Strain Name: |
NOD.129P2(B6)-Il2tm1Hor/DvsJ |
|---|---|
Stock Number: |
002573 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
NOD.129P2(B6)-Il2tm1Hor/Dvs (Changed: 18-MAR-08
) |
| Genes & Alleles | Il2; Il2tm1Hor; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Targeted Mutation Species laboratory mouse H2 Haplotype g7 Appearance
albino, pink eyed
Related Genotype: A/A Tyrc/Tyrc
Gene & Allele Details
| Allele Symbol | Il2tm1Hor | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Ivan Horak | ||
| Common Name(s) | IL-2 KO; IL-2-; IL-2null; Il2-; | ||
| Mutation Made By | Ivan Horak, Forschungs institut fur Molekulare | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Name | E14 | ||
| ES Cell Line Strain | 129P2/OlaHsd | ||
| Gene Symbol and Name | Il2, interleukin 2 | ||
| Chromosome | 3 | ||
| Gene Common Name(s) | IL-2; Il-2; TCGF; lymphokine; | ||
| Molecular Note | Insertion of a neomycin-resistance gene into the third exon introduced several stop codons in all reading frames. [MGI Ref ID J:39989] | ||
Genotyping Protocols
Il2tm1Hor
Related Strains
Strains carrying Il2tm1Hor allele
002252 B6.129P2-Il2tm1Hor/J 002229 C.129P2(B6)-Il2tm1Hor/J 002228 C3.129P2(B6)-Il2tm1Hor/J View Strains carrying Il2tm1Hor (3 strains)
006102 B10.Cg-H2k Tg(Il2/NFAT-luc)83Rinc/J 006098 B6.Cg-Tg(Il2/NFAT-luc)83Rinc/J
Additional Web Information
Congenic Nomenclature
Research Applications
This mouse can be used to support research in many areas including:Il2tm1Hor related
Cancer Research
Growth Factors/Receptors/Cytokines
Hematological Research
Anemia, Iron Deficiency and Transport Defects (hemolytic)
Immunological Defects
Immunology and Inflammation Research
Autoimmunity (hemolytic anemia)
Growth Factors/Receptors/Cytokines
References
Selected Reference(s)
Additional ReferencesSchorle H; Holtschke T; Hunig T; Schimpl A; Horak I. 1991. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352(6336):621-4. [PubMed: 1830926] [MGI Ref ID J:39989]
Price and Supply Information
| Strain Name: | NOD.129P2(B6)-Il2tm1Hor/DvsJ |
| Stock Number: | 002573 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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