Strain Name:

B6.129S7-Hbatm1Paz/J

Stock Number:

002616

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6.129S7-Hba-a1tm1Paz Hba-a2tm1Paz/J    (Changed: 07-AUG-08 )
Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C57BL/6
Donor Strain 129S7 via AB1 ES cell line (+Hprt-bm2)
 
Donating InvestigatorDr. Chris Paszty,   Amgen, Inc.

Appearance
black
Related Genotype: a/a

Description
Mice homozygous for this mutation die in utero. The apparent cause of death is severe anemia as no alpha-globin polypeptide is found in these animals.

Control Information

  Control
   Wild-type from the colony
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Hbatm1Paz allele
003342   STOCK Hbatm1Paz Hbbtm1Tow Tg(HBA-HBBs)41Paz/J
View Strains carrying   Hbatm1Paz     (1 strain)

Strains carrying other alleles of Hba
001622   B6.Cg-Gpi1a Hbath-J
001175   B6.Cg-Hbap/J
000745   B6.SEC-Hbab/J
000191   B6.SM-Hbad/J
013071   B6;129-Hbatm1(HBA)Tow Hbbtm2(HBG1,HBB*)Tow/Hbbtm3(HBG1,HBB)Tow/J
000802   WB.Cg-Hbath-J/J
View Strains carrying other alleles of Hba     (6 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Characteristics of this human disease are associated with transgenes and other mutation types in the mouse.
Hemoglobin--Alpha Locus 1; HBA1
Hydrops Fetalis, Nonimmune; NIHF
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Hbatm1Paz/Hba+

        involves: 129S7/SvEvBrd
  • hematopoietic system phenotype
  • decreased hemoglobin content   (MGI Ref ID J:117887)
  • decreased mean corpuscular hemoglobin   (MGI Ref ID J:117887)
  • decreased mean corpuscular volume   (MGI Ref ID J:117887)
  • reticulocytosis   (MGI Ref ID J:117887)

Hbatm1Paz/Hbatm1Paz

        involves: 129S7/SvEvBrd
  • mortality/aging
  • complete lethality throughout fetal growth and development
    • death between E14.5 and E16.5: all homozygotes are dead by E16.5   (MGI Ref ID J:28392)
  • growth/size/body phenotype
  • decreased fetal size
    • noticeably smaller than littermates at E14.5   (MGI Ref ID J:28392)
  • hematopoietic system phenotype
  • abnormal erythrocyte morphology
    • presence of large inclusion bodies in red blood cells at E14.5   (MGI Ref ID J:28392)
    • decreased mean corpuscular hemoglobin
      • decreased mean cell hemoglobin content   (MGI Ref ID J:28392)
    • decreased mean corpuscular volume   (MGI Ref ID J:28392)
  • homeostasis/metabolism phenotype
  • hydrops fetalis
    • hydrops fetalis   (MGI Ref ID J:28392)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Hbatm1Paz related

Hematological Research
Hemoglobin Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Hbatm1Paz
Allele Name targeted mutation 1, Chris Paszty
Allele Type Targeted (Null/Knockout)
Common Name(s) Hba0; Hba1-2del;
Mutation Made ByDr. Chris Paszty,   Amgen, Inc.
Strain of Origin129S7/SvEvBrd-Hprt<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt<+>
Gene Symbol and Name Hba, hemoglobin alpha chain complex
Chromosome 11
Molecular Note Both of the adult hemoglobin genes, alpha 1 and alpha 2, and the region between them were deleted and replaced with a neomycin resistance cassette by homologous recombination. [MGI Ref ID J:28392]

Genotyping

Genotyping Information

Genotyping Protocols

Hbatm1Paz, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Paszty C; Mohandas N; Stevens ME; Loring JF; Liebhaber SA; Brion CM; Rubin EM. 1995. Lethal alpha-thalassaemia created by gene targeting in mice and its genetic rescue. Nat Genet 11(1):33-9. [PubMed: 7550311]  [MGI Ref ID J:28392]

Additional References

Paszty C; Brion CM; Manci E; Witkowska HE; Stevens ME; Mohandas N; Rubin EM. 1997. Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease [see comments] Science 278(5339):876-8. [PubMed: 9346488]  [MGI Ref ID J:44161]

Ryan TM; Ciavatta DJ; Townes TM. 1997. Knockout-transgenic mouse model of sickle cell disease [see comments] Science 278(5339):873-6. [PubMed: 9346487]  [MGI Ref ID J:44160]

Hbatm1Paz related

Al-Hasani K; Vadolas J; Knaupp AS; Wardan H; Voullaire L; Williamson R; Ioannou PA. 2005. A 191-kb genomic fragment containing the human alpha-globin locus can rescue alpha-thalassemic mice. Mamm Genome 16(11):847-53. [PubMed: 16284800]  [MGI Ref ID J:103573]

Archer DR; Stiles JK; Newman GW; Quarshie A; Hsu LL; Sayavongsa P; Perry J; Jackson EM; Hibbert JM. 2008. C-reactive protein and interleukin-6 are decreased in transgenic sickle cell mice fed a high protein diet. J Nutr 138(6):1148-52. [PubMed: 18492848]  [MGI Ref ID J:136372]

Banerjee T; Kuypers FA. 2004. Reactive oxygen species and phosphatidylserine externalization in murine sickle red cells. Br J Haematol 124(3):391-402. [PubMed: 14717789]  [MGI Ref ID J:88553]

Barinaga M. 1997. Mutant mice mimic human sickle cell anemia [news; comment] Science 278(5339):803-4. [PubMed: 9381190]  [MGI Ref ID J:44159]

Belcher JD; Mahaseth H; Welch TE; Otterbein LE; Hebbel RP; Vercellotti GM. 2006. Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice. J Clin Invest 116(3):808-16. [PubMed: 16485041]  [MGI Ref ID J:106486]

Bivalacqua TJ; Musicki B; Hsu LL; Berkowitz DE; Champion HC; Burnett AL. 2013. Sildenafil citrate-restored eNOS and PDE5 regulation in sickle cell mouse penis prevents priapism via control of oxidative/nitrosative stress. PLoS One 8(7):e68028. [PubMed: 23844149]  [MGI Ref ID J:204301]

Champion HC; Bivalacqua TJ; Takimoto E; Kass DA; Burnett AL. 2005. Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapism. Proc Natl Acad Sci U S A 102(5):1661-6. [PubMed: 15668387]  [MGI Ref ID J:96103]

Chang J; Patton JT; Sarkar A; Ernst B; Magnani JL; Frenette PS. 2010. GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice. Blood 116(10):1779-86. [PubMed: 20508165]  [MGI Ref ID J:164535]

Chang JC; Ye L; Kan YW. 2006. Correction of the sickle cell mutation in embryonic stem cells. Proc Natl Acad Sci U S A 103(4):1036-40. [PubMed: 16407095]  [MGI Ref ID J:105707]

Chantrathammachart P; Mackman N; Sparkenbaugh E; Wang JG; Parise LV; Kirchhofer D; Key NS; Pawlinski R. 2012. Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease. Blood 120(3):636-46. [PubMed: 22661702]  [MGI Ref ID J:189104]

Chen G; Zhang D; Fuchs TA; Manwani D; Wagner DD; Frenette PS. 2014. Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease. Blood 123(24):3818-27. [PubMed: 24620350]  [MGI Ref ID J:210886]

Dasgupta T; Fabry ME; Kaul DK. 2010. Antisickling property of fetal hemoglobin enhances nitric oxide bioavailability and ameliorates organ oxidative stress in transgenic-knockout sickle mice. Am J Physiol Regul Integr Comp Physiol 298(2):R394-402. [PubMed: 20007516]  [MGI Ref ID J:156179]

Dasgupta T; Hebbel RP; Kaul DK. 2006. Protective effect of arginine on oxidative stress in transgenic sickle mouse models. Free Radic Biol Med 41(12):1771-80. [PubMed: 17157180]  [MGI Ref ID J:116710]

Fabry ME; Suzuka SM; Weinberg RS; Lawrence C; Factor SM; Gilman JG; Costantini F; Nagel RL. 2001. Second generation knockout sickle mice: the effect of HbF. Blood 97(2):410-8. [PubMed: 11154217]  [MGI Ref ID J:66961]

Gavins FN; Russell J; Senchenkova EL; De Almeida Paula L; Damazo AS; Esmon CT; Kirchhofer D; Hebbel RP; Granger DN. 2011. Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S. Blood 117(15):4125-33. [PubMed: 21304105]  [MGI Ref ID J:172840]

Gutsaeva DR; Montero-Huerta P; Parkerson JB; Yerigenahally SD; Ikuta T; Head CA. 2014. Molecular mechanisms underlying synergistic adhesion of sickle red blood cells by hypoxia and low nitric oxide bioavailability. Blood 123(12):1917-26. [PubMed: 24429338]  [MGI Ref ID J:209498]

Gutsaeva DR; Parkerson JB; Yerigenahally SD; Kurz JC; Schaub RG; Ikuta T; Head CA. 2011. Inhibition of cell adhesion by anti-P-selectin aptamer: a new potential therapeutic agent for sickle cell disease. Blood 117(2):727-35. [PubMed: 20926770]  [MGI Ref ID J:168427]

Hanson MS; Xu H; Flewelen TC; Holzhauer SL; Retherford D; Jones DW; Frei AC; Pritchard KA Jr; Hillery CA; Hogg N; Wandersee NJ. 2013. A novel hemoglobin-binding peptide reduces cell-free hemoglobin in murine hemolytic anemia. Am J Physiol Heart Circ Physiol 304(2):H328-36. [PubMed: 23125208]  [MGI Ref ID J:192837]

Hebbel RP; Vercellotti GM; Pace BS; Solovey AN; Kollander R; Abanonu CF; Nguyen J; Vineyard JV; Belcher JD; Abdulla F; Osifuye S; Eaton JW; Kelm RJ Jr; Slungaard A. 2010. The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice. Blood 115(12):2483-90. [PubMed: 20053759]  [MGI Ref ID J:159262]

Hidalgo A; Chang J; Jang JE; Peired AJ; Chiang EY; Frenette PS. 2009. Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury. Nat Med 15(4):384-91. [PubMed: 19305412]  [MGI Ref ID J:149370]

Hsu LL; Champion HC; Campbell-Lee SA; Bivalacqua TJ; Manci EA; Diwan BA; Schimel DM; Cochard AE; Wang X; Schechter AN; Noguchi CT; Gladwin MT. 2007. Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability. Blood 109(7):3088-98. [PubMed: 17158223]  [MGI Ref ID J:145347]

Ieremia J; Blau CA. 2002. Limitations of a mouse model of sickle cell anemia. Blood Cells Mol Dis 28(2):146-51. [PubMed: 12064910]  [MGI Ref ID J:128113]

Kaul DK; Fabry ME; Suzuka SM; Zhang X. 2013. Antisickling fetal hemoglobin reduces hypoxia-inducible factor-1alpha expression in normoxic sickle mice: microvascular implications. Am J Physiol Heart Circ Physiol 304(1):H42-50. [PubMed: 23125209]  [MGI Ref ID J:192836]

Kaul DK; Liu XD; Chang HY; Nagel RL; Fabry ME. 2004. Effect of fetal hemoglobin on microvascular regulation in sickle transgenic-knockout mice. J Clin Invest 114(8):1136-45. [PubMed: 15489961]  [MGI Ref ID J:93424]

Kiefmann R; Rifkind JM; Nagababu E; Bhattacharya J. 2008. Red blood cells induce hypoxic lung inflammation. Blood 111(10):5205-14. [PubMed: 18270324]  [MGI Ref ID J:135569]

Kohli DR; Li Y; Khasabov SG; Gupta P; Kehl LJ; Ericson ME; Nguyen J; Gupta V; Hebbel RP; Simone DA; Gupta K. 2010. Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids. Blood 116(3):456-65. [PubMed: 20304807]  [MGI Ref ID J:162824]

Lagoda G; Sezen SF; Hurt KJ; Cabrini MR; Mohanty DK; Burnett AL. 2014. Sustained nitric oxide (NO)-releasing compound reverses dysregulated NO signal transduction in priapism. FASEB J 28(1):76-84. [PubMed: 24076963]  [MGI Ref ID J:206623]

Lebensburger JD; Howard T; Hu Y; Pestina TI; Gao G; Johnson M; Zakharenko SS; Ware RE; Tuomanen EI; Persons DA; Rosch JW. 2012. Hydroxyurea therapy of a murine model of sickle cell anemia inhibits the progression of pneumococcal disease by down-modulating E-selectin. Blood 119(8):1915-21. [PubMed: 22130804]  [MGI Ref ID J:181749]

Levasseur DN; Ryan TM; Pawlik KM; Townes TM. 2003. Correction of a mouse model of sickle cell disease: lentiviral/antisickling beta-globin gene transduction of unmobilized, purified hematopoietic stem cells. Blood 102(13):4312-9. [PubMed: 12933581]  [MGI Ref ID J:134982]

Li J; Kim K; Hahm E; Molokie R; Hay N; Gordeuk VR; Du X; Cho J. 2014. Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation. J Clin Invest 124(4):1483-96. [PubMed: 24642468]  [MGI Ref ID J:209590]

Liu S; McConnell SC; Ryan TM. 2013. Erythropoiesis in the absence of adult hemoglobin. Mol Cell Biol 33(11):2241-51. [PubMed: 23530053]  [MGI Ref ID J:204029]

Manci EA; Hillery CA; Bodian CA; Zhang ZG; Lutty GA; Coller BS. 2006. Pathology of Berkeley sickle cell mice: similarities and differences with human sickle cell disease. Blood 107(4):1651-8. [PubMed: 16166585]  [MGI Ref ID J:129356]

Meiler SE; Wade M; Kutlar F; Yerigenahally SD; Xue Y; Moutouh-de Parseval LA; Corral LG; Swerdlow PS; Kutlar A. 2011. Pomalidomide augments fetal hemoglobin production without the myelosuppressive effects of hydroxyurea in transgenic sickle cell mice. Blood 118(4):1109-12. [PubMed: 21536862]  [MGI Ref ID J:174901]

Mi T; Abbasi S; Zhang H; Uray K; Chunn JL; Xia LW; Molina JG; Weisbrodt NW; Kellems RE; Blackburn MR; Xia Y. 2008. Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling. J Clin Invest 118(4):1491-501. [PubMed: 18340377]  [MGI Ref ID J:135978]

Noguchi CT; Gladwin M; Diwan B; Merciris P; Smith R; Yu X; Buzard G; Fitzhugh A; Keefer LK; Schechter AN; Mohandas N. 2001. Pathophysiology of a sickle cell trait mouse model: human alpha(beta)(S) transgenes with one mouse beta-globin allele. Blood Cells Mol Dis 27(6):971-7. [PubMed: 11831863]  [MGI Ref ID J:128124]

Paszty C; Brion CM; Manci E; Witkowska HE; Stevens ME; Mohandas N; Rubin EM. 1997. Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease [see comments] Science 278(5339):876-8. [PubMed: 9346488]  [MGI Ref ID J:44161]

Prado GN; Romero JR; Rivera A. 2013. Endothelin-1 receptor antagonists regulate cell surface-associated protein disulfide isomerase in sickle cell disease. FASEB J 27(11):4619-29. [PubMed: 23913858]  [MGI Ref ID J:203687]

Pritchard KA Jr; Feroah TR; Nandedkar SD; Holzhauer SL; Hutchins W; Schulte ML; Strunk RC; Debaun MR; Hillery CA. 2012. Effects of experimental asthma on inflammation and lung mechanics in sickle cell mice. Am J Respir Cell Mol Biol 46(3):389-96. [PubMed: 22033263]  [MGI Ref ID J:194579]

Pritchard KA Jr; Ou J; Ou Z; Shi Y; Franciosi JP; Signorino P; Kaul S; Ackland-Berglund C; Witte K; Holzhauer S; Mohandas N; Guice KS; Oldham KT; Hillery CA. 2004. Hypoxia-induced acute lung injury in murine models of sickle cell disease. Am J Physiol Lung Cell Mol Physiol 286(4):L705-14. [PubMed: 12972407]  [MGI Ref ID J:134696]

Romero JR; Suzuka SM; Nagel RL; Fabry ME. 2004. Expression of HbC and HbS, but not HbA, results in activation of K-Cl cotransport activity in transgenic mouse red cells. Blood 103(6):2384-90. [PubMed: 14615383]  [MGI Ref ID J:88563]

Russell JE; Liebhaber SA. 1998. Reversal of lethal alpha- and beta-thalassemias in mice by expression of human embryonic globins. Blood 92(9):3057-63. [PubMed: 9787139]  [MGI Ref ID J:114200]

Ryan TM; Ciavatta DJ; Townes TM. 1997. Knockout-transgenic mouse model of sickle cell disease [see comments] Science 278(5339):873-6. [PubMed: 9346487]  [MGI Ref ID J:44160]

Solovey A; Kollander R; Shet A; Milbauer LC; Choong S; Panoskaltsis-Mortari A; Blazar BR; Kelm RJ Jr; Hebbel RP. 2004. Endothelial cell expression of tissue factor in sickle mice is augmented by hypoxia/reoxygenation and inhibited by lovastatin. Blood 104(3):840-6. [PubMed: 15073034]  [MGI Ref ID J:92287]

Sparkenbaugh EM; Chantrathammachart P; Mickelson J; van Ryn J; Hebbel RP; Monroe DM; Mackman N; Key NS; Pawlinski R. 2014. Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease. Blood 123(11):1747-56. [PubMed: 24449213]  [MGI Ref ID J:209655]

Sundaram N; Tailor A; Mendelsohn L; Wansapura J; Wang X; Higashimoto T; Pauciulo MW; Gottliebson W; Kalra VK; Nichols WC; Kato GJ; Malik P. 2010. High levels of placenta growth factor in sickle cell disease promote pulmonary hypertension. Blood 116(1):109-12. [PubMed: 20335221]  [MGI Ref ID J:162823]

Vincent L; Vang D; Nguyen J; Gupta M; Luk K; Ericson ME; Simone DA; Gupta K. 2013. Mast cell activation contributes to sickle cell pathobiology and pain in mice. Blood 122(11):1853-62. [PubMed: 23775718]  [MGI Ref ID J:202290]

Voon HP; Wardan H; Vadolas J. 2007. Co-inheritance of alpha- and beta-thalassaemia in mice ameliorates thalassaemic phenotype. Blood Cells Mol Dis 39(2):184-8. [PubMed: 17493845]  [MGI Ref ID J:141719]

Wallace HA; Marques-Kranc F; Richardson M; Luna-Crespo F; Sharpe JA; Hughes J; Wood WG; Higgs DR; Smith AJ. 2007. Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence. Cell 128(1):197-209. [PubMed: 17218265]  [MGI Ref ID J:117887]

Wen J; Jiang X; Dai Y; Zhang Y; Tang Y; Sun H; Mi T; Phatarpekar PV; Kellems RE; Blackburn MR; Xia Y. 2010. Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling. FASEB J 24(3):740-9. [PubMed: 19858092]  [MGI Ref ID J:158034]

Whitney JB; Russell ES. 1978. New mutants and biochemical variants: Alpha thalassemia Mouse News Lett 58:47-48.  [MGI Ref ID J:45721]

Wood KC; Hebbel RP; Granger DN. 2005. Endothelial cell NADPH oxidase mediates the cerebral microvascular dysfunction in sickle cell transgenic mice. FASEB J 19(8):989-91. [PubMed: 15923406]  [MGI Ref ID J:128246]

Wood KC; Hebbel RP; Granger DN. 2004. Endothelial cell P-selectin mediates a proinflammatory and prothrombogenic phenotype in cerebral venules of sickle cell transgenic mice. Am J Physiol Heart Circ Physiol 286(5):H1608-14. [PubMed: 14704223]  [MGI Ref ID J:95603]

Xu J; Peng C; Sankaran VG; Shao Z; Esrick EB; Chong BG; Ippolito GC; Fujiwara Y; Ebert BL; Tucker PW; Orkin SH. 2011. Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science 334(6058):993-6. [PubMed: 21998251]  [MGI Ref ID J:177861]

Zhang Y; Dai Y; Wen J; Zhang W; Grenz A; Sun H; Tao L; Lu G; Alexander DC; Milburn MV; Carter-Dawson L; Lewis DE; Zhang W; Eltzschig HK; Kellems RE; Blackburn MR; Juneja HS; Xia Y. 2011. Detrimental effects of adenosine signaling in sickle cell disease. Nat Med 17(1):79-86. [PubMed: 21170046]  [MGI Ref ID J:168473]

de Jong K; Emerson RK; Butler J; Bastacky J; Mohandas N; Kuypers FA. 2001. Short survival of phosphatidylserine-exposing red blood cells in murine sickle cell anemia. Blood 98(5):1577-84. [PubMed: 11520810]  [MGI Ref ID J:131515]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2140.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2782.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Wild-type from the colony
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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