Strain Name:

C.129S4-Myod1tm1Jae/J

Stock Number:

002523

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain BALB/c
Donor Strain 129S4 via J1 ES cell line
 
Donating InvestigatorDr. Rudolf Jaenisch,   Whitehead Institute (MIT)

Appearance
albino
Related Genotype: A/A Tyrp1b/Tyrp1b Tyrc/Tyrc

Description
Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Histological examination of skeletal muscle reveals no morphological abnormalities. Northern analysis indicates that myogenic factor 5 mRNA levels are elevated in postnatal homozygous mutant mice. This mutant mouse strain may be useful in studies examining the factors involved in differentiation of skeletal muscle.

Control Information

  Control
   Wild-type from the colony
   000651 BALB/cJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Myod1
024475   B6;129-Myod1tm1.1(cre/ERT,TVA)Gcg/J
014140   FVB.Cg-Myod1tm2.1(icre)Glh/J
View Strains carrying other alleles of Myod1     (2 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Myod1tm1Jae/Myod1tm1Jae

        either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
  • normal phenotype
  • no abnormal phenotype detected   (MGI Ref ID J:3070)

Myod1tm1Jae/Myod1tm1Jae

        involves: 129S4/SvJae
  • muscle phenotype
  • abnormal myogenesis
    • skeletal myogenesis is not suppressed by genotoxins unlike in wild-type mice   (MGI Ref ID J:168843)
  • increased satellite cell number   (MGI Ref ID J:128921)
  • homeostasis/metabolism phenotype
  • decreased physiological sensitivity to xenobiotic
    • skeletal myogenesis is not suppressed by genotoxins unlike in wild-type mice   (MGI Ref ID J:168843)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Myod1tm1Jae related

Developmental Biology Research
Mesodermal Defects
      Myogenesis Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Myod1tm1Jae
Allele Name targeted mutation 1, Rudolf Jaenisch
Allele Type Targeted (knock-out)
Common Name(s) MyoD (-); MyoD-; MyoDml;
Mutation Made ByDr. Rudolf Jaenisch,   Whitehead Institute (MIT)
Strain of Origin129S4/SvJae
ES Cell Line NameJ1
ES Cell Line Strain129S4/SvJae
Gene Symbol and Name Myod1, myogenic differentiation 1
Chromosome 7
Gene Common Name(s) AI503393; MYF3; MYOD; Myod-1; PUM; bHLHc1; expressed sequence AI503393;
Molecular Note Replacement of the MyoD promoter, exon 1 and half of intron 1 with a neomycin cassette. [MGI Ref ID J:3070]

Genotyping

Genotyping Information

Genotyping Protocols

Myod1tm1Jae, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Rudnicki MA; Braun T; Hinuma S; Jaenisch R. 1992. Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development. Cell 71(3):383-90. [PubMed: 1330322]  [MGI Ref ID J:3070]

Additional References

Rudnicki MA; Schnegelsberg PN; Stead RH; Braun T; Arnold HH; Jaenisch R. 1993. MyoD or Myf-5 is required for the formation of skeletal muscle. Cell 75(7):1351-9. [PubMed: 8269513]  [MGI Ref ID J:16387]

Myod1tm1Jae related

Andrews JL; Zhang X; McCarthy JJ; McDearmon EL; Hornberger TA; Russell B; Campbell KS; Arbogast S; Reid MB; Walker JR; Hogenesch JB; Takahashi JS; Esser KA. 2010. CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function. Proc Natl Acad Sci U S A 107(44):19090-5. [PubMed: 20956306]  [MGI Ref ID J:166235]

Angka HE; Geddes AJ; Kablar B. 2008. Differential survival response of neurons to exogenous GDNF depends on the presence of skeletal muscle. Dev Dyn 237(11):3169-78. [PubMed: 18816441]  [MGI Ref ID J:143363]

Angka HE; Kablar B. 2007. Differential responses to the application of exogenous NT-3 are observed for subpopulations of motor and sensory neurons depending on the presence of skeletal muscle. Dev Dyn 236(5):1193-202. [PubMed: 17436272]  [MGI Ref ID J:121117]

Armand AS; Bourajjaj M; Martinez-Martinez S; el Azzouzi H; da Costa Martins PA; Hatzis P; Seidler T; Redondo JM; De Windt LJ. 2008. Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesis. J Biol Chem 283(43):29004-10. [PubMed: 18676376]  [MGI Ref ID J:142475]

Baguma-Nibasheka M; Angka HE; Inanlou MR; Kablar B. 2007. Microarray analysis of Myf5-/-:MyoD-/- hypoplastic mouse lungs reveals a profile of genes involved in pneumocyte differentiation. Histol Histopathol 22(5):483-95. [PubMed: 17330803]  [MGI Ref ID J:121955]

Biressi S; Messina G; Collombat P; Tagliafico E; Monteverde S; Benedetti L; Cusella De Angelis MG; Mansouri A; Ferrari S; Tajbakhsh S; Broccoli V; Cossu G. 2008. The homeobox gene Arx is a novel positive regulator of embryonic myogenesis. Cell Death Differ 15(1):94-104. [PubMed: 17932502]  [MGI Ref ID J:141473]

Brack AS; Bildsoe H; Hughes SM. 2005. Evidence that satellite cell decrement contributes to preferential decline in nuclear number from large fibres during murine age-related muscle atrophy. J Cell Sci 118(Pt 20):4813-21. [PubMed: 16219688]  [MGI Ref ID J:102185]

Brent AE; Braun T; Tabin CJ. 2005. Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development. Development 132(3):515-28. [PubMed: 15634692]  [MGI Ref ID J:95359]

Brohl D; Vasyutina E; Czajkowski MT; Griger J; Rassek C; Rahn HP; Purfurst B; Wende H; Birchmeier C. 2012. Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on Notch signals. Dev Cell 23(3):469-81. [PubMed: 22940113]  [MGI Ref ID J:188916]

Charge SB; Brack AS; Bayol SA; Hughes SM. 2008. MyoD- and nerve-dependent maintenance of MyoD expression in mature muscle fibres acts through the DRR/PRR element. BMC Dev Biol 8:5. [PubMed: 18215268]  [MGI Ref ID J:135236]

Daou N; Lecolle S; Lefebvre S; della Gaspera B; Charbonnier F; Chanoine C; Armand AS. 2013. A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis. Development 140(24):4914-25. [PubMed: 24301466]  [MGI Ref ID J:206594]

Dey J; Dubuc AM; Pedro KD; Thirstrup D; Mecham B; Northcott PA; Wu X; Shih D; Tapscott SJ; LeBlanc M; Taylor MD; Olson JM. 2013. MyoD is a tumor suppressor gene in medulloblastoma. Cancer Res 73(22):6828-37. [PubMed: 24092238]  [MGI Ref ID J:205413]

Floss T; Arnold HH; Braun T. 1997. A role for FGF-6 in skeletal muscle regeneration. Genes Dev 11(16):2040-51. [PubMed: 9284044]  [MGI Ref ID J:42574]

Garry DJ; Yang Q; Bassel-Duby R; Williams RS. 1997. Persistent expression of MNF identifies myogenic stem cells in postnatal muscles. Dev Biol 188(2):280-94. [PubMed: 9268575]  [MGI Ref ID J:42845]

Gayraud-Morel B; Chretien F; Flamant P; Gomes D; Zammit PS; Tajbakhsh S. 2007. A role for the myogenic determination gene Myf5 in adult regenerative myogenesis. Dev Biol 312(1):13-28. [PubMed: 17961534]  [MGI Ref ID J:128921]

Gomez C; David V; Peet NM; Vico L; Chenu C; Malaval L; Skerry TM. 2007. Absence of mechanical loading in utero influences bone mass and architecture but not innervation in Myod-Myf5-deficient mice. J Anat 210(3):259-71. [PubMed: 17331176]  [MGI Ref ID J:124478]

Gunther S; Kim J; Kostin S; Lepper C; Fan CM; Braun T. 2013. Myf5-positive satellite cells contribute to pax7-dependent long-term maintenance of adult muscle stem cells. Cell Stem Cell 13(5):590-601. [PubMed: 23933088]  [MGI Ref ID J:202693]

Hirai H; Verma M; Watanabe S; Tastad C; Asakura Y; Asakura A. 2010. MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3. J Cell Biol 191(2):347-65. [PubMed: 20956382]  [MGI Ref ID J:165481]

Hughes SM; Koishi K; Rudnicki M; Maggs AM. 1997. MyoD protein is differentially accumulated in fast and slow skeletal muscle fibres and required for normal fibre type balance in rodents. Mech Dev 61(1-2):151-63. [PubMed: 9076685]  [MGI Ref ID J:38634]

Huijbregts J; White JD; Grounds MD. 2001. The absence of MyoD in regenerating skeletal muscle affects the expression pattern of basement membrane, interstitial matrix and integrin molecules that is consistent with delayed myotube formation. Acta Histochem 103(4):379-96. [PubMed: 11700944]  [MGI Ref ID J:102568]

Inanlou MR; Dhillon GS; Belliveau AC; Reid GA; Ying C; Rudnicki MA; Kablar B. 2003. A significant reduction of the diaphragm in mdx:MyoD-/-(9th) embryos suggests a role for MyoD in the diaphragm development. Dev Biol 261(2):324-36. [PubMed: 14499644]  [MGI Ref ID J:85548]

Inanlou MR; Kablar B. 2003. Abnormal development of the diaphragm in mdx:MyoD-/-(9th) embryos leads to pulmonary hypoplasia. Int J Dev Biol 47(5):363-71. [PubMed: 12895031]  [MGI Ref ID J:100052]

Inanlou MR; Kablar B. 2005. Contractile activity of skeletal musculature involved in breathing is essential for normal lung cell differentiation, as revealed in Myf5-/-:MyoD-/- embryos. Dev Dyn 233(3):772-782. [PubMed: 15844178]  [MGI Ref ID J:98811]

Innocenzi A; Latella L; Messina G; Simonatto M; Marullo F; Berghella L; Poizat C; Shu CW; Wang JY; Puri PL; Cossu G. 2011. An evolutionarily acquired genotoxic response discriminates MyoD from Myf5, and differentially regulates hypaxial and epaxial myogenesis. EMBO Rep 12(2):164-71. [PubMed: 21212806]  [MGI Ref ID J:168843]

Kablar B. 2003. Determination of retinal cell fates is affected in the absence of extraocular striated muscles. Dev Dyn 226(3):478-90. [PubMed: 12619134]  [MGI Ref ID J:82209]

Kablar B; Asakura A; Krastel K; Ying C; May LL; Goldhamer DJ ; Rudnicki MA. 1998. MyoD and Myf-5 define the specification of musculature of distinct embryonic origin. Biochem Cell Biol 76(6):1079-91. [PubMed: 10392718]  [MGI Ref ID J:55565]

Kablar B; Belliveau AC. 2005. Presence of neurotrophic factors in skeletal muscle correlates with survival of spinal cord motor neurons. Dev Dyn 234(3):659-69. [PubMed: 16193506]  [MGI Ref ID J:102289]

Kablar B; Krastel K; Tajbakhsh S; Rudnicki MA. 2003. Myf5 and MyoD activation define independent myogenic compartments during embryonic development. Dev Biol 258(2):307-18. [PubMed: 12798290]  [MGI Ref ID J:83932]

Kablar B; Krastel K; Ying C; Asakura A; Tapscott SJ; Rudnicki MA. 1997. MyoD and Myf-5 differentially regulate the development of limb versus trunk skeletal muscle. Development 124(23):4729-38. [PubMed: 9428409]  [MGI Ref ID J:45349]

Kablar B; Rudnicki MA. 1999. Development in the absence of skeletal muscle results in the sequential ablation of motor neurons from the spinal cord to the brain. Dev Biol 208(1):93-109. [PubMed: 10075844]  [MGI Ref ID J:54064]

Kablar B; Rudnicki MA. 2002. Information provided by the skeletal muscle and associated neurons is necessary for proper brain development. Int J Dev Neurosci 20(7):573-84. [PubMed: 12485625]  [MGI Ref ID J:100037]

Kablar B; Tajbakhsh S; Rudnicki MA. 2000. Transdifferentiation of esophageal smooth to skeletal muscle is myogenic bHLH factor-dependent. Development 127(8):1627-39. [PubMed: 10725239]  [MGI Ref ID J:60987]

Kahn J; Shwartz Y; Blitz E; Krief S; Sharir A; Breitel DA; Rattenbach R; Relaix F; Maire P; Rountree RB; Kingsley DM; Zelzer E. 2009. Muscle contraction is necessary to maintain joint progenitor cell fate. Dev Cell 16(5):734-43. [PubMed: 19460349]  [MGI Ref ID J:148688]

Kassar-Duchossoy L; Gayraud-Morel B; Gomes D; Rocancourt D; Buckingham M; Shinin V; Tajbakhsh S. 2004. Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice. Nature 431(7007):466-71. [PubMed: 15386014]  [MGI Ref ID J:92799]

Kassar-Duchossoy L; Giacone E; Gayraud-Morel B; Jory A; Gomes D; Tajbakhsh S. 2005. Pax3/Pax7 mark a novel population of primitive myogenic cells during development. Genes Dev 19(12):1426-31. [PubMed: 15964993]  [MGI Ref ID J:98918]

Kirillova I; Gussoni E; Goldhamer DJ; Yablonka-Reuveni Z. 2007. Myogenic reprogramming of retina-derived cells following their spontaneous fusion with myotubes. Dev Biol 311(2):449-63. [PubMed: 17919536]  [MGI Ref ID J:193808]

Kolodziejczyk SM; Walsh GS; Balazsi K; Seale P; Sandoz J; Hierlihy AM; Rudnicki MA; Chamberlain JS; Miller FD; Megeney LA. 2001. Activation of JNK1 contributes to dystrophic muscle pathogenesis. Curr Biol 11(16):1278-82. [PubMed: 11525743]  [MGI Ref ID J:71463]

Komaki M; Asakura A; Rudnicki MA; Sodek J; Cheifetz S. 2004. MyoD enhances BMP7-induced osteogenic differentiation of myogenic cell cultures. J Cell Sci 117(Pt 8):1457-68. [PubMed: 15020674]  [MGI Ref ID J:88938]

Megeney LA; Kablar B; Garrett K; Anderson JE; Rudnicki MA. 1996. MyoD is required for myogenic stem cell function in adult skeletal muscle. Genes Dev 10(10):1173-83. [PubMed: 8675005]  [MGI Ref ID J:33260]

Megeney LA; Kablar B; Perry RL; Ying C; May L; Rudnicki MA. 1999. Severe cardiomyopathy in mice lacking dystrophin and MyoD. Proc Natl Acad Sci U S A 96(1):220-5. [PubMed: 9874799]  [MGI Ref ID J:52248]

Parker SB; Eichele G; Zhang P; Rawls A; Sands AT; Bradley A; Olson EN; Harper JW; Elledge SJ. 1995. p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells [see comments] Science 267(5200):1024-7. [PubMed: 7863329]  [MGI Ref ID J:37752]

Rawls A; Morris JH; Rudnicki M; Braun T; Arnold HH; Klein WH; Olson EN. 1995. Myogenin's functions do not overlap with those of MyoD or Myf-5 during mouse embryogenesis. Dev Biol 172(1):37-50. [PubMed: 7589813]  [MGI Ref ID J:29672]

Rawls A; Valdez MR; Zhang W; Richardson J; Klein WH; Olson EN. 1998. Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice. Development 125(13):2349-58. [PubMed: 9609818]  [MGI Ref ID J:48809]

Reddy T; Kablar B. 2004. Evidence for the involvement of neurotrophins in muscle transdifferentiation and acetylcholine receptor transformation in the esophagus of Myf5(-/-):MyoD(-/-) and NT-3(-/-) embryos. Dev Dyn 231(4):683-92. [PubMed: 15497153]  [MGI Ref ID J:93814]

Rudnicki MA; Schnegelsberg PN; Stead RH; Braun T; Arnold HH; Jaenisch R. 1993. MyoD or Myf-5 is required for the formation of skeletal muscle. Cell 75(7):1351-9. [PubMed: 8269513]  [MGI Ref ID J:16387]

Sambasivan R; Gayraud-Morel B; Dumas G; Cimper C; Paisant S; Kelly R; Tajbakhsh S. 2009. Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates. Dev Cell 16(6):810-21. [PubMed: 19531352]  [MGI Ref ID J:150130]

Staib JL; Swoap SJ; Powers SK. 2002. Diaphragm contractile dysfunction in MyoD gene-inactivated mice. Am J Physiol Regul Integr Comp Physiol 283(3):R583-90. [PubMed: 12184991]  [MGI Ref ID J:113546]

Starkey JD; Yamamoto M; Yamamoto S; Goldhamer DJ. 2011. Skeletal muscle satellite cells are committed to myogenesis and do not spontaneously adopt nonmyogenic fates. J Histochem Cytochem 59(1):33-46. [PubMed: 21339173]  [MGI Ref ID J:169754]

Stephens HE; Belliveau AC; Gupta JS; Mirkovic S; Kablar B. 2005. The role of neurotrophins in the maintenance of the spinal cord motor neurons and the dorsal root ganglia proprioceptive sensory neurons. Int J Dev Neurosci 23(7):613-20. [PubMed: 16183241]  [MGI Ref ID J:106341]

Tallquist MD; Weismann KE; Hellstrom M; Soriano P. 2000. Early myotome specification regulates PDGFA expression and axial skeleton development Development 127(23):5059-70. [PubMed: 11060232]  [MGI Ref ID J:65301]

Tiidus PM; Bombardier E; Xeni J; Bestic NM; Vandenboom R; Rudnicki MA; Houston ME. 1996. Elevated catalase activity in red and white muscles of MyoD gene-inactivated mice. Biochem Mol Biol Int 39(5):1029-35. [PubMed: 8866021]  [MGI Ref ID J:35699]

Valdez MR; Richardson JA; Klein WH; Olson EN. 2000. Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4. Dev Biol 219(2):287-98. [PubMed: 10694423]  [MGI Ref ID J:61155]

Vincent SD; Mayeuf A; Niro C; Saitou M; Buckingham M. 2012. Non Conservation of Function for the Evolutionarily Conserved Prdm1 Protein in the Control of the Slow Twitch Myogenic Program in the Mouse Embryo. Mol Biol Evol :. [PubMed: 22522309]  [MGI Ref ID J:186268]

Wang Y; Jaenisch R. 1997. Myogenin can substitute for Myf5 in promoting myogenesis but less efficiently. Development 124(13):2507-13. [PubMed: 9216993]  [MGI Ref ID J:41685]

Wang ZZ; Washabaugh CH; Yao Y; Wang JM; Zhang L; Ontell MP; Watkins SC; Rudnicki MA; Ontell M. 2003. Aberrant development of motor axons and neuromuscular synapses in MyoD-null mice. J Neurosci 23(12):5161-9. [PubMed: 12832540]  [MGI Ref ID J:84331]

Watanabe S; Hirai H; Asakura Y; Tastad C; Verma M; Keller C; Dutton JR; Asakura A. 2011. MyoD gene suppression by Oct4 is required for reprogramming in myoblasts to produce induced pluripotent stem cells. Stem Cells 29(3):505-16. [PubMed: 21425413]  [MGI Ref ID J:175957]

White JD; Scaffidi A; Davies M; McGeachie J; Rudnicki MA; Grounds MD. 2000. Myotube formation is delayed but not prevented in MyoD-deficient skeletal muscle: studies in regenerating whole muscle grafts of adult mice. J Histochem Cytochem 48(11):1531-44. [PubMed: 11036096]  [MGI Ref ID J:120027]

Yablonka-Reuveni Z; Rudnicki MA; Rivera AJ; Primig M; Anderson JE; Natanson P. 1999. The transition from proliferation to differentiation is delayed in satellite cells from mice lacking MyoD. Dev Biol 210(2):440-55. [PubMed: 10357902]  [MGI Ref ID J:56462]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3175.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1600.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4127.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2080.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Wild-type from the colony
   000651 BALB/cJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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