone marrow-derived microglia promotes photoreceptor survival in inherited retinal degeneration. Am J Pathol 172(6):1693-703. [PubMed: 18483210]  [MGI Ref ID J:136339]

Schmidt SY; Lolley RN. 1973. Cyclic-nucleotide phosphodiesterase: an early defect in inherited retinal degeneration of C3H mice. J Cell Biol 57(1):117-23. [PubMed: 4347974]  [MGI Ref ID J:5332]

Scott A; Powner MB; Fruttiger M. 2014. Quantification of vascular tortuosity as an early outcome measure in oxygen induced retinopathy (OIR). Exp Eye Res 120:55-60. [PubMed: 24418725]  [MGI Ref ID J:210367]

Selby CP; Thompson C; Schmitz TM; Van Gelder RN; Sancar A. 2000. Functional redundancy of cryptochromes and classical photoreceptors for nonvisual ocular photoreception in mice Proc Natl Acad Sci U S A 97(26):14697-702. [PubMed: 11114194]  [MGI Ref ID J:66580]

Semo M; Gias C; Ahmado A; Sugano E; Allen AE; Lawrence JM; Tomita H; Coffey PJ; Vugler AA. 2010. Dissecting a role for melanopsin in behavioural light aversion reveals a response independent of conventional photoreception. PLoS One 5(11):e15009. [PubMed: 21124784]  [MGI Ref ID J:167120]

Semo M; Lupi D; Peirson SN; Butler JN; Foster RG. 2003. Light-induced c-fos in melanopsin retinal ganglion cells of young and aged rodless/coneless (rd/rd cl) mice. Eur J Neurosci 18(11):3007-17. [PubMed: 14656296]  [MGI Ref ID J:89691]

Semo M; Peirson S; Lupi D; Lucas RJ; Jeffery G; Foster RG. 2003. Melanopsin retinal ganglion cells and the maintenance of circadian and pupillary responses to light in aged rodless/coneless (rd/rd cl) mice. Eur J Neurosci 17(9):1793-801. [PubMed: 12752778]  [MGI Ref ID J:128149]

Sharma AK; Rohrer B. 2007. Sustained elevation of intracellular cGMP causes oxidative stress triggering calpain-mediated apoptosis in photoreceptor degeneration. Curr Eye Res 32(3):259-69. [PubMed: 17453946]  [MGI Ref ID J:121112]

Sheedlo HJ; Jaynes D; Bolan AL; Turner JE. 1995. Mullerian glia in dystrophic rodent retinas: an immunocytochemical analysis. Brain Res Dev Brain Res 85(2):171-80. [PubMed: 7600664]  [MGI Ref ID J:24543]

Srinivasan Y; Lovicu FJ; Overbeek PA. 1998. Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts. J Clin Invest 101(3):625-34. [PubMed: 9449696]  [MGI Ref ID J:135895]

Stone C; Pinto LH. 1993. Response properties of ganglion cells in the isolated mouse retina. Vis Neurosci 10(1):31-9. [PubMed: 8424927]  [MGI Ref ID J:116795]

Strettoi E; Pignatelli V. 2000. Modifications of retinal neurons in a mouse model of retinitis pigmentosa Proc Natl Acad Sci U S A 97(20):11020-5. [PubMed: 10995468]  [MGI Ref ID J:64742]

Strettoi E; Pignatelli V; Rossi C; Porciatti V; Falsini B. 2003. Remodeling of second-order neurons in the retina of rd/rd mutant mice. Vision Res 43(8):867-77. [PubMed: 12668056]  [MGI Ref ID J:92316]

Strettoi E; Porciatti V; Falsini B; Pignatelli V; Rossi C. 2002. Morphological and functional abnormalities in the inner retina of the rd/rd mouse. J Neurosci 22(13):5492-504. [PubMed: 12097501]  [MGI Ref ID J:109225]

Sumaya IC; Masana MI; Dubocovich ML. 2005. The antidepressant-like effect of the melatonin receptor ligand luzindole in mice during forced swimming requires expression of MT2 but not MT1 melatonin receptors. J Pineal Res 39(2):170-7. [PubMed: 16098095]  [MGI Ref ID J:114318]

Takahashi M; Miyoshi H; Verma IM; Gage FH. 1999. Rescue from photoreceptor degeneration in the rd mouse by human immunodeficiency virus vector-mediated gene transfer. J Virol 73(9):7812-6. [PubMed: 10438872]  [MGI Ref ID J:56759]

Tansley K. 1954. An inherited retinal degeneration in the mouse J Hered 45:123-27.  [MGI Ref ID J:15333]

Thaung C; Arnold K; Jackson IJ; Coffey PJ. 2002. Presence of visual head tracking differentiates normal sighted from retinal degenerate mice. Neurosci Lett 325(1):21-4. [PubMed: 12023058]  [MGI Ref ID J:107978]

Thompson CL; Selby CP; Partch CL; Plante DT; Thresher RJ; Araujo F; Sancar A. 2004. Further evidence for the role of cryptochromes in retinohypothalamic photoreception/phototransduction. Brain Res Mol Brain Res 122(2):158-66. [PubMed: 15010208]  [MGI Ref ID J:88468]

Thompson S; Foster RG; Stone EM; Sheffield VC; Mrosovsky N. 2008. Classical and melanopsin photoreception in irradiance detection: negative masking of locomotor activity by light. Eur J Neurosci 27(8):1973-9. [PubMed: 18412618]  [MGI Ref ID J:136825]

Thompson S; Lupi D; Hankins MW; Peirson SN; Foster RG. 2008. The effects of rod and cone loss on the photic regulation of locomotor activity and heart rate. Eur J Neurosci 28(4):724-9. [PubMed: 18702692]  [MGI Ref ID J:140577]

Thompson S; Mullins RF; Philp AR; Stone EM; Mrosovsky N. 2008. Divergent phenotypes of vision and accessory visual function in mice with visual cycle dysfunction (Rpe65 rd12) or retinal degeneration (rd/rd). Invest Ophthalmol Vis Sci 49(6):2737-42. [PubMed: 18515598]  [MGI Ref ID J:137044]

Thompson S; Stasheff SF; Hernandez J; Nylen E; East JS; Kardon RH; Pinto LH; Mullins RF; Stone EM. 2011. Different inner retinal pathways mediate rod-cone input in irradiance detection for the pupillary light reflex and regulation of behavioral state in mice. Invest Ophthalmol Vis Sci 52(1):618-23. [PubMed: 20847113]  [MGI Ref ID J:171559]

Thyagarajan S; van Wyk M; Lehmann K; Lowel S; Feng G; Wassle H. 2010. Visual function in mice with photoreceptor degeneration and transgenic expression of channelrhodopsin 2 in ganglion cells. J Neurosci 30(26):8745-58. [PubMed: 20592196]  [MGI Ref ID J:161847]

Tochitsky I; Polosukhina A; Degtyar VE; Gallerani N; Smith CM; Friedman A; Van Gelder RN; Trauner D; Kaufer D; Kramer RH. 2014. Restoring visual function to blind mice with a photoswitch that exploits electrophysiological remodeling of retinal ganglion cells. Neuron 81(4):800-13. [PubMed: 24559673]  [MGI Ref ID J:220643]

Tsang SH; Gouras P; Yamashita CK; Kjeldbye H; Fisher J; Farber DB; Goff SP. 1996. Retinal degeneration in mice lacking the gamma subunit of the rod cGMP phosphodiesterase. Science 272(5264):1026-9. [PubMed: 8638127]  [MGI Ref ID J:33048]

Tu DC; Owens LA; Anderson L; Golczak M; Doyle SE; McCall M; Menaker M; Palczewski K; Van Gelder RN. 2006. Inner retinal photoreception independent of the visual retinoid cycle. Proc Natl Acad Sci U S A 103(27):10426-31. [PubMed: 16788071]  [MGI Ref ID J:111700]

Tu DC; Zhang D; Demas J; Slutsky EB; Provencio I; Holy TE; Van Gelder RN. 2005. Physiologic diversity and development of intrinsically photosensitive retinal ganglion cells. Neuron 48(6):987-99. [PubMed: 16364902]  [MGI Ref ID J:107606]

Tucker B; Klassen H; Yang L; Chen DF; Young MJ. 2008. Elevated MMP Expression in the MRL Mouse Retina Creates a Permissive Environment for Retinal Regeneration. Invest Ophthalmol Vis Sci 49(4):1686-95. [PubMed: 18385092]  [MGI Ref ID J:136153]

Usui S; Oveson BC; Lee SY; Jo YJ; Yoshida T; Miki A; Miki K; Iwase T; Lu L; Campochiaro PA. 2009. NADPH oxidase plays a central role in cone cell death in retinitis pigmentosa. J Neurochem 110(3):1028-37. [PubMed: 19493169]  [MGI Ref ID J:152819]

Van Gelder RN; Wee R; Lee JA; Tu DC. 2003. Reduced pupillary light responses in mice lacking cryptochromes. Science 299(5604):222. [PubMed: 12522242]  [MGI Ref ID J:81500]

Vazquez-Chona FR; Clark AM; Levine EM. 2009. Rlbp1 promoter drives robust Muller glial GFP expression in transgenic mice. Invest Ophthalmol Vis Sci 50(8):3996-4003. [PubMed: 19324864]  [MGI Ref ID J:154561]

Viczian A; Sanyal S; Toffenetti J; Chader GJ; Farber DB. 1992. Photoreceptor-specific mRNAs in mice carrying different allelic combinations at the rd and rds loci. Exp Eye Res 54(6):853-60. [PubMed: 1381682]  [MGI Ref ID J:2579]

Vlachantoni D; Bramall AN; Murphy MP; Taylor RW; Shu X; Tulloch B; Van Veen T; Turnbull DM; McInnes RR; Wright AF. 2011. Evidence of severe mitochondrial oxidative stress and a protective effect of low oxygen in mouse models of inherited photoreceptor degeneration. Hum Mol Genet 20(2):322-35. [PubMed: 21051333]  [MGI Ref ID J:166898]

Wahlin KJ; Adler R; Zack DJ; Campochiaro PA. 2001. Neurotrophic signaling in normal and degenerating rodent retinas. Exp Eye Res 73(5):693-701. [PubMed: 11747369]  [MGI Ref ID J:73377]

Wang Y; Wang ZY; Zhou MN; Cai J; Sun LY; Liu XY; Daugherty BL; Pestka S. 1997. Sequencing and bacterial expression of a novel murine alpha interferon gene. Sci China C Life Sci 40(3):277-283.  [MGI Ref ID J:41297]

Warthen DM; Wiltgen BJ; Provencio I. 2011. Light enhances learned fear. Proc Natl Acad Sci U S A 108(33):13788-93. [PubMed: 21808002]  [MGI Ref ID J:175610]

Welge-Lussen U; Wilsch C; Neuhardt T; Wayne Streilein J; Lutjen-Drecoll E. 1999. Loss of anterior chamber-associated immune deviation (ACAID) in aged retinal degeneration (rd) mice. Invest Ophthalmol Vis Sci 40(13):3209-14. [PubMed: 10586944]  [MGI Ref ID J:58745]

Won J; Shi LY; Hicks W; Wang J; Hurd R; Naggert JK; Chang B; Nishina PM. 2011. Mouse model resources for vision research. J Ophthalmol 2011:391384. [PubMed: 21052544]  [MGI Ref ID J:166679]

Wong P; Borst DE; Farber D; Danciger JS; Tenniswood M; Chader GJ; van Veen T. 1994. Increased TRPM-2/clusterin mRNA levels during the time of retinal degeneration in mouse models of retinitis pigmentosa. Biochem Cell Biol 72(9-10):439-46. [PubMed: 7605616]  [MGI Ref ID J:24128]

Wu J; Trogadis J; Bremner R. 2001. Rod and cone degeneration in the rd mouse is p53 independent. Mol Vis 7:101-6. [PubMed: 11344337]  [MGI Ref ID J:126023]

Wunderlich KA; Leveillard T; Penkowa M; Zrenner E; Perez MT. 2010. Altered expression of metallothionein-I and -II and their receptor megalin in inherited photoreceptor degeneration. Invest Ophthalmol Vis Sci 51(9):4809-20. [PubMed: 20357188]  [MGI Ref ID J:164094]

Yamada H; Yamada E; Hackett SF; Ozaki H; Okamoto N; Campochiaro PA. 1999. Hyperoxia causes decreased expression of vascular endothelial growth factor and endothelial cell apoptosis in adult retina. J Cell Physiol 179(2):149-56. [PubMed: 10199554]  [MGI Ref ID J:54326]

Yan W; Lewin A; Hauswirth W. 1998. Selective degradation of nonsense beta-phosphodiesterase mRNA in the heterozygous rd mouse. Invest Ophthalmol Vis Sci 39(13):2529-36. [PubMed: 9856762]  [MGI Ref ID J:51361]

Yang LP; Wu LM; Guo XJ; Tso MO. 2007. Activation of endoplasmic reticulum stress in degenerating photoreceptors of the rd1 mouse. Invest Ophthalmol Vis Sci 48(11):5191-8. [PubMed: 17962473]  [MGI Ref ID J:127157]

Yazulla S; Studholme KM; Pinto LH. 1997. Differences in the retinal GABA system among control, spastic mutant and retinal degeneration mutant mice. Vision Res 37(24):3471-82. [PubMed: 9425524]  [MGI Ref ID J:45280]

Yi H; Nakamura RE; Mohamed O; Dufort D; Hackam AS. 2007. Characterization of Wnt signaling during photoreceptor degeneration. Invest Ophthalmol Vis Sci 48(12):5733-41. [PubMed: 18055826]  [MGI Ref ID J:132500]

Yoshimura T; Ebihara S. 1998. Decline of circadian photosensitivity associated with retinal degeneration in CBA/J-rd/rd mice. Brain Res 779(1-2):188-93. [PubMed: 9473668]  [MGI Ref ID J:45462]

Yoshimura T; Ebihara S. 1996. Spectral sensitivity of photoreceptors mediating phase-shifts of circadian rhythms in retinally degenerate CBA/J (rd/rd) and normal CBA/N (+/+)mice. J Comp Physiol [A] 178(6):797-802. [PubMed: 8667293]  [MGI Ref ID J:33685]

Yoshimura T; Nishio M; Goto M; Ebihara S. 1994. Differences in circadian photosensitivity between retinally degenerate CBA/J mice (rd/rd) and normal CBA/N mice (+/+). J Biol Rhythms 9(1):51-60. [PubMed: 7949306]  [MGI Ref ID J:19351]

Yoshimura T; Yokota Y; Ishikawa A; Yasuo S; Hayashi N; Suzuki T; Okabayashi N; Namikawa T; Ebihara S. 2002. Mapping quantitative trait loci affecting circadian photosensitivity in retinally degenerate mice. J Biol Rhythms 17(6):512-9. [PubMed: 12465884]  [MGI Ref ID J:80788]

Zeiss CJ; Johnson EA. 2004. Proliferation of microglia, but not photoreceptors, in the outer nuclear layer of the rd-1 mouse. Invest Ophthalmol Vis Sci 45(3):971-6. [PubMed: 14985319]  [MGI Ref ID J:109731]

Zeiss CJ; Neal J; Johnson EA. 2004. Caspase-3 in postnatal retinal development and degeneration. Invest Ophthalmol Vis Sci 45(3):964-70. [PubMed: 14985318]  [MGI Ref ID J:88367]

Zencak D; Crippa SV; Tekaya M; Tanger E; Schorderet DE; Munier FL; van Lohuizen M; Arsenijevic Y. 2006. BMI1 loss delays photoreceptor degeneration in Rd1 mice. Bmi1 loss and neuroprotection in Rd1 mice. Adv Exp Med Biol 572:209-15. [PubMed: 17249577]  [MGI Ref ID J:154016]

Zencak D; Schouwey K; Chen D; Ekstrom P; Tanger E; Bremner R; van Lohuizen M; Arsenijevic Y. 2013. Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins. Proc Natl Acad Sci U S A 110(7):E593-601. [PubMed: 23359713]  [MGI Ref ID J:194322]

Zeng H; Ding M; Chen XX; Lu Q. 2014. Microglial NADPH oxidase activation mediates rod cell death in the retinal degeneration in rd mice. Neuroscience 275:54-61. [PubMed: 24929065]  [MGI Ref ID J:215397]

Zeng HY; Lu QJ; Liu Q; Liu KG; Wang NL. 2011. The role of CCR1 expression in the retinal degeneration in rd mice. Curr Eye Res 36(3):264-9. [PubMed: 21275605]  [MGI Ref ID J:179793]

Zhang N; Kolesnikov AV; Jastrzebska B; Mustafi D; Sawada O; Maeda T; Genoud C; Engel A; Kefalov VJ; Palczewski K. 2013. Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. J Clin Invest 123(1):121-37. [PubMed: 23221340]  [MGI Ref ID J:194158]

Zhu Y; Tu DC; Denner D; Shane T; Fitzgerald CM; Van Gelder RN. 2007. Melanopsin-dependent persistence and photopotentiation of murine pupillary light responses. Invest Ophthalmol Vis Sci 48(3):1268-75. [PubMed: 17325172]  [MGI Ref ID J:123259]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryThis B2mtm1Unc strain is maintained by mating homozygous siblings. Only homozygous mice may be ordered.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing


Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2625.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing


Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3412.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

   000659 C3H/HeJ
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Important Note

This strain is homozygous for the retinal degeneration allele Pde6brd1.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.