Description

Strain Information

Former Names 129/SvImJ    (Changed: 15-DEC-04 ) 129S1/Sv-p+ Tyr+ Kitl+    (Changed: 15-DEC-04 ) 129S3/SvIm    (Changed: 15-DEC-04 ) 129S3/SvImJ    (Changed: 15-DEC-04 ) Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling         (Female x Male) Species laboratory mouse H2 Haplotype b Generation F67 (03-JAN-08)

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Appearance
white-bellied agouti
Related Genotype: A^w/A^w

Description
Historically, the 129 inbred mice are known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains.(1-3% in 129 parental substrains; 30% in teratoma substrains.) More recently, 129 mice are widely used in the production of targeted mutations due to the availability of multiple embryonic stem cell lines derived from them. There is major genetic variation within the 129 "family", which has led to an update of the nomenclature and a division of the substrains into three major groups: parental substrains (129P), steel substrains (129S) and "teratoma" substrains (129T). Investigators using 129 substrains for targeted mutagenesis should be careful in the selection of the appropriate 129 substrain to match the embryonic stem cell line. For a complete history of the numerous 129 substrains, see Simpson, et al., 1997.

Development
129S1/SvImJ was developed to serve as a control inbred strain for many of the steel-derived ES cell lines (e.g. W9.5 and CJ7). SSLP marker analysis indicates that 129S1/SvImJ is identical to 129S1/Sv +^Oca2-p +^Tyr-c Kitl^Sl-J/+ except for the region surrounding the Kitl gene on Chr 10. 129S1/SvImJ was derived from 129S1/Sv-+^Oca2-p +^Tyr-c Kitl^Sl-J/+ (Stock No. 000090). The steel-Jackson mutation (Kitl^Sl-J, formerly Mgf^Sl-J), is segregating in Stock No. 000090. Kitl^Sl-J was removed in 1995, at F26, by selective breeding to produce 129/Sv-+^Oca2-p +^Tyr-c +^Kitl-SlJ (Stock No. 002448, see Simpson et al., 1997). This name was later shortened to simply 129/SvImJ. Subsequently designated 129S3/SvImJ (Festing et al., 1999), this strain was renamed 129S1/SvImJ in February, 2001 to emphasize its relationship to Stock No. 000090.

Related Strains

129 Strains

001137	129P1/ReJ
000690	129P3/J
002357	129P3/JEmsJ
001198	129P4/RrRkJ
002064	129T2/SvEms
002065	129T2/SvEmsJ
000691	129X1/SvJ
001924	B6EiC3Sn a/A-Ts(1716)65Dn

View 129 Strains     (8 strains)

Strains carrying   Disc1^del allele

001137	129P1/ReJ
000690	129P3/J
001198	129P4/RrRkJ
002064	129T2/SvEms
002065	129T2/SvEmsJ
000691	129X1/SvJ
002282	BTBR T+ tf/J
000676	LP/J

View Strains carrying   Disc1^del     (8 strains)

Additional Web Information

Genetic Quality Control Annual Report
JAX^® NOTES, Winter 2006; 504. JAX^® Mice: the Gold Standard Just Got Better.
National Center for Biotechnology Information / SNP Data
New 129 Nomenclature Bulletin

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Mouse Phenome Database
Mouse Phenome Database / SNP Facility
Festing Inbred Strain Characteristics: 129

Genes & Alleles

Gene & Allele Information

Allele Symbol		Disc1del
Allele Name		deletion
Allele Type		Spontaneous
Common Name(s)		Disc1129S6;
Strain of Origin		various
Gene Symbol and Name		Disc1, disrupted in schizophrenia 1
Chromosome		8
Gene Common Name(s)		C1orf136; FLJ13381; FLJ21640; FLJ25311; FLJ41105; KIAA0457; SCZD9;
General Note		This deletion appears in multiple strains of the 129 superfamily. See J:111837 for details. This deletion has further been identified in the following strains:101/RI, BTBR T+ tf/J and LP/J J:118317
Molecular Note		A 25 bp deletion of the locus causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon at exon 7. [MGI Ref ID J:107244]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Selected Reference(s)

Festing MF; Simpson EM; Davisson MT; Mobraaten LE. 1999. Revised nomenclature for strain 129 mice. Mamm Genome 10(8):836. [PubMed: 10430671]  [MGI Ref ID J:56500]

Simpson EM; Linder CC; Sargent EE; Davisson MT; Mobraaten LE; Sharp JJ. 1997. Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice. Nat Genet 16(1):19-27. [PubMed: 9140391]  [MGI Ref ID J:40222]

Threadgill DW; Yee D; Matin A; Nadeau JH; Magnuson T. 1997. Genealogy of the 129 inbred strains: 129/SvJ is a contaminated inbred strain. Mamm Genome 8(6):390-3. [PubMed: 9166580]  [MGI Ref ID J:40661]

Additional References

Clapcote SJ; Roder JC. 2006. Deletion polymorphism of disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function. Genetics 173(4):2407-10. [PubMed: 16751659]  [MGI Ref ID J:111837]

Moy SS; Nadler JJ; Young NB; Perez A; Holloway LP; Barbaro RP; Barbaro JR; Wilson LM; Threadgill DW; Lauder JM; Magnuson TR; Crawley JN. 2007. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res 176(1):4-20. [PubMed: 16971002]  [MGI Ref ID J:138682]

Rohan RM; Fernandez A; Udagawa T; Yuan J; D'Amato RJ. 2000. Genetic heterogeneity of angiogenesis in mice. FASEB J 14(7):871-6. [PubMed: 10783140]  [MGI Ref ID J:61808]

Stevens LC. 1973. A new inbred subline of mice (129-terSv) with a high incidence of spontaneous congenital testicular teratomas. J Natl Cancer Inst 50(1):235-42. [PubMed: 4692863]  [MGI Ref ID J:29502]

Wahlsten D; Metten P; Crabbe JC. 2003. Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum. Brain Res 971(1):47-54. [PubMed: 12691836]  [MGI Ref ID J:83159]

Whitehead GS; Walker JK; Berman KG; Foster WM; Schwartz DA. 2003. Allergen-induced airway disease is mouse strain dependent. Am J Physiol Lung Cell Mol Physiol 285(1):L32-42. [PubMed: 12626335]  [MGI Ref ID J:84265]

Disc1^del related

Clapcote SJ; Roder JC. 2006. Deletion polymorphism of disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function. Genetics 173(4):2407-10. [PubMed: 16751659]  [MGI Ref ID J:111837]

Clapcote SJ; Roder JC. 2007. Inbred mouse strains 101/RI, BTBR T tf/J and LP/J have a deletion in Disc1 MGI Direct Data Submission :.  [MGI Ref ID J:118317]

Koike H; Arguello PA; Kvajo M; Karayiorgou M; Gogos JA. 2006. Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc Natl Acad Sci U S A 103(10):3693-7. [PubMed: 16484369]  [MGI Ref ID J:107244]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX4

Colony Maintenance

Mating System	Sibling x Sibling         (Female x Male)
Diet Information	LabDiet® 5K52/5K67

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Standard Supply	Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.
Supply Notes	Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. Genomic DNA is available for this strain from the Mouse DNA Resource.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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