Strain Name:

129S1/SvImJ

Stock Number:

002448

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Level 2

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129 mice are widely used in the production of targeted mutations due to the availability of multiple embryonic stem cell lines derived from them. They also have a high incidence of spontaneous testicular teratomas.

Description

Strain Information

Former Names 129/SvImJ    (Changed: 15-DEC-04 )
129S1/Sv-p+ Tyr+ Kitl+    (Changed: 15-DEC-04 )
129S3/SvIm    (Changed: 15-DEC-04 )
129S3/SvImJ    (Changed: 15-DEC-04 )
Type Inbred Strain;
Additional information on Inbred Strains.
Visit our online Nomenclature tutorial.
Mating SystemSibling x Sibling         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a good breeder.
Specieslaboratory mouse
H2 Haplotypeb
GenerationF63pF3 (14-AUG-14)
Generation Definitions

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Appearance
white-bellied agouti
Related Genotype: Aw/Aw

Description
Historically, the 129 inbred mice are known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains.(1-3% in 129 parental substrains; 30% in teratoma substrains.) More recently, 129 mice are widely used in the production of targeted mutations due to the availability of multiple embryonic stem cell lines derived from them. There is major genetic variation within the 129 "family", which has led to an update of the nomenclature and a division of the substrains into three major groups: parental substrains (129P), steel substrains (129S) and "teratoma" substrains (129T). Investigators using 129 substrains for targeted mutagenesis should be careful in the selection of the appropriate 129 substrain to match the embryonic stem cell line. For a complete history of the numerous 129 substrains, see Simpson, et al., 1997.

Development
129S1/SvImJ was developed to serve as a control inbred strain for many of the steel-derived ES cell lines (e.g. W9.5 and CJ7). SSLP marker analysis indicates that 129S1/SvImJ is identical to 129S1/Sv +Oca2-p +Tyr-c KitlSl-J/+ except for the region surrounding the Kitl gene on Chr 10. 129S1/SvImJ was derived from 129S1/Sv-+Oca2-p +Tyr-c KitlSl-J/+ (Stock No. 000090). The steel-Jackson mutation (KitlSl-J, formerly MgfSl-J), is segregating in Stock No. 000090. KitlSl-J was removed in 1995, at F26, by selective breeding to produce 129/Sv-+Oca2-p +Tyr-c +Kitl-SlJ (Stock No. 002448, see Simpson et al., 1997). This name was later shortened to simply 129/SvImJ. Subsequently designated 129S3/SvImJ (Festing et al., 1999), this strain was renamed 129S1/SvImJ in February, 2001 to emphasize its relationship to Stock No. 000090.

Related Strains

129 Strains
001137   129P1/ReJ
000690   129P3/J
002357   129P3/JEmsJ
001198   129P4/RrRkJ
009104   129S4/SvJaeJ
012809   129S8/SvEvNimrJ
002064   129T2/SvEms
002065   129T2/SvEmsJ
000691   129X1/SvJ
View 129 Strains     (9 strains)

Strains carrying   Disc1del allele
001137   129P1/ReJ
000690   129P3/J
001198   129P4/RrRkJ
002064   129T2/SvEms
002065   129T2/SvEmsJ
000691   129X1/SvJ
002282   BTBR T+ Itpr3tf/J
002243   DDY/JclSidSeyFrkJ
001800   FVB/NJ
000676   LP/J
000686   SJL/J
000689   SWR/J
View Strains carrying   Disc1del     (12 strains)

Additional Web Information

JAX® NOTES, Winter 2006; 504. JAX® Mice: the Gold Standard Just Got Better.
Mouse Phenome Database / SNP Facility
National Center for Biotechnology Information / SNP Data
New 129 Nomenclature Bulletin
Request a copy of our Gene Targeting with 129 Strains poster.

Phenotype

Phenotype Information

View Phenotypic Data

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Schizophrenia 9; SCZD9   (DISC1)
Schizophrenia; SCZD   (DISC1)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cancer Research
Increased Tumor Incidence
      Gonadal Tumors
      Gonadal Tumors: testicular teratomas

Neurobiology Research
Neurodevelopmental Defects
      callosal agenesis, incomplete penetrance

Reproductive Biology Research
Gonadal Tumors
      testicular teratomas

Research Tools
General Purpose
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Production of Targeted Mutations (Knockouts)
Infectious Disease
      Anthrax

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Disc1del
Allele Name deletion
Allele Type Spontaneous
Common Name(s) Disc1129S6; Disc1delta6;
Strain of Originvarious
Gene Symbol and Name Disc1, disrupted in schizophrenia 1
Chromosome 8
Gene Common Name(s) C1orf136; SCZD9;
General Note This deletion appears in multiple strains of the 129 superfamily, 101/RI, BTBR T+ tf/J, LP/J, FVB/NJ, SJL/J, SWR/J and DDY/JclSidSeyFrkJ (J:111837, J:195189).
Molecular Note A 25 bp deletion of the locus causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon at exon 7. [MGI Ref ID J:107244]

Genotyping

Genotyping Information

Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Festing MF; Simpson EM; Davisson MT; Mobraaten LE. 1999. Revised nomenclature for strain 129 mice. Mamm Genome 10(8):836. [PubMed: 10430671]  [MGI Ref ID J:56500]

Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. [PubMed: 15081119]  [MGI Ref ID J:89298]

Simpson EM; Linder CC; Sargent EE; Davisson MT; Mobraaten LE; Sharp JJ. 1997. Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice. Nat Genet 16(1):19-27. [PubMed: 9140391]  [MGI Ref ID J:40222]

Threadgill DW; Yee D; Matin A; Nadeau JH; Magnuson T. 1997. Genealogy of the 129 inbred strains: 129/SvJ is a contaminated inbred strain. Mamm Genome 8(6):390-3. [PubMed: 9166580]  [MGI Ref ID J:40661]

Additional References

Clapcote SJ; Roder JC. 2006. Deletion polymorphism of disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function. Genetics 173(4):2407-10. [PubMed: 16751659]  [MGI Ref ID J:111837]

Keane TM; Goodstadt L; Danecek P; White MA; Wong K; Yalcin B; Heger A; Agam A; Slater G; Goodson M; Furlotte NA; Eskin E; Nellaker C; Whitley H; Cleak J; Janowitz D; Hernandez-Pliego P; Edwards A; Belgard TG; Oliver PL; McIntyre RE; Bhomra A; Nicod J; Gan X; Yuan W; van der Weyden L; Steward CA; Bala S; Stalker J; Mott R; Durbin R; Jackson IJ; Czechanski A; Guerra-Assuncao JA; Donahue LR; Reinholdt LG; Payseur BA; Ponting CP; Birney E; Flint J; Adams DJ. 2011. Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 477(7364):289-94. [PubMed: 21921910]  [MGI Ref ID J:177037]

Moy SS; Nadler JJ; Young NB; Perez A; Holloway LP; Barbaro RP; Barbaro JR; Wilson LM; Threadgill DW; Lauder JM; Magnuson TR; Crawley JN. 2007. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res 176(1):4-20. [PubMed: 16971002]  [MGI Ref ID J:138682]

Rohan RM; Fernandez A; Udagawa T; Yuan J; D'Amato RJ. 2000. Genetic heterogeneity of angiogenesis in mice. FASEB J 14(7):871-6. [PubMed: 10783140]  [MGI Ref ID J:61808]

Stevens LC. 1973. A new inbred subline of mice (129-terSv) with a high incidence of spontaneous congenital testicular teratomas. J Natl Cancer Inst 50(1):235-42. [PubMed: 4692863]  [MGI Ref ID J:29502]

Wahlsten D; Metten P; Crabbe JC. 2003. Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum. Brain Res 971(1):47-54. [PubMed: 12691836]  [MGI Ref ID J:83159]

Whitehead GS; Walker JK; Berman KG; Foster WM; Schwartz DA. 2003. Allergen-induced airway disease is mouse strain dependent. Am J Physiol Lung Cell Mol Physiol 285(1):L32-42. [PubMed: 12626335]  [MGI Ref ID J:84265]

Disc1del related

Clapcote SJ; Roder JC. 2006. Deletion polymorphism of disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function. Genetics 173(4):2407-10. [PubMed: 16751659]  [MGI Ref ID J:111837]

Clapcote SJ; Roder JC. 2007. Inbred mouse strains 101/RI, BTBR T tf/J and LP/J have a deletion in Disc1 MGI Direct Data Submission :.  [MGI Ref ID J:118317]

Koike H; Arguello PA; Kvajo M; Karayiorgou M; Gogos JA. 2006. Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc Natl Acad Sci U S A 103(10):3693-7. [PubMed: 16484369]  [MGI Ref ID J:107244]

Kuroda K; Yamada S; Tanaka M; Iizuka M; Yano H; Mori D; Tsuboi D; Nishioka T; Namba T; Iizuka Y; Kubota S; Nagai T; Ibi D; Wang R; Enomoto A; Isotani-Sakakibara M; Asai N; Kimura K; Kiyonari H; Abe T; Mizoguchi A; Sokabe M; Takahashi M; Yamada K; Kaibuchi K. 2011. Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. Hum Mol Genet 20(23):4666-83. [PubMed: 21903668]  [MGI Ref ID J:177560]

Ritchie D; Clapcote S. 2013. Disc1 deletion is present in Swiss-derived inbred mouse strains: implications for transgenic studies of learning and memory. Lab Anim :. [PubMed: 23563120]  [MGI Ref ID J:195189]

Zou H; Yu Y; Sheikh AM; Malik M; Yang K; Wen G; Chadman KK; Brown WT; Li X. 2011. Association of upregulated Ras/Raf/ERK1/2 signaling with autism. Genes Brain Behav 10(5):615-24. [PubMed: 21595826]  [MGI Ref ID J:185685]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX4

Colony Maintenance

Mating SystemSibling x Sibling         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a good breeder.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)Gender
3 weeks $42.60Female or Male  
4 weeks $42.60Female or Male  
5 weeks $42.60Female or Male  
6 weeks $48.00Female or Male  
7 weeks $48.00Female or Male  
8 weeks $48.00Female or Male  
9 weeks $48.00Female or Male  
10 weeks $55.00Female or Male  

Standard Supply

Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.

Cryopreserved

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)Gender
3 weeks $55.40Female or Male  
4 weeks $55.40Female or Male  
5 weeks $55.40Female or Male  
6 weeks $62.40Female or Male  
7 weeks $62.40Female or Male  
8 weeks $62.40Female or Male  
9 weeks $62.40Female or Male  
10 weeks $71.50Female or Male  

Standard Supply

Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.

Cryopreserved

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.

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