Strain Name:

B6(V)-Cdh23v-2J/J

Stock Number:

002552

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Availability:

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names C57BL/6J-Cdh23v-2J/J    (Changed: 24-FEB-10 )
C57BL/6J-ob-v2J    (Changed: 15-DEC-04 )
Type Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse

Appearance
black, circling
Related Genotype: a/a Cdh23v-2J/Cdh23v-2J

black, unaffected
Related Genotype: a/a Cdh23v-2J/+

Description
Mice homozygous for the waltzer 2J spontaneous mutation (Cdh23v-2J) show the circling, head-tossing, deafness, and hyperactivity typical of the circling mutants. Homozygous mutant mice are very similar to the other waltzer mutants (Cdh23v and Cdh23v-J). Most homozygotes are deaf from birth. Abnormalities of the inner ear include degeneration of the organ of Corti, spiral ganglion, stria vascularis, and saccular macula. Double heterozygotes with shaker-1 (v/+ Myo7ash1/+) are deaf beginning at 3 to 6 months. Double heterozygotes have changes similar to those of the homozygotes in the organ of Corti, stria vascularis, and spiral ganglion, but less severe and with much later onset. Viability and breeding ability are somewhat reduced.

Development
The waltzer 2 Jackson mutation arose spontaneously at The Jackson Laboratory in 1995 in the B6.V-Lepob/J strain (stock #000632) when that congenic was at generation N18. This mutation was bred away from the obese-bearing strain by 2 cycles of backcross-intercross mating of ovarian transplanted hosts bred to C57BL/6J. The colony was then maintained by sibling intercrossing heterozygotes to homozygotes for 17 generations before backcrossing a homozygous male to a C57BL/6J female to genetically refresh to the inbred background. The strain was then maintained by sibling intercross for 3 generations before again backcrossing a homozygous male to C57BL/6J and has been maintained by sibling intercross of heterozygous females with homozygous males since then.

Control Information

  Control
   Heterozygote from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Cdh23
001137   129P1/ReJ
000690   129P3/J
000691   129X1/SvJ
000646   A/J
000647   A/WySnJ
003070   ALR/LtJ
003072   ALS/LtJ
002756   B6.CAST-Cdh23Ahl+/Kjn
010615   B6.CBACa-Cdh23CBA/CaJ/Kjn
004502   B6;AKR-Lxl2/GrsrJ
002432   B6J x B6.C-H2-Kbm1/ByJ-Cdh23v-J/J
001026   BALB/cByJ
000653   BUB/BnJ
005494   C3.129S1(B6)-Grm1rcw/J
000664   C57BL/6J
004764   C57BL/6J-Cdh23v-8J/J
004819   C57BL/6J-Cdh23v-9J/J
003129   C57BL/6J-Epha4rb-2J/GrsrJ
004820   C57BL/6J-Kcne12J/J
004703   C57BL/6J-Kcnq2Nmf134/J
004811   C57BL/6J-nmf110/J
004812   C57BL/6J-nmf111/J
004747   C57BL/6J-nmf118/J
004656   C57BL/6J-nmf88/J
004391   C57BL/6J-Chr 13A/J/NaJ
004385   C57BL/6J-Chr 7A/J/NaJ
000662   C57BLKS/J
000667   C57BR/cdJ
000668   C57L/J
000669   C58/J
010614   CBACa.B6-Cdh23ahl/Kjn
005016   CByJ;B6-Cdh23v-10J/J
000657   CE/J
000670   DBA/1J
001140   DBA/1LacJ
000671   DBA/2J
007048   DBA/2J-Gpnmb+/SjJ
002106   KK/HlJ
000675   LG/J
000676   LP/J
000677   MA/MyJ
001976   NOD/ShiLtJ
002050   NOR/LtJ
000679   P/J
002747   SENCARB/PtJ
002335   SKH2/J
003392   STOCK Crb1rd8/J
000275   V/LeJ
View Strains carrying other alleles of Cdh23     (48 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Usher Syndrome, Type ID; USH1D
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Deafness, Autosomal Recessive 12; DFNB12   (CDH23)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Cdh23v-2J/Cdh23+

        B6(V)-Cdh23v-2J/J
  • hearing/vestibular/ear phenotype
  • increased or absent threshold for auditory brainstem response
    • for some frequencies in mice at 8-10 months of age   (MGI Ref ID J:183898)

Cdh23v-2J/Cdh23v-2J

        B6(V)-Cdh23v-2J/J
  • hearing/vestibular/ear phenotype
  • abnormal ear morphology   (MGI Ref ID J:66698)
    • abnormal cochlear hair cell inter-stereocilial links morphology
      • lateral links that connect stereocilia to each other are sparse and frequently disrupted   (MGI Ref ID J:135991)
      • abnormal cochlear hair bundle tip links morphology
        • apical links are not present in P5 mice   (MGI Ref ID J:135991)
    • abnormal cochlear outer hair cell morphology
      • at E18.5, the outer hair cells (OHCs) appear immature   (MGI Ref ID J:66698)
      • abnormal outer hair cell stereociliary bundle morphology
        • at E18.5, the kinocilium is often misplaced from the lateral pole of each cell and the stereocilia, when present, are positioned correctly   (MGI Ref ID J:66698)
        • at P4, all OHCs project stereocilia, but they are present in random clumps instead of a V-shaped pattern   (MGI Ref ID J:66698)
        • E18.5 embryos have disorganized and fragmented outer hair cell (OHC) stereociliary bundles   (MGI Ref ID J:135991)
        • stereociliary generally assemble into two to three clumps at the cell apical surface instead of forming single V-shaped bundles   (MGI Ref ID J:135991)
        • abnormal outer hair cell kinocilium morphology
          • kinocilia are often dissassocaited from the stereociliary clumps   (MGI Ref ID J:135991)
        • absent outer hair cell stereocilia
          • in some cases at E18.5, outer hair cells (OHCs) projected no recognizable stereocilia   (MGI Ref ID J:66698)
        • decreased outer hair cell stereocilia number
          • in some cases at E18.5, outer hair cells (OHCs) projected fewer stereocilia   (MGI Ref ID J:66698)
    • abnormal inner hair cell stereociliary bundle morphology
      • at E18.5, stereocilia of the inner hair cells (IHCs) are positioned correctly, but are in a disorganized line instead of a crescent shape   (MGI Ref ID J:66698)
      • at P4, IHCs remain disorganized   (MGI Ref ID J:66698)
      • E17.5 embryos have disorganized and fragmented inner hair cell (IHC) stereociliary bundles   (MGI Ref ID J:135991)
      • stereociliary generally assemble into two to three clumps at the cell apical surface instead of forming single V-shaped bundles   (MGI Ref ID J:135991)
      • abnormal inner hair cell kinocilium morphology
        • kinocilia are often dissassociated from the stereociliary clumps   (MGI Ref ID J:135991)
    • abnormal orientation of cochlear hair cell stereociliary bundles
      • kinocillia show large mean deviations from the plane cell polarity axis (PCP) with only 14% of the kinocillia being within 15 degrees of the PCP compared to 84% in wild-type mice   (MGI Ref ID J:135991)
      • the mean absolute kinociliary deviation is 52 degrees compared to 8 degrees in wild-type mice   (MGI Ref ID J:135991)
    • abnormal vestibular hair cell stereociliary bundle morphology
      • at P4, stereocilia appear thick and are often fused and disorganized   (MGI Ref ID J:66698)
  • abnormal ear physiology   (MGI Ref ID J:66698)
    • absent linear vestibular evoked potential
      • VESPs are absent at the maximum stimulus intensity used   (MGI Ref ID J:116914)
    • increased or absent threshold for auditory brainstem response
      • mice at 3-4 weeks of age do not return normal waveforms at a sound pressure level of 100 dB   (MGI Ref ID J:66698)
  • behavior/neurological phenotype
  • abnormal reflex
    • abnormal drop reflex; mice do not demonstrate expected dorsoflexion and spread out the front paws when quickly lowered from ~20 cm above a table surface, while controls do exhibit this behavior   (MGI Ref ID J:116914)
  • circling   (MGI Ref ID J:116914)
  • impaired swimming
    • mice exhibit poor swimming ability; mice can not maneuver in the water and can not remain at the surface   (MGI Ref ID J:116914)
  • vision/eye phenotype
  • *normal* vision/eye phenotype
    • mice do not exhibit signs of retinal degeneration up to 12 months of age and the melanosomes of the retinal pigment epithelium (RPE) are properly localized   (MGI Ref ID J:109546)
    • abnormal eye electrophysiology   (MGI Ref ID J:109546)
    • decreased a wave implicit time
      • electroretinography analysis of mutant retinas show no difference in amplitudes of a- and b-waves, but the implicit times of both waves are significantly faster from the earliest detectable points   (MGI Ref ID J:109546)
    • decreased b wave implicit time
      • electroretinography analysis of mutant retinas show no difference in amplitudes of a- and b-waves, but the implicit times of both waves are significantly faster from the earliest detectable points   (MGI Ref ID J:109546)
  • nervous system phenotype
  • abnormal cochlear hair cell inter-stereocilial links morphology
    • lateral links that connect stereocilia to each other are sparse and frequently disrupted   (MGI Ref ID J:135991)
    • abnormal cochlear hair bundle tip links morphology
      • apical links are not present in P5 mice   (MGI Ref ID J:135991)
  • abnormal cochlear outer hair cell morphology
    • at E18.5, the outer hair cells (OHCs) appear immature   (MGI Ref ID J:66698)
    • abnormal outer hair cell stereociliary bundle morphology
      • at E18.5, the kinocilium is often misplaced from the lateral pole of each cell and the stereocilia, when present, are positioned correctly   (MGI Ref ID J:66698)
      • at P4, all OHCs project stereocilia, but they are present in random clumps instead of a V-shaped pattern   (MGI Ref ID J:66698)
      • E18.5 embryos have disorganized and fragmented outer hair cell (OHC) stereociliary bundles   (MGI Ref ID J:135991)
      • stereociliary generally assemble into two to three clumps at the cell apical surface instead of forming single V-shaped bundles   (MGI Ref ID J:135991)
      • abnormal outer hair cell kinocilium morphology
        • kinocilia are often dissassocaited from the stereociliary clumps   (MGI Ref ID J:135991)
      • absent outer hair cell stereocilia
        • in some cases at E18.5, outer hair cells (OHCs) projected no recognizable stereocilia   (MGI Ref ID J:66698)
      • decreased outer hair cell stereocilia number
        • in some cases at E18.5, outer hair cells (OHCs) projected fewer stereocilia   (MGI Ref ID J:66698)
  • abnormal inner hair cell stereociliary bundle morphology
    • at E18.5, stereocilia of the inner hair cells (IHCs) are positioned correctly, but are in a disorganized line instead of a crescent shape   (MGI Ref ID J:66698)
    • at P4, IHCs remain disorganized   (MGI Ref ID J:66698)
    • E17.5 embryos have disorganized and fragmented inner hair cell (IHC) stereociliary bundles   (MGI Ref ID J:135991)
    • stereociliary generally assemble into two to three clumps at the cell apical surface instead of forming single V-shaped bundles   (MGI Ref ID J:135991)
    • abnormal inner hair cell kinocilium morphology
      • kinocilia are often dissassociated from the stereociliary clumps   (MGI Ref ID J:135991)
  • abnormal orientation of cochlear hair cell stereociliary bundles
    • kinocillia show large mean deviations from the plane cell polarity axis (PCP) with only 14% of the kinocillia being within 15 degrees of the PCP compared to 84% in wild-type mice   (MGI Ref ID J:135991)
    • the mean absolute kinociliary deviation is 52 degrees compared to 8 degrees in wild-type mice   (MGI Ref ID J:135991)
  • abnormal vestibular hair cell stereociliary bundle morphology
    • at P4, stereocilia appear thick and are often fused and disorganized   (MGI Ref ID J:66698)
  • cellular phenotype
  • abnormal inner hair cell kinocilium morphology
    • kinocilia are often dissassociated from the stereociliary clumps   (MGI Ref ID J:135991)
  • abnormal outer hair cell kinocilium morphology
    • kinocilia are often dissassocaited from the stereociliary clumps   (MGI Ref ID J:135991)

Cdh23v-2J/Cdh23v-2J

        involves: C57BL/6J
  • hearing/vestibular/ear phenotype
  • abnormal cochlear hair cell physiology
    • no FM1-43 loading   (MGI Ref ID J:186316)
  • nervous system phenotype
  • abnormal cochlear hair cell physiology
    • no FM1-43 loading   (MGI Ref ID J:186316)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Cdh23v-2J/Cdh23+

        mixed
  • hearing/vestibular/ear phenotype
  • increased susceptibility to age-related hearing loss
    • percentage of animal showing no Preyer reflex in response to the sound stimulus increase from 0% at 1 to 3 months to approximately 30% at 3 to 5 month   (MGI Ref ID J:108877)
  • behavior/neurological phenotype
  • absent pinna reflex
    • percentage of animal showing no Preyer reflex in response to the sound stimulus increase from 0% at 1 to 3 months to approximately 30% at 3 to 5 month   (MGI Ref ID J:108877)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cdh23v-2J related

Developmental Biology Research
Defects in Cell Adhesion Molecules

Neurobiology Research
Hearing Defects
      deafness, nonsyndromic autosomal recessive 12 (DFNB12)
Vestibular Defects

Sensorineural Research
Hearing Defects
      deafness, nonsyndromic autosomal recessive 12 (DFNB12)
Vestibular Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Cdh23v-2J
Allele Name waltzer 2 Jackson
Allele Type Spontaneous
Common Name(s) Cdh23v-2J;
Strain of OriginC57BL/6J
Gene Symbol and Name Cdh23, cadherin 23 (otocadherin)
Chromosome 10
Gene Common Name(s) 4930542A03Rik; CDHR23; RIKEN cDNA 4930542A03 gene; USH1D; W; age related hearing loss 1; ahl; bob; bobby; bus; bustling; mdfw; modifier of deaf waddler; neuroscience mutagenesis facility, 112; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; nmf112; nmf181; nmf252; sals; salsa; v; waltzer;
Molecular Note A G-to-A transition at the first nucleotide of intron 32 alters the wild-type donor splice site. RT-PCR analysis demonstrated that aberrant transcripts were produced from this allele, and all of these were predicted to introduce a premature stop codon. [MGI Ref ID J:66698]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Cdh23v-2J related

Alagramam KN; Goodyear RJ; Geng R; Furness DN; van Aken AF; Marcotti W; Kros CJ; Richardson GP. 2011. Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in Mammalian sensory hair cells. PLoS One 6(4):e19183. [PubMed: 21532990]  [MGI Ref ID J:172400]

Calderon A; Derr A; Stagner BB; Johnson KR; Martin G; Noben-Trauth K. 2006. Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse. Hear Res 221(1-2):44-58. [PubMed: 16962269]  [MGI Ref ID J:113021]

Di Palma F; Holme RH; Bryda EC; Belyantseva IA; Pellegrino R; Kachar B; Steel KP; Noben-Trauth K. 2001. Mutations in cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for usher syndrome type 1D Nat Genet 27(1):103-7. [PubMed: 11138008]  [MGI Ref ID J:66698]

Geng R; Melki S; Chen DH; Tian G; Furness DN; Oshima-Takago T; Neef J; Moser T; Askew C; Horwitz G; Holt JR; Imanishi Y; Alagramam KN. 2012. The Mechanosensory Structure of the Hair Cell Requires Clarin-1, a Protein Encoded by Usher Syndrome III Causative Gene. J Neurosci 32(28):9485-9498. [PubMed: 22787034]  [MGI Ref ID J:186316]

Han F; Yu H; Tian C; Chen HE; Benedict-Alderfer C; Zheng Y; Wang Q; Han X; Zheng QY. 2010. A new mouse mutant of the Cdh23 gene with early-onset hearing loss facilitates evaluation of otoprotection drugs. Pharmacogenomics J :. [PubMed: 20644563]  [MGI Ref ID J:174758]

Holme RH; Steel KP. 2002. Stereocilia defects in waltzer (Cdh23), shaker1 (Myo7a) and double waltzer/shaker1 mutant mice. Hear Res 169(1-2):13-23. [PubMed: 12121736]  [MGI Ref ID J:108877]

Jones SM; Johnson KR; Yu H; Erway LC; Alagramam KN; Pollak N; Jones TA. 2005. A quantitative survey of gravity receptor function in mutant mouse strains. J Assoc Res Otolaryngol 6(4):297-310. [PubMed: 16235133]  [MGI Ref ID J:116914]

Kamiya K; Michel V; Giraudet F; Riederer B; Foucher I; Papal S; Perfettini I; Le Gal S; Verpy E; Xia W; Seidler U; Georgescu MM; Avan P; El-Amraoui A; Petit C. 2014. An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells. Proc Natl Acad Sci U S A 111(25):9307-12. [PubMed: 24920589]  [MGI Ref ID J:212101]

Kim HJ; Jackson T; Noben-Trauth K. 2003. Genetic analyses of the mouse deafness mutations varitint-waddler (va) and jerker (espnje). J Assoc Res Otolaryngol 4(1):83-90. [PubMed: 12209292]  [MGI Ref ID J:78812]

Lefevre G; Michel V; Weil D; Lepelletier L; Bizard E; Wolfrum U; Hardelin JP; Petit C. 2008. A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth. Development 135(8):1427-37. [PubMed: 18339676]  [MGI Ref ID J:135991]

Libby RT; Kitamoto J; Holme RH; Williams DS; Steel KP. 2003. Cdh23 mutations in the mouse are associated with retinal dysfunction but not retinal degeneration. Exp Eye Res 77(6):731-9. [PubMed: 14609561]  [MGI Ref ID J:109546]

Liu S; Li S; Zhu H; Cheng S; Zheng QY. 2012. A mutation in the cdh23 gene causes age-related hearing loss in Cdh23(nmf308/nmf308) mice. Gene 499(2):309-17. [PubMed: 22326520]  [MGI Ref ID J:183808]

Phillips KR; Tong S; Goodyear R; Richardson GP; Cyr JL. 2006. Stereociliary myosin-1c receptors are sensitive to calcium chelation and absent from cadherin 23 mutant mice. J Neurosci 26(42):10777-88. [PubMed: 17050716]  [MGI Ref ID J:113401]

Schwander M; Xiong W; Tokita J; Lelli A; Elledge HM; Kazmierczak P; Sczaniecka A; Kolatkar A; Wiltshire T; Kuhn P; Holt JR; Kachar B; Tarantino L; Muller U. 2009. A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells. Proc Natl Acad Sci U S A 106(13):5252-7. [PubMed: 19270079]  [MGI Ref ID J:147149]

Verpy E; Leibovici M; Michalski N; Goodyear RJ; Houdon C; Weil D; Richardson GP; Petit C. 2011. Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane. J Comp Neurol 519(2):194-210. [PubMed: 21165971]  [MGI Ref ID J:186025]

Vu AA; Nadaraja GS; Huth ME; Luk L; Kim J; Chai R; Ricci AJ; Cheng AG. 2013. Integrity and regeneration of mechanotransduction machinery regulate aminoglycoside entry and sensory cell death. PLoS One 8(1):e54794. [PubMed: 23359017]  [MGI Ref ID J:195927]

Xiong W; Grillet N; Elledge HM; Wagner TF; Zhao B; Johnson KR; Kazmierczak P; Muller U. 2012. TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells. Cell 151(6):1283-95. [PubMed: 23217710]  [MGI Ref ID J:193334]

Zheng QY; Scarborough JD; Zheng Y; Yu H; Choi D; Gillespie PG. 2012. Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genes. Hum Mol Genet 21(11):2588-98. [PubMed: 22381527]  [MGI Ref ID J:183898]

Zheng QY; Yan D; Ouyang XM; Du LL; Yu H; Chang B; Johnson KR; Liu XZ. 2005. Digenic inheritance of deafness caused by mutations in genes encoding cadherin 23 and protocadherin 15 in mice and humans. Hum Mol Genet 14(1):103-11. [PubMed: 15537665]  [MGI Ref ID J:95655]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery of Strains Needing Progeny Testing
    At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 10 and 14 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is no guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation.
    Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation.

    Please contact Customer Service for more information on the cost of progeny testing for a strain, tel: 1-800-422-6423 or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery of Strains Needing Progeny Testing
    At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 10 and 14 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is no guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation.
    Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation.

    Please contact Customer Service for more information on the cost of progeny testing for a strain, tel: 1-800-422-6423 or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.

Control Information

  Control
   Heterozygote from the colony
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Terms of Use


General Terms and Conditions


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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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