Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Stock; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse   Donating Investigator Tak Mak,   University Health Network/Un of Toronto

Appearance
black
Related Genotype: a/a

Description
Mice homozygous for both the Cd4^tm1Mak and Cd8a^tm1Mak targeted mutations have a significant block in both CD4⁺ and CD8⁺ T-cell development. Homozygous mutant mice also show a Class II restricted deficit in helper T-cell activity and other T-cell responses.

Control Information

	Control
	101045 B6129SF2/J	(approximate)
Considerations for Choosing Controls

Related Strains

Strains carrying   Cd4^tm1Mak allele

002663	B6.129S2-Cd4tm1Mak/J
006483	CBy.129S2(B6)-Cd4tm1Mak/J

View Strains carrying   Cd4^tm1Mak     (2 strains)

Strains carrying   Cd8a^tm1Mak allele

002665	B6.129S2-Cd8atm1Mak/J
007071	CByJ.129S2(B6)-Cd8atm1Mak/J
005513	NOD.129S2(B6)-Cd8atm1Mak/DvsJ

View Strains carrying   Cd8a^tm1Mak     (3 strains)

Strains carrying other alleles of Cd4

002447	B10.129S2(B6)-Cd4tm1Litt/J
010514	B10.Cg-H2g Tg(Cd4-Klra1)6295Dl/J
002663	B6.129S2-Cd4tm1Mak/J
002269	B6.129S6-Cd4tm1Knw/J
002268	B6;129S6-Cd4tm1Knw/J
012895	C57BL/6-Tg(Cd4-Il17rb)5Cdon/J
014639	C57BL/6-Tg(Cd4-TcraDN32D3)1Aben/J
014644	C57BL/6-Tg(Cd4-Zbtb16)1797Aben/J
006483	CBy.129S2(B6)-Cd4tm1Mak/J
003090	NOD.129S6(B6)-Cd4tm1Knw/DvsJ
005328	NOD/ShiLt-Tg(Cd4-DsRed)4Lt/J

View Strains carrying other alleles of Cd4     (11 strains)

Strains carrying other alleles of Cd8a

017562	B6(Cg)-Cd8atm1.1(cre)Koni/J
002665	B6.129S2-Cd8atm1Mak/J
000407	B6.PL-Cd8aa Cd8b1a/(75NS)CyJ
001065	B6.PL-Cd8aa Cd8b1a/(85NS)CyJ
008766	C57BL/6-Tg(Cd8a-cre)1Itan/J
007071	CByJ.129S2(B6)-Cd8atm1Mak/J
005513	NOD.129S2(B6)-Cd8atm1Mak/DvsJ

View Strains carrying other alleles of Cd8a     (7 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

Cd4^tm1Mak/Cd4^tm1Mak Cd8a^tm1Mak/Cd8a^tm1Mak

        involves: 129S2/SvPas * C57BL/6 * DBA/2

• immune system phenotype
• abnormal T cell differentiation
  • there is a 5-fold drop in the number of mature alphabeta TCR⁺ HAS^- T cells in the thymus   (MGI Ref ID J:12572)
  • alphabeta TCR expression on these mature double negative cells is lower than in mature T cells of wild-type mice   (MGI Ref ID J:12572)
  • despite lack of CD4 and CD8 expression, alphabeta T cells are still present in the periphery   (MGI Ref ID J:12572)
• • abnormal double-negative T cell morphology
    • "mature" double negative thymocytes are found that are alphabeta TCR⁺ HAS^-   (MGI Ref ID J:12572)
  • decreased double-positive T cell number
    • double positive T cells are absent   (MGI Ref ID J:12572)
• abnormal T cell number
  • the alphabeta T cell number in lymph nodes varies from 5% to 50% of normal   (MGI Ref ID J:12572)
• • abnormal gamma-delta T cell number
    • the absolute number of gammadelta T cells is decreased though the relative percentage of lymph node is increased from 1% to 3%   (MGI Ref ID J:12572)
  • decreased double-positive T cell number
    • double positive T cells are absent   (MGI Ref ID J:12572)
• abnormal thymus medulla morphology
  • the medulla is reduced in size   (MGI Ref ID J:12572)
• defective cytotoxic T cell cytolysis
  • LCMV-specific class I MHC-restricted cytotoxic T cell responses are not activated in these mice   (MGI Ref ID J:12572)
  • alloantigen specific lysis of target cells by T cells in mixed lymphocyte culture is reduced   (MGI Ref ID J:12572)
  • the lysis of cells is specific for class I MHC antigens   (MGI Ref ID J:12572)
• increased length of allograft survival
  • tail skin graphs from donor mice of the same MHC haplotypes are not rejected within a three month period compared to controls that have no graph survival after 18 days   (MGI Ref ID J:12572)
  • when donor mice have a different MHC haplotype, skin graft rejection is similar to controls   (MGI Ref ID J:12572)
• hematopoietic system phenotype
• abnormal T cell differentiation
  • there is a 5-fold drop in the number of mature alphabeta TCR⁺ HAS^- T cells in the thymus   (MGI Ref ID J:12572)
  • alphabeta TCR expression on these mature double negative cells is lower than in mature T cells of wild-type mice   (MGI Ref ID J:12572)
  • despite lack of CD4 and CD8 expression, alphabeta T cells are still present in the periphery   (MGI Ref ID J:12572)
• • abnormal double-negative T cell morphology
    • "mature" double negative thymocytes are found that are alphabeta TCR⁺ HAS^-   (MGI Ref ID J:12572)
  • decreased double-positive T cell number
    • double positive T cells are absent   (MGI Ref ID J:12572)
• abnormal T cell number
  • the alphabeta T cell number in lymph nodes varies from 5% to 50% of normal   (MGI Ref ID J:12572)
• • abnormal gamma-delta T cell number
    • the absolute number of gammadelta T cells is decreased though the relative percentage of lymph node is increased from 1% to 3%   (MGI Ref ID J:12572)
  • decreased double-positive T cell number
    • double positive T cells are absent   (MGI Ref ID J:12572)
• abnormal thymus medulla morphology
  • the medulla is reduced in size   (MGI Ref ID J:12572)
• cellular phenotype
• abnormal T cell differentiation
  • there is a 5-fold drop in the number of mature alphabeta TCR⁺ HAS^- T cells in the thymus   (MGI Ref ID J:12572)
  • alphabeta TCR expression on these mature double negative cells is lower than in mature T cells of wild-type mice   (MGI Ref ID J:12572)
  • despite lack of CD4 and CD8 expression, alphabeta T cells are still present in the periphery   (MGI Ref ID J:12572)
• • abnormal double-negative T cell morphology
    • "mature" double negative thymocytes are found that are alphabeta TCR⁺ HAS^-   (MGI Ref ID J:12572)
  • decreased double-positive T cell number
    • double positive T cells are absent   (MGI Ref ID J:12572)

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

Cd4^tm1Mak/Cd4^tm1Mak Cd8a^tm1Mak/Cd8a^tm1Mak

        involves: 129S2/SvPas

• immune system phenotype
• increased susceptibility to viral infection
  • virus is still detectable in bone marrow, heart, and other organs 1 month after polyomavirus infection compared to controls that clear the infection by one month   (MGI Ref ID J:110749)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Cd4^tm1Mak related

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Cd8a^tm1Mak related

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Cd4tm1Mak
Allele Name		targeted mutation 1, Tak Mak
Allele Type		Targeted (knock-out)
Common Name(s)		CD4 KO; CD4-; CD40;
Mutation Made By		Tak Mak,   University Health Network/Un of Toronto
Strain of Origin		129S2/SvPas
ES Cell Line Name		D3
ES Cell Line Strain		129S2/SvPas
Gene Symbol and Name		Cd4, CD4 antigen
Chromosome		6
Gene Common Name(s)		CD4mut; L3T4; Ly-4; W3/25; lymphocyte antigen 4; p55;
Molecular Note		A neomycin resistance cassette was inserted into exon 5. Flow cytometry analysis demonstrated that the protein was absent from the cell surface of thymocytes and lymph node cells in homozygous mice. [MGI Ref ID J:68957]
Allele Symbol		Cd8atm1Mak
Allele Name		targeted mutation 1, Tak Mak
Allele Type		Targeted (knock-out)
Common Name(s)		CD8 KO; CD8-; CD8-KO; CD8KO; CD8alpha-; CD8alpha-; Cd8atm1Mak; Lyt-2-;
Mutation Made By		Tak Mak,   University Health Network/Un of Toronto
Strain of Origin		129S2/SvPas
ES Cell Line Name		D3
ES Cell Line Strain		129S2/SvPas
Gene Symbol and Name		Cd8a, CD8 antigen, alpha chain
Chromosome		6
Gene Common Name(s)		BB154331; CD8; Leu2; Ly-2; Ly-35; Ly-B; Lyt-2; MAL; T-lymphocyte antigen 2; expressed sequence BB154331; lymphocyte antigen 2; lymphocyte antigen 35; p32;
Molecular Note		A neomycin resistance gene was inserted into exon 1. Flow cytometry analysis on thymus and lymph node cells derived from homozygous mice confirmed that no detectable encoded protein was expressed on the cell surface. [MGI Ref ID J:68956] [MGI Ref ID J:82297]

Genotyping

Genotyping Information

Genotyping Protocols

Cd8a^tm1Mak, Melt Curve Analysis
Cd8a^tm1Mak, Standard PCR
Generic Cd4, Standard PCR

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Mak TW; Rahemtulla A; Schilham M; Koh DR; Fung-Leung WP. 1992. Generation of mutant mice lacking surface expression of CD4 or CD8 by gene targeting. J Autoimmun 5 Suppl A:55-9. [PubMed: 1503636]  [MGI Ref ID J:575]

Additional References

Fung-Leung WP; Schilham MW; Rahemtulla A; Kundig TM; Vollenweider M; Potter J; van Ewijk W; Mak TW. 1991. CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell 65(3):443-9. [PubMed: 1673361]  [MGI Ref ID J:68956]

Rahemtulla A; Fung-Leung WP; Schilham MW; Kundig TM; Sambhara SR; Narendran A; Arabian A; Wakeham A; Paige CJ; Zinkernagel RM; et al.. 1991. Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4. Nature 353(6340):180-4. [PubMed: 1832488]  [MGI Ref ID J:68957]

Schilham MW; Fung-Leung WP; Rahemtulla A; Kuendig T; Zhang L; Potter J; Miller RG; Hengartner H; Mak TW. 1993. Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8. Eur J Immunol 23(6):1299-304. [PubMed: 8500525]  [MGI Ref ID J:12572]

Cd4^tm1Mak related

Adoro S; Erman B; Sarafova SD; Van Laethem F; Park JH; Feigenbaum L; Singer A. 2008. Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic. J Immunol 181(10):6975-83. [PubMed: 18981117]  [MGI Ref ID J:140942]

Antony PA; Piccirillo CA; Akpinarli A; Finkelstein SE; Speiss PJ; Surman DR; Palmer DC; Chan CC; Klebanoff CA; Overwijk WW; Rosenberg SA; Restifo NP. 2005. CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells. J Immunol 174(5):2591-601. [PubMed: 15728465]  [MGI Ref ID J:129825]

Bachmaier K; Neu N; Yeung RS; Mak TW; Liu P; Penninger JM. 1999. Generation of humanized mice susceptible to peptide-induced inflammatory heart disease. Circulation 99(14):1885-91. [PubMed: 10199887]  [MGI Ref ID J:129115]

Battegay M; Moskophidis D; Rahemtulla A; Hengartner H; Mak TW; Zinkernagel RM. 1994. Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice. J Virol 68(7):4700-4. [PubMed: 7911534]  [MGI Ref ID J:18756]

Bayer AL; Chirinos J; Cabello C; Yang J; Matsutani T; Malek TR; Levy RB. 2011. Expansion of a restricted residual host T reg-cell repertoire is dependent on IL-2 following experimental autologous hematopoietic stem transplantation. Eur J Immunol 41(12):3467-78. [PubMed: 21928285]  [MGI Ref ID J:179509]

Berke Z; Wen T; Jin S; Klein G; Dalianis T. 1995. Polyomavirus persists in CD4/8 double-knockout, but not in CD4 or CD8 single-knockout mice. Virology 212(1):268-71. [PubMed: 7676644]  [MGI Ref ID J:110749]

Berke Z; Wen T; Klein G; Dalianis T. 1996. Polyoma tumor development in neonatally polyoma-virus-infected CD4-/- and CD8-/- single knockout and CD4-/-8-/- double knockout mice. Int J Cancer 67(3):405-8. [PubMed: 8707416]  [MGI Ref ID J:113042]

Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. [PubMed: 15153508]  [MGI Ref ID J:90518]

Bitsaktsis C; Nandi B; Racine R; MacNamara KC; Winslow G. 2007. T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection. Infect Immun 75(10):4933-41. [PubMed: 17664264]  [MGI Ref ID J:125283]

Black KE; Murray JA; David CS. 2002. HLA-DQ Determines the Response to Exogenous Wheat Proteins: A Model of Gluten Sensitivity in Transgenic Knockout Mice. J Immunol 169(10):5595-600. [PubMed: 12421937]  [MGI Ref ID J:80059]

Blazar BR; Lees CJ; Martin PJ; Noelle RJ; Kwon B; Murphy W; Taylor PA. 2000. Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions. J Immunol 165(9):4901-9. [PubMed: 11046015]  [MGI Ref ID J:118027]

Boenisch O; D'Addio F; Watanabe T; Elyaman W; Magee CN; Yeung MY; Padera RF; Rodig SJ; Murayama T; Tanaka K; Yuan X; Ueno T; Jurisch A; Mfarrej B; Akiba H; Yagita H; Najafian N. 2010. TIM-3: a novel regulatory molecule of alloimmune activation. J Immunol 185(10):5806-19. [PubMed: 20956339]  [MGI Ref ID J:165781]

Borenstein SH; Graham J; Zhang XL; Chamberlain JW. 2000. CD8+ T cells are necessary for recognition of allelic, but not locus-mismatched or xeno-, HLA class I transplantation antigens. J Immunol 165(5):2341-53. [PubMed: 10946256]  [MGI Ref ID J:80678]

Burne MJ; Daniels F; El Ghandour A; Mauiyyedi S; Colvin RB; O'Donnell MP; Rabb H. 2001. Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure. J Clin Invest 108(9):1283-90. [PubMed: 11696572]  [MGI Ref ID J:118005]

Caldwell CC; Okaya T; Martignoni A; Husted T; Schuster R; Lentsch AB. 2005. Divergent functions of CD4+ T lymphocytes in acute liver inflammation and injury after ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol 289(5):G969-76. [PubMed: 16002566]  [MGI Ref ID J:104787]

Chan K; Lee DJ; Schubert A; Tang CM; Crain B; Schoenberger SP; Corr M. 2001. The roles of MHC class II, CD40, and B7 costimulation in CTL induction by plasmid DNA. J Immunol 166(5):3061-6. [PubMed: 11207256]  [MGI Ref ID J:126695]

Chan WC; Duong TT; Yeung RS. 2004. Presence of IFN-gamma does not indicate its necessity for induction of coronary arteritis in an animal model of Kawasaki disease. J Immunol 173(5):3492-503. [PubMed: 15322214]  [MGI Ref ID J:92708]

Chapoval SP; Iijima K; Marietta EV; Smart MK; Chapoval AI; Andrews AG; David CS. 2002. Allergic inflammatory response to short ragweed allergenic extract in HLA-DQ transgenic mice lacking CD4 gene. J Immunol 168(2):890-9. [PubMed: 11777987]  [MGI Ref ID J:73744]

Chapoval SP; Marietta EV; Smart MK; David CS. 2001. Requirements for allergen-induced airway inflammation and hyperreactivity in CD4-deficient and CD4-sufficient HLA-DQ transgenic mice. J Allergy Clin Immunol 108(5):764-71. [PubMed: 11692102]  [MGI Ref ID J:106479]

Chen SY; Takeoka Y; Ansari AA; Boyd R; Klinman DM; Gershwin ME. 1996. The natural history of disease expression in CD4 and CD8 gene-deleted New Zealand black (NZB) mice. J Immunol 157(6):2676-84. [PubMed: 8805673]  [MGI Ref ID J:35433]

Chen Z; Yu S; Concha HQ; Zhu Y; Mix E; Winblad B; Ljunggren HG; Zhu J. 2004. Kainic acid-induced excitotoxic hippocampal neurodegeneration in C57BL/6 mice: B cell and T cell subsets may contribute differently to the pathogenesis. Brain Behav Immun 18(2):175-85. [PubMed: 14759595]  [MGI Ref ID J:105331]

Chiang EY; Stroynowski I. 2004. A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor. J Immunol 173(7):4394-401. [PubMed: 15383569]  [MGI Ref ID J:93729]

Choo DK; Murali-Krishna K; Anita R; Ahmed R. 2010. Homeostatic turnover of virus-specific memory CD8 T cells occurs stochastically and is independent of CD4 T cell help. J Immunol 185(6):3436-44. [PubMed: 20733203]  [MGI Ref ID J:163530]

Choudhury A; Cohen PL; Eisenberg RA. 2010. B cells require 'nurturing' by CD4 T cells during development in order to respond in chronic graft-versus-host model of systemic lupus erythematosus. Clin Immunol :. [PubMed: 20381429]  [MGI Ref ID J:160847]

Choudhury A; Maldonado MA; Cohen PL; Eisenberg RA. 2005. The role of host CD4 T cells in the pathogenesis of the chronic graft-versus-host model of systemic lupus erythematosus. J Immunol 174(12):7600-9. [PubMed: 15944260]  [MGI Ref ID J:100787]

Daniel D; Meyer-Morse N; Bergsland EK; Dehne K; Coussens LM; Hanahan D. 2003. Immune Enhancement of Skin Carcinogenesis by CD4+ T Cells. J Exp Med 197(8):1017-28. [PubMed: 12695493]  [MGI Ref ID J:82978]

Dautigny N; Le Campion A; Lucas B. 1999. Timing and casting for actors of thymic negative selection. J Immunol 162(3):1294-302. [PubMed: 9973382]  [MGI Ref ID J:124433]

DeNardo DG; Barreto JB; Andreu P; Vasquez L; Tawfik D; Kolhatkar N; Coussens LM. 2009. CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 16(2):91-102. [PubMed: 19647220]  [MGI Ref ID J:151976]

Derrick SC; Evering TH; Sambandamurthy VK; Jalapathy KV; Hsu T; Chen B; Chen M; Russell RG; Junqueira-Kipnis AP; Orme IM; Porcelli SA; Jacobs WR Jr; Morris SL. 2007. Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine. Immunology 120(2):192-206. [PubMed: 17076705]  [MGI Ref ID J:122314]

Dispirito JR; Shen H. 2010. Histone acetylation at the single-cell level: a marker of memory CD8(+) T cell differentiation and functionality. J Immunol 184(9):4631-6. [PubMed: 20308634]  [MGI Ref ID J:160485]

Duong TT; Silverman ED; Bissessar MV; Yeung RS. 2003. Superantigenic activity is responsible for induction of coronary arteritis in mice: an animal model of Kawasaki disease. Int Immunol 15(1):79-89. [PubMed: 12502728]  [MGI Ref ID J:81746]

Ehinger M; Vestberg M; Johansson AC; Johannesson M; Svensson A; Holmdahl R. 2001. Influence of CD4 or CD8 deficiency on collagen-induced arthritis. Immunology 103(3):291-300. [PubMed: 11454058]  [MGI Ref ID J:110421]

Fenster CP; Chisnell HK; Fry CR; Fenster SD. 2010. The role of CD4-dependent signaling in interleukin-16 induced c-Fos expression and facilitation of neurite outgrowth in cerebellar granule neurons. Neurosci Lett 485(3):212-6. [PubMed: 20849916]  [MGI Ref ID J:167253]

Fischbein MP; Ardehali A; Yun J; Schoenberger S; Laks H; Irie Y; Dempsey P; Cheng G; Fishbein MC; Bonavida B. 2000. CD40 signaling replaces CD4+ lymphocytes and its blocking prevents chronic rejection of heart transplants. J Immunol 165(12):7316-22. [PubMed: 11120867]  [MGI Ref ID J:118395]

Flano E; Woodland DL; Blackman MA. 1999. Requirement for CD4+ T cells in V beta 4+CD8+ T cell activation associated with latent murine gammaherpesvirus infection. J Immunol 163(6):3403-8. [PubMed: 10477611]  [MGI Ref ID J:119171]

Freland S; Ljunggren H. 2000. beta2-Microglobulin/CD8 -/- mice reveal significant role for CD8+ T cells in graft rejection responses in beta2-microglobulin -/- mice Scand J Immunol 51(3):219-23. [PubMed: 10736089]  [MGI Ref ID J:61231]

Fuller MJ; Khanolkar A; Tebo AE; Zajac AJ. 2004. Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections. J Immunol 172(7):4204-14. [PubMed: 15034033]  [MGI Ref ID J:88714]

Grayson MH; Cheung D; Rohlfing MM; Kitchens R; Spiegel DE; Tucker J; Battaile JT; Alevy Y; Yan L; Agapov E; Kim EY; Holtzman MJ. 2007. Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. J Exp Med 204(11):2759-69. [PubMed: 17954569]  [MGI Ref ID J:126124]

Grueter B; Petter M; Egawa T; Laule-Kilian K; Aldrian CJ; Wuerch A; Ludwig Y; Fukuyama H; Wardemann H; Waldschuetz R; Moroy T; Taniuchi I; Steimle V; Littman DR; Ehlers M. 2005. Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells. J Immunol 175(3):1694-705. [PubMed: 16034110]  [MGI Ref ID J:107280]

Guarda G; Dostert C; Staehli F; Cabalzar K; Castillo R; Tardivel A; Schneider P; Tschopp J. 2009. T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature 460(7252):269-73. [PubMed: 19494813]  [MGI Ref ID J:150357]

Heemskerk MH; Schilham MW; Schoemaker HM; Spierenburg G; Spaan WJ; Boog CJ. 1995. Activation of virus-specific major histocompatibility complex class II-restricted CD8+ cytotoxic T cells in CD4-deficient mice. Eur J Immunol 25(4):1109-12. [PubMed: 7737281]  [MGI Ref ID J:112983]

Hida S; Ogasawara K; Sato K; Abe M; Takayanagi H; Yokochi T; Sato T; Hirose S; Shirai T; Taki S; Taniguchi T. 2000. CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling Immunity 13(5):643-55. [PubMed: 11114377]  [MGI Ref ID J:66034]

Hornquist CE; Ekman L; Grdic KD; Schon K; Lycke NY. 1995. Paradoxical IgA immunity in CD4-deficient mice. Lack of cholera toxin-specific protective immunity despite normal gut mucosal IgA differentiation. J Immunol 155(6):2877-87. [PubMed: 7673704]  [MGI Ref ID J:110845]

Howe CL; Adelson JD; Rodriguez M. 2007. Absence of perforin expression confers axonal protection despite demyelination. Neurobiol Dis 25(2):354-9. [PubMed: 17112732]  [MGI Ref ID J:119009]

Huber SA; Sakkinen P; David C; Newell MK; Tracy RP. 2001. T helper-cell phenotype regulates atherosclerosis in mice under conditions of mild hypercholesterolemia. Circulation 103(21):2610-6. [PubMed: 11382732]  [MGI Ref ID J:133189]

Hung K; Hayashi R; Lafond-Walker A; Lowenstein C; Pardoll D; Levitsky H. 1998. The central role of CD4(+) T cells in the antitumor immune response. J Exp Med 188(12):2357-68. [PubMed: 9858522]  [MGI Ref ID J:51677]

Intlekofer AM; Takemoto N; Kao C; Banerjee A; Schambach F; Northrop JK; Shen H; Wherry EJ; Reiner SL. 2007. Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells. J Exp Med 204(9):2015-21. [PubMed: 17698591]  [MGI Ref ID J:126087]

Ip CW; Kroner A; Bendszus M; Leder C; Kobsar I; Fischer S; Wiendl H; Nave KA; Martini R. 2006. Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes. J Neurosci 26(31):8206-16. [PubMed: 16885234]  [MGI Ref ID J:111136]

Joetham A; Takeda K; Taube C; Miyahara N; Kanehiro A; Dakhama A; Gelfand EW. 2005. Airway hyperresponsiveness in the absence of CD4+ T cells after primary but not secondary challenge. Am J Respir Cell Mol Biol 33(1):89-96. [PubMed: 15845865]  [MGI Ref ID J:110969]

Kamperschroer C; Roberts DM; Zhang Y; Weng NP; Swain SL. 2008. SAP enables T cells to help B cells by a mechanism distinct from Th cell programming or CD40 ligand regulation. J Immunol 181(6):3994-4003. [PubMed: 18768854]  [MGI Ref ID J:139100]

Kang TW; Yevsa T; Woller N; Hoenicke L; Wuestefeld T; Dauch D; Hohmeyer A; Gereke M; Rudalska R; Potapova A; Iken M; Vucur M; Weiss S; Heikenwalder M; Khan S; Gil J; Bruder D; Manns M; Schirmacher P; Tacke F; Ott M; Luedde T; Longerich T; Kubicka S; Zender L. 2011. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 479(7374):547-51. [PubMed: 22080947]  [MGI Ref ID J:179823]

Khan IA; Schwartzman JD; Kasper LH; Moretto M. 1999. CD8+ CTLs are essential for protective immunity against Encephalitozoon cuniculi infection. J Immunol 162(10):6086-91. [PubMed: 10229850]  [MGI Ref ID J:120238]

Khanolkar A; Fuller MJ; Zajac AJ. 2004. CD4 T cell-dependent CD8 T cell maturation. J Immunol 172(5):2834-44. [PubMed: 14978084]  [MGI Ref ID J:88234]

Khiong K; Murakami M; Kitabayashi C; Ueda N; Sawa S; Sakamoto A; Kotzin BL; Rozzo SJ; Ishihara K; Verella-Garcia M; Kappler J; Marrack P; Hirano T. 2007. Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model. J Clin Invest 117(5):1270-81. [PubMed: 17476359]  [MGI Ref ID J:122142]

Kikuchi T; Andarini S; Xin H; Gomi K; Tokue Y; Saijo Y; Honjo T; Watanabe A; Nukiwa T. 2005. Involvement of fractalkine/CX3CL1 expression by dendritic cells in the enhancement of host immunity against Legionella pneumophila. Infect Immun 73(9):5350-7. [PubMed: 16113250]  [MGI Ref ID J:100418]

Kim DK; Tahara-Hanaoka S; Shinohara N; Nakauchi H. 2007. A human mutant CD4 molecule resistant to HIV-1 binding restores helper T-lymphocyte functions in murine CD4-deficient mice. Exp Mol Med 39(1):1-7. [PubMed: 17334223]  [MGI Ref ID J:134164]

Kim IS; Baek SH. 2010. Mouse models for breast cancer metastasis. Biochem Biophys Res Commun 394(3):443-7. [PubMed: 20230796]  [MGI Ref ID J:159230]

Kish DD; Li X; Fairchild RL. 2009. CD8 T cells producing IL-17 and IFN-gamma initiate the innate immune response required for responses to antigen skin challenge. J Immunol 182(10):5949-59. [PubMed: 19414746]  [MGI Ref ID J:148247]

Klein MA; Frigg R; Flechsig E; Raeber AJ; Kalinke U; Bluethmann H; Bootz F; Suter M; Zinkernagel RM; Aguzzi A. 1997. A crucial role for B cells in neuroinvasive scrapie [see comments] Nature 390(6661):687-90. [PubMed: 9414161]  [MGI Ref ID J:44933]

Koh DR; Ho A; Rahemtulla A; Fung-Leung WP; Griesser H; Mak TW. 1995. Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells. Eur J Immunol 25(9):2558-62. [PubMed: 7589126]  [MGI Ref ID J:28923]

Koh DR; Ho A; Rahemtulla A; Penninger J; Mak TW. 1994. Experimental allergic encephalomyelitis (EAE) in mice lacking CD4+ T cells. Eur J Immunol 24(9):2250-3. [PubMed: 7916298]  [MGI Ref ID J:112987]

Kohu K; Sato T; Ohno S; Hayashi K; Uchino R; Abe N; Nakazato M; Yoshida N; Kikuchi T; Iwakura Y; Inoue Y; Watanabe T; Habu S; Satake M. 2005. Overexpression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single-positive lineage. J Immunol 174(5):2627-36. [PubMed: 15728469]  [MGI Ref ID J:97715]

Kondo S; Beissert S; Wang B; Fujisawa H; Kooshesh F; Stratigos A; Granstein RD; Mak TW; Sauder DN. 1996. Hyporesponsiveness in contact hypersensitivity and irritant contact dermatitis in CD4 gene targeted mouse. J Invest Dermatol 106(5):993-1000. [PubMed: 8618064]  [MGI Ref ID J:32787]

Kontoyiannis D; Boulougouris G; Manoloukos M; Armaka M; Apostolaki M; Pizarro T; Kotlyarov A; Forster I; Flavell R; Gaestel M; Tsichlis P; Cominelli F; Kollias G. 2002. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med 196(12):1563-74. [PubMed: 12486099]  [MGI Ref ID J:108572]

Koya T; Matsuda H; Matsubara S; Miyahara N; Dakhama A; Takeda K; Gelfand EW. 2009. Differential effects of dendritic cell transfer on airway hyperresponsiveness and inflammation. Am J Respir Cell Mol Biol 41(3):271-80. [PubMed: 19151321]  [MGI Ref ID J:164635]

Kwong BY; Roberts SJ; Silberzahn T; Filler RB; Neustadter JH; Galan A; Reddy S; Lin WM; Ellis PD; Langford CF; Hayday AC; Girardi M. 2010. Molecular analysis of tumor-promoting CD8+ T cells in two-stage cutaneous chemical carcinogenesis. J Invest Dermatol 130(6):1726-36. [PubMed: 19924136]  [MGI Ref ID J:159950]

Law YM; Yeung RS; Mamalaki C; Kioussis D; Mak TW; Flavell RA. 1994. Human CD4 restores normal T cell development and function in mice deficient in murine CD4. J Exp Med 179(4):1233-42. [PubMed: 8145040]  [MGI Ref ID J:77270]

Lepisto AJ; Frank GM; Xu M; Stuart PM; Hendricks RL. 2006. CD8 T cells mediate transient herpes stromal keratitis in CD4-deficient mice. Invest Ophthalmol Vis Sci 47(8):3400-9. [PubMed: 16877409]  [MGI Ref ID J:112225]

Lesage S; Steff AM; Philippoussis F; Page M; Trop S; Mateo V ; Hugo P. 1997. CD4+ CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway. J Immunol 159(10):4762-71. [PubMed: 9366400]  [MGI Ref ID J:44075]

Lin X; Ma X; Rodriguez M; Roos RP. 2004. CD4+ T cells are important for clearance of DA strain of TMEV from the central nervous system of SJL/J mice. Int Immunol 16(9):1237-40. [PubMed: 15262897]  [MGI Ref ID J:91962]

Lin X; Pease LR; Murray PD; Rodriguez M. 1998. Theiler's virus infection of genetically susceptible mice induces central nervous system-infiltrating CTLs with no apparent viral or major myelin antigenic specificity. J Immunol 160(11):5661-8. [PubMed: 9605173]  [MGI Ref ID J:47789]

Liu M; Chien CC; Burne-Taney M; Molls RR; Racusen LC; Colvin RB; Rabb H. 2006. A pathophysiologic role for T lymphocytes in murine acute cisplatin nephrotoxicity. J Am Soc Nephrol 17(3):765-74. [PubMed: 16481417]  [MGI Ref ID J:135790]

Liu P; Aitken K; Kong YY; Opavsky MA; Martino T; Dawood F; Wen WH; Kozieradzki I; Bachmaier K; Straus D; Mak TW; Penninger JM. 2000. The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease. Nat Med 6(4):429-34. [PubMed: 10742150]  [MGI Ref ID J:119597]

Liu Y; Teige A; Mondoc E; Ibrahim S; Holmdahl R; Issazadeh-Navikas S. 2011. Endogenous collagen peptide activation of CD1d-restricted NKT cells ameliorates tissue-specific inflammation in mice. J Clin Invest 121(1):249-64. [PubMed: 21157037]  [MGI Ref ID J:171844]

Lucas PJ; Kim SJ; Mackall CL; Telford WG; Chu YW; Hakim FT; Gress RE. 2006. Dysregulation of IL-15-mediated T-cell homeostasis in TGF-beta dominant-negative receptor transgenic mice. Blood 108(8):2789-95. [PubMed: 16788095]  [MGI Ref ID J:139469]

Lunsford KE; Koester MA; Eiring AM; Horne PH; Gao D; Bumgardner GL. 2005. Targeting LFA-1 and cd154 suppresses the in vivo activation and development of cytolytic (cd4-Independent) CD8+ T cells. J Immunol 175(12):7855-66. [PubMed: 16339521]  [MGI Ref ID J:122220]

Lynch EA; Heijens CA; Horst NF; Center DM; Cruikshank WW. 2003. Cutting edge: IL-16/CD4 preferentially induces Th1 cell migration: requirement of CCR5. J Immunol 171(10):4965-8. [PubMed: 14607889]  [MGI Ref ID J:135472]

Mackerness KJ; Cox MA; Lilly LM; Weaver CT; Harrington LE; Zajac AJ. 2010. Pronounced Virus-Dependent Activation Drives Exhaustion but Sustains IFN-{gamma} Transcript Levels. J Immunol 185(6):3643-51. [PubMed: 20720198]  [MGI Ref ID J:163546]

Maeno T; Houghton AM; Quintero PA; Grumelli S; Owen CA; Shapiro SD. 2007. CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice. J Immunol 178(12):8090-6. [PubMed: 17548647]  [MGI Ref ID J:148578]

Matheson JM; Johnson VJ; Luster MI. 2005. Immune mediators in a murine model for occupational asthma: studies with toluene diisocyanate. Toxicol Sci 84(1):99-109. [PubMed: 15590890]  [MGI Ref ID J:106452]

McCausland MM; Yusuf I; Tran H; Ono N; Yanagi Y; Crotty S. 2007. SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase. J Immunol 178(2):817-28. [PubMed: 17202343]  [MGI Ref ID J:133047]

McCoy KD; Harris NL; Diener P; Hatak S; Odermatt B; Hangartner L; Senn BM; Marsland BJ; Geuking MB; Hengartner H; Macpherson AJ; Zinkernagel RM. 2006. Natural IgE production in the absence of MHC Class II cognate help. Immunity 24(3):329-39. [PubMed: 16546101]  [MGI Ref ID J:113324]

Mishra A; Schlotman J; Wang M; Rothenberg ME. 2007. Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in mice. J Leukoc Biol 81(4):916-24. [PubMed: 17194734]  [MGI Ref ID J:121455]

Mott KR; Underhill D; Wechsler SL; Ghiasi H. 2008. Lymphoid-related CD11c+ CD8alpha+ dendritic cells are involved in enhancing herpes simplex virus type 1 latency. J Virol 82(20):9870-9. [PubMed: 18667491]  [MGI Ref ID J:153404]

Murray PD; Pavelko KD; Leibowitz J; Lin X; Rodriguez M. 1998. CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis. J Virol 72(9):7320-9. [PubMed: 9696828]  [MGI Ref ID J:92227]

Newell KA; He G; Guo Z; Kim O; Szot GL; Rulifson I; Zhou P; Hart J; Thistlethwaite JR; Bluestone JA. 1999. Cutting edge: blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ but not CD8+ T cells. J Immunol 163(5):2358-62. [PubMed: 10452966]  [MGI Ref ID J:57103]

Ngai P; McCormick S; Small C; Zhang X; Zganiacz A; Aoki N; Xing Z. 2007. Gamma interferon responses of CD4 and CD8 T-cell subsets are quantitatively different and independent of each other during pulmonary Mycobacterium bovis BCG infection. Infect Immun 75(5):2244-52. [PubMed: 17307945]  [MGI Ref ID J:121875]

Northrop JK; Thomas RM; Wells AD; Shen H. 2006. Epigenetic remodeling of the IL-2 and IFN-gamma loci in memory CD8 T cells is influenced by CD4 T cells. J Immunol 177(2):1062-9. [PubMed: 16818762]  [MGI Ref ID J:134945]

Novy P; Quigley M; Huang X; Yang Y. 2007. CD4 T cells are required for CD8 T cell survival during both primary and memory recall responses. J Immunol 179(12):8243-51. [PubMed: 18056368]  [MGI Ref ID J:155035]

Olasz EB; Roh J; Yee CL; Arita K; Akiyama M; Shimizu H; Vogel JC; Yancey KB. 2007. Human bullous pemphigoid antigen 2 transgenic skin elicits specific IgG in wild-type mice. J Invest Dermatol 127(12):2807-17. [PubMed: 17657247]  [MGI Ref ID J:127328]

Oliveira-dos-Santos AJ; Penninger JM; Rieker-Geley T; Matsumoto G; Mak TM; Wick G. 1998. Thymic heterotypic cellular complexes in gene-targeted mice with defined blocks in T cell development and adhesion molecule expression. Eur J Immunol 28(9):2882-92. [PubMed: 9754575]  [MGI Ref ID J:49877]

Opavsky MA; Penninger J; Aitken K; Wen WH; Dawood F; Mak T; Liu P. 1999. Susceptibility to myocarditis is dependent on the response of alphabeta T lymphocytes to coxsackieviral infection. Circ Res 85(6):551-8. [PubMed: 10488058]  [MGI Ref ID J:114217]

Papouchado BG; Chapoval SP; Marietta EV; Weiler CR; David CS. 2001. Cockroach allergen-induced eosinophilic airway inflammation in HLA-DQ/human CD4(+) transgenic mice. J Immunol 167(8):4627-34. [PubMed: 11591792]  [MGI Ref ID J:130539]

Park JH; Adoro S; Lucas PJ; Sarafova SD; Alag AS; Doan LL; Erman B; Liu X; Ellmeier W; Bosselut R; Feigenbaum L; Singer A. 2007. 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nat Immunol 8(10):1049-59. [PubMed: 17873878]  [MGI Ref ID J:125259]

Pearce EL; Shedlock DJ; Shen H. 2004. Functional characterization of MHC class II-restricted CD8+CD4- and CD8-CD4- T cell responses to infection in CD4-/- mice. J Immunol 173(4):2494-9. [PubMed: 15294964]  [MGI Ref ID J:92690]

Penninger JM; Neu N; Timms E; Wallace VA; Koh DR; Kishihara K; Pummerer C; Mak TW. 1993. The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected] [published erratum appears in J Exp Med 1994 Jan 1;179(1):371] J Exp Med 178(5):1837-42. [PubMed: 8228830]  [MGI Ref ID J:15279]

Penninger JM; Sirard C; Mittrucker HW; Chidgey A; Kozieradzki I; Nghiem M; Hakem A; Kimura T; Timms E; Boyd R; Taniguchi T; Matsuyama T; Mak TW. 1997. The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes. Immunity 7(2):243-54. [PubMed: 9285409]  [MGI Ref ID J:111439]

Pien GC; Nguyen KB; Malmgaard L; Satoskar AR; Biron CA. 2002. A unique mechanism for innate cytokine promotion of T cell responses to viral infections. J Immunol 169(10):5827-37. [PubMed: 12421964]  [MGI Ref ID J:80075]

Rabb H; Daniels F; O'Donnell M; Haq M; Saba SR; Keane W; Tang WW. 2000. Pathophysiological role of T lymphocytes in renal ischemia-reperfusion injury in mice. Am J Physiol Renal Physiol 279(3):F525-31. [PubMed: 10966932]  [MGI Ref ID J:114177]

Rahemtulla A; Fung-Leung WP; Schilham MW; Kundig TM; Sambhara SR; Narendran A; Arabian A; Wakeham A; Paige CJ; Zinkernagel RM; et al.. 1991. Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4. Nature 353(6340):180-4. [PubMed: 1832488]  [MGI Ref ID J:68957]

Rahemtulla A; Kundig TM; Narendran A; Bachmann MF; Julius M; Paige CJ; Ohashi PS; Zinkernagel RM; Mak TW. 1994. Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice. Eur J Immunol 24(9):2213-8. [PubMed: 7916297]  [MGI Ref ID J:112988]

Rahemtulla A; Shahinian A; Kundig T; Zinkernagel R; Mak TW. 1993. CD4 negative mice as a model for immunodeficiency. Philos Trans R Soc Lond B Biol Sci 342(1299):57-8. [PubMed: 7904347]  [MGI Ref ID J:20507]

Roberts SJ; Ng BY; Filler RB; Lewis J; Glusac EJ; Hayday AC; Tigelaar RE; Girardi M. 2007. Characterizing tumor-promoting T cells in chemically induced cutaneous carcinogenesis. Proc Natl Acad Sci U S A 104(16):6770-5. [PubMed: 17412837]  [MGI Ref ID J:120942]

Rolan HG; Tsolis RM. 2007. Mice lacking components of adaptive immunity show increased Brucella abortus virB mutant colonization. Infect Immun 75(6):2965-73. [PubMed: 17420243]  [MGI Ref ID J:121919]

Rottenberg ME; Bakhiet M; Olsson T; Kristensson K; Mak T; Wigzell H; Orn A. 1993. Differential susceptibilities of mice genomically deleted of CD4 and CD8 to infections with Trypanosoma cruzi or Trypanosoma brucei. Infect Immun 61(12):5129-33. [PubMed: 8225589]  [MGI Ref ID J:111017]

Rottenberg ME; Gigliotti Rothfuchs AC; Gigliotti D; Svanholm C; Bandholtz L; Wigzell H. 1999. Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice. J Immunol 162(5):2829-36. [PubMed: 10072530]  [MGI Ref ID J:124536]

Rottenberg ME; Riarte A; Sporrong L; Altcheh J; Petray P; Ruiz AM; Wigzell H; Orn A. 1995. Outcome of infection with different strains of Trypanosoma cruzi in mice lacking CD4 and/or CD8. Immunol Lett 45(1-2):53-60. [PubMed: 7622189]  [MGI Ref ID J:112349]

Sarafova SD; Erman B; Yu Q; Van Laethem F; Guinter T; Sharrow SO; Feigenbaum L; Wildt KF; Ellmeier W; Singer A. 2005. Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity. Immunity 23(1):75-87. [PubMed: 16039581]  [MGI Ref ID J:100541]

Sarafova SD; Van Laethem F; Adoro S; Guinter T; Sharrow SO; Feigenbaum L; Singer A. 2009. Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice. Immunity 31(3):480-90. [PubMed: 19747858]  [MGI Ref ID J:152836]

Sardinha LR; Elias RM; Mosca T; Bastos KR; Marinho CR; D'Imperio Lima MR; Alvarez JM. 2006. Contribution of NK, NK T, gammadelta T, and alphabeta T cells to the gamma interferon response required for liver protection against Trypanosoma cruzi. Infect Immun 74(4):2031-42. [PubMed: 16552032]  [MGI Ref ID J:107423]

Sawa S; Kamimura D; Jin GH; Morikawa H; Kamon H; Nishihara M; Ishihara K; Murakami M; Hirano T. 2006. Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. J Exp Med 203(6):1459-70. [PubMed: 16717113]  [MGI Ref ID J:124381]

Schaeffer M; Han SJ; Chtanova T; van Dooren GG; Herzmark P; Chen Y; Roysam B; Striepen B; Robey EA. 2009. Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii. J Immunol 182(10):6379-93. [PubMed: 19414791]  [MGI Ref ID J:148321]

Schilham MW; Fung-Leung WP; Rahemtulla A; Kuendig T; Zhang L; Potter J; Miller RG; Hengartner H; Mak TW. 1993. Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8. Eur J Immunol 23(6):1299-304. [PubMed: 8500525]  [MGI Ref ID J:12572]

Senaldi G; Shaklee CL; Mak TW; Ulich TR. 1999. Corynebacterium parvum- and Mycobacterium bovis Bacillus Calmette and Guerin-induced granuloma formation in mice lacking CD4 and CD8. Cell Immunol 193(2):155-61. [PubMed: 10222057]  [MGI Ref ID J:114269]

Serbina NV; Lazarevic V; Flynn JL. 2001. CD4(+) T cells are required for the development of cytotoxic CD8(+) T cells during Mycobacterium tuberculosis infection. J Immunol 167(12):6991-7000. [PubMed: 11739519]  [MGI Ref ID J:73094]

Shedlock DJ; Whitmire JK; Tan J; MacDonald AS; Ahmed R; Shen H. 2003. Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection. J Immunol 170(4):2053-63. [PubMed: 12574376]  [MGI Ref ID J:126911]

Shen H; Whitmire JK; Fan X; Shedlock DJ; Kaech SM; Ahmed R. 2003. A specific role for B cells in the generation of CD8 T cell memory by recombinant Listeria monocytogenes. J Immunol 170(3):1443-51. [PubMed: 12538706]  [MGI Ref ID J:126273]

Shi FD; Li H; Wang H; Bai X; van der Meide PH; Link H; Ljunggren HG. 1999. Mechanisms of nasal tolerance induction in experimental autoimmune myasthenia gravis: identification of regulatory cells. J Immunol 162(10):5757-63. [PubMed: 10229808]  [MGI Ref ID J:120564]

Shi M; Wei G; Pan W; Tabel H. 2006. Experimental African trypanosomiasis: a subset of pathogenic, IFN-gamma-producing, MHC class II-restricted CD4+ T cells mediates early mortality in highly susceptible mice. J Immunol 176(3):1724-32. [PubMed: 16424202]  [MGI Ref ID J:126643]

Simard C; Klein SJ; Mak T; Jolicoeur P. 1997. Studies of the susceptibility of nude, CD4 knockout, and SCID mutant mice to the disease induced by the murine AIDS defective virus. J Virol 71(4):3013-22. [PubMed: 9060661]  [MGI Ref ID J:38897]

Skelsey ME; Mayhew E; Niederkorn JY. 2003. CD25+, interleukin-10-producing CD4+ T cells are required for suppressor cell production and immune privilege in the anterior chamber of the eye. Immunology 110(1):18-29. [PubMed: 12941137]  [MGI Ref ID J:113598]

Solaymani-Mohammadi S; Singer SM. 2011. Host immunity and pathogen strain contribute to intestinal disaccharidase impairment following gut infection. J Immunol 187(7):3769-75. [PubMed: 21873528]  [MGI Ref ID J:179334]

Strid J; Roberts SJ; Filler RB; Lewis JM; Kwong BY; Schpero W; Kaplan DH; Hayday AC; Girardi M. 2008. Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis. Nat Immunol 9(2):146-54. [PubMed: 18176566]  [MGI Ref ID J:131603]

Sun K; Metzger DW. 2008. Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection. Nat Med 14(5):558-64. [PubMed: 18438414]  [MGI Ref ID J:136669]

Sun Y; Blink SE; Chen JH; Fu YX. 2005. Regulation of follicular dendritic cell networks by activated T cells: the role of CD137 signaling. J Immunol 175(2):884-90. [PubMed: 16002686]  [MGI Ref ID J:100693]

Tada Y; Ho A; Koh DR; Mak TW. 1996. Collagen-induced arthritis in CD4- or CD8-deficient mice: CD8+ T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis. J Immunol 156(11):4520-6. [PubMed: 8666829]  [MGI Ref ID J:110669]

Taneja V; Taneja N; Paisansinsup T; Behrens M; Griffiths M; Luthra H; David CS. 2002. CD4 and CD8 T cells in susceptibility/protection to collagen-induced arthritis in HLA-DQ8-transgenic mice: implications for rheumatoid arthritis. J Immunol 168(11):5867-75. [PubMed: 12023391]  [MGI Ref ID J:134936]

Trcka J; Moroi Y; Clynes RA; Goldberg SM; Bergtold A; Perales MA; Ma M; Ferrone CR; Carroll MC; Ravetch JV; Houghton AN. 2002. Redundant and alternative roles for activating Fc receptors and complement in an antibody-dependent model of autoimmune vitiligo. Immunity 16(6):861-8. [PubMed: 12121667]  [MGI Ref ID J:113538]

Tsao PY; Jiao J; Ji MQ; Cohen PL; Eisenberg RA. 2008. T cell-independent spontaneous loss of tolerance by anti-double-stranded DNA B cells in C57BL/6 mice. J Immunol 181(11):7770-7. [PubMed: 19017966]  [MGI Ref ID J:142389]

Tyznik AJ; Sun JC; Bevan MJ. 2004. The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells. J Exp Med 199(4):559-65. [PubMed: 14769854]  [MGI Ref ID J:90469]

Tzelepis F; Persechini PM; Rodrigues MM. 2007. Modulation of CD4+ T cell-dependent specific cytotoxic CD8+ T cells differentiation and proliferation by the timing of increase in the pathogen load. PLoS ONE 2(4):e393. [PubMed: 17460760]  [MGI Ref ID J:129273]

Van Laethem F; Sarafova SD; Park JH; Tai X; Pobezinsky L; Guinter TI; Adoro S; Adams A; Sharrow SO; Feigenbaum L; Singer A. 2007. Deletion of CD4 and CD8 Coreceptors Permits Generation of alphabetaT Cells that Recognize Antigens Independently of the MHC. Immunity 27(5):735-50. [PubMed: 18023370]  [MGI Ref ID J:127623]

VanCott JL; McNeal MM; Flint J; Bailey SA; Choi AH; Ward RL. 2001. Role for T cell-independent B cell activity in the resolution of primary rotavirus infection in mice. Eur J Immunol 31(11):3380-7. [PubMed: 11745356]  [MGI Ref ID J:72616]

VanLith ML; Kohlgraf KG; Sivinski CL; Tempero RM; Hollingsworth MA. 2002. MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses. Int Immunol 14(8):873-82. [PubMed: 12147624]  [MGI Ref ID J:113544]

Vu MD; Amanullah F; Li Y; Demirci G; Sayegh MH; Li XC. 2004. Different costimulatory and growth factor requirements for CD4+ and CD8+ T cell-mediated rejection. J Immunol 173(1):214-21. [PubMed: 15210777]  [MGI Ref ID J:90930]

Wallace VA; Kondo S; Kono T; Xing Z; Timms E; Furlonger C; Keystone E; Gauldie J; Sauder DN; Mak TW; Paige CJ. 1994. A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin mice. Eur J Immunol 24(6):1463-6. [PubMed: 7911425]  [MGI Ref ID J:18913]

Wallace VA; Penninger J; Mak TW. 1994. T-Cell development in CD4, CD8, and p56(lck) Gene-Targeted mice.. In: Transgenesis and Targeted Mutagenesis in Immunology. Academic Press, Inc..  [MGI Ref ID J:21662]

Wallace VA; Rahemtulla A; Timms E; Penninger J; Mak TW. 1992. CD4 expression is differentially required for deletion of MLS-1a-reactive T cells. J Exp Med 176(5):1459-63. [PubMed: 1402689]  [MGI Ref ID J:110753]

Walton SM; Torti N; Mandaric S; Oxenius A. 2011. T-cell help permits memory CD8(+) T-cell inflation during cytomegalovirus latency. Eur J Immunol 41(8):2248-59. [PubMed: 21590767]  [MGI Ref ID J:176830]

Wang B; Fujisawa H; Zhuang L; Freed I; Howell BG; Shahid S; Shivji GM; Mak TW; Sauder DN. 2000. CD4(+) Th1 and CD8(+) type 1 cytotoxic T cells both play a crucial role in the full development of contact hypersensitivity J Immunol 165(12):6783-90. [PubMed: 11120799]  [MGI Ref ID J:66170]

Wang C; Hino A; Yoshimoto T; Nagase H; Kato T; Hirokawa K; Matsuzawa A; Nariuchi H. 2000. Impaired delayed-type hypersensitivity response in mutant mice secreting soluble CD4 without expression of membrane-bound CD4 Immunology 100(3):309-16. [PubMed: 10929052]  [MGI Ref ID J:63431]

Wang T; Chen L; Ahmed E; Ma L; Yin D; Zhou P; Shen J; Xu H; Wang CR; Alegre ML; Chong AS. 2008. Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes. J Immunol 180(9):5991-9. [PubMed: 18424719]  [MGI Ref ID J:134678]

Wen T; Trumper L; Fung-Leung W; Rahemtulla A; Klein E; Klein G; Mak TW. 1998. Requirement of the CD8+ or CD4+ T lymphocyte subsets for the rejection of lymphoma and fibrosarcoma grafts studied in gene knockout hosts. Immunol Lett 61(2-3):187-90. [PubMed: 9657273]  [MGI Ref ID J:47925]

Weng X; Priceputu E; Chrobak P; Poudrier J; Kay DG; Hanna Z; Mak TW; Jolicoeur P. 2004. CD4+ T cells from CD4C/HIVNef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro but are dispensable for the development of a severe AIDS-like organ disease. J Virol 78(10):5244-57. [PubMed: 15113906]  [MGI Ref ID J:89588]

Wiesel M; Joller N; Ehlert AK; Crouse J; Sporri R; Bachmann MF; Oxenius A. 2010. Th cells act via two synergistic pathways to promote antiviral CD8+ T cell responses. J Immunol 185(9):5188-97. [PubMed: 20881183]  [MGI Ref ID J:165190]

Wiesel M; Kratky W; Oxenius A. 2011. Type I IFN substitutes for T cell help during viral infections. J Immunol 186(2):754-63. [PubMed: 21160039]  [MGI Ref ID J:168770]

Wolfort RM; Stokes KY; Granger DN. 2008. CD4+ T lymphocytes mediate hypercholesterolemia-induced endothelial dysfunction via a NAD(P)H oxidase-dependent mechanism. Am J Physiol Heart Circ Physiol 294(6):H2619-26. [PubMed: 18408127]  [MGI Ref ID J:136828]

Xiang J; Huang H; Liu Y. 2005. A new dynamic model of CD8+ T effector cell responses via CD4+ T helper-antigen-presenting cells. J Immunol 174(12):7497-505. [PubMed: 15944248]  [MGI Ref ID J:100792]

Xin H; Kikuchi T; Andarini S; Ohkouchi S; Suzuki T; Nukiwa T; Hagiwara K; Honjo T; Saijo Y. 2005. Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells. Eur J Immunol 35(5):1371-80. [PubMed: 15789339]  [MGI Ref ID J:97809]

Yang PL; Althage A; Chung J; Maier H; Wieland S; Isogawa M; Chisari FV. 2010. Immune effectors required for hepatitis B virus clearance. Proc Natl Acad Sci U S A 107(2):798-802. [PubMed: 20080755]  [MGI Ref ID J:156523]

Yi JS; Du M; Zajac AJ. 2009. A vital role for interleukin-21 in the control of a chronic viral infection. Science 324(5934):1572-6. [PubMed: 19443735]  [MGI Ref ID J:150002]

Yi JS; Ingram JT; Zajac AJ. 2010. IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection. J Immunol 185(8):4835-45. [PubMed: 20844201]  [MGI Ref ID J:164735]

Yuan X; Ansari MJ; D'Addio F; Paez-Cortez J; Schmitt I; Donnarumma M; Boenisch O; Zhao X; Popoola J; Clarkson MR; Yagita H; Akiba H; Freeman GJ; Iacomini J; Turka LA; Glimcher LH; Sayegh MH. 2009. Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proc Natl Acad Sci U S A 106(26):10734-9. [PubMed: 19528638]  [MGI Ref ID J:150842]

Yusuf N; Nasti TH; Katiyar SK; Jacobs MK; Seibert MD; Ginsburg AC; Timares L; Xu H; Elmets CA. 2008. Antagonistic roles of CD4+ and CD8+ T-cells in 7,12-dimethylbenz(a)anthracene cutaneous carcinogenesis. Cancer Res 68(10):3924-30. [PubMed: 18483278]  [MGI Ref ID J:135019]

Zhang GX; Xiao BG; Bakhiet M; van der Meide P; Wigzell H; Link H; Olsson T. 1996. Both CD4+ and CD8+ T cells are essential to induce experimental autoimmune myasthenia gravis. J Exp Med 184(2):349-56. [PubMed: 8760788]  [MGI Ref ID J:110750]

Zhu Y; Bao L; Zhu S; Chen Z; van der Meide P; Nennesmo I; Winblad B; Ljunggren HG; Zhu J. 2002. CD4 and CD8 T cells, but not B cells, are critical to the control of murine experimental autoimmune neuritis. Exp Neurol 177(1):314-20. [PubMed: 12429233]  [MGI Ref ID J:118779]

de Visser KE; Korets LV; Coussens LM. 2005. De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell 7(5):411-23. [PubMed: 15894262]  [MGI Ref ID J:98942]

Cd8a^tm1Mak related

Alard P; Clark SL; Kosiewicz MM. 2004. Mechanisms of tolerance induced by TGF beta-treated APC: CD4 regulatory T cells prevent the induction of the immune response possibly through a mechanism involving TGF beta. Eur J Immunol 34(4):1021-30. [PubMed: 15048712]  [MGI Ref ID J:115475]

Andrews NP; Pack CD; Lukacher AE. 2008. Generation of antiviral major histocompatibility complex class I-restricted T cells in the absence of CD8 coreceptors. J Virol 82(10):4697-705. [PubMed: 18337581]  [MGI Ref ID J:153304]

Antony PA; Piccirillo CA; Akpinarli A; Finkelstein SE; Speiss PJ; Surman DR; Palmer DC; Chan CC; Klebanoff CA; Overwijk WW; Rosenberg SA; Restifo NP. 2005. CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells. J Immunol 174(5):2591-601. [PubMed: 15728465]  [MGI Ref ID J:129825]

Bachmaier K; Neu N; Yeung RS; Mak TW; Liu P; Penninger JM. 1999. Generation of humanized mice susceptible to peptide-induced inflammatory heart disease. Circulation 99(14):1885-91. [PubMed: 10199887]  [MGI Ref ID J:129115]

Bachmann MF; Oxenius A; Mak TW; Zinkernagel RM. 1995. T cell development in CD8-/- mice. Thymic positive selection is biased toward the helper phenotype. J Immunol 155(8):3727-33. [PubMed: 7561076]  [MGI Ref ID J:29580]

Barnes MJ; Aksoylar H; Krebs P; Bourdeau T; Arnold CN; Xia Y; Khovananth K; Engel I; Sovath S; Lampe K; Laws E; Saunders A; Butcher GW; Kronenberg M; Steinbrecher K; Hildeman D; Grimes HL; Beutler B; Hoebe K. 2010. Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice. J Immunol 184(7):3743-54. [PubMed: 20190135]  [MGI Ref ID J:160090]

Beilke JN; Kuhl NR; Van Kaer L; Gill RG. 2005. NK cells promote islet allograft tolerance via a perforin-dependent mechanism. Nat Med 11(10):1059-65. [PubMed: 16155578]  [MGI Ref ID J:101693]

Belkaid Y; Von Stebut E; Mendez S; Lira R; Caler E; Bertholet S; Udey MC; Sacks D. 2002. CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major. J Immunol 168(8):3992-4000. [PubMed: 11937556]  [MGI Ref ID J:125458]

Ben-David H; Sharabi A; Dayan M; Sela M; Mozes E. 2007. The role of CD8+CD28 regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand. Proc Natl Acad Sci U S A 104(44):17459-64. [PubMed: 17956982]  [MGI Ref ID J:127105]

Berke Z; Wen T; Jin S; Klein G; Dalianis T. 1995. Polyomavirus persists in CD4/8 double-knockout, but not in CD4 or CD8 single-knockout mice. Virology 212(1):268-71. [PubMed: 7676644]  [MGI Ref ID J:110749]

Berke Z; Wen T; Klein G; Dalianis T. 1996. Polyoma tumor development in neonatally polyoma-virus-infected CD4-/- and CD8-/- single knockout and CD4-/-8-/- double knockout mice. Int J Cancer 67(3):405-8. [PubMed: 8707416]  [MGI Ref ID J:113042]

Bhadra R; Gigley JP; Khan IA. 2011. Cutting edge: CD40-CD40 ligand pathway plays a critical CD8-intrinsic and -extrinsic role during rescue of exhausted CD8 T cells. J Immunol 187(9):4421-5. [PubMed: 21949017]  [MGI Ref ID J:179445]

Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. [PubMed: 15153508]  [MGI Ref ID J:90518]

Bitsaktsis C; Nandi B; Racine R; MacNamara KC; Winslow G. 2007. T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection. Infect Immun 75(10):4933-41. [PubMed: 17664264]  [MGI Ref ID J:125283]

Bitsaktsis C; Winslow G. 2006. Fatal recall responses mediated by CD8 T cells during intracellular bacterial challenge infection. J Immunol 177(7):4644-51. [PubMed: 16982903]  [MGI Ref ID J:139316]

Boenisch O; D'Addio F; Watanabe T; Elyaman W; Magee CN; Yeung MY; Padera RF; Rodig SJ; Murayama T; Tanaka K; Yuan X; Ueno T; Jurisch A; Mfarrej B; Akiba H; Yagita H; Najafian N. 2010. TIM-3: a novel regulatory molecule of alloimmune activation. J Immunol 185(10):5806-19. [PubMed: 20956339]  [MGI Ref ID J:165781]

Bommireddy R; Engle SJ; Ormsby I; Boivin GP; Babcock GF; Doetschman T. 2004. Elimination of both CD4(+) and CD8(+) T cells but not B cells eliminates inflammation and prolongs the survival of TGFbeta1-deficient mice. Cell Immunol 232(1-2):96-104. [PubMed: 15922720]  [MGI Ref ID J:99033]

Borenstein SH; Graham J; Zhang XL; Chamberlain JW. 2000. CD8+ T cells are necessary for recognition of allelic, but not locus-mismatched or xeno-, HLA class I transplantation antigens. J Immunol 165(5):2341-53. [PubMed: 10946256]  [MGI Ref ID J:80678]

Bosselut R; Feigenbaum L; Sharrow SO; Singer A. 2001. Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes. Immunity 14(4):483-94. [PubMed: 11336693]  [MGI Ref ID J:132432]

Brochard V; Combadiere B; Prigent A; Laouar Y; Perrin A; Beray-Berthat V; Bonduelle O; Alvarez-Fischer D; Callebert J; Launay JM; Duyckaerts C; Flavell RA; Hirsch EC; Hunot S. 2009. Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest 119(1):182-92. [PubMed: 19104149]  [MGI Ref ID J:144702]

Bry L; Brenner MB. 2004. Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol 172(1):433-41. [PubMed: 14688352]  [MGI Ref ID J:87077]

Bumgardner GL; Gao D; Li J; Baskin JH; Heininger M; Orosz CG. 2000. Rejection responses to allogeneic hepatocytes by reconstituted SCID mice, CD4, KO, and CD8 KO mice. Transplantation 70(12):1771-80. [PubMed: 11152110]  [MGI Ref ID J:66571]

Burne MJ; Daniels F; El Ghandour A; Mauiyyedi S; Colvin RB; O'Donnell MP; Rabb H. 2001. Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure. J Clin Invest 108(9):1283-90. [PubMed: 11696572]  [MGI Ref ID J:118005]

Cardoso EM; Macedo MG; Rohrlich P; Ribeiro E; Silva MT; Lemonnier FA; de Sousa M. 2002. Increased hepatic iron in mice lacking classical MHC class I molecules. Blood 100(12):4239-41. [PubMed: 12393413]  [MGI Ref ID J:115559]

Chan WC; Duong TT; Yeung RS. 2004. Presence of IFN-gamma does not indicate its necessity for induction of coronary arteritis in an animal model of Kawasaki disease. J Immunol 173(5):3492-503. [PubMed: 15322214]  [MGI Ref ID J:92708]

Chen SY; Takeoka Y; Ansari AA; Boyd R; Klinman DM; Gershwin ME. 1996. The natural history of disease expression in CD4 and CD8 gene-deleted New Zealand black (NZB) mice. J Immunol 157(6):2676-84. [PubMed: 8805673]  [MGI Ref ID J:35433]

Chen Z; Yu S; Concha HQ; Zhu Y; Mix E; Winblad B; Ljunggren HG; Zhu J. 2004. Kainic acid-induced excitotoxic hippocampal neurodegeneration in C57BL/6 mice: B cell and T cell subsets may contribute differently to the pathogenesis. Brain Behav Immun 18(2):175-85. [PubMed: 14759595]  [MGI Ref ID J:105331]

Chiang EY; Stroynowski I. 2004. A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor. J Immunol 173(7):4394-401. [PubMed: 15383569]  [MGI Ref ID J:93729]

Ciurea A; Hunziker L; Klenerman P; Hengartner H; Zinkernagel RM. 2001. Impairment of CD4(+) T cell responses during chronic virus infection prevents neutralizing antibody responses against virus escape mutants. J Exp Med 193(3):297-305. [PubMed: 11157050]  [MGI Ref ID J:124426]

Crosby JR; Shen HH; Borchers MT; Justice JP; Ansay T; Lee JJ; Lee NA. 2002. Ectopic expression of IL-5 identifies an additional CD4(+) T cell mechanism of airway eosinophil recruitment. Am J Physiol Lung Cell Mol Physiol 282(1):L99-108. [PubMed: 11741821]  [MGI Ref ID J:107840]

Cui W; Liu Y; Weinstein JS; Craft J; Kaech SM. 2011. An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8(+) T Cells. Immunity 35(5):792-805. [PubMed: 22118527]  [MGI Ref ID J:178927]

D'Souza CD; Cooper AM; Frank AA; Ehlers S; Turner J; Bendelac A; Orme IM. 2000. A novel nonclassic beta2-microglobulin-restricted mechanism influencing early lymphocyte accumulation and subsequent resistance to tuberculosis in the lung. Am J Respir Cell Mol Biol 23(2):188-93. [PubMed: 10919985]  [MGI Ref ID J:114179]

Dalloul AH; Ngo K; Fung-Leung WP. 1996. CD4-negative cytotoxic T cells with a T cell receptor alpha/beta intermediate expression in CD8-deficient mice. Eur J Immunol 26(1):213-8. [PubMed: 8566069]  [MGI Ref ID J:112982]

Daniel D; Meyer-Morse N; Bergsland EK; Dehne K; Coussens LM; Hanahan D. 2003. Immune Enhancement of Skin Carcinogenesis by CD4+ T Cells. J Exp Med 197(8):1017-28. [PubMed: 12695493]  [MGI Ref ID J:82978]

DeNardo DG; Barreto JB; Andreu P; Vasquez L; Tawfik D; Kolhatkar N; Coussens LM. 2009. CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 16(2):91-102. [PubMed: 19647220]  [MGI Ref ID J:151976]

Dragovic SM; Hill T; Christianson GJ; Kim S; Elliott T; Scott D; Roopenian DC; Van Kaer L; Joyce S. 2011. Proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ Th cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigens. J Immunol 186(12):6683-92. [PubMed: 21572029]  [MGI Ref ID J:175483]

Drake DR 3rd; Lukacher AE. 1998. Beta 2-microglobulin knockout mice are highly susceptible to polyoma virus tumorigenesis. Virology 252(1):275-84. [PubMed: 9875336]  [MGI Ref ID J:52185]

Duong TT; Silverman ED; Bissessar MV; Yeung RS. 2003. Superantigenic activity is responsible for induction of coronary arteritis in mice: an animal model of Kawasaki disease. Int Immunol 15(1):79-89. [PubMed: 12502728]  [MGI Ref ID J:81746]

Duthie MS; Kahn SJ. 2006. During acute Trypanosoma cruzi infection highly susceptible mice deficient in natural killer cells are protected by a single alpha-galactosylceramide treatment. Immunology 119(3):355-61. [PubMed: 16879622]  [MGI Ref ID J:118525]

Ehinger M; Vestberg M; Johansson AC; Johannesson M; Svensson A; Holmdahl R. 2001. Influence of CD4 or CD8 deficiency on collagen-induced arthritis. Immunology 103(3):291-300. [PubMed: 11454058]  [MGI Ref ID J:110421]

Ehst BD; Ingulli E; Jenkins MK. 2003. Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection. Am J Transplant 3(11):1355-62. [PubMed: 14525595]  [MGI Ref ID J:91742]

Elhage R; Gourdy P; Brouchet L; Jawien J; Fouque MJ; Fievet C; Huc X; Barreira Y; Couloumiers JC; Arnal JF; Bayard F. 2004. Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice. Am J Pathol 165(6):2013-8. [PubMed: 15579444]  [MGI Ref ID J:94976]

Engel I; Hammond K; Sullivan BA; He X; Taniuchi I; Kappes D; Kronenberg M. 2010. Co-receptor choice by V alpha14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection. J Exp Med 207(5):1015-29. [PubMed: 20404101]  [MGI Ref ID J:161237]

Enoh VT; Fairchild CD; Lin CY; Varma TK; Sherwood ER. 2006. Differential effect of imipenem treatment on wild-type and NK cell-deficient CD8 knockout mice during acute intra-abdominal injury. Am J Physiol Regul Integr Comp Physiol 290(3):R685-93. [PubMed: 16269570]  [MGI Ref ID J:105682]

Erman B; Alag AS; Dahle O; van Laethem F; Sarafova SD; Guinter TI; Sharrow SO; Grinberg A; Love PE; Singer A. 2006. Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model. J Immunol 177(10):6613-25. [PubMed: 17082573]  [MGI Ref ID J:126026]

Evel-Kabler K; Song XT; Aldrich M; Huang XF; Chen SY. 2006. SOCS1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling. J Clin Invest 116(1):90-100. [PubMed: 16357940]  [MGI Ref ID J:105256]

Fang M; Sigal LJ. 2005. Antibodies and CD8+ T cells are complementary and essential for natural resistance to a highly lethal cytopathic virus. J Immunol 175(10):6829-36. [PubMed: 16272340]  [MGI Ref ID J:119697]

Fischbein MP; Ardehali A; Yun J; Schoenberger S; Laks H; Irie Y; Dempsey P; Cheng G; Fishbein MC; Bonavida B. 2000. CD40 signaling replaces CD4+ lymphocytes and its blocking prevents chronic rejection of heart transplants. J Immunol 165(12):7316-22. [PubMed: 11120867]  [MGI Ref ID J:118395]

Ford MS; Zhang ZX; Chen W; Zhang L. 2006. Double-negative T regulatory cells can develop outside the thymus and do not mature from CD8+ T cell precursors. J Immunol 177(5):2803-9. [PubMed: 16920915]  [MGI Ref ID J:139556]

Foucras G; Coudert JD; Coureau C; Guery JC. 2000. Dendritic cells prime in vivo alloreactive CD4 T lymphocytes toward type 2 cytokine- and TGF-beta-producing cells in the absence of CD8 T cell activation. J Immunol 165(9):4994-5003. [PubMed: 11046027]  [MGI Ref ID J:118923]

Fragoso RC; Pyarajan S; Irie HY; Burakoff SJ. 2006. A CD8/Lck transgene is able to drive thymocyte differentiation. J Immunol 177(9):6007-17. [PubMed: 17056525]  [MGI Ref ID J:140528]

Freland S; Ljunggren H. 2000. beta2-Microglobulin/CD8 -/- mice reveal significant role for CD8+ T cells in graft rejection responses in beta2-microglobulin -/- mice Scand J Immunol 51(3):219-23. [PubMed: 10736089]  [MGI Ref ID J:61231]

French JD; Roark CL; Born WK; O'brien RL. 2005. {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells. Proc Natl Acad Sci U S A 102(41):14741-6. [PubMed: 16203967]  [MGI Ref ID J:102497]

Friedline RH ; Brown DS ; Nguyen H ; Kornfeld H ; Lee J ; Zhang Y ; Appleby M ; Der SD ; Kang J ; Chambers CA. 2009. CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. J Exp Med 206(2):421-34. [PubMed: 19188497]  [MGI Ref ID J:146644]

Fujii S; Goto A; Shimizu K. 2009. Antigen mRNA-transfected, allogeneic fibroblasts loaded with NKT-cell ligand confer antitumor immunity. Blood 113(18):4262-72. [PubMed: 19164596]  [MGI Ref ID J:148431]

Fung-Leung WP; Louie MC; Limmer A; Ohashi PS; Ngo K; Chen L; Kawai K; Lacy E; Loh DY; Mak TW. 1993. The lack of CD8 alpha cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes. Eur J Immunol 23(11):2834-40. [PubMed: 8223860]  [MGI Ref ID J:113044]

Fung-Leung WP; Schilham MW; Rahemtulla A; Kundig TM; Vollenweider M; Potter J; van Ewijk W; Mak TW. 1991. CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell 65(3):443-9. [PubMed: 1673361]  [MGI Ref ID J:68956]

Fung-Leung WP; Wallace VA; Gray D; Sha WC; Pircher H; Teh HS; Loh DY; Mak TW. 1993. CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny. Eur J Immunol 23(1):212-6. [PubMed: 8419174]  [MGI Ref ID J:112993]

Gao Y; Tao J; Li MO; Zhang D; Chi H; Henegariu O; Kaech SM; Davis RJ; Flavell RA; Yin Z. 2005. JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance. J Immunol 175(9):5783-9. [PubMed: 16237070]  [MGI Ref ID J:119340]

Goldszmid RS; Bafica A; Jankovic D; Feng CG; Caspar P; Winkler-Pickett R; Trinchieri G; Sher A. 2007. TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-{gamma} production. J Exp Med 204(11):2591-602. [PubMed: 17923502]  [MGI Ref ID J:126112]

Gorbachev AV; Fairchild RL. 2004. CD40 engagement enhances antigen-presenting langerhans cell priming of IFN-gamma-producing CD4+ and CD8+ T cells independently of IL-12. J Immunol 173(4):2443-52. [PubMed: 15294958]  [MGI Ref ID J:92689]

Gramaglia I; Sahlin H; Nolan JP; Frangos JA; Intaglietta M; van der Heyde HC. 2005. Cell- rather than antibody-mediated immunity leads to the development of profound thrombocytopenia during experimental Plasmodium berghei malaria. J Immunol 175(11):7699-707. [PubMed: 16301680]  [MGI Ref ID J:122163]

Grayson MH; Cheung D; Rohlfing MM; Kitchens R; Spiegel DE; Tucker J; Battaile JT; Alevy Y; Yan L; Agapov E; Kim EY; Holtzman MJ. 2007. Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. J Exp Med 204(11):2759-69. [PubMed: 17954569]  [MGI Ref ID J:126124]

Grdic D; Hornquist E; Kjerrulf M; Lycke NY. 1998. Lack of local suppression in orally tolerant CD8-deficient mice reveals a critical regulatory role of CD8+ T cells in the normal gut mucosa. J Immunol 160(2):754-62. [PubMed: 9551910]  [MGI Ref ID J:45177]

Guleria I; Gubbels Bupp M; Dada S; Fife B; Tang Q; Ansari MJ; Trikudanathan S; Vadivel N; Fiorina P; Yagita H; Azuma M; Atkinson M; Bluestone JA; Sayegh MH. 2007. Mechanisms of PDL1-mediated regulation of autoimmune diabetes. Clin Immunol 125(1):16-25. [PubMed: 17627890]  [MGI Ref ID J:125272]

Hancock WW; Tsai TL; Madaio MP; Gasser DL. 2003. Cutting Edge: Multiple autoimmune pathways in kd/kd mice. J Immunol 171(6):2778-81. [PubMed: 12960297]  [MGI Ref ID J:85380]

He X; He X; Dave VP; Zhang Y; Hua X; Nicolas E; Xu W; Roe BA; Kappes DJ. 2005. The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature 433(7028):826-33. [PubMed: 15729333]  [MGI Ref ID J:95867]

Hegde S; Niederkorn JY. 2000. The role of cytotoxic T lymphocytes in corneal allograft rejection. Invest Ophthalmol Vis Sci 41(11):3341-7. [PubMed: 11006223]  [MGI Ref ID J:115389]

Hida S; Ogasawara K; Sato K; Abe M; Takayanagi H; Yokochi T; Sato T; Hirose S; Shirai T; Taki S; Taniguchi T. 2000. CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling Immunity 13(5):643-55. [PubMed: 11114377]  [MGI Ref ID J:66034]

Hornquist CE; Ekman L; Grdic KD; Schon K; Lycke NY. 1995. Paradoxical IgA immunity in CD4-deficient mice. Lack of cholera toxin-specific protective immunity despite normal gut mucosal IgA differentiation. J Immunol 155(6):2877-87. [PubMed: 7673704]  [MGI Ref ID J:110845]

Huber M; Timms E; Mak TW; Rollinghoff M; Lohoff M. 1998. Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice. Infect Immun 66(8):3968-70. [PubMed: 9673288]  [MGI Ref ID J:48826]

Hung K; Hayashi R; Lafond-Walker A; Lowenstein C; Pardoll D; Levitsky H. 1998. The central role of CD4(+) T cells in the antitumor immune response. J Exp Med 188(12):2357-68. [PubMed: 9858522]  [MGI Ref ID J:51677]

Hussell T; Openshaw PJ. 2000. IL-12-activated NK cells reduce lung eosinophilia to the attachment protein of respiratory syncytial virus but do not enhance the severity of illness in CD8 T cell-immunodeficient conditions. J Immunol 165(12):7109-15. [PubMed: 11120841]  [MGI Ref ID J:118396]

Iannacone M; Sitia G; Isogawa M; Whitmire JK; Marchese P; Chisari FV; Ruggeri ZM; Guidotti LG. 2008. Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus. Proc Natl Acad Sci U S A 105(2):629-34. [PubMed: 18184798]  [MGI Ref ID J:131089]

Ip CW; Kroner A; Bendszus M; Leder C; Kobsar I; Fischer S; Wiendl H; Nave KA; Martini R. 2006. Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes. J Neurosci 26(31):8206-16. [PubMed: 16885234]  [MGI Ref ID J:111136]

Joetham A; Okamoto M; Takeda K; Schedel M; Ohnishi H; Dakhama A; Gelfand EW. 2011. CD8 regulates T regulatory cell production of IL-6 and maintains their suppressive phenotype in allergic lung disease. J Immunol 186(1):113-20. [PubMed: 21115736]  [MGI Ref ID J:168721]

Joetham A; Takeda K; Miyahara N; Matsubara S; Ohnishi H; Koya T; Dakhama A; Gelfand EW. 2007. Activation of naturally occurring lung CD4+CD25+ regulatory T cells requires CD8 and MHC I interaction. Proc Natl Acad Sci U S A 104(38):15057-62. [PubMed: 17855564]  [MGI Ref ID J:125195]

Justice JP; Crosby J; Borchers MT; Tomkinson A; Lee JJ; Lee NA. 2002. CD4(+) T cell-dependent airway mucus production occurs in response to IL-5 expression in lung. Am J Physiol Lung Cell Mol Physiol 282(5):L1066-74. [PubMed: 11943672]  [MGI Ref ID J:108354]

Kanakaraj P; Schafer PH; Cavender DE; Wu Y; Ngo K; Grealish PF; Wadsworth SA; Peterson PA; Siekierka JJ; Harris CA; Fung-Leung WP. 1998. Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production. J Exp Med 187(12):2073-9. [PubMed: 9625767]  [MGI Ref ID J:110860]

Kang TW; Yevsa T; Woller N; Hoenicke L; Wuestefeld T; Dauch D; Hohmeyer A; Gereke M; Rudalska R; Potapova A; Iken M; Vucur M; Weiss S; Heikenwalder M; Khan S; Gil J; Bruder D; Manns M; Schirmacher P; Tacke F; Ott M; Luedde T; Longerich T; Kubicka S; Zender L. 2011. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 479(7374):547-51. [PubMed: 22080947]  [MGI Ref ID J:179823]

Khan IA; Schwartzman JD; Kasper LH; Moretto M. 1999. CD8+ CTLs are essential for protective immunity against Encephalitozoon cuniculi infection. J Immunol 162(10):6086-91. [PubMed: 10229850]  [MGI Ref ID J:120238]

Kikuchi T; Andarini S; Xin H; Gomi K; Tokue Y; Saijo Y; Honjo T; Watanabe A; Nukiwa T. 2005. Involvement of fractalkine/CX3CL1 expression by dendritic cells in the enhancement of host immunity against Legionella pneumophila. Infect Immun 73(9):5350-7. [PubMed: 16113250]  [MGI Ref ID J:100418]

Kimura T; Griffin DE. 2000. The role of CD8(+) T cells and major histocompatibility complex class I expression in the central nervous system of mice infected with neurovirulent Sindbis virus. J Virol 74(13):6117-25. [PubMed: 10846095]  [MGI Ref ID J:126435]

Kish DD; Li X; Fairchild RL. 2009. CD8 T cells producing IL-17 and IFN-gamma initiate the innate immune response required for responses to antigen skin challenge. J Immunol 182(10):5949-59. [PubMed: 19414746]  [MGI Ref ID J:148247]

Klein MA; Frigg R; Flechsig E; Raeber AJ; Kalinke U; Bluethmann H; Bootz F; Suter M; Zinkernagel RM; Aguzzi A. 1997. A crucial role for B cells in neuroinvasive scrapie [see comments] Nature 390(6661):687-90. [PubMed: 9414161]  [MGI Ref ID J:44933]

Kobrynski LJ; Sousa AO; Nahmias AJ; Lee FK. 2005. Cutting edge: antibody production to pneumococcal polysaccharides requires CD1 molecules and CD8+ T cells. J Immunol 174(4):1787-90. [PubMed: 15699104]  [MGI Ref ID J:96541]

Koh DR; Fung-Leung WP; Ho A; Gray D; Acha-Orbea H; Mak TW. 1992. Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice. Science 256(5060):1210-3. [PubMed: 1589800]  [MGI Ref ID J:1033]

Koh DR; Ho A; Rahemtulla A; Fung-Leung WP; Griesser H; Mak TW. 1995. Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells. Eur J Immunol 25(9):2558-62. [PubMed: 7589126]  [MGI Ref ID J:28923]

Kosiewicz MM; Alard P; Liang S; Clark SL. 2004. Mechanisms of tolerance induced by transforming growth factor-beta-treated antigen-presenting cells: CD8 regulatory T cells inhibit the effector phase of the immune response in primed mice through a mechanism involving Fas ligand. Int Immunol 16(5):697-706. [PubMed: 15096489]  [MGI Ref ID J:89454]

Koya T; Matsuda H; Matsubara S; Miyahara N; Dakhama A; Takeda K; Gelfand EW. 2009. Differential effects of dendritic cell transfer on airway hyperresponsiveness and inflammation. Am J Respir Cell Mol Biol 41(3):271-80. [PubMed: 19151321]  [MGI Ref ID J:164635]

Lacorazza HD; Nikolich-Zugich J. 2004. Exclusion and inclusion of TCR alpha proteins during T cell development in TCR-transgenic and normal mice. J Immunol 173(9):5591-600. [PubMed: 15494509]  [MGI Ref ID J:132808]

Laffont S; Seillet C; Ortaldo J; Coudert JD; Guery JC. 2008. Natural killer cells recruited into lymph nodes inhibit alloreactive T-cell activation through perforin-mediated killing of donor allogeneic dendritic cells. Blood 112(3):661-71. [PubMed: 18505782]  [MGI Ref ID J:138424]

Lesourne R; Uehara S; Lee J; Song KD; Li L; Pinkhasov J; Zhang Y; Weng NP; Wildt KF; Wang L; Bosselut R; Love PE. 2009. Themis, a T cell-specific protein important for late thymocyte development. Nat Immunol 10(8):840-7. [PubMed: 19597498]  [MGI Ref ID J:151075]

Lin X; Ma X; Rodriguez M; Roos RP. 2004. CD4+ T cells are important for clearance of DA strain of TMEV from the central nervous system of SJL/J mice. Int Immunol 16(9):1237-40. [PubMed: 15262897]  [MGI Ref ID J:91962]

Lin X; Pease LR; Murray PD; Rodriguez M. 1998. Theiler's virus infection of genetically susceptible mice induces central nervous system-infiltrating CTLs with no apparent viral or major myelin antigenic specificity. J Immunol 160(11):5661-8. [PubMed: 9605173]  [MGI Ref ID J:47789]

Liu M; Chien CC; Burne-Taney M; Molls RR; Racusen LC; Colvin RB; Rabb H. 2006. A pathophysiologic role for T lymphocytes in murine acute cisplatin nephrotoxicity. J Am Soc Nephrol 17(3):765-74. [PubMed: 16481417]  [MGI Ref ID J:135790]

Liu P; Aitken K; Kong YY; Opavsky MA; Martino T; Dawood F; Wen WH; Kozieradzki I; Bachmaier K; Straus D; Mak TW; Penninger JM. 2000. The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease. Nat Med 6(4):429-34. [PubMed: 10742150]  [MGI Ref ID J:119597]

Liu R; Van Kaer L; La Cava A; Price M; Campagnolo DI; Collins M; Young DA; Vollmer TL; Shi FD. 2006. Autoreactive T cells mediate NK cell degeneration in autoimmune disease. J Immunol 176(9):5247-54. [PubMed: 16621990]  [MGI Ref ID J:131629]

Liu Y; Teige A; Mondoc E; Ibrahim S; Holmdahl R; Issazadeh-Navikas S. 2011. Endogenous collagen peptide activation of CD1d-restricted NKT cells ameliorates tissue-specific inflammation in mice. J Clin Invest 121(1):249-64. [PubMed: 21157037]  [MGI Ref ID J:171844]

Maeno T; Houghton AM; Quintero PA; Grumelli S; Owen CA; Shapiro SD. 2007. CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice. J Immunol 178(12):8090-6. [PubMed: 17548647]  [MGI Ref ID J:148578]

Maldonado MA; MacDonald GC; Kakkanaiah VN; Fecho K; Dransfield M; Sekiguchi D; Cohen PL; Eisenberg RA. 1999. Differential control of autoantibodies and lymphoproliferation by Fas ligand expression on CD4+ and CD8+ T cells in vivo. J Immunol 163(6):3138-42. [PubMed: 10477580]  [MGI Ref ID J:119603]

Marquis M; Lewandowski D; Dugas V; Aumont F; Senechal S; Jolicoeur P; Hanna Z; de Repentigny L. 2006. CD8+ T cells but not polymorphonuclear leukocytes are required to limit chronic oral carriage of Candida albicans in transgenic mice expressing human immunodeficiency virus type 1. Infect Immun 74(4):2382-91. [PubMed: 16552068]  [MGI Ref ID J:107387]

Matheson JM; Johnson VJ; Luster MI. 2005. Immune mediators in a murine model for occupational asthma: studies with toluene diisocyanate. Toxicol Sci 84(1):99-109. [PubMed: 15590890]  [MGI Ref ID J:106452]

Meehan TF; DeLuca HF. 2002. CD8+ T cells are not necessary for 1alpha,25-dihydroxyvitamin D3 to suppress experimental autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A 99(8):5557-60. [PubMed: 11929984]  [MGI Ref ID J:76066]

Meissner NN; Lund FE; Han S; Harmsen A. 2005. CD8 T cell-mediated lung damage in response to the extracellular pathogen pneumocystis is dependent on MHC class I expression by radiation-resistant lung cells. J Immunol 175(12):8271-9. [PubMed: 16339567]  [MGI Ref ID J:122256]

Messaoudi I; Warner J; Nikolich-Zugich D; Fischer M; Nikolich-Zugich J. 2006. Molecular, cellular, and antigen requirements for development of age-associated T cell clonal expansions in vivo. J Immunol 176(1):301-8. [PubMed: 16365422]  [MGI Ref ID J:126270]

Mishra A; Schlotman J; Wang M; Rothenberg ME. 2007. Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in mice. J Leukoc Biol 81(4):916-24. [PubMed: 17194734]  [MGI Ref ID J:121455]

Miyahara N; Takeda K; Kodama T; Joetham A; Taube C; Park JW; Miyahara S; Balhorn A; Dakhama A; Gelfand EW. 2004. Contribution of antigen-primed CD8(+) T cells to the development of airway hyperresponsiveness and inflammation is associated with IL-13. J Immunol 172(4):2549-58. [PubMed: 14764728]  [MGI Ref ID J:88063]

Miyahara N; Takeda K; Miyahara S; Taube C; Joetham A; Koya T; Matsubara S; Dakhama A; Tager AM; Luster AD; Gelfand EW. 2005. Leukotriene B4 receptor-1 is essential for allergen-mediated recruitment of CD8+ T cells and airway hyperresponsiveness. J Immunol 174(8):4979-84. [PubMed: 15814727]  [MGI Ref ID J:98154]

Moretto M; Durell B; Schwartzman JD; Khan IA. 2001. Gamma delta T cell-deficient mice have a down-regulated CD8+ T cell immune response against Encephalitozoon cuniculi infection. J Immunol 166(12):7389-97. [PubMed: 11390490]  [MGI Ref ID J:123806]

Mott KR; Underhill D; Wechsler SL; Ghiasi H. 2008. Lymphoid-related CD11c+ CD8alpha+ dendritic cells are involved in enhancing herpes simplex virus type 1 latency. J Virol 82(20):9870-9. [PubMed: 18667491]  [MGI Ref ID J:153404]

Murphy TJ; Choileain NN; Zang Y; Mannick JA; Lederer JA. 2005. CD4+CD25+ regulatory T cells control innate immune reactivity after injury. J Immunol 174(5):2957-63. [PubMed: 15728508]  [MGI Ref ID J:97723]

Murray PD; Pavelko KD; Leibowitz J; Lin X; Rodriguez M. 1998. CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis. J Virol 72(9):7320-9. [PubMed: 9696828]  [MGI Ref ID J:92227]

Murthy AK; Li W; Chaganty BK; Kamalakaran S; Guentzel MN; Seshu J; Forsthuber TG; Zhong G; Arulanandam BP. 2011. Tumor Necrosis Factor Alpha Production from CD8+ T Cells Mediates Oviduct Pathological Sequelae following Primary Genital Chlamydia muridarum Infection. Infect Immun 79(7):2928-35. [PubMed: 21536799]  [MGI Ref ID J:173482]

Najafian N; Chitnis T; Salama AD; Zhu B; Benou C; Yuan X; Clarkson MR; Sayegh MH; Khoury SJ. 2003. Regulatory functions of CD8+CD28- T cells in an autoimmune disease model. J Clin Invest 112(7):1037-48. [PubMed: 14523041]  [MGI Ref ID J:85805]

Nakagawa T; Tsuruoka M; Ogura H; Okuyama Y; Arima Y; Hirano T; Murakami M. 2010. IL-6 positively regulates Foxp3+CD8+ T cells in vivo. Int Immunol 22(2):129-39. [PubMed: 20042455]  [MGI Ref ID J:157654]

Nakanishi Y; Lu B; Gerard C; Iwasaki A. 2009. CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help. Nature 462(7272):510-3. [PubMed: 19898495]  [MGI Ref ID J:155104]

Newell KA; He G; Guo Z; Kim O; Szot GL; Rulifson I; Zhou P; Hart J; Thistlethwaite JR; Bluestone JA. 1999. Cutting edge: blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ but not CD8+ T cells. J Immunol 163(5):2358-62. [PubMed: 10452966]  [MGI Ref ID J:57103]

Ngai P; McCormick S; Small C; Zhang X; Zganiacz A; Aoki N; Xing Z. 2007. Gamma interferon responses of CD4 and CD8 T-cell subsets are quantitatively different and independent of each other during pulmonary Mycobacterium bovis BCG infection. Infect Immun 75(5):2244-52. [PubMed: 17307945]  [MGI Ref ID J:121875]

Oakley MS; Majam V; Mahajan B; Gerald N; Anantharaman V; Ward JM; Faucette LJ; McCutchan TF; Zheng H; Terabe M; Berzofsky JA; Aravind L; Kumar S. 2009. Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice. PLoS One 4(8):e6793. [PubMed: 19710907]  [MGI Ref ID J:152399]

Oakley MS; McCutchan TF; Anantharaman V; Ward JM; Faucette L; Erexson C; Mahajan B; Zheng H; Majam V; Aravind L; Kumar S. 2008. Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in mice. Infect Immun 76(10):4518-29. [PubMed: 18644885]  [MGI Ref ID J:140145]

Okamoto M; Takeda K; Joetham A; Ohnishi H; Matsuda H; Swasey CH; Swanson BJ; Yasutomo K; Dakhama A; Gelfand EW. 2008. Essential role of Notch signaling in effector memory CD8+ T cell-mediated airway hyperresponsiveness and inflammation. J Exp Med 205(5):1087-97. [PubMed: 18426985]  [MGI Ref ID J:136299]

Oliveira-dos-Santos AJ; Penninger JM; Rieker-Geley T; Matsumoto G; Mak TM; Wick G. 1998. Thymic heterotypic cellular complexes in gene-targeted mice with defined blocks in T cell development and adhesion molecule expression. Eur J Immunol 28(9):2882-92. [PubMed: 9754575]  [MGI Ref ID J:49877]

Olsson T; Bakhiet M; Hojeberg B; Ljungdahl A; Edlund C; Andersson G; Ekre HP; Fung-Leung WP; Mak T; Wigzell H; et al.. 1993. CD8 is critically involved in lymphocyte activation by a T. brucei brucei-released molecule. Cell 72(5):715-27. [PubMed: 8453666]  [MGI Ref ID J:112991]

Opavsky MA; Penninger J; Aitken K; Wen WH; Dawood F; Mak T; Liu P. 1999. Susceptibility to myocarditis is dependent on the response of alphabeta T lymphocytes to coxsackieviral infection. Circ Res 85(6):551-8. [PubMed: 10488058]  [MGI Ref ID J:114217]

Park JH; Adoro S; Lucas PJ; Sarafova SD; Alag AS; Doan LL; Erman B; Liu X; Ellmeier W; Bosselut R; Feigenbaum L; Singer A. 2007. 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nat Immunol 8(10):1049-59. [PubMed: 17873878]  [MGI Ref ID J:125259]

Pearce EL; Shedlock DJ; Shen H. 2004. Functional characterization of MHC class II-restricted CD8+CD4- and CD8-CD4- T cell responses to infection in CD4-/- mice. J Immunol 173(4):2494-9. [PubMed: 15294964]  [MGI Ref ID J:92690]

Pearson T; Markees TG; Serreze DV; Pierce MA; Marron MP; Wicker LS; Peterson LB; Shultz LD; Mordes JP; Rossini AA; Greiner DL. 2003. Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice. J Immunol 171(1):185-95. [PubMed: 12816997]  [MGI Ref ID J:109845]

Penninger JM; Neu N; Timms E; Wallace VA; Koh DR; Kishihara K; Pummerer C; Mak TW. 1993. The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected] [published erratum appears in J Exp Med 1994 Jan 1;179(1):371] J Exp Med 178(5):1837-42. [PubMed: 8228830]  [MGI Ref ID J:15279]

Penninger JM; Sirard C; Mittrucker HW; Chidgey A; Kozieradzki I; Nghiem M; Hakem A; Kimura T; Timms E; Boyd R; Taniguchi T; Matsuyama T; Mak TW. 1997. The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes. Immunity 7(2):243-54. [PubMed: 9285409]  [MGI Ref ID J:111439]

Petrofsky M; Bermudez LE. 2005. CD4+ T cells but Not CD8+ or gammadelta+ lymphocytes are required for host protection against Mycobacterium avium infection and dissemination through the intestinal route. Infect Immun 73(5):2621-7. [PubMed: 15845464]  [MGI Ref ID J:97613]

Pien GC; Nguyen KB; Malmgaard L; Satoskar AR; Biron CA. 2002. A unique mechanism for innate cytokine promotion of T cell responses to viral infections. J Immunol 169(10):5827-37. [PubMed: 12421964]  [MGI Ref ID J:80075]

Pillai AB; George TI; Dutt S; Strober S. 2009. Host natural killer T cells induce an interleukin-4-dependent expansion of donor CD4+CD25+Foxp3+ T regulatory cells that protects against graft-versus-host disease. Blood 113(18):4458-67. [PubMed: 19221040]  [MGI Ref ID J:148423]

Rabb H; Daniels F; O'Donnell M; Haq M; Saba SR; Keane W; Tang WW. 2000. Pathophysiological role of T lymphocytes in renal ischemia-reperfusion injury in mice. Am J Physiol Renal Physiol 279(3):F525-31. [PubMed: 10966932]  [MGI Ref ID J:114177]

Recher M; Lang KS; Hunziker L; Freigang S; Eschli B; Harris NL; Navarini A; Senn BM; Fink K; Lotscher M; Hangartner L; Zellweger R; Hersberger M; Theocharides A; Hengartner H; Zinkernagel RM. 2004. Deliberate removal of T cell help improves virus-neutralizing antibody production. Nat Immunol 5(9):934-42. [PubMed: 15300247]  [MGI Ref ID J:92168]

Ribas A; Wargo JA; Comin-Anduix B; Sanetti S; Schumacher LY; McLean C; Dissette VB; Glaspy JA; McBride WH; Butterfield LH; Economou JS. 2004. Enhanced tumor responses to dendritic cells in the absence of CD8-positive cells. J Immunol 172(8):4762-9. [PubMed: 15067052]  [MGI Ref ID J:89152]

Riddle DS; Miller PJ; Vincent BG; Kepler TB; Maile R; Frelinger JA; Collins EJ. 2008. Rescue of cytotoxic function in the CD8alpha knockout mouse by removal of MHC class II. Eur J Immunol 38(6):1511-21. [PubMed: 18465769]  [MGI Ref ID J:136196]

Roberts SJ; Ng BY; Filler RB; Lewis J; Glusac EJ; Hayday AC; Tigelaar RE; Girardi M. 2007. Characterizing tumor-promoting T cells in chemically induced cutaneous carcinogenesis. Proc Natl Acad Sci U S A 104(16):6770-5. [PubMed: 17412837]  [MGI Ref ID J:120942]

Rottenberg ME; Bakhiet M; Olsson T; Kristensson K; Mak T; Wigzell H; Orn A. 1993. Differential susceptibilities of mice genomically deleted of CD4 and CD8 to infections with Trypanosoma cruzi or Trypanosoma brucei. Infect Immun 61(12):5129-33. [PubMed: 8225589]  [MGI Ref ID J:111017]

Rottenberg ME; Gigliotti Rothfuchs AC; Gigliotti D; Svanholm C; Bandholtz L; Wigzell H. 1999. Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice. J Immunol 162(5):2829-36. [PubMed: 10072530]  [MGI Ref ID J:124536]

Rottenberg ME; Riarte A; Sporrong L; Altcheh J; Petray P; Ruiz AM; Wigzell H; Orn A. 1995. Outcome of infection with different strains of Trypanosoma cruzi in mice lacking CD4 and/or CD8. Immunol Lett 45(1-2):53-60. [PubMed: 7622189]  [MGI Ref ID J:112349]

Russell MS; Dudani R; Krishnan L; Sad S. 2009. IFN-gamma expressed by T cells regulates the persistence of antigen presentation by limiting the survival of dendritic cells. J Immunol 183(12):7710-8. [PubMed: 19923462]  [MGI Ref ID J:157498]

Ruzek D; Salat J; Singh SK; Kopecky J. 2011. Breakdown of the Blood-Brain Barrier during Tick-Borne Encephalitis in Mice Is Not Dependent on CD8 T-Cells. PLoS One 6(5):e20472. [PubMed: 21629771]  [MGI Ref ID J:172575]

Sardinha LR; Elias RM; Mosca T; Bastos KR; Marinho CR; D'Imperio Lima MR; Alvarez JM. 2006. Contribution of NK, NK T, gammadelta T, and alphabeta T cells to the gamma interferon response required for liver protection against Trypanosoma cruzi. Infect Immun 74(4):2031-42. [PubMed: 16552032]  [MGI Ref ID J:107423]

Sawa S; Kamimura D; Jin GH; Morikawa H; Kamon H; Nishihara M; Ishihara K; Murakami M; Hirano T. 2006. Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. J Exp Med 203(6):1459-70. [PubMed: 16717113]  [MGI Ref ID J:124381]

Schaeffer M; Han SJ; Chtanova T; van Dooren GG; Herzmark P; Chen Y; Roysam B; Striepen B; Robey EA. 2009. Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii. J Immunol 182(10):6379-93. [PubMed: 19414791]  [MGI Ref ID J:148321]

Schilham MW; Fung-Leung WP; Rahemtulla A; Kuendig T; Zhang L; Potter J; Miller RG; Hengartner H; Mak TW. 1993. Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8. Eur J Immunol 23(6):1299-304. [PubMed: 8500525]  [MGI Ref ID J:12572]

Schmidt D; Verdaguer J; Averill N; Santamaria P. 1997. A mechanism for the major histocompatibility complex-linked resistance to autoimmunity. J Exp Med 186(7):1059-75. [PubMed: 9314555]  [MGI Ref ID J:108768]

Semmling V; Lukacs-Kornek V; Thaiss CA; Quast T; Hochheiser K; Panzer U; Rossjohn J; Perlmutter P; Cao J; Godfrey DI; Savage PB; Knolle PA; Kolanus W; Forster I; Kurts C. 2010. Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. Nat Immunol 11(4):313-20. [PubMed: 20190758]  [MGI Ref ID J:158986]

Senaldi G; Shaklee CL; Mak TW; Ulich TR. 1999. Corynebacterium parvum- and Mycobacterium bovis Bacillus Calmette and Guerin-induced granuloma formation in mice lacking CD4 and CD8. Cell Immunol 193(2):155-61. [PubMed: 10222057]  [MGI Ref ID J:114269]

Serpe CJ; Coers S; Sanders VM; Jones KJ. 2003. CD4+ T, but not CD8+ or B, lymphocytes mediate facial motoneuron survival after facial nerve transection. Brain Behav Immun 17(5):393-402. [PubMed: 12946661]  [MGI Ref ID J:105952]

Sherwood ER; Enoh VT; Murphey ED; Lin CY. 2004. Mice depleted of CD8+ T and NK cells are resistant to injury caused by cecal ligation and puncture. Lab Invest 84(12):1655-65. [PubMed: 15448711]  [MGI Ref ID J:110788]

Sherwood ER; Lin CY; Tao W; Hartmann CA; Dujon JE; French AJ; Varma TK. 2003. Beta 2 microglobulin knockout mice are resistant to lethal intraabdominal sepsis. Am J Respir Crit Care Med 167(12):1641-9. [PubMed: 12626348]  [MGI Ref ID J:103038]

Shi FD; Li H; Wang H; Bai X; van der Meide PH; Link H; Ljunggren HG. 1999. Mechanisms of nasal tolerance induction in experimental autoimmune myasthenia gravis: identification of regulatory cells. J Immunol 162(10):5757-63. [PubMed: 10229808]  [MGI Ref ID J:120564]

Singer DS; Zinger H; Kohn LD; Mozes E. 1999. Differing MHC class I requirements for induction and propagation of experimental systemic lupus erythematosus. Eur J Immunol 29(7):2259-68. [PubMed: 10427989]  [MGI Ref ID J:115300]

Stabile E; Kinnaird T; la Sala A; Hanson SK; Watkins C; Campia U; Shou M; Zbinden S; Fuchs S; Kornfeld H; Epstein SE; Burnett MS. 2006. CD8+ T lymphocytes regulate the arteriogenic response to ischemia by infiltrating the site of collateral vessel development and recruiting CD4+ mononuclear cells through the expression of interleukin-16. Circulation 113(1):118-24. [PubMed: 16380545]  [MGI Ref ID J:121521]

Stromberg PE; Woolsey CA; Clark AT; Clark JA; Turnbull IR; McConnell KW; Chang KC; Chung CS; Ayala A; Buchman TG; Hotchkiss RS; Coopersmith CM. 2009. CD4+ lymphocytes control gut epithelial apoptosis and mediate survival in sepsis. FASEB J 23(6):1817-25. [PubMed: 19158156]  [MGI Ref ID J:150554]

Sun K; Metzger DW. 2008. Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection. Nat Med 14(5):558-64. [PubMed: 18438414]  [MGI Ref ID J:136669]

Sun Y; Blink SE; Chen JH; Fu YX. 2005. Regulation of follicular dendritic cell networks by activated T cells: the role of CD137 signaling. J Immunol 175(2):884-90. [PubMed: 16002686]  [MGI Ref ID J:100693]

Swanson KA; Zheng Y; Heidler KM; Zhang ZD; Webb TJ; Wilkes DS. 2004. Flt3-ligand, IL-4, GM-CSF, and adherence-mediated isolation of murine lung dendritic cells: assessment of isolation technique on phenotype and function. J Immunol 173(8):4875-81. [PubMed: 15470028]  [MGI Ref ID J:93713]

Tada Y; Ho A; Koh DR; Mak TW. 1996. Collagen-induced arthritis in CD4- or CD8-deficient mice: CD8+ T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis. J Immunol 156(11):4520-6. [PubMed: 8666829]  [MGI Ref ID J:110669]

Tanchot C; Lemonnier FA; Perarnau B; Freitas AA; Rocha B. 1997. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276(5321):2057-62. [PubMed: 9197272]  [MGI Ref ID J:82165]

Taneja V; Taneja N; Paisansinsup T; Behrens M; Griffiths M; Luthra H; David CS. 2002. CD4 and CD8 T cells in susceptibility/protection to collagen-induced arthritis in HLA-DQ8-transgenic mice: implications for rheumatoid arthritis. J Immunol 168(11):5867-75. [PubMed: 12023391]  [MGI Ref ID J:134936]

Tao J; Gao Y; Li MO; He W; Chen L; Harvev B; Davis RJ; Flavell RA; Yin Z. 2007. JNK2 negatively regulates CD8(+) T cell effector function and anti-tumor immune response. Eur J Immunol 37(3):818-29. [PubMed: 17301952]  [MGI Ref ID J:118685]

Taube C; Miyahara N; Ott V; Swanson B; Takeda K; Loader J; Shultz LD; Tager AM; Luster AD; Dakhama A; Gelfand EW. 2006. The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness. J Immunol 176(5):3157-64. [PubMed: 16493075]  [MGI Ref ID J:129412]

Tilloy F; Treiner E; Park SH; Garcia C; Lemonnier F; de la Salle H; Bendelac A; Bonneville M; Lantz O. 1999. An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammals. J Exp Med 189(12):1907-21. [PubMed: 10377186]  [MGI Ref ID J:55844]

Tumanov AV; Koroleva EP; Christiansen PA; Khan MA; Ruddy MJ; Burnette B; Papa S; Franzoso G; Nedospasov SA; Fu YX; Anders RA. 2009. T cell-derived lymphotoxin regulates liver regeneration. Gastroenterology 136(2):694-704.e4. [PubMed: 18952083]  [MGI Ref ID J:145619]

Tzelepis F; Persechini PM; Rodrigues MM. 2007. Modulation of CD4+ T cell-dependent specific cytotoxic CD8+ T cells differentiation and proliferation by the timing of increase in the pathogen load. PLoS ONE 2(4):e393. [PubMed: 17460760]  [MGI Ref ID J:129273]

Urbieta M; Barao I; Jones M; Jurecic R; Panoskaltsis-Mortari A; Blazar BR; Murphy WJ; Levy RB. 2010. Hematopoietic progenitor cell regulation by CD4+CD25+ T cells. Blood 115(23):4934-43. [PubMed: 20200356]  [MGI Ref ID J:161563]

Urdahl KB; Liggitt D; Bevan MJ. 2003. CD8+ T cells accumulate in the lungs of Mycobacterium tuberculosis-infected Kb-/-Db-/- mice, but provide minimal protection. J Immunol 170(4):1987-94. [PubMed: 12574368]  [MGI Ref ID J:82297]

VanLith ML; Kohlgraf KG; Sivinski CL; Tempero RM; Hollingsworth MA. 2002. MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses. Int Immunol 14(8):873-82. [PubMed: 12147624]  [MGI Ref ID J:113544]

Venet F; Chung CS; Huang X; Lomas-Neira J; Chen Y; Ayala A. 2009. Lymphocytes in the development of lung inflammation: a role for regulatory CD4+ T cells in indirect pulmonary lung injury. J Immunol 183(5):3472-80. [PubMed: 19641139]  [MGI Ref ID J:151875]

Vu MD; Amanullah F; Li Y; Demirci G; Sayegh MH; Li XC. 2004. Different costimulatory and growth factor requirements for CD4+ and CD8+ T cell-mediated rejection. J Immunol 173(1):214-21. [PubMed: 15210777]  [MGI Ref ID J:90930]

Wallace VA; Fung-Leung WP; Timms E; Gray D; Kishihara K; Loh DY; Penninger J; Mak TW. 1992. CD45RA and CD45RBhigh expression induced by thymic selection events. J Exp Med 176(6):1657-63. [PubMed: 1460424]  [MGI Ref ID J:110723]

Wallace VA; Kondo S; Kono T; Xing Z; Timms E; Furlonger C; Keystone E; Gauldie J; Sauder DN; Mak TW; Paige CJ. 1994. A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin mice. Eur J Immunol 24(6):1463-6. [PubMed: 7911425]  [MGI Ref ID J:18913]

Wallace VA; Penninger J; Mak TW. 1994. T-Cell development in CD4, CD8, and p56(lck) Gene-Targeted mice.. In: Transgenesis and Targeted Mutagenesis in Immunology. Academic Press, Inc..  [MGI Ref ID J:21662]

Wang B; Fujisawa H; Zhuang L; Freed I; Howell BG; Shahid S; Shivji GM; Mak TW; Sauder DN. 2000. CD4(+) Th1 and CD8(+) type 1 cytotoxic T cells both play a crucial role in the full development of contact hypersensitivity J Immunol 165(12):6783-90. [PubMed: 11120799]  [MGI Ref ID J:66170]

Wang T; Chen L; Ahmed E; Ma L; Yin D; Zhou P; Shen J; Xu H; Wang CR; Alegre ML; Chong AS. 2008. Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes. J Immunol 180(9):5991-9. [PubMed: 18424719]  [MGI Ref ID J:134678]

Weber SE; Tian H; Pirofski LA. 2011. CD8+ cells enhance resistance to pulmonary serotype 3 Streptococcus pneumoniae infection in mice. J Immunol 186(1):432-42. [PubMed: 21135172]  [MGI Ref ID J:168003]

Wei B; Su TT; Dalwadi H; Stephan RP; Fujiwara D; Huang TT; Brewer S; Chen L; Arditi M; Borneman J; Rawlings DJ; Braun J. 2008. Resident enteric microbiota and CD8(+) T cells shape the abundance of marginal zone B cells. Eur J Immunol 38(12):3411-3425. [PubMed: 19009526]  [MGI Ref ID J:141389]

Wei B; Wingender G; Fujiwara D; Chen DY; McPherson M; Brewer S; Borneman J; Kronenberg M; Braun J. 2010. Commensal microbiota and CD8+ T cells shape the formation of invariant NKT cells. J Immunol 184(3):1218-26. [PubMed: 20048124]  [MGI Ref ID J:159495]

Wen T; Trumper L; Fung-Leung W; Rahemtulla A; Klein E; Klein G; Mak TW. 1998. Requirement of the CD8+ or CD4+ T lymphocyte subsets for the rejection of lymphoma and fibrosarcoma grafts studied in gene knockout hosts. Immunol Lett 61(2-3):187-90. [PubMed: 9657273]  [MGI Ref ID J:47925]

Wesche-Soldato DE; Chung CS; Gregory SH; Salazar-Mather TP; Ayala CA; Ayala A. 2007. CD8+ T cells promote inflammation and apoptosis in the liver after sepsis: role of Fas-FasL. Am J Pathol 171(1):87-96. [PubMed: 17591956]  [MGI Ref ID J:122836]

Wiesel M; Kratky W; Oxenius A. 2011. Type I IFN substitutes for T cell help during viral infections. J Immunol 186(2):754-63. [PubMed: 21160039]  [MGI Ref ID J:168770]

Wolfort RM; Stokes KY; Granger DN. 2008. CD4+ T lymphocytes mediate hypercholesterolemia-induced endothelial dysfunction via a NAD(P)H oxidase-dependent mechanism. Am J Physiol Heart Circ Physiol 294(6):H2619-26. [PubMed: 18408127]  [MGI Ref ID J:136828]

Xiang J; Huang H; Liu Y. 2005. A new dynamic model of CD8+ T effector cell responses via CD4+ T helper-antigen-presenting cells. J Immunol 174(12):7497-505. [PubMed: 15944248]  [MGI Ref ID J:100792]

Xin H; Kikuchi T; Andarini S; Ohkouchi S; Suzuki T; Nukiwa T; Hagiwara K; Honjo T; Saijo Y. 2005. Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells. Eur J Immunol 35(5):1371-80. [PubMed: 15789339]  [MGI Ref ID J:97809]

Xu R; Johnson AJ; Liggitt D; Bevan MJ. 2004. Cellular and humoral immunity against vaccinia virus infection of mice. J Immunol 172(10):6265-71. [PubMed: 15128815]  [MGI Ref ID J:89851]

Yang PL; Althage A; Chung J; Maier H; Wieland S; Isogawa M; Chisari FV. 2010. Immune effectors required for hepatitis B virus clearance. Proc Natl Acad Sci U S A 107(2):798-802. [PubMed: 20080755]  [MGI Ref ID J:156523]

Yuan X; Ansari MJ; D'Addio F; Paez-Cortez J; Schmitt I; Donnarumma M; Boenisch O; Zhao X; Popoola J; Clarkson MR; Yagita H; Akiba H; Freeman GJ; Iacomini J; Turka LA; Glimcher LH; Sayegh MH. 2009. Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proc Natl Acad Sci U S A 106(26):10734-9. [PubMed: 19528638]  [MGI Ref ID J:150842]

Yusuf N; Nasti TH; Katiyar SK; Jacobs MK; Seibert MD; Ginsburg AC; Timares L; Xu H; Elmets CA. 2008. Antagonistic roles of CD4+ and CD8+ T-cells in 7,12-dimethylbenz(a)anthracene cutaneous carcinogenesis. Cancer Res 68(10):3924-30. [PubMed: 18483278]  [MGI Ref ID J:135019]

Zhang B; Zhang Y; Niu L; Vella AT; Mittler RS. 2010. Dendritic cells and Stat3 are essential for CD137-induced CD8 T cell activation-induced cell death. J Immunol 184(9):4770-8. [PubMed: 20351189]  [MGI Ref ID J:160463]

Zhang GX; Xiao BG; Bakhiet M; van der Meide P; Wigzell H; Link H; Olsson T. 1996. Both CD4+ and CD8+ T cells are essential to induce experimental autoimmune myasthenia gravis. J Exp Med 184(2):349-56. [PubMed: 8760788]  [MGI Ref ID J:110750]

Zhang S; Bernard D; Khan WI; Kaplan MH; Bramson JL; Wan Y. 2009. CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis. Eur J Immunol 39(5):1252-9. [PubMed: 19338001]  [MGI Ref ID J:148099]

Zhang XL; Zhao S; Borenstein SH; Liu Y; Jayabalasingham B; Chamberlain JW. 2001. CD8 expression up to the double-positive CD3(low/intermediate) stage of thymic differentiation is sufficient for development of peripheral functional cytotoxic T lymphocytes. J Exp Med 194(5):685-93. [PubMed: 11535636]  [MGI Ref ID J:71351]

Zhou S; Kurt-Jones EA; Cerny AM; Chan M; Bronson RT; Finberg RW. 2009. MyD88 intrinsically regulates CD4 T-cell responses. J Virol 83(4):1625-34. [PubMed: 19052080]  [MGI Ref ID J:153385]

Zhu Y; Bao L; Zhu S; Chen Z; van der Meide P; Nennesmo I; Winblad B; Ljunggren HG; Zhu J. 2002. CD4 and CD8 T cells, but not B cells, are critical to the control of murine experimental autoimmune neuritis. Exp Neurol 177(1):314-20. [PubMed: 12429233]  [MGI Ref ID J:118779]

de Visser KE; Korets LV; Coussens LM. 2005. De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell 7(5):411-23. [PubMed: 15894262]  [MGI Ref ID J:98942]

van den Broek ME; Kagi D; Ossendorp F; Toes R; Vamvakas S; Lutz WK ; Melief CJ ; Zinkernagel RM ; Hengartner H. 1996. Decreased tumor surveillance in perforin-deficient mice. J Exp Med 184(5):1781-90. [PubMed: 8920866]  [MGI Ref ID J:36584]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.

Colony Maintenance

Diet Information	LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls

General Supply Notes

• This strain is included in the Induced Mutant Resource Colony collection.

Control Information

	Control
	101045 B6129SF2/J	(approximate)
Considerations for Choosing Controls
Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

---

Ordering Information
JAX^® Mice
Surgical and Preconditioning Services
JAX^® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Strain(s) not available to companies or for-profit entities.

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.