Strain Name:

C57BL/6-Tg(K6ODCtr)55Tgo/J

Stock Number:

002647

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Strain; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
 
Donating InvestigatorDr. Thomas O'Brien,   The Lankenau Medical Research Center

Appearance
black, hairless
Related Genotype: a/aTgN(K6ODCtr)55Tgo/-

Description
Mice carrying the (K6ODCtr)transgene show skin abnormalities including: alopecia, enhanced nail growth, follicular cysts in the dermis, excessive skin wrinkling and folding, oily skin, acne, and spontaneous squamous skin tumors. This strain may serve as a model for acne or for enhanced susceptibility to skin cancer. Mice homozygous for this transgene are not viable.

Development
The transgene consists of a mutant murine Odc gene with a premature stop codon at position 427, and the minimal promoter from the bovine keratin 6 gene homolog. This strain was developed in the laboratory of Dr. Thomas O'Brien at The Lankenau Medical Research Center.

Control Information

  Control
   Noncarrier
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Odc1
025845   B6N(Cg)-Odc1tm1b(EUCOMM)Hmgu/J
024246   C57BL/6N-Odc1tm1a(EUCOMM)Hmgu/J
View Strains carrying other alleles of Odc1     (2 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Characteristics of this human disease are associated with transgenes and other mutation types in the mouse.
Atrichia with Papular Lesions; APL
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tg(K6ODCtr)55Tgo/0

        C57BL/6-Tg(K6ODCtr)55Tgo/J
  • adipose tissue phenotype
  • decreased subcutaneous adipose tissue amount
    • in older mice, dermal cysts replace the subcutaneous fat layer   (MGI Ref ID J:62356)
  • growth/size/body phenotype
  • decreased body weight
  • endocrine/exocrine gland phenotype
  • enlarged sebaceous gland
    • sebaceous glands are moderately hyperplastic   (MGI Ref ID J:62356)
  • integument phenotype
  • abnormal hair follicle morphology   (MGI Ref ID J:62356)
    • dilated hair follicle infundibulum
      • mice exhibit a dilatation of the hair follicle infundibulum   (MGI Ref ID J:62356)
    • hair follicle degeneration
      • disintegration of the lower portion of the hair follicle   (MGI Ref ID J:62356)
  • abnormal nail morphology
    • mice exhibit excessive nail growth   (MGI Ref ID J:62356)
  • absent vibrissae
    • by 1.5 months of age   (MGI Ref ID J:62356)
  • alopecia
    • by 1.5 months of age, mice exhibit generalized hair loss   (MGI Ref ID J:62356)
    • cysts replace the lower portion of the hair follicle   (MGI Ref ID J:62356)
  • decreased subcutaneous adipose tissue amount
    • in older mice, dermal cysts replace the subcutaneous fat layer   (MGI Ref ID J:62356)
  • dermal cysts
    • cysts replace the lower portion of the hair follicle   (MGI Ref ID J:62356)
    • some cysts have thick walls of stratified squamous epithelium filled with concentrically oriented cornified squames   (MGI Ref ID J:62356)
    • in older mice, dermal cysts replace the subcutaneous fat layer   (MGI Ref ID J:62356)
    • some cysts rupture and form foreign body granulomas   (MGI Ref ID J:62356)
  • enlarged sebaceous gland
    • sebaceous glands are moderately hyperplastic   (MGI Ref ID J:62356)
  • skin lesions
    • mice exhibit comedo-like structures associated with sebaceous glands   (MGI Ref ID J:62356)
  • wrinkled skin
    • as mice age their skin exhibits excessive growth resulting in wrinkling and folding   (MGI Ref ID J:62356)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tg(K6ODCtr)55Tgo/0

        involves: C3H * C57BL/6
  • adipose tissue phenotype
  • decreased subcutaneous adipose tissue amount
    • after three months of age, dermal cysts replace the subcutaneous fat layer   (MGI Ref ID J:29098)
  • growth/size/body phenotype
  • decreased body weight
  • cellular phenotype
  • increased apoptosis
    • in culture, primary keratinocytes undergo premature cell death via apoptosis compared to wild-type cells   (MGI Ref ID J:133302)
    • increased cell density prolongs primary keratinocyte cell life in culture but does not prevent premature death   (MGI Ref ID J:133302)
    • however, treatment with DFMO blocks cell death in cultured primary keratinocytes   (MGI Ref ID J:133302)
  • tumorigenesis
  • increased skin tumor incidence
    • mice develop skin tumors (squamous neoplasms) at a higher rate than wild-type mice   (MGI Ref ID J:29098)
    • however, squamous cell carcinomas are not observed   (MGI Ref ID J:29098)
    • increased skin papilloma incidence
      • mice develop keratoacanthom-like lesions and well-differentiated papillomatous lesions   (MGI Ref ID J:29098)
      • skin tumors are found on the tail, face and ears   (MGI Ref ID J:29098)
  • endocrine/exocrine gland phenotype
  • enlarged sebaceous gland
    • sebaceous glands near dermal cysts are moderately hyperplastic   (MGI Ref ID J:29098)
  • integument phenotype
  • abnormal nail morphology
    • mice exhibit excessive nail growth   (MGI Ref ID J:29098)
  • absent hair follicles
    • after 2 months of age   (MGI Ref ID J:29098)
  • absent vibrissae
    • by 2 months of age   (MGI Ref ID J:29098)
  • alopecia
    • despite a normal first hair cycle, mice exhibit hair loss at 2 to 3 weeks of age   (MGI Ref ID J:29098)
    • mice exhibit complete hair loss by 2 months of age   (MGI Ref ID J:29098)
    • hair loss is a dominant phenotype   (MGI Ref ID J:29098)
  • decreased subcutaneous adipose tissue amount
    • after three months of age, dermal cysts replace the subcutaneous fat layer   (MGI Ref ID J:29098)
  • dermal cysts
    • mice exhibit follicular cysts in the dermis   (MGI Ref ID J:29098)
    • in mice older than 3 months, cysts are very large and replace the subcutaneous fat layer   (MGI Ref ID J:29098)
  • enlarged sebaceous gland
    • sebaceous glands near dermal cysts are moderately hyperplastic   (MGI Ref ID J:29098)
  • increased skin tumor incidence
    • mice develop skin tumors (squamous neoplasms) at a higher rate than wild-type mice   (MGI Ref ID J:29098)
    • however, squamous cell carcinomas are not observed   (MGI Ref ID J:29098)
    • increased skin papilloma incidence
      • mice develop keratoacanthom-like lesions and well-differentiated papillomatous lesions   (MGI Ref ID J:29098)
      • skin tumors are found on the tail, face and ears   (MGI Ref ID J:29098)
  • oily skin
    • develops with age   (MGI Ref ID J:29098)
  • skin lesions
    • mice develop keratoacanthom-like lesions   (MGI Ref ID J:29098)
  • wrinkled skin
    • develops with age   (MGI Ref ID J:29098)

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(K6ODCtr)55Tgo
Allele Name transgene insertion 55, Thomas O'Brien
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) K6/ODC;
Mutation Made ByDr. Thomas O'Brien,   The Lankenau Medical Research Center
Strain of Origin(C57BL/6 x C3H)F2
Expressed Gene Odc1, ornithine decarboxylase, structural 1, mouse, laboratory
Promoter KRT6, keratin 6A, cattle
Molecular Note The transgene consists of a mutant murine Odc1 gene with a premature stop codon at position 427, and the minimal promoter from the bovine keratin 6 gene homolog.
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Tg(K6ODCtr)55Tgo, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Megosh L; Gilmour SK; Rosson D; Soler AP; Blessing M; Sawicki JA; O'Brien TG. 1995. Increased frequency of spontaneous skin tumors in transgenic mice which overexpress ornithine decarboxylase. Cancer Res 55(19):4205-9. [PubMed: 7671221]  [MGI Ref ID J:29098]

Additional References

Morikawa T; Wanibuchi H; Morimura K; Ogawa M; Fukushima S. 2000. Promotion of skin carcinogenesis by dimethylarsinic acid in keratin (K6)/ODC transgenic mice. Jpn J Cancer Res 91(6):579-81. [PubMed: 10874208]  [MGI Ref ID J:62952]

Tg(K6ODCtr)55Tgo related

Chen Y; Megosh LC; Gilmour SK; Sawicki JA; O'Brien TG. 2000. K6/ODC transgenic mice as a sensitive model for carcinogen identification. Toxicol Lett 116(1-2):27-35. [PubMed: 10906419]  [MGI Ref ID J:63568]

George K; Iacobucci A; Uitto J; O'brien TG. 2005. Identification of an X-linked locus modifying mouse skin tumor susceptibility. Mol Carcinog 44(3):212-8. [PubMed: 16086382]  [MGI Ref ID J:101472]

Gilmour SK; Birchler M; Smith MK; Rayca K; Mostochuk J. 1999. Effect of elevated levels of ornithine decarboxylase on cell cycle progression in skin. Cell Growth Differ 10(11):739-48. [PubMed: 10593650]  [MGI Ref ID J:59581]

Hayes CS; Defeo K; Dang H; Trempus CS; Morris RJ; Gilmour SK. 2011. A prolonged and exaggerated wound response with elevated ODC activity mimics early tumor development. Carcinogenesis 32(9):1340-8. [PubMed: 21730362]  [MGI Ref ID J:175554]

Hobbs CA; Wei G; Defeo K; Paul B; Hayes CS; Gilmour SK. 2006. Tip60 Protein Isoforms and Altered Function in Skin and Tumors that Overexpress Ornithine Decarboxylase. Cancer Res 66(16):8116-22. [PubMed: 16912189]  [MGI Ref ID J:113386]

Keough MP; Hayes CS; DeFeo K; Gilmour SK. 2011. Elevated epidermal ornithine decarboxylase activity suppresses contact hypersensitivity. J Invest Dermatol 131(1):158-66. [PubMed: 20844550]  [MGI Ref ID J:180854]

Lan L; Trempus C; Gilmour SK. 2000. Inhibition of ornithine decarboxylase (ODC) decreases tumor vascularization and reverses spontaneous tumors in ODC/Ras transgenic mice Cancer Res 60(20):5696-703. [PubMed: 11059762]  [MGI Ref ID J:65347]

Megosh L; Halpern M; Farkash E; O'Brien TG. 1998. Analysis of ras gene mutational spectra in epidermal papillomas from K6/ODC transgenic mice. Mol Carcinog 22(3):145-9. [PubMed: 9688139]  [MGI Ref ID J:49929]

Miller TJ; Honchel R; Espandiari P; Knapton A; Zhang J; Sistare FD; Hanig JP. 2008. The utility of the K6/ODC transgenic mouse as an alternative short term dermal model for carcinogenicity testing of pharmaceuticals. Regul Toxicol Pharmacol 50(1):87-97. [PubMed: 18069108]  [MGI Ref ID J:133428]

Morikawa T; Wanibuchi H; Morimura K; Ogawa M; Fukushima S. 2000. Promotion of skin carcinogenesis by dimethylarsinic acid in keratin (K6)/ODC transgenic mice. Jpn J Cancer Res 91(6):579-81. [PubMed: 10874208]  [MGI Ref ID J:62952]

O'Brien TG; Megosh LC; Gilliard G; Soler AP. 1997. Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin. Cancer Res 57(13):2630-7. [PubMed: 9205069]  [MGI Ref ID J:41488]

Panteleyev AA; Christiano AM; O'Brien TG; Sundberg JP. 2000. Ornithine decarboxylase transgenic mice as a model for human atrichia with papular lesions Exp Dermatol 9(2):146-51. [PubMed: 10772389]  [MGI Ref ID J:62356]

Peralta Soler A; Gilliard G; Megosh L; George K; O'Brien TG. 1998. Polyamines regulate expression of the neoplastic phenotype in mouse skin. Cancer Res 58(8):1654-9. [PubMed: 9563478]  [MGI Ref ID J:47024]

Smith MK; Trempus CS; Gilmour SK. 1998. Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin. Carcinogenesis 19(8):1409-15. [PubMed: 9744537]  [MGI Ref ID J:50136]

Tang X; Kim AL; Feith DJ; Pegg AE; Russo J; Zhang H; Aszterbaum M; Kopelovich L; Epstein EH Jr; Bickers DR; Athar M. 2004. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice. J Clin Invest 113(6):867-75. [PubMed: 15067319]  [MGI Ref ID J:89218]

Wei G; DeFeo K; Hayes CS; Woster PM; Mandik-Nayak L; Gilmour SK. 2008. Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes. Cancer Res 68(7):2214-22. [PubMed: 18381427]  [MGI Ref ID J:133302]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryThis strain was generated on a mixed C57BL/6 x C3H background. It has been backcrossed 5 times to C57BL/6J and is maintained by mating hemizygous males to normal wildtype females. Expected coat color from breeding:Black and Hairless

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Noncarrier
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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