Strain Name:

B6.129S1-Il12btm1Jm/J

Stock Number:

002693

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Availability:

Level 4

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Mice homozygous for the Il12btm1Jmtargeted mutation have a severely restricted ability to mount a TH1 response to in vivo endotoxin administration while TH2 response is enhanced. Delayed type hypersensitivity (DTH) responses are reduced.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is an exceptional breeder.
Specieslaboratory mouse
Background Strain C57BL/6
Donor Strain 129S1 via W9.5 ES (+Kitl-SlJ)
GenerationN11F40 (17-SEP-12)
Generation Definitions
 
Donating InvestigatorDr. Jeanne Magram,   Boehringer Ingelheim Pharmaceuticals,Inc

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Related Genotype: a/a

Description
Mice homozygous for the Il12btm1Jmtargeted mutation have a severely restricted ability to mount a TH1 response to in vivo endotoxin administration as evidenced by decreased interferon-gamma production although IL2 (IL-2) production is not compromised. The TH2 response is enhanced as evidenced by increased secretion of IL4 (IL-4). Delayed type hypersensitivity (DTH) responses are reduced. Also see the Il12a-deficient strains (Stock No. 002691 & 002692).

Development
A targeting vector containing a PGK-Neo cassette was used to disrupt part of exon 3. The construct was electroporated into 129S1/Sv-Oca2+ Tyr+ Kitl+ derived W9.5 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6J blastocysts. The mice were backcrossed to C57BL/6 for 9 generations. Upon arrival at The Jackson Laboratory, the mice were crossed to CBA/J (Stock No. 000656) at least once to establish the colony.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Il12btm1Jm allele
002694   C.129S1-Il12btm1Jm/J
019002   CBA.129S1(B6)-Il12btm1Jm/J
View Strains carrying   Il12btm1Jm     (2 strains)

Strains carrying other alleles of Il12b
006412   B6.129-Il12btm1Lky/J
015864   C.129S4(B6)-Il12btm1Lky/J
015863   C.129S4(B6)-Il12btm2Lky/J
009618   NOD.129(B6)-Il12btm1Lky/JbsJ
View Strains carrying other alleles of Il12b     (4 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Asthma, Susceptibility to   (IL12B)
Atypical Mycobacteriosis, Familial   (IL12B)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Il12btm1Jm/Il12btm1Jm

        B6.129S1-Il12btm1Jm/J
  • mortality/aging
  • increased sensitivity to xenobiotic induced morbidity/mortality
    • increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls   (MGI Ref ID J:91927)
  • immune system phenotype
  • abnormal granulocyte physiology
    • fewer than expected granulocytes in the dermis of carcinogen treated skin   (MGI Ref ID J:111568)
  • abnormal lymphocyte physiology
    • lymph node cells from keyhole limpet hemocyanin (KLH) immunized mice are severely impaired in their ability to produce IFNG when cultured with KLH; however, their production of IL4 is increased   (MGI Ref ID J:120806)
    • abnormal CD8-positive T cell physiology
      • dramatic increase in the number of cytotoxic CD8+ cells in the dermis and epidermis of carcinogen treated skin   (MGI Ref ID J:111568)
    • abnormal NK cell physiology
      • mean NK lytic activity is about 66% of controls; however when cultured with IL2 lytic activity is similar to controls   (MGI Ref ID J:120806)
  • abnormal macrophage physiology
    • fewer than expected macrophages in the dermis of carcinogen treated skin   (MGI Ref ID J:111568)
  • decreased circulating interferon-gamma level
    • serum levels of IFNG in LPS-injected mice are only 17 +/- 5% of LPS-induced controls   (MGI Ref ID J:120806)
  • decreased interleukin-17 secretion
    • barely detectable levels of IL17 in the skin after carcinogen treatment unlike wild-type mice which express high levels of IL17   (MGI Ref ID J:111568)
  • decreased susceptibility to type IV hypersensitivity reaction
    • specific foot pad swelling 48 hours after challenge with methylated bovine serum albumin is inhibited by 47 +/- 3% compared to wild-type mice; however, cytotoxic T lymphocyte responses are similar to wild-type   (MGI Ref ID J:120806)
  • increased susceptibility to bacterial infection
    • vaccination does not produce a protective response to M. tuberculosis   (MGI Ref ID J:120806)
  • tumorigenesis
  • decreased incidence of tumors by chemical induction
    • resistant to induction of papillomas compared to wild-type mice after treatment with DMBA and TPA in a 2 step skin carcinogenesis protocol   (MGI Ref ID J:111568)
    • however, there is an increase in the incidence of tumors following intradermal challenge with PDV squamous carcinoma cells   (MGI Ref ID J:111568)
  • homeostasis/metabolism phenotype
  • decreased circulating interferon-gamma level
    • serum levels of IFNG in LPS-injected mice are only 17 +/- 5% of LPS-induced controls   (MGI Ref ID J:120806)
  • decreased incidence of tumors by chemical induction
    • resistant to induction of papillomas compared to wild-type mice after treatment with DMBA and TPA in a 2 step skin carcinogenesis protocol   (MGI Ref ID J:111568)
    • however, there is an increase in the incidence of tumors following intradermal challenge with PDV squamous carcinoma cells   (MGI Ref ID J:111568)
  • increased sensitivity to xenobiotic induced morbidity/mortality
    • increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls   (MGI Ref ID J:91927)
  • craniofacial phenotype
  • abnormal alveolar process morphology
    • 3 fold increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks   (MGI Ref ID J:147935)
  • skeleton phenotype
  • abnormal alveolar process morphology
    • 3 fold increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks   (MGI Ref ID J:147935)
  • hematopoietic system phenotype
  • abnormal granulocyte physiology
    • fewer than expected granulocytes in the dermis of carcinogen treated skin   (MGI Ref ID J:111568)
  • abnormal lymphocyte physiology
    • lymph node cells from keyhole limpet hemocyanin (KLH) immunized mice are severely impaired in their ability to produce IFNG when cultured with KLH; however, their production of IL4 is increased   (MGI Ref ID J:120806)
    • abnormal CD8-positive T cell physiology
      • dramatic increase in the number of cytotoxic CD8+ cells in the dermis and epidermis of carcinogen treated skin   (MGI Ref ID J:111568)
    • abnormal NK cell physiology
      • mean NK lytic activity is about 66% of controls; however when cultured with IL2 lytic activity is similar to controls   (MGI Ref ID J:120806)
  • abnormal macrophage physiology
    • fewer than expected macrophages in the dermis of carcinogen treated skin   (MGI Ref ID J:111568)

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Il12btm1Jm/Il12btm1Jm

        129S1/Sv-Il12btm1Jm
  • immune system phenotype
  • abnormal CD4-positive T cell physiology
    • 75 days after infection Ifng mRNA expression in CD4+ cells is more than 50-fold lower than in wild-type   (MGI Ref ID J:34164)
    • 75 days after infection Il4 mRNA expression in CD4+ cells is 100-fold higher than in wild-type   (MGI Ref ID J:34164)
    • draining lymph node cells in L. major infected mice produce significantly more IL4 compared to IFNG in contrast to wild-type mice which express more IFNG than IL4   (MGI Ref ID J:34164)
  • decreased susceptibility to type IV hypersensitivity reaction
    • do not show any delayed type hypersensitivity response to application of Leishmania antigen to the uninfected footpad 41 days after initial infection with L. major   (MGI Ref ID J:34164)
  • increased susceptibility to parasitic infection
    • develop large lesions unlike wild-type 129S1/Sv mice after infection with Leishmania major   (MGI Ref ID J:34164)
    • 75 days after infection with L. major parasite numbers in the draining lymph nodes are increased 400-fold compared to wild-type mice   (MGI Ref ID J:34164)
  • hematopoietic system phenotype
  • abnormal CD4-positive T cell physiology
    • 75 days after infection Ifng mRNA expression in CD4+ cells is more than 50-fold lower than in wild-type   (MGI Ref ID J:34164)
    • 75 days after infection Il4 mRNA expression in CD4+ cells is 100-fold higher than in wild-type   (MGI Ref ID J:34164)
    • draining lymph node cells in L. major infected mice produce significantly more IL4 compared to IFNG in contrast to wild-type mice which express more IFNG than IL4   (MGI Ref ID J:34164)

Il12btm1Jm/Il12btm1Jm

        involves: 129S1/SvImJ
  • immune system phenotype
  • abnormal T-helper 1 physiology
    • in vivo Th1 cell response is impaired as indicated by the low amounts of IFN-gamma produced by T cells in response to M. bovis antigens   (MGI Ref ID J:46514)
  • decreased interferon-gamma secretion
    • splenic T cells produce about 1/4th the amount of IFN-gamma as T cells from wild-type mice 14 days after injection with heat killed M. Bovis   (MGI Ref ID J:46514)
  • impaired natural killer cell mediated cytotoxicity
    • the killing activity of splenic NK cells is about 2/3rds that of wild-type mice as measured by in vitro co-culturing with YAC-1 target cells   (MGI Ref ID J:46514)
    • normal level of target cell killing can be restored by in vivo pretreatment with IL-18 for two days or the addition of IL-18 to the co-culture   (MGI Ref ID J:46514)
  • hematopoietic system phenotype
  • abnormal T-helper 1 physiology
    • in vivo Th1 cell response is impaired as indicated by the low amounts of IFN-gamma produced by T cells in response to M. bovis antigens   (MGI Ref ID J:46514)
  • impaired natural killer cell mediated cytotoxicity
    • the killing activity of splenic NK cells is about 2/3rds that of wild-type mice as measured by in vitro co-culturing with YAC-1 target cells   (MGI Ref ID J:46514)
    • normal level of target cell killing can be restored by in vivo pretreatment with IL-18 for two days or the addition of IL-18 to the co-culture   (MGI Ref ID J:46514)

Il12btm1Jm/Il12btm1Jm

        involves: 129S1/Sv
  • mortality/aging
  • increased susceptibility to bacterial infection induced morbidity/mortality
    • mice died before day 12 after inoculation with C. rodentium   (MGI Ref ID J:161073)
  • immune system phenotype
  • increased susceptibility to bacterial infection induced morbidity/mortality
    • mice died before day 12 after inoculation with C. rodentium   (MGI Ref ID J:161073)
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Research Applications
This mouse can be used to support research in many areas including:

Il12btm1Jm related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Il12btm1Jm
Allele Name targeted mutation 1, Jeanne Magram
Allele Type Targeted (knock-out)
Common Name(s) IL-12 p40-; IL-12-; IL-12KO; IL-12btm1 Jm; IL-12p40-; IL-12p40-KO; IL12p40-; Il-12/23p40 KO; Il12b-; p40-;
Mutation Made ByDr. Jeanne Magram,   Boehringer Ingelheim Pharmaceuticals,Inc
Strain of Origin129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
ES Cell Line NameW9.5/W95
ES Cell Line Strain129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Gene Symbol and Name Il12b, interleukin 12b
Chromosome 11
Gene Common Name(s) CLMF; CLMF2; IL-12 p40; IL-12B; IL-23 subunit p40; Il-12b; Il-12p40; Il12; NKSF; NKSF2;
Molecular Note A neomycin resistance cassette replaced a portion of exon 3 of the gene. [MGI Ref ID J:33141]

Genotyping

Genotyping Information

Genotyping Protocols

Il12btm1Jmalternate2, Separated PCR
NntC57BL/6J,

Separated MCA


Il12btm1Jm, Separated PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Magram J; Connaughton SE; Warrier RR; Carvajal DM; Wu CY; Ferrante J; Stewart C; Sarmiento U; Faherty DA; Gately MK. 1996. IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity 4(5):471-81. [PubMed: 8630732]  [MGI Ref ID J:33141]

Additional References

Chang J; Cho JH; Lee SW; Choi SY; Ha SJ; Sung YC. 2004. IL-12 priming during in vitro antigenic stimulation changes properties of CD8 T cells and increases generation of effector and memory cells. J Immunol 172(5):2818-26. [PubMed: 14978082]  [MGI Ref ID J:88236]

Cooper AM; Magram J; Ferrante J; Orme IM. 1997. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis. J Exp Med 186(1):39-45. [PubMed: 9206995]  [MGI Ref ID J:41494]

Cua DJ; Sherlock J; Chen Y; Murphy CA; Joyce B; Seymour B; Lucian L; To W; Kwan S; Churakova T; Zurawski S; Wiekowski M; Lira SA; Gorman D; Kastelein RA; Sedgwick JD. 2003. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421(6924):744-8. [PubMed: 12610626]  [MGI Ref ID J:89968]

Ghilardi N; Kljavin N; Chen Q; Lucas S; Gurney AL; De Sauvage FJ. 2004. Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J Immunol 172(5):2827-33. [PubMed: 14978083]  [MGI Ref ID J:88235]

Hayashi T; Rao SP; Takabayashi K; Van Uden JH; Kornbluth RS; Baird SM; Taylor MW; Carson DA; Catanzaro A; Raz E. 2001. Enhancement of Innate Immunity against Mycobacterium avium Infection by Immunostimulatory DNA Is Mediated by Indoleamine 2,3-Dioxygenase. Infect Immun 69(10):6156-64. [PubMed: 11553555]  [MGI Ref ID J:71646]

Hazlett LD; Rudner XL; McClellan SA; Barrett RP; Lighvani S. 2002. Role of IL-12 and IFN-gamma in Pseudomonas aeruginosa corneal infection. Invest Ophthalmol Vis Sci 43(2):419-24. [PubMed: 11818386]  [MGI Ref ID J:74264]

Kawakami K; Kinjo Y; Yara S; Uezu K; Koguchi Y; Tohyama M; Azuma M; Takeda K; Akira S; Saito A. 2001. Enhanced Gamma Interferon Production through Activation of Valpha14(+) Natural Killer T Cells by alpha-Galactosylceramide in Interleukin-18-Deficient Mice with Systemic Cryptococcosis. Infect Immun 69(11):6643-50. [PubMed: 11598033]  [MGI Ref ID J:72191]

Ko J; Gendron-Fitzpatrick A; Splitter GA. 2002. Susceptibility of IFN regulatory factor-1 and IFN consensus sequence binding protein-deficient mice to brucellosis. J Immunol 168(5):2433-40. [PubMed: 11859135]  [MGI Ref ID J:74725]

Li L; Hsu HC; Stockard CR; Yang P; Zhou J; Wu Q; Grizzle WE; Mountz JD. 2004. IL-12 inhibits thymic involution by enhancing IL-7- and IL-2-induced thymocyte proliferation. J Immunol 172(5):2909-16. [PubMed: 14978093]  [MGI Ref ID J:88230]

Mattner F; Magram J; Ferrante J; Launois P; Di Padova K; Behin R; Gately MK; Louis JA; Alber G. 1996. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur J Immunol 26(7):1553-9. [PubMed: 8766560]  [MGI Ref ID J:34164]

McIntyre KW; Shuster DJ; Gillooly KM; Warrier RR; Connaughton SE ; Hall LB ; Arp LH ; Gately MK ; Magram J. 1996. Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice. Eur J Immunol 26(12):2933-8. [PubMed: 8977288]  [MGI Ref ID J:37075]

Nguyen KB; Salazar-Mather TP; Dalod MY; Van Deusen JB; Wei XQ; Liew FY; Caligiuri MA; Durbin JE; Biron CA. 2002. Coordinated and distinct roles for IFN-alphabeta, IL-12, and IL-15 regulation of NK cell responses to viral infection. J Immunol 169(8):4279-87. [PubMed: 12370359]  [MGI Ref ID J:79552]

Piccotti JR; Li K; Chan SY; Ferrante J; Magram J; Eichwald EJ; Bishop DK. 1998. Alloantigen-reactive Th1 development in IL-12-deficient mice. J Immunol 160(3):1132-8. [PubMed: 9570526]  [MGI Ref ID J:90552]

Pien GC; Nguyen KB; Malmgaard L; Satoskar AR; Biron CA. 2002. A unique mechanism for innate cytokine promotion of T cell responses to viral infections. J Immunol 169(10):5827-37. [PubMed: 12421964]  [MGI Ref ID J:80075]

Van Uden JH; Tran CH; Carson DA; Raz E. 2001. Type I interferon is required to mount an adaptive response to immunostimulatory DNA. Eur J Immunol 31(11):3281-90. [PubMed: 11745345]  [MGI Ref ID J:72586]

Il12btm1Jm related

Adachi K; Tsutsui H; Kashiwamura S; Seki E; Nakano H; Takeuchi O; Takeda K; Okumura K; Van Kaer L; Okamura H; Akira S; Nakanishi K. 2001. Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism. J Immunol 167(10):5928-34. [PubMed: 11698470]  [MGI Ref ID J:118004]

Akhiani AA; Pappo J; Kabok Z; Schon K; Gao W; Franzen LE; Lycke N. 2002. Protection against Helicobacter pylori infection following immunization is IL-12-dependent and mediated by Th1 cells. J Immunol 169(12):6977-84. [PubMed: 12471132]  [MGI Ref ID J:118009]

Alayan J; Ivanovski S; Farah CS. 2007. Alveolar bone loss in T helper 1/T helper 2 cytokine-deficient mice. J Periodontal Res 42(2):97-103. [PubMed: 17305866]  [MGI Ref ID J:147935]

Aliberti J; Viola JP; Vieira-de-Abreu A; Bozza PT; Sher A; Scharfstein J. 2003. Cutting edge: Bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization. J Immunol 170(11):5349-53. [PubMed: 12759407]  [MGI Ref ID J:83453]

Amprey JL; Im JS; Turco SJ; Murray HW; Illarionov PA; Besra GS; Porcelli SA; Spath GF. 2004. A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan. J Exp Med 200(7):895-904. [PubMed: 15466622]  [MGI Ref ID J:93947]

Anderson S; Shires VL; Wilson RA; Mountford AP. 1999. Formation of multinucleated giant cells in the mouse lung is promoted in the absence of interleukin-12. Am J Respir Cell Mol Biol 20(3):371-8. [PubMed: 10030834]  [MGI Ref ID J:114254]

Ariga H; Shimohakamada Y; Nakada M; Tokunaga T; Kikuchi T; Kariyone A; Tamura T; Takatsu K. 2007. Instruction of naive CD4+ T-cell fate to T-bet expression and T helper 1 development: roles of T-cell receptor-mediated signals. Immunology 122(2):210-21. [PubMed: 17490433]  [MGI Ref ID J:125688]

Askenase PW; Itakura A; Leite-de-Moraes MC; Lisbonne M; Roongapinun S; Goldstein DR; Szczepanik M. 2005. TLR-dependent IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo. J Immunol 175(10):6390-401. [PubMed: 16272291]  [MGI Ref ID J:119381]

Awoniyi M; Miller SI; Wilson CB; Hajjar AM; Smith KD. 2012. Homeostatic regulation of Salmonella-induced mucosal inflammation and injury by IL-23. PLoS One 7(5):e37311. [PubMed: 22624013]  [MGI Ref ID J:187224]

Baird JR; Fox BA; Sanders KL; Lizotte PH; Cubillos-Ruiz JR; Scarlett UK; Rutkowski MR; Conejo-Garcia JR; Fiering S; Bzik DJ. 2013. Avirulent Toxoplasma gondii Generates Therapeutic Antitumor Immunity by Reversing Immunosuppression in the Ovarian Cancer Microenvironment. Cancer Res 73(13):3842-51. [PubMed: 23704211]  [MGI Ref ID J:199114]

Barkhuizen M; Magez S; Atkinson RA; Brombacher F. 2007. Interleukin-12p70-dependent interferon- gamma production is crucial for resistance in African trypanosomiasis. J Infect Dis 196(8):1253-60. [PubMed: 17955445]  [MGI Ref ID J:145097]

Barr DP; Belz GT; Reading PC; Wojtasiak M; Whitney PG; Heath WR; Carbone FR; Brooks AG. 2007. A role for plasmacytoid dendritic cells in the rapid IL-18-dependent activation of NK cells following HSV-1 infection. Eur J Immunol 37(5):1334-42. [PubMed: 17407097]  [MGI Ref ID J:123560]

Bastos KR; Alvarez JM; Marinho CR; Rizzo LV; Lima MR. 2002. Macrophages from IL-12p40-deficient mice have a bias toward the M2 activation profile. J Leukoc Biol 71(2):271-8. [PubMed: 11818448]  [MGI Ref ID J:74693]

Bastos KR; de Deus Vieira de Moraes L; Zago CA; Marinho CR; Russo M; Alvarez JM; D'Imperio Lima MR. 2005. Analysis of the activation profile of dendritic cells derived from the bone marrow of interleukin-12/interleukin-23-deficient mice. Immunology 114(4):499-506. [PubMed: 15804287]  [MGI Ref ID J:97435]

Beattie L; Svensson M; Bune A; Brown N; Maroof A; Zubairi S; Smith KR; Kaye PM. 2010. Leishmania donovani-induced expression of signal regulatory protein alpha on Kupffer cells enhances hepatic invariant NKT-cell activation. Eur J Immunol 40(1):117-23. [PubMed: 19877019]  [MGI Ref ID J:155693]

Becher B; Durell BG; Noelle RJ. 2002. Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J Clin Invest 110(4):493-7. [PubMed: 12189243]  [MGI Ref ID J:78574]

Beenhouwer DO; Shapiro S; Feldmesser M; Casadevall A; Scharff MD. 2001. Both Th1 and Th2 Cytokines Affect the Ability of Monoclonal Antibodies To Protect Mice against Cryptococcus neoformans. Infect Immun 69(10):6445-55. [PubMed: 11553589]  [MGI Ref ID J:71570]

Belz GT; Bedoui S; Kupresanin F; Carbone FR; Heath WR. 2007. Minimal activation of memory CD8(+) T cell by tissue-derived dendritic cells favors the stimulation of naive CD8(+) T cells. Nat Immunol 8(10):1060-6. [PubMed: 17767161]  [MGI Ref ID J:125274]

Blazar BR; Lees CJ; Martin PJ; Noelle RJ; Kwon B; Murphy W; Taylor PA. 2000. Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions. J Immunol 165(9):4901-9. [PubMed: 11046015]  [MGI Ref ID J:118027]

Boelen A; Kwakkel J; Platvoet-ter Schiphorst M; Baur A; Kohrle J; Wiersinga WM. 2004. Contribution of interleukin-12 to the pathogenesis of non-thyroidal illness. Horm Metab Res 36(2):101-6. [PubMed: 15002060]  [MGI Ref ID J:120558]

Bombeiro AL; Goncalves LA; Penha-Goncalves C; Marinho CR; D'Imperio Lima MR; Chadi G; Alvarez JM. 2012. IL-12p40 deficiency leads to uncontrolled Trypanosoma cruzi dissemination in the spinal cord resulting in neuronal death and motor dysfunction. PLoS One 7(11):e49022. [PubMed: 23152844]  [MGI Ref ID J:195025]

Brigl M; Tatituri RV; Watts GF; Bhowruth V; Leadbetter EA; Barton N; Cohen NR; Hsu FF; Besra GS; Brenner MB. 2011. Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection. J Exp Med 208(6):1163-77. [PubMed: 21555485]  [MGI Ref ID J:177293]

Brummel R; Roberts TL; Stacey KJ; Lenert P. 2006. Higher-order CpG-DNA stimulation reveals distinct activation requirements for marginal zone and follicular B cells in lupus mice. Eur J Immunol 36(7):1951-62. [PubMed: 16791898]  [MGI Ref ID J:115797]

Burt BM; Plitas G; Stableford JA; Nguyen HM; Bamboat ZM; Pillarisetty VG; DeMatteo RP. 2008. CD11c identifies a subset of murine liver natural killer cells that responds to adenoviral hepatitis. J Leukoc Biol 84(4):1039-46. [PubMed: 18664530]  [MGI Ref ID J:140218]

Buxbaum LU; Denise H; Coombs GH; Alexander J; Mottram JC; Scott P. 2003. Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity. J Immunol 171(7):3711-7. [PubMed: 14500670]  [MGI Ref ID J:120395]

Buxbaum LU; Uzonna JE; Goldschmidt MH; Scott P. 2002. Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent. Eur J Immunol 32(11):3206-15. [PubMed: 12555666]  [MGI Ref ID J:115538]

Camoglio L; Juffermans NP; Peppelenbosch M; te Velde AA; ten Kate FJ; van Deventer SJ; Kopf M. 2002. Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis. Eur J Immunol 32(1):261-9. [PubMed: 11782017]  [MGI Ref ID J:73931]

Carlow DA; Williams MJ; Ziltener HJ. 2005. Inducing P-selectin ligand formation in CD8 T cells: IL-2 and IL-12 are active in vitro but not required in vivo. J Immunol 174(7):3959-66. [PubMed: 15778352]  [MGI Ref ID J:110004]

Case LK; Petell L; Yurkovetskiy L; Purdy A; Savage KJ; Golovkina TV. 2008. Replication of beta- and gammaretroviruses is restricted in I/LnJ mice via the same genetic mechanism. J Virol 82(3):1438-47. [PubMed: 18057254]  [MGI Ref ID J:163153]

Castilow EM; Legge KL; Varga SM. 2008. Cutting edge: Eosinophils do not contribute to respiratory syncytial virus vaccine-enhanced disease. J Immunol 181(10):6692-6. [PubMed: 18981084]  [MGI Ref ID J:140954]

Cenci E; Mencacci A; Del Sero G; Bacci A; Montagnoli C; d'Ostiani CF; Mosci P; Bachmann M; Bistoni F; Kopf M; Romani L. 1999. Interleukin-4 causes susceptibility to invasive pulmonary aspergillosis through suppression of protective type I responses. J Infect Dis 180(6):1957-68. [PubMed: 10558953]  [MGI Ref ID J:119841]

Chackerian AA; Chen SJ; Brodie SJ; Mattson JD; McClanahan TK; Kastelein RA; Bowman EP. 2006. Neutralization or absence of the interleukin-23 pathway does not compromise immunity to mycobacterial infection. Infect Immun 74(11):6092-9. [PubMed: 16923792]  [MGI Ref ID J:113448]

Chakraborty K; Zhou Z; Wakamatsu N; Guerrero-Plata A. 2012. Interleukin-12p40 modulates human metapneumovirus-induced pulmonary disease in an acute mouse model of infection. PLoS One 7(5):e37173. [PubMed: 22606349]  [MGI Ref ID J:187243]

Chan YR; Liu JS; Pociask DA; Zheng M; Mietzner TA; Berger T; Mak TW; Clifton MC; Strong RK; Ray P; Kolls JK. 2009. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J Immunol 182(8):4947-56. [PubMed: 19342674]  [MGI Ref ID J:147498]

Chang J; Cho JH; Lee SW; Choi SY; Ha SJ; Sung YC. 2004. IL-12 priming during in vitro antigenic stimulation changes properties of CD8 T cells and increases generation of effector and memory cells. J Immunol 172(5):2818-26. [PubMed: 14978082]  [MGI Ref ID J:88236]

Chang JT; Shevach EM; Segal BM. 1999. Regulation of interleukin (IL)-12 receptor beta2 subunit expression by endogenous IL-12: a critical step in the differentiation of pathogenic autoreactive T cells. J Exp Med 189(6):969-78. [PubMed: 10075980]  [MGI Ref ID J:53619]

Chen K; Wei Y; Sharp GC; Braley-Mullen H. 2001. Induction of experimental autoimmune thyroiditis in IL-12-/- mice. J Immunol 167(3):1720-7. [PubMed: 11466396]  [MGI Ref ID J:120397]

Chen L; Lei L; Zhou Z; He J; Xu S; Lu C; Chen J; Yang Z; Wu G; Yeh IT; Zhong G; Wu Y. 2013. Contribution of interleukin-12 p35 (IL-12p35) and IL-12p40 to protective immunity and pathology in mice infected with Chlamydia muridarum. Infect Immun 81(8):2962-71. [PubMed: 23753624]  [MGI Ref ID J:199835]

Chiaramonte MG; Hesse M; Cheever AW; Wynn TA. 2000. CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism. J Immunol 164(2):973-85. [PubMed: 10623847]  [MGI Ref ID J:127058]

Chiaramonte MG; Mentink-Kane M; Jacobson BA; Cheever AW; Whitters MJ; Goad ME; Wong A; Collins M; Donaldson DD; Grusby MJ; Wynn TA. 2003. Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. J Exp Med 197(6):687-701. [PubMed: 12642601]  [MGI Ref ID J:124413]

Chiodoni C; Stoppacciaro A; Sangaletti S; Gri G; Cappetti B; Koezuka Y; Colombo MP. 2001. Different requirements for alpha-galactosylceramide and recombinant IL-12 antitumor activity in the treatment of C-26 colon carcinoma hepatic metastases. Eur J Immunol 31(10):3101-10. [PubMed: 11592087]  [MGI Ref ID J:115631]

Cho JS; Pietras EM; Garcia NC; Ramos RI; Farzam DM; Monroe HR; Magorien JE; Blauvelt A; Kolls JK; Cheung AL; Cheng G; Modlin RL; Miller LS. 2010. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest 120(5):1762-73. [PubMed: 20364087]  [MGI Ref ID J:161481]

Chua WJ; Truscott SM; Eickhoff CS; Blazevic A; Hoft DF; Hansen TH. 2012. Polyclonal mucosa-associated invariant T cells have unique innate functions in bacterial infection. Infect Immun 80(9):3256-67. [PubMed: 22778103]  [MGI Ref ID J:187169]

Cobb D; Smeltz RB. 2012. Regulation of proinflammatory Th17 responses during Trypanosoma cruzi infection by IL-12 family cytokines. J Immunol 188(8):3766-73. [PubMed: 22412196]  [MGI Ref ID J:184072]

Coers J; Vance RE; Fontana MF; Dietrich WF. 2007. Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways. Cell Microbiol 9(10):2344-57. [PubMed: 17506816]  [MGI Ref ID J:148669]

Cooper AM; Kipnis A; Turner J; Magram J; Ferrante J; Orme IM. 2002. Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present. J Immunol 168(3):1322-7. [PubMed: 11801672]  [MGI Ref ID J:73949]

Cooper AM; Magram J; Ferrante J; Orme IM. 1997. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis. J Exp Med 186(1):39-45. [PubMed: 9206995]  [MGI Ref ID J:41494]

Crow AR; Song S; Semple JW; Freedman J; Lazarus AH. 2007. A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg? Blood 109(1):155-8. [PubMed: 16954498]  [MGI Ref ID J:142178]

Croy BA; Ashkar AA; Foster RA; DiSanto JP; Magram J; Carson D; Gendler SJ; Grusby MJ; Wagner N; Muller W; Guimond MJ. 1997. Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy J Reprod Immunol 35(2):111-33. [PubMed: 9421796]  [MGI Ref ID J:44813]

Cua DJ; Sherlock J; Chen Y; Murphy CA; Joyce B; Seymour B; Lucian L; To W; Kwan S; Churakova T; Zurawski S; Wiekowski M; Lira SA; Gorman D; Kastelein RA; Sedgwick JD. 2003. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421(6924):744-8. [PubMed: 12610626]  [MGI Ref ID J:89968]

Davenport P; Tipping PG. 2003. The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice. Am J Pathol 163(3):1117-25. [PubMed: 12937153]  [MGI Ref ID J:85172]

DePaolo RW; Abadie V; Tang F; Fehlner-Peach H; Hall JA; Wang W; Marietta EV; Kasarda DD; Waldmann TA; Murray JA; Semrad C; Kupfer SS; Belkaid Y; Guandalini S; Jabri B. 2011. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature 471(7337):220-4. [PubMed: 21307853]  [MGI Ref ID J:170338]

Denton AE; Doherty PC; Turner SJ; La Gruta NL. 2007. IL-18, but not IL-12, is required for optimal cytokine production by influenza virus-specific CD8(+) T cells. Eur J Immunol 37(2):368-75. [PubMed: 17219365]  [MGI Ref ID J:117879]

Dohi T; Fujihashi K; Kiyono H; Elson CO; McGhee JR. 2000. Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis. Gastroenterology 119(3):724-33. [PubMed: 10982767]  [MGI Ref ID J:64230]

Dokun AO; Chu DT; Yang L; Bendelac AS; Yokoyama WM. 2001. Analysis of in situ NK cell responses during viral infection. J Immunol 167(9):5286-93. [PubMed: 11673544]  [MGI Ref ID J:72673]

Dong H; Franklin NA; Roberts DJ; Yagita H; Glennie MJ; Bullock TN. 2012. CD27 stimulation promotes the frequency of IL-7 receptor-expressing memory precursors and prevents IL-12-mediated loss of CD8(+) T cell memory in the absence of CD4(+) T cell help. J Immunol 188(8):3829-38. [PubMed: 22422886]  [MGI Ref ID J:184064]

Doodes PD; Cao Y; Hamel KM; Wang Y; Farkas B; Iwakura Y; Finnegan A. 2008. Development of proteoglycan-induced arthritis is independent of IL-17. J Immunol 181(1):329-37. [PubMed: 18566398]  [MGI Ref ID J:137406]

Doolan DL; Hoffman SL. 1999. IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii model. J Immunol 163(2):884-92. [PubMed: 10395683]  [MGI Ref ID J:119784]

Dudakov JA; Hanash AM; Jenq RR; Young LF; Ghosh A; Singer NV; West ML; Smith OM; Holland AM; Tsai JJ; Boyd RL; van den Brink MR. 2012. Interleukin-22 drives endogenous thymic regeneration in mice. Science 336(6077):91-5. [PubMed: 22383805]  [MGI Ref ID J:182233]

Duhen R; Glatigny S; Arbelaez CA; Blair TC; Oukka M; Bettelli E. 2013. Cutting Edge: The Pathogenicity of IFN-gamma-Producing Th17 Cells Is Independent of T-bet. J Immunol 190(9):4478-82. [PubMed: 23543757]  [MGI Ref ID J:195506]

Dumoutier L; de Heusch M; Orabona C; Satoh-Takayama N; Eberl G; Sirard JC; Di Santo JP; Renauld JC. 2011. IL-22 is produced by gammaC-independent CD25+ CCR6+ innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality. Eur J Immunol 41(4):1075-85. [PubMed: 21400499]  [MGI Ref ID J:175417]

Duthie MS; Kahn M; White M; Kapur RP; Kahn SJ. 2005. Both CD1d antigen presentation and interleukin-12 are required to activate natural killer T cells during Trypanosoma cruzi infection. Infect Immun 73(3):1890-4. [PubMed: 15731095]  [MGI Ref ID J:96678]

Eberl G; Brawand P; MacDonald HR. 2000. Selective bystander proliferation of memory CD4+ and CD8+ T cells upon NK T or T cell activation. J Immunol 165(8):4305-11. [PubMed: 11035065]  [MGI Ref ID J:119149]

Ehigiator HN; Romagnoli P; Borgelt K; Fernandez M; McNair N; Secor WE; Mead JR. 2005. Mucosal cytokine and antigen-specific responses to Cryptosporidium parvum in IL-12p40 KO mice. Parasite Immunol 27(1-2):17-28. [PubMed: 15813719]  [MGI Ref ID J:110161]

Ehl S; Bischoff R; Ostler T; Vallbracht S; Schulte-Monting J; Poltorak A; Freudenberg M. 2004. The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus. Eur J Immunol 34(4):1146-53. [PubMed: 15048726]  [MGI Ref ID J:88878]

Ely KH; Kasper LH; Khan IA. 1999. Augmentation of the CD8+ T cell response by IFN-gamma in IL-12-deficient mice during Toxoplasma gondii infection. J Immunol 162(9):5449-54. [PubMed: 10228024]  [MGI Ref ID J:111011]

Eriksson U; Kurrer MO; Sebald W; Brombacher F; Kopf M. 2001. Dual role of the IL-12/IFN-gamma axis in the development of autoimmune myocarditis: induction by IL-12 and protection by IFN-gamma. J Immunol 167(9):5464-9. [PubMed: 11673566]  [MGI Ref ID J:72665]

Ertelt JM; Johanns TM; Rowe JH; Way SS. 2010. Interleukin (IL)-21-independent pathogen-specific CD8+ T-cell expansion, and IL-21-dependent suppression of CD4+ T-cell IL-17 production. Immunology 131(2):183-91. [PubMed: 20465570]  [MGI Ref ID J:166404]

Esche C; Gambotto A; Satoh Y; Gerein V; Robbins PD; Watkins SC; Lotze MT; Shurin MR. 1999. CD154 inhibits tumor-induced apoptosis in dendritic cells and tumor growth. Eur J Immunol 29(7):2148-55. [PubMed: 10427977]  [MGI Ref ID J:115301]

Farah CS; Hu Y; Riminton S; Ashman RB. 2006. Distinct roles for interleukin-12p40 and tumour necrosis factor in resistance to oral candidiasis defined by gene-targeting. Oral Microbiol Immunol 21(4):252-5. [PubMed: 16842510]  [MGI Ref ID J:136489]

Fauconnier M; Palomo J; Bourigault ML; Meme S; Szeremeta F; Beloeil JC; Danneels A; Charron S; Rihet P; Ryffel B; Quesniaux VF. 2012. IL-12Rbeta2 is essential for the development of experimental cerebral malaria. J Immunol 188(4):1905-14. [PubMed: 22238458]  [MGI Ref ID J:181195]

Feng CG; Jankovic D; Kullberg M; Cheever A; Scanga CA; Hieny S; Caspar P; Yap GS; Sher A. 2005. Maintenance of pulmonary Th1 effector function in chronic tuberculosis requires persistent IL-12 production. J Immunol 174(7):4185-92. [PubMed: 15778379]  [MGI Ref ID J:97935]

Feng CG; Kaviratne M; Rothfuchs AG; Cheever A; Hieny S; Young HA; Wynn TA; Sher A. 2006. NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis. J Immunol 177(10):7086-93. [PubMed: 17082625]  [MGI Ref ID J:140483]

Fischer R; Tome D; McGhee JR; Boyaka PN. 2007. Th1 and Th2 cells are required for both eosinophil- and neutrophil-associated airway inflammatory responses in mice. Biochem Biophys Res Commun 357(1):44-9. [PubMed: 17412309]  [MGI Ref ID J:121793]

Florido M; Pearl JE; Solache A; Borges M; Haynes L; Cooper AM; Appelberg R. 2005. Gamma interferon-induced T-cell loss in virulent Mycobacterium avium infection. Infect Immun 73(6):3577-86. [PubMed: 15908387]  [MGI Ref ID J:99143]

Fortier A; Doiron K; Saleh M; Grinstein S; Gros P. 2009. Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4. Infect Immun 77(11):4794-805. [PubMed: 19720760]  [MGI Ref ID J:154191]

Frank GM; Divito SJ; Maker DM; Xu M; Hendricks RL. 2010. A novel p40-independent function of IL-12p35 is required for progression and maintenance of herpes stromal keratitis. Invest Ophthalmol Vis Sci 51(7):3591-8. [PubMed: 20207959]  [MGI Ref ID J:164098]

Freudenberg MA; Merlin T; Kalis C; Chvatchko Y; Stubig H; Galanos C. 2002. Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling. J Immunol 169(4):1665-8. [PubMed: 12165484]  [MGI Ref ID J:120706]

Galvao Da Silva AP; Jacysyn JF; De Almeida Abrahamsohn I. 2003. Resistant mice lacking interleukin-12 become susceptible to Trypanosoma cruzi infection but fail to mount a T helper type 2 response. Immunology 108(2):230-7. [PubMed: 12562332]  [MGI Ref ID J:82090]

Ghilardi N; Kljavin N; Chen Q; Lucas S; Gurney AL; De Sauvage FJ. 2004. Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J Immunol 172(5):2827-33. [PubMed: 14978083]  [MGI Ref ID J:88235]

Gill N; Chenoweth MJ; Verdu EF; Ashkar AA. 2011. NK cells require type I IFN receptor for antiviral responses during genital HSV-2 infection. Cell Immunol 269(1):29-37. [PubMed: 21477795]  [MGI Ref ID J:172288]

Gorbachev AV; Fairchild RL. 2004. CD40 engagement enhances antigen-presenting langerhans cell priming of IFN-gamma-producing CD4+ and CD8+ T cells independently of IL-12. J Immunol 173(4):2443-52. [PubMed: 15294958]  [MGI Ref ID J:92689]

Graefe SE; Jacobs T; Gaworski I; Klauenberg U; Steeg C; Fleischer B. 2003. Interleukin-12 but not interleukin-18 is required for immunity to Trypanosoma cruzi in mice. Microbes Infect 5(10):833-9. [PubMed: 12919851]  [MGI Ref ID J:106010]

Gramaglia I; Sahlin H; Nolan JP; Frangos JA; Intaglietta M; van der Heyde HC. 2005. Cell- rather than antibody-mediated immunity leads to the development of profound thrombocytopenia during experimental Plasmodium berghei malaria. J Immunol 175(11):7699-707. [PubMed: 16301680]  [MGI Ref ID J:122163]

Gran B; Zhang GX; Yu S; Li J; Chen XH; Ventura ES; Kamoun M; Rostami A. 2002. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J Immunol 169(12):7104-10. [PubMed: 12471147]  [MGI Ref ID J:118415]

Gupta S; Boppana R; Mishra GC; Saha B; Mitra D. 2008. Interleukin-12 is necessary for the priming of CD4+ T cells required during the elicitation of HIV-1 gp120-specific cytotoxic T-lymphocyte function. Immunology 124(4):553-61. [PubMed: 18298551]  [MGI Ref ID J:142777]

Gutcher I; Urich E; Wolter K; Prinz M; Becher B. 2006. Interleukin 18-independent engagement of interleukin 18 receptor-alpha is required for autoimmune inflammation. Nat Immunol 7(9):946-53. [PubMed: 16906165]  [MGI Ref ID J:112650]

Halder RC; Aguilera C; Maricic I; Kumar V. 2007. Type II NKT cell-mediated anergy induction in type I NKT cells prevents inflammatory liver disease. J Clin Invest 117(8):2302-12. [PubMed: 17641782]  [MGI Ref ID J:123961]

Happel KI; Dubin PJ; Zheng M; Ghilardi N; Lockhart C; Quinton LJ; Odden AR; Shellito JE; Bagby GJ; Nelson S; Kolls JK. 2005. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med 202(6):761-9. [PubMed: 16157683]  [MGI Ref ID J:107457]

Harrington LE; Hatton RD; Mangan PR; Turner H; Murphy TL; Murphy KM; Weaver CT. 2005. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6(11):1123-32. [PubMed: 16200070]  [MGI Ref ID J:112601]

Hart G; Flaishon L; Shachar I. 2007. IL-12 and IL-18 down-regulate B cell migration in an Ly49D-dependent manner. Eur J Immunol 37(7):1996-2007. [PubMed: 17557376]  [MGI Ref ID J:123474]

Hazlett LD; Li Q; Liu J; McClellan S; Du W; Barrett RP. 2007. NKT cells are critical to initiate an inflammatory response after Pseudomonas aeruginosa ocular infection in susceptible mice. J Immunol 179(2):1138-46. [PubMed: 17617607]  [MGI Ref ID J:149394]

Hazlett LD; Rudner XL; McClellan SA; Barrett RP; Lighvani S. 2002. Role of IL-12 and IFN-gamma in Pseudomonas aeruginosa corneal infection. Invest Ophthalmol Vis Sci 43(2):419-24. [PubMed: 11818386]  [MGI Ref ID J:74264]

Heidegger S; Kirchner SK; Stephan N; Bohn B; Suhartha N; Hotz C; Anz D; Sandholzer N; Stecher B; Russmann H; Endres S; Bourquin C. 2013. TLR activation excludes circulating naive CD8+ T cells from gut-associated lymphoid organs in mice. J Immunol 190(10):5313-20. [PubMed: 23589622]  [MGI Ref ID J:202547]

Helmby H. 2009. Gastrointestinal nematode infection exacerbates malaria-induced liver pathology. J Immunol 182(9):5663-71. [PubMed: 19380813]  [MGI Ref ID J:147710]

Helmby H; Grencis RK. 2002. IL-18 regulates intestinal mastocytosis and Th2 cytokine production independently of IFN-gamma during Trichinella spiralis infection. J Immunol 169(5):2553-60. [PubMed: 12193725]  [MGI Ref ID J:120688]

Henry CJ; Grayson JM; Brzoza-Lewis KL; Mitchell LM; Westcott MM; Cook AS; Hiltbold EM. 2010. The roles of IL-12 and IL-23 in CD8+ T cell-mediated immunity against Listeria monocytogenes: Insights from a DC vaccination model. Cell Immunol 264(1):23-31. [PubMed: 20483409]  [MGI Ref ID J:162123]

Henry CJ; Ornelles DA; Mitchell LM; Brzoza-Lewis KL; Hiltbold EM. 2008. IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17. J Immunol 181(12):8576-84. [PubMed: 19050277]  [MGI Ref ID J:142058]

Hino A; Kweon MN; Fujihashi K; McGhee JR; Kiyono H. 2004. Pathological role of large intestinal IL-12p40 for the induction of Th2-type allergic diarrhea. Am J Pathol 164(4):1327-35. [PubMed: 15039220]  [MGI Ref ID J:89151]

Hoffmann KF; Cheever AW; Wynn TA. 2000. IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis. J Immunol 164(12):6406-16. [PubMed: 10843696]  [MGI Ref ID J:124519]

Hoffmann KF; James SL; Cheever AW; Wynn TA. 1999. Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni. J Immunol 163(2):927-38. [PubMed: 10395689]  [MGI Ref ID J:56157]

Holscher C; Atkinson RA; Arendse B; Brown N; Myburgh E; Alber G; Brombacher F. 2001. A protective and agonistic function of IL-12p40 in mycobacterial infection. J Immunol 167(12):6957-66. [PubMed: 11739515]  [MGI Ref ID J:73093]

Hosiawa KA; Wang H; DeVries ME; Garcia B; Liu W; Zhou D; Akram A; Jiang J; Sun H; Cameron MJ; Zhong R; Kelvin DJ. 2005. CD80/CD86 costimulation regulates acute vascular rejection. J Immunol 175(9):6197-204. [PubMed: 16237117]  [MGI Ref ID J:119363]

Houpt ER; Glembocki DJ; Obrig TG; Moskaluk CA; Lockhart LA; Wright RL; Seaner RM; Keepers TR; Wilkins TD; Petri WA Jr. 2002. The mouse model of amebic colitis reveals mouse strain susceptibility to infection and exacerbation of disease by CD4+ T cells. J Immunol 169(8):4496-503. [PubMed: 12370386]  [MGI Ref ID J:120012]

Huaux F; Arras M; Tomasi D; Barbarin V; Delos M; Coutelier JP; Vink A; Phan SH; Renauld JC; Lison D. 2002. A profibrotic function of IL-12p40 in experimental pulmonary fibrosis. J Immunol 169(5):2653-61. [PubMed: 12193738]  [MGI Ref ID J:120205]

Hunter CA; Yu D; Gee M; Ngo CV; Sevignani C; Goldschmidt M; Golovkina TV; Evans S; Lee WF; Thomas-Tikhonenko A. 2001. Cutting edge: systemic inhibition of angiogenesis underlies resistance to tumors during acute toxoplasmosis. J Immunol 166(10):5878-81. [PubMed: 11342601]  [MGI Ref ID J:124573]

Ishii KJ; Ito S; Tamura T; Hemmi H; Conover J; Ozato K; Akira S; Klinman DM. 2005. CpG-activated Thy1.2+ dendritic cells protect against lethal Listeria monocytogenes infection. Eur J Immunol 35(8):2397-405. [PubMed: 16047338]  [MGI Ref ID J:100431]

Jankovic D; Kullberg MC; Hieny S; Caspar P; Collazo CM; Sher A. 2002. In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting. Immunity 16(3):429-39. [PubMed: 11911827]  [MGI Ref ID J:113516]

Jones TG; Hallgren J; Humbles A; Burwell T; Finkelman FD; Alcaide P; Austen KF; Gurish MF. 2009. Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells. J Immunol 183(8):5251-60. [PubMed: 19783672]  [MGI Ref ID J:153832]

Jouanguy E; Doffinger R; Dupuis S; Pallier A; Altare F; Casanova JL. 1999. IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men. Curr Opin Immunol 11(3):346-51. [PubMed: 10375558]  [MGI Ref ID J:55697]

Kagami S; Rizzo HL; Kurtz SE; Miller LS; Blauvelt A. 2010. IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicans. J Immunol 185(9):5453-62. [PubMed: 20921529]  [MGI Ref ID J:165179]

Kang SJ; Liang HE; Reizis B; Locksley RM. 2008. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity 29(5):819-33. [PubMed: 19006696]  [MGI Ref ID J:142395]

Karachunski PI; Ostlie NS; Monfardini C; Conti-Fine BM. 2000. Absence of IFN-gamma or IL-12 has different effects on experimental myasthenia gravis in C57BL/6 mice. J Immunol 164(10):5236-44. [PubMed: 10799884]  [MGI Ref ID J:62120]

Kawa K; Tsutsui H; Uchiyama R; Kato J; Matsui K; Iwakura Y; Matsumoto T; Nakanishi K. 2010. IFN-{gamma} is a master regulator of endotoxin shock syndrome in mice primed with heat-killed Propionibacterium acnes. Int Immunol 22(3):157-66. [PubMed: 20130231]  [MGI Ref ID J:157756]

Kawakami K; Kinjo Y; Uezu K; Miyagi K; Kinjo T; Yara S; Koguchi Y; Miyazato A; Shibuya K; Iwakura Y; Takeda K; Akira S; Saito A. 2004. Interferon-gamma production and host protective response against Mycobacterium tuberculosis in mice lacking both IL-12p40 and IL-18. Microbes Infect 6(4):339-49. [PubMed: 15050961]  [MGI Ref ID J:105389]

Kawakami K; Kinjo Y; Yara S; Uezu K; Koguchi Y; Tohyama M; Azuma M; Takeda K; Akira S; Saito A. 2001. Enhanced Gamma Interferon Production through Activation of Valpha14(+) Natural Killer T Cells by alpha-Galactosylceramide in Interleukin-18-Deficient Mice with Systemic Cryptococcosis. Infect Immun 69(11):6643-50. [PubMed: 11598033]  [MGI Ref ID J:72191]

Kawakami K; Koguchi Y; Qureshi MH; Miyazato A; Yara S; Kinjo Y; Iwakura Y; Takeda K; Akira S; Kurimoto M; Saito A. 2000. IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells. J Immunol 165(2):941-7. [PubMed: 10878369]  [MGI Ref ID J:120529]

Kawata K; Tsuda M; Yang GX; Zhang W; Tanaka H; Tsuneyama K; Leung P; He XS; Knechtle S; Ansari AA; Coppel RL; Gershwin ME. 2013. Identification of potential cytokine pathways for therapeutic intervention in murine primary biliary cirrhosis. PLoS One 8(9):e74225. [PubMed: 24040208]  [MGI Ref ID J:206046]

Keogh B; Atkins GJ; Mills KH; Sheahan BJ. 2002. Avirulent Semliki Forest virus replication and pathology in the central nervous system is enhanced in IL-12-defective and reduced in IL-4-defective mice: a role for Th1 cells in the protective immunity. J Neuroimmunol 125(1-2):15-22. [PubMed: 11960636]  [MGI Ref ID J:102960]

Khader SA; Bell GK; Pearl JE; Fountain JJ; Rangel-Moreno J; Cilley GE; Shen F; Eaton SM; Gaffen SL; Swain SL; Locksley RM; Haynes L; Randall TD; Cooper AM. 2007. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol 8(4):369-77. [PubMed: 17351619]  [MGI Ref ID J:120806]

Khader SA; Partida-Sanchez S; Bell G; Jelley-Gibbs DM; Swain S; Pearl JE; Ghilardi N; Desauvage FJ; Lund FE; Cooper AM. 2006. Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection. J Exp Med 203(7):1805-15. [PubMed: 16818672]  [MGI Ref ID J:124401]

Khader SA; Pearl JE; Sakamoto K; Gilmartin L; Bell GK; Jelley-Gibbs DM; Ghilardi N; deSauvage F; Cooper AM. 2005. IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available. J Immunol 175(2):788-95. [PubMed: 16002675]  [MGI Ref ID J:100721]

Khan IA; Matsuura T; Kasper LH. 1998. Inducible nitric oxide synthase is not required for long-term vaccine-based immunity against Toxoplasma gondii. J Immunol 161(6):2994-3000. [PubMed: 9743363]  [MGI Ref ID J:118438]

Kikawada E; Lenda DM; Kelley VR. 2003. IL-12 deficiency in MRL-Fas(lpr) mice delays nephritis and intrarenal IFN-gamma expression, and diminishes systemic pathology. J Immunol 170(7):3915-25. [PubMed: 12646661]  [MGI Ref ID J:106635]

Kim S; Lalani S; Parekh VV; Vincent TL; Wu L; Van Kaer L. 2008. Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice. J Clin Invest 118(6):2301-15. [PubMed: 18451996]  [MGI Ref ID J:137699]

Kinjo Y; Kawakami K; Uezu K; Yara S; Miyagi K; Koguchi Y; Hoshino T; Okamoto M; Kawase Y; Yokota K; Yoshino K; Takeda K; Akira S; Saito A. 2002. Contribution of IL-18 to Th1 response and host defense against infection by Mycobacterium tuberculosis: a comparative study with IL-12p40. J Immunol 169(1):323-9. [PubMed: 12077261]  [MGI Ref ID J:123789]

Kitching AR; Tipping PG; Kurimoto M; Holdsworth SR. 2000. IL-18 has IL-12-independent effects in delayed-type hypersensitivity: studies in cell-mediated crescentic glomerulonephritis. J Immunol 165(8):4649-57. [PubMed: 11035108]  [MGI Ref ID J:118441]

Kitching AR; Turner AL; Semple T; Li M; Edgtton KL; Wilson GR; Timoshanko JR; Hudson BG; Holdsworth SR. 2004. Experimental autoimmune anti-glomerular basement membrane glomerulonephritis: a protective role for IFN-gamma. J Am Soc Nephrol 15(7):1764-74. [PubMed: 15213264]  [MGI Ref ID J:132564]

Kitching AR; Turner AL; Wilson GR; Semple T; Odobasic D; Timoshanko JR; O'Sullivan KM; Tipping PG; Takeda K; Akira S; Holdsworth SR. 2005. IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment. J Am Soc Nephrol 16(7):2023-33. [PubMed: 15888563]  [MGI Ref ID J:114369]

Kleinschek MA; Muller U; Brodie SJ; Stenzel W; Kohler G; Blumenschein WM; Straubinger RK; McClanahan T; Kastelein RA; Alber G. 2006. IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12. J Immunol 176(2):1098-106. [PubMed: 16393998]  [MGI Ref ID J:126443]

Ko J; Gendron-Fitzpatrick A; Splitter GA. 2002. Susceptibility of IFN regulatory factor-1 and IFN consensus sequence binding protein-deficient mice to brucellosis. J Immunol 168(5):2433-40. [PubMed: 11859135]  [MGI Ref ID J:74725]

Kobayashi M; Kweon MN; Kuwata H; Schreiber RD; Kiyono H; Takeda K; Akira S. 2003. Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J Clin Invest 111(9):1297-308. [PubMed: 12727921]  [MGI Ref ID J:83280]

Kohyama S; Ohno S; Isoda A; Moriya O; Belladonna ML; Hayashi H; Iwakura Y; Yoshimoto T; Akatsuka T; Matsui M. 2007. IL-23 enhances host defense against vaccinia virus infection via a mechanism partly involving IL-17. J Immunol 179(6):3917-25. [PubMed: 17785829]  [MGI Ref ID J:152039]

Kontoyiannis D; Boulougouris G; Manoloukos M; Armaka M; Apostolaki M; Pizarro T; Kotlyarov A; Forster I; Flavell R; Gaestel M; Tsichlis P; Cominelli F; Kollias G. 2002. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med 196(12):1563-74. [PubMed: 12486099]  [MGI Ref ID J:108572]

Koschella M; Voehringer D; Pircher H. 2004. CD40 ligation in vivo induces bystander proliferation of memory phenotype CD8 T cells. J Immunol 172(8):4804-11. [PubMed: 15067057]  [MGI Ref ID J:89113]

Kreymborg K; Etzensperger R; Dumoutier L; Haak S; Rebollo A; Buch T; Heppner FL; Renauld JC; Becher B. 2007. IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J Immunol 179(12):8098-104. [PubMed: 18056351]  [MGI Ref ID J:155038]

Langowski JL; Zhang X; Wu L; Mattson JD; Chen T; Smith K; Basham B; McClanahan T; Kastelein RA; Oft M. 2006. IL-23 promotes tumour incidence and growth. Nature 442(7101):461-5. [PubMed: 16688182]  [MGI Ref ID J:111568]

Langrish CL; Chen Y; Blumenschein WM; Mattson J; Basham B; Sedgwick JD; McClanahan T; Kastelein RA; Cua DJ. 2005. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 201(2):233-40. [PubMed: 15657292]  [MGI Ref ID J:95542]

Lauw FN; Florquin S; Speelman P; van Deventer SJ; van der Poll T. 2001. Role of endogenous interleukin-12 in immune response to staphylococcal enterotoxin B in mice. Infect Immun 69(9):5949-52. [PubMed: 11500480]  [MGI Ref ID J:71227]

Lee YK; Turner H; Maynard CL; Oliver JR; Chen D; Elson CO; Weaver CT. 2009. Late developmental plasticity in the T helper 17 lineage. Immunity 30(1):92-107. [PubMed: 19119024]  [MGI Ref ID J:143729]

Lewkowich IP; Rempel JD; HayGlass KT. 2005. Prevention of allergen-specific, Th2-biased immune responses in vivo: role of increased IL-12 and IL-18 responsiveness. J Immunol 175(8):4956-62. [PubMed: 16210597]  [MGI Ref ID J:119100]

Li CK; Pender SL; Pickard KM; Chance V; Holloway JA; Huett A; Goncalves NS; Mudgett JS; Dougan G; Frankel G; MacDonald TT. 2004. Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice. J Immunol 173(8):5171-9. [PubMed: 15470062]  [MGI Ref ID J:93706]

Li L; Hsu HC; Stockard CR; Yang P; Zhou J; Wu Q; Grizzle WE; Mountz JD. 2004. IL-12 inhibits thymic involution by enhancing IL-7- and IL-2-induced thymocyte proliferation. J Immunol 172(5):2909-16. [PubMed: 14978093]  [MGI Ref ID J:88230]

Lieberman LA; Cardillo F; Owyang AM; Rennick DM; Cua DJ; Kastelein RA; Hunter CA. 2004. IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12. J Immunol 173(3):1887-93. [PubMed: 15265921]  [MGI Ref ID J:92028]

Lin AC; Dissanayake D; Dhanji S; Elford AR; Ohashi PS. 2011. Different toll-like receptor stimuli have a profound impact on cytokines required to break tolerance and induce autoimmunity. PLoS One 6(9):e23940. [PubMed: 21931625]  [MGI Ref ID J:177886]

Lin Y; Ritchea S; Logar A; Slight S; Messmer M; Rangel-Moreno J; Guglani L; Alcorn JF; Strawbridge H; Park SM; Onishi R; Nyugen N; Walter MJ; Pociask D; Randall TD; Gaffen SL; Iwakura Y; Kolls JK; Khader SA. 2009. Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis. Immunity 31(5):799-810. [PubMed: 19853481]  [MGI Ref ID J:155349]

Lindsay RW; Darrah PA; Quinn KM; Wille-Reece U; Mattei LM; Iwasaki A; Kasturi SP; Pulendran B; Gall JG; Spies AG; Seder RA. 2010. CD8+ T cell responses following replication-defective adenovirus serotype 5 immunization are dependent on CD11c+ dendritic cells but show redundancy in their requirement of TLR and nucleotide-binding oligomerization domain-like receptor signaling. J Immunol 185(3):1513-21. [PubMed: 20610651]  [MGI Ref ID J:162242]

Liu J; Xiang Z; Ma X. 2004. Role of IFN regulatory factor-1 and IL-12 in immunological resistance to pathogenesis of N-methyl-N-nitrosourea-induced T lymphoma. J Immunol 173(2):1184-93. [PubMed: 15240709]  [MGI Ref ID J:91927]

Liva SM; Voskuhl RR. 2001. Testosterone acts directly on CD4+ T lymphocytes to increase IL-10 production. J Immunol 167(4):2060-7. [PubMed: 11489988]  [MGI Ref ID J:120413]

Lucas M; Schachterle W; Oberle K; Aichele P; Diefenbach A. 2007. Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity 26(4):503-17. [PubMed: 17398124]  [MGI Ref ID J:123584]

Luger D; Silver PB; Tang J; Cua D; Chen Z; Iwakura Y; Bowman EP; Sgambellone NM; Chan CC; Caspi RR. 2008. Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med 205(4):799-810. [PubMed: 18391061]  [MGI Ref ID J:133969]

MacDonald AS; Pearce EJ. 2002. Cutting edge: polarized Th cell response induction by transferred antigen-pulsed dendritic cells is dependent on IL-4 or IL-12 production by recipient cells. J Immunol 168(7):3127-30. [PubMed: 11907061]  [MGI Ref ID J:126393]

Madala SK; Pesce JT; Ramalingam TR; Wilson MS; Minnicozzi S; Cheever AW; Thompson RW; Mentink-Kane MM; Wynn TA. 2010. Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis. J Immunol 184(7):3955-63. [PubMed: 20181883]  [MGI Ref ID J:160097]

Maeda A; Schneider SW; Kojima M; Beissert S; Schwarz T; Schwarz A. 2006. Enhanced photocarcinogenesis in interleukin-12-deficient mice. Cancer Res 66(6):2962-9. [PubMed: 16540644]  [MGI Ref ID J:107060]

Mallevaey T; Zanetta JP; Faveeuw C; Fontaine J; Maes E; Platt F; Capron M; de-Moraes ML; Trottein F. 2006. Activation of invariant NKT cells by the helminth parasite schistosoma mansoni. J Immunol 176(4):2476-85. [PubMed: 16456008]  [MGI Ref ID J:129188]

Marques VP; Goncalves GM; Feitoza CQ; Cenedeze MA; Fernandes Bertocchi AP; Damiao MJ; Pinheiro HS; Antunes Teixeira VP; dos Reis MA; Pacheco-Silva A; Saraiva Camara NO. 2006. Influence of TH1/TH2 switched immune response on renal ischemia-reperfusion injury. Nephron Exp Nephrol 104(1):e48-56. [PubMed: 16741373]  [MGI Ref ID J:127477]

Marshall HD; Prince AL; Berg LJ; Welsh RM. 2010. IFN-alphabeta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions. J Immunol 185(3):1419-28. [PubMed: 20592282]  [MGI Ref ID J:162457]

Martin DL; King CL; Pearlman E; Strine E; Heinzel FP. 2000. IFN-gamma is necessary but not sufficient for anti-CD40 antibody-mediated inhibition of the Th2 response to Schistosoma mansoni eggs. J Immunol 164(2):779-85. [PubMed: 10623823]  [MGI Ref ID J:59303]

Masocha W; Robertson B; Rottenberg ME; Mhlanga J; Sorokin L; Kristensson K. 2004. Cerebral vessel laminins and IFN-gamma define Trypanosoma brucei brucei penetration of the blood-brain barrier. J Clin Invest 114(5):689-94. [PubMed: 15343387]  [MGI Ref ID J:92595]

Mattarollo SR; West AC; Steegh K; Duret H; Paget C; Martin B; Matthews GM; Shortt J; Chesi M; Bergsagel PL; Bots M; Zuber J; Lowe SW; Johnstone RW; Smyth MJ. 2012. NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma. Blood 120(15):3019-29. [PubMed: 22932803]  [MGI Ref ID J:192928]

Mattner F; Magram J; Ferrante J; Launois P; Di Padova K; Behin R; Gately MK; Louis JA; Alber G. 1996. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur J Immunol 26(7):1553-9. [PubMed: 8766560]  [MGI Ref ID J:34164]

Maxwell JR; Yadav R; Rossi RJ; Ruby CE; Weinberg AD; Aguila HL; Vella AT. 2006. IL-18 bridges innate and adaptive immunity through IFN-gamma and the CD134 pathway. J Immunol 177(1):234-45. [PubMed: 16785519]  [MGI Ref ID J:134442]

McAleer JP; Liu B; Li Z; Ngoi SM; Dai J; Oft M; Vella AT. 2010. Potent intestinal Th17 priming through peripheral lipopolysaccharide-based immunization. J Leukoc Biol 88(1):21-31. [PubMed: 20130220]  [MGI Ref ID J:162449]

McAleer JP; Saris CJ; Vella AT. 2011. The WSX-1 pathway restrains intestinal T-cell immunity. Int Immunol 23(2):129-37. [PubMed: 21233255]  [MGI Ref ID J:168576]

McBride S; Hoebe K; Georgel P; Janssen E. 2006. Cell-associated double-stranded RNA enhances antitumor activity through the production of type I IFN. J Immunol 177(9):6122-8. [PubMed: 17056539]  [MGI Ref ID J:140522]

McIntyre KW; Shuster DJ; Gillooly KM; Warrier RR; Connaughton SE ; Hall LB ; Arp LH ; Gately MK ; Magram J. 1996. Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice. Eur J Immunol 26(12):2933-8. [PubMed: 8977288]  [MGI Ref ID J:37075]

Meeran SM; Akhtar S; Katiyar SK. 2009. Inhibition of UVB-induced skin tumor development by drinking green tea polyphenols is mediated through DNA repair and subsequent inhibition of inflammation. J Invest Dermatol 129(5):1258-70. [PubMed: 19020550]  [MGI Ref ID J:150981]

Mencacci A; Cenci E; Del Sero G; Fe d'Ostiani C; Mosci P; Trinchieri G; Adorini L; Romani L. 1998. IL-10 is required for development of protective Th1 responses in IL-12-deficient mice upon Candida albicans infection. J Immunol 161(11):6228-37. [PubMed: 9834110]  [MGI Ref ID J:115101]

Michels C; Goyal P; Nieuwenhuizen N; Brombacher F. 2006. Infection with Syphacia obvelata (pinworm) induces protective Th2 immune responses and influences ovalbumin-induced allergic reactions. Infect Immun 74(10):5926-32. [PubMed: 16988272]  [MGI Ref ID J:112864]

Minami K; Yanagawa Y; Iwabuchi K; Shinohara N; Harabayashi T; Nonomura K; Onoe K. 2005. Negative feedback regulation of T helper type 1 (Th1)/Th2 cytokine balance via dendritic cell and natural killer T cell interactions. Blood 106(5):1685-93. [PubMed: 15878981]  [MGI Ref ID J:118514]

Moreno SE; Alves-Filho JC; Alfaya TM; da Silva JS; Ferreira SH; Liew FY. 2006. IL-12, but not IL-18, is critical to neutrophil activation and resistance to polymicrobial sepsis induced by cecal ligation and puncture. J Immunol 177(5):3218-24. [PubMed: 16920961]  [MGI Ref ID J:139542]

Mota BE; Gallardo-Romero N; Trindade G; Keckler MS; Karem K; Carroll D; Campos MA; Vieira LQ; da Fonseca FG; Ferreira PC; Bonjardim CA; Damon IK; Kroon EG. 2011. Adverse Events Post Smallpox-Vaccination: Insights from Tail Scarification Infection in Mice with Vaccinia virus. PLoS One 6(4):e18924. [PubMed: 21526210]  [MGI Ref ID J:172270]

Mott KR; Gate D; Zandian M; Allen SJ; Rajasagi NK; van Rooijen N; Chen S; Arditi M; Rouse BT; Flavell RA; Town T; Ghiasi H. 2011. Macrophage IL-12p70 Signaling Prevents HSV-1-Induced CNS Autoimmunity Triggered by Autoaggressive CD4+ Tregs. Invest Ophthalmol Vis Sci 52(5):2321-33. [PubMed: 21220560]  [MGI Ref ID J:171538]

Mowat AM; Steel M; Leishman AJ; Garside P. 1999. Normal induction of oral tolerance in the absence of a functional IL-12-dependent IFN-gamma signaling pathway. J Immunol 163(9):4728-36. [PubMed: 10528171]  [MGI Ref ID J:119049]

Mukasa R; Balasubramani A; Lee YK; Whitley SK; Weaver BT; Shibata Y; Crawford GE; Hatton RD; Weaver CT. 2010. Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. Immunity 32(5):616-27. [PubMed: 20471290]  [MGI Ref ID J:160694]

Mullarky IK; Szaba FM; Berggren KN; Kummer LW; Wilhelm LB; Parent MA; Johnson LL; Smiley ST. 2006. Tumor necrosis factor alpha and gamma interferon, but not hemorrhage or pathogen burden, dictate levels of protective fibrin deposition during infection. Infect Immun 74(2):1181-8. [PubMed: 16428767]  [MGI Ref ID J:104988]

Murray HW; Tsai CW; Liu J; Ma X. 2006. Responses to Leishmania donovani in mice deficient in interleukin-12 (IL-12), IL-12/IL-23, or IL-18. Infect Immun 74(7):4370-4. [PubMed: 16790814]  [MGI Ref ID J:110039]

Nagarajan NA; Kronenberg M. 2007. Invariant NKT cells amplify the innate immune response to lipopolysaccharide. J Immunol 178(5):2706-13. [PubMed: 17312112]  [MGI Ref ID J:144118]

Nakano N; Nishiyama C; Kanada S; Niwa Y; Shimokawa N; Ushio H; Nishiyama M; Okumura K; Ogawa H. 2007. Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections. Blood 109(11):4846-55. [PubMed: 17289816]  [MGI Ref ID J:145437]

Nguyen KB; Salazar-Mather TP; Dalod MY; Van Deusen JB; Wei XQ; Liew FY; Caligiuri MA; Durbin JE; Biron CA. 2002. Coordinated and distinct roles for IFN-alphabeta, IL-12, and IL-15 regulation of NK cell responses to viral infection. J Immunol 169(8):4279-87. [PubMed: 12370359]  [MGI Ref ID J:79552]

Niess JH; Leithauser F; Adler G; Reimann J. 2008. Commensal gut flora drives the expansion of proinflammatory CD4 T cells in the colonic lamina propria under normal and inflammatory conditions. J Immunol 180(1):559-68. [PubMed: 18097058]  [MGI Ref ID J:130910]

Nunez NG; Andreani V; Crespo MI; Nocera DA; Breser ML; Moron G; Dejager L; Libert C; Rivero V; Maccioni M. 2012. IFNbeta produced by TLR4-activated tumor cells is involved in improving the antitumoral immune response. Cancer Res 72(3):592-603. [PubMed: 22139376]  [MGI Ref ID J:181135]

Orgun NN; Mathis MA; Wilson CB; Way SS. 2008. Deviation from a Strong Th1-Dominated to a Modest Th17-Dominated CD4 T Cell Response in the Absence of IL-12p40 and Type I IFNs Sustains Protective CD8 T Cells. J Immunol 180(6):4109-15. [PubMed: 18322221]  [MGI Ref ID J:132929]

Osterloh A; Veit A; Gessner A; Fleischer B; Breloer M. 2008. Hsp60-mediated T cell stimulation is independent of TLR4 and IL-12. Int Immunol 20(3):433-43. [PubMed: 18256040]  [MGI Ref ID J:131964]

Owaki T; Asakawa M; Morishima N; Hata K; Fukai F; Matsui M; Mizuguchi J; Yoshimoto T. 2005. A role for IL-27 in early regulation of Th1 differentiation. J Immunol 175(4):2191-200. [PubMed: 16081786]  [MGI Ref ID J:107503]

Oxenius A; Karrer U; Zinkernagel RM; Hengartner H. 1999. IL-12 is not required for induction of type 1 cytokine responses in viral infections. J Immunol 162(2):965-73. [PubMed: 9916721]  [MGI Ref ID J:124672]

Paget C; Mallevaey T; Speak AO; Torres D; Fontaine J; Sheehan KC; Capron M; Ryffel B; Faveeuw C; Leite de Moraes M; Platt F; Trottein F. 2007. Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids. Immunity 27(4):597-609. [PubMed: 17950005]  [MGI Ref ID J:126128]

Park AY; Hondowicz BD; Scott P. 2000. IL-12 is required to maintain a Th1 response during Leishmania major infection. J Immunol 165(2):896-902. [PubMed: 10878364]  [MGI Ref ID J:120526]

Pearce EL; Shen H. 2007. Generation of CD8 T cell memory is regulated by IL-12. J Immunol 179(4):2074-81. [PubMed: 17675465]  [MGI Ref ID J:151232]

Peine M; Rausch S; Helmstetter C; Frohlich A; Hegazy AN; Kuhl AA; Grevelding CG; Hofer T; Hartmann S; Lohning M. 2013. Stable T-bet(+)GATA-3(+) Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation. PLoS Biol 11(8):e1001633. [PubMed: 23976880]  [MGI Ref ID J:201585]

Persky ME; Murphy KM; Farrar JD. 2005. IL-12, but not IFN-alpha, promotes STAT4 activation and Th1 development in murine CD4+ T cells expressing a chimeric murine/human Stat2 gene. J Immunol 174(1):294-301. [PubMed: 15611252]  [MGI Ref ID J:95855]

Pesce J; Kaviratne M; Ramalingam TR; Thompson RW; Urban JF Jr; Cheever AW; Young DA; Collins M; Grusby MJ; Wynn TA. 2006. The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J Clin Invest 116(7):2044-55. [PubMed: 16778988]  [MGI Ref ID J:111712]

Petry F; Jakobi V; Wagner S; Tessema TS; Thiel S; Loos M. 2008. Binding and activation of human and mouse complement by Cryptosporidium parvum (Apicomplexa) and susceptibility of C1q- and MBL-deficient mice to infection. Mol Immunol 45(12):3392-400. [PubMed: 18501966]  [MGI Ref ID J:137680]

Piccotti JR; Li K; Chan SY; Ferrante J; Magram J; Eichwald EJ; Bishop DK. 1998. Alloantigen-reactive Th1 development in IL-12-deficient mice. J Immunol 160(3):1132-8. [PubMed: 9570526]  [MGI Ref ID J:90552]

Pien GC; Nguyen KB; Malmgaard L; Satoskar AR; Biron CA. 2002. A unique mechanism for innate cytokine promotion of T cell responses to viral infections. J Immunol 169(10):5827-37. [PubMed: 12421964]  [MGI Ref ID J:80075]

Price JD; Simpfendorfer KR; Mantena RR; Holden J; Heath WR; van Rooijen N; Strugnell RA; Wijburg OL. 2007. Gamma interferon-independent effects of interleukin-12 on immunity to Salmonella enterica serovar Typhimurium. Infect Immun 75(12):5753-62. [PubMed: 17875635]  [MGI Ref ID J:127653]

Ramirez-Pineda JR; Frohlich A; Berberich C; Moll H. 2004. Dendritic cells (DC) activated by CpG DNA ex vivo are potent inducers of host resistance to an intracellular pathogen that is independent of IL-12 derived from the immunizing DC. J Immunol 172(10):6281-9. [PubMed: 15128817]  [MGI Ref ID J:89850]

Reading PC; Whitney PG; Barr DP; Wojtasiak M; Mintern JD; Waithman J; Brooks AG. 2007. IL-18, but not IL-12, regulates NK cell activity following intranasal herpes simplex virus type 1 infection. J Immunol 179(5):3214-21. [PubMed: 17709537]  [MGI Ref ID J:151826]

Reinhardt RL; Hong S; Kang SJ; Wang ZE; Locksley RM. 2006. Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation. J Immunol 177(3):1618-27. [PubMed: 16849470]  [MGI Ref ID J:112745]

Rempel JD; Lewkowich IP; HayGlass KT. 2000. Endogenous IL-12 synthesis is not required to prevent hyperexpression of type 2 cytokine and antibody responses. Eur J Immunol 30(2):347-55. [PubMed: 10671189]  [MGI Ref ID J:115321]

Rigato PO; de Alencar BC; de Vasconcelos JR; Dominguez MR; Araujo AF; Machado AV; Gazzinelli RT; Bruna-Romero O; Rodrigues MM. 2011. Heterologous Plasmid DNA Prime-Recombinant Human Adenovirus 5 Boost Vaccination Generates a Stable Pool of Protective Long-Lived CD8+ T Effector Memory Cells Specific for a Human Parasite, Trypanosoma cruzi. Infect Immun 79(5):2120-30. [PubMed: 21357719]  [MGI Ref ID J:171948]

Robinson RT; Khader SA; Locksley RM; Lien E; Smiley ST; Cooper AM. 2008. Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration. J Immunol 181(8):5560-7. [PubMed: 18832714]  [MGI Ref ID J:140760]

Robinson RT; Khader SA; Martino CA; Fountain JJ; Teixeira-Coelho M; Pearl JE; Smiley ST; Winslow GM; Woodland DL; Walter MJ; Conejo-Garcia JR; Gubler U; Cooper AM. 2010. Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration. J Exp Med 207(3):591-605. [PubMed: 20212068]  [MGI Ref ID J:158809]

Rodeghero R; Cao Y; Olalekan SA; Iwakua Y; Glant TT; Finnegan A. 2013. Location of CD4+ T cell priming regulates the differentiation of Th1 and Th17 cells and their contribution to arthritis. J Immunol 190(11):5423-35. [PubMed: 23630349]  [MGI Ref ID J:204778]

Rosas LE; Keiser T; Pyles R; Durbin J; Satoskar AR. 2003. Development of protective immunity against cutaneous leishmaniasis is dependent on STAT1-mediated IFN signaling pathway. Eur J Immunol 33(7):1799-805. [PubMed: 12811839]  [MGI Ref ID J:84419]

Rosborough BR; Raich-Regue D; Matta BM; Lee K; Gan B; DePinho RA; Hackstein H; Boothby M; Turnquist HR; Thomson AW. 2013. Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction. Blood 121(18):3619-30. [PubMed: 23444404]  [MGI Ref ID J:197572]

Rothfuchs AG; Gigliotti D; Palmblad K; Andersson U; Wigzell H; Rottenberg ME. 2001. IFN-alphabeta-dependent, IFN-gamma secretion by bone marrow-derived macrophages controls an intracellular bacterial infection. J Immunol 167(11):6453-61. [PubMed: 11714812]  [MGI Ref ID J:72825]

Rottenberg ME; Gigliotti Rothfuchs A; Gigliotti D; Ceausu M; Une C; Levitsky V; Wigzell H. 2000. Regulation and role of IFN-gamma in the innate resistance to infection with Chlamydia pneumoniae. J Immunol 164(9):4812-8. [PubMed: 10779789]  [MGI Ref ID J:124531]

Rowe JH; Ertelt JM; Way SS. 2012. Innate IFN-gamma is essential for programmed death ligand-1-mediated T cell stimulation following Listeria monocytogenes infection. J Immunol 189(2):876-84. [PubMed: 22711893]  [MGI Ref ID J:189796]

Ruan S; McKinley L; Zheng M; Rudner X; D'Souza A; Kolls JK; Shellito JE. 2008. Interleukin-12 and host defense against murine Pneumocystis pneumonia. Infect Immun 76(5):2130-7. [PubMed: 18332204]  [MGI Ref ID J:134470]

Rutitzky LI; Lopes da Rosa JR; Stadecker MJ. 2005. Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is dependent on IL-12p40 and correlates with high levels of IL-17. J Immunol 175(6):3920-6. [PubMed: 16148138]  [MGI Ref ID J:116693]

Sakamoto H; Zhao LH; Jain F; Kradin R. 2002. IL-12p40(-/-) mice treated with intratracheal bleomycin exhibit decreased pulmonary inflammation and increased fibrosis. Exp Mol Pathol 72(1):1-9. [PubMed: 11784117]  [MGI Ref ID J:105860]

Santos LL; Milenkovski GP; Hall PH; Leech M; Sharma L; Takeda K; Akira S; Kitching AR; Morand EF. 2006. IL-18 is redundant in T-cell responses and in joint inflammation in antigen-induced arthritis. Immunol Cell Biol 84(2):166-73. [PubMed: 16519734]  [MGI Ref ID J:105836]

Sato A; Iwasaki A. 2004. Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments. Proc Natl Acad Sci U S A 101(46):16274-9. [PubMed: 15534227]  [MGI Ref ID J:94732]

Satoskar AR; Rodig S; Telford SR 3rd; Satoskar AA; Ghosh SK; von Lichtenberg F; David JR. 2000. IL-12 gene-deficient C57BL/6 mice are susceptible to Leishmania donovani but have diminished hepatic immunopathology. Eur J Immunol 30(3):834-9. [PubMed: 10741399]  [MGI Ref ID J:60891]

Sawaki J; Tsutsui H; Hayashi N; Yasuda K; Akira S; Tanizawa T; Nakanishi K. 2007. Type 1 cytokine/chemokine production by mouse NK cells following activation of their TLR/MyD88-mediated pathways. Int Immunol 19(3):311-20. [PubMed: 17289654]  [MGI Ref ID J:118680]

Scharton-Kersten T; Contursi C; Masumi A; Sher A; Ozato K. 1997. Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. J Exp Med 186(9):1523-34. [PubMed: 9348310]  [MGI Ref ID J:111178]

Schijns VE; Haagmans BL; Wierda CM; Kruithof B; Heijnen IA; Alber G; Horzinek MC. 1998. Mice lacking IL-12 develop polarized Th1 cells during viral infection. J Immunol 160(8):3958-64. [PubMed: 9558103]  [MGI Ref ID J:46942]

Schleicher U; Liese J; Knippertz I; Kurzmann C; Hesse A; Heit A; Fischer JA; Weiss S; Kalinke U; Kunz S; Bogdan C. 2007. NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J Exp Med 204(4):893-906. [PubMed: 17389237]  [MGI Ref ID J:125611]

Schulz SM; Kohler G; Schutze N; Knauer J; Straubinger RK; Chackerian AA; Witte E; Wolk K; Sabat R; Iwakura Y; Holscher C; Muller U; Kastelein RA; Alber G. 2008. Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17. J Immunol 181(11):7891-901. [PubMed: 19017979]  [MGI Ref ID J:142381]

Seki E; Tsutsui H; Tsuji NM; Hayashi N; Adachi K; Nakano H; Futatsugi-Yumikura S; Takeuchi O; Hoshino K; Akira S; Fujimoto J; Nakanishi K. 2002. Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice. J Immunol 169(7):3863-8. [PubMed: 12244183]  [MGI Ref ID J:120385]

Shen H; Iwasaki A. 2006. A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide. J Clin Invest 116(8):2237-43. [PubMed: 16878177]  [MGI Ref ID J:113124]

Shi M; Ye Z; Umeshappa KS; Moyana T; Xiang J. 2007. Alpha tumor necrosis factor contributes to CD8(+) T cell survival in the transition phase. Biochem Biophys Res Commun 360(3):702-7. [PubMed: 17618911]  [MGI Ref ID J:123025]

Simmons CP; Goncalves NS; Ghaem-Maghami M; Bajaj-Elliott M; Clare S; Neves B; Frankel G; Dougan G; MacDonald TT. 2002. Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma. J Immunol 168(4):1804-12. [PubMed: 11823513]  [MGI Ref ID J:74480]

Simmons CP; Mastroeni P; Fowler R; Ghaem-maghami M; Lycke N; Pizza M; Rappuoli R; Dougan G. 1999. MHC class I-restricted cytotoxic lymphocyte responses induced by enterotoxin-based mucosal adjuvants. J Immunol 163(12):6502-10. [PubMed: 10586042]  [MGI Ref ID J:58977]

Skok J; Poudrier J; Gray D. 1999. Dendritic cell-derived IL-12 promotes B cell induction of Th2 differentiation: a feedback regulation of Th1 development. J Immunol 163(8):4284-91. [PubMed: 10510367]  [MGI Ref ID J:119232]

Skokos D; Nussenzweig MC. 2007. CD8- DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS. J Exp Med 204(7):1525-31. [PubMed: 17576775]  [MGI Ref ID J:125873]

Smeltz RB; Chen J; Shevach EM. 2005. Transforming growth factor-beta1 enhances the interferon-gamma-dependent, interleukin-12-independent pathway of T helper 1 cell differentiation. Immunology 114(4):484-92. [PubMed: 15804285]  [MGI Ref ID J:97437]

Smith E; Zarbock A; Stark MA; Burcin TL; Bruce AC; Foley P; Ley K. 2007. IL-23 is required for neutrophil homeostasis in normal and neutrophilic mice. J Immunol 179(12):8274-9. [PubMed: 18056371]  [MGI Ref ID J:155034]

Smyth MJ; Thia KY; Street SE; Cretney E; Trapani JA; Taniguchi M; Kawano T; Pelikan SB; Crowe NY; Godfrey DI. 2000. Differential tumor surveillance by natural killer (NK) and NKT cells. J Exp Med 191(4):661-8. [PubMed: 10684858]  [MGI Ref ID J:124663]

Soares H; Waechter H; Glaichenhaus N; Mougneau E; Yagita H; Mizenina O; Dudziak D; Nussenzweig MC; Steinman RM. 2007. A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo. J Exp Med 204(5):1095-106. [PubMed: 17438065]  [MGI Ref ID J:125741]

Somigliana E; Vigano P; Filardo P; Candiani M; Vignali M; Panina-Bordignon P. 2001. Use of knockout transgenic mice in the study of endometriosis: insights from mice lacking beta(2)-microglobulin and interleukin-12p40. Fertil Steril 75(1):203-6. [PubMed: 11163839]  [MGI Ref ID J:66996]

Sonderegger I; Rohn TA; Kurrer MO; Iezzi G; Zou Y; Kastelein RA; Bachmann MF; Kopf M. 2006. Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis. Eur J Immunol 36(11):2849-56. [PubMed: 17039570]  [MGI Ref ID J:116998]

Stager S; Maroof A; Zubairi S; Sanos SL; Kopf M; Kaye PM. 2006. Distinct roles for IL-6 and IL-12p40 in mediating protection against Leishmania donovani and the expansion of IL-10+ CD4+ T cells. Eur J Immunol 36(7):1764-71. [PubMed: 16791879]  [MGI Ref ID J:115789]

Stobie L; Gurunathan S; Prussin C; Sacks DL; Glaichenhaus N; Wu CY; Seder RA. 2000. The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge. Proc Natl Acad Sci U S A 97(15):8427-32. [PubMed: 10890924]  [MGI Ref ID J:63412]

Stokes KY; Clanton EC; Gehrig JL; Granger DN. 2003. Role of interleukin 12 in hypercholesterolemia-induced inflammation. Am J Physiol Heart Circ Physiol 285(6):H2623-9. [PubMed: 12907426]  [MGI Ref ID J:108153]

Street SE; Cretney E; Smyth MJ. 2001. Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis. Blood 97(1):192-7. [PubMed: 11133760]  [MGI Ref ID J:68550]

Street SE; Trapani JA; MacGregor D; Smyth MJ. 2002. Suppression of lymphoma and epithelial malignancies effected by interferon gamma. J Exp Med 196(1):129-34. [PubMed: 12093877]  [MGI Ref ID J:77491]

Su Z; Stevenson MM. 2002. IL-12 is required for antibody-mediated protective immunity against blood-stage Plasmodium chabaudi AS malaria infection in mice. J Immunol 168(3):1348-55. [PubMed: 11801675]  [MGI Ref ID J:127287]

Swain SD; Siemsen DW; Pullen RR; Han S. 2014. CD4+ T cells and IFN-gamma are required for the development of Pneumocystis-associated pulmonary hypertension. Am J Pathol 184(2):483-93. [PubMed: 24361497]  [MGI Ref ID J:206386]

Swann JB; Vesely MD; Silva A; Sharkey J; Akira S; Schreiber RD; Smyth MJ. 2008. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc Natl Acad Sci U S A 105(2):652-6. [PubMed: 18178624]  [MGI Ref ID J:131026]

Takabayshi K; Corr M; Hayashi T; Redecke V; Beck L; Guiney D; Sheppard D; Raz E. 2006. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity 24(4):475-87. [PubMed: 16618605]  [MGI Ref ID J:113350]

Takeda K; Cretney E; Hayakawa Y; Ota T; Akiba H; Ogasawara K; Yagita H; Kinoshita K; Okumura K; Smyth MJ. 2005. TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver. Blood 105(5):2082-9. [PubMed: 15536146]  [MGI Ref ID J:98142]

Takeda K; Nakayama M; Sakaki M; Hayakawa Y; Imawari M; Ogasawara K; Okumura K; Smyth MJ. 2011. IFN-gamma production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice. J Leukoc Biol 90(4):777-85. [PubMed: 21712396]  [MGI Ref ID J:177544]

Takeda K; Tsutsui H; Yoshimoto T; Adachi O; Yoshida N; Kishimoto T ; Okamura H ; Nakanishi K ; Akira S. 1998. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity 8(3):383-90. [PubMed: 9529155]  [MGI Ref ID J:46514]

Taneichi M; Naito S; Kato H; Tanaka Y; Mori M; Nakano Y; Yamamura H; Ishida H; Komuro K; Uchida T. 2002. T cell-independent regulation of IgE antibody production induced by surface-linked liposomal antigen. J Immunol 169(8):4246-52. [PubMed: 12370355]  [MGI Ref ID J:120172]

Tarrant TK; Silver PB; Chan CC; Wiggert B; Caspi RR. 1998. Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis. J Immunol 161(1):122-7. [PubMed: 9647215]  [MGI Ref ID J:119208]

Teng MW; Andrews DM; McLaughlin N; von Scheidt B; Ngiow SF; Moller A; Hill GR; Iwakura Y; Oft M; Smyth MJ. 2010. IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis. Proc Natl Acad Sci U S A 107(18):8328-33. [PubMed: 20404142]  [MGI Ref ID J:160332]

Teng MW; von Scheidt B; Duret H; Towne JE; Smyth MJ. 2011. Anti-IL-23 Monoclonal Antibody Synergizes in Combination with Targeted Therapies or IL-2 to Suppress Tumor Growth and Metastases. Cancer Res 71(6):2077-86. [PubMed: 21282337]  [MGI Ref ID J:170103]

Thomas MJ; Noble A; Sawicka E; Askenase PW; Kemeny DM. 2002. CD8 T cells inhibit IgE via dendritic cell IL-12 induction that promotes Th1 T cell counter-regulation. J Immunol 168(1):216-23. [PubMed: 11751965]  [MGI Ref ID J:131005]

Town T; Bai F; Wang T; Kaplan AT; Qian F; Montgomery RR; Anderson JF; Flavell RA; Fikrig E. 2009. Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity 30(2):242-53. [PubMed: 19200759]  [MGI Ref ID J:146461]

Trembleau S; Penna G; Gregori S; Chapman HD; Serreze DV; Magram J; Adorini L. 1999. Pancreas-infiltrating Th1 cells and diabetes develop in IL-12-deficient nonobese diabetic mice. J Immunol 163(5):2960-8. [PubMed: 10453045]  [MGI Ref ID J:57084]

Tribouillard-Tanvier D; Race B; Striebel JF; Carroll JA; Phillips K; Chesebro B. 2012. Early Cytokine Elevation, PrPres Deposition, and Gliosis in Mouse Scrapie: No Effect on Disease by Deletion of Cytokine Genes IL-12p40 and IL-12p35. J Virol 86(19):10377-83. [PubMed: 22787236]  [MGI Ref ID J:187897]

Turnquist HR; Cardinal J; Macedo C; Rosborough BR; Sumpter TL; Geller DA; Metes D; Thomson AW. 2010. mTOR and GSK-3 shape the CD4+ T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS. Blood 115(23):4758-69. [PubMed: 20335217]  [MGI Ref ID J:161553]

Tyznik AJ; Tupin E; Nagarajan NA; Her MJ; Benedict CA; Kronenberg M. 2008. Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals. J Immunol 181(7):4452-6. [PubMed: 18802047]  [MGI Ref ID J:141301]

Tzelepis F; Persechini PM; Rodrigues MM. 2007. Modulation of CD4+ T cell-dependent specific cytotoxic CD8+ T cells differentiation and proliferation by the timing of increase in the pathogen load. PLoS ONE 2(4):e393. [PubMed: 17460760]  [MGI Ref ID J:129273]

Ueda N; Kuki H; Kamimura D; Sawa S; Seino K; Tashiro T; Fushuku K; Taniguchi M; Hirano T; Murakami M. 2006. CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4. Int Immunol 18(9):1397-404. [PubMed: 16914507]  [MGI Ref ID J:113387]

Van Uden JH; Tran CH; Carson DA; Raz E. 2001. Type I interferon is required to mount an adaptive response to immunostimulatory DNA. Eur J Immunol 31(11):3281-90. [PubMed: 11745345]  [MGI Ref ID J:72586]

VanLith ML; Kohlgraf KG; Sivinski CL; Tempero RM; Hollingsworth MA. 2002. MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses. Int Immunol 14(8):873-82. [PubMed: 12147624]  [MGI Ref ID J:113544]

Vitry MA; De Trez C; Goriely S; Dumoutier L; Akira S; Ryffel B; Carlier Y; Letesson JJ; Muraille E. 2012. Crucial role of gamma interferon-producing CD4+ Th1 cells but dispensable function of CD8+ T cell, B cell, Th2, and Th17 responses in the control of Brucella melitensis infection in mice. Infect Immun 80(12):4271-80. [PubMed: 23006848]  [MGI Ref ID J:190620]

Vladimer GI; Weng D; Paquette SW; Vanaja SK; Rathinam VA; Aune MH; Conlon JE; Burbage JJ; Proulx MK; Liu Q; Reed G; Mecsas JC; Iwakura Y; Bertin J; Goguen JD; Fitzgerald KA; Lien E. 2012. The NLRP12 inflammasome recognizes Yersinia pestis. Immunity 37(1):96-107. [PubMed: 22840842]  [MGI Ref ID J:187388]

Vom Berg J; Prokop S; Miller KR; Obst J; Kalin RE; Lopategui-Cabezas I; Wegner A; Mair F; Schipke CG; Peters O; Winter Y; Becher B; Heppner FL. 2012. Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline. Nat Med 18(12):1812-9. [PubMed: 23178247]  [MGI Ref ID J:194214]

Vonarbourg C; Mortha A; Bui VL; Hernandez PP; Kiss EA; Hoyler T; Flach M; Bengsch B; Thimme R; Holscher C; Honig M; Pannicke U; Schwarz K; Ware CF; Finke D; Diefenbach A. 2010. Regulated expression of nuclear receptor RORgammat confers distinct functional fates to NK cell receptor-expressing RORgammat(+) innate lymphocytes. Immunity 33(5):736-51. [PubMed: 21093318]  [MGI Ref ID J:167005]

Vossenkamper A; Struck D; Alvarado-Esquivel C; Went T; Takeda K; Akira S; Pfeffer K; Alber G; Lochner M; Forster I; Liesenfeld O. 2004. Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii, but IL-12 is dominant over IL-18 in parasite control. Eur J Immunol 34(11):3197-207. [PubMed: 15368276]  [MGI Ref ID J:93844]

Wang S; Fan Y; Han X; Yang J; Bilenki L; Yang X. 2001. IL-12-dependent vascular cell adhesion molecule-1 expression contributes to airway eosinophilic inflammation in a mouse model of asthma-like reaction. J Immunol 166(4):2741-9. [PubMed: 11160340]  [MGI Ref ID J:111001]

Wang SZ; Bao YX; Rosenberger CL; Tesfaigzi Y; Stark JM; Harrod KS. 2004. IL-12p40 and IL-18 modulate inflammatory and immune responses to respiratory syncytial virus infection. J Immunol 173(6):4040-9. [PubMed: 15356153]  [MGI Ref ID J:92751]

Wang W; Milani M; Ostlie N; Okita D; Agarwal RK; Caspi RR; Conti-Fine BM. 2007. C57BL/6 mice genetically deficient in IL-12/IL-23 and IFN-gamma are susceptible to experimental autoimmune myasthenia gravis, suggesting a pathogenic role of non-Th1 cells. J Immunol 178(11):7072-80. [PubMed: 17513756]  [MGI Ref ID J:143019]

Wang Y; Chaudhri G; Jackson RJ; Karupiah G. 2009. IL-12p40 and IL-18 play pivotal roles in orchestrating the cell-mediated immune response to a poxvirus infection. J Immunol 183(5):3324-31. [PubMed: 19657092]  [MGI Ref ID J:151861]

Way SS; Havenar-Daughton C; Kolumam GA; Orgun NN; Murali-Krishna K. 2007. IL-12 and type-I IFN synergize for IFN-gamma production by CD4 T cells, whereas neither are required for IFN-gamma production by CD8 T cells after Listeria monocytogenes infection. J Immunol 178(7):4498-505. [PubMed: 17372008]  [MGI Ref ID J:145140]

Wesley JD; Robbins SH; Sidobre S; Kronenberg M; Terrizzi S; Brossay L. 2005. Cutting edge: IFN-gamma signaling to macrophages is required for optimal Valpha14i NK T/NK cell cross-talk. J Immunol 174(7):3864-8. [PubMed: 15778340]  [MGI Ref ID J:97977]

Wieland CW; Florquin S; Pater JM; Weijer S; van der Poll T. 2006. CD4+ cells play a limited role in murine lung infection with Mycobacterium kansasii. Am J Respir Cell Mol Biol 34(2):167-73. [PubMed: 16195537]  [MGI Ref ID J:120194]

Wigginton JM; Lee JK; Wiltrout TA; Alvord WG; Hixon JA; Subleski J; Back TC; Wiltrout RH. 2002. Synergistic engagement of an ineffective endogenous anti-tumor immune response and induction of IFN-gamma and Fas-ligand-dependent tumor eradication by combined administration of IL-18 and IL-2. J Immunol 169(8):4467-74. [PubMed: 12370382]  [MGI Ref ID J:109850]

Wilson MS; Elnekave E; Mentink-Kane MM; Hodges MG; Pesce JT; Ramalingam TR; Thompson RW; Kamanaka M; Flavell RA; Keane-Myers A; Cheever AW; Wynn TA. 2007. IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice. J Clin Invest 117(10):2941-51. [PubMed: 17885690]  [MGI Ref ID J:127527]

Wilson MS; Madala SK; Ramalingam TR; Gochuico BR; Rosas IO; Cheever AW; Wynn TA. 2010. Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. J Exp Med 207(3):535-52. [PubMed: 20176803]  [MGI Ref ID J:158818]

Wozniak TM; Ryan AA; Britton WJ. 2006. Interleukin-23 restores immunity to Mycobacterium tuberculosis infection in IL-12p40-deficient mice and is not required for the development of IL-17-secreting T cell responses. J Immunol 177(12):8684-92. [PubMed: 17142769]  [MGI Ref ID J:140665]

Wuthrich M; Gern B; Hung CY; Ersland K; Rocco N; Pick-Jacobs J; Galles K; Filutowicz H; Warner T; Evans M; Cole G; Klein B. 2011. Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice. J Clin Invest 121(2):554-68. [PubMed: 21206087]  [MGI Ref ID J:171835]

Wuthrich M; Warner T; Klein BS. 2005. IL-12 is required for induction but not maintenance of protective, memory responses to Blastomyces dermatitidis: implications for vaccine development in immune-deficient hosts. J Immunol 175(8):5288-97. [PubMed: 16210634]  [MGI Ref ID J:119110]

Xiao BG; Ma CG; Xu LY; Link H; Lu CZ. 2008. IL-12/IFN-gamma/NO axis plays critical role in development of Th1-mediated experimental autoimmune encephalomyelitis. Mol Immunol 45(4):1191-6. [PubMed: 17697713]  [MGI Ref ID J:126771]

Xiao Z; Casey KA; Jameson SC; Curtsinger JM; Mescher MF. 2009. Programming for CD8 T cell memory development requires IL-12 or type I IFN. J Immunol 182(5):2786-94. [PubMed: 19234173]  [MGI Ref ID J:146256]

Xing Z; Zganiacz A; Wang J; Divangahi M; Nawaz F. 2000. IL-12-independent Th1-type immune responses to respiratory viral infection: requirement of IL-18 for IFN-gamma release in the lung but not for the differentiation of viral-reactive Th1-type lymphocytes. J Immunol 164(5):2575-84. [PubMed: 10679096]  [MGI Ref ID J:60565]

Yamamoto N; Kawakami K; Kinjo Y; Miyagi K; Kinjo T; Uezu K; Nakasone C; Nakamatsu M; Saito A. 2004. Essential role for the p40 subunit of interleukin-12 in neutrophil-mediated early host defense against pulmonary infection with Streptococcus pneumoniae: involvement of interferon-gamma. Microbes Infect 6(14):1241-9. [PubMed: 15555529]  [MGI Ref ID J:105589]

Yang CY; Best JA; Knell J; Yang E; Sheridan AD; Jesionek AK; Li HS; Rivera RR; Lind KC; D'Cruz LM; Watowich SS; Murre C; Goldrath AW. 2011. The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets. Nat Immunol 12(12):1221-9. [PubMed: 22057289]  [MGI Ref ID J:179006]

Yang CY; Leung PS; Yang GX; Kenny TP; Zhang W; Coppel R; Norman GL; Ansari AA; Mackay IR; Worman HJ; Gershwin ME. 2012. Epitope-specific anti-nuclear antibodies are expressed in a mouse model of primary biliary cirrhosis and are cytokine-dependent. Clin Exp Immunol 168(3):261-7. [PubMed: 22519587]  [MGI Ref ID J:184866]

Yap GS; Ortmann R; Shevach E; Sher A. 2001. A heritable defect in IL-12 signaling in B10.Q/J mice. II. Effect on acute resistance to Toxoplasma gondii and rescue by IL-18 treatment. J Immunol 166(9):5720-5. [PubMed: 11313414]  [MGI Ref ID J:120304]

Yarovinsky F; Kanzler H; Hieny S; Coffman RL; Sher A. 2006. Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell response. Immunity 25(4):655-64. [PubMed: 17000122]  [MGI Ref ID J:114880]

Yi AK; Yoon H; Park JE; Kim BS; Kim HJ; Martinez-Hernandez A. 2006. CpG DNA-mediated induction of acute liver injury in D-galactosamine-sensitized mice: the mitochondrial apoptotic pathway-dependent death of hepatocytes. J Biol Chem 281(21):15001-12. [PubMed: 16554296]  [MGI Ref ID J:113473]

Zaccone P; Hutchings P; Nicoletti F; Penna G; Adorini L; Cooke A. 1999. The involvement of IL-12 in murine experimentally induced autoimmune thyroid disease. Eur J Immunol 29(6):1933-42. [PubMed: 10382756]  [MGI Ref ID J:56064]

Zelante T; De Luca A; Bonifazi P; Montagnoli C; Bozza S; Moretti S; Belladonna ML; Vacca C; Conte C; Mosci P; Bistoni F; Puccetti P; Kastelein RA; Kopf M; Romani L. 2007. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur J Immunol 37(10):2695-706. [PubMed: 17899546]  [MGI Ref ID J:125340]

Zhang JH; He H; Borzychowski AM; Takeda K; Akira S; Croy BA. 2003. Analysis of cytokine regulators inducing interferon production by mouse uterine natural killer cells. Biol Reprod 69(2):404-11. [PubMed: 12646495]  [MGI Ref ID J:84561]

Zhang S; Bernard D; Khan WI; Kaplan MH; Bramson JL; Wan Y. 2009. CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis. Eur J Immunol 39(5):1252-9. [PubMed: 19338001]  [MGI Ref ID J:148099]

Zhang W; Tsuda M; Yang GX; Tsuneyama K; He XS; Ansari AA; Ridgway WM; Coppel RL; Lian ZX; Leung PS; Gershwin ME. 2012. Lymphoma-like T cell infiltration in liver is associated with increased copy number of dominant negative form of TGFbeta receptor II. PLoS One 7(11):e49413. [PubMed: 23145171]  [MGI Ref ID J:194795]

Zhang-Hoover J; Sutton A; Stein-Streilein J. 2001. CD40/CD40 ligand interactions are critical for elicitation of autoimmune-mediated fibrosis in the lung. J Immunol 166(5):3556-63. [PubMed: 11207316]  [MGI Ref ID J:126400]

Zheng Y; Valdez PA; Danilenko DM; Hu Y; Sa SM; Gong Q; Abbas AR; Modrusan Z; Ghilardi N; de Sauvage FJ; Ouyang W. 2008. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med 14(3):282-9. [PubMed: 18264109]  [MGI Ref ID J:161073]

Zhu R; Diem S; Araujo LM; Aumeunier A; Denizeau J; Philadelphe E; Damotte D; Samson M; Gourdy P; Dy M; Schneider E; Herbelin A. 2007. The Pro-Th1 cytokine IL-12 enhances IL-4 production by invariant NKT cells: relevance for T cell-mediated hepatitis. J Immunol 178(9):5435-42. [PubMed: 17442924]  [MGI Ref ID J:145840]

van Rossum AM; Lysenko ES; Weiser JN. 2005. Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun 73(11):7718-26. [PubMed: 16239576]  [MGI Ref ID J:104292]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX30

Colony Maintenance

Breeding & HusbandryThis strain is maintained by homozygous matings. Expected coat color from breeding:Black
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is an exceptional breeder.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $103.90Female or MaleHomozygous for Il12btm1Jm  
4 weeks $103.90Female or MaleHomozygous for Il12btm1Jm  
5 weeks $103.90Female or MaleHomozygous for Il12btm1Jm  
6 weeks $109.15Female or MaleHomozygous for Il12btm1Jm  
7 weeks $114.40Female or MaleHomozygous for Il12btm1Jm  
8 weeks $119.65Female or MaleHomozygous for Il12btm1Jm  
Price per Pair (US dollars $)Pair Genotype
$218.30Homozygous for Il12btm1Jm x Homozygous for Il12btm1Jm  

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Supply Notes

  • Pair Pricing: Price may vary depending on the age of the males and females available for shipment. The price displayed is for a male and female at six weeks of age.
  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $135.10Female or MaleHomozygous for Il12btm1Jm  
4 weeks $135.10Female or MaleHomozygous for Il12btm1Jm  
5 weeks $135.10Female or MaleHomozygous for Il12btm1Jm  
6 weeks $141.90Female or MaleHomozygous for Il12btm1Jm  
7 weeks $148.80Female or MaleHomozygous for Il12btm1Jm  
8 weeks $155.60Female or MaleHomozygous for Il12btm1Jm  
Price per Pair (US dollars $)Pair Genotype
$283.80Homozygous for Il12btm1Jm x Homozygous for Il12btm1Jm  

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Supply Notes

  • Pair Pricing: Price may vary depending on the age of the males and females available for shipment. The price displayed is for a male and female at six weeks of age.
  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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