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Strain Name:

FVB.129P2-Abcb4tm1Bor/J

Stock Number:

002539

Availability:

Repository-Cryopreserved


Link to main datasheet for 002539

Additional References

 

Borst P; Schinkel AH. 1996. What have we learnt thus far from mice with disrupted P-glycoprotein genes? Eur J Cancer 32A(6):985-90. [PubMed: 8763339]  [MGI Ref ID J:33581]

De Vree JM; Ottenhoff R; Bosma PJ; Smith AJ; Aten J; Elferink RP. 2000. Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis Gastroenterology 119(6):1720-30. [PubMed: 11113093]  [MGI Ref ID J:66180]

Dekkers DW; Comfurius P; Schroit AJ; Bevers EM; Zwaal RF. 1998. Transbilayer movement of NBD-labeled phospholipids in red blood cell membranes: outward-directed transport by the multidrug resistance protein 1 (MRP1). Biochemistry 37(42):14833-7. [PubMed: 9778357]  [MGI Ref ID J:51135]

Eisenbraun MD; Miller RA. 1999. mdr1a-encoded P-glycoprotein is not required for peripheral T cell proliferation, cytokine release, or cytotoxic effector function in mice. J Immunol 163(5):2621-7. [PubMed: 10453001]  [MGI Ref ID J:57091]

Fickert P; Fuchsbichler A; Wagner M; Zollner G; Kaser A; Tilg H; Krause R; Lammert F; Langner C; Zatloukal K; Marschall HU; Denk H; Trauner M. 2004. Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology 127(1):261-74. [PubMed: 15236191]  [MGI Ref ID J:93576]

Frijters CM; Tuijn CJ; Ottenhoff R; Zegers BN; Groen AK; Elferink RP. 1999. The role of different P-glycoproteins in hepatobiliary secretion of fluorescently labeled short-chain phospholipids. J Lipid Res 40(11):1950-8. [PubMed: 10552998]  [MGI Ref ID J:119840]

Groen AK; Van Wijland MJ; Frederiks WM; Smit JJ; Schinkel AH; Oude Elferink RP. 1995. Regulation of protein secretion into bile: studies in mice with a disrupted mdr2 p-glycoprotein gene. Gastroenterology 109(6):1997-2006. [PubMed: 7498666]  [MGI Ref ID J:30489]

Hulzebos CV; Voshol PJ; Wolters H; Kruit JK; Ottenhof R; Groen AK; Stellaard F; Verkade HJ; Kuipers F. 2005. Bile duct proliferation associated with bile salt-induced hypercholeresis in Mdr2 P-glycoprotein-deficient mice. Liver Int 25(3):604-12. [PubMed: 15910498]  [MGI Ref ID J:110130]

Katzenellenbogen M; Mizrahi L; Pappo O; Klopstock N; Olam D; Barash H; Domany E; Galun E; Goldenberg D. 2007. Molecular mechanisms of the chemopreventive effect on hepatocellular carcinoma development in Mdr2 knockout mice. Mol Cancer Ther 6(4):1283-91. [PubMed: 17431106]  [MGI Ref ID J:133445]

Katzenellenbogen M; Mizrahi L; Pappo O; Klopstock N; Olam D; Jacob-Hirsch J; Amariglio N; Rechavi G; Domany E; Galun E; Goldenberg D. 2007. Molecular mechanisms of liver carcinogenesis in the mdr2-knockout mice. Mol Cancer Res 5(11):1159-70. [PubMed: 18025261]  [MGI Ref ID J:131750]

Katzenellenbogen M; Pappo O; Barash H; Klopstock N; Mizrahi L; Olam D; Jacob-Hirsch J; Amariglio N; Rechavi G; Mitchell LA; Kohen R; Domany E; Galun E; Goldenberg D. 2006. Multiple adaptive mechanisms to chronic liver disease revealed at early stages of liver carcinogenesis in the Mdr2-knockout mice. Cancer Res 66(8):4001-10. [PubMed: 16618719]  [MGI Ref ID J:108307]

Kok T; Wolters H; Bloks VW; Havinga R; Jansen PL; Staels B; Kuipers F. 2003. Induction of hepatic ABC transporter expression is part of the PPARalpha-mediated fasting response in the mouse. Gastroenterology 124(1):160-71. [PubMed: 12512040]  [MGI Ref ID J:81018]

Kruit JK; Plosch T; Havinga R; Boverhof R; Groot PH; Groen AK; Kuipers F. 2005. Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice. Gastroenterology 128(1):147-56. [PubMed: 15633131]  [MGI Ref ID J:95371]

Lammert F; Wang DQ; Hillebrandt S; Geier A; Fickert P; Trauner M; Matern S; Paigen B; Carey MC. 2004. Spontaneous cholecysto- and hepatolithiasis in Mdr2-/- mice: a model for low phospholipid-associated cholelithiasis. Hepatology 39(1):117-28. [PubMed: 14752830]  [MGI Ref ID J:105357]

Langheim S; Yu L; von Bergmann K; Lutjohann D; Xu F; Hobbs HH; Cohen JC. 2005. ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile. J Lipid Res 46(8):1732-8. [PubMed: 15930516]  [MGI Ref ID J:100491]

Li Z; Agellon LB; Allen TM; Umeda M; Jewell L; Mason A; Vance DE. 2006. The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. Cell Metab 3(5):321-31. [PubMed: 16679290]  [MGI Ref ID J:129649]

Li Z; Agellon LB; Vance DE. 2007. Choline redistribution during adaptation to choline deprivation. J Biol Chem 282(14):10283-9. [PubMed: 17283071]  [MGI Ref ID J:121149]

Li Z; Agellon LB; Vance DE. 2005. Phosphatidylcholine homeostasis and liver failure. J Biol Chem 280(45):37798-802. [PubMed: 16144842]  [MGI Ref ID J:102893]

Mann DA; Oakley F. 2005. NF-kappaB: a signal for cancer. J Hepatol 42(4):610-1. [PubMed: 15763352]  [MGI Ref ID J:97853]

Mauad TH; van Nieuwkerk CM; Dingemans KP; Smit JJ; Schinkel AH; Notenboom RG; van den Bergh Weerman MA; Verkruisen RP; Groen AK; Oude Elferink RP; van der Valk MA; Borst P; Offerhaus GJ. 1994. Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis. Am J Pathol 145(5):1237-45. [PubMed: 7977654]  [MGI Ref ID J:21232]

Minich DM; Voshol PJ; Havinga R; Stellaard F; Kuipers F; Vonk RJ; Verkade HJ. 1999. Biliary phospholipid secretion is not required for intestinal absorption and plasma status of linoleic acid in mice. Biochim Biophys Acta 1441(1):14-22. [PubMed: 10526224]  [MGI Ref ID J:114159]

Mustacich DJ; Shields J; Horton RA; Brown MK; Reed DJ. 1998. Biliary secretion of alpha-tocopherol and the role of the mdr2 P-glycoprotein in rats and mice. Arch Biochem Biophys 350(2):183-92. [PubMed: 9473291]  [MGI Ref ID J:45890]

Oude Elferink RP; Ottenhoff R; van Wijland M; Smit JJ; Schinkel AH; Groen AK. 1995. Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse. J Clin Invest 95(1):31-8. [PubMed: 7814632]  [MGI Ref ID J:22312]

Pikarsky E; Porat RM; Stein I; Abramovitch R; Amit S; Kasem S; Gutkovich-Pyest E; Urieli-Shoval S; Galun E; Ben-Neriah Y. 2004. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 431(7007):461-6. [PubMed: 15329734]  [MGI Ref ID J:92668]

Plosch T; Bloks VW; Baller JF; Havinga R; Verkade HJ; Jansen PL; Kuipers F. 2002. Mdr P-glycoproteins are not essential for biliary excretion of the hydrophobic heme precursor protoporphyrin in a griseofulvin-induced mouse model of erythropoietic protoporphyria. Hepatology 35(2):299-306. [PubMed: 11826402]  [MGI Ref ID J:105815]

Rawles LA; Acuna D; Erickson RP. 2007. The role of multiple drug resistance proteins in fetal and/or placental protection against teratogen-induced orofacial clefting. Mol Reprod Dev 74(11):1483-9. [PubMed: 17440929]  [MGI Ref ID J:128360]

Smith AJ; de Vree JM; Ottenhoff R; Oude Elferink RP; Schinkel AH; Borst P. 1998. Hepatocyte-specific expression of the human MDR3 P-glycoprotein gene restores the biliary phosphatidylcholine excretion absent in Mdr2 (-/-) mice. Hepatology 28(2):530-6. [PubMed: 9696021]  [MGI Ref ID J:50317]

Uhr M; Tontsch A; Namendorf C; Ripke S; Lucae S; Ising M; Dose T; Ebinger M; Rosenhagen M; Kohli M; Kloiber S; Salyakina D; Bettecken T; Specht M; Putz B; Binder EB; Muller-Myhsok B; Holsboer F. 2008. Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression. Neuron 57(2):203-9. [PubMed: 18215618]  [MGI Ref ID J:135234]

Van Nieuwkerk CM; Elferink RP; Groen AK; Ottenhoff R; Tytgat GN; Dingemans KP; Van Den Bergh Weerman MA; Offerhaus GJ. 1996. Effects of Ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene. Gastroenterology 111(1):165-71. [PubMed: 8698195]  [MGI Ref ID J:34646]

Voshol PJ; Havinga R; Wolters H; Ottenhoff R; Princen HM; Oude Elferink RP; Groen AK; Kuipers F. 1998. Reduced plasma cholesterol and increased fecal sterol loss in multidrug resistance gene 2 P-glycoprotein-deficient mice. Gastroenterology 114(5):1024-34. [PubMed: 9558293]  [MGI Ref ID J:47805]

Voshol PJ; Minich DM; Havinga R; Elferink RP; Verkade HJ; Groen AK; Kuipers F. 2000. Postprandial chylomicron formation and fat absorption in multidrug resistance gene 2 P-glycoprotein-deficient mice [see comments] Gastroenterology 118(1):173-82. [PubMed: 10611166]  [MGI Ref ID J:59783]

Voshol PJ; Schwarz M; Rigotti A; Krieger M; Groen AK; Kuipers F. 2001. Down-regulation of intestinal scavenger receptor class B, type I (SR-BI) expression in rodents under conditions of deficient bile delivery to the intestine. Biochem J 356(Pt 2):317-25. [PubMed: 11368757]  [MGI Ref ID J:114411]

Werner A; Havinga R; Perton F; Kuipers F; Verkade HJ. 2006. Lymphatic chylomicron size is inversely related to biliary phospholipid secretion in mice. Am J Physiol Gastrointest Liver Physiol 290(6):G1177-85. [PubMed: 16384875]  [MGI Ref ID J:111087]

Werner A; Minich DM; Havinga R; Bloks V; Van Goor H; Kuipers F; Verkade HJ. 2002. Fat malabsorption in essential fatty acid-deficient mice is not due to impaired bile formation. Am J Physiol Gastrointest Liver Physiol 283(4):G900-8. [PubMed: 12223350]  [MGI Ref ID J:108285]

van der Velde AE; Vrins CL; van den Oever K; Kunne C; Oude Elferink RP; Kuipers F; Groen AK. 2007. Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice. Gastroenterology 133(3):967-75. [PubMed: 17854600]  [MGI Ref ID J:128386]

 

Link to main datasheet for 002539

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