Description

Strain Information

Type Mutant Stock; Targeted Mutation; Additional information on Genetically Engineered Mutant Mice. Mating System Homozygote x Homozygote         (Female x Male) Species laboratory mouse Generation N2F18N1F8 (10-DEC-07)   Donating Investigator J. Hess,   Merck Research Laboratories

Description
Mice homozygous for the Bdkrb2^tm1Jfh targeted mutation are viable and fertile and display no major defects. Homozygous mutant tissue from the ileum, uterus, and superior cervical ganglia all failed to respond to pharmacological doses of bradykinin. This finding supports the existance of only one type of B2 receptor. B2 deficient mice also display a greater hypertensive response to chronic high sodium intake compared to controls. These mice may be used to study the role of the B2 receptor in hypertension, inflammation, the cardiovascular system, renal function and reproduction.

Control Information

	Control
	101045 B6129SF2/J	(approximate)
Considerations for Choosing Controls

Related Strains

Strains carrying   Bdkrb2^tm1Jfh allele

006860

B6.129-Ins2Akita Bdkrb2tm1Jfh/SmiJ

View Strains carrying   Bdkrb2^tm1Jfh     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh

        involves: 129S7/SvEvBrd * C57BL/6

• normal phenotype
• no abnormal phenotype detected (MGI Ref ID J:25953)
  • mice are viable and fertile; no metabolic, pathological or histopathological abnormalities were detected

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh

        B6.129S7-Bdkrb2^tm1Jfh

• life span-post-weaning/aging
• abnormal induced morbidity/mortality (MGI Ref ID J:121339)
  • increased mortality following renal ischemia/reperfusion procedure (1 of 8) compared to wild-type (0 of 10) and sham controls (0 of 7)
• premature death (MGI Ref ID J:108948)
  • mice have much shorter lifespan than wild-type; 909 days (wt) vs 755 days (mutant)
• renal/urinary system phenotype
• abnormal kidney morphology (MGI Ref ID J:121339)
  • in the kidney of postischimic mice there is more oxidative nuclear and mitochondrial DNA modification than in wild-type but not as severe as in the Bdkrb1/Bdkrb2 double knockout
  • apoptosis rates are increased in postischemic mice compared to in wild-type but not as much as in the Bdkrb1/Bdkrb2 double knockout
• abnormal proximal convoluted tubule morphology (MGI Ref ID J:121339)
  • postischimic mice have more severe histologial changes in renal proximal tubules than in wild-type but not as severe as in the double knockout
• homeostasis/metabolism phenotype
• decreased blood urea nitrogen level (MGI Ref ID J:121339)
  • fasting plasma nitrite/nitrate levels are decreased compared to normal
• increased blood urea nitrogen level (MGI Ref ID J:121339)
  • postischimic mice have increased plasma urea nitrogen compared to wild-type but not as much as in the Bdkrb1/Bdkrb2 double knockout
• increased circulating creatinine level (MGI Ref ID J:121339)
  • postischimic mice have increased plasma creatinine compared to wild-type but not as much as in the Bdkrb1/Bdkrb2 double knockout
• cellular phenotype
• abnormal mitochondrial physiology (MGI Ref ID J:108948)
  • mutant mice show greater mitochondrial damage than wild-type at 12 months of age
• skeleton phenotype
• decreased bone density (MGI Ref ID J:108948)
  • double mutants have significantly bone density compared to wild-type mice
• endocrine/exocrine gland phenotype
• abnormal Leydig cell morphology (MGI Ref ID J:108948)
  • mutant males display some pigmented vacuoles in Leydig cells in the testes at 12 months of age
• reproductive system phenotype
• abnormal Leydig cell morphology (MGI Ref ID J:108948)
  • mutant males display some pigmented vacuoles in Leydig cells in the testes at 12 months of age

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Bdkrb2^tm1Jfh related

Cardiovascular Research
Hypertension (diet-induced)

Immunology and Inflammation Research
Inflammation

Genes & Alleles

Gene & Allele Information

Allele Symbol		Bdkrb2tm1Jfh
Allele Name		targeted mutation 1, J Fred Hess
Allele Type		Targeted (knock-out)
Common Name(s)		B2-; B2R-; BdkrB2; Bk B2R-; Bk2r-; rB2 <->;
Mutation Made By		J. Hess,   Merck Research Laboratories
Strain of Origin		129S7/SvEvBrd-Hprt1
ES Cell Line Name		AB2.1
ES Cell Line Strain		129S7/SvEvBrd-Hprt1
Gene Symbol and Name		Bdkrb2, bradykinin receptor, beta 2
Chromosome		12
Gene Common Name(s)		B(2); B2; B2BKR; B2BRA; B2R; BK-2; BK2; BK2R; BKR2; BRB2; DKFZp686O088; kinin B2;
Molecular Note		A neomycin selection cassette replaced the entire coding sequences of the gene. Binding assays on membranes prepared from ileum tissue of homozygous mice confirmed that no functional protein is produced from this allele. [MGI Ref ID J:25953]

Genotyping

Genotyping Information

Genotyping Protocols

Bdkrb2^tm1Jfh, MCA, vers. 3
Bdkrb2^tm1Jfh, STD PCR, vers. 2

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Borkowski JA; Ransom RW; Seabrook GR; Trumbauer M; Chen H; Hill RG; Strader CD; Hess JF. 1995. Targeted disruption of a B2 bradykinin receptor gene in mice eliminates bradykinin action in smooth muscle and neurons. J Biol Chem 270(23):13706-10. [PubMed: 7775424]  [MGI Ref ID J:25953]

Additional References

Alfie ME; Yang XP; Hess F; Carretero OA. 1996. Salt-sensitive hypertension in bradykinin B2 receptor knockout mice. Biochem Biophys Res Commun 224(3):625-30. [PubMed: 8713099]  [MGI Ref ID J:34497]

Borkowski JA; Hess JF. 1995. Targeted disruption of the mouse B2 bradykinin receptor in embryonic stem cells. Can J Physiol Pharmacol 73(7):773-9. [PubMed: 8846408]  [MGI Ref ID J:29827]

Rupniak NM; Boyce S; Webb JK; Williams AR; Carlson EJ; Hill RG ; Borkowski JA ; Hess JF. 1997. Effects of the bradykinin B1 receptor antagonist des-Arg9[Leu8]bradykinin and genetic disruption of the B2 receptor on nociception in rats and mice. Pain 71(1):89-97. [PubMed: 9200178]  [MGI Ref ID J:41328]

Yosipiv IV; Dipp S; El-Dahr SS. 2001. Targeted disruption of the bradykinin B(2) receptor gene in mice alters the ontogeny of the renin-angiotensin system. Am J Physiol Renal Physiol 281(5):F795-801. [PubMed: 11592936]  [MGI Ref ID J:72552]

Bdkrb2^tm1Jfh related

Abadir PM; Carey RM; Siragy HM. 2003. Angiotensin AT2 receptors directly stimulate renal nitric oxide in bradykinin B2-receptor-null mice. Hypertension 42(4):600-4. [PubMed: 12953015]  [MGI Ref ID J:103114]

Adolfo Arganaraz G; Regina Perosa S; Cristina Lencioni E; Bader M; Abrao Cavalheiro E; da Graca Naffah-Mazzacoratti M; Bosco Pesquero J; Antonio Silva J Jr. 2004. Role of kinin B1 and B2 receptors in the development of pilocarpine model of epilepsy. Brain Res 1013(1):30-9. [PubMed: 15196965]  [MGI Ref ID J:90943]

Alfie ME; Alim S; Mehta D; Shesely EG; Carretero OA. 1999. An enhanced effect of arginine vasopressin in bradykinin B2 receptor null mutant mice. Hypertension 33(6):1436-40. [PubMed: 10373229]  [MGI Ref ID J:56192]

Alfie ME; Yang XP; Hess F; Carretero OA. 1996. Salt-sensitive hypertension in bradykinin B2 receptor knockout mice. Biochem Biophys Res Commun 224(3):625-30. [PubMed: 8713099]  [MGI Ref ID J:34497]

Aliberti J; Viola JP; Vieira-de-Abreu A; Bozza PT; Sher A; Scharfstein J. 2003. Cutting edge: Bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization. J Immunol 170(11):5349-53. [PubMed: 12759407]  [MGI Ref ID J:83453]

Bergaya S; Meneton P; Bloch-Faure M; Mathieu E; Alhenc-Gelas F; Levy BI; Boulanger CM. 2001. Decreased flow-dependent dilation in carotid arteries of tissue kallikrein-knockout mice. Circ Res 88(6):593-9. [PubMed: 11282893]  [MGI Ref ID J:115590]

Bernstein KE; Xiao HD; Frenzel K; Li P; Shen XZ; Adams JW; Fuchs S. 2005. Six truisms concerning ACE and the renin-angiotensin system educed from the genetic analysis of mice. Circ Res 96(11):1135-44. [PubMed: 15947253]  [MGI Ref ID J:109628]

Brochu I; Labonte J; Bkaily G; D'Orleans-Juste P. 2002. Role of endothelin receptors in the hypertensive state of kinin B(2) knockout mice subjected to a high-salt diet. Clin Sci (Lond) 103 Suppl 48:380S-384S. [PubMed: 12193127]  [MGI Ref ID J:103135]

Cervenka L; Harrison-Bernard LM; Dipp S; Primrose G; Imig JD; El-Dahr SS. 1999. Early onset salt-sensitive hypertension in bradykinin B(2) receptor null mice. Hypertension 34(2):176-80. [PubMed: 10454437]  [MGI Ref ID J:88466]

Cervenka L; Vaneckova I; Maly J; Horacek V; El-Dahr SS. 2003. Genetic inactivation of the B2 receptor in mice worsens two-kidney, one-clip hypertension: role of NO and the AT2 receptor. J Hypertens 21(8):1531-8. [PubMed: 12872048]  [MGI Ref ID J:106003]

Duka I; Kintsurashvili E; Gavras I; Johns C; Bresnahan M; Gavras H. 2001. Vasoactive potential of the b(1) bradykinin receptor in normotension and hypertension. Circ Res 88(3):275-81. [PubMed: 11179194]  [MGI Ref ID J:115601]

Duka I; Shenouda S; Johns C; Kintsurashvili E; Gavras I; Gavras H. 2001. Role of the B(2) receptor of bradykinin in insulin sensitivity. Hypertension 38(6):1355-60. [PubMed: 11751717]  [MGI Ref ID J:103241]

El-Dahr SS; Harrison-Bernard LM; Dipp S; Yosipiv IV; Meleg-Smith S. 2000. Bradykinin B2 null mice are prone to renal dysplasia: gene-environment interactions in kidney development Physiol Genomics 3(3):121-31. [PubMed: 11015607]  [MGI Ref ID J:65386]

Emanueli C; Fink E; Milia AF; Salis MB; Conti M; Demontis MP; Madeddu P. 1998. Enhanced blood pressure sensitivity to deoxycorticosterone in mice with disruption of bradykinin B2 receptor gene. Hypertension 31(6):1278-83. [PubMed: 9622142]  [MGI Ref ID J:48384]

Emanueli C; Maestri R; Corradi D; Marchione R; Minasi A; Tozzi MG; Salis MB; Straino S; Capogrossi MC; Olivetti G; Madeddu P. 1999. Dilated and failing cardiomyopathy in bradykinin B(2) receptor knockout mice [see comments] Circulation 100(23):2359-65. [PubMed: 10587341]  [MGI Ref ID J:59835]

Fan H; Harrell JR; Dipp S; Saifudeen Z; El-Dahr SS. 2005. A novel pathological role of p53 in kidney development revealed by gene-environment interactions. Am J Physiol Renal Physiol 288(1):F98-107. [PubMed: 15383401]  [MGI Ref ID J:104678]

Fan H; Stefkova J; El-Dahr SS. 2006. Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway. Am J Physiol Renal Physiol 291(3):F670-82. [PubMed: 16571598]  [MGI Ref ID J:111678]

Han ED; MacFarlane RC; Mulligan AN; Scafidi J; Davis AE rd. 2002. Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor. J Clin Invest 109(8):1057-63. [PubMed: 11956243]  [MGI Ref ID J:76090]

Harrison-Bernard LM; Dipp S; El-Dahr SS. 2003. Renal and blood pressure phenotype in 18-mo-old bradykinin B2R(-/-)CRD mice. Am J Physiol Regul Integr Comp Physiol 285(4):R782-90. [PubMed: 12805091]  [MGI Ref ID J:84494]

Hess JF; Chen RZ; Hey P; Breese R; Chang RS; Chen TB; Bock MG; Vogt T; Pettibone DJ. 2006. Generation and characterization of a humanized bradykinin B1 receptor mouse. Biol Chem 387(2):195-201. [PubMed: 16497152]  [MGI Ref ID J:135789]

Isbell DC; Voros S; Yang Z; DiMaria JM; Berr SS; French BA; Epstein FH; Bishop SP; Wang H; Roy RJ; Kemp BA; Matsubara H; Carey RM; Kramer CM. 2007. Interaction between bradykinin subtype 2 and angiotensin II type 2 receptors during post-MI left ventricular remodeling. Am J Physiol Heart Circ Physiol 293(6):H3372-8. [PubMed: 17933966]  [MGI Ref ID J:132208]

Kakoki M; Kizer CM; Yi X; Takahashi N; Kim HS; Bagnell CR; Edgell CJ; Maeda N; Jennette JC; Smithies O. 2006. Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors. J Clin Invest 116(5):1302-9. [PubMed: 16604193]  [MGI Ref ID J:108948]

Kakoki M; McGarrah RW; Kim HS; Smithies O. 2007. Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury. Proc Natl Acad Sci U S A 104(18):7576-81. [PubMed: 17452647]  [MGI Ref ID J:121339]

Kakoki M; Takahashi N; Jennette JC; Smithies O. 2004. Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor. Proc Natl Acad Sci U S A 101(36):13302-5. [PubMed: 15326315]  [MGI Ref ID J:92403]

Madeddu P; Emanueli C; Gaspa L; Salis B; Milia AF; Chao L; Chao J. 1999. Role of the bradykinin B2 receptor in the maturation of blood pressure phenotype: lesson from transgenic and knockout mice Immunopharmacology 44(1-2):9-13. [PubMed: 10604518]  [MGI Ref ID J:59794]

Madeddu P; Emanueli C; Maestri R; Salis MB; Minasi A; Capogrossi MC; Olivetti G. 2000. Angiotensin II type 1 receptor blockade prevents cardiac remodeling in bradykinin B(2) receptor knockout mice Hypertension 35(1 Pt 2):391-6. [PubMed: 10642330]  [MGI Ref ID J:60047]

Madeddu P; Salis MB; Emanueli C. 1999. Altered baroreflex control of heart rate in bradykinin B2-receptor knockout mice Immunopharmacology 45(1-3):21-7. [PubMed: 10614985]  [MGI Ref ID J:59776]

Madeddu P; Varoni MV; Palomba D; Emanueli C; Demontis MP; Glorioso N; Dessi-Fulgheri P; Sarzani R; Anania V. 1997. Cardiovascular phenotype of a mouse strain with disruption of bradykinin B2-receptor gene. Circulation 96(10):3570-8. [PubMed: 9396457]  [MGI Ref ID J:112265]

Maestri R; Milia AF; Salis MB; Graiani G; Lagrasta C; Monica M; Corradi D; Emanueli C; Madeddu P. 2003. Cardiac hypertrophy and microvascular deficit in kinin B2 receptor knockout mice. Hypertension 41(5):1151-5. [PubMed: 12654715]  [MGI Ref ID J:103026]

Maul B; Krause W; Pankow K; Becker M; Gembardt F; Alenina N; Walther T; Bader M; Siems WE. 2005. Central angiotensin II controls alcohol consumption via its AT1 receptor. FASEB J 19(11):1474-81. [PubMed: 16126915]  [MGI Ref ID J:101196]

Milia AF; Gross V; Plehm R; De Silva JA Jr; Bader M; Luft FC. 2001. Normal blood pressure and renal function in mice lacking the bradykinin B(2) receptor. Hypertension 37(6):1473-9. [PubMed: 11408397]  [MGI Ref ID J:103234]

Monteiro AC; Schmitz V; Svensjo E; Gazzinelli RT; Almeida IC; Todorov A; de Arruda LB; Torrecilhas AC; Pesquero JB; Morrot A; Bouskela E; Bonomo A; Lima AP; Muller-Esterl W; Scharfstein J. 2006. Cooperative activation of TLR2 and bradykinin B2 receptor is required for induction of type 1 immunity in a mouse model of subcutaneous infection by Trypanosoma cruzi. J Immunol 177(9):6325-35. [PubMed: 17056563]  [MGI Ref ID J:140513]

Picard N; Eladari D; El Moghrabi S; Planes C; Bourgeois S; Houillier P; Wang Q; Burnier M; Deschenes G; Knepper MA; Meneton P; Chambrey R. 2008. Defective ENaC processing and function in tissue kallikrein-deficient mice. J Biol Chem 283(8):4602-11. [PubMed: 18086683]  [MGI Ref ID J:132178]

Prediger RD; Medeiros R; Pandolfo P; Duarte FS; Passos GF; Pesquero JB; Campos MM; Calixto JB; Takahashi RN. 2008. Genetic deletion or antagonism of kinin B(1) and B(2) receptors improves cognitive deficits in a mouse model of Alzheimer's disease. Neuroscience 151(3):631-43. [PubMed: 18191900]  [MGI Ref ID J:135258]

Rhaleb NE; Peng H; Alfie ME; Shesely EG; Carretero OA. 1999. Effect of ACE inhibitor on DOCA-salt- and aortic coarctation-induced hypertension in mice: do kinin B2 receptors play a role? Hypertension 33(1 Pt 2):329-34. [PubMed: 9931125]  [MGI Ref ID J:53680]

Rupniak NM; Boyce S; Webb JK; Williams AR; Carlson EJ; Hill RG ; Borkowski JA ; Hess JF. 1997. Effects of the bradykinin B1 receptor antagonist des-Arg9[Leu8]bradykinin and genetic disruption of the B2 receptor on nociception in rats and mice. Pain 71(1):89-97. [PubMed: 9200178]  [MGI Ref ID J:41328]

Schanstra JP; Duchene J; Praddaude F; Bruneval P; Tack I; Chevalier J; Girolami JP; Bascands JL. 2003. Decreased renal NO excretion and reduced glomerular tuft area in mice lacking the bradykinin B2 receptor. Am J Physiol Heart Circ Physiol 284(6):H1904-8. [PubMed: 12560214]  [MGI Ref ID J:83895]

Schanstra JP; Neau E; Drogoz P; Arevalo Gomez MA; Lopez Novoa JM; Calise D; Pecher C; Bader M; Girolami JP; Bascands JL. 2002. In vivo bradykinin B2 receptor activation reduces renal fibrosis. J Clin Invest 110(3):371-9. [PubMed: 12163456]  [MGI Ref ID J:78354]

Shariat-Madar Z; Mahdi F; Warnock M; Homeister JW; Srikanth S; Krijanovski Y; Murphey LJ; Jaffa AA; Schmaier AH. 2006. Bradykinin B2 receptor knockout mice are protected from thrombosis by increased nitric oxide and prostacyclin. Blood 108(1):192-9. [PubMed: 16514058]  [MGI Ref ID J:135575]

Silvestre JS; Bergaya S; Tamarat R; Duriez M; Boulanger CM; Levy BI. 2001. Proangiogenic effect of angiotensin-converting enzyme inhibition is mediated by the bradykinin B(2) receptor pathway. Circ Res 89(8):678-83. [PubMed: 11597990]  [MGI Ref ID J:115630]

Strecker T; Messlinger K; Weyand M; Reeh PW. 2005. Role of different proton-sensitive channels in releasing calcitonin gene-related peptide from isolated hearts of mutant mice. Cardiovasc Res 65(2):405-10. [PubMed: 15639479]  [MGI Ref ID J:101967]

Trabold F; Pons S; Hagege AA; Bloch-Faure M; Alhenc-Gelas F; Giudicelli JF; Richer-Giudicelli C; Meneton P. 2002. Cardiovascular phenotypes of kinin B2 receptor- and tissue kallikrein-deficient mice. Hypertension 40(1):90-5. [PubMed: 12105144]  [MGI Ref ID J:103162]

Trevisani M; Schmidlin F; Tognetto M; Nijkamp FP; Gies JP; Frossard N; Amadesi S; Folkerts G; Geppetti P. 1999. Evidence for in vitro expression of B1 receptor in the mouse trachea and urinary bladder. Br J Pharmacol 126(6):1293-300. [PubMed: 10217521]  [MGI Ref ID J:54390]

Wang H; Kohno T; Amaya F; Brenner GJ; Ito N; Allchorne A; Ji RR; Woolf CJ. 2005. Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission. J Neurosci 25(35):7986-92. [PubMed: 16135755]  [MGI Ref ID J:100473]

Xia CF; Smith RS Jr; Shen B; Yang ZR; Borlongan CV; Chao L; Chao J. 2006. Postischemic brain injury is exacerbated in mice lacking the kinin B2 receptor. Hypertension 47(4):752-61. [PubMed: 16534002]  [MGI Ref ID J:135763]

Xiao HD; Fuchs S; Cole JM; Disher KM; Sutliff RL; Bernstein KE. 2003. Role of bradykinin in angiotensin-converting enzyme knockout mice. Am J Physiol Heart Circ Physiol 284(6):H1969-77. [PubMed: 12637363]  [MGI Ref ID J:83894]

Yang XP; Liu YH; Mehta D; Cavasin MA; Shesely E; Xu J; Liu F; Carretero OA. 2001. Diminished cardioprotective response to inhibition of angiotensin-converting enzyme and angiotensin II type 1 receptor in B(2) kinin receptor gene knockout mice. Circ Res 88(10):1072-9. [PubMed: 11375278]  [MGI Ref ID J:111458]

Yosipiv IV; Dipp S; El-Dahr SS. 2001. Targeted disruption of the bradykinin B(2) receptor gene in mice alters the ontogeny of the renin-angiotensin system. Am J Physiol Renal Physiol 281(5):F795-801. [PubMed: 11592936]  [MGI Ref ID J:72552]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB29

Colony Maintenance

Breeding & Husbandry	This strain is maintained by homozygous sibling matings. Expected coat color from breeding:Black
Mating System	Homozygote x Homozygote         (Female x Male)
Diet Information	LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.

Supply Notes

Usually shipped between four and eight weeks of age. This strain is included in the Induced Mutant Resource Colony collection.

Control Information

	Control
	101045 B6129SF2/J	(approximate)
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Contact Information
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Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license.

Contact information

General inquiries

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phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

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Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.