Strain Name:


Stock Number:


Order this mouse


Repository- Live

Common Names: iNOS-;    
Mice homozygous for the Nos2tm1Lau knock-out synthesize Nos2 de novo in response to inflammatory stimuli with production of nitric oxide (NO). This strain may be useful in studies of inflammatory conditions including rheumatoid arthritis, inflammatory bowel disease, cardiac allograft rejection, hepatoxicity, myocardial ischemia-reperfusion and septic shock.


Strain Information

Type Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
GenerationF39 (25-MAY-11)
Generation Definitions
Donating InvestigatorDr. Victor Laubach,   University of Virginia Health Sci. Ctr.

Related Genotype: a/a

Important Note

Of note, colony managers at The Jackson Laboratory report these mice have a tendency to aggressively barber one another (specifically the whiskers). Attempts to breed away from this characteristic have not been successful to date (June 2009).

Mice homozygous for the Nos2tm1Lau targeted mutation resemble wildtype mice in appearance and histology. Homozygotes are viable and fertile. Unlike Nos1 and Nos3, Nos2 is synthesized de novo in response to a variety of inflammatory stimuli. Induction of Nos2 results in the production of large amounts of nitric oxide (NO) over prolonged periods of time. Excessive NO production has been shown to be beneficial through its antitumor and antimicrobial activities. It is also thought to cause tissue damage and contribute to pathology in a variety of inflammatory conditions including rheumatoid arthritis, inflammatory bowel disease, cardiac allograft rejection, hepatoxicity, myocardial ischemia-reperfusion and septic shock. NO has been demonstrated to play a role in the regulation of blood pressure and hemodynamics. In an LPS-induced model of septic shock, Nos2tm1Lau homozygotes had virtually no serum NO response, but were susceptible to LPS-induced death. Nos2tm1Lau homozygotes exhibit altered responses to M. bovis (BCG), systemic E. coli infection, M. tuberculosis and M.pulmonis. In addition, wound healing properties of fibroblasts are impaired in Nos2tm1Lau homozygotes. Also known as iNOS.

Of note, colony managers at The Jackson Laboratory report these mice have a tendency to aggressively barber one another (specifically the whiskers). Attempts to breed away from this characteristic have not been successful to date (June 2009).

This strain was developed in the laboratory of Dr. Victor Laubach at Glaxo Wellcome Inc. The 129-derived E14TG2a ES cell line was used. The targeting construct was designated as pSPKO-NOS. The ApaI-KpnI fragment containing the calmodulin-binding domain of Nos2 was replaced by the neomycin resistance gene.

Control Information

   100903 B6129PF2/J (approximate)
  Considerations for Choosing Controls

Related Strains

Alzheimer's Disease Models
005987   129-Achetm1Loc/J
006409   129S1.129(Cg)-Tg(APPSw)40Btla/Mmjax
008077   129S1/Sv-Bchetm1Loc/J
016198   129S6.Cg-Tg(Camk2a-tTA)1Mmay/JlwsJ
014556   129S6/SvEv-Apoetm4Mae/J
006555   A.129(B6)-Tg(APPSw)40Btla/Mmjax
005708   B6.129-Apbb1tm1Quhu/J
004714   B6.129-Bace1tm1Pcw/J
004098   B6.129-Klc1tm1Gsn/J
004193   B6.129-Psen1tm1Mpm/J
003615   B6.129-Psen1tm1Shn/J
005300   B6.129-Tg(APPSw)40Btla/Mmjax
005617   B6.129P-Psen2tm1Bdes/J
002609   B6.129P2-Nos2tm1Lau/J
007685   B6.129P2-Psen1tm1Vln/J
007999   B6.129P2-Sorl1Gt(Ex255)Byg/J
008087   B6.129S1-Bchetm1Loc/J
002509   B6.129S2-Plautm1Mlg/J
005301   B6.129S2-Tg(APP)8.9Btla/J
004163   B6.129S4-Cdk5r1tm1Lht/J
010959   B6.129S4-Grk5tm1Rjl/J
010960   B6.129S4-Grk5tm2Rjl/J
002213   B6.129S4-Ngfrtm1Jae/J
006406   B6.129S4-Tg(APPSwLon)96Btla/Mmjax
006469   B6.129S4-Tg(PSEN1H163R)G9Btla/J
012564   B6.129S5-Dhcr24tm1Lex/SbpaJ
004142   B6.129S7-Aplp2tm1Dbo/J
004133   B6.129S7-Apptm1Dbo/J
007251   B6.129X1-Mapttm1Hnd/J
013040   B6.Cg-Apoetm1Unc Ins2Akita/J
005642   B6.Cg-Clutm1Jakh/J
005491   B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
009126   B6.Cg-Nos2tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/Mmjax
005866   B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax
008730   B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
005864   B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax
007575   B6.Cg-Tg(CAG-Ngb,-EGFP)1Dgrn/J
016197   B6.Cg-Tg(CAG-OTC/CAT)4033Prab/J
005855   B6.Cg-Tg(Camk2a-Prkaca)426Tabe/J
007004   B6.Cg-Tg(Camk2a-tTA)1Mmay/DboJ
004996   B6.Cg-Tg(DBH-Gal)1923Stei/J
007673   B6.Cg-Tg(Gad1-EGFP)3Gfng/J
004662   B6.Cg-Tg(PDGFB-APP)5Lms/J
006293   B6.Cg-Tg(PDGFB-APPSwInd)20Lms/2Mmjax
006006   B6.Cg-Tg(Prnp-APP)A-2Dbo/J
008596   B6.Cg-Tg(Prnp-Abca1)EHol/J
006005   B6.Cg-Tg(Prnp-App/APPswe)E1-2Dbo/Mmjax
007180   B6.Cg-Tg(Prnp-ITM2B/APP695*40)1Emcg/J
007182   B6.Cg-Tg(Prnp-ITM2B/APP695*42)A12Emcg/J
005999   B6.Cg-Tg(SBE/TK-luc)7Twc/J
012597   B6.Cg-Tg(Thy1-COL25A1)861Yfu/J
007051   B6.Cg-Tg(tetO-APPSwInd)102Dbo/Mmjax
007052   B6.Cg-Tg(tetO-APPSwInd)107Dbo/Mmjax
007049   B6.Cg-Tg(tetO-APPSwInd)885Dbo/Mmjax
009337   B6.FVB-Tg(Prnp-RTN3)2Yanr/J
006394   B6;129-Apba2tm1Sud Apba3tm1Sud Apba1tm1Sud/J
008364   B6;129-Chattm1(cre/ERT)Nat/J
008476   B6;129-Ncstntm1Sud/J
004807   B6;129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/Mmjax
007605   B6;129P-Psen1tm1Vln/J
005618   B6;129P2-Bace2tm1Bdes/J
008333   B6;129P2-Dldtm1Ptl/J
003822   B6;129S-Psen1tm1Shn/J
012639   B6;129S4-Mapttm3(HDAC2)Jae/J
012869   B6;129S6-Apbb2tm1Her/J
006410   B6;129S6-Chattm2(cre)Lowl/J
005993   B6;129S6-Pcsk9tm1Jdh/J
008636   B6;C-Tg(Prnp-APP695*/EYFP)49Gsn/J
007002   B6;C3-Tg(Prnp-ITM2B/APP695*42)A12Emcg/Mmjax
008169   B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J
000231   B6;C3Fe a/a-Csf1op/J
008850   B6;SJL-Tg(Mt1-LDLR)93-4Reh/AgnJ
003378   B6C3-Tg(APP695)3Dbo Tg(PSEN1)5Dbo/J
004462   B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax
003741   B6D2-Tg(Prnp-MAPT)43Vle/J
016556   B6N.129-Ptpn5tm1Pjlo/J
018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
024841   B6N.Cg-Tg(Prnp-MAPT*P301S)PS19Vle/J
006554   B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
012621   C.129S(B6)-Chrna3tm1.1Hwrt/J
002328   C.129S2-Plautm1Mlg/J
003375   C3B6-Tg(APP695)3Dbo/Mmjax
005087   C57BL/6-Tg(Camk2a-IDE)1Selk/J
005086   C57BL/6-Tg(Camk2a-MME)3Selk/J
008833   C57BL/6-Tg(Camk2a-UBB)3413-1Fwvl/J
007027   C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax
010800   C57BL/6-Tg(Thy1-PTGS2)300Kand/J
010703   C57BL/6-Tg(Thy1-PTGS2)303Kand/J
005706   C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J
006618   C57BL/6-Tg(tetO-COX8A/EYFP)1Ksn/J
007677   CB6-Tg(Gad1-EGFP)G42Zjh/J
007072   CByJ.129P2(B6)-Nos2tm1Lau/J
006472   D2.129(B6)-Tg(APPSw)40Btla/Mmjax
007067   D2.129P2(B6)-Apoetm1Unc/J
013719   D2.Cg-Apoetm1Unc Ins2Akita/J
003718   FVB-Tg(GadGFP)45704Swn/J
013732   FVB-Tg(NPEPPS)1Skar/J
013156   FVB-Tg(tetO-CDK5R1*)1Vln/J
015815   FVB-Tg(tetO-MAPT*P301L)#Kha/JlwsJ
002329   FVB.129S2-Plautm1Mlg/J
025105   FVB.Cg-Tg(Camk2a-tTA)1Mmay/DboJ
003753   FVB/N-Tg(Eno2CDK5R1)1Jdm/J
006143   FVB/N-Tg(Thy1-cre)1Vln/J
025104   FVB/N-Tg(tetO/Prnp-MAPT*P301L,-luc)Y74Dbo/J
008051   NOD.129P2(B6)-Ctsbtm1Jde/RclJ
008390   STOCK Apptm1Sud/J
012640   STOCK Hdac2tm1.2Rdp/J
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
004779   STOCK Mapttm1(EGFP)Klt/J
014092   STOCK Tg(ACTB-tTA2,-MAPT/lacZ)1Luo/J
014544   STOCK Tg(tetO-ABL1*P242E*P249E)CPdav/J
View Alzheimer's Disease Models     (111 strains)

Parkinson's Disease Models
005987   129-Achetm1Loc/J
007587   129S-Park2tm1Rpa/J
002779   129S-Parp1tm1Zqw/J
017001   129S.B6N-Plk2tm1Elan/J
016198   129S6.Cg-Tg(Camk2a-tTA)1Mmay/JlwsJ
004608   B6(Cg)-Htra2mnd2/J
021828   B6(SJL)-Lrrk2tm3.1Mjff/J
021830   B6(SJL)-Lrrk2tm4.1Mjff/GrsrJ
008133   B6.129-Sncbtm1Sud/J
008084   B6.129P2-Drd4tm1Dkg/J
004744   B6.129P2-Esr1tm1Ksk/J
013586   B6.129P2-Gt(ROSA)26Sortm1Nik/J
002609   B6.129P2-Nos2tm1Lau/J
008843   B6.129P2-Sncgtm1Vlb/J
016566   B6.129S-Hcn1tm2Kndl/J
003243   B6.129S-Tnfrsf1atm1Imx Tnfrsf1btm1Imx/J
004322   B6.129S1-Mapk10tm1Flv/J
003190   B6.129S2-Drd2tm1Low/J
006582   B6.129S4-Park2tm1Shn/J
017946   B6.129S4-Pink1tm1Shn/J
005934   B6.129S4-Ucp2tm1Lowl/J
004936   B6.129S6(Cg)-Spp1tm1Blh/J
012453   B6.129X1(FVB)-Lrrk2tm1.1Cai/J
017009   B6.129X1-Nfe2l2tm1Ywk/J
009346   B6.Cg-Lrrk2tm1.1Shn/J
005491   B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
006577   B6.Cg-Park7tm1Shn/J
000567   B6.Cg-T2J +/+ Qkqk-v/J
007004   B6.Cg-Tg(Camk2a-tTA)1Mmay/DboJ
003139   B6.Cg-Tg(DBHn-lacZ)8Rpk/J
007673   B6.Cg-Tg(Gad1-EGFP)3Gfng/J
012466   B6.Cg-Tg(Lrrk2)6Yue/J
012467   B6.Cg-Tg(Lrrk2*G2019S)2Yue/J
008323   B6.Cg-Tg(Mc4r-MAPT/Sapphire)21Rck/J
008321   B6.Cg-Tg(Npy-MAPT/Sapphire)1Rck/J
008324   B6.Cg-Tg(Pmch-MAPT/CFP)1Rck/J
008322   B6.Cg-Tg(Pomc-MAPT/Topaz)1Rck/J
007894   B6.Cg-Tg(Rgs4-EGFP)4Lvt/J
012588   B6.Cg-Tg(TH-ALPP)1Erav/J
012265   B6.Cg-Tg(THY1-SNCA*A30P)TS2Sud/J
008859   B6.Cg-Tg(THY1-SNCA*A53T)F53Sud/J
008135   B6.Cg-Tg(THY1-SNCA*A53T)M53Sud/J
008601   B6.Cg-Tg(Th-cre)1Tmd/J
013583   B6.Cg-Tg(tetO-LRRK2)C7874Cai/J
000544   B6.D2-Cacna1atg/J
012445   B6.FVB-Tg(LRRK2)WT1Mjfa/J
012446   B6.FVB-Tg(LRRK2*G2019S)1Mjfa/J
006660   B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
008364   B6;129-Chattm1(cre/ERT)Nat/J
009688   B6;129-Dbhtm2(Th)Rpa Thtm1Rpa/J
008883   B6;129-Gt(ROSA)26Sortm1(SNCA*A53T)Djmo/TmdJ
008889   B6;129-Gt(ROSA)26Sortm2(SNCA*119)Djmo/TmdJ
008886   B6;129-Gt(ROSA)26Sortm3(SNCA*E46K)Djmo/TmdJ
009347   B6;129-Lrrk2tm1.1Shn/J
016209   B6;129-Lrrk2tm2.1Shn/J
016210   B6;129-Lrrk2tm3.1Shn/J
013050   B6;129-Pink1tm1Aub/J
004807   B6;129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/Mmjax
006390   B6;129-Sncatm1Sud Sncbtm1.1Sud/J
008532   B6;129-Thtm1(cre/Esr1)Nat/J
008333   B6;129P2-Dldtm1Ptl/J
008333   B6;129P2-Dldtm1Ptl/J
003692   B6;129X1-Sncatm1Rosl/J
016575   B6;C3-Tg(PDGFB-LRRK2*G2019S)340Djmo/J
016576   B6;C3-Tg(PDGFB-LRRK2*R1441C)574Djmo/J
008169   B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J
004479   B6;C3-Tg(Prnp-SNCA*A53T)83Vle/J
000231   B6;C3Fe a/a-Csf1op/J
012450   B6;D2-Tg(tetO-SNCA)1Cai/J
013725   B6;SJL-Tg(LRRK2)66Mjff/J
008473   B6;SJL-Tg(THY1-SNCA*A30P)M30Sud/J
008134   B6;SJL-Tg(THY1-SNCA*A30P)TS2Sud/J
016976   B6C3-Tg(tetO-SNCA*A53T)33Vle/J
000506   B6C3Fe a/a-Qkqk-v/J
003741   B6D2-Tg(Prnp-MAPT)43Vle/J
024841   B6N.Cg-Tg(Prnp-MAPT*P301S)PS19Vle/J
018768   B6N.Cg-Tg(SNCA*E46K)3Elan/J
012621   C.129S(B6)-Chrna3tm1.1Hwrt/J
016120   C57BL/6-Lrrk1tm1.1Mjff/J
012444   C57BL/6-Lrrk2tm1Mjfa/J
008389   C57BL/6-Tg(THY1-SNCA)1Sud/J
012769   C57BL/6-Tg(Thy1-Sncg)HvP36Putt/J
005706   C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J
006618   C57BL/6-Tg(tetO-COX8A/EYFP)1Ksn/J
018785   C57BL/6J-Tg(LRRK2*G2019S)2AMjff/J
018786   C57BL/6J-Tg(LRRK2*R1441G)3IMjff/J
008245   C57BL/6J-Tg(Th-SNCA)5Eric/J
008239   C57BL/6J-Tg(Th-SNCA*A30P*A53T)39Eric/J
016122   C57BL/6N-Lrrk1tm1.1Mjff Lrrk2tm1.1Mjff/J
016121   C57BL/6N-Lrrk2tm1.1Mjff/J
016123   C57BL/6N-Sncatm1Mjff/J
016936   C57BL/6N-Tg(Thy1-SNCA)12Mjff/J
017682   C57BL/6N-Tg(Thy1-SNCA)15Mjff/J
007677   CB6-Tg(Gad1-EGFP)G42Zjh/J
025105   FVB.Cg-Tg(Camk2a-tTA)1Mmay/DboJ
009610   FVB/N-Tg(LRRK2)1Cjli/J
009609   FVB/N-Tg(LRRK2*G2019S)1Cjli/J
009604   FVB/N-Tg(LRRK2*R1441G)135Cjli/J
009090   FVB/NJ-Tg(Slc6a3-PARK2*Q311X)AXwy/J
017678   FVB;129-Pink1tm1Aub Tg(Prnp-SNCA*A53T)AAub/J
017744   FVB;129-Tg(Prnp-SNCA*A53T)AAub/J
010710   FVB;129S6-Sncatm1Nbm Tg(SNCA)1Nbm/J
010788   FVB;129S6-Sncatm1Nbm Tg(SNCA*A30P)1Nbm Tg(SNCA*A30P)2Nbm/J
010799   FVB;129S6-Sncatm1Nbm Tg(SNCA*A53T)1Nbm Tg(SNCA*A53T)2Nbm/J
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
000942   STOCK Pitx3ak/2J
014092   STOCK Tg(ACTB-tTA2,-MAPT/lacZ)1Luo/J
006340   STOCK Tg(Gad1-EGFP)98Agmo/J
017000   STOCK Tg(SNCA*E46K)3Elan/J
008474   STOCK Tg(THY1-SNCA*A53T)F53Sud/J
008132   STOCK Tg(THY1-Snca)M1mSud/J
012441   STOCK Tg(tetO-LRRK2*G2019S)E3Cai/J
012442   STOCK Tg(tetO-SNCA*A53T)E2Cai/J
012449   STOCK Tg(teto-LRRK2)C7874Cai/J
View Parkinson's Disease Models     (114 strains)

View Strains carrying   Nos2tm1Lau     (5 strains)

Additional Web Information

Visit the Alzheimer's Disease Mouse Model Resource site for helpful information on Alzheimer's Disease and research resources.

Visit the Parkinson's Disease Resource site for helpful information on Parkinson's and research resources.


Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Hypertension, Essential   (NOS2)
Malaria, Susceptibility to   (NOS2)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype


        involves: 129P2/OlaHsd * C57BL/6
  • mortality/aging
  • increased sensitivity to induced morbidity/mortality
    • reduced survival 8 days after 30 minutes of experimentally induced kidney eschemia relative to controls   (MGI Ref ID J:120673)
  • cardiovascular system phenotype
  • *normal* cardiovascular system phenotype
    • blood pressure and heart rate are normal   (MGI Ref ID J:36559)
    • abnormal systemic arterial blood pressure
      • blood pressure drops less in response to LPS injection than it does in controls   (MGI Ref ID J:106197)
  • homeostasis/metabolism phenotype
  • *normal* homeostasis/metabolism phenotype
    • after injection of platelet-activating factor (PAF), >90% mortality occurs within 30 minutes, similar to wild-type controls   (MGI Ref ID J:113106)
    • pretreatment with wortmannin before PAF treatment confers 100% protection to mutants and wild-type   (MGI Ref ID J:113106)
    • abnormal blood homeostasis   (MGI Ref ID J:120673)
      • decreased circulating leptin level
        • plasma leptin concentrations are significantly reduced   (MGI Ref ID J:94571)
      • increased circulating antidiuretic hormone level
        • elevation in plasma AVP due to LPS injection persists longer than controls, still significantly elevated after 6 hours whereas levels more moderately elevated in controls aftr 4 hours.   (MGI Ref ID J:106197)
      • increased circulating creatinine level
        • higher plasma creatinine levels 24 hours after experimentally induced kidney eschemia than in controls   (MGI Ref ID J:120673)
    • abnormal enzyme/coenzyme level
      • elevated tissue myeloperoxidase levels relative to controls 9 days after kidney eschemia   (MGI Ref ID J:120673)
    • improved glucose tolerance
      • hyperglycemic in the first 30 minutes of a glucose tolerance test   (MGI Ref ID J:72215)
      • return to fasting glucose levels by 90 minutes when controls are still hyperglycemic   (MGI Ref ID J:72215)
    • increased insulin sensitivity   (MGI Ref ID J:72215)
  • immune system phenotype
  • *normal* immune system phenotype
    • homozygotes are indistinguishable from wild-type in appearance, histology, growth rate, reproduction, and in mortality in an LPS-induced model of septic shock   (MGI Ref ID J:29677)
    • growth of Mycobacterium leprae unaffected   (MGI Ref ID J:64036)
    • normal development of Peyer's patches normal developmentof Peyer's patches   (MGI Ref ID J:80204)
    • abnormal adaptive immunity
      • primary immune responses are unaffected   (MGI Ref ID J:90903)
      • increased T cell proliferation
        • increased T-cell proliferative response to protein antigens   (MGI Ref ID J:90903)
        • "clonal burst size" is unchanged   (MGI Ref ID J:90903)
    • abnormal immune system morphology   (MGI Ref ID J:90903)
      • enlarged inguinal lymph nodes
        • increased cellularity of inguinal lymph nodes   (MGI Ref ID J:90903)
      • increased single-positive T cell number
        • increased numbers of both CD4+ and CD8+ cells in inguinal lymph nodes   (MGI Ref ID J:90903)
    • increased susceptibility to bacterial infection
      • intracellular growth of Mycobacterium tuberculosis and Francisella tularensis is increased but to highly variable extent   (MGI Ref ID J:100513)
    • skin inflammation
      • greatly increased granulomatous inflammation when infected with Mycobacterium leprae   (MGI Ref ID J:64036)
      • resembles borderline tuberculoid lesions of leprosy   (MGI Ref ID J:64036)
  • tumorigenesis
  • altered tumor susceptibility
    • increased rate of growth of ascites tumor cells   (MGI Ref ID J:93780)
    • no apoptosis in ascites tumor cells 2 weeks after innoculation   (MGI Ref ID J:93780)
    • growth of solid tumors from ascites tumor cells is prevented   (MGI Ref ID J:93780)
  • adipose tissue phenotype
  • decreased white adipose tissue amount
    • reduced amounts of epididymal white adipose tissue   (MGI Ref ID J:94571)
  • reproductive system phenotype
  • abnormal fertilization
    • significantly higher numbers of 2-celled embryos produced when homozygotes are intercrossed   (MGI Ref ID J:112824)
    • blastocyst formation is similar to controls   (MGI Ref ID J:112824)
    • fertilization rate of mutant sperm and normal ova is significantly higher than controls   (MGI Ref ID J:112824)
    • fertilization rate of mutant ova and normal sperm is much higher than controls   (MGI Ref ID J:112824)
  • abnormal reproductive system morphology   (MGI Ref ID J:84347)
    • abnormal gametogenesis   (MGI Ref ID J:84347)
      • abnormal male meiosis
        • numbers of pachytene spermatocytes and round spermatids are increased   (MGI Ref ID J:84347)
        • decreased apoptosis of pachytene, early round spermatids at stages I-IV, and diplotene dividing spermatocytes at stages XI-XII   (MGI Ref ID J:84347)
        • reduced heat induced apoptosis   (MGI Ref ID J:84347)
      • abnormal sperm number
        • 65.5% increase in sperm content   (MGI Ref ID J:84347)
    • abnormal testis morphology   (MGI Ref ID J:84347)
      • enlarged seminiferous tubules
        • significantly increased diameter and volume   (MGI Ref ID J:84347)
      • increased testis weight
        • 31% increase   (MGI Ref ID J:84347)
  • endocrine/exocrine gland phenotype
  • abnormal testis morphology   (MGI Ref ID J:84347)
    • enlarged seminiferous tubules
      • significantly increased diameter and volume   (MGI Ref ID J:84347)
    • increased testis weight
      • 31% increase   (MGI Ref ID J:84347)
  • hematopoietic system phenotype
  • increased T cell proliferation
    • increased T-cell proliferative response to protein antigens   (MGI Ref ID J:90903)
    • "clonal burst size" is unchanged   (MGI Ref ID J:90903)
  • increased single-positive T cell number
    • increased numbers of both CD4+ and CD8+ cells in inguinal lymph nodes   (MGI Ref ID J:90903)
  • growth/size/body region phenotype
  • increased growth rate
    • experience greater weight gain on a high fat diet   (MGI Ref ID J:72215)
  • behavior/neurological phenotype
  • increased food intake
    • consume 1.6 times as much food as controls on a high fat diet   (MGI Ref ID J:72215)
  • integument phenotype
  • skin inflammation
    • greatly increased granulomatous inflammation when infected with Mycobacterium leprae   (MGI Ref ID J:64036)
    • resembles borderline tuberculoid lesions of leprosy   (MGI Ref ID J:64036)


        involves: 129P2/OlaHsd * C57BL/6J
  • renal/urinary system phenotype
  • increased urine pH
    • small but significant increase in urine pH and bicarbonate concentration   (MGI Ref ID J:64896)
  • homeostasis/metabolism phenotype
  • increased urine pH
    • small but significant increase in urine pH and bicarbonate concentration   (MGI Ref ID J:64896)


  • homeostasis/metabolism phenotype
  • decreased circulating alanine transaminase level
    • following hepatic ischemia and reperfusion compared with similarly treated wild-type mice   (MGI Ref ID J:148923)
  • decreased circulating aspartate transaminase level
    • following hepatic ischemia and reperfusion compared with similarly treated wild-type mice   (MGI Ref ID J:148923)
  • decreased susceptibility to injury
    • following hepatic ischemia and reperfusion, mice exhibit reduced liver injury with improved histology due to only mild signs of vascular changes, necrosis, and apoptosis and decreased serum alanine and aspartate transferase levels, and leukocyte (neutrophils, CD3 lymphocytes, CD4 T cells, and granulocytes) recruitment compared with similarly treated wild-type mice   (MGI Ref ID J:148923)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.


  • mortality/aging
  • *normal* mortality/aging
    • better survival after myocardial infarction than for wild-type controls   (MGI Ref ID J:115413)
    • increased mortality induced by ionizing radiation
      • increased sensitivity to ionizing radiation   (MGI Ref ID J:98135)
  • cardiovascular system phenotype
  • *normal* cardiovascular system phenotype
    • unlike mice null for Nos3, ischemia induced retinal neovascularization is not significantly different from controls   (MGI Ref ID J:106207)
    • abnormal heart morphology   (MGI Ref ID J:108269)
      • abnormal heart ventricle morphology
        • hypoxia causes less increase in the RV/LV+Septum ratio than is found in controls   (MGI Ref ID J:108269)
      • abnormal myocardium layer morphology
        • increased hyalination and patchy loss of cross-striations when on 100% oxygen   (MGI Ref ID J:71505)
    • abnormal physiological neovascularization
      • retinal revascularization after ischemia produces small highly branched blood vessels   (MGI Ref ID J:98135)
      • three fold more branching occurs in revascularization than occurs in controls   (MGI Ref ID J:98135)
    • decreased susceptibility to induced choroidal neovascularization
      • choroidal neovascularization following laser-induced rupture of Bruch's membrane is reduced   (MGI Ref ID J:106207)
    • decreased systemic arterial systolic blood pressure
      • more significant drop in systolic blood pressure after myocardial infarction than is seen in controls   (MGI Ref ID J:104749)
    • increased left ventricle developed pressure
      • left ventricular maximum developed pressure was similar to sham operated animals 4 months after myocardial infarction rather than being reduced as in wild-type controls   (MGI Ref ID J:115413)
  • vision/eye phenotype
  • decreased susceptibility to induced choroidal neovascularization
    • choroidal neovascularization following laser-induced rupture of Bruch's membrane is reduced   (MGI Ref ID J:106207)
  • nervous system phenotype
  • abnormal central nervous system regeneration
    • recover better from compression injury to the spinal cord than do controls, severity of behavioral deficit due to injury is somewhat less   (MGI Ref ID J:110081)
  • abnormal corpus callosum morphology
    • increased myelin pathology after treatment with cuprizone   (MGI Ref ID J:125459)
  • decreased oligodendrocyte number
    • decreased numbers of mature oligodendrocytes after cuprizone treatment   (MGI Ref ID J:125459)
    • numbers of oligodendrocytes reduced to 50% of controls after 3.5 weeks   (MGI Ref ID J:125459)
    • undergo increased apoptosis which is not seen for microglia and astrocytes   (MGI Ref ID J:125459)
  • increased susceptibility to pharmacologically induced seizures
    • shortened latency to seizures induced by kainic acid when on a normal diet   (MGI Ref ID J:107300)
    • behavior responses correspond to grade V seizures   (MGI Ref ID J:107300)
    • latency to seizure is prolonged when fed a ketogenic diet   (MGI Ref ID J:107300)
  • digestive/alimentary phenotype
  • decreased susceptibility to induced colitis
    • less susceptibility to dextran sodium sulfate induced colitis   (MGI Ref ID J:87601)
    • less severe weight loss, blood loss and macroscopic damage   (MGI Ref ID J:87601)
    • improved survival   (MGI Ref ID J:87601)
  • homeostasis/metabolism phenotype
  • abnormal blood coagulation
    • shorter time to thrombus formation and vessel occlusion   (MGI Ref ID J:117987)
    • abnormal platelet physiology
      • increased platelet deposition   (MGI Ref ID J:117987)
  • abnormal glucose homeostasis
    • no effect on streptozotocin induced diabetis   (MGI Ref ID J:95957)
  • enhanced wound healing
    • recover better from compression injury to the spinal cord than do controls, severity of behavioral deficit due to injury is somewhat less   (MGI Ref ID J:110081)
  • increased mortality induced by ionizing radiation
    • increased sensitivity to ionizing radiation   (MGI Ref ID J:98135)
  • behavior/neurological phenotype
  • abnormal eating behavior
    • inhibitory effect of insulin on feeding is enhanced by 10 -8M TNF alpha   (MGI Ref ID J:112153)
  • abnormal frequency of paradoxical sleep
    • significantly more time spent in REM sleep during the light period   (MGI Ref ID J:83571)
    • increased REM sleep results from more REM episodes and shortened periods in between   (MGI Ref ID J:83571)
    • more non REM sleep episodes in light period but of shorter duration   (MGI Ref ID J:83571)
    • significantly less non REM sleep during dark periods   (MGI Ref ID J:83571)
  • increased susceptibility to pharmacologically induced seizures
    • shortened latency to seizures induced by kainic acid when on a normal diet   (MGI Ref ID J:107300)
    • behavior responses correspond to grade V seizures   (MGI Ref ID J:107300)
    • latency to seizure is prolonged when fed a ketogenic diet   (MGI Ref ID J:107300)
  • respiratory system phenotype
  • *normal* respiratory system phenotype
    • alveolar fluid clearance unaffected by amilorid and forskolin which both affect clearance in controls   (MGI Ref ID J:71505)
    • abnormal respiratory bronchiole morphology
      • increased ulceration in 100% oxygen than seen with controls   (MGI Ref ID J:71505)
    • abnormal respiratory system physiology
      • reduced lung injury relative to controls after 55 hours at 100% oxygen   (MGI Ref ID J:71505)
  • immune system phenotype
  • abnormal osteoclast morphology
    • elevated osteoclast surface to bone surface in comparison to controls 7 days after bone reloading   (MGI Ref ID J:112399)
  • decreased susceptibility to induced colitis
    • less susceptibility to dextran sodium sulfate induced colitis   (MGI Ref ID J:87601)
    • less severe weight loss, blood loss and macroscopic damage   (MGI Ref ID J:87601)
    • improved survival   (MGI Ref ID J:87601)
  • hematopoietic system phenotype
  • abnormal osteoclast morphology
    • elevated osteoclast surface to bone surface in comparison to controls 7 days after bone reloading   (MGI Ref ID J:112399)
  • abnormal platelet physiology
    • increased platelet deposition   (MGI Ref ID J:117987)
  • skeleton phenotype
  • abnormal bone mineralization
    • lower mineral aposition rate than in controls 7 days after bone reloading   (MGI Ref ID J:112399)
  • abnormal bone structure
    • less recovery of lost bone volume due to bone unloading 7 days after reloading   (MGI Ref ID J:112399)
    • abnormal osteoclast morphology
      • elevated osteoclast surface to bone surface in comparison to controls 7 days after bone reloading   (MGI Ref ID J:112399)


  • respiratory system phenotype
  • abnormal surfactant physiology
    • following infection with mycoplasma, the numbers of large surfactant aggregates is decreased and higher protein to lipid ratios are present in the bronchoalveolare lavage fluid compared to similarly infected wild-type mice   (MGI Ref ID J:130520)
    • following infection with mycoplasma, the minimal surface area on the pulsating bubble is increased and the levels of surfactant protein are decreased compared to similarly infected wild-type mice   (MGI Ref ID J:130520)
  • behavior/neurological phenotype
  • abnormal circadian rhythm
    • mice display a more pronounced diurnal variation of sleep-wake activity   (MGI Ref ID J:83571)
  • abnormal sleep pattern
    • mice spend more time in REM sleep during the light phase as a result of an increased number of REM episodes and shortened duration of the inter REM intervals   (MGI Ref ID J:83571)
    • mice display a more pronounced diurnal variation of sleep-wake activity   (MGI Ref ID J:83571)
    • mice spend less time in non-REM sleep during the dark phase   (MGI Ref ID J:83571)
    • during the light phase mice spend the same amount of time in non-REM sleep but have a higher number of non-REM episodes of shorter average duration   (MGI Ref ID J:83571)
  • nervous system phenotype
  • abnormal brain wave pattern
    • during non-REM sleep the absolute value of slow wave activity is increased   (MGI Ref ID J:83571)
  • immune system phenotype
  • abnormal inflammatory response
    • unlike in wild-type mice, LPS injection fails to reduce nighttime body temperature relative to saline injected controls   (MGI Ref ID J:103018)
    • decreased inflammatory response
      • fever in response to LPS injection is partially reduced compared to wild-type controls   (MGI Ref ID J:103018)
      • the fever response to LPS is initiated but not sustained   (MGI Ref ID J:103018)
      • however, fever in response to turpentine injection is not different from controls   (MGI Ref ID J:103018)


        involves: 129P2/OlaHsd
  • immune system phenotype
  • *normal* immune system phenotype
    • unlike in mice null for Nos1 or Nos3, no abnormalities in leukocyte rolling or adhesion are detected   (MGI Ref ID J:55936)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Parkinson's Disease
      resistance to MPTP

Nos2tm1Lau related

Immunology, Inflammation and Autoimmunity Research
      Inflammatory bowel disease

Neurobiology Research
Alzheimer's Disease

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Nos2tm1Lau
Allele Name targeted mutation 1, Victor E Laubach
Allele Type Targeted (Null/Knockout)
Common Name(s) NOS2-; NOS2tm/Lau; Nos2tm1Lau; iNOS KO; iNOS-;
Mutation Made ByDr. Victor Laubach,   University of Virginia Health Sci. Ctr.
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14TG2a
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Nos2, nitric oxide synthase 2, inducible
Chromosome 11
Gene Common Name(s) HEP-NOS; INOS; NOS; NOS-II; NOS2A; Nos-2; nitric oxide synthase-2 (brain);
Molecular Note A neomycin cassette replaced exons 12 and 13 of the gene, which encode the calmodulin-binding domain. Northern and Western blots of IFNg/LPS-stimulated peritoneal macrophages showed no detectable Nos2 mRNA or protein, respectively. [MGI Ref ID J:183641] [MGI Ref ID J:29677]


Genotyping Information

Genotyping Protocols

Nos2tm1Laualternate4, High Resolution Melting

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Laubach VE; Shesely EG; Smithies O; Sherman PA. 1995. Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc Natl Acad Sci U S A 92(23):10688-92. [PubMed: 7479866]  [MGI Ref ID J:29677]

Additional References

Guo Y; Jones WK; Xuan YT; Tang XL; Bao W; Wu WJ; Han H; Laubach VE; Ping P; Yang Z; Qiu Y; Bolli R. 1999. The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene [see comments] Proc Natl Acad Sci U S A 96(20):11507-12. [PubMed: 10500207]  [MGI Ref ID J:57975]

Kisley LR; Barrett BS; Bauer AK; Dwyer-Nield LD; Barthel B; Meyer AM; Thompson DC; Malkinson AM. 2002. Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis. Cancer Res 62(23):6850-6. [PubMed: 12460898]  [MGI Ref ID J:80325]

Rivera J; Mukherjee J; Weiss LM; Casadevall A. 2002. Antibody Efficacy in Murine Pulmonary Cryptococcus neoformans Infection: A Role for Nitric Oxide. J Immunol 168(7):3419-27. [PubMed: 11907100]  [MGI Ref ID J:75578]

Nos2tm1Lau related

Abu-Ghanem Y; Cohen H; Buskila Y; Grauer E; Amitai Y. 2008. Enhanced stress reactivity in nitric oxide synthase type 2 mutant mice: findings in support of astrocytic nitrosative modulation of behavior. Neuroscience 156(2):257-65. [PubMed: 18723080]  [MGI Ref ID J:141014]

Adams LB; Job CK; Krahenbuhl JL. 2000. Role of inducible nitric oxide synthase in resistance to Mycobacterium leprae in mice. Infect Immun 68(9):5462-5. [PubMed: 10948185]  [MGI Ref ID J:64036]

Aheng C; Ly N; Kelly M; Ibrahim S; Ricquier D; Alves-Guerra MC; Miroux B. 2011. Deletion of UCP2 in iNOS deficient mice reduces the severity of the disease during experimental autoimmune encephalomyelitis. PLoS One 6(8):e22841. [PubMed: 21857957]  [MGI Ref ID J:176503]

Ahn B; Ohshima H. 2001. Suppression of intestinal polyposis in Apc(Min/+) mice by inhibiting nitric oxide production. Cancer Res 61(23):8357-60. [PubMed: 11731407]  [MGI Ref ID J:73152]

Akita Y; Otani H; Matsuhisa S; Kyoi S; Enoki C; Hattori R; Imamura H; Kamihata H; Kimura Y; Iwasaka T. 2007. Exercise-induced activation of cardiac sympathetic nerve triggers cardioprotection via redox-sensitive activation of eNOS and upregulation of iNOS. Am J Physiol Heart Circ Physiol 292(5):H2051-9. [PubMed: 17259438]  [MGI Ref ID J:125942]

Al Gadban MM; German J; Truman JP; Soodavar F; Riemer EC; Twal WO; Smith KJ; Heller D; Hofbauer AF; Oates JC; Hammad SM. 2012. Lack of nitric oxide synthases increases lipoprotein immune complex deposition in the aorta and elevates plasma sphingolipid levels in lupus. Cell Immunol 276(1-2):42-51. [PubMed: 22560558]  [MGI Ref ID J:188295]

Anand RJ; Dai S; Rippel C; Leaphart C; Qureshi F; Gribar SC; Kohler JW; Li J; Stolz DB; Sodhi C; Hackam DJ. 2008. Activated macrophages inhibit enterocyte gap junctions via the release of nitric oxide. Am J Physiol Gastrointest Liver Physiol 294(1):G109-19. [PubMed: 17975131]  [MGI Ref ID J:130509]

Ando A; Yang A; Mori K; Yamada H; Yamada E; Takahashi K; Saikia J; Kim M; Melia M; Fishman M; Huang P; Campochiaro PA. 2002. Nitric oxide is proangiogenic in the retina and choroid. J Cell Physiol 191(1):116-24. [PubMed: 11920687]  [MGI Ref ID J:106207]

Andrade RM; Portillo JA; Wessendarp M; Subauste CS. 2005. CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates. Infect Immun 73(5):3115-23. [PubMed: 15845519]  [MGI Ref ID J:97614]

Arantes RM; Marche HH; Bahia MT; Cunha FQ; Rossi MA; Silva JS. 2004. Interferon-gamma-induced nitric oxide causes intrinsic intestinal denervation in Trypanosoma cruzi-infected mice. Am J Pathol 164(4):1361-8. [PubMed: 15039223]  [MGI Ref ID J:89108]

Arnett HA; Hellendall RP; Matsushima GK; Suzuki K; Laubach VE; Sherman P; Ting JP. 2002. The protective role of nitric oxide in a neurotoxicant-induced demyelinating model. J Immunol 168(1):427-33. [PubMed: 11751989]  [MGI Ref ID J:125459]

Bandeira M; Santos CS; de Azevedo EC; Soares LM; Macedo JO; Marchi S; da Silva CL; Chagas-Junior AD; McBride AJ; McBride FW; Reis MG; Athanazio DA. 2011. Attenuated Nephritis in Inducible Nitric Oxide Synthase Knockout C57BL/6 Mice and Pulmonary Hemorrhage in CB17 SCID and Recombination Activating Gene 1 Knockout C57BL/6 Mice Infected with Leptospira interrogans. Infect Immun 79(7):2936-40. [PubMed: 21576342]  [MGI Ref ID J:173478]

Barrios B; Baez NS; Reynolds D; Iribarren P; Cejas H; Young HA; Rodriguez-Galan MC. 2014. Abrogation of TNFalpha production during cancer immunotherapy is crucial for suppressing side effects due to the systemic expression of IL-12. PLoS One 9(2):e90116. [PubMed: 24587231]  [MGI Ref ID J:214472]

Bartholdy C; Nansen A; Christensen JE; Marker O; Thomsen AR. 1999. Inducible nitric-oxide synthase plays a minimal role in lymphocytic choriomeningitis virus-induced, T cell-mediated protective immunity and immunopathology. J Gen Virol 80(Pt 11):2997-3005. [PubMed: 10580062]  [MGI Ref ID J:103345]

Bast A; Erttmann SF; Walther R; Steinmetz I. 2010. Influence of iNOS and COX on peroxiredoxin gene expression in primary macrophages. Free Radic Biol Med 49(12):1881-91. [PubMed: 20869433]  [MGI Ref ID J:167094]

Becerril S; Rodriguez A; Catalan V; Sainz N; Ramirez B; Collantes M; Penuelas I; Gomez-Ambrosi J; Fruhbeck G. 2010. Deletion of inducible nitric-oxide synthase in leptin-deficient mice improves brown adipose tissue function. PLoS One 5(6):e10962. [PubMed: 20532036]  [MGI Ref ID J:161815]

Beck PL; Li Y; Wong J; Chen CW; Keenan CM; Sharkey KA; McCafferty DM. 2007. Inducible nitric oxide synthase from bone marrow-derived cells plays a critical role in regulating colonic inflammation. Gastroenterology 132(5):1778-90. [PubMed: 17449036]  [MGI Ref ID J:128325]

Beck PL; Xavier R; Wong J; Ezedi I; Mashimo H; Mizoguchi A; Mizoguchi E; Bhan AK; Podolsky DK. 2004. Paradoxical roles of different nitric oxide synthase isoforms in colonic injury. Am J Physiol Gastrointest Liver Physiol 286(1):G137-47. [PubMed: 14665440]  [MGI Ref ID J:87601]

Beisiegel M; Mollenkopf HJ; Hahnke K; Koch M; Dietrich I; Reece ST; Kaufmann SH. 2009. Combination of host susceptibility and Mycobacterium tuberculosis virulence define gene expression profile in the host. Eur J Immunol 39(12):3369-84. [PubMed: 19795415]  [MGI Ref ID J:155483]

Bhandari V; Choo-Wing R; Harijith A; Sun H; Syed MA; Homer RJ; Elias JA. 2012. Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2. Am J Respir Cell Mol Biol 46(5):668-76. [PubMed: 22227562]  [MGI Ref ID J:196034]

Blanchard TG; Yu F; Hsieh CL; Redline RW. 2003. Severe inflammation and reduced bacteria load in murine helicobacter infection caused by lack of phagocyte oxidase activity. J Infect Dis 187(10):1609-15. [PubMed: 12721941]  [MGI Ref ID J:120653]

Blyszczuk P; Berthonneche C; Behnke S; Glonkler M; Moch H; Pedrazzini T; Luscher TF; Eriksson U; Kania G. 2013. Nitric oxide synthase 2 is required for conversion of pro-fibrogenic inflammatory CD133(+) progenitors into F4/80(+) macrophages in experimental autoimmune myocarditis. Cardiovasc Res 97(2):219-29. [PubMed: 23090609]  [MGI Ref ID J:210288]

Bokhari SM; Kim KJ; Pinson DM; Slusser J; Yeh HW; Parmely MJ. 2008. NK cells and gamma interferon coordinate the formation and function of hepatic granulomas in mice infected with the Francisella tularensis live vaccine strain. Infect Immun 76(4):1379-89. [PubMed: 18227174]  [MGI Ref ID J:133531]

Boyer L; Plantier L; Dagouassat M; Lanone S; Goven D; Caramelle P; Berrehar F; Kerbrat S; Dinh-Xuan AT; Crestani B; Le Gouvello S; Boczkowski J. 2011. Role of nitric oxide synthases in elastase-induced emphysema. Lab Invest 91(3):353-62. [PubMed: 20956973]  [MGI Ref ID J:169267]

Brahmachari S; Pahan K. 2010. Myelin basic protein priming reduces the expression of Foxp3 in T cells via nitric oxide. J Immunol 184(4):1799-809. [PubMed: 20083653]  [MGI Ref ID J:159486]

Brahmachari S; Pahan K. 2009. Suppression of regulatory T cells by IL-12p40 homodimer via nitric oxide. J Immunol 183(3):2045-58. [PubMed: 19587012]  [MGI Ref ID J:151706]

Bratt JM; Franzi LM; Linderholm AL; Last MS; Kenyon NJ; Last JA. 2009. Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin. Toxicol Appl Pharmacol 234(3):273-80. [PubMed: 19027033]  [MGI Ref ID J:145875]

Breitbach K; Klocke S; Tschernig T; van Rooijen N; Baumann U; Steinmetz I. 2006. Role of Inducible Nitric Oxide Synthase and NADPH Oxidase in Early Control of Burkholderia pseudomallei Infection in Mice. Infect Immun 74(11):6300-6309. [PubMed: 17000727]  [MGI Ref ID J:113561]

Brumshagen C; Maus R; Bischof A; Ueberberg B; Bohling J; Osterholzer JJ; Ogunniyi AD; Paton JC; Welte T; Maus UA. 2012. FMS-like tyrosine kinase 3 ligand treatment of mice aggravates acute lung injury in response to Streptococcus pneumoniae: role of pneumolysin. Infect Immun 80(12):4281-90. [PubMed: 23006850]  [MGI Ref ID J:190619]

Buhtoiarov IN; Lum HD; Berke G; Sondel PM; Rakhmilevich AL. 2006. Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects. J Immunol 176(1):309-18. [PubMed: 16365423]  [MGI Ref ID J:126263]

Burrer R; Buchmeier MJ; Wolfe T; Ting JP; Feuer R; Iglesias A; von Herrath MG. 2007. Exacerbated pathology of viral encephalitis in mice with central nervous system-specific autoantibodies. Am J Pathol 170(2):557-66. [PubMed: 17255324]  [MGI Ref ID J:117906]

Buskila Y; Abu-Ghanem Y; Levi Y; Moran A; Grauer E; Amitai Y. 2007. Enhanced astrocytic nitric oxide production and neuronal modifications in the neocortex of a NOS2 mutant mouse. PLoS ONE 2(9):e843. [PubMed: 17786214]  [MGI Ref ID J:129384]

Buxbaum LU; Uzonna JE; Goldschmidt MH; Scott P. 2002. Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent. Eur J Immunol 32(11):3206-15. [PubMed: 12555666]  [MGI Ref ID J:115538]

Cambien B; Bergmeier W; Saffaripour S; Mitchell HA; Wagner DD. 2003. Antithrombotic activity of TNF-alpha. J Clin Invest 112(10):1589-96. [PubMed: 14617760]  [MGI Ref ID J:117987]

Carnio EC; Stabile AM; Batalhao ME; Silva JS; Antunes-Rodrigues J; Branco LG; Magder S. 2005. Vasopressin release during endotoxaemic shock in mice lacking inducible nitric oxide synthase. Pflugers Arch 450(6):390-4. [PubMed: 15971084]  [MGI Ref ID J:106197]

Cauwels A; Janssen B; Buys E; Sips P; Brouckaert P. 2006. Anaphylactic shock depends on PI3K and eNOS-derived NO. J Clin Invest 116(8):2244-51. [PubMed: 16886062]  [MGI Ref ID J:113106]

Cauwels A; Van Molle W; Janssen B; Everaerdt B; Huang P; Fiers W; Brouckaert P. 2000. Protection against TNF-induced lethal shock by soluble guanylate cyclase inhibition requires functional inducible nitric oxide synthase. Immunity 13(2):223-31. [PubMed: 10981965]  [MGI Ref ID J:64176]

Cha HN; Kim YW; Kim JY; Kim YD; Song IH; Min KN; Park SY. 2010. Lack of inducible nitric oxide synthase does not prevent aging-associated insulin resistance. Exp Gerontol 45(9):711-8. [PubMed: 20493940]  [MGI Ref ID J:164264]

Chan JY; Cooney GJ; Biden TJ; Laybutt DR. 2011. Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells. Diabetologia 54(7):1766-76. [PubMed: 21472432]  [MGI Ref ID J:172611]

Charbonneau A; Marette A. 2010. Inducible nitric oxide synthase induction underlies lipid-induced hepatic insulin resistance in mice: potential role of tyrosine nitration of insulin signaling proteins. Diabetes 59(4):861-71. [PubMed: 20103705]  [MGI Ref ID J:164330]

Chatterjee S; Lardinois O; Bonini MG; Bhattacharjee S; Stadler K; Corbett J; Deterding LJ; Tomer KB; Kadiiska M; Mason RP. 2009. Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis. J Immunol 183(6):4055-66. [PubMed: 19717511]  [MGI Ref ID J:152293]

Chauhan SD; Seggara G; Vo PA; Macallister RJ; Hobbs AJ; Ahluwalia A. 2003. Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice. FASEB J 17(6):773-5. [PubMed: 12586741]  [MGI Ref ID J:118016]

Chen L; Majde JA; Krueger JM. 2003. Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes. Brain Res 973(2):214-22. [PubMed: 12738065]  [MGI Ref ID J:83571]

Chen L; Taishi P; Duricka D; Krueger JM. 2004. Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity. Brain Res Mol Brain Res 129(1-2):179-84. [PubMed: 15469894]  [MGI Ref ID J:115454]

Chen L; Taishi P; Majde JA; Peterfi Z; Obal F Jr; Krueger JM. 2004. The role of nitric oxide synthases in the sleep responses to tumor necrosis factor-alpha. Brain Behav Immun 18(4):390-8. [PubMed: 15157956]  [MGI Ref ID J:105452]

Chiang E; Dang O; Anderson K; Matsuzawa A; Ichijo H; David M. 2006. Cutting edge: apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide. J Immunol 176(10):5720-4. [PubMed: 16670275]  [MGI Ref ID J:131688]

Choi KS; Song EK; Yim CY. 2008. Cytokines secreted by IL-2-activated lymphocytes induce endogenous nitric oxide synthesis and apoptosis in macrophages. J Leukoc Biol 83(6):1440-50. [PubMed: 18339892]  [MGI Ref ID J:136847]

Chyu KY; Dimayuga P; Zhu J; Nilsson J; Kaul S; Shah PK; Cercek B. 1999. Decreased neointimal thickening after arterial wall injury in inducible nitric oxide synthase knockout mice. Circ Res 85(12):1192-8. [PubMed: 10590247]  [MGI Ref ID J:59834]

Cohen O; Ish-Shalom E; Kfir-Erenfeld S; Herr I; Yefenof E. 2012. Nitric oxide and glucocorticoids synergize in inducing apoptosis of CD4(+)8(+) thymocytes: implications for 'Death by Neglect' and T-cell function. Int Immunol 24(12):783-91. [PubMed: 22949567]  [MGI Ref ID J:190546]

Cole C; Thomas S; Filak H; Henson PM; Lenz LL. 2012. Nitric oxide increases susceptibility of Toll-like receptor-activated macrophages to spreading Listeria monocytogenes. Immunity 36(5):807-20. [PubMed: 22542147]  [MGI Ref ID J:187324]

Cole MP; Chaiswing L; Oberley TD; Edelmann SE; Piascik MT; Lin SM; Kiningham KK; St Clair DK. 2006. The protective roles of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity. Cardiovasc Res 69(1):186-97. [PubMed: 16157314]  [MGI Ref ID J:133742]

Cole MP; Tangpong J; Oberley TD; Chaiswing L; Kiningham KK; St Clair DK. 2014. Nuclear interaction between ADR-induced p65 and p53 mediates cardiac injury in iNOS (-/-) mice. PLoS One 9(2):e89251. [PubMed: 24586632]  [MGI Ref ID J:213759]

Collazo CM; Meierovics AI; De Pascalis R; Wu TH; Lyons CR; Elkins KL. 2009. T cells from lungs and livers of Francisella tularensis-immune mice control the growth of intracellular bacteria. Infect Immun 77(5):2010-21. [PubMed: 19237526]  [MGI Ref ID J:148524]

Colton CA; Vitek MP; Wink DA; Xu Q; Cantillana V; Previti ML; Van Nostrand WE; Weinberg B; Dawson H. 2006. NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 103(34):12867-72. [PubMed: 16908860]  [MGI Ref ID J:112919]

Colton CA; Wilcock DM; Wink DA; Davis J; Van Nostrand WE; Vitek MP. 2008. The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP. J Alzheimers Dis 15(4):571-87. [PubMed: 19096157]  [MGI Ref ID J:143551]

Comtois AS; El-Dwairi Q; Laubach VE; Hussain SN. 1999. Lipopolysaccharide-induced diaphragmatic contractile dysfunction in mice lacking the inducible nitric oxide synthase. Am J Respir Crit Care Med 159(6):1975-80. [PubMed: 10351947]  [MGI Ref ID J:57227]

Cowley SC; Hamilton E; Frelinger JA; Su J; Forman J; Elkins KL. 2005. CD4-CD8- T cells control intracellular bacterial infections both in vitro and in vivo. J Exp Med 202(2):309-19. [PubMed: 16027239]  [MGI Ref ID J:100513]

Cuenca J; Martin-Sanz P; Alvarez-Barrientos AM; Bosca L; Goren N. 2006. Infiltration of Inflammatory Cells Plays an Important Role in Matrix Metalloproteinase Expression and Activation in the Heart during Sepsis. Am J Pathol 169(5):1567-76. [PubMed: 17071581]  [MGI Ref ID J:114564]

Cusumano ZT; Watson ME Jr; Caparon MG. 2014. Streptococcus pyogenes arginine and citrulline catabolism promotes infection and modulates innate immunity. Infect Immun 82(1):233-42. [PubMed: 24144727]  [MGI Ref ID J:206198]

D'Alessio FR; Tsushima K; Aggarwal NR; Mock JR; Eto Y; Garibaldi BT; Files DC; Avalos CR; Rodriguez JV; Waickman AT; Reddy SP; Pearse DB; Sidhaye VK; Hassoun PM; Crow MT; King LS. 2012. Resolution of experimental lung injury by monocyte-derived inducible nitric oxide synthase. J Immunol 189(5):2234-45. [PubMed: 22844117]  [MGI Ref ID J:189863]

Dai M; Yang Y; Omelchenko I; Nuttall AL; Kachelmeier A; Xiu R; Shi X. 2010. Bone marrow cell recruitment mediated by inducible nitric oxide synthase/stromal cell-derived factor-1alpha signaling repairs the acoustically damaged cochlear blood-labyrinth barrier. Am J Pathol 177(6):3089-99. [PubMed: 21057001]  [MGI Ref ID J:167627]

Dal Secco D; Paron JA; de Oliveira SH; Ferreira SH; Silva JS; Cunha Fde Q. 2003. Neutrophil migration in inflammation: nitric oxide inhibits rolling, adhesion and induces apoptosis. Nitric Oxide 9(3):153-64. [PubMed: 14732339]  [MGI Ref ID J:118999]

Dallaire P; Bellmann K; Laplante M; Gelinas S; Centeno-Baez C; Penfornis P; Peyot ML; Latour MG; Lamontagne J; Trujillo ME; Scherer PE; Prentki M; Deshaies Y; Marette A. 2008. Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism. Diabetes 57(8):1999-2011. [PubMed: 18458147]  [MGI Ref ID J:141699]

Davie SA; Maglione JE; Manner CK; Young D; Cardiff RD; MacLeod CL; Ellies LG. 2007. Effects of FVB/NJ and C57Bl/6J strain backgrounds on mammary tumor phenotype in inducible nitric oxide synthase deficient mice. Transgenic Res 16(2):193-201. [PubMed: 17206489]  [MGI Ref ID J:121391]

De Luca G; Di Giorgio RM; Macaione S; Calpona PR; Di Paola ED; Costa N; Cuzzocrea S; Citraro R; Russo E; De Sarro G. 2006. Amino acid levels in some brain areas of inducible nitric oxide synthase knock out mouse (iNOS-/-) before and after pentylenetetrazole kindling. Pharmacol Biochem Behav 85(4):804-12. [PubMed: 17223186]  [MGI Ref ID J:124504]

Demchenko IT; Atochin DN; Gutsaeva DR; Godfrey RR; Huang PL; Piantadosi CA; Allen BW. 2008. Contributions of nitric oxide synthase isoforms to pulmonary oxygen toxicity, local vs. mediated effects. Am J Physiol Lung Cell Mol Physiol 294(5):L984-90. [PubMed: 18326824]  [MGI Ref ID J:136632]

Denda A; Kitayama W; Kishida H; Murata N; Tamura K; Kusuoka O; Tsutsumi M; Nishikawa F; Kita E; Nakae D; Konishi Y; Kuniyasu H. 2007. Expression of inducible nitric oxide (NO) synthase but not prevention by its gene ablation of hepatocarcinogenesis with fibrosis caused by a choline-deficient, L-amino acid-defined diet in rats and mice. Nitric Oxide 16(1):164-76. [PubMed: 16931074]  [MGI Ref ID J:118071]

Deppong CM; Bricker TL; Rannals BD; Van Rooijen N; Hsieh CS; Green JM. 2013. CTLA4Ig inhibits effector T cells through regulatory T cells and TGF-beta. J Immunol 191(6):3082-9. [PubMed: 23956428]  [MGI Ref ID J:205876]

Dhar N; McKinney JD. 2010. Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice. Proc Natl Acad Sci U S A 107(27):12275-80. [PubMed: 20566858]  [MGI Ref ID J:162073]

Di Marco S; Mazroui R; Dallaire P; Chittur S; Tenenbaum SA; Radzioch D; Marette A; Gallouzi IE. 2005. NF-(kappa)B-mediated MyoD decay during muscle wasting requires nitric oxide synthase mRNA stabilization, HuR protein, and nitric oxide release. Mol Cell Biol 25(15):6533-45. [PubMed: 16024790]  [MGI Ref ID J:100108]

DiMagno MJ; Hao Y; Tsunoda Y; Williams JA; Owyang C. 2004. Secretagogue-stimulated pancreatic secretion is differentially regulated by constitutive NOS isoforms in mice. Am J Physiol Gastrointest Liver Physiol 286(3):G428-36. [PubMed: 14551061]  [MGI Ref ID J:95674]

Dias MB; Almeida MC; Carnio EC; Branco LG. 2005. Role of nitric oxide in tolerance to lipopolysaccharide in mice. J Appl Physiol 98(4):1322-7. [PubMed: 15579566]  [MGI Ref ID J:110018]

Diesen DL; Hess DT; Stamler JS. 2008. Hypoxic vasodilation by red blood cells: evidence for an s-nitrosothiol-based signal. Circ Res 103(5):545-53. [PubMed: 18658051]  [MGI Ref ID J:152645]

Duque-Correa MA; Kuhl AA; Rodriguez PC; Zedler U; Schommer-Leitner S; Rao M; Weiner J 3rd; Hurwitz R; Qualls JE; Kosmiadi GA; Murray PJ; Kaufmann SH; Reece ST. 2014. Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas. Proc Natl Acad Sci U S A 111(38):E4024-32. [PubMed: 25201986]  [MGI Ref ID J:216485]

Edelson BT; Unanue ER. 2002. MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity. J Immunol 169(7):3869-75. [PubMed: 12244184]  [MGI Ref ID J:120406]

Eigenbrod T; Bode KA; Dalpke AH. 2013. Early inhibition of IL-1beta expression by IFN-gamma is mediated by impaired binding of NF-kappaB to the IL-1beta promoter but is independent of nitric oxide. J Immunol 190(12):6533-41. [PubMed: 23667107]  [MGI Ref ID J:204860]

Ellies LG. 2003. PyV-mT-induced parotid gland hyperplasia as detected by altered lectin reactivity is not modulated by inducible nitric oxide deficiency. Arch Oral Biol 48(6):415-22. [PubMed: 12749913]  [MGI Ref ID J:84218]

Ellies LG; Fishman M; Hardison J; Kleeman J; Maglione JE; Manner CK; Cardiff RD; MacLeod CL. 2003. Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase. Int J Cancer 106(1):1-7. [PubMed: 12794750]  [MGI Ref ID J:84004]

Everts B; Amiel E; Huang SC; Smith AM; Chang CH; Lam WY; Redmann V; Freitas TC; Blagih J; van der Windt GJ; Artyomov MN; Jones RG; Pearce EL; Pearce EJ. 2014. TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKvarepsilon supports the anabolic demands of dendritic cell activation. Nat Immunol 15(4):323-32. [PubMed: 24562310]  [MGI Ref ID J:209894]

Everts B; Amiel E; van der Windt GJ; Freitas TC; Chott R; Yarasheski KE; Pearce EL; Pearce EJ. 2012. Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. Blood 120(7):1422-31. [PubMed: 22786879]  [MGI Ref ID J:189164]

Fabis MJ; Scott GS; Kean RB; Koprowski H; Hooper DC. 2007. Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models. Proc Natl Acad Sci U S A 104(13):5656-61. [PubMed: 17372191]  [MGI Ref ID J:120115]

Falcone S; Perrotta C; De Palma C; Pisconti A; Sciorati C; Capobianco A; Rovere-Querini P; Manfredi AA; Clementi E. 2004. Activation of acid sphingomyelinase and its inhibition by the nitric oxide/cyclic guanosine 3',5'-monophosphate pathway: key events in Escherichia coli-elicited apoptosis of dendritic cells. J Immunol 173(7):4452-63. [PubMed: 15383576]  [MGI Ref ID J:93735]

Felmy B; Songhet P; Slack EM; Muller AJ; Kremer M; Van Maele L; Cayet D; Heikenwalder M; Sirard JC; Hardt WD. 2013. NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium. PLoS One 8(10):e77204. [PubMed: 24143212]  [MGI Ref ID J:209119]

Feng HM; Walker DH. 2004. Mechanisms of immunity to Ehrlichia muris: a model of monocytotropic ehrlichiosis. Infect Immun 72(2):966-71. [PubMed: 14742542]  [MGI Ref ID J:87862]

Fernandes KS; Neto EH; Brito MM; Silva JS; Cunha FQ; Barja-Fidalgo C. 2008. Detrimental role of endogenous nitric oxide in host defence against Sporothrix schenckii. Immunology 123(4):469-79. [PubMed: 18194265]  [MGI Ref ID J:136580]

Fraszczak J; Trad M; Janikashvili N; Cathelin D; Lakomy D; Granci V; Morizot A; Audia S; Micheau O; Lagrost L; Katsanis E; Solary E; Larmonier N; Bonnotte B. 2010. Peroxynitrite-dependent killing of cancer cells and presentation of released tumor antigens by activated dendritic cells. J Immunol 184(4):1876-84. [PubMed: 20089706]  [MGI Ref ID J:159469]

Fukumura D; Gohongi T; Kadambi A; Izumi Y; Ang J; Yun CO; Buerk DG; Huang PL; Jain RK. 2001. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc Natl Acad Sci U S A 98(5):2604-9. [PubMed: 11226286]  [MGI Ref ID J:67870]

Ganley L; Babu S; Rajan TV. 2001. Course of Brugia malayi infection in C57BL/6J NOS2 +/+ and -/- mice. Exp Parasitol 98(1):35-43. [PubMed: 11426950]  [MGI Ref ID J:102684]

Gaur U; Roberts SC; Dalvi RP; Corraliza I; Ullman B; Wilson ME. 2007. An effect of parasite-encoded arginase on the outcome of murine cutaneous leishmaniasis. J Immunol 179(12):8446-53. [PubMed: 18056391]  [MGI Ref ID J:155195]

Gericke A; Goloborodko E; Sniatecki JJ; Steege A; Wojnowski L; Pfeiffer N. 2013. Contribution of nitric oxide synthase isoforms to cholinergic vasodilation in murine retinal arterioles. Exp Eye Res 109:60-6. [PubMed: 23434456]  [MGI Ref ID J:210420]

Ghosn EE; Russo M; Almeida SR. 2006. Nitric oxide-dependent killing of Cryptococcus neoformans by B-1-derived mononuclear phagocyte. J Leukoc Biol 80(1):36-44. [PubMed: 16670124]  [MGI Ref ID J:110472]

Gillman BM; Batchelder J; Flaherty P; Weidanz WP. 2004. Suppression of Plasmodium chabaudi parasitemia is independent of the action of reactive oxygen intermediates and/or nitric oxide. Infect Immun 72(11):6359-66. [PubMed: 15501765]  [MGI Ref ID J:93252]

Giordano D; Li C; Suthar MS; Draves KE; Ma DY; Gale M Jr; Clark EA. 2011. Nitric oxide controls an inflammatory-like Ly6C(hi)PDCA1+ DC subset that regulates Th1 immune responses. J Leukoc Biol 89(3):443-55. [PubMed: 21178115]  [MGI Ref ID J:170375]

Gobert AP; Cheng Y; Akhtar M; Mersey BD; Blumberg DR; Cross RK; Chaturvedi R; Drachenberg CB; Boucher JL; Hacker A; Casero RA Jr; Wilson KT. 2004. Protective role of arginase in a mouse model of colitis. J Immunol 173(3):2109-17. [PubMed: 15265947]  [MGI Ref ID J:92035]

Goldmann O; von Kockritz-Blickwede M; Holtje C; Chhatwal GS; Geffers R; Medina E. 2007. Transcriptome analysis of murine macrophages in response to infection with Streptococcus pyogenes reveals an unusual activation program. Infect Immun 75(8):4148-57. [PubMed: 17526748]  [MGI Ref ID J:123374]

Gomes SA; Rangel EB; Premer C; Dulce RA; Cao Y; Florea V; Balkan W; Rodrigues CO; Schally AV; Hare JM. 2013. S-nitrosoglutathione reductase (GSNOR) enhances vasculogenesis by mesenchymal stem cells. Proc Natl Acad Sci U S A 110(8):2834-9. [PubMed: 23288904]  [MGI Ref ID J:193262]

Gomez-Ambrosi J; Becerril S; Oroz P; Zabalza S; Rodriguez A; Muruzabal FJ; Archanco M; Gil MJ; Burrell MA; Fruhbeck G. 2004. Reduced adipose tissue mass and hypoleptinemia in iNOS deficient mice: effect of LPS on plasma leptin and adiponectin concentrations. FEBS Lett 577(3):351-6. [PubMed: 15556608]  [MGI Ref ID J:94571]

Gonzalez C; Cuvellier S; Hue-Beauvais C; Levi-Strauss M. 2003. Genetic control of non obese diabetic mice susceptibility to high-dose streptozotocin-induced diabetes. Diabetologia 46(9):1291-5. [PubMed: 12879252]  [MGI Ref ID J:95957]

Gorbunov NV; Kiang JG. 2009. Up-regulation of autophagy in small intestine Paneth cells in response to total-body gamma-irradiation. J Pathol 219(2):242-52. [PubMed: 19681094]  [MGI Ref ID J:152797]

Gramaglia I; Sobolewski P; Meays D; Contreras R; Nolan JP; Frangos JA; Intaglietta M; van der Heyde HC. 2006. Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria. Nat Med 12(12):1417-22. [PubMed: 17099710]  [MGI Ref ID J:129543]

Greenberg SS; Ouyang J; Zhao X; Parrish C; Nelson S; Giles TD. 1999. Effects of ethanol on neutrophil recruitment and lung host defense in nitric oxide synthase I and nitric oxide synthase II knockout mice. Alcohol Clin Exp Res 23(9):1435-45. [PubMed: 10512307]  [MGI Ref ID J:59745]

Guhring H; Gorig M; Ates M; Coste O; Zeilhofer HU; Pahl A; Rehse K; Brune K. 2000. Suppressed injury-induced rise in spinal prostaglandin E2 production and reduced early thermal hyperalgesia in iNOS-deficient mice. J Neurosci 20(17):6714-20. [PubMed: 10964977]  [MGI Ref ID J:64215]

Guo Y; Jones WK; Xuan YT; Tang XL; Bao W; Wu WJ; Han H; Laubach VE; Ping P; Yang Z; Qiu Y; Bolli R. 1999. The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene [see comments] Proc Natl Acad Sci U S A 96(20):11507-12. [PubMed: 10500207]  [MGI Ref ID J:57975]

Guthrie SM; Curtis LM; Mames RN; Simon GG; Grant MB; Scott EW. 2005. The nitric oxide pathway modulates hemangioblast activity of adult hematopoietic stem cells. Blood 105(5):1916-22. [PubMed: 15546953]  [MGI Ref ID J:98135]

Haag D; Zipper P; Westrich V; Karra D; Pfleger K; Toedt G; Blond F; Delhomme N; Hahn M; Reifenberger J; Reifenberger G; Lichter P. 2012. Nos2 inactivation promotes the development of medulloblastoma in Ptch1(+/-) mice by deregulation of Gap43-dependent granule cell precursor migration. PLoS Genet 8(3):e1002572. [PubMed: 22438824]  [MGI Ref ID J:183478]

Hamada T; Duarte S; Tsuchihashi S; Busuttil RW; Coito AJ. 2009. Inducible nitric oxide synthase deficiency impairs matrix metalloproteinase-9 activity and disrupts leukocyte migration in hepatic ischemia/reperfusion injury. Am J Pathol 174(6):2265-77. [PubMed: 19443702]  [MGI Ref ID J:148923]

Hampton TG; Amende I; Fong J; Laubach VE; Li J; Metais C; Simons M. 2000. Basic FGF reduces stunning via a NOS2-dependent pathway in coronary-perfused mouse hearts. Am J Physiol Heart Circ Physiol 279(1):H260-8. [PubMed: 10899065]  [MGI Ref ID J:107850]

Hardiman KM; Lindsey JR; Matalon S. 2001. Lack of amiloride-sensitive transport across alveolar and respiratory epithelium of iNOS(-/-) mice in vivo. Am J Physiol Lung Cell Mol Physiol 281(3):L722-31. [PubMed: 11504701]  [MGI Ref ID J:71505]

Hegazi RA; Rao KN; Mayle A; Sepulveda AR; Otterbein LE; Plevy SE. 2005. Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway. J Exp Med 202(12):1703-13. [PubMed: 16365149]  [MGI Ref ID J:118826]

Hernandez-Cuellar E; Tsuchiya K; Hara H; Fang R; Sakai S; Kawamura I; Akira S; Mitsuyama M. 2012. Cutting edge: nitric oxide inhibits the NLRP3 inflammasome. J Immunol 189(11):5113-7. [PubMed: 23100513]  [MGI Ref ID J:190677]

Hertz CJ; Mansfield JM. 1999. IFN-gamma-dependent nitric oxide production is not linked to resistance in experimental African trypanosomiasis. Cell Immunol 192(1):24-32. [PubMed: 10066343]  [MGI Ref ID J:114251]

Hervera A; Leanez S; Negrete R; Motterlini R; Pol O. 2012. Carbon monoxide reduces neuropathic pain and spinal microglial activation by inhibiting nitric oxide synthesis in mice. PLoS One 7(8):e43693. [PubMed: 22928017]  [MGI Ref ID J:191571]

Hickman-Davis JM; Wang Z; Fierro-Perez GA; Chess PR; Page GP; Matalon S; Notter RH. 2007. Surfactant dysfunction in SP-A-/- and iNOS-/- mice with mycoplasma infection. Am J Respir Cell Mol Biol 36(1):103-13. [PubMed: 16917077]  [MGI Ref ID J:130520]

Hoang T; Choi DK; Nagai M; Wu DC; Nagata T; Prou D; Wilson GL; Vila M; Jackson-Lewis V; Dawson VL; Dawson TM; Chesselet MF; Przedborski S. 2009. Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease. Free Radic Biol Med 47(7):1049-56. [PubMed: 19616617]  [MGI Ref ID J:152538]

Hokari R; Kato S; Matsuzaki K; Kuroki M; Iwai A; Kawaguchi A; Nagao S; Miyahara T; Itoh K; Sekizuka E; Nagata H; Ishii H; Miura S. 2001. Reduced sensitivity of inducible nitric oxide synthase-deficient mice to chronic colitis. Free Radic Biol Med 31(2):153-63. [PubMed: 11440827]  [MGI Ref ID J:70811]

Hollenberg SM; Broussard M; Osman J; Parrillo JE. 2000. Increased microvascular reactivity and improved mortality in septic mice lacking inducible nitric oxide synthase. Circ Res 86(7):774-8. [PubMed: 10764411]  [MGI Ref ID J:110288]

Houpt ER; Glembocki DJ; Obrig TG; Moskaluk CA; Lockhart LA; Wright RL; Seaner RM; Keepers TR; Wilkins TD; Petri WA Jr. 2002. The mouse model of amebic colitis reveals mouse strain susceptibility to infection and exacerbation of disease by CD4+ T cells. J Immunol 169(8):4496-503. [PubMed: 12370386]  [MGI Ref ID J:120012]

Hromatka BS; Noble SM; Johnson AD. 2005. Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence. Mol Biol Cell 16(10):4814-26. [PubMed: 16030247]  [MGI Ref ID J:106530]

Hsieh SH; Lin JS; Huang JH; Wu SY; Chu CL; Kung JT; Wu-Hsieh BA. 2011. Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis. Infect Immun 79(11):4493-502. [PubMed: 21911464]  [MGI Ref ID J:177771]

Huang B; Pan PY; Li Q; Sato AI; Levy DE; Bromberg J; Divino CM; Chen SH. 2006. Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res 66(2):1123-31. [PubMed: 16424049]  [MGI Ref ID J:106544]

Hussain MB; Hobbs AJ; MacAllister RJ. 1999. Autoregulation of nitric oxide-soluble guanylate cyclase-cyclic GMP signalling in mouse thoracic aorta. Br J Pharmacol 128(5):1082-8. [PubMed: 10556946]  [MGI Ref ID J:59681]

Hussain SP; He P; Subleski J; Hofseth LJ; Trivers GE; Mechanic L; Hofseth AB; Bernard M; Schwank J; Nguyen G; Mathe E; Djurickovic D; Haines D; Weiss J; Back T; Gruys E; Laubach VE; Wiltrout RH; Harris CC. 2008. Nitric oxide is a key component in inflammation-accelerated tumorigenesis. Cancer Res 68(17):7130-6. [PubMed: 18757428]  [MGI Ref ID J:138926]

Hussain SP; Trivers GE; Hofseth LJ; He P; Shaikh I; Mechanic LE; Doja S; Jiang W; Subleski J; Shorts L; Haines D; Laubach VE; Wiltrout RH; Djurickovic D; Harris CC. 2004. Nitric oxide, a mediator of inflammation, suppresses tumorigenesis. Cancer Res 64(19):6849-53. [PubMed: 15466171]  [MGI Ref ID J:93662]

Hutchinson D; Ho V; Dodd M; Dawson HN; Zumwalt AC; Schmitt D; Colton CA. 2007. Quantitative measurement of postural sway in mouse models of human neurodegenerative disease. Neuroscience 148(4):825-32. [PubMed: 17764851]  [MGI Ref ID J:128390]

Ii M; Nishimura H; Iwakura A; Wecker A; Eaton E; Asahara T; Losordo DW. 2005. Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via 'imported' nitric oxide synthase activity. Circulation 111(9):1114-20. [PubMed: 15723985]  [MGI Ref ID J:108997]

Into T; Inomata M; Nakashima M; Shibata K; Hacker H; Matsushita K. 2008. Regulation of MyD88-dependent signaling events by S nitrosylation retards toll-like receptor signal transduction and initiation of acute-phase immune responses. Mol Cell Biol 28(4):1338-47. [PubMed: 18086890]  [MGI Ref ID J:132654]

Isaksson J; Farooque M; Olsson Y. 2005. Improved functional outcome after spinal cord injury in iNOS-deficient mice. Spinal Cord 43(3):167-70. [PubMed: 15520837]  [MGI Ref ID J:110081]

Itzhak Y; Martin JL; Ali SF. 1999. Methamphetamine- and 1-methyl-4-phenyl- 1,2,3, 6-tetrahydropyridine-induced dopaminergic neurotoxicity in inducible nitric oxide synthase-deficient mice. Synapse 34(4):305-12. [PubMed: 10529724]  [MGI Ref ID J:59707]

Iwakiri Y; Cadelina G; Sessa WC; Groszmann RJ. 2002. Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension. Am J Physiol Gastrointest Liver Physiol 283(5):G1074-81. [PubMed: 12381520]  [MGI Ref ID J:108056]

Jantsch J; Schatz V; Friedrich D; Schroder A; Kopp C; Siegert I; Maronna A; Wendelborn D; Linz P; Binger KJ; Gebhardt M; Heinig M; Neubert P; Fischer F; Teufel S; David JP; Neufert C; Cavallaro A; Rakova N; Kuper C; Beck FX; Neuhofer W; Muller DN; Schuler G; Uder M; Bogdan C; Luft FC; Titze J. 2015. Cutaneous Na+ storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense. Cell Metab 21(3):493-501. [PubMed: 25738463]  [MGI Ref ID J:220700]

Jayaraman P; Parikh F; Lopez-Rivera E; Hailemichael Y; Clark A; Ma G; Cannan D; Ramacher M; Kato M; Overwijk WW; Chen SH; Umansky VY; Sikora AG. 2012. Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release. J Immunol 188(11):5365-76. [PubMed: 22529296]  [MGI Ref ID J:188746]

Jones SP; Greer JJ; Ware PD; Yang J; Walsh K; Lefer DJ. 2005. Deficiency of iNOS does not attenuate severe congestive heart failure in mice. Am J Physiol Heart Circ Physiol 288(1):H365-70. [PubMed: 15319210]  [MGI Ref ID J:95577]

Jones SP; Trocha SD; Lefer DJ. 2001. Cardioprotective actions of endogenous IL-10 are independent of iNOS. Am J Physiol Heart Circ Physiol 281(1):H48-52. [PubMed: 11406467]  [MGI Ref ID J:70292]

Joo JD; Kim M; Horst P; Kim J; D'Agati VD; Emala CW Sr; Lee HT. 2007. Acute and delayed renal protection against renal ischemia and reperfusion injury with A1 adenosine receptors. Am J Physiol Renal Physiol 293(6):F1847-57. [PubMed: 17928414]  [MGI Ref ID J:127544]

Kahl KG; Schmidt HH; Jung S; Sherman P; Toyka KV; Zielasek J. 2004. Experimental autoimmune encephalomyelitis in mice with a targeted deletion of the inducible nitric oxide synthase gene: increased T-helper 1 response. Neurosci Lett 358(1):58-62. [PubMed: 15016434]  [MGI Ref ID J:88809]

Kalns J; Scruggs J; Millenbaugh N; Vivekananda J; Shealy D; Eggers J; Kiel J. 2002. TNF Receptor 1, IL-1 Receptor, and iNOS Genetic Knockout Mice Are Not Protected from Anthrax Infection. Biochem Biophys Res Commun 292(1):41-4. [PubMed: 11890668]  [MGI Ref ID J:75694]

Kan MJ; Lee JE; Wilson JG; Everhart AL; Brown CM; Hoofnagle AN; Jansen M; Vitek MP; Gunn MD; Colton CA. 2015. Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. J Neurosci 35(15):5969-82. [PubMed: 25878270]  [MGI Ref ID J:221677]

Kania G; Siegert S; Behnke S; Prados-Rosales R; Casadevall A; Luscher TF; Luther SA; Kopf M; Eriksson U; Blyszczuk P. 2013. Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis. Circulation 127(23):2285-94. [PubMed: 23671208]  [MGI Ref ID J:211390]

Kenyon NJ; van der Vliet A; Schock BC; Okamoto T; McGrew GM; Last JA. 2002. Susceptibility to ozone-induced acute lung injury in iNOS-deficient mice. Am J Physiol Lung Cell Mol Physiol 282(3):L540-5. [PubMed: 11839550]  [MGI Ref ID J:75613]

Kim HA; Kim SH; Ko HM; Choi JH; Kim KJ; Oh SH; Cho KO; Choi IW; Im SY. 2008. Nitric oxide plays a key role in the platelet-activating factor-induced enhancement of resistance against systemic candidiasis. Immunology 124(3):428-35. [PubMed: 18397269]  [MGI Ref ID J:138455]

Kirksey MA; Tischler AD; Simeone R; Hisert KB; Uplekar S; Guilhot C; McKinney JD. 2011. Spontaneous Phthiocerol Dimycocerosate-Deficient Variants of Mycobacterium tuberculosis Are Susceptible to Gamma Interferon-Mediated Immunity. Infect Immun 79(7):2829-38. [PubMed: 21576344]  [MGI Ref ID J:173476]

Kisley LR; Barrett BS; Bauer AK; Dwyer-Nield LD; Barthel B; Meyer AM; Thompson DC; Malkinson AM. 2002. Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis. Cancer Res 62(23):6850-6. [PubMed: 12460898]  [MGI Ref ID J:80325]

Kitayama J; Faraci FM; Gunnett CA; Heistad DD. 2006. Impairment of dilator responses of cerebral arterioles during diabetes mellitus: role of inducible NO synthase. Stroke 37(8):2129-33. [PubMed: 16809563]  [MGI Ref ID J:135707]

Kleeberger SR; Reddy SP; Zhang LY; Cho HY; Jedlicka AE. 2001. Toll-like receptor 4 mediates ozone-induced murine lung hyperpermeability via inducible nitric oxide synthase. Am J Physiol Lung Cell Mol Physiol 280(2):L326-33. [PubMed: 11159012]  [MGI Ref ID J:108671]

Klingstrom J; Akerstrom S; Hardestam J; Stoltz M; Simon M; Falk KI; Mirazimi A; Rottenberg M; Lundkvist A. 2006. Nitric oxide and peroxynitrite have different antiviral effects against hantavirus replication and free mature virions. Eur J Immunol 36(10):2649-57. [PubMed: 16955520]  [MGI Ref ID J:118085]

Knotek M; Rogachev B; Wang W; Ecder T; Melnikov V; Gengaro PE; Esson M; Edelstein CL; Dinarello CA; Schrier RW. 2001. Endotoxemic renal failure in mice: Role of tumor necrosis factor independent of inducible nitric oxide synthase. Kidney Int 59(6):2243-9. [PubMed: 11380827]  [MGI Ref ID J:104003]

Knudsen L; Atochina-Vasserman EN; Guo CJ; Scott PA; Haenni B; Beers MF; Ochs M; Gow AJ. 2014. NOS2 is critical to the development of emphysema in Sftpd deficient mice but does not affect surfactant homeostasis. PLoS One 9(1):e85722. [PubMed: 24465666]  [MGI Ref ID J:212338]

Ko J; Gendron-Fitzpatrick A; Splitter GA. 2002. Susceptibility of IFN regulatory factor-1 and IFN consensus sequence binding protein-deficient mice to brucellosis. J Immunol 168(5):2433-40. [PubMed: 11859135]  [MGI Ref ID J:74725]

Kotamraju S; Matalon S; Matsunaga T; Shang T; Hickman-Davis JM; Kalyanaraman B. 2006. Upregulation of immunoproteasomes by nitric oxide: Potential antioxidative mechanism in endothelial cells. Free Radic Biol Med 40(6):1034-44. [PubMed: 16540399]  [MGI Ref ID J:107075]

Kozak W; Kozak A. 2003. Genetic Models in Applied Physiology. Differential role of nitric oxide synthase isoforms in fever of different etiologies: studies using Nos gene-deficient mice. J Appl Physiol 94(6):2534-44. [PubMed: 12562678]  [MGI Ref ID J:103018]

Krieglstein CF; Anthoni C; Cerwinka WH; Stokes KY; Russell J; Grisham MB; Granger DN. 2007. Role of blood- and tissue-associated inducible nitric-oxide synthase in colonic inflammation. Am J Pathol 170(2):490-6. [PubMed: 17255317]  [MGI Ref ID J:117890]

Krieglstein CF; Cerwinka WH; Laroux FS; Salter JW; Russell JM; Schuermann G; Grisham MB; Ross CR; Granger DN. 2001. Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide. J Exp Med 194(9):1207-18. [PubMed: 11696587]  [MGI Ref ID J:134388]

Kuhlencordt PJ; Chen J; Han F; Astern J; Huang PL. 2001. Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice. Circulation 103(25):3099-104. [PubMed: 11425775]  [MGI Ref ID J:103350]

Kummer MP; Hermes M; Delekarte A; Hammerschmidt T; Kumar S; Terwel D; Walter J; Pape HC; Konig S; Roeber S; Jessen F; Klockgether T; Korte M; Heneka MT. 2011. Nitration of tyrosine 10 critically enhances amyloid beta aggregation and plaque formation. Neuron 71(5):833-44. [PubMed: 21903077]  [MGI Ref ID J:176667]

Kurtz S; McKinnon KP; Runge MS; Ting JP; Braunstein M. 2006. The SecA2 secretion factor of Mycobacterium tuberculosis promotes growth in macrophages and inhibits the host immune response. Infect Immun 74(12):6855-64. [PubMed: 17030572]  [MGI Ref ID J:116072]

LaCasse CJ; Janikashvili N; Larmonier CB; Alizadeh D; Hanke N; Kartchner J; Situ E; Centuori S; Har-Noy M; Bonnotte B; Katsanis E; Larmonier N. 2011. Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-gamma-dependent mechanism. J Immunol 187(12):6310-7. [PubMed: 22075702]  [MGI Ref ID J:180408]

Lai JF; Zindl CL; Duffy LB; Atkinson TP; Jung YW; van Rooijen N; Waites KB; Krause DC; Chaplin DD. 2010. Critical role of macrophages and their activation via MyD88-NFkappaB signaling in lung innate immunity to Mycoplasma pneumoniae. PLoS One 5(12):e14417. [PubMed: 21203444]  [MGI Ref ID J:168336]

Lamon BD; Upmacis RK; Deeb RS; Koyuncu H; Hajjar DP. 2010. Inducible nitric oxide synthase gene deletion exaggerates MAPK-mediated cyclooxygenase-2 induction by inflammatory stimuli. Am J Physiol Heart Circ Physiol 299(3):H613-23. [PubMed: 20543082]  [MGI Ref ID J:164511]

Landgraf RG; Russo M; Jancar S. 2005. Acute inhibition of inducible nitric oxide synthase but not its absence suppresses asthma-like responses. Eur J Pharmacol 518(2-3):212-20. [PubMed: 16023634]  [MGI Ref ID J:106361]

Laubach VE; Foley PL; Shockey KS; Tribble CG; Kron IL. 1998. Protective roles of nitric oxide and testosterone in endotoxemia: evidence from NOS-2-deficient mice. Am J Physiol 275(6 Pt 2):H2211-8. [PubMed: 9843821]  [MGI Ref ID J:51564]

Leal EC; Manivannan A; Hosoya K; Terasaki T; Cunha-Vaz J; Ambrosio AF; Forrester JV. 2007. Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. Invest Ophthalmol Vis Sci 48(11):5257-65. [PubMed: 17962481]  [MGI Ref ID J:127155]

Lee MR; Seo GY; Kim YM; Kim PH. 2011. iNOS potentiates mouse Ig isotype switching through AID expression. Biochem Biophys Res Commun 410(3):602-7. [PubMed: 21684254]  [MGI Ref ID J:174949]

Lee YS; Li N; Shin S; Jun HS. 2009. Role of nitric oxide in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice. J Virol 83(16):8004-11. [PubMed: 19535454]  [MGI Ref ID J:151516]

Lefer DJ; Jones SP; Girod WG; Baines A; Grisham MB; Cockrell AS; Huang PL; Scalia R. 1999. Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice. Am J Physiol 276(6 Pt 2):H1943-50. [PubMed: 10362674]  [MGI Ref ID J:55936]

Lewis CJ; Cobb BA. 2010. Carbohydrate oxidation acidifies endosomes, regulating antigen processing and TLR9 signaling. J Immunol 184(7):3789-800. [PubMed: 20200279]  [MGI Ref ID J:160075]

Li D; Laubach VE; Johns RA. 2001. Upregulation of lung soluble guanylate cyclase during chronic hypoxia is prevented by deletion of eNOS. Am J Physiol Lung Cell Mol Physiol 281(2):L369-76. [PubMed: 11435211]  [MGI Ref ID J:108269]

Li D; Shin JH; Duan D. 2011. iNOS Ablation Does Not Improve Specific Force of the Extensor Digitorum Longus Muscle in Dystrophin-Deficient mdx4cv Mice. PLoS One 6(6):e21618. [PubMed: 21738735]  [MGI Ref ID J:174763]

Li E; Zhou P; Singer SM. 2006. Neuronal nitric oxide synthase is necessary for elimination of Giardia lamblia infections in mice. J Immunol 176(1):516-21. [PubMed: 16365445]  [MGI Ref ID J:126256]

Li G; Veenstra AA; Talahalli RR; Wang X; Gubitosi-Klug RA; Sheibani N; Kern TS. 2012. Marrow-derived cells regulate the development of early diabetic retinopathy and tactile allodynia in mice. Diabetes 61(12):3294-303. [PubMed: 22923475]  [MGI Ref ID J:208497]

Li J; Baud O; Vartanian T; Volpe JJ; Rosenberg PA. 2005. Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes. Proc Natl Acad Sci U S A 102(28):9936-41. [PubMed: 15998743]  [MGI Ref ID J:99857]

Li W; Ren G; Huang Y; Su J; Han Y; Li J; Chen X; Cao K; Chen Q; Shou P; Zhang L; Yuan ZR; Roberts AI; Shi S; Le AD; Shi Y. 2012. Mesenchymal stem cells: a double-edged sword in regulating immune responses. Cell Death Differ 19(9):1505-13. [PubMed: 22421969]  [MGI Ref ID J:204801]

Li X; McKinstry KK; Swain SL; Dalton DK. 2007. IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals. J Immunol 179(2):939-49. [PubMed: 17617585]  [MGI Ref ID J:149401]

Liao S; Cheng G; Conner DA; Huang Y; Kucherlapati RS; Munn LL; Ruddle NH; Jain RK; Fukumura D; Padera TP. 2011. Impaired lymphatic contraction associated with immunosuppression. Proc Natl Acad Sci U S A 108(46):18784-9. [PubMed: 22065738]  [MGI Ref ID J:180179]

Libby RT; Howell GR; Pang IH; Savinova OV; Mehalow AK; Barter JW; Smith RS; Clark AF; John SW. 2007. Inducible nitric oxide synthase, Nos2, does not mediate optic neuropathy and retinopathy in the DBA/2J glaucoma model. BMC Neurosci 8:108. [PubMed: 18093296]  [MGI Ref ID J:130816]

Liberatore GT; Jackson-Lewis V; Vukosavic S; Mandir AS; Vila M; McAuliffe WG; Dawson VL; Dawson TM; Przedborski S. 1999. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease [see comments] Nat Med 5(12):1403-9. [PubMed: 10581083]  [MGI Ref ID J:58724]

Lichten LA; Liuzzi JP; Cousins RJ. 2009. Interleukin-1beta contributes via nitric oxide to the upregulation and functional activity of the zinc transporter Zip14 (Slc39a14) in murine hepatocytes. Am J Physiol Gastrointest Liver Physiol 296(4):G860-7. [PubMed: 19179618]  [MGI Ref ID J:149697]

Lidington D; Li F; Tyml K. 2007. Deletion of neuronal NOS prevents impaired vasodilation in septic mouse skeletal muscle. Cardiovasc Res 74(1):151-8. [PubMed: 17258180]  [MGI Ref ID J:119500]

Lindgren H; Stenmark S; Chen W; Tarnvik A; Sjostedt A. 2004. Distinct roles of reactive nitrogen and oxygen species to control infection with the facultative intracellular bacterium Francisella tularensis. Infect Immun 72(12):7172-82. [PubMed: 15557642]  [MGI Ref ID J:94215]

Ling W; Zhang J; Yuan Z; Ren G; Zhang L; Chen X; Rabson AB; Roberts AI; Wang Y; Shi Y. 2014. Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment. Cancer Res 74(5):1576-87. [PubMed: 24452999]  [MGI Ref ID J:208149]

Ling YM; Shaw MH; Ayala C; Coppens I; Taylor GA; Ferguson DJ; Yap GS. 2006. Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. J Exp Med 203(9):2063-71. [PubMed: 16940170]  [MGI Ref ID J:124556]

Liu YH; Carretero OA; Cingolani OH; Liao TD; Sun Y; Xu J; Li LY; Pagano PJ; Yang JJ; Yang XP. 2005. Role of inducible nitric oxide synthase in cardiac function and remodeling in mice with heart failure due to myocardial infarction. Am J Physiol Heart Circ Physiol 289(6):H2616-23. [PubMed: 16055518]  [MGI Ref ID J:104749]

Lizarbe TR; Tarin C; Gomez M; Lavin B; Aracil E; Orte LM; Zaragoza C. 2009. Nitric Oxide Induces the Progression of Abdominal Aortic Aneurysms through the Matrix Metalloproteinase Inducer EMMPRIN. Am J Pathol :. [PubMed: 19779140]  [MGI Ref ID J:152751]

Lu G; Zhang R; Geng S; Peng L; Jayaraman P; Chen C; Xu F; Yang J; Li Q; Zheng H; Shen K; Wang J; Liu X; Wang W; Zheng Z; Qi CF; Si C; He JC; Liu K; Lira SA; Sikora AG; Li L; Xiong H. 2015. Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization. Nat Commun 6:6676. [PubMed: 25813085]  [MGI Ref ID J:221863]

Lue Y; Sinha Hikim AP; Wang C; Leung A; Swerdloff RS. 2003. Functional role of inducible nitric oxide synthase in the induction of male germ cell apoptosis, regulation of sperm number, and determination of testes size: evidence from null mutant mice. Endocrinology 144(7):3092-100. [PubMed: 12810565]  [MGI Ref ID J:84347]

Luiking YC; Hallemeesch MM; Lamers WH; Deutz NE. 2005. NOS3 is involved in the increased protein and arginine metabolic response in muscle during early endotoxemia in mice. Am J Physiol Endocrinol Metab 288(6):E1258-64. [PubMed: 15644457]  [MGI Ref ID J:98378]

Luiking YC; Hallemeesch MM; Lamers WH; Deutz NE. 2005. The role of NOS2 and NOS3 in renal protein and arginine metabolism during early endotoxemia in mice. Am J Physiol Renal Physiol 288(4):F816-22. [PubMed: 15547116]  [MGI Ref ID J:97198]

Lush CW; Cepinskas G; Sibbald WJ; Kvietys PR. 2001. Endothelial E- and P-selectin expression in iNOS- deficient mice exposed to polymicrobial sepsis. Am J Physiol Gastrointest Liver Physiol 280(2):G291-7. [PubMed: 11208553]  [MGI Ref ID J:68060]

Maa MC; Chang MY; Li J; Li YY; Hsieh MY; Yang CJ; Chen YJ; Li Y; Chen HC; Cheng WE; Hsieh CY; Cheng CW; Leu TH. 2011. The iNOS/Src/FAK axis is critical in Toll-like receptor-mediated cell motility in macrophages. Biochim Biophys Acta 1813(1):136-47. [PubMed: 20849883]  [MGI Ref ID J:170208]

Mahnke A; Meier RJ; Schatz V; Hofmann J; Castiglione K; Schleicher U; Wolfbeis OS; Bogdan C; Jantsch J. 2014. Hypoxia in Leishmania major Skin Lesions Impairs the NO-Dependent Leishmanicidal Activity of Macrophages. J Invest Dermatol 134(9):2339-46. [PubMed: 24583949]  [MGI Ref ID J:212841]

Malan D; Ji GJ; Schmidt A; Addicks K; Hescheler J; Levi RC; Bloch W; Fleischmann BK. 2004. Nitric oxide, a key signaling molecule in the murine early embryonic heart. FASEB J 18(10):1108-10. [PubMed: 15132985]  [MGI Ref ID J:118469]

Malik M; Jividen K; Padmakumar VC; Cataisson C; Li L; Lee J; Howard OM; Yuspa SH. 2012. Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation. Proc Natl Acad Sci U S A 109(16):6130-5. [PubMed: 22474389]  [MGI Ref ID J:183611]

Marigo I; Bosio E; Solito S; Mesa C; Fernandez A; Dolcetti L; Ugel S; Sonda N; Bicciato S; Falisi E; Calabrese F; Basso G; Zanovello P; Cozzi E; Mandruzzato S; Bronte V. 2010. Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. Immunity 32(6):790-802. [PubMed: 20605485]  [MGI Ref ID J:162002]

Marjanovic JA; Stojanovic A; Brovkovych VM; Skidgel RA; Du X. 2008. Signaling-mediated functional activation of inducible nitric-oxide synthase and its role in stimulating platelet activation. J Biol Chem 283(43):28827-34. [PubMed: 18753139]  [MGI Ref ID J:142549]

Marriott HM; Hellewell PG; Cross SS; Ince PG; Whyte MK; Dockrell DH. 2006. Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia. J Immunol 177(9):6480-8. [PubMed: 17056580]  [MGI Ref ID J:140505]

Martin LJ; Chen K; Liu Z. 2005. Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation. J Neurosci 25(27):6449-59. [PubMed: 16000635]  [MGI Ref ID J:99428]

Mascia F; Lam G; Keith C; Garber C; Steinberg SM; Kohn E; Yuspa SH. 2013. Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy. Sci Transl Med 5(199):199ra110. [PubMed: 23966299]  [MGI Ref ID J:213463]

Mastroeni P; Vazquez-Torres A; Fang FC; Xu Y; Khan S; Hormaeche CE; Dougan G. 2000. Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. II. Effects on microbial proliferation and host survival in vivo. J Exp Med 192(2):237-48. [PubMed: 10899910]  [MGI Ref ID J:63489]

Mathe E; Nguyen GH; Funamizu N; He P; Moake M; Croce CM; Hussain SP. 2012. Inflammation regulates microRNA expression in cooperation with p53 and nitric oxide. Int J Cancer 131(3):760-5. [PubMed: 22042537]  [MGI Ref ID J:186121]

Mayr U; Zou Y; Zhang Z; Dietrich H; Hu Y; Xu Q. 2006. Accelerated arteriosclerosis of vein grafts in inducible NO synthase(-/-) mice is related to decreased endothelial progenitor cell repair. Circ Res 98(3):412-20. [PubMed: 16385078]  [MGI Ref ID J:118879]

McKenna KC; Beatty KM; Scherder RC; Li F; Liu H; Chen AF; Ghosh A; Stuehr DJ. 2013. Ascorbate in aqueous humor augments nitric oxide production by macrophages. J Immunol 190(2):556-64. [PubMed: 23241881]  [MGI Ref ID J:191191]

McKim SE; Gabele E; Isayama F; Lambert JC; Tucker LM; Wheeler MD; Connor HD; Mason RP; Doll MA; Hein DW; Arteel GE. 2003. Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice. Gastroenterology 125(6):1834-44. [PubMed: 14724835]  [MGI Ref ID J:86852]

McKinnon RL; Lidington D; Bolon M; Ouellette Y; Kidder GM; Tyml K. 2006. Reduced arteriolar conducted vasoconstriction in septic mouse cremaster muscle is mediated by nNOS-derived NO. Cardiovasc Res 69(1):236-44. [PubMed: 16226732]  [MGI Ref ID J:112791]

Merkel MJ; Liu L; Cao Z; Packwood W; Hurn PD; Van Winkle DM. 2008. Estradiol abolishes reduction in cell death by the opioid agonist Met5-enkephalin after oxygen glucose deprivation in isolated cardiomyocytes from both sexes. Am J Physiol Heart Circ Physiol 295(1):H409-15. [PubMed: 18502904]  [MGI Ref ID J:138205]

Mestriner FL; Spiller F; Laure HJ; Souto FO; Tavares-Murta BM; Rosa JC; Basile-Filho A; Ferreira SH; Greene LJ; Cunha FQ. 2007. Acute-phase protein alpha-1-acid glycoprotein mediates neutrophil migration failure in sepsis by a nitric oxide-dependent mechanism. Proc Natl Acad Sci U S A 104(49):19595-600. [PubMed: 18048324]  [MGI Ref ID J:128489]

Mgbemena V; Segovia JA; Chang TH; Tsai SY; Cole GT; Hung CY; Bose S. 2012. Transactivation of inducible nitric oxide synthase gene by Kruppel-like factor 6 regulates apoptosis during influenza A virus infection. J Immunol 189(2):606-15. [PubMed: 22711891]  [MGI Ref ID J:189798]

Michael SL; Mayeux PR; Bucci TJ; Warbritton AR; Irwin LK; Pumford NR; Hinson JA. 2001. Acetaminophen-induced hepatotoxicity in mice lacking inducible nitric oxide synthase activity. Nitric Oxide 5(5):432-41. [PubMed: 11587558]  [MGI Ref ID J:72352]

Miguel RD; Cherpes TL; Watson LJ; McKenna KC. 2010. CTL Induction of Tumoricidal Nitric Oxide Production by Intratumoral Macrophages Is Critical for Tumor Elimination. J Immunol 185(11):6706-18. [PubMed: 21041723]  [MGI Ref ID J:166136]

Mishra BB; Rathinam VA; Martens GW; Martinot AJ; Kornfeld H; Fitzgerald KA; Sassetti CM. 2013. Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1beta. Nat Immunol 14(1):52-60. [PubMed: 23160153]  [MGI Ref ID J:191074]

Mittal R; Gonzalez-Gomez I; Goth KA; Prasadarao NV. 2010. Inhibition of inducible nitric oxide controls pathogen load and brain damage by enhancing phagocytosis of Escherichia coli K1 in neonatal meningitis. Am J Pathol 176(3):1292-305. [PubMed: 20093483]  [MGI Ref ID J:158359]

Miyazawa M; Suzuki H; Masaoka T; Kai A; Suematsu M; Nagata H; Miura S; Ishii H. 2003. Suppressed apoptosis in the inflamed gastric mucosa of Helicobacter pylori-colonized iNOS-knockout mice. Free Radic Biol Med 34(12):1621-30. [PubMed: 12788482]  [MGI Ref ID J:119415]

Moayeri M; Crown D; Newman ZL; Okugawa S; Eckhaus M; Cataisson C; Liu S; Sastalla I; Leppla SH. 2010. Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment. PLoS Pathog 6(12):e1001222. [PubMed: 21170303]  [MGI Ref ID J:168096]

Moayeri M; Martinez NW; Wiggins J; Young HA; Leppla SH. 2004. Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity. Infect Immun 72(8):4439-47. [PubMed: 15271901]  [MGI Ref ID J:91775]

Moens AL; Leyton-Mange JS; Niu X; Yang R; Cingolani O; Arkenbout EK; Champion HC; Bedja D; Gabrielson KL; Chen J; Xia Y; Hale AB; Channon KM; Halushka MK; Barker N; Wuyts FL; Kaminski PM; Wolin MS; Kass DA; Barouch LA. 2009. Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor. J Mol Cell Cardiol 47(5):576-85. [PubMed: 19766235]  [MGI Ref ID J:155006]

Montezuma K; Biojone C; Lisboa SF; Cunha FQ; Guimaraes FS; Joca SR. 2012. Inhibition of iNOS induces antidepressant-like effects in mice: pharmacological and genetic evidence. Neuropharmacology 62(1):485-91. [PubMed: 21939674]  [MGI Ref ID J:183566]

Moore ZW; Hui DY. 2005. Apolipoprotein E inhibition of vascular hyperplasia and neointima formation requires inducible nitric oxide synthase. J Lipid Res 46(10):2083-90. [PubMed: 16061951]  [MGI Ref ID J:104724]

Moraes JC; Amaral ME; Picardi PK; Calegari VC; Romanatto T; Bermudez-Echeverry M; Chiavegatto S; Saad MJ; Velloso LA. 2006. Inducible-NOS but not neuronal-NOS participate in the acute effect of TNF-alpha on hypothalamic insulin-dependent inhibition of food intake. FEBS Lett 580(19):4625-31. [PubMed: 16876161]  [MGI Ref ID J:112153]

Morton J; Coles B; Wright K; Gallimore A; Morrow JD; Terry ES; Anning PB; Morgan BP; Dioszeghy V; Kuhn H; Chaitidis P; Hobbs AJ; Jones SA; O'Donnell VB. 2008. Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFNgamma-dependent iNOS expression in the vasculature of healthy mice. Blood 111(10):5187-94. [PubMed: 18281503]  [MGI Ref ID J:135580]

Mota BE; Gallardo-Romero N; Trindade G; Keckler MS; Karem K; Carroll D; Campos MA; Vieira LQ; da Fonseca FG; Ferreira PC; Bonjardim CA; Damon IK; Kroon EG. 2011. Adverse Events Post Smallpox-Vaccination: Insights from Tail Scarification Infection in Mice with Vaccinia virus. PLoS One 6(4):e18924. [PubMed: 21526210]  [MGI Ref ID J:172270]

Myers L; Croft M; Kwon BS; Mittler RS; Vella AT. 2005. Peptide-specific CD8 T regulatory cells use IFN-gamma to elaborate TGF-beta-based suppression. J Immunol 174(12):7625-32. [PubMed: 15944263]  [MGI Ref ID J:100786]

Naghashpour M; Dahl G. 2000. Relaxation of myometrium by calcitonin gene-related peptide is independent of nitric oxide synthase activity in mouse uterus. Biol Reprod 63(5):1421-7. [PubMed: 11058547]  [MGI Ref ID J:108667]

Nam KT; Oh SY; Ahn B; Kim YB; Jang DD; Yang KH; Hahm KB; Kim DY. 2004. Decreased Helicobacter pylori associated gastric carcinogenesis in mice lacking inducible nitric oxide synthase. Gut 53(9):1250-5. [PubMed: 15306579]  [MGI Ref ID J:92904]

Naura AS; Zerfaoui M; Kim H; Abd Elmageed ZY; Rodriguez PC; Hans CP; Ju J; Errami Y; Park J; Ochoa AC; Boulares AH. 2010. Requirement for inducible nitric oxide synthase in chronic allergen exposure-induced pulmonary fibrosis but not inflammation. J Immunol 185(5):3076-85. [PubMed: 20668217]  [MGI Ref ID J:163265]

Nemeth K; Leelahavanichkul A; Yuen PS; Mayer B; Parmelee A; Doi K; Robey PG; Leelahavanichkul K; Koller BH; Brown JM; Hu X; Jelinek I; Star RA; Mezey E. 2009. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 15(1):42-9. [PubMed: 19098906]  [MGI Ref ID J:146566]

Niedbala W; Alves-Filho JC; Fukada SY; Vieira SM; Mitani A; Sonego F; Mirchandani A; Nascimento DC; Cunha FQ; Liew FY. 2011. Regulation of type 17 helper T-cell function by nitric oxide during inflammation. Proc Natl Acad Sci U S A 108(22):9220-5. [PubMed: 21576463]  [MGI Ref ID J:173232]

Nishida M; Ogushi M; Suda R; Toyotaka M; Saiki S; Kitajima N; Nakaya M; Kim KM; Ide T; Sato Y; Inoue K; Kurose H. 2011. Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-{kappa}B. Proc Natl Acad Sci U S A 108(16):6662-7. [PubMed: 21464294]  [MGI Ref ID J:171373]

Nishikawa M; Chang B; Inoue M. 2004. Inducible NO synthase inhibits the growth of free tumor cells, but enhances the growth of solid tumors. Carcinogenesis 25(11):2101-5. [PubMed: 15205363]  [MGI Ref ID J:93780]

Njoku C; Self SE; Ruiz P; Hofbauer AF; Gilkeson GS; Oates JC. 2008. Inducible nitric oxide synthase inhibitor SD-3651 reduces proteinuria in MRL/lpr mice deficient in the NOS2 gene. J Investig Med 56(7):911-9. [PubMed: 18797415]  [MGI Ref ID J:205256]

Noh HS; Kim DW; Cho GJ; Choi WS; Kang SS. 2006. Increased nitric oxide caused by the ketogenic diet reduces the onset time of kainic acid-induced seizures in ICR mice. Brain Res 1075(1):193-200. [PubMed: 16460714]  [MGI Ref ID J:107300]

Norman MU; Zbytnuik L; Kubes P. 2008. Interferon-gamma limits Th1 lymphocyte adhesion to inflamed endothelium: A nitric oxide regulatory feedback mechanism. Eur J Immunol 38(5):1368-80. [PubMed: 18412158]  [MGI Ref ID J:134151]

Noronha BT; Li JM; Wheatcroft SB; Shah AM; Kearney MT. 2005. Inducible nitric oxide synthase has divergent effects on vascular and metabolic function in obesity. Diabetes 54(4):1082-9. [PubMed: 15793247]  [MGI Ref ID J:105205]

O'Connor RA; Wittmer S; Dalton DK. 2005. Infection-induced apoptosis deletes bystander CD4(+) T cells: a mechanism for suppression of autoimmunity during BCG infection. J Autoimmun 24(2):93-100. [PubMed: 15829401]  [MGI Ref ID J:97542]

Okayama H; Saito M; Oue N; Weiss JM; Stauffer J; Takenoshita S; Wiltrout RH; Hussain SP; Harris CC. 2013. NOS2 enhances KRAS-induced lung carcinogenesis, inflammation and microRNA-21 expression. Int J Cancer 132(1):9-18. [PubMed: 22618808]  [MGI Ref ID J:191775]

Olson N; Greul AK; Hristova M; Bove PF; Kasahara DI; van der Vliet A. 2009. Nitric oxide and airway epithelial barrier function: regulation of tight junction proteins and epithelial permeability. Arch Biochem Biophys 484(2):205-13. [PubMed: 19100237]  [MGI Ref ID J:150975]

Olson N; Kasahara DI; Hristova M; Bernstein R; Janssen-Heininger Y; van der Vliet A. 2011. Modulation of NF-kappaB and hypoxia-inducible factor--1 by S-nitrosoglutathione does not alter allergic airway inflammation in mice. Am J Respir Cell Mol Biol 44(6):813-23. [PubMed: 20693401]  [MGI Ref ID J:185029]

Ono K; Suzuki H; Sawada M. 2010. Delayed neural damage is induced by iNOS-expressing microglia in a brain injury model. Neurosci Lett 473(2):146-50. [PubMed: 20178828]  [MGI Ref ID J:159909]

Parathath SR; Gravanis I; Tsirka SE. 2007. Nitric oxide synthase isoforms undertake unique roles during excitotoxicity. Stroke 38(6):1938-45. [PubMed: 17446423]  [MGI Ref ID J:150557]

Parekh VV; Wu L; Olivares-Villagomez D; Wilson KT; Van Kaer L. 2013. Activated invariant NKT cells control central nervous system autoimmunity in a mechanism that involves myeloid-derived suppressor cells. J Immunol 190(5):1948-60. [PubMed: 23345328]  [MGI Ref ID J:193488]

Parent MA; Wilhelm LB; Kummer LW; Szaba FM; Mullarky IK; Smiley ST. 2006. Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary Yersinia pestis infection. Infect Immun 74(6):3381-6. [PubMed: 16714568]  [MGI Ref ID J:109236]

Park KM; Byun JY; Kramers C; Kim JI; Huang PL; Bonventre JV. 2003. Inducible nitric-oxide synthase is an important contributor to prolonged protective effects of ischemic preconditioning in the mouse kidney. J Biol Chem 278(29):27256-66. [PubMed: 12682064]  [MGI Ref ID J:120673]

Park KM; Kim JI; Ahn Y; Bonventre AJ; Bonventre JV. 2004. Testosterone is responsible for enhanced susceptibility of males to ischemic renal injury. J Biol Chem 279(50):52282-92. [PubMed: 15358759]  [MGI Ref ID J:95182]

Park YH; Shin HJ; Kim SU; Kim JM; Kim JH; Bang DH; Chang KT; Kim BY; Yu DY. 2013. iNOS promotes HBx-induced hepatocellular carcinoma via upregulation of JNK activation. Biochem Biophys Res Commun 435(2):244-9. [PubMed: 23643810]  [MGI Ref ID J:201929]

Pascual O; Ben Achour S; Rostaing P; Triller A; Bessis A. 2012. Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission. Proc Natl Acad Sci U S A 109(4):E197-205. [PubMed: 22167804]  [MGI Ref ID J:180137]

Pearl JE; Torrado E; Tighe M; Fountain JJ; Solache A; Strutt T; Swain S; Appelberg R; Cooper AM. 2012. Nitric oxide inhibits the accumulation of CD4(+) CD44(hi) Tbet(+) CD69(lo) T cells in mycobacterial infection. Eur J Immunol 42(12):3267-79. [PubMed: 22890814]  [MGI Ref ID J:190236]

Peng X; Abdulnour RE; Sammani S; Ma SF; Han EJ; Hasan EJ; Tuder R; Garcia JG; Hassoun PM. 2005. Inducible nitric oxide synthase contributes to ventilator-induced lung injury. Am J Respir Crit Care Med 172(4):470-9. [PubMed: 15937288]  [MGI Ref ID J:114335]

Perreault M; Marette A. 2001. Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med 7(10):1138-43. [PubMed: 11590438]  [MGI Ref ID J:72215]

Peshes-Yaloz N; Rosen D; Sondel PM; Krammer PH; Berke G. 2007. Up-regulation of Fas (CD95) expression in tumour cells in vivo. Immunology 120(4):502-11. [PubMed: 17343612]  [MGI Ref ID J:122702]

Pol O; Sasaki M; Jimenez N; Dawson VL; Dawson TM; Puig MM. 2005. The involvement of nitric oxide in the enhanced expression of mu-opioid receptors during intestinal inflammation in mice. Br J Pharmacol 145(6):758-66. [PubMed: 15852037]  [MGI Ref ID J:114344]

Poljakovic M; Persson K. 2003. Urinary tract infection in iNOS-deficient mice with focus on bacterial sensitivity to nitric oxide. Am J Physiol Renal Physiol 284(1):F22-31. [PubMed: 12494944]  [MGI Ref ID J:127929]

Ponnuswamy P; Ostermeier E; Schrottle A; Chen J; Huang PL; Ertl G; Nieswandt B; Kuhlencordt PJ. 2009. Oxidative stress and compartment of gene expression determine proatherosclerotic effects of inducible nitric oxide synthase. Am J Pathol 174(6):2400-10. [PubMed: 19465644]  [MGI Ref ID J:148912]

Portillo JA; Feliciano LM; Okenka G; Heinzel F; Subauste MC; Subauste CS. 2012. CD40 and tumour necrosis factor-alpha co-operate to up-regulate inducuble nitric oxide synthase expression in macrophages. Immunology 135(2):140-50. [PubMed: 22044243]  [MGI Ref ID J:181390]

Prajeeth CK; Haeberlein S; Sebald H; Schleicher U; Bogdan C. 2011. Leishmania-infected macrophages are targets of NK cell-derived cytokines but not of NK cell cytotoxicity. Infect Immun 79(7):2699-708. [PubMed: 21518784]  [MGI Ref ID J:173486]

Predescu D; Predescu S; Shimizu J; Miyawaki-Shimizu K; Malik AB. 2005. Constitutive eNOS-derived nitric oxide is a determinant of endothelial junctional integrity. Am J Physiol Lung Cell Mol Physiol 289(3):L371-81. [PubMed: 16093363]  [MGI Ref ID J:115733]

Pullamsetti SS; Savai R; Dumitrascu R; Dahal BK; Wilhelm J; Konigshoff M; Zakrzewicz D; Ghofrani HA; Weissmann N; Eickelberg O; Guenther A; Leiper J; Seeger W; Grimminger F; Schermuly RT. 2011. The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis. Sci Transl Med 3(87):87ra53. [PubMed: 21677199]  [MGI Ref ID J:173535]

Qiu H; Kuolee R; Harris G; Chen W. 2009. Role of NADPH phagocyte oxidase in host defense against acute respiratory Acinetobacter baumannii infection in mice. Infect Immun 77(3):1015-21. [PubMed: 19103777]  [MGI Ref ID J:145717]

Raghuvanshi S; Sharma P; Singh S; Van Kaer L; Das G. 2010. Mycobacterium tuberculosis evades host immunity by recruiting mesenchymal stem cells. Proc Natl Acad Sci U S A :. [PubMed: 21135221]  [MGI Ref ID J:167304]

Reece ST; Loddenkemper C; Askew DJ; Zedler U; Schommer-Leitner S; Stein M; Mir FA; Dorhoi A; Mollenkopf HJ; Silverman GA; Kaufmann SH. 2010. Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice. J Clin Invest 120(9):3365-76. [PubMed: 20679732]  [MGI Ref ID J:165286]

Reho JJ; Zheng X; Asico LD; Fisher SA. 2015. Redox signaling and splicing dependent change in myosin phosphatase underlie early versus late changes in NO vasodilator reserve in a mouse LPS model of sepsis. Am J Physiol Heart Circ Physiol 308(9):H1039-50. [PubMed: 25724497]  [MGI Ref ID J:222122]

Ren G; Su J; Zhao X; Zhang L; Zhang J; Roberts AI; Zhang H; Das G; Shi Y. 2008. Apoptotic cells induce immunosuppression through dendritic cells: critical roles of IFN-gamma and nitric oxide. J Immunol 181(5):3277-84. [PubMed: 18713999]  [MGI Ref ID J:138951]

Reynolds CM; Suliman HB; Hollingsworth JW; Welty-Wolf KE; Carraway MS; Piantadosi CA. 2009. Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia. Free Radic Biol Med 46(5):564-72. [PubMed: 19073249]  [MGI Ref ID J:145176]

Ridnour LA; Dhanapal S; Hoos M; Wilson J; Lee J; Cheng RY; Brueggemann EE; Hines HB; Wilcock DM; Vitek MP; Wink DA; Colton CA. 2012. Nitric oxide-mediated regulation of beta-amyloid clearance via alterations of MMP-9/TIMP-1. J Neurochem 123(5):736-49. [PubMed: 23016931]  [MGI Ref ID J:190735]

Rigamonti E; Touvier T; Clementi E; Manfredi AA; Brunelli S; Rovere-Querini P. 2013. Requirement of inducible nitric oxide synthase for skeletal muscle regeneration after acute damage. J Immunol 190(4):1767-77. [PubMed: 23335752]  [MGI Ref ID J:193495]

Rivera J; Mukherjee J; Weiss LM; Casadevall A. 2002. Antibody Efficacy in Murine Pulmonary Cryptococcus neoformans Infection: A Role for Nitric Oxide. J Immunol 168(7):3419-27. [PubMed: 11907100]  [MGI Ref ID J:75578]

Rocha FJ; Schleicher U; Mattner J; Alber G; Bogdan C. 2007. Cytokines, signaling pathways, and effector molecules required for the control of Leishmania (Viannia) braziliensis in mice. Infect Immun 75(8):3823-32. [PubMed: 17517868]  [MGI Ref ID J:123377]

Ropelle ER; Pauli JR; Cintra DE; da Silva AS; De Souza CT; Guadagnini D; Carvalho BM; Caricilli AM; Katashima CK; Carvalho-Filho MA; Hirabara S; Curi R; Velloso LA; Saad MJ; Carvalheira JB. 2013. Targeted disruption of inducible nitric oxide synthase protects against aging, S-nitrosation, and insulin resistance in muscle of male mice. Diabetes 62(2):466-70. [PubMed: 22991447]  [MGI Ref ID J:208474]

Rosypal AC; Lindsay DS; Duncan R Jr; Ahmed SA; Zajac AM; Dubey JP. 2002. Mice lacking the gene for inducible or endothelial nitric oxide are resistant to sporocyst induced Sarcocystis neurona infections. Vet Parasitol 103(4):315-21. [PubMed: 11777610]  [MGI Ref ID J:106322]

Rothfuchs AG; Gigliotti D; Palmblad K; Andersson U; Wigzell H; Rottenberg ME. 2001. IFN-alphabeta-dependent, IFN-gamma secretion by bone marrow-derived macrophages controls an intracellular bacterial infection. J Immunol 167(11):6453-61. [PubMed: 11714812]  [MGI Ref ID J:72825]

Rottenberg ME; Gigliotti Rothfuchs AC; Gigliotti D; Svanholm C; Bandholtz L; Wigzell H. 1999. Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice. J Immunol 162(5):2829-36. [PubMed: 10072530]  [MGI Ref ID J:124536]

Rudkowski JC; Barreiro E; Harfouche R; Goldberg P; Kishta O; D'Orleans-Juste P; Labonte J; Lesur O; Hussain SN. 2004. Roles of iNOS and nNOS in sepsis-induced pulmonary apoptosis. Am J Physiol Lung Cell Mol Physiol 286(4):L793-800. [PubMed: 14660484]  [MGI Ref ID J:108149]

Russell MS; Dudani R; Krishnan L; Sad S. 2009. IFN-gamma expressed by T cells regulates the persistence of antigen presentation by limiting the survival of dendritic cells. J Immunol 183(12):7710-8. [PubMed: 19923462]  [MGI Ref ID J:157498]

Saini AS; Shenoy GN; Rath S; Bal V; George A. 2014. Inducible nitric oxide synthase is a major intermediate in signaling pathways for the survival of plasma cells. Nat Immunol 15(3):275-82. [PubMed: 24441790]  [MGI Ref ID J:209367]

Sam F; Sawyer DB; Xie Z; Chang DL; Ngoy S; Brenner DA; Siwik DA; Singh K; Apstein CS; Colucci WS. 2001. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. Circ Res 89(4):351-6. [PubMed: 11509452]  [MGI Ref ID J:115413]

Saraswathy S; Nguyen AM; Rao NA. 2010. The role of TLR4 in photoreceptor {alpha}a crystallin upregulation during early experimental autoimmune uveitis. Invest Ophthalmol Vis Sci 51(7):3680-6. [PubMed: 20207969]  [MGI Ref ID J:164096]

Sato K; Ozaki K; Oh I; Meguro A; Hatanaka K; Nagai T; Muroi K; Ozawa K. 2007. Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood 109(1):228-34. [PubMed: 16985180]  [MGI Ref ID J:142176]

Scallan JP; Davis MJ. 2013. Genetic removal of basal nitric oxide enhances contractile activity in isolated murine collecting lymphatic vessels. J Physiol 591(Pt 8):2139-56. [PubMed: 23420659]  [MGI Ref ID J:208101]

Scanga CA; Mohan VP; Tanaka K; Alland D; Flynn JL; Chan J. 2001. The Inducible Nitric Oxide Synthase Locus Confers Protection against Aerogenic Challenge of Both Clinical and Laboratory Strains of Mycobacterium tuberculosis in Mice. Infect Immun 69(12):7711-7. [PubMed: 11705952]  [MGI Ref ID J:73135]

Scott DJ; Hull MA; Cartwright EJ; Lam WK; Tisbury A; Poulsom R; Markham AF; Bonifer C; Coletta PL. 2001. Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the apc(min/+) mouse. Gastroenterology 121(4):889-99. [PubMed: 11606502]  [MGI Ref ID J:72030]

Seimetz M; Parajuli N; Pichl A; Veit F; Kwapiszewska G; Weisel FC; Milger K; Egemnazarov B; Turowska A; Fuchs B; Nikam S; Roth M; Sydykov A; Medebach T; Klepetko W; Jaksch P; Dumitrascu R; Garn H; Voswinckel R; Kostin S; Seeger W; Schermuly RT; Grimminger F; Ghofrani HA; Weissmann N. 2011. Inducible NOS Inhibition Reverses Tobacco-Smoke-Induced Emphysema and Pulmonary Hypertension in Mice. Cell 147(2):293-305. [PubMed: 22000010]  [MGI Ref ID J:177505]

Sercan O; Hammerling GJ; Arnold B; Schuler T. 2006. Innate immune cells contribute to the IFN-gamma-dependent regulation of antigen-specific CD8+ T cell homeostasis. J Immunol 176(2):735-9. [PubMed: 16393956]  [MGI Ref ID J:126599]

Seril DN; Liao J; Yang GY. 2007. Colorectal carcinoma development in inducible nitric oxide synthase-deficient mice with dextran sulfate sodium-induced ulcerative colitis. Mol Carcinog 46(5):341-53. [PubMed: 17219424]  [MGI Ref ID J:121634]

Shesely EG; Gilbert C; Granderson G; Carretero CD; Carretero OA; Beierwaltes WH. 2001. Nitric oxide synthase gene knockout mice do not become hypertensive during pregnancy. Am J Obstet Gynecol 185(5):1198-203. [PubMed: 11717657]  [MGI Ref ID J:117212]

Shesely EG; Maeda N; Kim HS; Desai KM; Krege JH; Laubach VE; Sherman PA; Sessa WC; Smithies O. 1996. Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci U S A 93(23):13176-81. [PubMed: 8917564]  [MGI Ref ID J:36559]

Shie FS; Montine KS; Breyer RM; Montine TJ. 2005. Microglial EP2 is critical to neurotoxicity from activated cerebral innate immunity. Glia 52(1):70-7. [PubMed: 15920732]  [MGI Ref ID J:156154]

Shimazu T; Otani H; Yoshioka K; Fujita M; Okazaki T; Iwasaka T. 2011. Sepiapterin enhances angiogenesis and functional recovery in mice after myocardial infarction. Am J Physiol Heart Circ Physiol 301(5):H2061-72. [PubMed: 21890687]  [MGI Ref ID J:178332]

Shin HJ; Park YH; Kim SU; Moon HB; Park do S; Han YH; Lee CH; Lee DS; Song IS; Lee DH; Kim M; Kim NS; Kim DG; Kim JM; Kim SK; Kim YN; Kim SS; Choi CS; Kim YB; Yu DY. 2011. Hepatitis B virus X protein regulates hepatic glucose homeostasis via activation of inducible nitric oxide synthase. J Biol Chem 286(34):29872-81. [PubMed: 21690090]  [MGI Ref ID J:176632]

Simmons CP; Goncalves NS; Ghaem-Maghami M; Bajaj-Elliott M; Clare S; Neves B; Frankel G; Dougan G; MacDonald TT. 2002. Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma. J Immunol 168(4):1804-12. [PubMed: 11823513]  [MGI Ref ID J:74480]

Somers JR; Beck PL; Lees-Miller JP; Roach D; Li Y; Guo J; Loken S; Zhan S; Semeniuk L; Duff HJ. 2008. iNOS in cardiac myocytes plays a critical role in death in a murine model of hypertrophy induced by calcineurin. Am J Physiol Heart Circ Physiol 295(3):H1122-H1131. [PubMed: 18621856]  [MGI Ref ID J:141285]

Speyer CL; Neff TA; Warner RL; Guo RF; Sarma JV; Riedemann NC; Murphy ME; Murphy HS; Ward PA. 2003. Regulatory effects of iNOS on acute lung inflammatory responses in mice. Am J Pathol 163(6):2319-28. [PubMed: 14633605]  [MGI Ref ID J:86598]

Spohr F; Cornelissen AJ; Busch C; Gebhard MM; Motsch J; Martin EO; Weimann J. 2005. Role of endogenous nitric oxide in endotoxin-induced alteration of hypoxic pulmonary vasoconstriction in mice. Am J Physiol Heart Circ Physiol 289(2):H823-31. [PubMed: 15778287]  [MGI Ref ID J:100323]

Stadler K; Bonini MG; Dallas S; Duma D; Mason RP; Kadiiska MB. 2008. Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis. Am J Physiol Endocrinol Metab 295(2):E456-62. [PubMed: 18559982]  [MGI Ref ID J:139996]

Steed MM; Tyagi N; Sen U; Schuschke DA; Joshua IG; Tyagi SC. 2010. Functional consequences of the collagen/elastin switch in vascular remodeling in hyperhomocysteinemic wild-type, eNOS-/-, and iNOS-/- mice. Am J Physiol Lung Cell Mol Physiol 299(3):L301-11. [PubMed: 20581102]  [MGI Ref ID J:164613]

Streifel KM; Moreno JA; Hanneman WH; Legare ME; Tjalkens RB. 2012. Gene deletion of nos2 protects against manganese-induced neurological dysfunction in juvenile mice. Toxicol Sci 126(1):183-92. [PubMed: 22174044]  [MGI Ref ID J:183641]

Strobl B; Bubic I; Bruns U; Steinborn R; Lajko R; Kolbe T; Karaghiosoff M; Kalinke U; Jonjic S; Muller M. 2005. Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus. J Immunol 175(6):4000-8. [PubMed: 16148148]  [MGI Ref ID J:116703]

Sugimura Y; Murase T; Oyama K; Uchida A; Sato N; Hayasaka S; Kano Y; Takagishi Y; Hayashi Y; Oiso Y; Murata Y. 2009. Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes. Diabetologia 52(5):962-71. [PubMed: 19283362]  [MGI Ref ID J:148113]

Sugita H; Fujimoto M; Yasukawa T; Shimizu N; Sugita M; Yasuhara S; Martyn JA; Kaneki M. 2005. Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells. J Biol Chem 280(14):14203-11. [PubMed: 15805118]  [MGI Ref ID J:98746]

Suliman HB; Babiker A; Withers CM; Sweeney TE; Carraway MS; Tatro LG; Bartz RR; Welty-Wolf KE; Piantadosi CA. 2010. Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice. Free Radic Biol Med 48(5):736-46. [PubMed: 20043987]  [MGI Ref ID J:157083]

Sun K; Gan Y; Metzger DW. 2011. Analysis of murine genetic predisposition to pneumococcal infection reveals a critical role of alveolar macrophages in maintaining the sterility of the lower respiratory tract. Infect Immun 79(5):1842-7. [PubMed: 21321074]  [MGI Ref ID J:171962]

Sunil VR; Shen J; Patel-Vayas K; Gow AJ; Laskin JD; Laskin DL. 2012. Role of reactive nitrogen species generated via inducible nitric oxide synthase in vesicant-induced lung injury, inflammation and altered lung functioning. Toxicol Appl Pharmacol 261(1):22-30. [PubMed: 22446026]  [MGI Ref ID J:186088]

Suvorava T; Stegbauer J; Thieme M; Pick S; Friedrich S; Rump LC; Hohlfeld T; Kojda G. 2015. Sustained hypertension despite endothelial-specific eNOS rescue in eNOS-deficient mice. Biochem Biophys Res Commun 458(3):576-83. [PubMed: 25680465]  [MGI Ref ID J:220487]

Tangpong J; Sompol P; Vore M; St Clair W; Butterfield DA; St Clair DK. 2008. Tumor necrosis factor alpha-mediated nitric oxide production enhances manganese superoxide dismutase nitration and mitochondrial dysfunction in primary neurons: an insight into the role of glial cells. Neuroscience 151(2):622-9. [PubMed: 18160224]  [MGI Ref ID J:130957]

Tanioka T; Tamura Y; Fukaya M; Shinozaki S; Mao J; Kim M; Shimizu N; Kitamura T; Kaneki M. 2011. Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta. J Biol Chem 286(33):29388-96. [PubMed: 21700708]  [MGI Ref ID J:175918]

Tao F; Tao YX; Mao P; Zhao C; Li D; Liaw WJ; Raja SN; Johns RA. 2003. Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase. Neuroscience 120(3):847-54. [PubMed: 12895524]  [MGI Ref ID J:126175]

Tarin C; Lavin B; Gomez M; Saura M; Diez-Juan A; Zaragoza C. 2011. The extracellular matrix metalloproteinase inducer EMMPRIN is a target of nitric oxide in myocardial ischemia/reperfusion. Free Radic Biol Med 51(2):387-95. [PubMed: 21570464]  [MGI Ref ID J:174100]

Tatemichi M; Ogura T; Sakurazawa N; Nagata H; Sugita M; Esumi H. 2003. Roles of inducible nitric oxide synthase in the development and healing of experimentally induced gastric ulcers. Int J Exp Pathol 84(5):213-20. [PubMed: 14690480]  [MGI Ref ID J:87317]

Tavener SA; Kubes P. 2006. Cellular and molecular mechanisms underlying LPS-associated myocyte impairment. Am J Physiol Heart Circ Physiol 290(2):H800-6. [PubMed: 16172157]  [MGI Ref ID J:106721]

TeKippe M; Harrison DE; Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp Hematol 31(6):521-7. [PubMed: 12829028]  [MGI Ref ID J:115677]

Theodorakis NG; Wang YN; Skill NJ; Metz MA; Cahill PA; Redmond EM; Sitzmann JV. 2003. The role of nitric oxide synthase isoforms in extrahepatic portal hypertension: studies in gene-knockout mice. Gastroenterology 124(5):1500-8. [PubMed: 12730888]  [MGI Ref ID J:107756]

Thoeni G; Stoitzner P; Brandacher G; Romani N; Heufler C; Werner-Felmayer G; Werner ER. 2005. Tetrahydro-4-aminobiopterin attenuates dendritic cell-induced T cell priming independently from inducible nitric oxide synthase. J Immunol 174(12):7584-91. [PubMed: 15944258]  [MGI Ref ID J:100788]

Tranguch S; Huet-Hudson Y. 2003. Decreased viability of nitric oxide synthase double knockout mice. Mol Reprod Dev 65(2):175-9. [PubMed: 12704728]  [MGI Ref ID J:83112]

Tsui AK; Marsden PA; Mazer CD; Adamson SL; Henkelman RM; Ho JJ; Wilson DF; Heximer SP; Connelly KA; Bolz SS; Lidington D; El-Beheiry MH; Dattani ND; Chen KM; Hare GM. 2011. Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia. Proc Natl Acad Sci U S A 108(42):17544-9. [PubMed: 21976486]  [MGI Ref ID J:177441]

Uemura T; Stringer DE; Blohm-Mangone KA; Gerner EW. 2010. Polyamine transport is mediated by both endocytic and solute carrier transport mechanisms in the gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol 299(2):G517-22. [PubMed: 20522643]  [MGI Ref ID J:163345]

Ullrich R; Bloch KD; Ichinose F; Steudel W; Zapol WM. 1999. Hypoxic pulmonary blood flow redistribution and arterial oxygenation in endotoxin-challenged NOS2-deficient mice. J Clin Invest 104(10):1421-9. [PubMed: 10562304]  [MGI Ref ID J:58501]

Uppington H; Menager N; Boross P; Wood J; Sheppard M; Verbeek S; Mastroeni P. 2006. Effect of immune serum and role of individual Fcgamma receptors on the intracellular distribution and survival of Salmonella enterica serovar Typhimurium in murine macrophages. Immunology 119(2):147-58. [PubMed: 16836651]  [MGI Ref ID J:118526]

Vareniuk I; Pavlov IA; Obrosova IG. 2008. Inducible nitric oxide synthase gene deficiency counteracts multiple manifestations of peripheral neuropathy in a streptozotocin-induced mouse model of diabetes. Diabetologia 51(11):2126-33. [PubMed: 18802679]  [MGI Ref ID J:142727]

Velez CD; Lewis CJ; Kasper DL; Cobb BA. 2009. Type I Streptococcus pneumoniae carbohydrate utilizes a nitric oxide and MHC II-dependent pathway for antigen presentation. Immunology 127(1):73-82. [PubMed: 18778282]  [MGI Ref ID J:155663]

Vig M; Srivastava S; Kandpal U; Sade H; Lewis V; Sarin A; George A; Bal V; Durdik JM; Rath S. 2004. Inducible nitric oxide synthase in T cells regulates T cell death and immune memory. J Clin Invest 113(12):1734-42. [PubMed: 15199408]  [MGI Ref ID J:90903]

Villalta SA; Nguyen HX; Deng B; Gotoh T; Tidball JG. 2009. Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy. Hum Mol Genet 18(3):482-96. [PubMed: 18996917]  [MGI Ref ID J:143545]

Vishwakarma V; Pati NB; Chandel HS; Sahoo SS; Saha B; Suar M. 2012. Evaluation of Salmonella enterica serovar Typhimurium TTSS-2 deficient fur mutant as safe live-attenuated vaccine candidate for immunocompromised mice. PLoS One 7(12):e52043. [PubMed: 23284865]  [MGI Ref ID J:195626]

Vissers YL; Hallemeesch MM; Soeters PB; Lamers WH; Deutz NE. 2004. NOS2 deficiency increases intestinal metabolism both in nonstimulated and endotoxemic mice. Am J Physiol Gastrointest Liver Physiol 286(5):G747-51. [PubMed: 14656712]  [MGI Ref ID J:95679]

Wang L; Mehta S; Gillis C; Law C; Taneja R. 2010. Modulation of neutrophil apoptosis by murine pulmonary microvascular endothelial cell inducible nitric oxide synthase. Biochem Biophys Res Commun 401(2):207-12. [PubMed: 20833133]  [MGI Ref ID J:165852]

Wang LF; Mehta S; Weicker S; Scott JA; Joseph M; Razavi HM; McCormack DG. 2001. Relative contribution of hemopoietic and pulmonary parenchymal cells to lung inducible nitric oxide synthase (inos) activity in murine endotoxemia. Biochem Biophys Res Commun 283(3):694-9. [PubMed: 11341781]  [MGI Ref ID J:114281]

Wang T. 2002. Role of iNOS and eNOS in modulating proximal tubule transport and acid-base balance. Am J Physiol Renal Physiol 283(4):F658-62. [PubMed: 12217856]  [MGI Ref ID J:113614]

Wang T; Inglis FM; Kalb RG. 2000. Defective fluid and HCO(3)(-) absorption in proximal tubule of neuronal nitric oxide synthase-knockout mice. Am J Physiol Renal Physiol 279(3):F518-24. [PubMed: 10966931]  [MGI Ref ID J:64896]

Watanuki M; Sakai A; Sakata T; Tsurukami H; Miwa M; Uchida Y; Watanabe K; Ikeda K; Nakamura T. 2002. Role of inducible nitric oxide synthase in skeletal adaptation to acute increases in mechanical loading. J Bone Miner Res 17(6):1015-25. [PubMed: 12054156]  [MGI Ref ID J:112399]

Weberpals M; Hermes M; Hermann S; Kummer MP; Terwel D; Semmler A; Berger M; Schafers M; Heneka MT. 2009. NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits. J Neurosci 29(45):14177-84. [PubMed: 19906966]  [MGI Ref ID J:154742]

Wei W; Li B; Hanes MA; Kakar S; Chen X; Liu L. 2010. S-nitrosylation from GSNOR deficiency impairs DNA repair and promotes hepatocarcinogenesis. Sci Transl Med 2(19):19ra13. [PubMed: 20371487]  [MGI Ref ID J:167883]

Wei W; Yang Z; Tang CH; Liu L. 2011. Targeted deletion of GSNOR in hepatocytes of mice causes nitrosative inactivation of O6-alkylguanine-DNA alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine. Carcinogenesis 32(7):973-7. [PubMed: 21385828]  [MGI Ref ID J:173666]

White JK; Mastroeni P; Popoff JF; Evans CA; Blackwell JM. 2005. Slc11a1-mediated resistance to Salmonella enterica serovar Typhimurium and Leishmania donovani infections does not require functional inducible nitric oxide synthase or phagocyte oxidase activity. J Leukoc Biol 77(3):311-20. [PubMed: 15601666]  [MGI Ref ID J:97453]

Whiteus C; Freitas C; Grutzendler J. 2014. Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period. Nature 505(7483):407-11. [PubMed: 24305053]  [MGI Ref ID J:207919]

Wiese M; Gerlach RG; Popp I; Matuszak J; Mahapatro M; Castiglione K; Chakravortty D; Willam C; Hensel M; Bogdan C; Jantsch J. 2012. Hypoxia-mediated impairment of the mitochondrial respiratory chain inhibits the bactericidal activity of macrophages. Infect Immun 80(4):1455-66. [PubMed: 22252868]  [MGI Ref ID J:182549]

Wilcock DM; Gharkholonarehe N; Van Nostrand WE; Davis J; Vitek MP; Colton CA. 2009. Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. J Neurosci 29(25):7957-65. [PubMed: 19553436]  [MGI Ref ID J:150418]

Wilcock DM; Lewis MR; Van Nostrand WE; Davis J; Previti ML; Gharkholonarehe N; Vitek MP; Colton CA. 2008. Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci 28(7):1537-45. [PubMed: 18272675]  [MGI Ref ID J:132221]

Wilcock DM; Vitek MP; Colton CA. 2009. Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease. Neuroscience 159(3):1055-69. [PubMed: 19356689]  [MGI Ref ID J:148938]

Winter SE; Winter MG; Xavier MN; Thiennimitr P; Poon V; Keestra AM; Laughlin RC; Gomez G; Wu J; Lawhon SD; Popova IE; Parikh SJ; Adams LG; Tsolis RM; Stewart VJ; Baumler AJ. 2013. Host-derived nitrate boosts growth of E. coli in the inflamed gut. Science 339(6120):708-11. [PubMed: 23393266]  [MGI Ref ID J:193601]

Wipke BT; Allen PM. 2001. Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis. J Immunol 167(3):1601-8. [PubMed: 11466382]  [MGI Ref ID J:120467]

Wood KC; Hebbel RP; Lefer DJ; Granger DN. 2006. Critical role of endothelial cell-derived nitric oxide synthase in sickle cell disease-induced microvascular dysfunction. Free Radic Biol Med 40(8):1443-53. [PubMed: 16631534]  [MGI Ref ID J:108238]

Wu D; Xu C; Cederbaum A. 2009. Role of nitric oxide and nuclear factor-kappaB in the CYP2E1 potentiation of tumor necrosis factor alpha hepatotoxicity in mice. Free Radic Biol Med 46(4):480-91. [PubMed: 19063961]  [MGI Ref ID J:145179]

Wuthrich M; Filutowicz HI; Warner T; Klein BS. 2002. Requisite elements in vaccine immunity to Blastomyces dermatitidis: plasticity uncovers vaccine potential in immune-deficient hosts. J Immunol 169(12):6969-76. [PubMed: 12471131]  [MGI Ref ID J:118419]

Xi L; Jarrett NC; Hess ML; Kukreja RC. 1999. Essential role of inducible nitric oxide synthase in monophosphoryl lipid A-induced late cardioprotection: evidence from pharmacological inhibition and gene knockout mice. Circulation 99(16):2157-63. [PubMed: 10217657]  [MGI Ref ID J:54841]

Xi L; Jarrett NC; Hess ML; Kukreja RC. 1999. Myocardial ischemia/reperfusion injury in the inducible nitric oxide synthase knockout mice. Life Sci 65(9):935-45. [PubMed: 10465353]  [MGI Ref ID J:57432]

Xu G; Zhang Y; Zhang L; Ren G; Shi Y. 2008. Bone marrow stromal cells induce apoptosis of lymphoma cells in the presence of IFNgamma and TNF by producing nitric oxide. Biochem Biophys Res Commun 375(4):666-70. [PubMed: 18755151]  [MGI Ref ID J:140996]

Xu W; Xin L; Soong L; Zhang K. 2011. Sphingolipid degradation by Leishmania major is required for its resistance to acidic pH in the mammalian host. Infect Immun 79(8):3377-87. [PubMed: 21576322]  [MGI Ref ID J:175272]

Yan BS; Pichugin AV; Jobe O; Helming L; Eruslanov EB; Gutierrez-Pabello JA; Rojas M; Shebzukhov YV; Kobzik L; Kramnik I. 2007. Progression of pulmonary tuberculosis and efficiency of bacillus Calmette-Guerin vaccination are genetically controlled via a common sst1-mediated mechanism of innate immunity. J Immunol 179(10):6919-32. [PubMed: 17982083]  [MGI Ref ID J:154010]

Yang JZ; Ajonuma LC; Rowlands DK; Tsang LL; Ho LS; Lam SY; Chen WY; Zhou CX; Chung YW; Cho CY; Tse JY; James AE; Chan HC. 2005. The role of inducible nitric oxide synthase in gamete interaction and fertilization: a comparative study on knockout mice of three NOS isoforms. Cell Biol Int 29(9):785-91. [PubMed: 16087361]  [MGI Ref ID J:112824]

Yang S; Porter VA; Cornfield DN; Milla C; Panoskaltsis-Mortari A; Blazar BR; Haddad IY. 2001. Effects of oxidant stress on inflammation and survival of iNOS knockout mice after marrow transplantation. Am J Physiol Lung Cell Mol Physiol 281(4):L922-30. [PubMed: 11557596]  [MGI Ref ID J:72096]

Yang Z; Huang YC; Koziel H; de Crom R; Ruetten H; Wohlfart P; Thomsen RW; Kahlert JA; Sorensen HT; Jozefowski S; Colby A; Kobzik L. 2014. Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target. Elife 3:. [PubMed: 25317947]  [MGI Ref ID J:218028]

Yang Z; Wang ZE; Doulias PT; Wei W; Ischiropoulos H; Locksley RM; Liu L. 2010. Lymphocyte Development Requires S-nitrosoglutathione Reductase. J Immunol 185(11):6664-9. [PubMed: 20980633]  [MGI Ref ID J:166150]

Yerushalmi HF; Besselsen DG; Ignatenko NA; Blohm-Mangone KA; Padilla-Torres JL; Stringer DE; Cui H; Holubec H; Payne CM; Gerner EW. 2006. The role of NO synthases in arginine-dependent small intestinal and colonic carcinogenesis. Mol Carcinog 45(2):93-105. [PubMed: 16329147]  [MGI Ref ID J:107079]

Yook YH; Kang KH; Maeng O; Kim TR; Lee JO; Kang KI; Kim YS; Paik SG; Lee H. 2004. Nitric oxide induces BNIP3 expression that causes cell death in macrophages. Biochem Biophys Res Commun 321(2):298-305. [PubMed: 15358175]  [MGI Ref ID J:91305]

Zaki MH; Fujii S; Okamoto T; Islam S; Khan S; Ahmed KA; Sawa T; Akaike T. 2009. Cytoprotective function of heme oxygenase 1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis. J Immunol 182(6):3746-56. [PubMed: 19265153]  [MGI Ref ID J:145919]

Zaragoza C; Lopez-Rivera E; Garcia-Rama C; Saura M; Martinez-Ruiz A; Lizarbe TR; Martin-de-Lara F; Lamas S. 2006. Cbfa-1 mediates nitric oxide regulation of MMP-13 in osteoblasts. J Cell Sci 119(Pt 9):1896-902. [PubMed: 16636074]  [MGI Ref ID J:108930]

Zaragoza C; Ocampo CJ; Saura M; Bao C; Leppo M; Lafond-Walker A; Thiemann DR; Hruban R; Lowenstein CJ. 1999. Inducible nitric oxide synthase protection against coxsackievirus pancreatitis. J Immunol 163(10):5497-504. [PubMed: 10553076]  [MGI Ref ID J:58451]

Zeidler PC; Millecchia LM; Castranova V. 2004. Role of inducible nitric oxide synthase-derived nitric oxide in lipopolysaccharide plus interferon-gamma-induced pulmonary inflammation. Toxicol Appl Pharmacol 195(1):45-54. [PubMed: 14962504]  [MGI Ref ID J:87978]

Zelickson BR; Benavides GA; Johnson MS; Chacko BK; Venkatraman A; Landar A; Betancourt AM; Bailey SM; Darley-Usmar VM. 2011. Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes. Biochim Biophys Acta 1807(12):1573-82. [PubMed: 21971515]  [MGI Ref ID J:180333]

Zell JA; Ignatenko NA; Yerushalmi HF; Ziogas A; Besselsen DG; Gerner EW; Anton-Culver H. 2007. Risk and risk reduction involving arginine intake and meat consumption in colorectal tumorigenesis and survival. Int J Cancer 120(3):459-68. [PubMed: 17096347]  [MGI Ref ID J:117825]

Zhang P; Xu X; Hu X; van Deel ED; Zhu G; Chen Y. 2007. Inducible nitric oxide synthase deficiency protects the heart from systolic overload-induced ventricular hypertrophy and congestive heart failure. Circ Res 100(7):1089-98. [PubMed: 17363700]  [MGI Ref ID J:133913]

Zhao T; Xi L; Chelliah J; Levasseur JE; Kukreja RC. 2000. Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A(1) receptors: evidence from gene-knockout mice. Circulation 102(8):902-7. [PubMed: 10952960]  [MGI Ref ID J:103302]

Zhao TC; Zhang L; Liu JT; Guo TL. 2012. Disruption of Nox2 and TNFRp55/p75 eliminates cardioprotection induced by anisomycin. Am J Physiol Heart Circ Physiol 303(10):H1263-72. [PubMed: 22982779]  [MGI Ref ID J:191277]

Zhao Y; Ferguson DJ; Wilson DC; Howard JC; Sibley LD; Yap GS. 2009. Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophages. J Immunol 182(6):3775-81. [PubMed: 19265156]  [MGI Ref ID J:145916]

Zhou J; Dehne N; Brune B. 2009. Nitric oxide causes macrophage migration via the HIF-1-stimulated small GTPases Cdc42 and Rac1. Free Radic Biol Med 47(6):741-9. [PubMed: 19523512]  [MGI Ref ID J:152571]

Zhou J; Tang PC; Qin L; Gayed PM; Li W; Skokos EA; Kyriakides TR; Pober JS; Tellides G. 2010. CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses. J Exp Med 207(9):1951-66. [PubMed: 20733031]  [MGI Ref ID J:165720]

Zhu B; Bando Y; Xiao S; Yang K; Anderson AC; Kuchroo VK; Khoury SJ. 2007. CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis. J Immunol 179(8):5228-37. [PubMed: 17911608]  [MGI Ref ID J:153031]

Zhu B; Kennedy JK; Wang Y; Sandoval-Garcia C; Cao L; Xiao S; Wu C; Elyaman W; Khoury SJ. 2011. Plasticity of Ly-6C(hi) myeloid cells in T cell regulation. J Immunol 187(5):2418-32. [PubMed: 21824867]  [MGI Ref ID J:179261]

Zhu DY; Liu SH; Sun HS; Lu YM. 2003. Expression of inducible nitric oxide synthase after focal cerebral ischemia stimulates neurogenesis in the adult rodent dentate gyrus. J Neurosci 23(1):223-9. [PubMed: 12514219]  [MGI Ref ID J:124823]

Zhu X; Zhao H; Graveline AR; Buys ES; Schmidt U; Bloch KD; Rosenzweig A; Chao W. 2006. MyD88 and NOS2 are essential for toll-like receptor 4-mediated survival effect in cardiomyocytes. Am J Physiol Heart Circ Physiol 291(4):H1900-9. [PubMed: 16648192]  [MGI Ref ID J:116319]

Zingarelli B; Szabo C; Salzman AL. 1999. Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase. Gut 45(2):199-209. [PubMed: 10403731]  [MGI Ref ID J:56980]

Zoller EE; Lykens JE; Terrell CE; Aliberti J; Filipovich AH; Henson PM; Jordan MB. 2011. Hemophagocytosis causes a consumptive anemia of inflammation. J Exp Med 208(6):1203-14. [PubMed: 21624938]  [MGI Ref ID J:176823]

de Jonge WJ; Hallemeesch MM; Kwikkers KL; Ruijter JM; de Gier-de Vries C; van Roon MA; Meijer AJ; Marescau B; de Deyn PP; Deutz NE; Lamers WH. 2002. Overexpression of arginase I in enterocytes of transgenic mice elicits a selective arginine deficiency and affects skin, muscle, and lymphoid development. Am J Clin Nutr 76(1):128-40. [PubMed: 12081826]  [MGI Ref ID J:80556]

de Jonge WJ; Kwikkers KL; te Velde AA; van Deventer SJ; Nolte MA; Mebius RE; Ruijter JM; Lamers MC; Lamers WH. 2002. Arginine deficiency affects early B cell maturation and lymphoid organ development in transgenic mice. J Clin Invest 110(10):1539-48. [PubMed: 12438451]  [MGI Ref ID J:80204]

van Der Heyde HC; Gu Y; Zhang Q; Sun G; Grisham MB. 2000. Nitric oxide is neither necessary nor sufficient for resolution of plasmodium chabaudi malaria in mice J Immunol 165(6):3317-23. [PubMed: 10975849]  [MGI Ref ID J:64564]

van Rossum AM; Lysenko ES; Weiser JN. 2005. Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun 73(11):7718-26. [PubMed: 16239576]  [MGI Ref ID J:104292]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice may be bred as homozygotes. Colony managers at The Jackson Laboratory report these mice have a tendency to aggressively barber one another (specifically the whiskers). Attempts to breed away from this characteristic have not been successful to date (June 2009).
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $320.00Female or MaleHomozygous for Nos2tm1Lau  
Price per Pair (US dollars $)Pair Genotype
$640.00Homozygous for Nos2tm1Lau x Homozygous for Nos2tm1Lau  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $416.00Female or MaleHomozygous for Nos2tm1Lau  
Price per Pair (US dollars $)Pair Genotype
$832.00Homozygous for Nos2tm1Lau x Homozygous for Nos2tm1Lau  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

   100903 B6129PF2/J (approximate)
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Important Note

Of note, colony managers at The Jackson Laboratory report these mice have a tendency to aggressively barber one another (specifically the whiskers). Attempts to breed away from this characteristic have not been successful to date (June 2009).

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries regarding Terms of Use

Contracts Administration


JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.