Description

Strain Information

Type Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Generation F?+5N1p

Development
The semi-dominant mutation lurcher Jackson (Grid2^Lc-J) arose spontaneously in the inbred strain BALB/cByJ at The Jackson Laboratory in 1993. The stock was maintained by mating a heterozygote with a wild type (+/+) sibling. It was cryopreserved in 1995 by mating C57BL/6J females with heterozygous males at generation F?+5 to generate embryos.

Related Strains

Strains carrying other alleles of Grid2

000593	B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J
001046	B6CBACa Aw-J/A-Grid2Lc/J
005447	C57BL/6J-Grid2ho-16J/J
005718	C57BL/6J-Grid2ho-17J/J
000527	C57BL/6J-Grid2ho-5J/J
000548	DBA/2J-Grid2ho-4J/J

View Strains carrying other alleles of Grid2     (6 strains)

Phenotype

Phenotype Information

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Grid2^Lc-J related

Developmental Biology Research
Embryonic Lethality (Homozygous)

Neurobiology Research
Ataxia (Movement) Defects
Cerebellar Defects
Receptor Defects (glutamate receptor: ionotropic)

Currently there is no phenotype information for this strain.

Genes & Alleles

Gene & Allele Information

Allele Symbol		Grid2Lc-J
Allele Name		lurcher Jackson
Allele Type		Spontaneous
Common Name(s)		lc;
Strain of Origin		BALB/cByJ
Gene Symbol and Name		Grid2, glutamate receptor, ionotropic, delta 2
Chromosome		6
Gene Common Name(s)		B230104L07Rik; GluRdelta2; Lc; LcJ; MGC117022; MGC117023; MGC117024; RIKEN cDNA B230104L07 gene; cpr; creeper; ho; hotfoot; lurcher; lurcher Jackson; neuroscience mutagenesis facility, 408; nmf408; tapdancer; tpr;
General Note		The lurcher Jackson mutation arose spontaneously in a BALB/cByJ stock at The Jackson Laboratory (J:42385), and was determined to be a mutation the Grid2 gene (J:42431). It causes early cerebellar Purkinje cell loss and development of ataxia in heterozygotes. Homozygotes die early in life, many perinatally. The phenotype resembles that of lurcher; the mutation maps to the same segment of Chr 6; and complementation is lacking in offspring of test crosses (J:42385).
Molecular Note		The lurcher (Grid2Lc) and lurcher-J (Grid2Lc-J) mutations are nucleotide substitutions that cause a change in an amino acid in the third transmembrane domain of Grid2. [MGI Ref ID J:42431]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

Norman DJ; Feng L; Cheng SS; Gubbay J; Chan E; Heintz N. 1995. The lurcher gene induces apoptotic death in cerebellar Purkinje cells. Development 121(4):1183-93. [PubMed: 7743930]  [MGI Ref ID J:24329]

Zuo J; De Jager PL; Takahashi KA; Jiang W; Linden DJ; Heintz N. 1997. Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene [see comments] Nature 388(6644):769-73. [PubMed: 9285588]  [MGI Ref ID J:42431]

Grid2^Lc-J related

De Jager PL; Zuo J; Cook SA; Heintz N. 1997. A new allele of the lurcher gene, lurcherJ. Mamm Genome 8(9):647-50. [PubMed: 9271665]  [MGI Ref ID J:42385]

Doughty ML; De Jager PL; Korsmeyer SJ; Heintz N. 2000. Neurodegeneration in Lurcher mice occurs via multiple cell death pathways. J Neurosci 20(10):3687-94. [PubMed: 10804210]  [MGI Ref ID J:62117]

Zuo J; De Jager PL; Takahashi KA; Jiang W; Linden DJ; Heintz N. 1997. Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene [see comments] Nature 388(6644):769-73. [PubMed: 9285588]  [MGI Ref ID J:42431]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.

Supply Notes

Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

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phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

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