Strain Name:

NOD.129S7(B6)-Ifngtm1Ts/DvsJ

Stock Number:

002575

Availability:

Repository-Cryopreserved

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered Mutant Mice.
Specieslaboratory mouse
Background Strain NOD/ShiLt
Donor Strain 129S7 derived AB1 ES cell line
H2 Haplotypeg7
GenerationN7F14p
 
Donating Investigator David Serreze,   The Jackson Laboratory

Appearance
albino
Related Genotype: Tyrc/Tyrc

Description
Mice homozygous for the Ifngtm1Ts targeted mutation are viable and fertile. This Ifng -deficient mutant develops type 1 diabetes at the same rate as the NOD/ShiLt parental strain.

Control Information

  Control
   001976 NOD/ShiLtJ
   Additional control strains are available depending on the researchers needs. Please refer to JAX Notes No. 477 for a complete list of control strains available for NOD/LtJ mice in diabetes research. JAX Notes .
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Ifngtm1Ts allele
002287   B6.129S7-Ifngtm1Ts/J
002286   C.129S7(B6)-Ifngtm1Ts/J
View Strains carrying   Ifngtm1Ts     (2 strains)

Additional Web Information

Congenic Nomenclature
JAX® NOTES, Spring 1999; 477. Control Strains for NOD/LtJ Mice in Diabetes Research.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms
Diabetes Mellitus, Insulin-Dependent; IDDM - Models with phenotypic similarity to human disease where etiologies are distinct.2
2 Human genes are associated with this disease. Orthologs of those genes do not appear in the mouse genotype(s).
View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Ifngtm1Ts/Ifngtm1Ts

        NOD-Ifngtm1Ts
  • immune system phenotype
  • decreased susceptibility to autoimmune diabetes (MGI Ref ID J:95105)
    • null animals challenged with CVB4 at 8 weeks of age show a retarded rate of diabetes (2 consecutive blood glucose measures >240 mg/dl) development compared to saline-treated controls; over the 25-week follow up period, about 30% of CVB4-exposed nulls develop disease versus around 90% of aline-treated controls

Ifngtm1Ts/Ifngtm1Ts

        NOD.129S7(B6)-Ifngtm1Ts/DvsJ
  • immune system phenotype
  • abnormal cytotoxic T cell physiology (MGI Ref ID J:72818)
    • CD8+ T cells injected into Ifng-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis
  • decreased susceptibility to autoimmune diabetes (MGI Ref ID J:72818)
    • when diabetic NOD splenocytes are transferred into mutant NOD mice, only 33% develop diabetes over the course of the observation period
  • digestive/alimentary phenotype
  • abnormal pancreatic beta cell physiology (MGI Ref ID J:72818)
    • islet cells from Ifng-deficient NOD mice are less susceptible to insulin-specific CD8+ cell-induced toxicity
  • endocrine/exocrine gland phenotype
  • abnormal pancreatic beta cell physiology (MGI Ref ID J:72818)
    • islet cells from Ifng-deficient NOD mice are less susceptible to insulin-specific CD8+ cell-induced toxicity
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains (NOD Congenics with Mutations Affecting Cytokine Production by Autoreactive T Cells)

Ifngtm1Ts related

Cancer Research
Growth Factors/Receptors/Cytokines

Hematological Research
Immunological Defects

Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines
Immunodeficiency (multiple immune defects)
Inflammation

Genes & Alleles

Gene & Allele Information

Allele Symbol Ifngtm1Ts
Allele Name targeted mutation 1, Timothy Stewart
Allele Type Targeted (knock-out)
Common Name(s) IFN-g KO; IFN-gamma KO; IFN-gamma-; IFN-gammatm1Ts; IFN-gammaKO; IFNgamma KO; IFNgamma-; Ifn-gtm1Ts; Ifngtm1Ts; Ifngtm1Ts; gko; ifgtm1; ifntm1Ts; ifng-;
Mutation Made By Timothy Stewart,   no forwarding info
Strain of Origin129S7/SvEvBrd-Hprt1<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt1<+>
Gene Symbol and Name Ifng, interferon gamma
Chromosome 10
Gene Common Name(s) IFG; IFI; IFN-gamma; Ifg;
Molecular Note Insertion of a neomycin gene into exon 2, which introduced a termination codon after the first 30 amino acids of the mature protein. [MGI Ref ID J:66802]

Genotyping

Genotyping Information

Genotyping Protocols

Ifngtm1Ts, STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Serreze DV; Chapman HD; Post CM; Johnson EA; Suarez-Pinzon WL; Rabinovitch A. 2001. Th1 to Th2 cytokine shifts in nonobese diabetic mice: sometimes an outcome, rather than the cause, of diabetes resistance elicited by immunostimulation. J Immunol 166(2):1352-9. [PubMed: 11145720]  [MGI Ref ID J:109883]

Additional References

Amiri P; Haak-Frendscho M; Robbins K; McKerrow JH; Stewart T; Jardieu P. 1994. Anti-immunoglobulin E treatment decreases worm burden and egg production in Schistosoma mansoni-infected normal and interferon gamma knockout mice. J Exp Med 180(1):43-51. [PubMed: 8006599]  [MGI Ref ID J:18740]

Cooper AM; Dalton DK; Stewart TA; Griffin JP; Russell DG; Orme IM. 1993. Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med 178(6):2243-7. [PubMed: 8245795]  [MGI Ref ID J:15723]

Savinov AY; Wong FS; Chervonsky AV. 2001. IFN-gamma Affects Homing of Diabetogenic T Cells. J Immunol 167(11):6637-43. [PubMed: 11714835]  [MGI Ref ID J:72818]

Ifngtm1Ts related

Abromson-Leeman S; Bronson R; Luo Y; Berman M; Leeman R; Leeman J; Dorf M. 2004. T-cell properties determine disease site, clinical presentation, and cellular pathology of experimental autoimmune encephalomyelitis. Am J Pathol 165(5):1519-33. [PubMed: 15509523]  [MGI Ref ID J:109724]

Abromson-Leeman S; Ladell DS; Bronson RT; Dorf ME. 2007. Heterogeneity of EAE mediated by multiple distinct T-effector subsets. J Neuroimmunol 192(1-2):3-12. [PubMed: 17976744]  [MGI Ref ID J:128953]

Adams B; Nagy N; Paulart F; Vanderhaeghen ML; Goldman M; Flamand V. 2003. CD8+ T lymphocytes regulating Th2 pathology escape neonatal tolerization. J Immunol 171(10):5071-6. [PubMed: 14607904]  [MGI Ref ID J:117990]

Afanasyeva M; Georgakopoulos D; Belardi DF; Bedja D; Fairweather D; Wang Y; Kaya Z; Gabrielson KL; Rodriguez ER; Caturegli P; Kass DA; Rose NR. 2005. Impaired up-regulation of CD25 on CD4+ T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart failure. Proc Natl Acad Sci U S A 102(1):180-5. [PubMed: 15611472]  [MGI Ref ID J:95757]

Aguilar PV; Paessler S; Carrara AS; Baron S; Poast J; Wang E; Moncayo AC; Anishchenko M; Watts D; Tesh RB; Weaver SC. 2005. Variation in interferon sensitivity and induction among strains of eastern equine encephalitis virus. J Virol 79(17):11300-10. [PubMed: 16103182]  [MGI Ref ID J:101624]

Akhiani AA; Pappo J; Kabok Z; Schon K; Gao W; Franzen LE; Lycke N. 2002. Protection against Helicobacter pylori infection following immunization is IL-12-dependent and mediated by Th1 cells. J Immunol 169(12):6977-84. [PubMed: 12471132]  [MGI Ref ID J:118009]

Alexander WS; Starr R; Fenner JE; Scott CL; Handman E; Sprigg NS; Corbin JE; Cornish AL; Darwiche R; Owczarek CM; Kay TW; Nicola NA; Hertzog PJ; Metcalf D; Hilton DJ. 1999. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98(5):597-608. [PubMed: 10490099]  [MGI Ref ID J:57474]

Aliberti JC; Souto JT; Marino AP; Lannes-Vieira J; Teixeira MM; Farber J; Gazzinelli RT; Silva JS. 2001. Modulation of chemokine production and inflammatory responses in interferon-gamma- and tumor necrosis factor-R1-deficient mice during Trypanosoma cruzi infection. Am J Pathol 158(4):1433-40. [PubMed: 11290561]  [MGI Ref ID J:68668]

Aly S; Laskay T; Mages J; Malzan A; Lang R; Ehlers S. 2007. Interferon-gamma-dependent mechanisms of mycobacteria-induced pulmonary immunopathology: the role of angiostasis and CXCR3-targeted chemokines for granuloma necrosis. J Pathol 212(3):295-305. [PubMed: 17534845]  [MGI Ref ID J:122272]

Ambati BK; Nozaki M; Singh N; Takeda A; Jani PD; Suthar T; Albuquerque RJ; Richter E; Sakurai E; Newcomb MT; Kleinman ME; Caldwell RB; Lin Q; Ogura Y; Orecchia A; Samuelson DA; Agnew DW; St Leger J; Green WR; Mahasreshti PJ; Curiel DT; Kwan D; Marsh H; Ikeda S; Leiper LJ; Collinson JM; Bogdanovich S; Khurana TS; Shibuya M; Baldwin ME; Ferrara N; Gerber HP; De Falco S; Witta J; Baffi JZ; Raisler BJ; Ambati J. 2006. Corneal avascularity is due to soluble VEGF receptor-1. Nature 443(7114):993-7. [PubMed: 17051153]  [MGI Ref ID J:114973]

Amiri P; Haak-Frendscho M; Robbins K; McKerrow JH; Stewart T; Jardieu P. 1994. Anti-immunoglobulin E treatment decreases worm burden and egg production in Schistosoma mansoni-infected normal and interferon gamma knockout mice. J Exp Med 180(1):43-51. [PubMed: 8006599]  [MGI Ref ID J:18740]

Andersen C; Jensen T; Nansen A; Marker O; Thomsen AR. 1999. CD4(+) T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-gamma or IL-4. Int Immunol 11(12):2035-42. [PubMed: 10590269]  [MGI Ref ID J:110491]

Andoh A; Masuda A; Kumazawa Y; Kasajima T. 2002. Serum antibody response and nasal lymphoid tissue (NALT) structure in the absence of IL-4 or IFN-gamma. Cytokine 20(3):107-12. [PubMed: 12453468]  [MGI Ref ID J:102594]

Andoh A; Masuda A; Yamakawa M; Kumazawa Y; Kasajima T. 2000. Absence of interleukin-4 enhances germinal center reaction in secondary immune response. Immunol Lett 73(1):35-41. [PubMed: 10963809]  [MGI Ref ID J:110473]

Andoh M; Zhang G; Russell-Lodrigue KE; Shive HR; Weeks BR; Samuel JE. 2007. T Cells Are Essential for Bacterial Clearance, and Gamma Interferon, Tumor Necrosis Factor Alpha, and B Cells Are Crucial for Disease Development in Coxiella burnetii Infection in Mice. Infect Immun 75(7):3245-55. [PubMed: 17438029]  [MGI Ref ID J:122426]

Andrade RM; Portillo JA; Wessendarp M; Subauste CS. 2005. CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates. Infect Immun 73(5):3115-23. [PubMed: 15845519]  [MGI Ref ID J:97614]

Andreasen SO; Christensen JE; Marker O; Thomsen AR. 2000. Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8+ effector T cell responses. J Immunol 164(7):3689-97. [PubMed: 10725727]  [MGI Ref ID J:123023]

Arantes RM; Marche HH; Bahia MT; Cunha FQ; Rossi MA; Silva JS. 2004. Interferon-gamma-induced nitric oxide causes intrinsic intestinal denervation in Trypanosoma cruzi-infected mice. Am J Pathol 164(4):1361-8. [PubMed: 15039223]  [MGI Ref ID J:89108]

Arens R; Baars PA; Jak M; Tesselaar K; van der Valk M; van Oers MH; van Lier RA. 2005. Cutting edge: CD95 maintains effector T cell homeostasis in chronic immune activation. J Immunol 174(10):5915-20. [PubMed: 15879081]  [MGI Ref ID J:98994]

Arens R; Nolte MA; Tesselaar K; Heemskerk B; Reedquist KA; van Lier RA; van Oers MH. 2004. Signaling through CD70 regulates B cell activation and IgG production. J Immunol 173(6):3901-8. [PubMed: 15356138]  [MGI Ref ID J:92744]

Arora S; Hernandez Y; Erb-Downward JR; McDonald RA; Toews GB; Huffnagle GB. 2005. Role of IFN-gamma in regulating T2 immunity and the development of alternatively activated macrophages during allergic bronchopulmonary mycosis. J Immunol 174(10):6346-56. [PubMed: 15879135]  [MGI Ref ID J:99045]

Arsenijevic D; Clavel S; Sanchis D; Plamondon J; Huang Q; Ricquier D; Rouger L; Richard D. 2007. Induction of Ucp2 expression in brain phagocytes and neurons following murine toxoplasmosis: an essential role of IFN-gamma and an association with negative energy balance. J Neuroimmunol 186(1-2):121-32. [PubMed: 17467814]  [MGI Ref ID J:124552]

Artis D; Villarino A; Silverman M; He W; Thornton EM; Mu S; Summer S; Covey TM; Huang E; Yoshida H; Koretzky G; Goldschmidt M; Wu GD; de Sauvage F; Miller HR; Saris CJ; Scott P; Hunter CA. 2004. The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. J Immunol 173(9):5626-34. [PubMed: 15494513]  [MGI Ref ID J:93739]

Ashkar AA; Croy BA. 1999. Interferon-gamma contributes to the normalcy of murine pregnancy. Biol Reprod 61(2):493-502. [PubMed: 10411532]  [MGI Ref ID J:56503]

Ashkar AA; Di Santo JP; Croy BA. 2000. Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy [see comments] J Exp Med 192(2):259-70. [PubMed: 10899912]  [MGI Ref ID J:63645]

Badovinac VP; Harty JT. 2000. Adaptive immunity and enhanced CD8+ T cell response to Listeria monocytogenes in the absence of perforin and IFN-gamma. J Immunol 164(12):6444-52. [PubMed: 10843700]  [MGI Ref ID J:83175]

Badovinac VP; Tvinnereim AR; Harty JT. 2000. Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma. Science 290(5495):1354-8. [PubMed: 11082062]  [MGI Ref ID J:83176]

Bai Y; Liu R; Huang D; La Cava A; Tang YY; Iwakura Y; Campagnolo DI; Vollmer TL; Ransohoff RM; Shi FD. 2008. CCL2 recruitment of IL-6-producing CD11b(+) monocytes to the draining lymph nodes during the initiation of Th17-dependent B cell-mediated autoimmunity. Eur J Immunol 38(7):1877-88. [PubMed: 18581322]  [MGI Ref ID J:137386]

Balish E; Wagner RD; Vazquez-Torres A; Pierson C; Warner T. 1998. Candidiasis in interferon-gamma knockout (IFN-gamma-/-) mice. J Infect Dis 178(2):478-87. [PubMed: 9697730]  [MGI Ref ID J:120514]

Balomenos D; Rumold R; Theofilopoulos AN. 1998. Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J Clin Invest 101(2):364-71. [PubMed: 9435308]  [MGI Ref ID J:45391]

Bao S; Beagley KW; France MP; Shen J; Husband AJ. 2000. Interferon-gamma plays a critical role in intestinal immunity against Salmonella typhimurium infection. Immunology 99(3):464-72. [PubMed: 10712678]  [MGI Ref ID J:61050]

Barber EM; Fazzari M; Pollard JW. 2005. Th1 cytokines are essential for placental immunity to Listeria monocytogenes. Infect Immun 73(10):6322-31. [PubMed: 16177303]  [MGI Ref ID J:104232]

Bartholdy C; Nansen A; Christensen JE; Marker O; Thomsen AR. 1999. Inducible nitric-oxide synthase plays a minimal role in lymphocytic choriomeningitis virus-induced, T cell-mediated protective immunity and immunopathology. J Gen Virol 80(Pt 11):2997-3005. [PubMed: 10580062]  [MGI Ref ID J:103345]

Bastos KR; de Deus Vieira de Moraes L; Zago CA; Marinho CR; Russo M; Alvarez JM; D'Imperio Lima MR. 2005. Analysis of the activation profile of dendritic cells derived from the bone marrow of interleukin-12/interleukin-23-deficient mice. Immunology 114(4):499-506. [PubMed: 15804287]  [MGI Ref ID J:97435]

Batchelder JM; Burns JM Jr; Cigel FK; Lieberg H; Manning DD; Pepper BJ; Yanez DM; van der Heyde H; Weidanz WP. 2003. Plasmodium chabaudi adami: interferon-gamma but not IL-2 is essential for the expression of cell-mediated immunity against blood-stage parasites in mice. Exp Parasitol 105(2):159-66. [PubMed: 14969693]  [MGI Ref ID J:102606]

Bergmann CC; Parra B; Hinton DR; Chandran R; Morrison M; Stohlman SA. 2003. Perforin-mediated effector function within the central nervous system requires IFN-gamma-mediated MHC up-regulation. J Immunol 170(6):3204-13. [PubMed: 12626579]  [MGI Ref ID J:126219]

Berner V; Liu H; Zhou Q; Alderson KL; Sun K; Weiss JM; Back TC; Longo DL; Blazar BR; Wiltrout RH; Welniak LA; Redelman D; Murphy WJ. 2007. IFN-gamma mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy. Nat Med 13(3):354-60. [PubMed: 17334371]  [MGI Ref ID J:121706]

Betts G; Twohig J; Van den Broek M; Sierro S; Godkin A; Gallimore A. 2007. The impact of regulatory T cells on carcinogen-induced sarcogenesis. Br J Cancer 96(12):1849-54. [PubMed: 17565340]  [MGI Ref ID J:122744]

Bishop DK; Chan Wood S; Eichwald EJ; Orosz CG. 2001. Immunobiology of allograft rejection in the absence of IFN-gamma: CD8+ effector cells develop independently of CD4+ cells and CD40-CD40 ligand interactions. J Immunol 166(5):3248-55. [PubMed: 11207279]  [MGI Ref ID J:126479]

Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. [PubMed: 15153508]  [MGI Ref ID J:90518]

Bitsaktsis C; Nandi B; Racine R; MacNamara KC; Winslow G. 2007. T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection. Infect Immun 75(10):4933-41. [PubMed: 17664264]  [MGI Ref ID J:125283]

Blais ME; Brochu S; Giroux M; Belanger MP; Dulude G; Sekaly RP; Perreault C. 2008. Why T cells of thymic versus extrathymic origin are functionally different. J Immunol 180(4):2299-312. [PubMed: 18250439]  [MGI Ref ID J:131997]

Blazar BR; Carreno BM; Panoskaltsis-Mortari A; Carter L; Iwai Y; Yagita H; Nishimura H; Taylor PA. 2003. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J Immunol 171(3):1272-7. [PubMed: 12874215]  [MGI Ref ID J:120213]

Blazar BR; Lees CJ; Martin PJ; Noelle RJ; Kwon B; Murphy W; Taylor PA. 2000. Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions. J Immunol 165(9):4901-9. [PubMed: 11046015]  [MGI Ref ID J:118027]

Blohm U; Potthoff D; van der Kogel AJ; Pircher H. 2006. Solid tumors 'melt' from the inside after successful CD8 T cell attack. Eur J Immunol 36(2):468-77. [PubMed: 16385625]  [MGI Ref ID J:113858]

Bokhari SM; Kim KJ; Pinson DM; Slusser J; Yeh HW; Parmely MJ. 2008. NK cells and gamma interferon coordinate the formation and function of hepatic granulomas in mice infected with the Francisella tularensis live vaccine strain. Infect Immun 76(4):1379-89. [PubMed: 18227174]  [MGI Ref ID J:133531]

Borjesson DL; Simon SI; Hodzic E; Ballantyne CM; Barthold SW. 2002. Kinetics of CD11b/CD18 up-regulation during infection with the agent of human granulocytic ehrlichiosis in mice. Lab Invest 82(3):303-11. [PubMed: 11896209]  [MGI Ref ID J:75433]

Bouley DM; Kanangat S; Wire W; Rouse BT. 1995. Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-gamma knockout mice. J Immunol 155(8):3964-71. [PubMed: 7561104]  [MGI Ref ID J:29170]

Bour-Jordan H; Thompson HL; Bluestone JA. 2005. Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice. J Immunol 175(9):5649-55. [PubMed: 16237054]  [MGI Ref ID J:119359]

Brandl K; Plitas G; Schnabl B; DeMatteo RP; Pamer EG. 2007. MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. J Exp Med 204(8):1891-900. [PubMed: 17635956]  [MGI Ref ID J:125955]

Bregenholt S; Berche P; Brombacher F; Di Santo JP. 2001. Conventional alpha beta T cells are sufficient for innate and adaptive immunity against enteric Listeria monocytogenes. J Immunol 166(3):1871-6. [PubMed: 11160234]  [MGI Ref ID J:127008]

Brown DM; Dilzer AM; Meents DL; Swain SL. 2006. CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch. J Immunol 177(5):2888-98. [PubMed: 16920924]  [MGI Ref ID J:139502]

Bry L; Brigl M; Brenner MB. 2006. CD4+-T-cell effector functions and costimulatory requirements essential for surviving mucosal infection with Citrobacter rodentium. Infect Immun 74(1):673-81. [PubMed: 16369024]  [MGI Ref ID J:104251]

Buchanan RM; Arulanandam BP; Metzger DW. 1998. IL-12 enhances antibody responses to T-independent polysaccharide vaccines in the absence of T and NK cells. J Immunol 161(10):5525-33. [PubMed: 9820529]  [MGI Ref ID J:115023]

Buhtoiarov IN; Lum HD; Berke G; Sondel PM; Rakhmilevich AL. 2006. Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects. J Immunol 176(1):309-18. [PubMed: 16365423]  [MGI Ref ID J:126263]

Buhtoiarov IN; Sondel PM; Eickhoff JC; Rakhmilevich AL. 2007. Macrophages are essential for antitumour effects against weakly immunogenic murine tumours induced by class B CpG-oligodeoxynucleotides. Immunology 120(3):412-23. [PubMed: 17163960]  [MGI Ref ID J:122619]

Bullen DV; Baldwin TM; Curtis JM; Alexander WS; Handman E. 2003. Persistence of lesions in suppressor of cytokine signaling-1-deficient mice infected with Leishmania major. J Immunol 170(8):4267-72. [PubMed: 12682261]  [MGI Ref ID J:125437]

Bullen DV; Darwiche R; Metcalf D; Handman E; Alexander WS. 2001. Neutralization of interferon-gamma in neonatal SOCS1-/- mice prevents fatty degeneration of the liver but not subsequent fatal inflammatory disease. Immunology 104(1):92-8. [PubMed: 11576226]  [MGI Ref ID J:71691]

Buono C; Come CE; Stavrakis G; Maguire GF; Connelly PW; Lichtman AH. 2003. Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouse. Arterioscler Thromb Vasc Biol 23(3):454-60. [PubMed: 12615659]  [MGI Ref ID J:103072]

Burne MJ; Daniels F; El Ghandour A; Mauiyyedi S; Colvin RB; O'Donnell MP; Rabb H. 2001. Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure. J Clin Invest 108(9):1283-90. [PubMed: 11696572]  [MGI Ref ID J:118005]

Burrell BE; Csencsits K; Lu G; Grabauskiene S; Bishop DK. 2008. CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice. J Immunol 181(6):3906-14. [PubMed: 18768845]  [MGI Ref ID J:139106]

Buxbaum LU; Uzonna JE; Goldschmidt MH; Scott P. 2002. Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent. Eur J Immunol 32(11):3206-15. [PubMed: 12555666]  [MGI Ref ID J:115538]

Caccamo N; Sireci G; Meraviglia S; Dieli F; Ivanyi J; Salerno A. 2006. gammadelta T cells condition dendritic cells in vivo for priming pulmonary CD8 T cell responses against Mycobacterium tuberculosis. Eur J Immunol 36(10):2681-90. [PubMed: 16981183]  [MGI Ref ID J:118094]

Cafruny WA; Bradley SE; Rowland RR. 1999. Regulation of immune complexes during infection of mice with lactate dehydrogenase-elevating virus: studies with interferon-gamma gene knockout and tolerant mice. Viral Immunol 12(2):163-73. [PubMed: 10413362]  [MGI Ref ID J:58076]

Cain JA; Smith JA; Ondr JK; Wang B; Katz JD. 2006. NKT cells and IFN-gamma establish the regulatory environment for the control of diabetogenic T cells in the nonobese diabetic mouse. J Immunol 176(3):1645-54. [PubMed: 16424194]  [MGI Ref ID J:126603]

Campos MA; Closel M; Valente EP; Cardoso JE; Akira S; Alvarez-Leite JI; Ropert C; Gazzinelli RT. 2004. Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88. J Immunol 172(3):1711-8. [PubMed: 14734753]  [MGI Ref ID J:87693]

Campos RA; Szczepanik M; Itakura A; Akahira-Azuma M; Sidobre S; Kronenberg M; Askenase PW. 2003. Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity. J Exp Med 198(12):1785-96. [PubMed: 14676294]  [MGI Ref ID J:132827]

Cannons JL; Yu LJ; Hill B; Mijares LA; Dombroski D; Nichols KE; Antonellis A; Koretzky GA; Gardner K; Schwartzberg PL. 2004. SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1. Immunity 21(5):693-706. [PubMed: 15539155]  [MGI Ref ID J:93887]

Carvalho-Pinto CE; Garcia MI; Mellado M; Rodriguez-Frade JM; Martin-Caballero J; Flores J; Martinez-A C; Balomenos D. 2002. Autocrine production of IFN-gamma by macrophages controls their recruitment to kidney and the development of glomerulonephritis in MRL/lpr mice. J Immunol 169(2):1058-67. [PubMed: 12097414]  [MGI Ref ID J:123834]

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