Strain Name:

B6;129S2-Ccnd1tm1Wbg/J

Stock Number:

002537

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Availability:

Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
 
Donating Investigator Robert Weinberg,   Whitehead Institute (MIT)

Appearance
white-bellied agouti
Related Genotype: Aw/?

black
Related Genotype: a/a

Description
Mice homozygous for the targeted mutation develop to term but show growth retardation that is most pronounced by three weeks of age. The majority of mutant mice die early in life, often within the first month. Survivors continue to show lower than average weight and increased mortality. Mammary gland epithelial duct development is normal in virgin mutant mice. Mutant females that survive to adulthood are fertile, but mammary glands of pregnant mice show a dramatic impairment in the expansion of alveolar lobes and mice are unable to lactate. Steroid hormone levels are normal, and there is no apparent defect in estrogen receptor number, suggesting that cyclin D1 deficiency has an effect on the target tissue directly. Mutant mice demonstrate a neurological abnormality evidenced by limb retraction when lifted by their tails. The most severely affected animals remain in a clasped, flexed position for a few seconds after they have been returned to their cage. Retinal abnormalities include a dramatic reduction in cell numbers in all cell layers of the neural retina. This is due to the severely reduced ability of mutant retinal cell precursors to proliferate during embryonic development. The thickness of the inner plexiform layer is also reduced. The cells within the retina respond properly to light.

Development
A 3700 bp EagI fragment of the mouse cyclin D1 gene, (5' to the first coding exon) was used in the targeting vector, and electoporated into D3 ES cells. Cyclin D1 heterozygous ES cells ere injected into C57BL/6 embryos, and the resulting chimeras were bred to B6 mice. The resulting cyclin D1 heterozygotes were bred to produce homozygous mice. The targeting vector deletes coding portions of exons I-III of the cyclin D1 gene and replaces them with the neomycin resistance gene.

Control Information

  Control
   Wild-type from the colony
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Ccnd1tm1Wbg allele
002935   FVB.129S2(B6)-Ccnd1tm1Wbg/J
View Strains carrying   Ccnd1tm1Wbg     (1 strain)

Strains carrying other alleles of Ccnd1
005143   C3.B6-Tg(Fabp1-Ccnd1)4Rdb/J
004834   C57BL/6-Tg(Fabp1-Ccnd1)4Rdb/J
View Strains carrying other alleles of Ccnd1     (2 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Myeloma, Multiple   (CCND1)
Von Hippel-Lindau Syndrome; VHL   (CCND1)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Ccnd1tm1Wbg/Ccnd1tm1Wbg

        involves: 129S2/SvPas * C57BL/6
  • reproductive system phenotype
  • abnormal mammary gland growth during pregnancy
    • mammary epithelia transplanted into wild-type hosts fails to undergo lobuloalveolar development during pregnancy   (MGI Ref ID J:55690)
  • vision/eye phenotype
  • abnormal eye electrophysiology
    • have an essentially flat electroretinographic readout following light exposure   (MGI Ref ID J:55690)
  • retina hypoplasia
    • hypoplastic and disorganized retina   (MGI Ref ID J:55690)
  • behavior/neurological phenotype
  • limb grasping   (MGI Ref ID J:55690)
  • growth/size/body phenotype
  • postnatal growth retardation
    • about 2 fold smaller than wild-type littermates at 3 weeks of age   (MGI Ref ID J:55690)
  • endocrine/exocrine gland phenotype
  • abnormal mammary gland growth during pregnancy
    • mammary epithelia transplanted into wild-type hosts fails to undergo lobuloalveolar development during pregnancy   (MGI Ref ID J:55690)
  • integument phenotype
  • abnormal mammary gland growth during pregnancy
    • mammary epithelia transplanted into wild-type hosts fails to undergo lobuloalveolar development during pregnancy   (MGI Ref ID J:55690)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Ccnd1tm1Wbg/Ccnd1tm1Wbg

        involves: 129S2/SvPas
  • mortality/aging
  • partial postnatal lethality
    • about 25% die during the first month of life   (MGI Ref ID J:105045)
  • growth/size/body phenotype
  • postnatal growth retardation   (MGI Ref ID J:105045)
    • by the third week of life, mutants were approximately 1/2 of the size of wildtype   (MGI Ref ID J:95994)
  • vision/eye phenotype
  • abnormal eye electrophysiology
    • reduced amplitudes of the a- and b-waves in retinas in response to a pulse of light, with a-waves corresponding to 15% of those seen in wildtype   (MGI Ref ID J:95994)
    • retinas respond to light with electroretinographic potentials corresponding to about 10% of those seen in wild-type   (MGI Ref ID J:105045)
  • retina hypoplasia   (MGI Ref ID J:105045)
    • all cell layers (outer nuclear, inner nuclear, and ganglion cell layers) of the retina were hypoplastic   (MGI Ref ID J:95994)
  • endocrine/exocrine gland phenotype
  • abnormal lactation
    • unable to breast-feed pups due to abnormal mammary tissue development   (MGI Ref ID J:95994)
  • abnormal mammary gland growth during pregnancy
    • underdeveloped mammary epithelial tree at the end of pregnancy   (MGI Ref ID J:95994)
  • reproductive system phenotype
  • abnormal mammary gland growth during pregnancy
    • underdeveloped mammary epithelial tree at the end of pregnancy   (MGI Ref ID J:95994)
  • behavior/neurological phenotype
  • limb grasping
    • when lifted by tails, responded by rapidly retracting their limbs   (MGI Ref ID J:95994)
  • integument phenotype
  • abnormal lactation
    • unable to breast-feed pups due to abnormal mammary tissue development   (MGI Ref ID J:95994)
  • abnormal mammary gland growth during pregnancy
    • underdeveloped mammary epithelial tree at the end of pregnancy   (MGI Ref ID J:95994)

Ccnd1tm1Wbg/Ccnd1tm1Wbg

        involves: 129S2/SvPas * CD-1
  • digestive/alimentary phenotype
  • abnormal digestive system physiology
    • administration of recombinant EPHB2-Fc fusion protein does not reduce proliferation in either the colon or small intestine as it does in wild-type mice   (MGI Ref ID J:157019)

Ccnd1tm1Wbg/Ccnd1tm1Wbg

        involves: 129S2/SvPas * FVB/N
  • behavior/neurological phenotype
  • abnormal nursing
    • mice exhibit normal nursing behavior and fail to rear offspring   (MGI Ref ID J:178842)
  • endocrine/exocrine gland phenotype
  • *normal* endocrine/exocrine gland phenotype
    • mice exhibit normal mammary gland secretory alveoli proliferation and differentiation   (MGI Ref ID J:178842)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Ccnd1tm1Wbg related

Cancer Research
Genes Regulating Growth and Proliferation
Other

Cell Biology Research
Cell Cycle Regulation
Genes Regulating Growth and Proliferation

Developmental Biology Research
Eye Defects
Growth Defects
Postnatal Lethality

Sensorineural Research
Eye Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ccnd1tm1Wbg
Allele Name targeted mutation 1, Robert A Weinberg
Allele Type Targeted (Null/Knockout)
Common Name(s) CD1-; cyclin D1-;
Mutation Made By Robert Weinberg,   Massachusetts Institute of Technology
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Ccnd1, cyclin D1
Chromosome 7
Gene Common Name(s) AI327039; BCL1; CycD1; Cyl-1; D11S287E; PRAD1; U21B31; bcl-1; cD1; expressed sequence AI327039;
Molecular Note A genomic fragment containing part of exon 1, exon 2 and exon 3 was replaced with a neomycin selection cassette. The deleted sequences encode the cyclin box domain thought to be required for protein activity. Western blot analysis on embryonic fibroblasts derived from homozygous mice confirmed that no stable protein was made from this allele. [MGI Ref ID J:28419]

Genotyping

Genotyping Information

Genotyping Protocols

Ccndtm1Wbg, Separated PCR
Ccndtm1Wbg, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Sicinski P; Donaher JL; Parker SB; Li T; Fazeli A; Gardner H; Haslam SZ; Bronson RT; Elledge SJ; Weinberg RA. 1995. Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 82(4):621-30. [PubMed: 7664341]  [MGI Ref ID J:28419]

Additional References

Bagui TK; Jackson RJ; Agrawal D; Pledger WJ. 2000. Analysis of cyclin D3-cdk4 complexes in fibroblasts expressing and lacking p27(kip1) and p21(cip1) Mol Cell Biol 20(23):8748-57. [PubMed: 11073976]  [MGI Ref ID J:65789]

Bowe DB; Kenney NJ; Adereth Y; Maroulakou IG. 2002. Suppression of Neu-induced mammary tumor growth in cyclin D1 deficient mice is compensated for by cyclin E. Oncogene 21(2):291-8. [PubMed: 11803472]  [MGI Ref ID J:74381]

Ccnd1tm1Wbg related

Asher JM; O'Leary KA; Rugowski DE; Arendt LM; Schuler LA. 2012. Prolactin promotes mammary pathogenesis independently from cyclin d1. Am J Pathol 181(1):294-302. [PubMed: 22658484]  [MGI Ref ID J:185515]

Aupperlee MD; Drolet AA; Durairaj S; Wang W; Schwartz RC; Haslam SZ. 2009. Strain-specific differences in the mechanisms of progesterone regulation of murine mammary gland development. Endocrinology 150(3):1485-94. [PubMed: 18988671]  [MGI Ref ID J:158091]

Beleut M; Rajaram RD; Caikovski M; Ayyanan A; Germano D; Choi Y; Schneider P; Brisken C. 2010. Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. Proc Natl Acad Sci U S A 107(7):2989-94. [PubMed: 20133621]  [MGI Ref ID J:157571]

Carthon BC; Neumann CA; Das M; Pawlyk B; Li T; Geng Y; Sicinski P. 2005. Genetic replacement of cyclin D1 function in mouse development by cyclin D2. Mol Cell Biol 25(3):1081-8. [PubMed: 15657434]  [MGI Ref ID J:95994]

Casimiro MC; Crosariol M; Loro E; Ertel A; Yu Z; Dampier W; Saria EA; Papanikolaou A; Stanek TJ; Li Z; Wang C; Fortina P; Addya S; Tozeren A; Knudsen ES; Arnold A; Pestell RG. 2012. ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice. J Clin Invest 122(3):833-43. [PubMed: 22307325]  [MGI Ref ID J:184487]

Chen B; Pollard JW. 2003. Cyclin D2 compensates for the loss of cyclin D1 in estrogen-induced mouse uterine epithelial cell proliferation. Mol Endocrinol 17(7):1368-81. [PubMed: 12649329]  [MGI Ref ID J:84144]

Chen Z; Duan RS; Zhu Y; Folkesson R; Albanese C; Winblad B; Zhu J. 2005. Increased cyclin E expression may obviate the role of cyclin D1 during brain development in cyclin D1 knockout mice. J Neurochem 92(5):1281-4. [PubMed: 15715677]  [MGI Ref ID J:96799]

Choi YJ; Li X; Hydbring P; Sanda T; Stefano J; Christie AL; Signoretti S; Look AT; Kung AL; von Boehmer H; Sicinski P. 2012. The requirement for cyclin D function in tumor maintenance. Cancer Cell 22(4):438-51. [PubMed: 23079655]  [MGI Ref ID J:192032]

Ciemerych MA; Kenney AM; Sicinska E; Kalaszczynska I; Bronson RT; Rowitch DH; Gardner H; Sicinski P. 2002. Development of mice expressing a single D-type cyclin. Genes Dev 16(24):3277-89. [PubMed: 12502747]  [MGI Ref ID J:80994]

Ciemerych MA; Yu Q; Szczepanska K; Sicinski P. 2008. CDK4 activity in mouse embryos expressing a single D-type cyclin. Int J Dev Biol 52(2-3):299-305. [PubMed: 18311721]  [MGI Ref ID J:131845]

Ciznadija D; Liu Y; Pyonteck SM; Holland EC; Koff A. 2011. Cyclin d1 and cdk4 mediate development of neurologically destructive oligodendroglioma. Cancer Res 71(19):6174-83. [PubMed: 21844184]  [MGI Ref ID J:176420]

Cooper AB; Sawai CM; Sicinska E; Powers SE; Sicinski P; Clark MR; Aifantis I. 2006. A unique function for cyclin D3 in early B cell development. Nat Immunol 7(5):489-97. [PubMed: 16582912]  [MGI Ref ID J:112393]

Das G; Choi Y; Sicinski P; Levine EM. 2009. Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells. Neural Dev 4:15. [PubMed: 19416500]  [MGI Ref ID J:160729]

Das G; Clark AM; Levine EM. 2012. Cyclin D1 inactivation extends proliferation and alters histogenesis in the postnatal mouse retina. Dev Dyn 241(5):941-52. [PubMed: 22434780]  [MGI Ref ID J:183870]

Frech MS; Torre KM; Robinson GW; Furth PA. 2008. Loss of cyclin D1 in concert with deregulated estrogen receptor alpha expression induces DNA damage response activation and interrupts mammary gland morphogenesis. Oncogene 27(22):3186-93. [PubMed: 18071314]  [MGI Ref ID J:135609]

Fu M; Rao M; Bouras T; Wang C; Wu K; Zhang X; Li Z; Yao TP; Pestell RG. 2005. Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. J Biol Chem 280(17):16934-41. [PubMed: 15713663]  [MGI Ref ID J:98783]

Genander M; Halford MM; Xu NJ; Eriksson M; Yu Z; Qiu Z; Martling A; Greicius G; Thakar S; Catchpole T; Chumley MJ; Zdunek S; Wang C; Holm T; Goff SP; Pettersson S; Pestell RG; Henkemeyer M; Frisen J. 2009. Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. Cell 139(4):679-92. [PubMed: 19914164]  [MGI Ref ID J:157019]

Geng Y; Whoriskey W; Park MY; Bronson RT; Medema RH; Li T; Weinberg RA; Sicinski P. 1999. Rescue of cyclin D1 deficiency by knockin cyclin E. Cell 97(6):767-77. [PubMed: 10380928]  [MGI Ref ID J:55690]

Geng Y; Yu Q; Sicinska E; Das M; Bronson RT; Sicinski P. 2001. Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice. Proc Natl Acad Sci U S A 98(1):194-9. [PubMed: 11134518]  [MGI Ref ID J:66707]

Glickstein SB; Alexander S; Ross ME. 2007. Differences in cyclin D2 and D1 protein expression distinguish forebrain progenitor subsets. Cereb Cortex 17(3):632-42. [PubMed: 16627858]  [MGI Ref ID J:174119]

Glickstein SB; Monaghan JA; Koeller HB; Jones TK; Ross ME. 2009. Cyclin D2 is critical for intermediate progenitor cell proliferation in the embryonic cortex. J Neurosci 29(30):9614-24. [PubMed: 19641124]  [MGI Ref ID J:151321]

Glickstein SB; Moore H; Slowinska B; Racchumi J; Suh M; Chuhma N; Ross ME. 2007. Selective cortical interneuron and GABA deficits in cyclin D2-null mice. Development 134(22):4083-93. [PubMed: 17965053]  [MGI Ref ID J:127074]

Hulit J; Wang C; Li Z; Albanese C; Rao M; Di Vizio D; Shah S; Byers SW; Mahmood R; Augenlicht LH; Russell R; Pestell RG. 2004. Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. (Erratum: v 25(1):523) Mol Cell Biol 24(17):7598-611. [PubMed: 15314168]  [MGI Ref ID J:92787]

Kim HA; Pomeroy SL; Whoriskey W; Pawlitzky I; Benowitz LI; Sicinski P; Stiles CD; Roberts TM. 2000. A developmentally regulated switch directs regenerative growth of Schwann cells through cyclin D1. Neuron 26(2):405-16. [PubMed: 10839359]  [MGI Ref ID J:62564]

Kim NS; Kim HJ; Koo BK; Kwon MC; Kim YW; Cho Y; Yokota Y; Penninger JM; Kong YY. 2006. Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2. Mol Cell Biol 26(3):1002-13. [PubMed: 16428453]  [MGI Ref ID J:105570]

Kowalczyk A; Filipkowski RK; Rylski M; Wilczynski GM; Konopacki FA; Jaworski J; Ciemerych MA; Sicinski P; Kaczmarek L. 2004. The critical role of cyclin D2 in adult neurogenesis. J Cell Biol 167(2):209-13. [PubMed: 15504908]  [MGI Ref ID J:93310]

Kushner JA; Ciemerych MA; Sicinska E; Wartschow LM; Teta M; Long SY; Sicinski P; White MF. 2005. Cyclins D2 and D1 Are Essential for Postnatal Pancreatic {beta}-Cell Growth. Mol Cell Biol 25(9):3752-62. [PubMed: 15831479]  [MGI Ref ID J:97628]

Landis MW; Pawlyk BS; Li T; Sicinski P; Hinds PW. 2006. Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell 9(1):13-22. [PubMed: 16413468]  [MGI Ref ID J:105045]

Lee EK; Lian Z; D'Andrea K; Letrero R; Sheng W; Liu S; Diehl JN; Pytel D; Barbash O; Schuchter L; Amaravaradi R; Xu X; Herlyn M; Nathanson KL; Diehl JA. 2013. The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma. Mol Cell Biol 33(22):4422-33. [PubMed: 24019069]  [MGI Ref ID J:206100]

Li Z; Jiao X; Wang C; Ju X; Lu Y; Yuan L; Lisanti MP; Katiyar S; Pestell RG. 2006. Cyclin D1 induction of cellular migration requires p27(KIP1). Cancer Res 66(20):9986-94. [PubMed: 17047061]  [MGI Ref ID J:114959]

Li Z; Wang C; Jiao X; Lu Y; Fu M; Quong AA; Dye C; Yang J; Dai M; Ju X; Zhang X; Li A; Burbelo P; Stanley ER; Pestell RG. 2006. Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling. Mol Cell Biol 26(11):4240-56. [PubMed: 16705174]  [MGI Ref ID J:109620]

Ling H; Sylvestre JR; Jolicoeur P. 2013. Cyclin D1-dependent induction of luminal inflammatory breast tumors by activated notch3. Cancer Res 73(19):5963-73. [PubMed: 23928992]  [MGI Ref ID J:202617]

Ma C; Papermaster D; Cepko CL. 1998. A unique pattern of photoreceptor degeneration in cyclin D1 mutant mice. Proc Natl Acad Sci U S A 95(17):9938-43. [PubMed: 9707579]  [MGI Ref ID J:49399]

Nakajima K; Inagawa M; Uchida C; Okada K; Tane S; Kojima M; Kubota M; Noda M; Ogawa S; Shirato H; Sato M; Suzuki-Migishima R; Hino T; Satoh Y; Kitagawa M; Takeuchi T. 2011. Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway. Development 138(9):1771-82. [PubMed: 21447557]  [MGI Ref ID J:171273]

Pogoriler J; Millen K; Utset M; Du W. 2006. Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation. Development 133(19):3929-37. [PubMed: 16943274]  [MGI Ref ID J:115956]

Rowlands TM; Pechenkina IV; Hatsell SJ; Pestell RG; Cowin P. 2003. Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia. Proc Natl Acad Sci U S A 100(20):11400-5. [PubMed: 13679587]  [MGI Ref ID J:85819]

Sankaran VG; Ludwig LS; Sicinska E; Xu J; Bauer DE; Eng JC; Patterson HC; Metcalf RA; Natkunam Y; Orkin SH; Sicinski P; Lander ES; Lodish HF. 2012. Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. Genes Dev 26(18):2075-87. [PubMed: 22929040]  [MGI Ref ID J:187695]

Sicinska E; Lee YM; Gits J; Shigematsu H; Yu Q; Rebel VI; Geng Y; Marshall CJ; Akashi K; Dorfman DM; Touw IP; Sicinski P. 2006. Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes. Mol Cell Biol 26(21):8052-60. [PubMed: 16954383]  [MGI Ref ID J:114672]

Takahashi M; Kojima M; Nakajima K; Suzuki-Migishima R; Takeuchi T. 2007. Functions of a jumonji-cyclin D1 pathway in the coordination of cell cycle exit and migration during neurogenesis in the mouse hindbrain. Dev Biol 303(2):549-60. [PubMed: 17189626]  [MGI Ref ID J:119194]

Tong W; Pollard JW. 2001. Genetic evidence for the interactions of cyclin D1 and p27(Kip1) in mice. Mol Cell Biol 21(4):1319-28. [PubMed: 11158317]  [MGI Ref ID J:67129]

Tsikitis M; Zhang Z; Edelman W; Zagzag D; Kalpana GV. 2005. Genetic ablation of Cyclin D1 abrogates genesis of rhabdoid tumors resulting from Ini1 loss. Proc Natl Acad Sci U S A 102(34):12129-34. [PubMed: 16099835]  [MGI Ref ID J:101185]

Wang C; Li Z; Lu Y; Du R; Katiyar S; Yang J; Fu M; Leader JE; Quong A; Novikoff PM; Pestell RG. 2006. Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function. Proc Natl Acad Sci U S A 103(31):11567-72. [PubMed: 16864783]  [MGI Ref ID J:111799]

Wang C; Pattabiraman N; Zhou JN; Fu M; Sakamaki T; Albanese C; Li Z; Wu K; Hulit J; Neumeister P; Novikoff PM; Brownlee M; Scherer PE; Jones JG; Whitney KD; Donehower LA; Harris EL; Rohan T; Johns DC; Pestell RG. 2003. Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation. Mol Cell Biol 23(17):6159-73. [PubMed: 12917338]  [MGI Ref ID J:85044]

Yang C; Chen L; Li C; Lynch MC; Brisken C; Schmidt EV. 2010. Cyclin D1 enhances the response to estrogen and progesterone by regulating progesterone receptor expression. Mol Cell Biol 30(12):3111-25. [PubMed: 20404095]  [MGI Ref ID J:162673]

Yang DP; Zhang DP; Mak KS; Bonder DE; Pomeroy SL; Kim HA. 2008. Schwann cell proliferation during Wallerian degeneration is not necessary for regeneration and remyelination of the peripheral nerves: axon-dependent removal of newly generated Schwann cells by apoptosis. Mol Cell Neurosci 38(1):80-8. [PubMed: 18374600]  [MGI Ref ID J:136917]

Yu Q; Geng Y; Sicinski P. 2001. Specific protection against breast cancers by cyclin D1 ablation. Nature 411(6841):1017-21. [PubMed: 11429595]  [MGI Ref ID J:70276]

Zhang M; Xie R; Hou W; Wang B; Shen R; Wang X; Wang Q; Zhu T; Jonason JH; Chen D. 2009. PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation. J Cell Sci 122(Pt 9):1382-9. [PubMed: 19351720]  [MGI Ref ID J:150499]

Zhang Q; Sakamoto K; Liu C; Triplett AA; Lin WC; Rui H; Wagner KU. 2011. Cyclin D3 Compensates for the Loss of Cyclin D1 during ErbB2-Induced Mammary Tumor Initiation and Progression. Cancer Res 71(24):7513-24. [PubMed: 22037875]  [MGI Ref ID J:178842]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Wild-type from the colony
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
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JAX® Services
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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