Strain Name:

B6.C3(Cg)-Rorasg/J

Stock Number:

002651

Availability:

Repository- Live

Description

Strain Information

Former Names B6.Cg-Rorasg/J    (Changed: 25-JUL-06 )
B6.C3-Rorasg/J    (Changed: 24-JUL-06 )
B6.C3(B10)-Rorasg/J    (Changed: 21-JUL-06 )
B6.Cg-Rorasg/J    (Changed: 20-JUL-06 )
Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHeterozygote x Heterozygote         (Female x Male)
PCR typed heterozygote x heterozygote
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain Mixed stock
GenerationNE9F65 (18-DEC-08)

Appearance
black, ataxic, tremors
Related Genotype: a/a Rorasg/Rorasg

black, unaffected
Related Genotype: a/a +/? or a/a Rorasg/+

Description
Mice homozygous for the staggerer spontaneous mutation (Rorasg) show a staggering gait, mild tremor, hypotonia, and small size. The cerebellar cortex of homozygous mutant mice is grossly underdeveloped with a deficiency of granule cells and Purkinje cells. The remaining granule cells migrate inward from the external layer prematurely and then degenerate. Purkinje cells are much delayed in postnatal differentiation and lack the dendritic spines on which synapses with the parallel fibers from the granule cells normally occur. Staggerer mutant mice have been used as a source of an agranulate cerebellum in a number of investigations of the composition and function of granule cells. Kopmels et al. have reported a hyperproduction of IL1 biological activity and mRNA from LPS stimulated spleen cells of Rorasg/Rorasg mice on the C57BL/6J background relative to wild type siblings. In addition, homozygous mice exhibit an enhanced susceptibility to LPS-induced lung inflammation, suggesting a role for Rora in LPS-induced inflammatory responses (Stapleton CM, et al., 2005).

Development
The first Rorasg/Rorasg mouse was observed in 1955 among the F2 progeny of a (BALB/cHm x C3H/HeJ)F1 female and a male of an obese(Lepob) stock of mixed background. The mutation was maintained for several generations by an intercross-backcross (within the same or a parallel lineage) mating scheme, then was backcrossed onto C57BL/6J for four generations. A Rorasg/+ male from the fourth backcross was mated to a female C57BL/10-Myo5ad Bmp5se mouse to introduce the dilute and short-ear mutations into the stock in repulsion with Rora6 sg ; this allowed the heterozygotes (Rorasg + +/+ Myo5ad Bmp5se to be identified by a lack of either recessive phenotype. Brother-sister inbreeding was continued. At F55, Myo5ad Bmpse was backcrossed onto C57BL/6J seven times; at F58, Rorasg was backcrossed onto C57BL/6J four times. The Rorasg + +/+ Myo5ad Bmp5se stock was then reconstructed by crossing mice of the two independent stocks and maintained by brother-sister inbreeding. In early 1997, Myo5ad and Bmp5se were bred out of the stock by selective breeding assisted by PCR testing. Based on the alleles carried by this strain for 16 SSLPs mapping within 1 cM of Rora, it appears that the mutation occurred on a C3H chromosome (Hamilton et al. 1996).

Control Information

  Control
   Typed heterozygote from the colony
   Wild-type from the colony
   Wild type mice from the colony are the preferred controls. Untyped mice from the colony may be used; however, heterozygotes exhibit "accelerated loss of Purkinje cells, granule cells, and inferior olivary neurons with age" (MLC; Zanjani et al.1992; Hadj-Sahraoui et al.1997).
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Rorasg allele
000285   B6.Cg-Rorasg + +/+ Myo5ad Bmp5se/J
000237   B6C3Fe a/a-Rorasg/J
View Strains carrying   Rorasg     (2 strains)

Strains carrying other alleles of Rora
005047   C57BL/6J-Rorasg-3J/J
View Strains carrying other alleles of Rora     (1 strain)

Additional Web Information

Congenic Nomenclature

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Rorasg/Rorasg

        involves: obese stock
  • lethality-postnatal
  • postnatal lethality (MGI Ref ID J:13140)
    • about 50% of mutants die by weaning
  • nervous system phenotype
  • abnormal brain morphology (MGI Ref ID J:13140)
    • abnormal cerebellum morphology (MGI Ref ID J:13140)
      • cerebellum of adults shows tiny folia with indistinct fissures
      • cerebellum is less than one-third the size of wild-type littermates
      • abnormal cerebellar foliation (MGI Ref ID J:13140)
      • abnormal cerebellar granule layer (MGI Ref ID J:13140)
        • granular cell layer displays a paucity of cells in mutants
      • abnormal cerebellar molecular layer (MGI Ref ID J:13140)
        • thin cerebellar molecular layer (MGI Ref ID J:13140)
      • small cerebellum (MGI Ref ID J:13140)
  • behavior/neurological phenotype
  • abnormal motor capabilities/coordination/movement (MGI Ref ID J:13140)
    • abnormal gait (MGI Ref ID J:13140)
      • gait is shuffling and hesitant, interrupted every few steps by lurching motions side-to-side
      • abnormal gait is apparent at ~2 weeks of age
    • abnormal grip strength (MGI Ref ID J:46854)
      • mice have a mean hanging time of 12 seconds compared to over 3 minutes for WT mice
    • abnormal limb posture (MGI Ref ID J:13140)
      • some animals have hindlimbs held abducted and everted at 45 degrees at rest
    • ataxia (MGI Ref ID J:13140)
      • clearly visible in all mice
      • mice stumble at a rate 40 times greater than WT mice
    • hypoactivity (MGI Ref ID J:13140)
      • mutants remain stationary much more than littermates
    • impaired coordination (MGI Ref ID J:13140)
      • mice fall off an elevated rod on average of 13 seconds compared to over 3 minutes for WT mice
    • limb grasping (MGI Ref ID J:46854)
      • is observed in all mice
    • tremors (MGI Ref ID J:13140)
      • mild tremors accompany initiation of movement
  • abnormal motor learning (MGI Ref ID J:46854)
    • mice have an impaired ability to learn how to hang onto a rotating rod
    • mice hang onto the rod as opposed the walking strategy WT mice exclusively use
    • scores do not improve with 10 days of training
  • growth/size phenotype
  • decreased body size (MGI Ref ID J:13140)
    • mutants are smaller than littermates

Rorasg/Rorasg

        involves: C57BL/6
  • homeostasis/metabolism phenotype
  • abnormal lipid homeostasis (MGI Ref ID J:52105)
    • plasma APOA1 and APOA2 concentrations are approximately 2 fold lower than in wild-type controls on a normal diet, and the Apoa1 mRNA level in intestine is diminished relative to wild-type, although liver expression of Apoa1 is comparable with wild-type
    • the production rate of APOA1 is diminished, but the fractional catabolic rate is comparable to wild-type
    • decreased circulating cholesterol level (MGI Ref ID J:52105)
      • plasma total cholesterol levels are significantly lower in both male and female homozygotes than in wild-type controls
      • although cholesterol levels increase on an atherosclerotic diet, homozygotes still have lower plasma cholesterol than wild-type controls also fed this diet
      • decreased circulating HDL cholesterol level (MGI Ref ID J:52105)
        • plasma HDL cholesterol level is significantly lower in both male and female homozygotes than in wild-type controls, and females have significantly lower plasma HDL level than males both for the homozygous and wild-type data sets. This is true even on an atherogenic diet.
  • cardiovascular system phenotype
  • atherosclerotic lesions (MGI Ref ID J:52105)
    • the atherosclerotic lesions induced in homozygotes by 9 weeks of an atherosclerotic diet have a 6 fold greater area in female homozygotes and a 7.5 fold greater area in male homozygotes than those in wild-type controls on the same diet
    • increased susceptibility to atherosclerosis (MGI Ref ID J:52105)
      • Although homozygotes fed a normal diet do not display abnormal atherosclerotic lesions, 9 weeks of an atherosclerotic diet induces exaggerated altherosclerotic lesions compared with wild-type controls on the atherosclerotic diet
  • immune system phenotype
  • *normal* immune system phenotype (MGI Ref ID J:52105)
    • white blood cell, lymphocyte, and neutrophil counts are not significantly different between homozygotes and wild-type controls
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Rorasg related

Neurobiology Research
Ataxia (Movement) Defects
Cerebellar Defects (Purkinje cell defect)
Receptor Defects
Tremor Defects

Genes & Alleles

Gene & Allele Information

 
Allele Symbol Rorasg
Allele Name staggerer
Allele Type Spontaneous
Common Name(s) RORalpha-; sg;
Strain of Originobese stock
Gene Symbol and Name Rora, RAR-related orphan receptor alpha
Chromosome 9
Gene Common Name(s) 9530021D13Rik; DKFZp686M2414; MGC119326; MGC119329; NR1F1; RIKEN cDNA 9530021D13 gene; ROR1; ROR2; ROR3; RZR-ALPHA; RZRA; neuroscience mutagenesis facility, 267; nmf267; sg; staggerer;
General Note Homozygotes for the staggerer mutation show a staggering gait, mild tremor, hypotonia, and small size (J:13140). The cerebellar cortex is grossly underdeveloped with a deficiency of granule cells and Purkinje cells. The deficiency of granule cells in theexternal granular layer is already evident at birth. The remaining granule cells migrate inward from the external layer prematurely and then degenerate (J:5304). Purkinje cells are much delayed in postnatal differentiation and lack the dendritic spines on which synapses with the parallel fibers from the granule cells normally occur (J:5968). Golgi cells are not clearly distinguishable from Purkinje cells and it is possible that their number is also reduced (J:6185). Examination of the cerebellum of chimeras of Rorasg/Rorasg with wild-type using cellular markers for Purkinje cells and granule cells has shown that the Rorasg effect is intrinsic to the Purkinje cells and that granule cells are affected secondarily (J:28093, J:11945). Purkinje cells are probably defective as early as postnatal day 4 (J:6875). The granule cell deficiency may result from failure of Purkinje cells to adequately stimulate granule cell genesis (J:28092), as well as from later cell death due to failure of synapsis with Purkinje cells. Staggerer mice have been used as a source of an agranulate cerebellum in a number of investigations of the composition and function of granule cells.Other effects of Rorasg include persistence of multipleinnervation of Purkinje cells by climbing fibers (J:6260), reduction in size of deep cerebellar nuclei (J:6554) and inferior olivary complex (J:7948), and abnormal patterns of ganglioside composition and enzymatic activity (J:7910). Inferior olivary neuron numbers and definition of the olivary subnuclei are normal at birth but decline thereafter (J:20982). Death of inferior olivary neurons, like that of granule cells, is apparently an indirect effect of the Rorasg gene, caused by the lack of Purkinje cells with which to synapse (J:28468).Cerebellar cells of Rorasg/Rorasg mice at 7 days postnatal have immature cell surface components of a type which are present in +/+ cells at late prenatal and neonatal stages (J:6068, J:6088). In particular, the conversion of neural cell adhesion molecules (NCAM) from embryonic to adult form which is normally complete by 21 days does not occur in Rorasg/Rorasg mice (J:6930).Purkinje cells are the predominant siteof expression of calmodulin in the cerebellum of normal mice, but Rorasg/Rorasg mice do not produce any mRNA for the Calm1 locus in these cells (J:28469).Peripheral macrophages of staggerer mice, and those of several other cerebellar mutant mice, show greatly increased production of interleukin 1 beta (J:28095). Since Il1a and Tnf are also hyperexpressed in staggerer macrophages, the increases represent a general condition of hyperexcitability of these cells (J:1431). Il6 hyperexpression was also found in Rorasg/Rorasg mice but not in Grid2/+ animals (J:11652), although the latter did show hyperexpression of Il1a, Il1b, and Tnf (J:2228). Matsui et al. (J:28478) report elevated levels of somatostatin in brainsof several ataxic mouse mutants, including Rorasg homozygotes. The concentration of thyrotropin releasing hormone (TH) is also elevated in brains of these mutants (J:28467), and administration of a TRH analog, YM-14673, ameliorated the ataxia,suggesting that excess TRH may have an ataxic effect (J:18435).The reproductive life of Rorasg/Rorasg female mice is curtailed by late sexual maturation, irregular estrous cycling, and a shortened post-puberal period of reproduction (J:1960). Neonatal vestibular stimulation by rotation on a tilted plain improved gait and body balance in Rorasg/Rorasg mice and also led to improved mating efficiency (J:14535), suggesting that mating defects in these mice may bea secondary effect of the gait and balance difficulties. Long-term selection for ability to reproduce improved the maternal behavior of homozygous staggerer females without abolishing gait and balance difficulties, suggesting that Rorasg effects on reproduction are not entirely due to these difficulties (J:28416).Male staggerer mice are able to differentiate between pheromones secreted by estrous and anestrous females (J:15645). Some male Rorasg/Rorasg mice suffer from a penile disability, the penis in erection being directed rearward. The disability is intermittent even in those males subject to it, and is of little importance in determining male mating deficiency (J:32193).Although Rorasg/+ heterozygotes are behaviorally normal with normal cerebellar cytoarchitecture and composition, these heterozygotes suffer accelerated loss of Purkinje cells, granule cells, and inferior olivary neurons with age (J:1431).Rorasg/Rorasg homozygotesusually die during the fourth week of life. Some survive to adulthood, and one male has bred (J:13140).
Molecular Note This allele contains a 6.5kb genomic deletion of an exon encoding part of the ligand binding domain. The deletion results in an exon-skipping event that introduces a shift in the reading frame. The resulting protein is predicted to be truncated due to introduction of a premature stop codon. [MGI Ref ID J:31470]

Genotyping

Genotyping Information

Genotyping Protocols

Rorasg, HRM, vers. 2
Rorasg, STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Mamontova A; Seguret-Mace S; Esposito B; Chaniale C; Bouly M; Delhaye-Bouchaud N; Luc G; Staels B; Duverger N; Mariani J; Tedgui A. 1998. Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORalpha. Circulation 98(24):2738-43. [PubMed: 9851961]  [MGI Ref ID J:52105]

SIDMAN RL; LANE PW; DICKIE MM. 1962. Staggerer, a new mutation in the mouse affecting the cerebellum. Science 137:610-2. [PubMed: 13912552]  [MGI Ref ID J:13140]

Additional References

Hamilton BA; Frankel WN; Kerrebrock AW; Hawkins TL; FitzHugh W; Kusumi K; Russell LB; Mueller KL; van Berkel V; Birren BW; Kruglyak L; Lander ES. 1996. Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Nature 379(6567):736-9. [PubMed: 8602221]  [MGI Ref ID J:31470]

Heuze P; Feron C; Baudoin C. 1997. Early behavioral development of mice is affected by staggerer mutation as soon as postnatal day three. Brain Res Dev Brain Res 101(1-2):81-4. [PubMed: 9263582]  [MGI Ref ID J:42144]

Kopmels B; Wollman EE; Guastavino JM; Delhaye-Bouchaud N; Fradelizi D; Mariani J. 1990. Interleukin-1 hyperproduction by in vitro activated peripheral macrophages from cerebellar mutant mice. J Neurochem 55(6):1980-5. [PubMed: 2230805]  [MGI Ref ID J:28095]

Perandones C; Costanzo RV; Kowaljow V; Pivetta OH; Carminatti H; Radrizzani M. 2004. Correlation between synaptogenesis and the PTEN phosphatase expression in dendrites during postnatal brain development. Brain Res Mol Brain Res 128(1):8-19. [PubMed: 15337313]  [MGI Ref ID J:92848]

Yoon CH. 1972. Developmental mechanism for changes in cerebellum of staggerer mouse, a neurological mutant of genetic origin. Neurology 22(7):743-54. [PubMed: 4673255]  [MGI Ref ID J:5304]

Zanjani HS; Mariani J; Delhaye-Bouchaud N; Herrup K. 1992. Neuronal cell loss in heterozygous staggerer mutant mice: a model for genetic contributions to the aging process. Brain Res Dev Brain Res 67(2):153-60. [PubMed: 1511513]  [MGI Ref ID J:1431]

Rorasg related

Bahjaoui-Bouhaddi M; Padilla F; Nicolet M; Cifuentes-Diaz C; Fellmann D; Mege RM. 1997. Localized deposition of M-cadherin in the glomeruli of the granular layer during the postnatal development of mouse cerebellum. (Erratum 1997;382:139) J Comp Neurol 378(2):180-95. [PubMed: 9120059]  [MGI Ref ID J:38641]

Bakalian A; Kopmels B; Messer A; Fradelizi D; Delhaye-Bouchaud N; Wollman E; Mariani J. 1992. Peripheral macrophage abnormalities in mutant mice with spinocerebellar degeneration. Res Immunol 143(1):129-39. [PubMed: 1565842]  [MGI Ref ID J:2228]

Baurle J; Hoshi M; Grusser-Cornehls U. 1998. Dependence of parvalbumin expression on Purkinje cell input in the deep cerebellar nuclei. J Comp Neurol 392(4):499-514. [PubMed: 9514513]  [MGI Ref ID J:118391]

Bensoula AN; Guastavino JM; Lalonde R; Portet R; Bertin R; Krafft B. 1995. Spatial navigation of staggerer and normal mice during juvenile and adult stages. Physiol Behav 58(5):823-5. [PubMed: 8577876]  [MGI Ref ID J:30012]

Berrebi AS; Morgan JI; Mugnaini E. 1990. The Purkinje cell class may extend beyond the cerebellum. J Neurocytol 19(5):643-54. [PubMed: 2077109]  [MGI Ref ID J:121314]

Besnard S; Bakouche J; Lemaigre-Dubreuil Y; Mariani J; Tedgui A; Henrion D. 2002. Smooth muscle dysfunction in resistance arteries of the staggerer mouse, a mutant of the nuclear receptor RORalpha. Circ Res 90(7):820-5. [PubMed: 11964376]  [MGI Ref ID J:109735]

Besnard S; Silvestre JS; Duriez M; Bakouche J; Lemaigre-Dubreuil Y; Mariani J; Levy BI; Tedgui A. 2001. Increased ischemia-induced angiogenesis in the staggerer mouse, a mutant of the nuclear receptor Roralpha. Circ Res 89(12):1209-15. [PubMed: 11739287]  [MGI Ref ID J:115425]

Blatt GJ; Eisenman LM. 1985. A qualitative and quantitative light microscopic study of the inferior olivary complex in the adult staggerer mutant mouse. J Neurogenet 2(1):51-66. [PubMed: 4020530]  [MGI Ref ID J:7948]

Boufares S; Guastavino JM; Larsson K. 1993. Restoration of staggerer mouse maternal behavior following long-term breeding selection. Physiol Behav 53(6):1151-5. [PubMed: 8346298]  [MGI Ref ID J:14497]

Brugg B; Dubreuil YL; Huber G; Wollman EE; Delhaye-Bouchaud N; Mariani J. 1995. Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain. Proc Natl Acad Sci U S A 92(7):3032. [PubMed: 7708769]  [MGI Ref ID J:24161]

Caston J; Chianale C; Mariani J. 2004. Spatial memory of heterozygous staggerer (Rora(+)/Rora(sg)) versus normal (Rora(+)/Rora(+)) mice during aging. Behav Genet 34(3):319-24. [PubMed: 14990870]  [MGI Ref ID J:101986]

Caston J; Delhaye-Bouchaud N; Mariani J. 1995. Motor behavior of heterozygous staggerer mutant (+/sg) versus normal (+/+) mice during aging. Behav Brain Res 72(1-2):97-102. [PubMed: 8788862]  [MGI Ref ID J:31409]

Caston J; Hilber P; Chianale C; Mariani J. 2003. Effect of training on motor abilities of heterozygous staggerer mutant (Rora(+)/Rora(sg)) mice during aging. Behav Brain Res 141(1):35-42. [PubMed: 12672557]  [MGI Ref ID J:96224]

Costanzo RV; Vila-Ortiz GJ; Perandones C; Carminatti H; Matilla A; Radrizzani M. 2006. Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis. Eur J Neurosci 23(2):309-24. [PubMed: 16420440]  [MGI Ref ID J:105399]

Crepel F; Delhaye-Bouchaud N; Guastavino JM; Sampaio I. 1980. Multiple innervation of cerebellar Purkinje cells by climbing fibres in staggerer mutant mouse. Nature 283(5746):483-4. [PubMed: 7352029]  [MGI Ref ID J:6260]

Deiss V; Baudoin C. 1997. Hyposmia for butanol and vanillin in mutant staggerer male mice. Physiol Behav 61(2):209-13. [PubMed: 9035249]  [MGI Ref ID J:39053]

Deiss V; Baudoin C. 1999. Olfactory learning abilities in staggerer mutant mice. C R Acad Sci III 322(6):467-71. [PubMed: 10457598]  [MGI Ref ID J:58061]

Deiss V; Dubois M; Lalonde R; Strazielle C. 2001. Cytochrome oxidase activity in the olfactory system of staggerer mutant mice. Brain Res 910(1-2):126-33. [PubMed: 11489262]  [MGI Ref ID J:71124]

Deiss V; Feron C; Baudoin C. 1999. Discrimination of olfactory sexual cues in staggerer mutant male mice. Physiol Behav 67(5):631-4. [PubMed: 10604831]  [MGI Ref ID J:96570]

Deiss V; Strazielle C; Lalonde R. 2000. Regional brain variations of cytochrome oxidase activity and motor co-ordination in staggerer mutant mice. Neuroscience 95(3):903-11. [PubMed: 10670457]  [MGI Ref ID J:111971]

Doulazmi M; Frederic F; Capone F; Becker-Andre M; Delhaye-Bouchaud N; Mariani J. 2001. A comparative study of Purkinje cells in two RORalpha gene mutant mice: staggerer and RORalpha(-/-). Brain Res Dev Brain Res 127(2):165-74. [PubMed: 11335003]  [MGI Ref ID J:69287]

Doulazmi M; Frederic F; Lemaigre-Dubreuil Y; Hadj-Sahraoui N ; Delhaye-Bouchaud N ; Mariani J. 1999. Cerebellar Purkinje cell loss during life span of the heterozygous staggerer mouse (Rora(+)/Rora(sg)) is gender-related. J Comp Neurol 411(2):267-73. [PubMed: 10404252]  [MGI Ref ID J:56379]

Edelman GM; Chuong CM. 1982. Embryonic to adult conversion of neural cell adhesion molecules in normal and staggerer mice. Proc Natl Acad Sci U S A 79(22):7036-40. [PubMed: 6960362]  [MGI Ref ID J:6930]

Feron C; Baudoin C. 1992. Reactions of Staggerer and Non-Mutant Male Mice to Female Urine and Vaginal Secretion Odors Behav Processes 27(3):165-70.  [MGI Ref ID J:3557]

Feron C; Baudoin C. 1993. Sexual experience and preferences for odors of estrous females in staggerer mutant male mice. Behav Neural Biol 60(3):280-1. [PubMed: 8297325]  [MGI Ref ID J:15645]

Feron C; Baudoin C. 1998. Social isolation induces preference for odours of oestrous females in sexually naive male staggerer mutant mice. Chem Senses 23(1):119-21. [PubMed: 9530977]  [MGI Ref ID J:46472]

Feron C; Baudoin C. 1995. Social isolation partially restores reproduction of male staggerer mutant mice. Physiol Behav 58(1):107-10. [PubMed: 7667406]  [MGI Ref ID J:26698]

Feron C; Baudoin C. 1992. [Reduced influence of penile disability on the mating capacity of male staggerer mice] Reprod Nutr Dev 32(5-6):409-13. [PubMed: 1292478]  [MGI Ref ID J:32193]

Frantz GD; Wuenschell CW; Messer A; Tobin AJ. 1996. Presence of calbindin D28K and GAD67 mRNAs in both orthotopic and ectopic Purkinje cells of staggerer mice suggests that staggerer acts after the onset of cytodifferentiation. J Neurosci Res 44(3):255-62. [PubMed: 8723764]  [MGI Ref ID J:32917]

Genoux A; Dehondt H; Helleboid-Chapman A; Duhem C; Hum DW; Martin G; Pennacchio LA; Staels B; Fruchart-Najib J; Fruchart JC. 2005. Transcriptional regulation of apolipoprotein A5 gene expression by the nuclear receptor RORalpha. Arterioscler Thromb Vasc Biol 25(6):1186-92. [PubMed: 15790933]  [MGI Ref ID J:114292]

Giguere V; Beatty B; Squire J; Copeland NG; Jenkins NA. 1995. The orphan nuclear receptor ROR alpha (RORA) maps to a conserved region of homology on human chromosome 15q21-q22 and mouse chromosome 9. Genomics 28(3):596-8. [PubMed: 7490103]  [MGI Ref ID J:28416]

Gold DA; Baek SH; Schork NJ; Rose DW; Larsen DD; Sachs BD; Rosenfeld MG; Hamilton BA. 2003. RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron 40(6):1119-31. [PubMed: 14687547]  [MGI Ref ID J:87181]

Gold DA; Gent PM; Hamilton BA. 2007. ROR alpha in genetic control of cerebellum development: 50 staggering years. Brain Res 1140:19-25. [PubMed: 16427031]  [MGI Ref ID J:120622]

Grunwald GB; Eisenman LM. 1993. Analysis of protein variations in adult and postnatal day 11 staggerer and lurcher mutant mice. Brain Res Dev Brain Res 73(1):146-50. [PubMed: 8513552]  [MGI Ref ID J:11841]

Guastavino JM; Larsson K. 1992. The staggerer gene curtails the reproductive life span of females. Behav Genet 22(1):101-12. [PubMed: 1590727]  [MGI Ref ID J:1960]

Guastavino JM; Larsson K; Allain C; Jaisson P. 1993. Neonatal vestibular stimulation and mating in cerebellar mutants. Behav Genet 23(3):265-9. [PubMed: 8352721]  [MGI Ref ID J:14535]

Guo H; Sekiguchi M; Tanaka O; Inoue T; Shima H; Nagao M; Tamura S; Abe H. 1995. Protein phosphatase mRNA expression in Purkinje cells of staggerer and reeler mutant mice. Brain Res Mol Brain Res 33(1):121-6. [PubMed: 8774953]  [MGI Ref ID J:28842]

Hadj-Sahraoui N; Frederic F; Zanjani H; Delhaye-Bouchaud N; Herrup K; Mariani J. 2001. Progressive atrophy of cerebellar Purkinje cell dendrites during aging of the heterozygous staggerer mouse (Rora(+/sg)). Brain Res Dev Brain Res 126(2):201-9. [PubMed: 11248354]  [MGI Ref ID J:68149]

Hadj-Sahraoui N; Frederic F; Zanjani H; Herrup K; Delhaye-Bouchaud N ; Mariani J. 1997. Purkinje cell loss in heterozygous staggerer mutant mice during aging. Brain Res Dev Brain Res 98(1):1-8. [PubMed: 9027398]  [MGI Ref ID J:37701]

Hamilton BA; Frankel WN; Kerrebrock AW; Hawkins TL; FitzHugh W; Kusumi K; Russell LB; Mueller KL; van Berkel V; Birren BW; Kruglyak L; Lander ES. 1996. Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Nature 379(6567):736-9. [PubMed: 8602221]  [MGI Ref ID J:31470]

Hatten ME; Messer A. 1978. Postnatal cerebellar cells from staggerer mutant mice express embryonic cell surface characteristic. Nature 276(5687):504-6. [PubMed: 723931]  [MGI Ref ID J:6068]

Herrup K. 1983. Role of staggerer gene in determining cell number in cerebellar cortex. I. Granule cell death is an indirect consequence of staggerer gene action. Brain Res 313(2):267-74. [PubMed: 6667376]  [MGI Ref ID J:28093]

Herrup K; Mullen RJ. 1979. Regional variation and absence of large neurons in the cerebellum of the staggerer mouse. Brain Res 172(1):1-12. [PubMed: 466453]  [MGI Ref ID J:6185]

Herrup K; Mullen RJ. 1979. Staggerer chimeras: intrinsic nature of Purkinje cell defects and implications for normal cerebellar development. Brain Res 178(2-3):443-57. [PubMed: 509213]  [MGI Ref ID J:11945]

Heuze P; Feron C; Baudoin C. 1997. Early behavioral development of mice is affected by staggerer mutation as soon as postnatal day three. Brain Res Dev Brain Res 101(1-2):81-4. [PubMed: 9263582]  [MGI Ref ID J:42144]

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Nurieva RI; Chung Y; Hwang D; Yang XO; Kang HS; Ma L; Wang YH; Watowich SS; Jetten AM; Tian Q; Dong C. 2008. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29(1):138-49. [PubMed: 18599325]  [MGI Ref ID J:137869]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB29

Colony Maintenance

Breeding & HusbandryRorasg/Rorasgmice can be identified by 10-15 days of age by their poor locomotor coordination, lurching movements and frequent falls; homozygotes as young as three days can be distinguished by behavioral testing (Heuze et al.1997). Homozygotes die between two to three weeks of age. Due to their early and high mortality, homozygous mutant mice are not available from our colony. In some cases, the homozygote lifespan can be extended by adding crushed grain to the bottom of the cage and keeping pups with a lactating female. As heterozygotes are indistinguishable phenotypically from wild type mice, they must be identified by a PCR based genotyping assay.
Mating SystemHeterozygote x Heterozygote         (Female x Male)
PCR typed heterozygote x heterozygote
Diet Information LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice (US dollars $)GenderGenotypes Provided
Individual Mouse Price $203.30Female or MaleHeterozygous for Rorasg
Pairs /Price (US dollars $)Pair Genotype
$406.60Heterozygous for Rorasg x Heterozygous for Rorasg

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice (US dollars $)GenderGenotypes Provided
Individual Mouse Price $264.30Female or MaleHeterozygous for Rorasg
Pairs /Price (US dollars $)Pair Genotype
$528.60Heterozygous for Rorasg x Heterozygous for Rorasg

Additional Supply Details

Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes

Control Information

  Control
   Typed heterozygote from the colony
   Wild-type from the colony
   Wild type mice from the colony are the preferred controls. Untyped mice from the colony may be used; however, heterozygotes exhibit "accelerated loss of Purkinje cells, granule cells, and inferior olivary neurons with age" (MLC; Zanjani et al.1992; Hadj-Sahraoui et al.1997).
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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