Strain Name: |
STOCK Il2rgtm1Cgn/J |
|---|---|
Stock Number: |
002479 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
STOCK Il2rgtm1Cgn (Changed: 15-DEC-04
) |
| Genes & Alleles | Il2rg; Il2rgtm1Cgn; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Mutant Stock Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Targeted Mutation Species laboratory mouse Donating Investigator Klaus Rajewsky, Harvard Medical School Generation B6?+B6N4F3 Strain Description
Mice homozygous for the Il2rgtm1Cgn targeted mutation are viable and fertile. Mutant mice have hypoplastic thymuses with a 10-fold reduction in the absolute number of lymphocytes. They have a limited number of mature splenic B and T cells, lack NK cells and Peyer's patches, and development of gut-associated intraepithelial lymphocytes is diminished. In vitro studies show defects in NK activity, IL4-directed Ig class switching of thymocytes, and thymocyte mitogenic responses.
Related Disease (OMIM) Terms |
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Il2rgtm1Cgn | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, University of Cologne | ||
| Common Name(s) | IL-2Rgamma-; Il2rg-; cgamma-; gamma-; gammac-; | ||
| Mutation Made By | James DiSanto, University of Cologne | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Name | E14.1 | ||
| ES Cell Line Strain | 129P2/OlaHsd | ||
| Gene Symbol and Name | Il2rg, interleukin 2 receptor, gamma chain | ||
| Chromosome | X | ||
| Gene Common Name(s) | Ab2-183; CD132; IMD4; SCIDX; SCIDX1; [g]c; common cytokine receptor gamma chain; common gamma chain; gamma C receptor; gamma(c); | ||
| Molecular Note | Insertion of a neomycin resistance cassette flanked by lox P sites, followed by homologous recombination and cre-mediated deletion, resulted in the excision of exons 2 - 6 of the gene. These exons encode the extracellular and transmembrane domains of the protein. [MGI Ref ID J:22521] | ||
Control Information
| Allele | Control | |
|---|---|---|
| Il2rgtm1Cgn | 000664 C57BL/6J | (approximate) |
| Considerations for Choosing Controls | ||
Genotyping Protocols
Il2rgtm1Cgn
Related Strains
Strains carrying other alleles of Il2rg
003174 B6.129S4-Il2rgtm1Wjl/J 003169 C.129S4-Il2rgtm1Wjl/J 005557 NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ View Strains carrying other alleles of Il2rg (3 strains)
Research Applications
This mouse can be used to support research in many areas including:Il2rgtm1Cgn related
Cancer Research
Growth Factors/Receptors/Cytokines
Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines
Research Tools
Immunology and Inflammation Research (NK Cell Deficiency)
References
Selected Reference(s)
Additional ReferencesDiSanto JP; Muller W; Guy-Grand D; Fischer A; Rajewsky K. 1995. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc Natl Acad Sci U S A 92(2):377-81. [PubMed: 7831294] [MGI Ref ID J:22521]
Price and Supply Information
| Strain Name: | STOCK Il2rgtm1Cgn/J |
| Stock Number: | 002479 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below for Licensing and Use Restrictions |
| Control Information | View Control Information in Strain Details. |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
Effective September 26, 2007: License Requirements for Strains using Cre-lox Technology only apply in Canada, see Licenses for Strains using Cre-lox Technology.
For additional Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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