JAX Mice Database - 002693 B6.129S1-Il12b<tm1Jm>/J

Strain Name:	B6.129S1-Il12b^tm1Jm/J
Stock Number:	002693
Availability:	Level 4
	Use Restrictions Apply, see *Terms of Use*

Description
Phenotype
Genes & alleles
Genotyping
Health & husbandry
References
Purchasing information
Terms of Use

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.

Visit our online Nomenclature tutorial.

Additional information on Congenic nomenclature.

Mating System Homozygote x Homozygote (Female x Male)

Species laboratory mouse

Background Strain C57BL/6

Donor Strain 129S1 via W9.5 ES (+^Kitl-SlJ)

Generation N11F25 (20-DEC-06)

Donating Investigator Jeanne Magram, Boehringer Ingelheim Pharmaceuticals,Inc

Appearance
black
Related Genotype: a/a
Description
Mice homozygous for the Il12b^tm1Jmtargeted mutation have a severely restricted ability to mount a TH1 response to in vivo endotoxin administration as evidenced by decreased interferon-gamma production although IL2 (IL-2) production is not compromised. The TH2 response is enhanced as evidenced by increased secretion of IL4 (IL-4). Delayed type hypersensitivity (DTH) responses are reduced. Also see the Il12a-deficient strains (Stock No. 002691 & 002692).

Control Information

	Control
	000664 C57BL/6J

Considerations for Choosing Controls

Related Strains

Strains carrying Il12b^tm1Jm allele

002694 C.129S1-Il12b^tm1Jm/J

View Strains carrying Il12b^tm1Jm (1 strain)

Strains carrying other alleles of Il12b

006412 B6.129-Il12b^tm1Lky/J

View Strains carrying other alleles of Il12b (1 strain)

Additional Web Information

Congenic Nomenclature
Genetic Quality Control Annual Report

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
assigned by genotype

Il12b^tm1Jm/Il12b^tm1Jm
B6.129S1-Il12b^tm1Jm/J
immune system phenotype

abnormal granulocyte physiology (MGI Ref ID J:111568)

fewer than expected granulocytes in the dermis of carcinogen treated skin

abnormal lymphocyte physiology (MGI Ref ID J:120806)

lymph node cells from keyhole limpet hemocyanin (KLH) immunized mice are severely impaired in their ability to produce IFNG when cultured with KLH; however, their production of IL4 is increased

abnormal CD8-positive T cell physiology (MGI Ref ID J:111568)

dramatic increase in the number of cytotoxic CD8+ cells in the dermis and epidermis of carcinogen treated skin

abnormal NK cell physiology (MGI Ref ID J:120806)

mean NK lytic activity is about 66% of controls; however when cultured with IL2 lytic activity is similar to controls

abnormal macrophage physiology (MGI Ref ID J:111568)

fewer than expected macrophages in the dermis of carcinogen treated skin

decreased circulating interferon-gamma level (MGI Ref ID J:120806)

serum levels of IFNG in LPS-injected mice are only 17 +/- 5% of LPS-induced controls

decreased interleukin-17 secretion (MGI Ref ID J:111568)

barely detectable levels of IL17 in the skin after carcinogen treatment unlike wild-type mice which express high levels of IL17

decreased susceptibility to type IV hypersensitivity reaction (MGI Ref ID J:120806)

specific foot pad swelling 48 hours after challenge with methylated bovine serum albumin is inhibited by 47 +/- 3% compared to wild-type mice; however, cytotoxic T lymphocyte responses are similar to wild-type

increased susceptibility to bacterial infection (MGI Ref ID J:120806)

vaccination does not produce a protective response to M. tuberculosis

tumorigenesis

decreased incidence of chemically-induced tumors (MGI Ref ID J:111568)

resistant to induction of papillomas compared to wild-type mice after treatment with DMBA and TPA in a 2 step skin carcinogenesis protocol

however, there is an increase in the incidence of tumors following intradermal challenge with PDV squamous carcinoma cells

homeostasis/metabolism phenotype

decreased circulating interferon-gamma level (MGI Ref ID J:120806)

serum levels of IFNG in LPS-injected mice are only 17 +/- 5% of LPS-induced controls

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.
Il12b^tm1Jm/Il12b^tm1Jm
129S1/Sv-Il12b^tm1Jm
immune system phenotype

abnormal CD4-positive T cell physiology (MGI Ref ID J:34164)

75 days after infection Ifng mRNA expression in CD4+ cells is more than 50-fold lower than in wild-type

75 days after infection Il4 mRNA expression in CD4+ cells is 100-fold higher than in wild-type

draining lymph node cells in L. major infected mice produce significantly more IL4 compared to IFNG in contrast to wild-type mice which express more IFNG than IL4

decreased susceptibility to type IV hypersensitivity reaction (MGI Ref ID J:34164)

do not show any delayed type hypersensitivity response to application of Leishmania antigen to the uninfected footpad 41 days after initial infection with L. major

increased susceptibility to parasitic infection (MGI Ref ID J:34164)

develop large lesions unlike wild-type 129S1/Sv mice after infection with Leishmania major

75 days after infection with L. major parasite numbers in the draining lymph nodes are increased 400-fold compared to wild-type mice

Il12b^tm1Jm/Il12b^tm1Jm
involves: 129S1/SvImJ
immune system phenotype

abnormal T-helper 1 physiology (MGI Ref ID J:46514)

in vivo Th1 cell response is impaired as indicated by the low amounts of IFN-gamma produced by T cells in response to M. bovis antigens

decreased interferon-gamma secretion (MGI Ref ID J:46514)

splenic T cells produce about 1/4^th the amount of IFN-gamma as T cells from wild-type mice 14 days after injection with heat killed M. Bovis

impaired NK cell cytolysis (MGI Ref ID J:46514)

the killing activity of splenic NK cells is about 2/3^rds that of wild-type mice as measured by in vitro co-culturing with YAC-1 target cells

normal level of target cell killing can be restored by in vivo pretreatment with IL-18 for two days or the addition of IL-18 to the co-culture

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:
Il12b^tm1Jm related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines

Genes & Alleles

Gene & Allele Information


Allele Symbol		Il12b^tm1Jm
Allele Name		targeted mutation 1, Jeanne Magram
Allele Type		Targeted (knock-out)
Common Name(s)		IL-12 p40-; IL-12^-; IL-12KO; IL-12b; IL-12p40-; IL-12p40-KO; IL12p40-; Il12b-; p40-;
Mutation Made By		Jeanne Magram, Boehringer Ingelheim Pharmaceuticals,Inc
Strain of Origin		129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
ES Cell Line Name		W9.5/W95
ES Cell Line Strain		129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Gene Symbol and Name		Il12b, interleukin 12b
Chromosome		11
Gene Common Name(s)		CLMF; CLMF2; IL-12 p40; IL-12B; IL-23 subunit p40; Il-12b; Il-12p40; Il12; NKSF; NKSF2;
Molecular Note		A neomycin resistance cassette replaced a portion of exon 3 of the gene. [MGI Ref ID J:33141]

Genotyping

Genotyping Information

Genotyping Protocols
Il12b^tm1Jm, SEP PCR, vers. 2

Helpful Links

Optimizing PCR Protocols

References

Selected Reference(s)

Magram J; Connaughton SE; Warrier RR; Carvajal DM; Wu CY; Ferrante J; Stewart C; Sarmiento U; Faherty DA; Gately MK. 1996. IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity 4(5):471-81. [PubMed: 8630732] [MGI Ref ID J:33141]

Additional References

Chang J; Cho JH; Lee SW; Choi SY; Ha SJ; Sung YC. 2004. IL-12 priming during in vitro antigenic stimulation changes properties of CD8 T cells and increases generation of effector and memory cells. J Immunol 172(5):2818-26. [PubMed: 14978082] [MGI Ref ID J:88236]

Cooper AM; Magram J; Ferrante J; Orme IM. 1997. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis. J Exp Med 186(1):39-45. [PubMed: 9206995] [MGI Ref ID J:41494]

Cua DJ; Sherlock J; Chen Y; Murphy CA; Joyce B; Seymour B; Lucian L; To W; Kwan S; Churakova T; Zurawski S; Wiekowski M; Lira SA; Gorman D; Kastelein RA; Sedgwick JD. 2003. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421(6924):744-8. [PubMed: 12610626] [MGI Ref ID J:89968]

Ghilardi N; Kljavin N; Chen Q; Lucas S; Gurney AL; De Sauvage FJ. 2004. Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J Immunol 172(5):2827-33. [PubMed: 14978083] [MGI Ref ID J:88235]

Hayashi T; Rao SP; Takabayashi K; Van Uden JH; Kornbluth RS; Baird SM; Taylor MW; Carson DA; Catanzaro A; Raz E. 2001. Enhancement of Innate Immunity against Mycobacterium avium Infection by Immunostimulatory DNA Is Mediated by Indoleamine 2,3-Dioxygenase. Infect Immun 69(10):6156-64. [PubMed: 11553555] [MGI Ref ID J:71646]

Hazlett LD; Rudner XL; McClellan SA; Barrett RP; Lighvani S. 2002. Role of IL-12 and IFN-gamma in Pseudomonas aeruginosa corneal infection. Invest Ophthalmol Vis Sci 43(2):419-24. [PubMed: 11818386] [MGI Ref ID J:74264]

Kawakami K; Kinjo Y; Yara S; Uezu K; Koguchi Y; Tohyama M; Azuma M; Takeda K; Akira S; Saito A. 2001. Enhanced Gamma Interferon Production through Activation of Valpha14(+) Natural Killer T Cells by alpha-Galactosylceramide in Interleukin-18-Deficient Mice with Systemic Cryptococcosis. Infect Immun 69(11):6643-50. [PubMed: 11598033] [MGI Ref ID J:72191]

Ko J; Gendron-Fitzpatrick A; Splitter GA. 2002. Susceptibility of IFN regulatory factor-1 and IFN consensus sequence binding protein-deficient mice to brucellosis. J Immunol 168(5):2433-40. [PubMed: 11859135] [MGI Ref ID J:74725]

Li L; Hsu HC; Stockard CR; Yang P; Zhou J; Wu Q; Grizzle WE; Mountz JD. 2004. IL-12 inhibits thymic involution by enhancing IL-7- and IL-2-induced thymocyte proliferation. J Immunol 172(5):2909-16. [PubMed: 14978093] [MGI Ref ID J:88230]

Mattner F; Magram J; Ferrante J; Launois P; Di Padova K; Behin R; Gately MK; Louis JA; Alber G. 1996. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur J Immunol 26(7):1553-9. [PubMed: 8766560] [MGI Ref ID J:34164]

McIntyre KW; Shuster DJ; Gillooly KM; Warrier RR; Connaughton SE ; Hall LB ; Arp LH ; Gately MK ; Magram J. 1996. Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice. Eur J Immunol 26(12):2933-8. [PubMed: 8977288] [MGI Ref ID J:37075]

Nguyen KB; Salazar-Mather TP; Dalod MY; Van Deusen JB; Wei XQ; Liew FY; Caligiuri MA; Durbin JE; Biron CA. 2002. Coordinated and distinct roles for IFN-alphabeta, IL-12, and IL-15 regulation of NK cell responses to viral infection. J Immunol 169(8):4279-87. [PubMed: 12370359] [MGI Ref ID J:79552]

Piccotti JR; Li K; Chan SY; Ferrante J; Magram J; Eichwald EJ; Bishop DK. 1998. Alloantigen-reactive Th1 development in IL-12-deficient mice. J Immunol 160(3):1132-8. [PubMed: 9570526] [MGI Ref ID J:90552]

Pien GC; Nguyen KB; Malmgaard L; Satoskar AR; Biron CA. 2002. A unique mechanism for innate cytokine promotion of T cell responses to viral infections. J Immunol 169(10):5827-37. [PubMed: 12421964] [MGI Ref ID J:80075]

Van Uden JH; Tran CH; Carson DA; Raz E. 2001. Type I interferon is required to mount an adaptive response to immunostimulatory DNA. Eur J Immunol 31(11):3281-90. [PubMed: 11745345] [MGI Ref ID J:72586]
Il12b^tm1Jm related

Adachi K; Tsutsui H; Kashiwamura S; Seki E; Nakano H; Takeuchi O; Takeda K; Okumura K; Van Kaer L; Okamura H; Akira S; Nakanishi K. 2001. Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism. J Immunol 167(10):5928-34. [PubMed: 11698470] [MGI Ref ID J:118004]

Akhiani AA; Pappo J; Kabok Z; Schon K; Gao W; Franzen LE; Lycke N. 2002. Protection against Helicobacter pylori infection following immunization is IL-12-dependent and mediated by Th1 cells. J Immunol 169(12):6977-84. [PubMed: 12471132] [MGI Ref ID J:118009]

Aliberti J; Viola JP; Vieira-de-Abreu A; Bozza PT; Sher A; Scharfstein J. 2003. Cutting edge: Bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization. J Immunol 170(11):5349-53. [PubMed: 12759407] [MGI Ref ID J:83453]

Amprey JL; Im JS; Turco SJ; Murray HW; Illarionov PA; Besra GS; Porcelli SA; Spath GF. 2004. A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan. J Exp Med 200(7):895-904. [PubMed: 15466622] [MGI Ref ID J:93947]

Anderson S; Shires VL; Wilson RA; Mountford AP. 1999. Formation of multinucleated giant cells in the mouse lung is promoted in the absence of interleukin-12. Am J Respir Cell Mol Biol 20(3):371-8. [PubMed: 10030834] [MGI Ref ID J:114254]

Ariga H; Shimohakamada Y; Nakada M; Tokunaga T; Kikuchi T; Kariyone A; Tamura T; Takatsu K. 2007. Instruction of naive CD4+ T-cell fate to T-bet expression and T helper 1 development: roles of T-cell receptor-mediated signals. Immunology 122(2):210-21. [PubMed: 17490433] [MGI Ref ID J:125688]

Askenase PW; Itakura A; Leite-de-Moraes MC; Lisbonne M; Roongapinun S; Goldstein DR; Szczepanik M. 2005. TLR-dependent IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo. J Immunol 175(10):6390-401. [PubMed: 16272291] [MGI Ref ID J:119381]

Barr DP; Belz GT; Reading PC; Wojtasiak M; Whitney PG; Heath WR; Carbone FR; Brooks AG. 2007. A role for plasmacytoid dendritic cells in the rapid IL-18-dependent activation of NK cells following HSV-1 infection. Eur J Immunol 37(5):1334-42. [PubMed: 17407097] [MGI Ref ID J:123560]

Bastos KR; Alvarez JM; Marinho CR; Rizzo LV; Lima MR. 2002. Macrophages from IL-12p40-deficient mice have a bias toward the M2 activation profile. J Leukoc Biol 71(2):271-8. [PubMed: 11818448] [MGI Ref ID J:74693]

Bastos KR; de Deus Vieira de Moraes L; Zago CA; Marinho CR; Russo M; Alvarez JM; D'Imperio Lima MR. 2005. Analysis of the activation profile of dendritic cells derived from the bone marrow of interleukin-12/interleukin-23-deficient mice. Immunology 114(4):499-506. [PubMed: 15804287] [MGI Ref ID J:97435]

Becher B; Durell BG; Noelle RJ. 2002. Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J Clin Invest 110(4):493-7. [PubMed: 12189243] [MGI Ref ID J:78574]

Beenhouwer DO; Shapiro S; Feldmesser M; Casadevall A; Scharff MD. 2001. Both Th1 and Th2 Cytokines Affect the Ability of Monoclonal Antibodies To Protect Mice against Cryptococcus neoformans. Infect Immun 69(10):6445-55. [PubMed: 11553589] [MGI Ref ID J:71570]

Belz GT; Bedoui S; Kupresanin F; Carbone FR; Heath WR. 2007. Minimal activation of memory CD8(+) T cell by tissue-derived dendritic cells favors the stimulation of naive CD8(+) T cells. Nat Immunol 8(10):1060-6. [PubMed: 17767161] [MGI Ref ID J:125274]

Blazar BR; Lees CJ; Martin PJ; Noelle RJ; Kwon B; Murphy W; Taylor PA. 2000. Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions. J Immunol 165(9):4901-9. [PubMed: 11046015] [MGI Ref ID J:118027]

Boelen A; Kwakkel J; Platvoet-ter Schiphorst M; Baur A; Kohrle J; Wiersinga WM. 2004. Contribution of interleukin-12 to the pathogenesis of non-thyroidal illness. Horm Metab Res 36(2):101-6. [PubMed: 15002060] [MGI Ref ID J:120558]

Brummel R; Roberts TL; Stacey KJ; Lenert P. 2006. Higher-order CpG-DNA stimulation reveals distinct activation requirements for marginal zone and follicular B cells in lupus mice. Eur J Immunol 36(7):1951-62. [PubMed: 16791898] [MGI Ref ID J:115797]

Burt BM; Plitas G; Stableford JA; Nguyen HM; Bamboat ZM; Pillarisetty VG; DeMatteo RP. 2008. CD11c identifies a subset of murine liver natural killer cells that responds to adenoviral hepatitis. J Leukoc Biol 84(4):1039-46. [PubMed: 18664530] [MGI Ref ID J:140218]

Buxbaum LU; Denise H; Coombs GH; Alexander J; Mottram JC; Scott P. 2003. Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity. J Immunol 171(7):3711-7. [PubMed: 14500670] [MGI Ref ID J:120395]

Buxbaum LU; Uzonna JE; Goldschmidt MH; Scott P. 2002. Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent. Eur J Immunol 32(11):3206-15. [PubMed: 12555666] [MGI Ref ID J:115538]

Camoglio L; Juffermans NP; Peppelenbosch M; te Velde AA; ten Kate FJ; van Deventer SJ; Kopf M. 2002. Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis. Eur J Immunol 32(1):261-9. [PubMed: 11782017] [MGI Ref ID J:73931]

Carlow DA; Williams MJ; Ziltener HJ. 2005. Inducing P-selectin ligand formation in CD8 T cells: IL-2 and IL-12 are active in vitro but not required in vivo. J Immunol 174(7):3959-66. [PubMed: 15778352] [MGI Ref ID J:110004]

Castilow EM; Legge KL; Varga SM. 2008. Cutting edge: Eosinophils do not contribute to respiratory syncytial virus vaccine-enhanced disease. J Immunol 181(10):6692-6. [PubMed: 18981084] [MGI Ref ID J:140954]

Cenci E; Mencacci A; Del Sero G; Bacci A; Montagnoli C; d'Ostiani CF; Mosci P; Bachmann M; Bistoni F; Kopf M; Romani L. 1999. Interleukin-4 causes susceptibility to invasive pulmonary aspergillosis through suppression of protective type I responses. J Infect Dis 180(6):1957-68. [PubMed: 10558953] [MGI Ref ID J:119841]

Chackerian AA; Chen SJ; Brodie SJ; Mattson JD; McClanahan TK; Kastelein RA; Bowman EP. 2006. Neutralization or absence of the interleukin-23 pathway does not compromise immunity to mycobacterial infection. Infect Immun 74(11):6092-9. [PubMed: 16923792] [MGI Ref ID J:113448]

Chang J; Cho JH; Lee SW; Choi SY; Ha SJ; Sung YC. 2004. IL-12 priming during in vitro antigenic stimulation changes properties of CD8 T cells and increases generation of effector and memory cells. J Immunol 172(5):2818-26. [PubMed: 14978082] [MGI Ref ID J:88236]

Chang JT; Shevach EM; Segal BM. 1999. Regulation of interleukin (IL)-12 receptor beta2 subunit expression by endogenous IL-12: a critical step in the differentiation of pathogenic autoreactive T cells. J Exp Med 189(6):969-78. [PubMed: 10075980] [MGI Ref ID J:53619]

Chen K; Wei Y; Sharp GC; Braley-Mullen H. 2001. Induction of experimental autoimmune thyroiditis in IL-12-/- mice. J Immunol 167(3):1720-7. [PubMed: 11466396] [MGI Ref ID J:120397]

Chiaramonte MG; Hesse M; Cheever AW; Wynn TA. 2000. CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism. J Immunol 164(2):973-85. [PubMed: 10623847] [MGI Ref ID J:127058]

Chiaramonte MG; Mentink-Kane M; Jacobson BA; Cheever AW; Whitters MJ; Goad ME; Wong A; Collins M; Donaldson DD; Grusby MJ; Wynn TA. 2003. Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. J Exp Med 197(6):687-701. [PubMed: 12642601] [MGI Ref ID J:124413]

Chiodoni C; Stoppacciaro A; Sangaletti S; Gri G; Cappetti B; Koezuka Y; Colombo MP. 2001. Different requirements for alpha-galactosylceramide and recombinant IL-12 antitumor activity in the treatment of C-26 colon carcinoma hepatic metastases. Eur J Immunol 31(10):3101-10. [PubMed: 11592087] [MGI Ref ID J:115631]

Cooper AM; Kipnis A; Turner J; Magram J; Ferrante J; Orme IM. 2002. Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present. J Immunol 168(3):1322-7. [PubMed: 11801672] [MGI Ref ID J:73949]

Cooper AM; Magram J; Ferrante J; Orme IM. 1997. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis. J Exp Med 186(1):39-45. [PubMed: 9206995] [MGI Ref ID J:41494]

Crow AR; Song S; Semple JW; Freedman J; Lazarus AH. 2007. A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg? Blood 109(1):155-8. [PubMed: 16954498] [MGI Ref ID J:142178]

Croy BA; Ashkar AA; Foster RA; DiSanto JP; Magram J; Carson D; Gendler SJ; Grusby MJ; Wagner N; Muller W; Guimond MJ. 1997. Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy J Reprod Immunol 35(2):111-33. [PubMed: 9421796] [MGI Ref ID J:44813]

Cua DJ; Sherlock J; Chen Y; Murphy CA; Joyce B; Seymour B; Lucian L; To W; Kwan S; Churakova T; Zurawski S; Wiekowski M; Lira SA; Gorman D; Kastelein RA; Sedgwick JD. 2003. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421(6924):744-8. [PubMed: 12610626] [MGI Ref ID J:89968]

Davenport P; Tipping PG. 2003. The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice. Am J Pathol 163(3):1117-25. [PubMed: 12937153] [MGI Ref ID J:85172]

Denton AE; Doherty PC; Turner SJ; La Gruta NL. 2007. IL-18, but not IL-12, is required for optimal cytokine production by influenza virus-specific CD8(+) T cells. Eur J Immunol 37(2):368-75. [PubMed: 17219365] [MGI Ref ID J:117879]

Dohi T; Fujihashi K; Kiyono H; Elson CO; McGhee JR. 2000. Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis. Gastroenterology 119(3):724-33. [PubMed: 10982767] [MGI Ref ID J:64230]

Dokun AO; Chu DT; Yang L; Bendelac AS; Yokoyama WM. 2001. Analysis of in situ NK cell responses during viral infection. J Immunol 167(9):5286-93. [PubMed: 11673544] [MGI Ref ID J:72673]

Doodes PD; Cao Y; Hamel KM; Wang Y; Farkas B; Iwakura Y; Finnegan A. 2008. Development of proteoglycan-induced arthritis is independent of IL-17. J Immunol 181(1):329-37. [PubMed: 18566398] [MGI Ref ID J:137406]

Doolan DL; Hoffman SL. 1999. IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii model. J Immunol 163(2):884-92. [PubMed: 10395683] [MGI Ref ID J:119784]

Duthie MS; Kahn M; White M; Kapur RP; Kahn SJ. 2005. Both CD1d antigen presentation and interleukin-12 are required to activate natural killer T cells during Trypanosoma cruzi infection. Infect Immun 73(3):1890-4. [PubMed: 15731095] [MGI Ref ID J:96678]

Eberl G; Brawand P; MacDonald HR. 2000. Selective bystander proliferation of memory CD4+ and CD8+ T cells upon NK T or T cell activation. J Immunol 165(8):4305-11. [PubMed: 11035065] [MGI Ref ID J:119149]

Ehigiator HN; Romagnoli P; Borgelt K; Fernandez M; McNair N; Secor WE; Mead JR. 2005. Mucosal cytokine and antigen-specific responses to Cryptosporidium parvum in IL-12p40 KO mice. Parasite Immunol 27(1-2):17-28. [PubMed: 15813719] [MGI Ref ID J:110161]

Ehl S; Bischoff R; Ostler T; Vallbracht S; Schulte-Monting J; Poltorak A; Freudenberg M. 2004. The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus. Eur J Immunol 34(4):1146-53. [PubMed: 15048726] [MGI Ref ID J:88878]

Ely KH; Kasper LH; Khan IA. 1999. Augmentation of the CD8+ T cell response by IFN-gamma in IL-12-deficient mice during Toxoplasma gondii infection. J Immunol 162(9):5449-54. [PubMed: 10228024] [MGI Ref ID J:111011]

Eriksson U; Kurrer MO; Sebald W; Brombacher F; Kopf M. 2001. Dual role of the IL-12/IFN-gamma axis in the development of autoimmune myocarditis: induction by IL-12 and protection by IFN-gamma. J Immunol 167(9):5464-9. [PubMed: 11673566] [MGI Ref ID J:72665]

Esche C; Gambotto A; Satoh Y; Gerein V; Robbins PD; Watkins SC; Lotze MT; Shurin MR. 1999. CD154 inhibits tumor-induced apoptosis in dendritic cells and tumor growth. Eur J Immunol 29(7):2148-55. [PubMed: 10427977] [MGI Ref ID J:115301]

Farah CS; Hu Y; Riminton S; Ashman RB. 2006. Distinct roles for interleukin-12p40 and tumour necrosis factor in resistance to oral candidiasis defined by gene-targeting. Oral Microbiol Immunol 21(4):252-5. [PubMed: 16842510] [MGI Ref ID J:136489]

Feng CG; Jankovic D; Kullberg M; Cheever A; Scanga CA; Hieny S; Caspar P; Yap GS; Sher A. 2005. Maintenance of pulmonary Th1 effector function in chronic tuberculosis requires persistent IL-12 production. J Immunol 174(7):4185-92. [PubMed: 15778379] [MGI Ref ID J:97935]

Feng CG; Kaviratne M; Rothfuchs AG; Cheever A; Hieny S; Young HA; Wynn TA; Sher A. 2006. NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis. J Immunol 177(10):7086-93. [PubMed: 17082625] [MGI Ref ID J:140483]

Fischer R; Tome D; McGhee JR; Boyaka PN. 2007. Th1 and Th2 cells are required for both eosinophil- and neutrophil-associated airway inflammatory responses in mice. Biochem Biophys Res Commun 357(1):44-9. [PubMed: 17412309] [MGI Ref ID J:121793]

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Price JD; Simpfendorfer KR; Mantena RR; Holden J; Heath WR; van Rooijen N; Strugnell RA; Wijburg OL. 2007. Gamma interferon-independent effects of interleukin-12 on immunity to Salmonella enterica serovar Typhimurium. Infect Immun 75(12):5753-62. [PubMed: 17875635] [MGI Ref ID J:127653]

Ramirez-Pineda JR; Frohlich A; Berberich C; Moll H. 2004. Dendritic cells (DC) activated by CpG DNA ex vivo are potent inducers of host resistance to an intracellular pathogen that is independent of IL-12 derived from the immunizing DC. J Immunol 172(10):6281-9. [PubMed: 15128817] [MGI Ref ID J:89850]

Reinhardt RL; Hong S; Kang SJ; Wang ZE; Locksley RM. 2006. Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation. J Immunol 177(3):1618-27. [PubMed: 16849470] [MGI Ref ID J:112745]

Rempel JD; Lewkowich IP; HayGlass KT. 2000. Endogenous IL-12 synthesis is not required to prevent hyperexpression of type 2 cytokine and antibody responses. Eur J Immunol 30(2):347-55. [PubMed: 10671189] [MGI Ref ID J:115321]

Robinson RT; Khader SA; Locksley RM; Lien E; Smiley ST; Cooper AM. 2008. Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration. J Immunol 181(8):5560-7. [PubMed: 18832714] [MGI Ref ID J:140760]

Rosas LE; Keiser T; Pyles R; Durbin J; Satoskar AR. 2003. Development of protective immunity against cutaneous leishmaniasis is dependent on STAT1-mediated IFN signaling pathway. Eur J Immunol 33(7):1799-805. [PubMed: 12811839] [MGI Ref ID J:84419]

Rothfuchs AG; Gigliotti D; Palmblad K; Andersson U; Wigzell H; Rottenberg ME. 2001. IFN-alphabeta-dependent, IFN-gamma secretion by bone marrow-derived macrophages controls an intracellular bacterial infection. J Immunol 167(11):6453-61. [PubMed: 11714812] [MGI Ref ID J:72825]

Rottenberg ME; Gigliotti Rothfuchs A; Gigliotti D; Ceausu M; Une C; Levitsky V; Wigzell H. 2000. Regulation and role of IFN-gamma in the innate resistance to infection with Chlamydia pneumoniae. J Immunol 164(9):4812-8. [PubMed: 10779789] [MGI Ref ID J:124531]

Ruan S; McKinley L; Zheng M; Rudner X; D'Souza A; Kolls JK; Shellito JE. 2008. Interleukin-12 and host defense against murine Pneumocystis pneumonia. Infect Immun 76(5):2130-7. [PubMed: 18332204] [MGI Ref ID J:134470]

Rutitzky LI; Lopes da Rosa JR; Stadecker MJ. 2005. Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is dependent on IL-12p40 and correlates with high levels of IL-17. J Immunol 175(6):3920-6. [PubMed: 16148138] [MGI Ref ID J:116693]

Sakamoto H; Zhao LH; Jain F; Kradin R. 2002. IL-12p40(-/-) mice treated with intratracheal bleomycin exhibit decreased pulmonary inflammation and increased fibrosis. Exp Mol Pathol 72(1):1-9. [PubMed: 11784117] [MGI Ref ID J:105860]

Santos LL; Milenkovski GP; Hall PH; Leech M; Sharma L; Takeda K; Akira S; Kitching AR; Morand EF. 2006. IL-18 is redundant in T-cell responses and in joint inflammation in antigen-induced arthritis. Immunol Cell Biol 84(2):166-73. [PubMed: 16519734] [MGI Ref ID J:105836]

Sato A; Iwasaki A. 2004. Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments. Proc Natl Acad Sci U S A 101(46):16274-9. [PubMed: 15534227] [MGI Ref ID J:94732]

Satoskar AR; Rodig S; Telford SR 3rd; Satoskar AA; Ghosh SK; von Lichtenberg F; David JR. 2000. IL-12 gene-deficient C57BL/6 mice are susceptible to Leishmania donovani but have diminished hepatic immunopathology. Eur J Immunol 30(3):834-9. [PubMed: 10741399] [MGI Ref ID J:60891]

Sawaki J; Tsutsui H; Hayashi N; Yasuda K; Akira S; Tanizawa T; Nakanishi K. 2007. Type 1 cytokine/chemokine production by mouse NK cells following activation of their TLR/MyD88-mediated pathways. Int Immunol 19(3):311-20. [PubMed: 17289654] [MGI Ref ID J:118680]

Scharton-Kersten T; Contursi C; Masumi A; Sher A; Ozato K. 1997. Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. J Exp Med 186(9):1523-34. [PubMed: 9348310] [MGI Ref ID J:111178]

Schijns VE; Haagmans BL; Wierda CM; Kruithof B; Heijnen IA; Alber G; Horzinek MC. 1998. Mice lacking IL-12 develop polarized Th1 cells during viral infection. J Immunol 160(8):3958-64. [PubMed: 9558103] [MGI Ref ID J:46942]

Schleicher U; Liese J; Knippertz I; Kurzmann C; Hesse A; Heit A; Fischer JA; Weiss S; Kalinke U; Kunz S; Bogdan C. 2007. NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J Exp Med 204(4):893-906. [PubMed: 17389237] [MGI Ref ID J:125611]

Seki E; Tsutsui H; Tsuji NM; Hayashi N; Adachi K; Nakano H; Futatsugi-Yumikura S; Takeuchi O; Hoshino K; Akira S; Fujimoto J; Nakanishi K. 2002. Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice. J Immunol 169(7):3863-8. [PubMed: 12244183] [MGI Ref ID J:120385]

Shen H; Iwasaki A. 2006. A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide. J Clin Invest 116(8):2237-43. [PubMed: 16878177] [MGI Ref ID J:113124]

Shi M; Ye Z; Umeshappa KS; Moyana T; Xiang J. 2007. Alpha tumor necrosis factor contributes to CD8(+) T cell survival in the transition phase. Biochem Biophys Res Commun 360(3):702-7. [PubMed: 17618911] [MGI Ref ID J:123025]

Simmons CP; Goncalves NS; Ghaem-Maghami M; Bajaj-Elliott M; Clare S; Neves B; Frankel G; Dougan G; MacDonald TT. 2002. Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma. J Immunol 168(4):1804-12. [PubMed: 11823513] [MGI Ref ID J:74480]

Simmons CP; Mastroeni P; Fowler R; Ghaem-maghami M; Lycke N; Pizza M; Rappuoli R; Dougan G. 1999. MHC class I-restricted cytotoxic lymphocyte responses induced by enterotoxin-based mucosal adjuvants. J Immunol 163(12):6502-10. [PubMed: 10586042] [MGI Ref ID J:58977]

Skok J; Poudrier J; Gray D. 1999. Dendritic cell-derived IL-12 promotes B cell induction of Th2 differentiation: a feedback regulation of Th1 development. J Immunol 163(8):4284-91. [PubMed: 10510367] [MGI Ref ID J:119232]

Skokos D; Nussenzweig MC. 2007. CD8- DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS. J Exp Med 204(7):1525-31. [PubMed: 17576775] [MGI Ref ID J:125873]

Smeltz RB; Chen J; Shevach EM. 2005. Transforming growth factor-beta1 enhances the interferon-gamma-dependent, interleukin-12-independent pathway of T helper 1 cell differentiation. Immunology 114(4):484-92. [PubMed: 15804285] [MGI Ref ID J:97437]

Smyth MJ; Thia KY; Street SE; Cretney E; Trapani JA; Taniguchi M; Kawano T; Pelikan SB; Crowe NY; Godfrey DI. 2000. Differential tumor surveillance by natural killer (NK) and NKT cells. J Exp Med 191(4):661-8. [PubMed: 10684858] [MGI Ref ID J:124663]

Soares H; Waechter H; Glaichenhaus N; Mougneau E; Yagita H; Mizenina O; Dudziak D; Nussenzweig MC; Steinman RM. 2007. A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo. J Exp Med 204(5):1095-106. [PubMed: 17438065] [MGI Ref ID J:125741]

Somigliana E; Vigano P; Filardo P; Candiani M; Vignali M; Panina-Bordignon P. 2001. Use of knockout transgenic mice in the study of endometriosis: insights from mice lacking beta(2)-microglobulin and interleukin-12p40. Fertil Steril 75(1):203-6. [PubMed: 11163839] [MGI Ref ID J:66996]

Sonderegger I; Rohn TA; Kurrer MO; Iezzi G; Zou Y; Kastelein RA; Bachmann MF; Kopf M. 2006. Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis. Eur J Immunol 36(11):2849-56. [PubMed: 17039570] [MGI Ref ID J:116998]

Stager S; Maroof A; Zubairi S; Sanos SL; Kopf M; Kaye PM. 2006. Distinct roles for IL-6 and IL-12p40 in mediating protection against Leishmania donovani and the expansion of IL-10+ CD4+ T cells. Eur J Immunol 36(7):1764-71. [PubMed: 16791879] [MGI Ref ID J:115789]

Stobie L; Gurunathan S; Prussin C; Sacks DL; Glaichenhaus N; Wu CY; Seder RA. 2000. The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge. Proc Natl Acad Sci U S A 97(15):8427-32. [PubMed: 10890924] [MGI Ref ID J:63412]

Stokes KY; Clanton EC; Gehrig JL; Granger DN. 2003. Role of interleukin 12 in hypercholesterolemia-induced inflammation. Am J Physiol Heart Circ Physiol 285(6):H2623-9. [PubMed: 12907426] [MGI Ref ID J:108153]

Street SE; Cretney E; Smyth MJ. 2001. Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis. Blood 97(1):192-7. [PubMed: 11133760] [MGI Ref ID J:68550]

Street SE; Trapani JA; MacGregor D; Smyth MJ. 2002. Suppression of lymphoma and epithelial malignancies effected by interferon gamma. J Exp Med 196(1):129-34. [PubMed: 12093877] [MGI Ref ID J:77491]

Su Z; Stevenson MM. 2002. IL-12 is required for antibody-mediated protective immunity against blood-stage Plasmodium chabaudi AS malaria infection in mice. J Immunol 168(3):1348-55. [PubMed: 11801675] [MGI Ref ID J:127287]

Swann JB; Vesely MD; Silva A; Sharkey J; Akira S; Schreiber RD; Smyth MJ. 2008. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc Natl Acad Sci U S A 105(2):652-6. [PubMed: 18178624] [MGI Ref ID J:131026]

Takabayshi K; Corr M; Hayashi T; Redecke V; Beck L; Guiney D; Sheppard D; Raz E. 2006. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity 24(4):475-87. [PubMed: 16618605] [MGI Ref ID J:113350]

Takeda K; Cretney E; Hayakawa Y; Ota T; Akiba H; Ogasawara K; Yagita H; Kinoshita K; Okumura K; Smyth MJ. 2005. TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver. Blood 105(5):2082-9. [PubMed: 15536146] [MGI Ref ID J:98142]

Takeda K; Tsutsui H; Yoshimoto T; Adachi O; Yoshida N; Kishimoto T ; Okamura H ; Nakanishi K ; Akira S. 1998. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity 8(3):383-90. [PubMed: 9529155] [MGI Ref ID J:46514]

Taneichi M; Naito S; Kato H; Tanaka Y; Mori M; Nakano Y; Yamamura H; Ishida H; Komuro K; Uchida T. 2002. T cell-independent regulation of IgE antibody production induced by surface-linked liposomal antigen. J Immunol 169(8):4246-52. [PubMed: 12370355] [MGI Ref ID J:120172]

Tarrant TK; Silver PB; Chan CC; Wiggert B; Caspi RR. 1998. Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis. J Immunol 161(1):122-7. [PubMed: 9647215] [MGI Ref ID J:119208]

Thomas MJ; Noble A; Sawicka E; Askenase PW; Kemeny DM. 2002. CD8 T cells inhibit IgE via dendritic cell IL-12 induction that promotes Th1 T cell counter-regulation. J Immunol 168(1):216-23. [PubMed: 11751965] [MGI Ref ID J:131005]

Trembleau S; Penna G; Gregori S; Chapman HD; Serreze DV; Magram J; Adorini L. 1999. Pancreas-infiltrating Th1 cells and diabetes develop in IL-12-deficient nonobese diabetic mice. J Immunol 163(5):2960-8. [PubMed: 10453045] [MGI Ref ID J:57084]

Tyznik AJ; Tupin E; Nagarajan NA; Her MJ; Benedict CA; Kronenberg M. 2008. Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals. J Immunol 181(7):4452-6. [PubMed: 18802047] [MGI Ref ID J:141301]

Tzelepis F; Persechini PM; Rodrigues MM. 2007. Modulation of CD4+ T cell-dependent specific cytotoxic CD8+ T cells differentiation and proliferation by the timing of increase in the pathogen load. PLoS ONE 2(4):e393. [PubMed: 17460760] [MGI Ref ID J:129273]

Ueda N; Kuki H; Kamimura D; Sawa S; Seino K; Tashiro T; Fushuku K; Taniguchi M; Hirano T; Murakami M. 2006. CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4. Int Immunol 18(9):1397-404. [PubMed: 16914507] [MGI Ref ID J:113387]

Van Uden JH; Tran CH; Carson DA; Raz E. 2001. Type I interferon is required to mount an adaptive response to immunostimulatory DNA. Eur J Immunol 31(11):3281-90. [PubMed: 11745345] [MGI Ref ID J:72586]

VanLith ML; Kohlgraf KG; Sivinski CL; Tempero RM; Hollingsworth MA. 2002. MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses. Int Immunol 14(8):873-82. [PubMed: 12147624] [MGI Ref ID J:113544]

Vossenkamper A; Struck D; Alvarado-Esquivel C; Went T; Takeda K; Akira S; Pfeffer K; Alber G; Lochner M; Forster I; Liesenfeld O. 2004. Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii, but IL-12 is dominant over IL-18 in parasite control. Eur J Immunol 34(11):3197-207. [PubMed: 15368276] [MGI Ref ID J:93844]

Wang S; Fan Y; Han X; Yang J; Bilenki L; Yang X. 2001. IL-12-dependent vascular cell adhesion molecule-1 expression contributes to airway eosinophilic inflammation in a mouse model of asthma-like reaction. J Immunol 166(4):2741-9. [PubMed: 11160340] [MGI Ref ID J:111001]

Wang SZ; Bao YX; Rosenberger CL; Tesfaigzi Y; Stark JM; Harrod KS. 2004. IL-12p40 and IL-18 modulate inflammatory and immune responses to respiratory syncytial virus infection. J Immunol 173(6):4040-9. [PubMed: 15356153] [MGI Ref ID J:92751]

Wesley JD; Robbins SH; Sidobre S; Kronenberg M; Terrizzi S; Brossay L. 2005. Cutting edge: IFN-gamma signaling to macrophages is required for optimal Valpha14i NK T/NK cell cross-talk. J Immunol 174(7):3864-8. [PubMed: 15778340] [MGI Ref ID J:97977]

Wieland CW; Florquin S; Pater JM; Weijer S; van der Poll T. 2006. CD4+ cells play a limited role in murine lung infection with Mycobacterium kansasii. Am J Respir Cell Mol Biol 34(2):167-73. [PubMed: 16195537] [MGI Ref ID J:120194]

Wigginton JM; Lee JK; Wiltrout TA; Alvord WG; Hixon JA; Subleski J; Back TC; Wiltrout RH. 2002. Synergistic engagement of an ineffective endogenous anti-tumor immune response and induction of IFN-gamma and Fas-ligand-dependent tumor eradication by combined administration of IL-18 and IL-2. J Immunol 169(8):4467-74. [PubMed: 12370382] [MGI Ref ID J:109850]

Wilson MS; Elnekave E; Mentink-Kane MM; Hodges MG; Pesce JT; Ramalingam TR; Thompson RW; Kamanaka M; Flavell RA; Keane-Myers A; Cheever AW; Wynn TA. 2007. IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice. J Clin Invest 117(10):2941-51. [PubMed: 17885690] [MGI Ref ID J:127527]

Wozniak TM; Ryan AA; Britton WJ. 2006. Interleukin-23 restores immunity to Mycobacterium tuberculosis infection in IL-12p40-deficient mice and is not required for the development of IL-17-secreting T cell responses. J Immunol 177(12):8684-92. [PubMed: 17142769] [MGI Ref ID J:140665]

Wuthrich M; Warner T; Klein BS. 2005. IL-12 is required for induction but not maintenance of protective, memory responses to Blastomyces dermatitidis: implications for vaccine development in immune-deficient hosts. J Immunol 175(8):5288-97. [PubMed: 16210634] [MGI Ref ID J:119110]

Xiao BG; Ma CG; Xu LY; Link H; Lu CZ. 2008. IL-12/IFN-gamma/NO axis plays critical role in development of Th1-mediated experimental autoimmune encephalomyelitis. Mol Immunol 45(4):1191-6. [PubMed: 17697713] [MGI Ref ID J:126771]

Xing Z; Zganiacz A; Wang J; Divangahi M; Nawaz F. 2000. IL-12-independent Th1-type immune responses to respiratory viral infection: requirement of IL-18 for IFN-gamma release in the lung but not for the differentiation of viral-reactive Th1-type lymphocytes. J Immunol 164(5):2575-84. [PubMed: 10679096] [MGI Ref ID J:60565]

Yamamoto N; Kawakami K; Kinjo Y; Miyagi K; Kinjo T; Uezu K; Nakasone C; Nakamatsu M; Saito A. 2004. Essential role for the p40 subunit of interleukin-12 in neutrophil-mediated early host defense against pulmonary infection with Streptococcus pneumoniae: involvement of interferon-gamma. Microbes Infect 6(14):1241-9. [PubMed: 15555529] [MGI Ref ID J:105589]

Yap GS; Ortmann R; Shevach E; Sher A. 2001. A heritable defect in IL-12 signaling in B10.Q/J mice. II. Effect on acute resistance to Toxoplasma gondii and rescue by IL-18 treatment. J Immunol 166(9):5720-5. [PubMed: 11313414] [MGI Ref ID J:120304]

Yarovinsky F; Kanzler H; Hieny S; Coffman RL; Sher A. 2006. Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell response. Immunity 25(4):655-64. [PubMed: 17000122] [MGI Ref ID J:114880]

Yi AK; Yoon H; Park JE; Kim BS; Kim HJ; Martinez-Hernandez A. 2006. CpG DNA-mediated induction of acute liver injury in D-galactosamine-sensitized mice: the mitochondrial apoptotic pathway-dependent death of hepatocytes. J Biol Chem 281(21):15001-12. [PubMed: 16554296] [MGI Ref ID J:113473]

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Zelante T; De Luca A; Bonifazi P; Montagnoli C; Bozza S; Moretti S; Belladonna ML; Vacca C; Conte C; Mosci P; Bistoni F; Puccetti P; Kastelein RA; Kopf M; Romani L. 2007. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur J Immunol 37(10):2695-706. [PubMed: 17899546] [MGI Ref ID J:125340]

Zhang JH; He H; Borzychowski AM; Takeda K; Akira S; Croy BA. 2003. Analysis of cytokine regulators inducing interferon production by mouse uterine natural killer cells. Biol Reprod 69(2):404-11. [PubMed: 12646495] [MGI Ref ID J:84561]

Zhang-Hoover J; Sutton A; Stein-Streilein J. 2001. CD40/CD40 ligand interactions are critical for elicitation of autoimmune-mediated fibrosis in the lung. J Immunol 166(5):3556-63. [PubMed: 11207316] [MGI Ref ID J:126400]

van Rossum AM; Lysenko ES; Weiser JN. 2005. Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun 73(11):7718-26. [PubMed: 16239576] [MGI Ref ID J:104292]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports
Room Number AX30

Colony Maintenance

Breeding & Husbandry This strain is maintained by homozygous matings. Expected coat color from breeding:Black

Mating System Homozygote x Homozygote (Female x Male)

Diet Information LabDiet® 5K52/5K67

Breeding & Husbandry	This strain is maintained by homozygous matings. Expected coat color from breeding:Black
Mating System	Homozygote x Homozygote (Female x Male)
Diet Information	LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations

Weeks of Age Price (US dollars $) Gender Genotypes Provided

3-5 weeks $67.50 Female or Male Homozygous for Il12b^tm1Jm

6 weeks $71.40 Female or Male Homozygous for Il12b^tm1Jm

7 weeks $75.30 Female or Male Homozygous for Il12b^tm1Jm

8 weeks $79.20 Female or Male Homozygous for Il12b^tm1Jm

Pairs /Price (US dollars $) Pair Genotype

$142.80 Homozygous for Il12b^tm1Jm x Homozygous for Il12b^tm1Jm

Weeks of Age	Price (US dollars $)	Gender	Genotypes Provided
3-5 weeks	$67.50	Female or Male	Homozygous for Il12b^tm1Jm
6 weeks	$71.40	Female or Male	Homozygous for Il12b^tm1Jm
7 weeks	$75.30	Female or Male	Homozygous for Il12b^tm1Jm
8 weeks	$79.20	Female or Male	Homozygous for Il12b^tm1Jm

Pairs /Price (US dollars $)	Pair Genotype
$142.80	Homozygous for Il12b^tm1Jm x Homozygous for Il12b^tm1Jm

Additional Supply Details

Pricing for International shipping destinations

Weeks of Age Price (US dollars $) Gender Genotypes Provided

3-5 weeks $87.80 Female or Male Homozygous for Il12b^tm1Jm

6 weeks $92.90 Female or Male Homozygous for Il12b^tm1Jm

7 weeks $98.00 Female or Male Homozygous for Il12b^tm1Jm

8 weeks $103.10 Female or Male Homozygous for Il12b^tm1Jm

Pairs /Price (US dollars $) Pair Genotype

$185.70 Homozygous for Il12b^tm1Jm x Homozygous for Il12b^tm1Jm

Weeks of Age	Price (US dollars $)	Gender	Genotypes Provided
3-5 weeks	$87.80	Female or Male	Homozygous for Il12b^tm1Jm
6 weeks	$92.90	Female or Male	Homozygous for Il12b^tm1Jm
7 weeks	$98.00	Female or Male	Homozygous for Il12b^tm1Jm
8 weeks	$103.10	Female or Male	Homozygous for Il12b^tm1Jm

Pairs /Price (US dollars $)	Pair Genotype
$185.70	Homozygous for Il12b^tm1Jm x Homozygous for Il12b^tm1Jm

Additional Supply Details

Supply Details

Standard Supply	Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.
Supply Notes	Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. This strain is included in the Induced Mutant Resource Colony collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	000664 C57BL/6J

Strain Name:

B6.129S1-Il12btm1Jm/J

Stock Number:

002693

Availability:

Level 4

Description

Strain Information

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Phenotype

Phenotype Information

Il12btm1Jm/Il12btm1Jm

Il12btm1Jm/Il12btm1Jm

Il12btm1Jm/Il12btm1Jm

Genes & Alleles

Gene & Allele Information

Genotyping

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Colony Maintenance

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Additional Supply Details

Additional Supply Details

Supply Details

Control Information

B6.129S1-Il12b^tm1Jm/J

Il12b^tm1Jm/Il12b^tm1Jm

Il12b^tm1Jm/Il12b^tm1Jm

Il12b^tm1Jm/Il12b^tm1Jm