Strain Name:

B6.129S2-Tnfrsf1btm1Mwm/J

Stock Number:

002620

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Availability:

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This strain is deficient of tumor necrosis factor receptor superfamily, member 1b (Tnfrsf1b), and are consequently resistant to TNF-induced cell death.

Description

Strain Information

Former Names TNFR2 (2733)    (Changed: 15-DEC-04 )
Tnfr2    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
Background Strain C57BL/6
Donor Strain 129S2 via D3 ES cell line
GenerationN10F40 (11-DEC-13)
Generation Definitions
 
Donating InvestigatorDr. Mark W. Moore,   Deltagen

Appearance
black
Related Genotype: a/a

Description
Mice homozygous for a Tnfrsf1btm1Mwm targeted mutation (formerly Tnfr2tm1Mwm, p75 deficient) are viable and fertile. Homozygous mutant mice show normal T-cell development and activity, but are resistant to TNF-induced cell death. Subcutaneous injections of TNF into homozygotes elicit much less tissue necrosis.

Development
This strain was developed by using homologous recombination techniques to target the Tnfr2 gene. The inserted construct contained a neomycin resistance gene under the control of the Pgk promoter and was inserted into the second exon of the Tnfr2 gene.

A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 1 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Tnfrsf1b
003246   B6.129S7-Tnfrsf1btm1Imx/J
003243   B6;129S-Tnfrsf1atm1Imx Tnfrsf1btm1Imx/J
View Strains carrying other alleles of Tnfrsf1b     (2 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm

        B6.129S2-Tnfrsf1btm1Mwm/J
  • immune system phenotype
  • decreased T cell proliferation
    • proliferation of lymph node T cells is reduced in response to anti-CD3e monoclonal antibody stimulation as compared to wild-type   (MGI Ref ID J:107039)
    • purified CD8+ T cells require a 5 fold greater anti-CD3 stimulation for tritiated thymidine incorporation equivalent to wild-type, however proliferation is increased in the presence of IL2   (MGI Ref ID J:107039)
    • purified CD4+ T cells require a greater anti-CD3 stimulation for tritiated thymidine incorporation, however proliferation is increased in the presence of IL2   (MGI Ref ID J:107039)
  • decreased interferon-gamma secretion
    • CD8+ T cells produce less interferon gamma following anti-CD3 stimulation than control cells; the result of fewer cells expressing interferon gamma as well as a decrease in the amount produced per cell   (MGI Ref ID J:107039)
  • decreased interleukin-2 secretion
    • CD8+ T cells exhibit a reduction in IL2 secretion following anti-CD3 stimulation   (MGI Ref ID J:107039)
  • hematopoietic system phenotype
  • decreased T cell proliferation
    • proliferation of lymph node T cells is reduced in response to anti-CD3e monoclonal antibody stimulation as compared to wild-type   (MGI Ref ID J:107039)
    • purified CD8+ T cells require a 5 fold greater anti-CD3 stimulation for tritiated thymidine incorporation equivalent to wild-type, however proliferation is increased in the presence of IL2   (MGI Ref ID J:107039)
    • purified CD4+ T cells require a greater anti-CD3 stimulation for tritiated thymidine incorporation, however proliferation is increased in the presence of IL2   (MGI Ref ID J:107039)

Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm

        B6.129S2-Tnfrsf1btm1Mwm
  • nervous system phenotype
  • abnormal central nervous system regeneration
    • 7 days after traumatic spinal cord injury increased cell death is seen in the center of the lesion and the rostrocaudal spread of the lesion is increased compared to wild-type   (MGI Ref ID J:71178)
    • 4 weeks after traumatic spinal cord injury locomotor performance is significantly more impaired but lesions are not significantly longer than in wild-type mice   (MGI Ref ID J:71178)
  • behavior/neurological phenotype
  • abnormal sleep pattern
    • mice exhibit reduced rapid eye movement (REM) sleep episode frequency compared with wild-type mice   (MGI Ref ID J:103266)
    • after sleep deprivation, mice exhibit a greater increase in fast 'slow waves' compared with wild-type mice   (MGI Ref ID J:103266)
    • however, a decrease in non-REM sleep episode frequency is compensated by extension of non-REM sleep episode duration   (MGI Ref ID J:103266)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm

        involves: 129S2/SvPas * C57BL/6J
  • immune system phenotype
  • abnormal immune system physiology
    • decreased sensitivity to exogenous tumor necrosis factor (TNF), however, death occurs at high doses   (MGI Ref ID J:21815)
    • increased susceptibility to bacterial infection
      • increased mortality as compared to wild-type following injection with Listeria monocytogenes   (MGI Ref ID J:21815)

Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm

        involves: 129S2/SvPas * C57BL/6J * NOD
  • immune system phenotype
  • decreased susceptibility to autoimmune diabetes
    • none of the animals develop diabetes until 24 weeks (no blood glucose measure of >300 mg/dl)   (MGI Ref ID J:64051)
  • periinsulitis
    • at 5 weeks, mice exhibit periinsulits, while transgenic littermates show severe insulitis   (MGI Ref ID J:64051)
  • endocrine/exocrine gland phenotype
  • periinsulitis
    • at 5 weeks, mice exhibit periinsulits, while transgenic littermates show severe insulitis   (MGI Ref ID J:64051)

Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm

        involves: 129S2/SvPas * C57BL/6
  • immune system phenotype
  • decreased susceptibility to bacterial infection
    • mice exhibit reduced Pseudomonas aerugiosa exotoxin-induced liver failure compared with similarly treated wild-type mice   (MGI Ref ID J:50903)
  • increased susceptibility to experimental autoimmune encephalomyelitis
    • following treatment with MOG   (MGI Ref ID J:115225)
  • increased susceptibility to parasitic infection
    • T. gondii-exposed mice exhibit increased bacterial load compared with similarly treated wild-type mice   (MGI Ref ID J:114203)
    • however, recruitment and intracerebral cell movement is normal in T. gondii-exposed mice   (MGI Ref ID J:114203)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Tnfrsf1btm1Mwm related

Apoptosis Research
Death Receptors

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines
Inflammation

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tnfrsf1btm1Mwm
Allele Name targeted mutation 1, Mark Moore
Allele Type Targeted (Null/Knockout)
Common Name(s) TNF-R2-; TNFR II -; TNFR20; TNFRp75-; Tnfr2tm1Mwm; p75-; p75TNFR2-;
Mutation Made ByDr. Mark Moore,   Deltagen
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Tnfrsf1b, tumor necrosis factor receptor superfamily, member 1b
Chromosome 4
Gene Common Name(s) CD120b; TBPII; TNF-R-II; TNF-R2; TNF-R75; TNF-alphaR2; TNFBR; TNFR1B; TNFR2; TNFR80; TNFRII; TNFalpha-R2; Tnfr-1; Tnfr2; p75; p75 TNFR; p75TNFR; tumor necrosis factor receptor 1; tumor necrosis factor receptor 2;
Molecular Note Exon 2, which codes for the signal peptide region, was disrupted by the insertion of a neomycin cassette. To confirm that the gene was correctly targeted, mice were challenged with lipopolysaccharide (LPS) which results in shedding of the Tnfrsf1b extracellular domian in wild-type mice. No soluble Tnfrsf1b was detected in the serum of homozygous mutant animals. [MGI Ref ID J:21815]

Genotyping

Genotyping Information

Genotyping Protocols

Tnfrsf1btm1 Mwm MCA, Melt Curve Analysis
Tnfrsf1btm1Mwm, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Erickson SL; de Sauvage FJ; Kikly K; Carver-Moore K; Pitts-Meek S; Gillett N; Sheehan KC; Schreiber RD; Goeddel DV; Moore MW. 1994. Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice. Nature 372(6506):560-3. [PubMed: 7990930]  [MGI Ref ID J:21815]

Additional References

Balasa B; Van Gunst K; Jung N; Balakrishna D; Santamaria P; Hanafusa T; Itoh N; Sarvetnick N. 2000. Islet-specific expression of IL-10 promotes diabetes in nonobese diabetic mice independent of Fas, perforin, TNF receptor-1, and TNF receptor-2 molecules. J Immunol 165(5):2841-9. [PubMed: 10946317]  [MGI Ref ID J:64051]

Jung KC; Park WS; Kim HJ; Choi EY; Kook MC; Lee HW; Bae Y. 2004. TCR-independent and caspase-independent apoptosis of murine thymocytes by CD24 cross-linking. J Immunol 172(2):795-802. [PubMed: 14707049]  [MGI Ref ID J:87358]

Kalb A; Bluethmann H; Moore MW; Lesslauer W. 1996. Tumor necrosis factor receptors (Tnfr) in mouse fibroblasts deficient in Tnfr1 or Tnfr2 are signaling competent and activate the mitogen-activated protein kinase pathway with differential kinetics. J Biol Chem 271(45):28097-104. [PubMed: 8910423]  [MGI Ref ID J:36624]

Kim GM; Xu J; Xu J; Song SK; Yan P; Ku G; Xu XM; Hsu CY. 2001. Tumor necrosis factor receptor deletion reduces nuclear factor-kappaB activation, cellular inhibitor of apoptosis protein 2 expression, and functional recovery after traumatic spinal cord injury. J Neurosci 21(17):6617-25. [PubMed: 11517251]  [MGI Ref ID J:71178]

Pryhuber GS; O'Brien DP; Baggs R; Phipps R; Huyck H; Sanz I; Nahm MH. 2000. Ablation of tumor necrosis factor receptor type I (p55) alters oxygen-induced lung injury. Am J Physiol Lung Cell Mol Physiol 278(5):L1082-90. [PubMed: 10781441]  [MGI Ref ID J:62347]

Riehl TE; Newberry RD; Lorenz RG; Stenson WF. 2004. TNFR1 mediates the radioprotective effects of lipopolysaccharide in the mouse intestine. Am J Physiol Gastrointest Liver Physiol 286(1):G166-73. [PubMed: 14525729]  [MGI Ref ID J:87602]

Turner SJ; La Gruta NL; Stambas J; Diaz G; Doherty PC. 2004. Differential tumor necrosis factor receptor 2-mediated editing of virus-specific CD8+ effector T cells. Proc Natl Acad Sci U S A 101(10):3545-50. [PubMed: 14993609]  [MGI Ref ID J:90265]

Tnfrsf1btm1Mwm related

Abu-Amer Y; Ross FP; Edwards J; Teitelbaum SL. 1997. Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor. J Clin Invest 100(6):1557-65. [PubMed: 9294124]  [MGI Ref ID J:43048]

Akassoglou K; Bauer J; Kassiotis G; Pasparakis M; Lassmann H; Kollias G; Probert L. 1998. Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy. Am J Pathol 153(3):801-13. [PubMed: 9736029]  [MGI Ref ID J:106592]

Alexopoulou L; Pasparakis M; Kollias G. 1997. A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling. Eur J Immunol 27(10):2588-92. [PubMed: 9368614]  [MGI Ref ID J:43603]

Allen HL; Deepe GS Jr. 2005. Apoptosis modulates protective immunity to the pathogenic fungus Histoplasma capsulatum. J Clin Invest 115(10):2875-85. [PubMed: 16151533]  [MGI Ref ID J:101533]

Allie N; Alexopoulou L; Quesniaux VJ; Fick L; Kranidioti K; Kollias G; Ryffel B; Jacobs M. 2008. Protective role of membrane tumour necrosis factor in the host's resistance to mycobacterial infection. Immunology 125(4):522-34. [PubMed: 18544042]  [MGI Ref ID J:144439]

Amerio P; Toto P; Feliciani C; Suzuki H; Shivji G; Wang B; Sauder DN. 2001. Rethinking the role of tumour necrosis factor-alpha in ultraviolet (UV) B-induced immunosuppression: altered immune response in UV-irradiated TNFR1R2 gene-targeted mutant mice. Br J Dermatol 144(5):952-7. [PubMed: 11359380]  [MGI Ref ID J:103298]

Bachmann R; Eugster HP; Frei K; Fontana A; Lassmann H. 1999. Impairment of TNF-receptor-1 signaling but not fas signaling diminishes T-cell apoptosis in myelin oligodendrocyte glycoprotein peptide-induced chronic demyelinating autoimmune encephalomyelitis in mice. Am J Pathol 154(5):1417-22. [PubMed: 10329594]  [MGI Ref ID J:114241]

Balasa B; Van Gunst K; Jung N; Balakrishna D; Santamaria P; Hanafusa T; Itoh N; Sarvetnick N. 2000. Islet-specific expression of IL-10 promotes diabetes in nonobese diabetic mice independent of Fas, perforin, TNF receptor-1, and TNF receptor-2 molecules. J Immunol 165(5):2841-9. [PubMed: 10946317]  [MGI Ref ID J:64051]

Bohatschek M; Kloss CU; Hristova M; Pfeffer K; Raivich G. 2004. Microglial major histocompatibility complex glycoprotein-1 in the axotomized facial motor nucleus: regulation and role of tumor necrosis factor receptors 1 and 2. J Comp Neurol 470(4):382-99. [PubMed: 14961564]  [MGI Ref ID J:109424]

Calzascia T; Pellegrini M; Hall H; Sabbagh L; Ono N; Elford AR; Mak TW; Ohashi PS. 2007. TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice. J Clin Invest 117(12):3833-45. [PubMed: 17992258]  [MGI Ref ID J:130779]

Carballo E; Blackshear PJ. 2001. Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome. Blood 98(8):2389-95. [PubMed: 11588035]  [MGI Ref ID J:72219]

Carballo E; Lai WS; Blackshear PJ. 2000. Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability. Blood 95(6):1891-9. [PubMed: 10706852]  [MGI Ref ID J:110360]

Carpentier PA; Dingman AL; Palmer TD. 2011. Placental TNF-alpha Signaling in Illness-Induced Complications of Pregnancy. Am J Pathol 178(6):2802-10. [PubMed: 21641402]  [MGI Ref ID J:173471]

Chen X; Baumel M; Mannel DN; Howard OM; Oppenheim JJ. 2007. Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells. J Immunol 179(1):154-61. [PubMed: 17579033]  [MGI Ref ID J:149421]

Chen X; Wu X; Zhou Q; Howard OM; Netea MG; Oppenheim JJ. 2013. TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment. J Immunol 190(3):1076-84. [PubMed: 23277487]  [MGI Ref ID J:193029]

Chien H; Dix RD. 2012. Evidence for multiple cell death pathways during development of experimental cytomegalovirus retinitis in mice with retrovirus-induced immunosuppression: apoptosis, necroptosis, and pyroptosis. J Virol 86(20):10961-78. [PubMed: 22837196]  [MGI Ref ID J:196525]

Coursey TG; Chen PW; Niederkorn JY. 2011. Abrogating TNF-{alpha} Expression Prevents Bystander Destruction of Normal Tissues during iNOS-Mediated Elimination of Intraocular Tumors. Cancer Res 71(7):2445-54. [PubMed: 21307132]  [MGI Ref ID J:170908]

D'Mello C ; Le T ; Swain MG. 2009. Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation. J Neurosci 29(7):2089-102. [PubMed: 19228962]  [MGI Ref ID J:146590]

Deboer T; Fontana A; Tobler I. 2002. Tumor necrosis factor (TNF) ligand and TNF receptor deficiency affects sleep and the sleep EEG. J Neurophysiol 88(2):839-46. [PubMed: 12163535]  [MGI Ref ID J:103266]

Deckert-Schluter M; Bluethmann H; Kaefer N; Rang A; Schluter D. 1999. Interferon-gamma receptor-mediated but not tumor necrosis factor receptor type 1- or type 2-mediated signaling is crucial for the activation of cerebral blood vessel endothelial cells and microglia in murine Toxoplasma encephalitis. Am J Pathol 154(5):1549-61. [PubMed: 10329607]  [MGI Ref ID J:114203]

Deckert-Schluter M; Bluethmann H; Rang A; Hof H; Schluter D. 1998. Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis. J Immunol 160(7):3427-36. [PubMed: 9531303]  [MGI Ref ID J:46621]

Dekaris I; Zhu SN; Dana MR. 1999. TNF-alpha regulates corneal Langerhans cell migration. J Immunol 162(7):4235-9. [PubMed: 10201952]  [MGI Ref ID J:111008]

Dissanayake D; Hall H; Berg-Brown N; Elford AR; Hamilton SR; Murakami K; Deluca LS; Gommerman JL; Ohashi PS. 2011. Nuclear factor-kappaB1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells. Nat Med 17(12):1663-7. [PubMed: 22081022]  [MGI Ref ID J:180207]

Doherty TM; Sher A. 1997. Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection. J Immunol 158(10):4822-31. [PubMed: 9144497]  [MGI Ref ID J:40202]

Douni E; Kollias G. 1998. A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF-R. J Exp Med 188(7):1343-52. [PubMed: 9763613]  [MGI Ref ID J:114744]

Duerrschmid C; Crawford JR; Reineke E; Taffet GE; Trial J; Entman ML; Haudek SB. 2013. TNF receptor 1 signaling is critically involved in mediating angiotensin-II-induced cardiac fibrosis. J Mol Cell Cardiol 57:59-67. [PubMed: 23337087]  [MGI Ref ID J:213255]

Eugster HP; Frei K; Bachmann R; Bluethmann H; Lassmann H; Fontana A. 1999. Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1. Eur J Immunol 29(2):626-32. [PubMed: 10064079]  [MGI Ref ID J:115225]

Feng Y; Teitelbaum DH. 2013. Tumour necrosis factor--induced loss of intestinal barrier function requires TNFR1 and TNFR2 signalling in a mouse model of total parenteral nutrition. J Physiol 591(Pt 15):3709-23. [PubMed: 23753529]  [MGI Ref ID J:212137]

Finck BN; Johnson RW. 2000. Tumor necrosis factor (TNF)-alpha induces leptin production through the p55 TNF receptor. Am J Physiol Regul Integr Comp Physiol 278(2):R537-43. [PubMed: 10666158]  [MGI Ref ID J:114245]

Florido M; Pearl JE; Solache A; Borges M; Haynes L; Cooper AM; Appelberg R. 2005. Gamma interferon-induced T-cell loss in virulent Mycobacterium avium infection. Infect Immun 73(6):3577-86. [PubMed: 15908387]  [MGI Ref ID J:99143]

Fontaine V; Mohand-Said S; Hanoteau N; Fuchs C; Pfizenmaier K; Eisel U. 2002. Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. J Neurosci 22(7):RC216. [PubMed: 11917000]  [MGI Ref ID J:75537]

Funakoshi H; Zacharia LC; Tang Z; Zhang J; Lee LL; Good JC; Herrmann DE; Higuchi Y; Koch WJ; Jackson EK; Chan TO; Feldman AM. 2007. A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction. Circulation 115(17):2307-15. [PubMed: 17438146]  [MGI Ref ID J:130536]

Funk JO; Walczak H; Voigtlander C; Berchtold S; Baumeister T; Rauch P; Rossner S; Steinkasserer A; Schuler G; Lutz MB. 2000. Cutting edge: resistance to apoptosis and continuous proliferation of dendritic cells deficient for TNF receptor-1. J Immunol 165(9):4792-6. [PubMed: 11046001]  [MGI Ref ID J:119158]

Goukassian DA; Qin G; Dolan C; Murayama T; Silver M; Curry C; Eaton E; Luedemann C; Ma H; Asahara T; Zak V; Mehta S; Burg A; Thorne T; Kishore R; Losordo DW. 2007. Tumor necrosis factor-alpha receptor p75 is required in ischemia-induced neovascularization. Circulation 115(6):752-62. [PubMed: 17261656]  [MGI Ref ID J:132332]

Greenfeld CR; Roby KF; Pepling ME; Babus JK; Terranova PF; Flaws JA. 2007. Tumor Necrosis Factor (TNF) Receptor Type 2 Is an Important Mediator of TNF alpha Function in the Mouse Ovary. Biol Reprod 76(2):224-31. [PubMed: 17065602]  [MGI Ref ID J:121169]

Grell M; Becke FM; Wajant H; Mannel DN; Scheurich P. 1998. TNF receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1. Eur J Immunol 28(1):257-63. [PubMed: 9485205]  [MGI Ref ID J:45904]

Guo W; Lasky JL; Chang CJ; Mosessian S; Lewis X; Xiao Y; Yeh JE; Chen JY; Iruela-Arispe ML; Varella-Garcia M; Wu H. 2008. Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation. Nature 453(7194):529-33. [PubMed: 18463637]  [MGI Ref ID J:135172]

Hamid T; Gu Y; Ortines RV; Bhattacharya C; Wang G; Xuan YT; Prabhu SD. 2009. Divergent tumor necrosis factor receptor-related remodeling responses in heart failure: role of nuclear factor-kappaB and inflammatory activation. Circulation 119(10):1386-97. [PubMed: 19255345]  [MGI Ref ID J:166004]

Hensellek S; Brell P; Schaible HG; Brauer R; Segond von Banchet G. 2007. The cytokine TNFalpha increases the proportion of DRG neurones expressing the TRPV1 receptor via the TNFR1 receptor and ERK activation. Mol Cell Neurosci 36(3):381-91. [PubMed: 17851089]  [MGI Ref ID J:126363]

Herrera PL; Harlan DM; Vassalli P. 2000. A mouse CD8 T cell-mediated acute autoimmune diabetes independent of the perforin and Fas cytotoxic pathways: possible role of membrane TNF. Proc Natl Acad Sci U S A 97(1):279-84. [PubMed: 10618409]  [MGI Ref ID J:126142]

Higuchi Y; McTiernan CF; Frye CB; McGowan BS; Chan TO; Feldman AM. 2004. Tumor necrosis factor receptors 1 and 2 differentially regulate survival, cardiac dysfunction, and remodeling in transgenic mice with tumor necrosis factor-alpha-induced cardiomyopathy. Circulation 109(15):1892-7. [PubMed: 15051641]  [MGI Ref ID J:127874]

Huber SA; Sartini D. 2005. Roles of tumor necrosis factor alpha (TNF-alpha) and the p55 TNF receptor in CD1d induction and coxsackievirus B3-induced myocarditis. J Virol 79(5):2659-65. [PubMed: 15708985]  [MGI Ref ID J:96701]

Hui-Yuen JS; Duong TT; Yeung RS. 2006. TNF-alpha is necessary for induction of coronary artery inflammation and aneurysm formation in an animal model of Kawasaki disease. J Immunol 176(10):6294-301. [PubMed: 16670341]  [MGI Ref ID J:131777]

Inoue M; Ross FP; Erdmann JM; Abu-Amer Y; Wei S; Teitelbaum SL. 2000. Tumor necrosis factor alpha regulates alpha(v)beta5 integrin expression by osteoclast precursors in vitro and in vivo. Endocrinology 141(1):284-90. [PubMed: 10614649]  [MGI Ref ID J:59208]

Jacobs M; Brown N; Allie N; Chetty K; Ryffel B. 2000. Tumor necrosis factor receptor 2 plays a minor role for mycobacterial immunity Pathobiology 68(2):68-75. [PubMed: 10878503]  [MGI Ref ID J:63519]

Jaquemar D; Kupriyanov S; Wankell M; Avis J; Benirschke K; Baribault H; Oshima RG. 2003. Keratin 8 protection of placental barrier function. J Cell Biol 161(4):749-56. [PubMed: 12771125]  [MGI Ref ID J:121811]

Ji H; Pettit A; Ohmura K; Ortiz-Lopez A; Duchatelle V; Degott C; Gravallese E; Mathis D; Benoist C. 2002. Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J Exp Med 196(1):77-85. [PubMed: 12093872]  [MGI Ref ID J:132920]

Kafrouni MI; Brown GR; Thiele DL. 2003. The role of TNF-TNFR2 interactions in generation of CTL responses and clearance of hepatic adenovirus infection. J Leukoc Biol 74(4):564-71. [PubMed: 12960267]  [MGI Ref ID J:85969]

Kammertoens T; Qin Z; Briesemeister D; Bendelac A; Blankenstein T. 2012. B-cells and IL-4 promote methylcholanthrene-induced carcinogenesis but there is no evidence for a role of T/NKT-cells and their effector molecules (Fas-ligand, TNF-alpha, perforin). Int J Cancer 131(7):1499-508. [PubMed: 22212899]  [MGI Ref ID J:186111]

Keeton R; Allie N; Dambuza I; Abel B; Hsu NJ; Sebesho B; Randall P; Burger P; Fick E; Quesniaux VF; Ryffel B; Jacobs M. 2014. Soluble TNFRp75 regulates host protective immunity against Mycobacterium tuberculosis. J Clin Invest 124(4):1537-51. [PubMed: 24569452]  [MGI Ref ID J:209719]

Kim EY; Priatel JJ; Teh SJ; Teh HS. 2006. TNF receptor type 2 (p75) functions as a costimulator for antigen-driven T cell responses in vivo. J Immunol 176(2):1026-35. [PubMed: 16393990]  [MGI Ref ID J:126444]

Kim EY; Teh HS. 2004. Critical role of TNF receptor type-2 (p75) as a costimulator for IL-2 induction and T cell survival: a functional link to CD28. J Immunol 173(7):4500-9. [PubMed: 15383581]  [MGI Ref ID J:93724]

Kim EY; Teh HS. 2001. TNF type 2 receptor (p75) lowers the threshold of T cell activation. J Immunol 167(12):6812-20. [PubMed: 11739497]  [MGI Ref ID J:107039]

Kim GM; Xu J; Xu J; Song SK; Yan P; Ku G; Xu XM; Hsu CY. 2001. Tumor necrosis factor receptor deletion reduces nuclear factor-kappaB activation, cellular inhibitor of apoptosis protein 2 expression, and functional recovery after traumatic spinal cord injury. J Neurosci 21(17):6617-25. [PubMed: 11517251]  [MGI Ref ID J:71178]

Kitaura H; Sands MS; Aya K; Zhou P; Hirayama T; Uthgenannt B; Wei S; Takeshita S; Novack DV; Silva MJ; Abu-Amer Y; Ross FP; Teitelbaum SL. 2004. Marrow stromal cells and osteoclast precursors differentially contribute to TNF-alpha-induced osteoclastogenesis in vivo. J Immunol 173(8):4838-46. [PubMed: 15470024]  [MGI Ref ID J:93717]

Kitaura H; Zhou P; Kim HJ; Novack DV; Ross FP; Teitelbaum SL. 2005. M-CSF mediates TNF-induced inflammatory osteolysis. J Clin Invest 115(12):3418-27. [PubMed: 16294221]  [MGI Ref ID J:104533]

Kociok N; Radetzky S; Krohne TU; Gavranic C; Joussen AM. 2006. Pathological but not physiological retinal neovascularization is altered in TNF-Rp55-receptor-deficient mice. Invest Ophthalmol Vis Sci 47(11):5057-65. [PubMed: 17065527]  [MGI Ref ID J:123086]

Kontoyiannis D; Boulougouris G; Manoloukos M; Armaka M; Apostolaki M; Pizarro T; Kotlyarov A; Forster I; Flavell R; Gaestel M; Tsichlis P; Cominelli F; Kollias G. 2002. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med 196(12):1563-74. [PubMed: 12486099]  [MGI Ref ID J:108572]

Kontoyiannis D; Pasparakis M; Pizarro TT; Cominelli F; Kollias G. 1999. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU- rich elements: implications for joint and gut-associated immunopathologies. Immunity 10(3):387-98. [PubMed: 10204494]  [MGI Ref ID J:54056]

Lai CF; Shao JS; Behrmann A; Krchma K; Cheng SL; Towler DA. 2012. TNFR1-activated reactive oxidative species signals up-regulate osteogenic Msx2 programs in aortic myofibroblasts. Endocrinology 153(8):3897-910. [PubMed: 22685265]  [MGI Ref ID J:189093]

Lambertsen KL; Clausen BH; Babcock AA; Gregersen R; Fenger C; Nielsen HH; Haugaard LS; Wirenfeldt M; Nielsen M; Dagnaes-Hansen F; Bluethmann H; Faergeman NJ; Meldgaard M; Deierborg T; Finsen B. 2009. Microglia protect neurons against ischemia by synthesis of tumor necrosis factor. J Neurosci 29(5):1319-30. [PubMed: 19193879]  [MGI Ref ID J:155658]

Le Hir M; Bluethmann H; Kosco-Vilbois MH; Muller M; di Padova F; Moore M; Ryffel B; Eugster HP. 1996. Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signaling. J Exp Med 183(5):2367-72. [PubMed: 8642347]  [MGI Ref ID J:63531]

Lien YC; Noel T; Liu H; Stromberg AJ; Chen KC; St Clair DK. 2006. Phospholipase C-delta1 is a critical target for tumor necrosis factor receptor-mediated protection against adriamycin-induced cardiac injury. Cancer Res 66(8):4329-38. [PubMed: 16618758]  [MGI Ref ID J:108315]

Liu J; Zhao MQ; Xu L; Ramana CV; Declercq W; Vandenabeele P; Enelow RI. 2005. Requirement for tumor necrosis factor-receptor 2 in alveolar chemokine expression depends upon the form of the ligand. Am J Respir Cell Mol Biol 33(5):463-9. [PubMed: 16081883]  [MGI Ref ID J:115449]

Lucas R; Juillard P; Decoster E; Redard M; Burger D; Donati Y; Giroud C; Monso-Hinard C; De Kesel T; Buurman WA; Moore MW; Dayer JM; Fiers W; Bluethmann H; Grau GE. 1997. Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane-bound TNF in experimental cerebral malaria. Eur J Immunol 27(7):1719-25. [PubMed: 9247583]  [MGI Ref ID J:106413]

Luo D; Luo Y; He Y; Zhang H; Zhang R; Li X; Dobrucki WL; Sinusas AJ; Sessa WC; Min W. 2006. Differential functions of tumor necrosis factor receptor 1 and 2 signaling in ischemia-mediated arteriogenesis and angiogenesis. Am J Pathol 169(5):1886-98. [PubMed: 17071609]  [MGI Ref ID J:114980]

Magez S; Radwanska M; Drennan M; Fick L; Baral TN; Allie N; Jacobs M; Nedospasov S; Brombacher F; Ryffel B; De Baetselier P. 2007. Tumor necrosis factor (TNF) receptor-1 (TNFp55) signal transduction and macrophage-derived soluble TNF are crucial for nitric oxide-mediated Trypanosoma congolense parasite killing. J Infect Dis 196(6):954-62. [PubMed: 17703428]  [MGI Ref ID J:145248]

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Markel TA; Crisostomo PR; Wang M; Wang Y; Lahm T; Novotny NM; Tan J; Meldrum DR. 2008. TNFR1 signaling resistance associated with female stem cell cytokine production is independent of TNFR2-mediated pathways. Am J Physiol Regul Integr Comp Physiol 295(4):R1124-30. [PubMed: 18685063]  [MGI Ref ID J:140166]

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Molle C; Zhang T; Ysebrant de Lendonck L; Gueydan C; Andrianne M; Sherer F; Van Simaeys G; Blackshear PJ; Leo O; Goriely S. 2013. Tristetraprolin regulation of interleukin 23 mRNA stability prevents a spontaneous inflammatory disease. J Exp Med 210(9):1675-84. [PubMed: 23940256]  [MGI Ref ID J:202492]

Monden Y; Kubota T; Inoue T; Tsutsumi T; Kawano S; Ide T; Tsutsui H; Sunagawa K. 2007. Tumor necrosis factor-alpha is toxic via receptor 1 and protective via receptor 2 in a murine model of myocardial infarction. Am J Physiol Heart Circ Physiol 293(1):H743-53. [PubMed: 17416608]  [MGI Ref ID J:126031]

Montgomery SL; Mastrangelo MA; Habib D; Narrow WC; Knowlden SA; Wright TW; Bowers WJ. 2011. Ablation of TNF-RI/RII Expression in Alzheimer's Disease Mice Leads to an Unexpected Enhancement of Pathology Implications for Chronic Pan-TNF-alpha Suppressive Therapeutic Strategies in the Brain. Am J Pathol 179(4):2053-70. [PubMed: 21835156]  [MGI Ref ID J:176301]

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Mullarky IK; Szaba FM; Berggren KN; Kummer LW; Wilhelm LB; Parent MA; Johnson LL; Smiley ST. 2006. Tumor necrosis factor alpha and gamma interferon, but not hemorrhage or pathogen burden, dictate levels of protective fibrin deposition during infection. Infect Immun 74(2):1181-8. [PubMed: 16428767]  [MGI Ref ID J:104988]

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Raivich G; Liu ZQ; Kloss CU; Labow M; Bluethmann H; Bohatschek M. 2002. Cytotoxic potential of proinflammatory cytokines: combined deletion of TNF receptors TNFR1 and TNFR2 prevents motoneuron cell death after facial axotomy in adult mouse. Exp Neurol 178(2):186-93. [PubMed: 12504878]  [MGI Ref ID J:118490]

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Sasi SP; Song J; Park D; Enderling H; McDonald JT; Gee H; Garrity B; Shtifman A; Yan X; Walsh K; Natarajan M; Kishore R; Goukassian DA. 2014. TNF-TNFR2/p75 signaling inhibits early and increases delayed nontargeted effects in bone marrow-derived endothelial progenitor cells. J Biol Chem 289(20):14178-93. [PubMed: 24711449]  [MGI Ref ID J:214119]

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Sharma RP; Bhandari N; Riley RT; Voss KA; Meredith FI. 2000. Tolerance to fumonisin toxicity in a mouse strain lacking the P75 tumor necrosis factor receptor. Toxicology 143(2):183-94. [PubMed: 10755704]  [MGI Ref ID J:62392]

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Singh P; Bahrami L; Castillo A; Majid DS. 2013. TNF-alpha type 2 receptor mediates renal inflammatory response to chronic angiotensin II administration with high salt intake in mice. Am J Physiol Renal Physiol 304(7):F991-9. [PubMed: 23389459]  [MGI Ref ID J:195777]

Starcher B. 2000. Role for tumour necrosis factor-alpha receptors in ultraviolet-induced skin tumours. Br J Dermatol 142(6):1140-7. [PubMed: 10848737]  [MGI Ref ID J:103197]

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Steinshamn S; Bemelmans MH; van Tits LJ; Bergh K; Buurman WA; Waage A. 1996. TNF receptors in murine Candida albicans infection: evidence for an important role of TNF receptor p55 in antifungal defense. J Immunol 157(5):2155-9. [PubMed: 8757341]  [MGI Ref ID J:34894]

Tacchini-Cottier F; Vesin C; Redard M; Buurman W; Piguet PF. 1998. Role of TNFR1 and TNFR2 in TNF-induced platelet consumption in mice. J Immunol 160(12):6182-6. [PubMed: 9637537]  [MGI Ref ID J:48034]

Takakuwa T; Knopf HP; Sing A; Carsetti R; Galanos C; Freudenberg MA. 1996. Induction of CD14 expression in Lpsn, Lpsd and tumor necrosis factor receptor-deficient mice. Eur J Immunol 26(11):2686-92. [PubMed: 8921956]  [MGI Ref ID J:36452]

Taubitz A; Schwarz M; Eltrich N; Lindenmeyer MT; Vielhauer V. 2013. Distinct contributions of TNF receptor 1 and 2 to TNF-induced glomerular inflammation in mice. PLoS One 8(7):e68167. [PubMed: 23869211]  [MGI Ref ID J:204416]

Tavener SA; Kubes P. 2006. Cellular and molecular mechanisms underlying LPS-associated myocyte impairment. Am J Physiol Heart Circ Physiol 290(2):H800-6. [PubMed: 16172157]  [MGI Ref ID J:106721]

TeKippe M; Harrison DE; Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp Hematol 31(6):521-7. [PubMed: 12829028]  [MGI Ref ID J:115677]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryThis strain was generated on a mixed 129 and C57BL/6J background. It has been backcrossed to C57BL/6 six times. Homozygotes are viable and fertile. The strain is maintained by mating homozygous siblings. Expected coat color from breeding:Black
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $199.90Female or MaleHomozygous for Tnfrsf1btm1Mwm  
Price per Pair (US dollars $)Pair Genotype
$399.80Homozygous for Tnfrsf1btm1Mwm x Homozygous for Tnfrsf1btm1Mwm  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $259.90Female or MaleHomozygous for Tnfrsf1btm1Mwm  
Price per Pair (US dollars $)Pair Genotype
$519.80Homozygous for Tnfrsf1btm1Mwm x Homozygous for Tnfrsf1btm1Mwm  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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