Description

Strain Information

Former Names B6.129P2-Agtr1atm1Unc    (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote         (Female x Male) Species laboratory mouse Background Strain C57BL/6 Donor Strain 129P2 via E14TG2a ES cell line Generation N9+1F7 (22-DEC-08)   Donating Investigator Oliver Smithies,   University of North Carolina

Appearance
black
Related Genotype: a/a

Description
Mice homozygous mice for the targeted mutation are viable and fertile. Pressor responses to angiotensin II infusions are absent and blood pressure levels are ~24 mmHg lower than normal wildtype siblings. Heterozygous mice have blood pressure levels ~12 mmHg lower than normal wildtype siblings and show qualitatively altered responses to angiotensin II infusions.

Development
Coding sequences from the emdogenous gene were disrupted by insertion of a neomycin resistance gene construct. The targeting construct was electroporated into 129P2/OlaHsd-derived BK4 (E14TG2a clone)embryonic stem (ES) cells. Correctly targeted ES cells were injected into blastocysts. Chimeric males were bred with C57BL/6J females. This mutant was backcrossed to C57BL/6 at least seven generations.

Control Information

	Control
	000664 C57BL/6J
Considerations for Choosing Controls

Additional Web Information

Congenic Nomenclature

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

Agtr1a^tm1Unc/Agtr1a⁺

        involves: 129P2/OlaHsd * C57BL/6J

• cardiovascular system phenotype
• abnormal blood pressure (MGI Ref ID J:24354)
  • pressure responses to angiotensin II administration are short lived compared to wild-type
• decreased blood pressure (MGI Ref ID J:24354)
  • arterial pressure measured by carotid cannula is reduced by 17 mmHg
• decreased systolic blood pressure (MGI Ref ID J:24354)
  • systolic blood pressure measured by tail cuff sphygmomanometer is reduced by 12 mmHg

Agtr1a^tm1Unc/Agtr1a^tm1Unc

        involves: 129P2/OlaHsd * C57BL/6J

• cardiovascular system phenotype
• abnormal blood pressure (MGI Ref ID J:24354)
  • loss of pressure responses to angiotensin II administration
• decreased blood pressure (MGI Ref ID J:24354)
  • arterial pressure measured by carotid cannula is reduced by 43 mmHg, however homozygotes appear to have a normal heart, kidney and vascular system
• decreased systolic blood pressure (MGI Ref ID J:24354)
  • systolic blood pressure measured by tail cuff sphygmomanometer is reduced by 24 mmHg

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Agtr1a^tm1Unc related

Cardiovascular Research
Hypotension

Genes & Alleles

Gene & Allele Information

Allele Symbol		Agtr1atm1Unc
Allele Name		targeted mutation 1, University of North Carolina
Allele Type		Targeted (knock-out)
Common Name(s)		AT1-R-; AT1A-KO; AT1AR KO; AT1aR-; Agrt1tm1Unc; Agtr1A-; At1A-;
Strain of Origin		129P2/OlaHsd
ES Cell Line Name		E14TG2a
ES Cell Line Strain		129P2/OlaHsd
Gene Symbol and Name		Agtr1a, angiotensin II receptor, type 1a
Chromosome		13
Gene Common Name(s)		1810074K20Rik; AG2S; AGTR1B; AI551199; AT1; AT1A; AT1B; AT1R; AT2R1; AT2R1A; AT2R1B; Agtr-1a; Angtr-1a; HAT1R; MGC:37610; RIKEN cDNA 1810074K20 gene; andiotensin receptor 1a; angiotensin receptor 1a; expressed sequence AI551199;
General Note		Kidneys of these null receptor mice are normal except for some expansion of renin-producing cells (J:45507).
Molecular Note		A 0.5kb genomic fragment containing part of the coding sequences of the gene was replaced with a neomycin selection cassette. Binding studies in kidney indicated that no functional protein was detectable in homozygous mice. [MGI Ref ID J:24354]

Genotyping

Genotyping Information

Genotyping Protocols

Agtr1a^tm1Unc, STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Ito M; Oliverio MI; Mannon PJ; Best CF; Maeda N; Smithies O; Coffman TM. 1995. Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc Natl Acad Sci U S A 92(8):3521-5. [PubMed: 7724593]  [MGI Ref ID J:24354]

Additional References

Agtr1a^tm1Unc related

Bridgman P; Aronovitz MA; Kakkar R; Oliverio MI; Coffman TM; Rand WM; Konstam MA; Mendelsohn ME; Patten RD. 2005. Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor. Am J Physiol Heart Circ Physiol 289(2):H586-92. [PubMed: 15764682]  [MGI Ref ID J:100321]

Cassis LA; Rateri DL; Lu H; Daugherty A. 2007. Bone marrow transplantation reveals that recipient AT1a receptors are required to initiate angiotensin II-induced atherosclerosis and aneurysms. Arterioscler Thromb Vasc Biol 27(2):380-6. [PubMed: 17158350]  [MGI Ref ID J:130546]

Cervenka L; Horacek V; Vaneckova I; Hubacek JA; Oliverio MI; Coffman TM; Navar LG. 2002. Essential role of AT1A receptor in the development of 2K1C hypertension. Hypertension 40(5):735-41. [PubMed: 12411470]  [MGI Ref ID J:103260]

Cervenka L; Mitchell KD; Oliverio MI; Coffman TM; Navar LG. 1999. Renal function in the AT1A receptor knockout mouse during normal and volume-expanded conditions. Kidney Int 56(5):1855-62. [PubMed: 10571794]  [MGI Ref ID J:59646]

Chen Y; Chen H; Morris M. 2005. Enhanced osmotic responsiveness in angiotensin AT1a receptor deficient mice: evidence for a role for AT1b receptors. Exp Physiol 90(5):739-46. [PubMed: 15944203]  [MGI Ref ID J:112501]

Chen Y; Joaquim LF; Farah VM; Wichi RB; Fazan R Jr; Salgado HC; Morris M. 2005. Cardiovascular autonomic control in mice lacking angiotensin AT1a receptors. Am J Physiol Regul Integr Comp Physiol 288(4):R1071-7. [PubMed: 15576667]  [MGI Ref ID J:97196]

Chen Y; Oroszi TL; Morris M. 2006. Salt consumption increases blood pressure and abolishes the light/dark rhythm in angiotensin AT1a receptor deficient mice. Physiol Behav 88(1-2):95-100. [PubMed: 16643970]  [MGI Ref ID J:112773]

Crowley SD; Gurley SB; Herrera MJ; Ruiz P; Griffiths R; Kumar AP; Kim HS; Smithies O; Le TH; Coffman TM. 2006. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A 103(47):17985-90. [PubMed: 17090678]  [MGI Ref ID J:117124]

Crowley SD; Gurley SB; Oliverio MI; Pazmino AK; Griffiths R; Flannery PJ; Spurney RF; Kim HS; Smithies O; Le TH; Coffman TM. 2005. Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. J Clin Invest 115(4):1092-9. [PubMed: 15841186]  [MGI Ref ID J:97377]

Davisson RL. 2003. Physiological genomic analysis of the brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol 285(3):R498-511. [PubMed: 12909574]  [MGI Ref ID J:85403]

Davisson RL; Oliverio MI; Coffman TM; Sigmund CD. 2000. Divergent functions of angiotensin II receptor isoforms in the brain. J Clin Invest 106(1):103-6. [PubMed: 10880053]  [MGI Ref ID J:103184]

Farah V; Elased KM; Morris M. 2007. Genetic and dietary interactions: role of angiotensin AT1a receptors in response to a high-fructose diet. Am J Physiol Heart Circ Physiol 293(2):H1083-9. [PubMed: 17449556]  [MGI Ref ID J:126047]

Gembardt F; Heringer-Walther S; van Esch JH; Sterner-Kock A; van Veghel R; Le TH; Garrelds IM; Coffman TM; Danser AH; Schultheiss HP; Walther T. 2008. Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors. FASEB J 22(8):3068-77. [PubMed: 18497303]  [MGI Ref ID J:137944]

Guzik TJ; Hoch NE; Brown KA; McCann LA; Rahman A; Dikalov S; Goronzy J; Weyand C; Harrison DG. 2007. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med 204(10):2449-60. [PubMed: 17875676]  [MGI Ref ID J:126052]

Harrison-Bernard LM; Cook AK; Oliverio MI; Coffman TM. 2003. Renal segmental microvascular responses to ANG II in AT1A receptor null mice. Am J Physiol Renal Physiol 284(3):F538-45. [PubMed: 12429556]  [MGI Ref ID J:113616]

Harrison-Bernard LM; Monjure CJ; Bivona BJ. 2006. Efferent arterioles exclusively express the subtype 1A angiotensin receptor: functional insights from genetic mouse models. Am J Physiol Renal Physiol 290(5):F1177-86. [PubMed: 16332932]  [MGI Ref ID J:108372]

Huang F; Thompson JC; Wilson PG; Aung HH; Rutledge JC; Tannock LR. 2008. Angiotensin II increases vascular proteoglycan content preceding and contributing to atherosclerosis development. J Lipid Res 49(3):521-30. [PubMed: 18033753]  [MGI Ref ID J:133289]

Ihara Y; Egashira K; Nakano K; Ohtani K; Kubo M; Koga J; Iwai M; Horiuchi M; Gang Z; Yamagishi S; Sunagawa K. 2007. Upregulation of the ligand-RAGE pathway via the angiotensin II type I receptor is essential in the pathogenesis of diabetic atherosclerosis. J Mol Cell Cardiol 43(4):455-64. [PubMed: 17761193]  [MGI Ref ID J:126372]

Le TH; Fogo AB; Salzler HR; Vinogradova T; Oliverio MI; Marchuk DA; Coffman TM. 2004. Modifier locus on mouse chromosome 3 for renal vascular pathology in AT1A receptor-deficiency. Hypertension 43(2):445-51. [PubMed: 14718357]  [MGI Ref ID J:87921]

Le TH; Oliverio MI; Kim HS; Salzler H; Dash RC; Howell DN; Smithies O; Bronson S; Coffman TM. 2004. A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice. Physiol Genomics 18(3):290-8. [PubMed: 15306694]  [MGI Ref ID J:91837]

Li X; Rayford H; Uhal BD. 2003. Essential roles for angiotensin receptor AT1a in bleomycin-induced apoptosis and lung fibrosis in mice. Am J Pathol 163(6):2523-30. [PubMed: 14633624]  [MGI Ref ID J:86601]

Li XC; Navar LG; Shao Y; Zhuo JL. 2007. Genetic deletion of AT1a receptors attenuates intracellular accumulation of ANG II in the kidney of AT1a receptor-deficient mice. Am J Physiol Renal Physiol 293(2):F586-93. [PubMed: 17537986]  [MGI Ref ID J:123212]

Li XC; Zhuo JL. 2008. In vivo regulation of AT1a receptor-mediated intracellular uptake of [125I]Val5-ANG II in the kidneys and adrenals of AT1a receptor-deficient mice. Am J Physiol Renal Physiol 294(2):F293-302. [PubMed: 18045833]  [MGI Ref ID J:130382]

Lu H; Boustany-Kari CM; Daugherty A; Cassis LA. 2007. Angiotensin II increases adipose angiotensinogen expression. Am J Physiol Endocrinol Metab 292(5):E1280-7. [PubMed: 17213477]  [MGI Ref ID J:121237]

Lu H; Rateri DL; Feldman DL; Jr RJ; Fukamizu A; Ishida J; Oesterling EG; Cassis LA; Daugherty A. 2008. Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice. J Clin Invest 118(3):984-93. [PubMed: 18274671]  [MGI Ref ID J:135297]

Mangrum AJ; Gomez RA; Norwood VF. 2002. Effects of AT(1A) receptor deletion on blood pressure and sodium excretion during altered dietary salt intake. Am J Physiol Renal Physiol 283(3):F447-53. [PubMed: 12167595]  [MGI Ref ID J:78903]

Matsusaka T; Fogo A; Ichikawa I. 1997. Targeting the genes of angiotensin receptors. Semin Nephrol 17(5):396-403. [PubMed: 9316207]  [MGI Ref ID J:78469]

Maul B; Krause W; Pankow K; Becker M; Gembardt F; Alenina N; Walther T; Bader M; Siems WE. 2005. Central angiotensin II controls alcohol consumption via its AT1 receptor. FASEB J 19(11):1474-81. [PubMed: 16126915]  [MGI Ref ID J:101196]

Mistlberger RE; Antle MC; Oliverio MI; Coffman TM; Morris M. 2001. Circadian rhythms of activity and drinking in mice lacking angiotensin II 1A receptors. Physiol Behav 74(4-5):457-64. [PubMed: 11790405]  [MGI Ref ID J:96352]

Morris M; Li P; Callahan MF; Oliverio MI; Coffman TM; Bosch SM; Diz DI. 1999. Neuroendocrine effects of dehydration in mice lacking the angiotensin AT1a receptor. Hypertension 33(1 Pt 2):482-6. [PubMed: 9931152]  [MGI Ref ID J:103310]

Morris M; Means S; Oliverio MI; Coffman TM. 2001. Enhanced central response to dehydration in mice lacking angiotensin AT(1a) receptors. Am J Physiol Regul Integr Comp Physiol 280(4):R1177-84. [PubMed: 11247842]  [MGI Ref ID J:68658]

Nataraj C; Oliverio MI; Mannon RB; Mannon PJ; Audoly LP; Amuchastegui CS; Ruiz P; Smithies O; Coffman TM. 1999. Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway. J Clin Invest 104(12):1693-701. [PubMed: 10606623]  [MGI Ref ID J:59053]

Oliverio MI; Best CF; Kim HS; Arendshorst WJ; Smithies O; Coffman TM. 1997. Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation. Am J Physiol 272(4 Pt 2):F515-20. [PubMed: 9140053]  [MGI Ref ID J:40261]

Oliverio MI; Best CF; Smithies O; Coffman TM. 2000. Regulation of sodium balance and blood pressure by the AT(1A) receptor for angiotensin II. Hypertension 35(2):550-4. [PubMed: 10679496]  [MGI Ref ID J:103283]

Oliverio MI; Delnomdedieu M; Best CF; Li P; Morris M; Callahan MF; Johnson GA; Smithies O; Coffman TM. 2000. Abnormal water metabolism in mice lacking the type 1A receptor for ANG II. Am J Physiol Renal Physiol 278(1):F75-82. [PubMed: 10644657]  [MGI Ref ID J:59919]

Oliverio MI; Kim HS; Ito M; Le T; Audoly L; Best CF; Hiller S; Kluckman K; Maeda N; Smithies O; Coffman TM. 1998. Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. Proc Natl Acad Sci U S A 95(26):15496-501. [PubMed: 9860997]  [MGI Ref ID J:51667]

Oliverio MI; Madsen K; Best CF; Ito M; Maeda N; Smithies O; Coffman TM. 1998. Renal growth and development in mice lacking AT1A receptors for angiotensin II. Am J Physiol 274(1 Pt 2):F43-50. [PubMed: 9458822]  [MGI Ref ID J:45507]

Oudit GY; Crackower MA; Backx PH; Penninger JM. 2003. The Role of ACE2 in Cardiovascular Physiology. Trends Cardiovasc Med 13(3):93-101. [PubMed: 12691672]  [MGI Ref ID J:83218]

Ouyang X; Le TH; Roncal C; Gersch C; Herrera-Acosta J; Rodriguez-Iturbe B; Coffman TM; Johnson RJ; Mu W. 2005. Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout mice. Am J Physiol Renal Physiol 289(4):F902-10. [PubMed: 15928210]  [MGI Ref ID J:101239]

Park S; Bivona BJ; Harrison-Bernard LM. 2007. Compromised renal microvascular reactivity of angiotensin type 1 double null mice. Am J Physiol Renal Physiol 293(1):F60-7. [PubMed: 17409281]  [MGI Ref ID J:122839]

Park S; Harrison-Bernard LM. 2008. Augmented renal vascular nNOS and renin protein expression in angiotensin type 1 receptor null mice. J Histochem Cytochem 56(4):401-14. [PubMed: 18180383]  [MGI Ref ID J:135356]

Petnehazy T; Cooper D; Stokes KY; Russell J; Wood KC; Granger DN. 2006. Angiotensin II type 1 receptors and the intestinal microvascular dysfunction induced by ischemia and reperfusion. Am J Physiol Gastrointest Liver Physiol 290(6):G1203-10. [PubMed: 16469824]  [MGI Ref ID J:111088]

Petnehazy T; Stokes KY; Wood KC; Russell J; Granger DN. 2006. Role of blood cell-associated AT1 receptors in the microvascular responses to hypercholesterolemia. Arterioscler Thromb Vasc Biol 26(2):313-8. [PubMed: 16254200]  [MGI Ref ID J:127964]

Rajagopal K; Whalen EJ; Violin JD; Stiber JA; Rosenberg PB; Premont RT; Coffman TM; Rockman HA; Lefkowitz RJ. 2006. Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. Proc Natl Acad Sci U S A 103(44):16284-9. [PubMed: 17060617]  [MGI Ref ID J:115598]

Rocha MJ; Chen Y; Oliveira GR; Morris M. 2005. Physiological regulation of brain angiotensin receptor mRNA in AT1a deficient mice. Exp Neurol 195(1):229-35. [PubMed: 16023638]  [MGI Ref ID J:100937]

Ruan X; Oliverio MI; Coffman TM; Arendshorst WJ. 1999. Renal vascular reactivity in mice: AngII-induced vasoconstriction in AT1A receptor null mice. J Am Soc Nephrol 10(12):2620-30. [PubMed: 10589703]  [MGI Ref ID J:59837]

Ryan MJ; Didion SP; Mathur S; Faraci FM; Sigmund CD. 2004. Angiotensin II-induced vascular dysfunction is mediated by the AT1A receptor in mice. Hypertension 43(5):1074-9. [PubMed: 15007032]  [MGI Ref ID J:102336]

Schnermann J. 1999. Micropuncture analysis of tubuloglomerular feedback regulation in transgenic mice. J Am Soc Nephrol 10(12):2614-9. [PubMed: 10589702]  [MGI Ref ID J:59838]

Sun Z; Wang X; Wood CE; Cade JR. 2005. Genetic AT1A receptor deficiency attenuates cold-induced hypertension. Am J Physiol Regul Integr Comp Physiol 288(2):R433-9. [PubMed: 15498966]  [MGI Ref ID J:95793]

Voros S; Yang Z; Bove CM; Gilson WD; Epstein FH; French BA; Berr SS; Bishop SP; Conaway MR; Matsubara H; Carey RM; Kramer CM. 2006. Interaction between AT1 and AT2 receptors during postinfarction left ventricular remodeling. Am J Physiol Heart Circ Physiol 290(3):H1004-10. [PubMed: 16214839]  [MGI Ref ID J:106718]

Walther T; Klostermann K; Heringer-Walther S; Schultheiss HP; Tschope C; Stepan H. 2003. Fibrosis rather than blood pressure determines cardiac BNP expression in mice. Regul Pept 116(1-3):95-100. [PubMed: 14599720]  [MGI Ref ID J:102437]

Walther T; Olah L; Harms C; Maul B; Bader M; Hortnagl H; Schultheiss HP; Mies G. 2002. Ischemic injury in experimental stroke depends on angiotensin II. FASEB J 16(2):169-76. [PubMed: 11818364]  [MGI Ref ID J:74279]

Wassmann S; Czech T; van Eickels M; Fleming I; Bohm M; Nickenig G. 2004. Inhibition of diet-induced atherosclerosis and endothelial dysfunction in apolipoprotein E/angiotensin II type 1A receptor double-knockout mice. Circulation 110(19):3062-7. [PubMed: 15277329]  [MGI Ref ID J:103721]

Wassmann S; Stumpf M; Strehlow K; Schmid A; Schieffer B; Bohm M; Nickenig G. 2004. Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptor. Circ Res 94(4):534-41. [PubMed: 14699015]  [MGI Ref ID J:96664]

Yang T; Endo Y; Huang YG; Smart A; Briggs JP; Schnermann J. 2000. Renin expression in COX-2-knockout mice on normal or low-salt diets. Am J Physiol Renal Physiol 279(5):F819-25. [PubMed: 11053041]  [MGI Ref ID J:114184]

Zhou Y; Chen Y; Dirksen WP; Morris M; Periasamy M. 2003. AT1b receptor predominantly mediates contractions in major mouse blood vessels. Circ Res 93(11):1089-94. [PubMed: 14563714]  [MGI Ref ID J:115664]

Zhou Y; Dirksen WP; Chen Y; Morris M; Zweier JL; Periasamy M. 2005. A major role for AT1b receptor in mouse mesenteric resistance vessels and its distribution in heart and neuroendocrine tissues. J Mol Cell Cardiol 38(4):693-6. [PubMed: 15808846]  [MGI Ref ID J:102132]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB29

Colony Maintenance

Breeding & Husbandry	When maintaining a live colony, homozygous mice are bred. Expected coat color from breeding: Black.
Mating System	Homozygote x Homozygote         (Female x Male)
Diet Information	LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.

Supply Notes

Usually shipped between four and eight weeks of age. This strain is included in the Induced Mutant Resource Colony collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	000664 C57BL/6J
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

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In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.