Strain Name:

B6.129S1-Il12atm1Jm/J

Stock Number:

002692

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Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use
These knock-out mice fail to show any delayed-type hypersensitivity (DTH) reaction, and may be useful in studying resistance to infection.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
Background Strain C57BL/6
Donor Strain 129S1 via W9.5 ES (+Kitl-SlJ) cell line
GenerationN11F43 (06-JAN-09)
Generation Definitions
 
Donating InvestigatorDr. Jeanne Magram,   Boehringer Ingelheim Pharmaceuticals,Inc

Appearance
black
Related Genotype: a/a

Description
Mice homozygous for the Il12atm1Jm targeted mutation on a normally resistant 129/Sv genetic background are unable to restrict the progression of Leishmania major infection, demonstrating the importance of this cytokine for developing such resistance. Homozygotes are unable to mount a delayed-type hypersensitivity (DTH) reaction but a TH2 response is induced. Also known as p35. Please refer to the Il12b-deficient related targeted mutations (Stock No. 002693 and 002694).

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Development
The targeting strategy removed exons 1 and 2 from the Il12a gene.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Il12atm1Jm allele
002691   C.129S1(B6)-Il12atm1Jm/J
View Strains carrying   Il12atm1Jm     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Il12atm1Jm/Il12atm1Jm

        B6.129S1-Il12atm1Jm/J
  • mortality/aging
  • increased sensitivity to xenobiotic induced morbidity/mortality
    • increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls   (MGI Ref ID J:91927)
  • tumorigenesis
  • increased incidence of tumors by chemical induction
    • earlier tumor appearance and increased incidence of papillomas compared to wild-type mice after treatment with DMBA and TPA in a 2 step skin carcinogenesis protocol   (MGI Ref ID J:111568)
    • however, resistance to tumor formation following intradermal challenge with with PDV squamous carcinoma cells is similar to wild-type mice   (MGI Ref ID J:111568)
  • homeostasis/metabolism phenotype
  • increased incidence of tumors by chemical induction
    • earlier tumor appearance and increased incidence of papillomas compared to wild-type mice after treatment with DMBA and TPA in a 2 step skin carcinogenesis protocol   (MGI Ref ID J:111568)
    • however, resistance to tumor formation following intradermal challenge with with PDV squamous carcinoma cells is similar to wild-type mice   (MGI Ref ID J:111568)
  • increased sensitivity to xenobiotic induced morbidity/mortality
    • increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls   (MGI Ref ID J:91927)

Il12atm1Jm/Il12atm1Jm

        B6.129S1-Il12atm1Jm
  • immune system phenotype
  • *normal* immune system phenotype
    • no abnormal response to infection is detected   (MGI Ref ID J:120806)

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Il12atm1Jm/Il12atm1Jm

        129S1/Sv-Il12atm1Jm
  • immune system phenotype
  • abnormal CD4-positive T cell physiology
    • 75 days after infection Il4 mRNA expression in CD4+ cells is 100-fold higher than in wild-type   (MGI Ref ID J:34164)
    • 75 days after infection Ifng mRNA expression in CD4+ cells is more than 50-fold lower than in wild-type   (MGI Ref ID J:34164)
    • draining lymph node cells in L. major infected mice produce significantly more IL4 compared to IFNG in contrast to wild-type mice which express more IFNG than IL4   (MGI Ref ID J:34164)
  • decreased susceptibility to type IV hypersensitivity reaction
    • do not show any delayed type hypersensitivity response to application of Leishmania antigen to the uninfected footpad 41 days after initial infection with L. major   (MGI Ref ID J:34164)
  • increased susceptibility to parasitic infection
    • develop large lesions unlike wild-type 129S1/Sv mice after infection with Leishmania major   (MGI Ref ID J:34164)
    • 75 days after infection with L. major parasite numbers in the draining lymph nodes are increased 80-fold compared to wild-type mice   (MGI Ref ID J:34164)
  • hematopoietic system phenotype
  • abnormal CD4-positive T cell physiology
    • 75 days after infection Il4 mRNA expression in CD4+ cells is 100-fold higher than in wild-type   (MGI Ref ID J:34164)
    • 75 days after infection Ifng mRNA expression in CD4+ cells is more than 50-fold lower than in wild-type   (MGI Ref ID J:34164)
    • draining lymph node cells in L. major infected mice produce significantly more IL4 compared to IFNG in contrast to wild-type mice which express more IFNG than IL4   (MGI Ref ID J:34164)

Il12atm1Jm/Il12atm1Jm

        C.129S1-Il12atm1Jm
  • immune system phenotype
  • impaired natural killer cell mediated cytotoxicity
    • following infection with Leishmania infantum   (MGI Ref ID J:125611)
  • hematopoietic system phenotype
  • impaired natural killer cell mediated cytotoxicity
    • following infection with Leishmania infantum   (MGI Ref ID J:125611)

Il12atm1Jm/Il12atm1Jm

        involves: 129S1/Sv
  • immune system phenotype
  • abnormal NK cell physiology
    • NK cells in vivo make much about 7-fold less IFN-gamma in response to injections of the TLR9 agonist CpG   (MGI Ref ID J:139001)
  • hematopoietic system phenotype
  • abnormal NK cell physiology
    • NK cells in vivo make much about 7-fold less IFN-gamma in response to injections of the TLR9 agonist CpG   (MGI Ref ID J:139001)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Il12atm1Jm related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Il12atm1Jm
Allele Name targeted mutation 1, Jeanne Magram
Allele Type Targeted (knock-out)
Common Name(s) IL-12p35; IL-12p35-; Il12a-; Il12p35-; p35-;
Mutation Made ByDr. Jeanne Magram,   Boehringer Ingelheim Pharmaceuticals,Inc
Strain of Origin129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
ES Cell Line NameW9.5/W95
ES Cell Line Strain129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Gene Symbol and Name Il12a, interleukin 12a
Chromosome 3
Gene Common Name(s) CLMF; IL-12A; IL-12p35; Il-12a; NFSK; NKSF1; P35;
Molecular Note A neomycin resistance cassette replaced exons 1 and 2 of the gene. [MGI Ref ID J:34164]

Genotyping

Genotyping Information

Genotyping Protocols

Il12atm1Jm,

SEPARATED MELT


Il12atm1Jm, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Mattner F; Magram J; Ferrante J; Launois P; Di Padova K; Behin R; Gately MK; Louis JA; Alber G. 1996. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur J Immunol 26(7):1553-9. [PubMed: 8766560]  [MGI Ref ID J:34164]

Additional References

Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. [PubMed: 15153508]  [MGI Ref ID J:90518]

Cua DJ; Sherlock J; Chen Y; Murphy CA; Joyce B; Seymour B; Lucian L; To W; Kwan S; Churakova T; Zurawski S; Wiekowski M; Lira SA; Gorman D; Kastelein RA; Sedgwick JD. 2003. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421(6924):744-8. [PubMed: 12610626]  [MGI Ref ID J:89968]

Hazlett LD; Rudner XL; McClellan SA; Barrett RP; Lighvani S. 2002. Role of IL-12 and IFN-gamma in Pseudomonas aeruginosa corneal infection. Invest Ophthalmol Vis Sci 43(2):419-24. [PubMed: 11818386]  [MGI Ref ID J:74264]

Il12atm1Jm related

Awoniyi M; Miller SI; Wilson CB; Hajjar AM; Smith KD. 2012. Homeostatic regulation of Salmonella-induced mucosal inflammation and injury by IL-23. PLoS One 7(5):e37311. [PubMed: 22624013]  [MGI Ref ID J:187224]

Baird JR; Byrne KT; Lizotte PH; Toraya-Brown S; Scarlett UK; Alexander MP; Sheen MR; Fox BA; Bzik DJ; Bosenberg M; Mullins DW; Turk MJ; Fiering S. 2013. Immune-Mediated Regression of Established B16F10 Melanoma by Intratumoral Injection of Attenuated Toxoplasma gondii Protects against Rechallenge. J Immunol 190(1):469-78. [PubMed: 23225891]  [MGI Ref ID J:190812]

Baird JR; Fox BA; Sanders KL; Lizotte PH; Cubillos-Ruiz JR; Scarlett UK; Rutkowski MR; Conejo-Garcia JR; Fiering S; Bzik DJ. 2013. Avirulent Toxoplasma gondii Generates Therapeutic Antitumor Immunity by Reversing Immunosuppression in the Ovarian Cancer Microenvironment. Cancer Res 73(13):3842-51. [PubMed: 23704211]  [MGI Ref ID J:199114]

Ballas ZK; Buchta CM; Rosean TR; Heusel JW; Shey MR. 2013. Role of NK cell subsets in organ-specific murine melanoma metastasis. PLoS One 8(6):e65599. [PubMed: 23776508]  [MGI Ref ID J:204234]

Barkhuizen M; Magez S; Atkinson RA; Brombacher F. 2007. Interleukin-12p70-dependent interferon- gamma production is crucial for resistance in African trypanosomiasis. J Infect Dis 196(8):1253-60. [PubMed: 17955445]  [MGI Ref ID J:145097]

Becher B; Durell BG; Noelle RJ. 2002. Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J Clin Invest 110(4):493-7. [PubMed: 12189243]  [MGI Ref ID J:78574]

Birkner K; Steiner B; Rinkler C; Kern Y; Aichele P; Bogdan C; von Loewenich FD. 2008. The elimination of Anaplasma phagocytophilum requires CD4(+) T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms. Eur J Immunol 38(12):3395-3410. [PubMed: 19039769]  [MGI Ref ID J:141369]

Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. [PubMed: 15153508]  [MGI Ref ID J:90518]

Bitsaktsis C; Nandi B; Racine R; MacNamara KC; Winslow G. 2007. T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection. Infect Immun 75(10):4933-41. [PubMed: 17664264]  [MGI Ref ID J:125283]

Brigl M; Tatituri RV; Watts GF; Bhowruth V; Leadbetter EA; Barton N; Cohen NR; Hsu FF; Besra GS; Brenner MB. 2011. Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection. J Exp Med 208(6):1163-77. [PubMed: 21555485]  [MGI Ref ID J:177293]

Brombacher F; Dorfmuller A; Magram J; Dai WJ; Kohler G; Wunderlin A; Palmer-Lehmann K; Gately MK; Alber G. 1999. IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes. Int Immunol 11(3):325-32. [PubMed: 10221644]  [MGI Ref ID J:110544]

Camoglio L; Juffermans NP; Peppelenbosch M; te Velde AA; ten Kate FJ; van Deventer SJ; Kopf M. 2002. Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis. Eur J Immunol 32(1):261-9. [PubMed: 11782017]  [MGI Ref ID J:73931]

Chackerian AA; Chen SJ; Brodie SJ; Mattson JD; McClanahan TK; Kastelein RA; Bowman EP. 2006. Neutralization or absence of the interleukin-23 pathway does not compromise immunity to mycobacterial infection. Infect Immun 74(11):6092-9. [PubMed: 16923792]  [MGI Ref ID J:113448]

Chan YR; Liu JS; Pociask DA; Zheng M; Mietzner TA; Berger T; Mak TW; Clifton MC; Strong RK; Ray P; Kolls JK. 2009. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J Immunol 182(8):4947-56. [PubMed: 19342674]  [MGI Ref ID J:147498]

Chang JT; Shevach EM; Segal BM. 1999. Regulation of interleukin (IL)-12 receptor beta2 subunit expression by endogenous IL-12: a critical step in the differentiation of pathogenic autoreactive T cells. J Exp Med 189(6):969-78. [PubMed: 10075980]  [MGI Ref ID J:53619]

Chang SR; Wang KJ; Lu YF; Yang LJ; Chen WJ; Lin YH; Chang HH; Wang SL. 2007. Characterization of Early Gamma Interferon (IFN-{gamma}) Expression during Murine Listeriosis: Identification of NK1.1+ CD11c+ Cells as the Primary IFN-{gamma}-Expressing Cells. Infect Immun 75(3):1167-76. [PubMed: 17158904]  [MGI Ref ID J:118505]

Chen L; Lei L; Zhou Z; He J; Xu S; Lu C; Chen J; Yang Z; Wu G; Yeh IT; Zhong G; Wu Y. 2013. Contribution of interleukin-12 p35 (IL-12p35) and IL-12p40 to protective immunity and pathology in mice infected with Chlamydia muridarum. Infect Immun 81(8):2962-71. [PubMed: 23753624]  [MGI Ref ID J:199835]

Chen Z; Duan RS; Q HC; Wu Q; Mix E; Winblad B; Ljunggren HG; Zhu J. 2004. IL-12p35 deficiency alleviates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice. Neurobiol Dis 17(2):171-8. [PubMed: 15474355]  [MGI Ref ID J:120018]

Cho JS; Pietras EM; Garcia NC; Ramos RI; Farzam DM; Monroe HR; Magorien JE; Blauvelt A; Kolls JK; Cheung AL; Cheng G; Modlin RL; Miller LS. 2010. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest 120(5):1762-73. [PubMed: 20364087]  [MGI Ref ID J:161481]

Cobb D; Smeltz RB. 2012. Regulation of proinflammatory Th17 responses during Trypanosoma cruzi infection by IL-12 family cytokines. J Immunol 188(8):3766-73. [PubMed: 22412196]  [MGI Ref ID J:184072]

Collison LW; Chaturvedi V; Henderson AL; Giacomin PR; Guy C; Bankoti J; Finkelstein D; Forbes K; Workman CJ; Brown SA; Rehg JE; Jones ML; Ni HT; Artis D; Turk MJ; Vignali DA. 2010. IL-35-mediated induction of a potent regulatory T cell population. Nat Immunol 11(12):1093-101. [PubMed: 20953201]  [MGI Ref ID J:167328]

Collison LW; Pillai MR; Chaturvedi V; Vignali DA. 2009. Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner. J Immunol 182(10):6121-8. [PubMed: 19414764]  [MGI Ref ID J:150297]

Collison LW; Workman CJ; Kuo TT; Boyd K; Wang Y; Vignali KM; Cross R; Sehy D; Blumberg RS; Vignali DA. 2007. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 450(7169):566-9. [PubMed: 18033300]  [MGI Ref ID J:127800]

Conti HR; Shen F; Nayyar N; Stocum E; Sun JN; Lindemann MJ; Ho AW; Hai JH; Yu JJ; Jung JW; Filler SG; Masso-Welch P; Edgerton M; Gaffen SL. 2009. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J Exp Med 206(2):299-311. [PubMed: 19204111]  [MGI Ref ID J:146451]

Cooper AM; Kipnis A; Turner J; Magram J; Ferrante J; Orme IM. 2002. Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present. J Immunol 168(3):1322-7. [PubMed: 11801672]  [MGI Ref ID J:73949]

Copin R; Vitry MA; Hanot Mambres D; Machelart A; De Trez C; Vanderwinden JM; Magez S; Akira S; Ryffel B; Carlier Y; Letesson JJ; Muraille E. 2012. In situ microscopy analysis reveals local innate immune response developed around Brucella infected cells in resistant and susceptible mice. PLoS Pathog 8(3):e1002575. [PubMed: 22479178]  [MGI Ref ID J:195395]

Cua DJ; Sherlock J; Chen Y; Murphy CA; Joyce B; Seymour B; Lucian L; To W; Kwan S; Churakova T; Zurawski S; Wiekowski M; Lira SA; Gorman D; Kastelein RA; Sedgwick JD. 2003. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421(6924):744-8. [PubMed: 12610626]  [MGI Ref ID J:89968]

Davidson MG; Alonso MN; Yuan R; Axtell RC; Kenkel JA; Suhoski MM; Gonzalez JC; Steinman L; Engleman EG. 2013. Th17 cells induce Th1-polarizing monocyte-derived dendritic cells. J Immunol 191(3):1175-87. [PubMed: 23794631]  [MGI Ref ID J:205439]

Denkinger CM; Denkinger MD; Forsthuber TG. 2007. Pertussis toxin-induced cytokine differentiation and clonal expansion of T cells is mediated predominantly via costimulation. Cell Immunol 246(1):46-54. [PubMed: 17601518]  [MGI Ref ID J:123551]

Dokun AO; Chu DT; Yang L; Bendelac AS; Yokoyama WM. 2001. Analysis of in situ NK cell responses during viral infection. J Immunol 167(9):5286-93. [PubMed: 11673544]  [MGI Ref ID J:72673]

Dong H; Franklin NA; Roberts DJ; Yagita H; Glennie MJ; Bullock TN. 2012. CD27 stimulation promotes the frequency of IL-7 receptor-expressing memory precursors and prevents IL-12-mediated loss of CD8(+) T cell memory in the absence of CD4(+) T cell help. J Immunol 188(8):3829-38. [PubMed: 22422886]  [MGI Ref ID J:184064]

Doodes PD; Cao Y; Hamel KM; Wang Y; Farkas B; Iwakura Y; Finnegan A. 2008. Development of proteoglycan-induced arthritis is independent of IL-17. J Immunol 181(1):329-37. [PubMed: 18566398]  [MGI Ref ID J:137406]

Doolan DL; Hoffman SL. 1999. IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii model. J Immunol 163(2):884-92. [PubMed: 10395683]  [MGI Ref ID J:119784]

Esche C; Gambotto A; Satoh Y; Gerein V; Robbins PD; Watkins SC; Lotze MT; Shurin MR. 1999. CD154 inhibits tumor-induced apoptosis in dendritic cells and tumor growth. Eur J Immunol 29(7):2148-55. [PubMed: 10427977]  [MGI Ref ID J:115301]

Esche C; Subbotin VM; Hunter O; Peron JM; Maliszewski C; Lotze MT; Shurin MR. 1999. Differential regulation of epidermal and dermal dendritic cells by IL-12 and Flt3 ligand. J Invest Dermatol 113(6):1028-32. [PubMed: 10594747]  [MGI Ref ID J:118447]

Evel-Kabler K; Song XT; Aldrich M; Huang XF; Chen SY. 2006. SOCS1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling. J Clin Invest 116(1):90-100. [PubMed: 16357940]  [MGI Ref ID J:105256]

Fairweather D; Frisancho-Kiss S; Yusung SA; Barrett MA; Davis SE; Steele RA; Gatewood SJ; Rose NR. 2005. IL-12 protects against coxsackievirus B3-induced myocarditis by increasing IFN-gamma and macrophage and neutrophil populations in the heart. J Immunol 174(1):261-9. [PubMed: 15611248]  [MGI Ref ID J:95857]

Fauconnier M; Palomo J; Bourigault ML; Meme S; Szeremeta F; Beloeil JC; Danneels A; Charron S; Rihet P; Ryffel B; Quesniaux VF. 2012. IL-12Rbeta2 is essential for the development of experimental cerebral malaria. J Immunol 188(4):1905-14. [PubMed: 22238458]  [MGI Ref ID J:181195]

Feng CG; Kaviratne M; Rothfuchs AG; Cheever A; Hieny S; Young HA; Wynn TA; Sher A. 2006. NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis. J Immunol 177(10):7086-93. [PubMed: 17082625]  [MGI Ref ID J:140483]

Frank GM; Divito SJ; Maker DM; Xu M; Hendricks RL. 2010. A novel p40-independent function of IL-12p35 is required for progression and maintenance of herpes stromal keratitis. Invest Ophthalmol Vis Sci 51(7):3591-8. [PubMed: 20207959]  [MGI Ref ID J:164098]

Freudenberg MA; Merlin T; Kalis C; Chvatchko Y; Stubig H; Galanos C. 2002. Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling. J Immunol 169(4):1665-8. [PubMed: 12165484]  [MGI Ref ID J:120706]

Fujita M; Zhu X; Ueda R; Sasaki K; Kohanbash G; Kastenhuber ER; McDonald HA; Gibson GA; Watkins SC; Muthuswamy R; Kalinski P; Okada H. 2009. Effective immunotherapy against murine gliomas using type 1 polarizing dendritic cells--significant roles of CXCL10. Cancer Res 69(4):1587-95. [PubMed: 19190335]  [MGI Ref ID J:146507]

Gorbachev AV; Fairchild RL. 2004. CD40 engagement enhances antigen-presenting langerhans cell priming of IFN-gamma-producing CD4+ and CD8+ T cells independently of IL-12. J Immunol 173(4):2443-52. [PubMed: 15294958]  [MGI Ref ID J:92689]

Gran B; Zhang GX; Yu S; Li J; Chen XH; Ventura ES; Kamoun M; Rostami A. 2002. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J Immunol 169(12):7104-10. [PubMed: 12471147]  [MGI Ref ID J:118415]

Gutcher I; Urich E; Wolter K; Prinz M; Becher B. 2006. Interleukin 18-independent engagement of interleukin 18 receptor-alpha is required for autoimmune inflammation. Nat Immunol 7(9):946-53. [PubMed: 16906165]  [MGI Ref ID J:112650]

Happel KI; Dubin PJ; Zheng M; Ghilardi N; Lockhart C; Quinton LJ; Odden AR; Shellito JE; Bagby GJ; Nelson S; Kolls JK. 2005. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med 202(6):761-9. [PubMed: 16157683]  [MGI Ref ID J:107457]

Hazlett LD; Rudner XL; McClellan SA; Barrett RP; Lighvani S. 2002. Role of IL-12 and IFN-gamma in Pseudomonas aeruginosa corneal infection. Invest Ophthalmol Vis Sci 43(2):419-24. [PubMed: 11818386]  [MGI Ref ID J:74264]

Henry CJ; Ornelles DA; Mitchell LM; Brzoza-Lewis KL; Hiltbold EM. 2008. IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17. J Immunol 181(12):8576-84. [PubMed: 19050277]  [MGI Ref ID J:142058]

Hoeman CM; Dhakal M; Zaghouani AA; Cascio JA; Wan X; Khairallah MT; Chen W; Zaghouani H. 2013. Developmental expression of IL-12Rbeta2 on murine naive neonatal T cells counters the upregulation of IL-13Ralpha1 on primary Th1 cells and balances immunity in the newborn. J Immunol 190(12):6155-63. [PubMed: 23650613]  [MGI Ref ID J:204760]

Holscher C; Atkinson RA; Arendse B; Brown N; Myburgh E; Alber G; Brombacher F. 2001. A protective and agonistic function of IL-12p40 in mycobacterial infection. J Immunol 167(12):6957-66. [PubMed: 11739515]  [MGI Ref ID J:73093]

Hong KJ; Wickstrum JR; Yeh HW; Parmely MJ. 2007. Toll-like receptor 2 controls the gamma interferon response to Francisella tularensis by mouse liver lymphocytes. Infect Immun 75(11):5338-45. [PubMed: 17785474]  [MGI Ref ID J:126365]

Hou B; Reizis B; Defranco AL. 2008. Toll-like Receptors Activate Innate and Adaptive Immunity by using Dendritic Cell-Intrinsic and -Extrinsic Mechanisms. Immunity 29(2):272-82. [PubMed: 18656388]  [MGI Ref ID J:139001]

Huang G; Wang Y; Chi H. 2013. Control of T cell fates and immune tolerance by p38alpha signaling in mucosal CD103+ dendritic cells. J Immunol 191(2):650-9. [PubMed: 23752611]  [MGI Ref ID J:204825]

Huang G; Wang Y; Shi LZ; Kanneganti TD; Chi H. 2011. Signaling by the Phosphatase MKP-1 in Dendritic Cells Imprints Distinct Effector and Regulatory T Cell Fates. Immunity 35(1):45-58. [PubMed: 21723158]  [MGI Ref ID J:174378]

Huaux F; Arras M; Tomasi D; Barbarin V; Delos M; Coutelier JP; Vink A; Phan SH; Renauld JC; Lison D. 2002. A profibrotic function of IL-12p40 in experimental pulmonary fibrosis. J Immunol 169(5):2653-61. [PubMed: 12193738]  [MGI Ref ID J:120205]

Janelsins BM; Sumpter TL; Tkacheva OA; Rojas-Canales DM; Erdos G; Mathers AR; Shufesky WJ; Storkus WJ; Falo LD Jr; Morelli AE; Larregina AT. 2013. Neurokinin-1 receptor agonists bias therapeutic dendritic cells to induce type 1 immunity by licensing host dendritic cells to produce IL-12. Blood 121(15):2923-33. [PubMed: 23365459]  [MGI Ref ID J:196402]

Jantschitsch C; Weichenthal M; Proksch E; Schwarz T; Schwarz A. 2012. IL-12 and IL-23 affect photocarcinogenesis differently. J Invest Dermatol 132(5):1479-86. [PubMed: 22297634]  [MGI Ref ID J:185239]

Jimenez F; Quinones MP; Martinez HG; Estrada CA; Clark K; Garavito E; Ibarra J; Melby PC; Ahuja SS. 2010. CCR2 plays a critical role in dendritic cell maturation: possible role of CCL2 and NF-kappaB. J Immunol 184(10):5571-81. [PubMed: 20404272]  [MGI Ref ID J:160985]

Kagami S; Rizzo HL; Kurtz SE; Miller LS; Blauvelt A. 2010. IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicans. J Immunol 185(9):5453-62. [PubMed: 20921529]  [MGI Ref ID J:165179]

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Wuthrich M; Gern B; Hung CY; Ersland K; Rocco N; Pick-Jacobs J; Galles K; Filutowicz H; Warner T; Evans M; Cole G; Klein B. 2011. Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice. J Clin Invest 121(2):554-68. [PubMed: 21206087]  [MGI Ref ID J:171835]

Xiao Z; Casey KA; Jameson SC; Curtsinger JM; Mescher MF. 2009. Programming for CD8 T cell memory development requires IL-12 or type I IFN. J Immunol 182(5):2786-94. [PubMed: 19234173]  [MGI Ref ID J:146256]

Yang CY; Leung PS; Yang GX; Kenny TP; Zhang W; Coppel R; Norman GL; Ansari AA; Mackay IR; Worman HJ; Gershwin ME. 2012. Epitope-specific anti-nuclear antibodies are expressed in a mouse model of primary biliary cirrhosis and are cytokine-dependent. Clin Exp Immunol 168(3):261-7. [PubMed: 22519587]  [MGI Ref ID J:184866]

Yen D; Cheung J; Scheerens H; Poulet F; McClanahan T; McKenzie B; Kleinschek MA; Owyang A; Mattson J; Blumenschein W; Murphy E; Sathe M; Cua DJ; Kastelein RA; Rennick D. 2006. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 116(5):1310-6. [PubMed: 16670770]  [MGI Ref ID J:108946]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryThis strain is maintained by homozygous sibling matings. Expected coat color from breeding:Black
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $177.00Female or MaleHomozygous for Il12atm1Jm  
Price per Pair (US dollars $)Pair Genotype
$354.00Homozygous for Il12atm1Jm x Homozygous for Il12atm1Jm  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $230.10Female or MaleHomozygous for Il12atm1Jm  
Price per Pair (US dollars $)Pair Genotype
$460.20Homozygous for Il12atm1Jm x Homozygous for Il12atm1Jm  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
Surgical and Preconditioning Services
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Tel: 1-800-422-6423 or 1-207-288-5845
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Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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