Strain Name: |
129S1/SvImJ |
|---|---|
Stock Number: |
002448 |
Availability: | Level 2 |
General Terms and Conditions |
| Former Name |
129/SvImJ (Changed: 15-DEC-04
) |
|
129S1/Sv-p+ Tyr+ Kitl+ (Changed: 15-DEC-04
) | |
|
129S3/SvIm (Changed: 15-DEC-04
) | |
|
129S3/SvImJ (Changed: 15-DEC-04
) | |
| Genes & Alleles | Disc1; Disc1del; Gnat2; Gnat2cpfl3; |
Product Information
Strain Details
Type Inbred Strain Additional information on Inbred Strains. Mating System Sibling x Sibling (Female x Male) Species laboratory mouse H2 Haplotype b Generation F67 (03-JAN-08) Appearance
white-bellied agouti
Related Genotype: Aw/AwImportant Note
This strain is homozygous for Gnat2cpfl3, cone photoreceptor function loss 3, which affects bright light (photopic) vision.Strain Description
Historically, the 129 inbred mice are known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains.(1-3% in 129 parental substrains; 30% in teratoma substrains.) More recently, 129 mice are widely used in the production of targeted mutations due to the availability of multiple embryonic stem cell lines derived from them. There is major genetic variation within the 129 "family", which has led to an update of the nomenclature and a division of the substrains into three major groups: parental substrains (129P), steel substrains (129S) and "teratoma" substrains (129T). Investigators using 129 substrains for targeted mutagenesis should be careful in the selection of the appropriate 129 substrain to match the embryonic stem cell line. For a complete history of the numerous 129 substrains, see Simpson, et al., 1997.In response to challenge, 129S1/SvImJ mice develop immune-mediated nephritis characterized by proteinuria, glomerulonephritis and tubulointerstitial disease (Xie et al., 2004).
Strain Development
129S1/SvImJ was developed to serve as a control inbred strain for many of the steel-derived ES cell lines (e.g. W9.5 and CJ7). SSLP marker analysis indicates that 129S1/SvImJ is identical to 129S1/Sv +p +Tyr-c KitlSl-J/+ except for the region surrounding the Kitl gene on Chr 10. 129S1/SvImJ was derived from 129S1/Sv-+p +Tyr-c KitlSl-J/+ (Stock No. 000090). The steel-Jackson mutation (KitlSl-J, formerly MgfSl-J), is segregating in Stock No. 000090. KitlSl-J was removed in 1995, at F26, by selective breeding to produce 129/Sv-+p +Tyr-c +Kitl-SlJ (Stock No. 002448, see Simpson et al., 1997). This name was later shortened to simply 129/SvImJ. Subsequently designated 129S3/SvImJ (Festing et al., 1999), this strain was renamed 129S1/SvImJ in February, 2001 to emphasize its relationship to Stock No. 000090.
Gene & Allele Details
| Allele Symbol | Disc1del | ||
|---|---|---|---|
| Allele Name | deletion | ||
| Common Name(s) | Disc1129S6; | ||
| Strain of Origin | various | ||
| Gene Symbol and Name | Disc1, disrupted in schizophrenia 1 | ||
| Chromosome | 8 | ||
| Gene Common Name(s) | KIAA0457; SCZD9; | ||
| General Note | This deletion appears in multiple strains of the 129 superfamily. See J:111837 for details. This deletion has further been identified in the following strains:101/RI, BTBR T+ Tf/J and LP/J J:118317 | ||
| Molecular Note | A 25 bp deletion of the locus causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon at exon 7. [MGI Ref ID J:107244] | ||
| Allele Symbol | Gnat2cpfl3 | ||
| Allele Name | cone photoreceptor function loss 3 | ||
| Common Name(s) | Gnat2; | ||
| Strain of Origin | various | ||
| Gene Symbol and Name | Gnat2, guanine nucleotide binding protein, alpha transducing 2 | ||
| Chromosome | 3 | ||
| Gene Common Name(s) | ACHM4; AW490837; GNATC; Gnat-2; Gt-2; Tcalpha; expressed sequence AW490837; | ||
| General Note |
This allele has been detected in the following strains either by genotyping or complementation testing: ALS/LtJ, SENCARA/PtJ, SENCARB/PtJ, SENCARC/PtJ, PN/nBSwUmabJ. (J:122428) Phenotypic Similarity to Human Syndrome in Orthologous Human Gene: OMIM +139340 ACHROMATOPSIA 4. | ||
| Molecular Note | A single nucleotide substitution of G to A at position 598 in exon 6. This mutation converts codon 200 from apartic acid to asparagine. [MGI Ref ID J:122428] | ||
Colony Maintenance
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Related Strains
129 Strains
001137 129P1/ReJ 000690 129P3/J 002357 129P3/JEmsJ 001198 129P4/RrRkJ 002064 129T2/SvEms 002065 129T2/SvEmsJ 000691 129X1/SvJ View 129 Strains (7 strains)
001137 129P1/ReJ 000690 129P3/J 001198 129P4/RrRkJ 002064 129T2/SvEms 002065 129T2/SvEmsJ 000691 129X1/SvJ 002282 BTBR T+ tf/J 000676 LP/J
003072 ALS/LtJ 006180 CD10/JlsJ 005052 PN/nBSwUmabJ 002746 SENCARA/PtJ 002747 SENCARB/PtJ 002748 SENCARC/PtJ 006135 STOCK Sgk3fz-ica/McirJ 003773 STOCK Tg(CAG-ECFP)CK6Nagy/J 005645 STOCK Tg(CAG-mRFP1)1F1Hadj/J 004623 STOCK Tg(Fos-lacZ)34Efu/J 005667 STOCK Tg(Neurog3-cre)C1Able/J 003262 STOCK Tg(Trp53A135V)L3Ber/J 005104 STOCK Tg(tetO-HIST1H2BJ/GFP)47Efu/J 005699 STOCK Tg(tetO-Ipf1,EGFP)956.6Macd/J
Phenotypic Data
Mouse Phenome Database
Mouse Phenome Database / SNP Facility
Festing Inbred Strain Characteristics: 129
Additional Web Information
Genetic Quality Control Annual Report
JAX Notes, Winter 2006; 504. JAX® Mice: the Gold Standard Just Got Better.
National Center for Biotechnology Information / SNP Data
New 129 Nomenclature Bulletin
Animal Health Reports
Room Number AX4
Research Applications
This mouse can be used to support research in many areas including:
Cancer Research
Increased Tumor Incidence (Gonadal Tumors: testicular teratomas)
Reproductive Biology Research
Gonadal Tumors (testicular teratomas)
Research Tools
General Purpose
Genetics Research (Mutagenesis and Transgenesis: Production of Targeted Mutations ("Knockouts"))
References
Selected Reference(s)
Additional ReferencesFesting MF; Simpson EM; Davisson MT; Mobraaten LE. 1999. Revised nomenclature for strain 129 mice. Mamm Genome 10(8):836. [PubMed: 10430671] [MGI Ref ID J:56500]
Simpson EM; Linder CC; Sargent EE; Davisson MT; Mobraaten LE; Sharp JJ. 1997. Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice. Nat Genet 16(1):19-27. [PubMed: 9140391] [MGI Ref ID J:40222]
Stevens LC. 1973. A new inbred subline of mice (129-terSv) with a high incidence of spontaneous congenital testicular teratomas. J Natl Cancer Inst 50(1):235-42. [PubMed: 4692863] [MGI Ref ID J:29502]
Threadgill DW; Yee D; Matin A; Nadeau JH; Magnuson T. 1997. Genealogy of the 129 inbred strains: 129/SvJ is a contaminated inbred strain. Mamm Genome 8(6):390-3. [PubMed: 9166580] [MGI Ref ID J:40661]
Price and Supply Information
| Strain Name: | 129S1/SvImJ |
| Stock Number: | 002448 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
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Supply Details
| Standard Supply | Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request. |
|---|---|
| Supply Notes |
Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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