Strain Name:

KK.Cg-Ay/J

Stock Number:

002468

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Availability:

Level 4

Mice homozygous for the yellow spontaneous mutation (Ay) die before implantation or shortly thereafter. Heterozygotes usually become obese and infertile within a few months after birth. Heterozygotes are more susceptible to several kinds of tumors than are normal mice. Further, spleen cells from heterozygotes cause a significantly lower graft vs. host reaction. Mice of the KK strain develop diabetes of polygenic origin, and KK.Cg-Ay/J heterozygotes develop hyperglycemia, hyperinsulinemia, glucose intolerance and obesity by eight weeks of age. Pancreatic islets are hypertrophied and the β-cells are degranulated. Both the fat and lean tissue mass are increased compared to non-obese mice, with fat accounting for 30-35% of total body weight.

Description

Strain Information

Type Congenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating System+/+ sibling x Heterozygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a good breeder.
Specieslaboratory mouse
Background Strain KK/Upj
Donor Strain Fancier
H2 Haplotypeb
GenerationN?F101 (24-SEP-12)
Generation Definitions

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Appearance
yellow, affected
Related Genotype: Ay/a

black, unaffected
Related Genotype: a/a

Important Note
It has been reported that the KK strain is hemolytic complement deficient (Hc0), however, our strains have not been tested to confirm this allele. (Cinader B, et al.,2004, J Exp Med,120:897)

Description
Ay and other mutations at the a locus conferring a completely yellow coat color are dominant to all a alleles that produce a darker coat. Hair pigment of Ay heterozygotes is yellow, but eyes are black. Heterozygotes usually become obese and infertile within a few months after birth. Increased adipose tissue mass is due to fat cell hypertrophy, and it has been hypothesized that the obesity results from the observed reduction in hypothalamic norepinephrine and dopamine. Heterozygotes are more susceptible to several kinds of tumors than are normal mice, possibly due, at least in part, to a general increase in cell proliferation that also manifests as a slight increase in lean body mass and skeletal length. Further spleen cells from heterozygotes cause a significantly lower graft vs. host reaction. Mice homozygous for the yellow spontaneous mutation (Ay) die before implantation, or shortly thereafter. The time of death and type of abnormality is, in part, determined by the genetic background on which the mutation is placed. Mice of the KK strain develop diabetes of polygenic origin, and mice of other strains heterozygous for Ay become obese and mildly diabetic. KK.Cg-Ay/J heterozygotes develop hyperglycemia, hyperinsulinemia, glucose intolerance and obesity by eight weeks of age. Studies using isolated adipocytes indicate that tissue responsiveness to insulin is decreased. Histo- and immunocytochemical studies show that the pancreatic islets are hypertrophied and the β-cells are degranulated. These findings suggest that the principal cause of diabetes in these mice is insulin resistance. Body composition analysis shows that both the fat and lean tissue mass are increased compared to non-obese mice, with fat accounting for 30-35% of total body weight. The pleiotropic mutant phenotype of Ay/a mice is attributed to ectopic expression of the agouti protein, while the early embryonic lethality of the Ay mutation in the homozygous state is assumed to result from lack of expression of the Raly gene product (Bultman et al. 1992, Miller et al. 1993, Duhl et al. 1994, Michaud et al. 1993, 1994). That ectopic expression of the agouti protein is probably responsible for the non-lethal aspects of this mutation has been demonstrated by transgenic expression of the protein from a ubiquitous promoter (Klebig et al. 1995, Perry et al. 1995).

For further information, see Mouse Genome Informatics entries for a and for Raly and Michael F.W. Festing's description of KK.

Development
The Ay mutation was introduced onto the KK strain background by Dr. Nishimura in Japan. The Upjohn (Upj) colony of KK-Ay mice was initiated from mice acquired from Takeda Chemical Industries (Osaka, Japan) by Dr. George Gerritsen in 1983, at which time they had been inbred for 100 generations. The original KK-Ay strain was developed following initial crosses of Ay/a mice with mice of one of the inbred KK strains established from native Japanese mice (Kondo et al. 1957). As the diabetic characteristics of KK mice are generally considered to be of polygenic origin (Coleman 1982, Reddi and Camerini-Davalos 1988) and as Kondo established multiple sublines of KK mice, it is uncertain how closely related KK.Cg-Ay/J is to other KK strains. The Jackson Laboratory distributes the KK/HlJ (Stock No. 002106) obtained from Dr. Leiselotte Herberg at the Diabetes Research Institute in Dusseldorf, Germany. Additional backgrounds available: C57BL/6J-Ay.

Control Information

  Control
   a/a from the colony
   See control note: Normal wildtype nonagouti (a/a) mice from the colony or KK/HlJ (Stock No. 002106) mice may be used as controls; the latter is only an approximate control whose degree of relationship to KK.Cg-Ay/J is uncertain (See Strain Development).
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Ay allele
000021   B6.Cg-Ay/J
View Strains carrying   Ay     (1 strain)

Strains carrying other alleles of a
002655   Mus pahari/EiJ
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000433   B10.C-H3c H13? A/(28NX)SnJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000423   B10.KR-H13? A/SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Bloc1s6pa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
003879   B10;TFLe-a/a T Itpr3tf/+ Itpr3tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
000593   B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J
000502   B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J
000599   B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J
002083   B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507   B6 x B6EiC3 a/A-Otcspf/J
003759   B6 x B6EiC3Sn a/A-T(10;16)232Dn/J
002071   B6 x B6EiC3Sn a/A-T(11;17)202Dn/J
002113   B6 x B6EiC3Sn a/A-T(11A2;16B3)238Dn/J
002068   B6 x B6EiC3Sn a/A-T(11B1;16B5)233Dn/J
002069   B6 x B6EiC3Sn a/A-T(14E4or5;16B5)225Dn/J
001926   B6 x B6EiC3Sn a/A-T(15;16)198Dn/J
001832   B6 x B6EiC3Sn a/A-T(15E;16B1)60Dn/J
003758   B6 x B6EiC3Sn a/A-T(16C3-4;17A2)65Dn/J
001833   B6 x B6EiC3Sn a/A-T(1C2;16C3)45Dn/J
001903   B6 x B6EiC3Sn a/A-T(6F;18C)57Dn/J
001535   B6 x B6EiC3Sn a/A-T(8A4;12D1)69Dn/J
001831   B6 x B6EiC3Sn a/A-T(8C3;16B5)164Dn/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
002016   B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ
000600   B6-Gpi1b x B6CBCa Aw-J/A-T(7;15)9H Gpi1a/J
000769   B6.C/(HZ18)By-at-44J/J
000203   B6.C3-Aiy/a/J
000017   B6.C3-Avy/J
001572   B6.C3-am-J/J
000628   B6.CE-A Amy1b Amy2a5b/J
001809   B6.Cg-Aw-J EdaTa-6J +/+ ArTfm/J
000552   B6.Cg-Aw-J EdaTa-6J Sxr
001730   B6.Cg-Aw-J EdaTa-6J Sxrb Hya-/J
000841   B6.Cg-Aw-J EdaTa-By/J
100409   B6129PF1/J-Aw-J/Aw
014608   B6;129S1-a Kitlsl-24J/GrsrJ
000231   B6;C3Fe a/a-Csf1op/J
004200   B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ
000785   B6;D2-a Ces1ce/EiJ
000505   B6C3 Aw-J/A-Bloc1s5mu/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
001750   B6C3Fe a/a-Eif3cXs-J/J
002807   B6C3Fe a/a-Meox2fla/J
000506   B6C3Fe a/a-Qkqk-v/J
000224   B6C3Fe a/a-Scyl1mdf/J
003020   B6C3Fe a/a-Zdhhc21dep/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
001815   B6C3Fe a/a-Col1a2oim/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
000624   B6C3Fe a/a-anx/J
008044   B6C3Fe a/a-bpck/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000065   B6C3Fe a/a-we Pax1un at/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
003301   B6C3FeF1 a/A-Eya1bor/J
001022   B6C3FeF1/J a/a
000314   B6CBACa Aw-J/A-EdaTa/J-XO
000501   B6CBACa Aw-J/A-Aifm1Hq/J
001046   B6CBACa Aw-J/A-Grid2Lc/J
000500   B6CBACa Aw-J/A-Gs/J
002703   B6CBACa Aw-J/A-Hydinhy3/J
000247   B6CBACa Aw-J/A-Kcnj6wv/J
000287   B6CBACa Aw-J/A-Plp1jp EdaTa/J
000515   B6CBACa Aw-J/A-SfnEr/J
000242   B6CBACa Aw-J/A-spc/J
000288   B6CBACa Aw-J/A-we a Mafbkr/J
001201   B6CBACaF1/J-Aw-J/A
006450   B6EiC3 a/A-Vss/GrsrJ
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
000557   B6EiC3-+ a/LnpUl A/J
000504   B6EiC3Sn a/A-Cacnb4lh/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001923   B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J
001875   B6EiC3SnF1/J
000638   C3FeB6 A/Aw-J-Sptbn4qv-J/J
000200   C3FeB6 A/Aw-J-Ankank/J
001203   C3FeB6F1/J A/Aw-J
000225   C3FeLe.B6 a/a-Ptpn6me/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
001886   C3HeB/FeJLe a/a-gnd/J
000338   C57BL/6J Aw-J-EdaTa-6J/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000569   C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
000051   C57BL/6J-Aw-J/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
000262   LS/LeJ
000283   LT.CAST-A/J
000265   MY/HuLeJ
000308   SSL/LeJ
001759   STOCK A Tyrc Sha/J
001427   STOCK Aw us/J
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Pmelsi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000281   STOCK a/a Tmem79ma Flgft/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b Ndc1sks/Tyrp1b +/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
001145   WSB/EiJ
View Strains carrying other alleles of a     (177 strains)

Additional Web Information

Comparison of widely used JAX® Mice for type 2 diabetes and obesity

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).
Diabetes Mellitus, Noninsulin-Dependent; NIDDM
Obesity
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Ay/a

        involves: KK
  • homeostasis/metabolism phenotype
  • abnormal lipid homeostasis
    • lipogenesis from acetate is elevated at 5 weeks of age, the enhanced activity is maintained until 16 weeks of age   (MGI Ref ID J:26460)
    • the acetate/glucose ratio is higher than control in young mice   (MGI Ref ID J:26460)
  • hyperglycemia
    • blood glucose levels increase with age in both sexes   (MGI Ref ID J:26460)
    • marked hyperglycemia (400-500 mg/dl) develops by 16 weeks of age   (MGI Ref ID J:26460)
  • impaired glucose tolerance   (MGI Ref ID J:26460)
  • increased circulating insulin level
    • markedly elevated plasma immunoreactive insulin (IRI) level increases with age   (MGI Ref ID J:26460)
  • increased urine glucose level
    • present at all ages tested (5, 10, 16 weeks) and in both sexes   (MGI Ref ID J:26460)
  • insulin resistance
    • insulin sensitivity is impaired at 10 weeks and lost by 16 weeks   (MGI Ref ID J:26460)
  • adipose tissue phenotype
  • increased total body fat amount
    • adipose tissue weight increases with age, reaching a maximum at 10 weeks of age   (MGI Ref ID J:26460)
  • growth/size/body phenotype
  • increased susceptibility to weight gain
    • greater body weight gain occurs in females as compared to black KK controls   (MGI Ref ID J:26460)
  • increased total body fat amount
    • adipose tissue weight increases with age, reaching a maximum at 10 weeks of age   (MGI Ref ID J:26460)
  • endocrine/exocrine gland phenotype
  • abnormal pancreatic islet morphology
    • islets are hypertrophic in 10-16 week old mice   (MGI Ref ID J:26460)
    • central cavity formation with occasional red blood cells is observed in islets   (MGI Ref ID J:26460)
    • degranulated pancreatic beta cells
      • beta cells are degranulated   (MGI Ref ID J:26460)
      • degranulated islets are infiltrated with fine glycogen granules   (MGI Ref ID J:26460)
  • renal/urinary system phenotype
  • abnormal renal glomerulus morphology
    • some glomeruli exhibit an accumulation of eosinophilic material in the outer parts of the capillary   (MGI Ref ID J:26460)
    • expanded mesangial matrix
      • mesangial matrix is thickened   (MGI Ref ID J:26460)
  • abnormal renal tubule morphology
    • basement membrane of tubules is thickened   (MGI Ref ID J:26460)
    • hyaline materials or hyaline cast is present in tubules   (MGI Ref ID J:26460)
    • dilated renal tubules   (MGI Ref ID J:26460)
  • increased renal glomerulus basement membrane thickness
    • basement membrane of Bowman's capsules is thickened   (MGI Ref ID J:26460)
  • increased urine glucose level
    • present at all ages tested (5, 10, 16 weeks) and in both sexes   (MGI Ref ID J:26460)
  • renal cast
    • hyaline materials or hyaline cast is present in tubules   (MGI Ref ID J:26460)

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Ay/A

        involves: C57BL/6
  • adipose tissue phenotype
  • increased brown adipose tissue amount
    • female mice have a 6-fold gain in weight of BAT compared to littermate controls   (MGI Ref ID J:131039)
  • increased gonadal fat pad weight
    • female mice have almost a 7-fold gain in weight of fat pad   (MGI Ref ID J:131039)
  • increased inguinal fat pad weight
    • female mice have a greater than 6-fold gain in weight of fat pad   (MGI Ref ID J:131039)
  • increased percent body fat
    • female mice have almost a 4-fold gain in percentage of body fat compared to littermate controls   (MGI Ref ID J:131039)
    • male mice have almost a 1.8-fold gain in percentage of body fat compared to littermate controls   (MGI Ref ID J:131039)
  • increased retroperitoneal fat pad weight
    • female mice have almost a 6-fold gain in weight of fat pad   (MGI Ref ID J:131039)
  • behavior/neurological phenotype
  • hypoactivity
    • the locomotor activity of mice is about half that of wild-type mice   (MGI Ref ID J:131039)
  • increased food intake
    • 18 week old mice eat about 1.4 times more food during a 7 day period compared to wild-type controls   (MGI Ref ID J:131039)
  • growth/size/body phenotype
  • increased body length
    • female but not male mice have a significant 5% increase in their body length   (MGI Ref ID J:131039)
  • increased percent body fat
    • female mice have almost a 4-fold gain in percentage of body fat compared to littermate controls   (MGI Ref ID J:131039)
    • male mice have almost a 1.8-fold gain in percentage of body fat compared to littermate controls   (MGI Ref ID J:131039)
  • increased susceptibility to weight gain
    • mice gain weight at a greater rate than littermate controls starting at six weeks of age   (MGI Ref ID J:131039)
  • obese
    • by 23 weeks of age, female mice have almost double the weight compared to their wild-type littermate controls   (MGI Ref ID J:131039)
  • homeostasis/metabolism phenotype
  • increased circulating leptin level
    • circulating levels of leptin are over 12-fold higher compared to littermate controls   (MGI Ref ID J:131039)
  • liver/biliary system phenotype
  • increased liver weight
    • female mice have almost a 2-fold gain in weight of the liver   (MGI Ref ID J:131039)
  • pigmentation phenotype
  • yellow coat color
    • mice have a yellow coat color   (MGI Ref ID J:131039)
  • integument phenotype
  • yellow coat color
    • mice have a yellow coat color   (MGI Ref ID J:131039)

Ay/Ay

        101-Ay
  • mortality/aging
  • embryonic lethality   (MGI Ref ID J:174504)
    • complete embryonic lethality at implantation
      • putative homozygous embryos appear as small masses of vacuolated cells in decidual crypts at the time normal embryos are implanting; the abnormal embryo is resorbed within 36 hours   (MGI Ref ID J:174504)
      • the genotype of the mother, with or without Ay, determines if a homozygous embryo dies at the initial stage of implantation or after the process begins   (MGI Ref ID J:174504)
  • other phenotype
  • maternal effect
    • introducing homozygous Ay embryos into the uterus of a wild-type mouse delays embryonic death until after implantation begins   (MGI Ref ID J:174504)
    • there are approximately twice the number of cells, development of a small ectoplacental cone and Reichert's membrane, and disintegration of the decidual epithelium characteristic of an advanced implantation site   (MGI Ref ID J:174504)

Ay/a

        B6.Cg-Ay/J
  • behavior/neurological phenotype
  • abnormal food intake
    • the stress of isolation, restraint, or ip injection inhibits feeding   (MGI Ref ID J:102986)
  • pigmentation phenotype
  • abnormal hair follicle melanogenesis
    • tyrosinase levels in hairbulb melanocytes ,as determined by 35S methionine incorporation and immunotitration, are reduced in comparison to a/a controls   (MGI Ref ID J:1295)
    • decreased tyrosinase suggests the production of predominantly phaeomelanin (yellow)   (MGI Ref ID J:1295)
  • integument phenotype
  • abnormal hair follicle melanogenesis
    • tyrosinase levels in hairbulb melanocytes ,as determined by 35S methionine incorporation and immunotitration, are reduced in comparison to a/a controls   (MGI Ref ID J:1295)
    • decreased tyrosinase suggests the production of predominantly phaeomelanin (yellow)   (MGI Ref ID J:1295)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Hyperglycemia
      more severe
Hyperinsulinemia
      more severe
Insulin Resistance
      more severe
Type 2 Diabetes (NIDDM)
      more severe

Ay related

Dermatology Research
Color and White Spotting Defects

Diabetes and Obesity Research
Obesity With Diabetes

Endocrine Deficiency Research
Adipose Defects
Adrenal Cortex Defects

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency Associated with Other Defects

Internal/Organ Research
Adipose Defects
Adrenal Cortex Defects

Reproductive Biology Research
Endocrine Deficiencies Affecting Gonads
Fertility Defects

Research Tools
Reproductive Biology Research

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ay
Allele Name agouti yellow
Allele Type Spontaneous
Common Name(s) A(y); Ay;
Strain of Originold mutant of the mouse fancy
Gene Symbol and Name a, nonagouti
Chromosome 2
Gene Common Name(s) AGSW; AGTI; AGTIL; ASP; As; SHEP9; agouti; agouti signal protein; agouti suppressor;
Molecular Note The Ay mutation appears to be a DNA structural alteration that disrupts a gene, hnRNP associated with lethal yellow (Raly), 5' to the agouti locus and places the agouti locus under the control of the Raly promotor. A report of recombination between Ay and the a and ax alleles suggests that Ay was a pseudoallele of the a locus on the proximal side. However, cloning of the agouti locus and molecular analysis of a showed that the coding region of the three allelesis identical. [MGI Ref ID J:12911] [MGI Ref ID J:17512] [MGI Ref ID J:18921] [MGI Ref ID J:8877]

Genotyping

Genotyping Information

Genotyping Protocols

Agouti - nonagouti, Separated PCR
Cdh23ahl, Pyrosequencing
Tyr c, Pyrosequencing
Tyr c-EP, End Point Analysis

Coat color is used to determine genotypes of our KK.Cg-Ay/J colony. Black (a/a homozygous) females are bred to yellow (Ay/a) males. All offspring with the Ay/a mutation and phenotype are yellow, the wild-type mice are black.

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Diani AR; Sawada GA; Hannah BA; Jodelis KS; Connell MA; Connell CL; Vidmar TJ; Wyse BM. 1987. Analysis of pancreatic islet cells and hormone content in the spontaneously diabetic KKAy mouse by morphometry, immunocytochemistry and radioimmunoassay. Virchows Arch A Pathol Anat Histopathol 412(1):53-61. [PubMed: 2446417]  [MGI Ref ID J:109946]

Iwatsuka H; Shino A; Suzuoki Z. 1970. General survey of diabetic features of yellow KK mice. Endocrinol Jpn 17(1):23-35. [PubMed: 5468422]  [MGI Ref ID J:26460]

Odaka H; Shino A; Ikeda H; Matsuo T. 1992. Antiobesity and antidiabetic actions of a new potent disaccharidase inhibitor in genetically obese-diabetic mice, KKA(y). J Nutr Sci Vitaminol (Tokyo) 38(1):27-37. [PubMed: 1629784]  [MGI Ref ID J:1263]

Reddi AS; Camerini-Davalos RA. 1988. Hereditary diabetes in the KK mouse: an overview. Adv Exp Med Biol 246:7-15. [PubMed: 3074669]  [MGI Ref ID J:109943]

Additional References

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Bultman SJ; Klebig ML; Michaud EJ; Sweet HO; Davisson MT; Woychik RP. 1994. Molecular analysis of reverse mutations from nonagouti (a) to black-and-tan (a(t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts. Genes Dev 8(4):481-90. [PubMed: 8125260]  [MGI Ref ID J:16984]

Bultman SJ; Michaud EJ; Woychik RP. 1992. Molecular characterization of the mouse agouti locus. Cell 71(7):1195-204. [PubMed: 1473152]  [MGI Ref ID J:3523]

Chen Y; Duhl DM; Barsh GS. 1996. Opposite orientations of an inverted duplication and allelic variation at the mouse agouti locus. Genetics 144(1):265-77. [PubMed: 8878692]  [MGI Ref ID J:35710]

Duhl DM; Stevens ME; Vrieling H; Saxon PJ; Miller MW; Epstein CJ; Barsh GS. 1994. Pleiotropic effects of the mouse lethal yellow (Ay) mutation explained by deletion of a maternally expressed gene and the simultaneous production of agouti fusion RNAs. Development 120(6):1695-708. [PubMed: 8050375]  [MGI Ref ID J:18921]

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Martin NM; Houston PA; Patterson M; Sajedi A; Carmignac DF; Ghatei MA; Bloom SR; Small CJ. 2006. Abnormalities of the somatotrophic axis in the obese agouti mouse. Int J Obes (Lond) 30(3):430-8. [PubMed: 16172617]  [MGI Ref ID J:151302]

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Pang Z; Nakagami H; Osako MK; Koriyama H; Nakagami F; Tomioka H; Shimamura M; Kurinami H; Takami Y; Morishita R; Rakugi H. 2014. Therapeutic vaccine against DPP4 improves glucose metabolism in mice. Proc Natl Acad Sci U S A 111(13):E1256-63. [PubMed: 24639549]  [MGI Ref ID J:207292]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX27

Colony Maintenance

Mating System+/+ sibling x Heterozygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a good breeder.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $107.50Female or MaleHeterozygous for Ay, Heterozygous for a  
4 weeks $107.50Female or MaleHeterozygous for Ay, Heterozygous for a  
5 weeks $107.50Female or MaleHeterozygous for Ay, Heterozygous for a  
6 weeks $110.80Female or MaleHeterozygous for Ay, Heterozygous for a  
7 weeks $114.10Female or MaleHeterozygous for Ay, Heterozygous for a  
8 weeks $114.10Female or MaleHeterozygous for Ay, Heterozygous for a  
9 weeks $120.70Female or MaleHeterozygous for Ay, Heterozygous for a  
10 weeks $124.00Female or MaleHeterozygous for Ay, Heterozygous for a  
11 weeks $127.30Female or MaleHeterozygous for Ay, Heterozygous for a  
12 weeks $130.60Female or MaleHeterozygous for Ay, Heterozygous for a  
3 weeks $70.00Female or MaleHomozygous for a  
4 weeks $70.00Female or MaleHomozygous for a  
5 weeks $70.00Female or MaleHomozygous for a  
6 weeks $70.00Female or MaleHomozygous for a  
7 weeks $70.00Female or MaleHomozygous for a  
8 weeks $70.00Female or MaleHomozygous for a  
9 weeks $70.00Female or MaleHomozygous for a  
10 weeks $70.00Female or MaleHomozygous for a  
11 weeks $70.00Female or MaleHomozygous for a  
12 weeks $70.00Female or MaleHomozygous for a  
Price per Pair (US dollars $)Pair Genotype
$180.80Homozygous for a x Heterozygous for Ay, Heterozygous for a  

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Supply Notes

  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $139.80Female or MaleHeterozygous for Ay, Heterozygous for a  
4 weeks $139.80Female or MaleHeterozygous for Ay, Heterozygous for a  
5 weeks $139.80Female or MaleHeterozygous for Ay, Heterozygous for a  
6 weeks $144.10Female or MaleHeterozygous for Ay, Heterozygous for a  
7 weeks $148.40Female or MaleHeterozygous for Ay, Heterozygous for a  
8 weeks $148.40Female or MaleHeterozygous for Ay, Heterozygous for a  
9 weeks $157.00Female or MaleHeterozygous for Ay, Heterozygous for a  
10 weeks $161.20Female or MaleHeterozygous for Ay, Heterozygous for a  
11 weeks $165.50Female or MaleHeterozygous for Ay, Heterozygous for a  
12 weeks $169.80Female or MaleHeterozygous for Ay, Heterozygous for a  
3 weeks $91.00Female or MaleHomozygous for a  
4 weeks $91.00Female or MaleHomozygous for a  
5 weeks $91.00Female or MaleHomozygous for a  
6 weeks $91.00Female or MaleHomozygous for a  
7 weeks $91.00Female or MaleHomozygous for a  
8 weeks $91.00Female or MaleHomozygous for a  
9 weeks $91.00Female or MaleHomozygous for a  
10 weeks $91.00Female or MaleHomozygous for a  
11 weeks $91.00Female or MaleHomozygous for a  
12 weeks $91.00Female or MaleHomozygous for a  
Price per Pair (US dollars $)Pair Genotype
$235.10Homozygous for a x Heterozygous for Ay, Heterozygous for a  

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Supply Notes

  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Control Information

  Control
   a/a from the colony
   See control note: Normal wildtype nonagouti (a/a) mice from the colony or KK/HlJ (Stock No. 002106) mice may be used as controls; the latter is only an approximate control whose degree of relationship to KK.Cg-Ay/J is uncertain (See Strain Development).
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Important Note

It has been reported that the KK strain is hemolytic complement deficient (Hc0), however, our strains have not been tested to confirm this allele. (Cinader B, et al.,2004, J Exp Med,120:897)

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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