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Mice homozygous for the Il12btm1Jmtargeted mutation have a severely restricted ability to mount a TH1 response to in vivo endotoxin administration while TH2 response is enhanced. Delayed type hypersensitivity (DTH) responses are reduced.


Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is an exceptional breeder.
Specieslaboratory mouse
Background Strain C57BL/6
Donor Strain 129S1 via W9.5 ES (+Kitl-SlJ)
GenerationN11F45 (14-AUG-14)
Generation Definitions
Donating InvestigatorDr. Jeanne Magram,   Boehringer Ingelheim Pharmaceuticals,Inc

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Related Genotype: a/a

Mice homozygous for the Il12btm1Jmtargeted mutation have a severely restricted ability to mount a TH1 response to in vivo endotoxin administration as evidenced by decreased interferon-gamma production although IL2 (IL-2) production is not compromised. The TH2 response is enhanced as evidenced by increased secretion of IL4 (IL-4). Delayed type hypersensitivity (DTH) responses are reduced. Also see the Il12a-deficient strains (Stock No. 002691 & 002692).

A targeting vector containing a PGK-Neo cassette was used to disrupt part of exon 3. The construct was electroporated into 129S1/Sv-Oca2+ Tyr+ Kitl+ derived W9.5 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6J blastocysts. The mice were backcrossed to C57BL/6 for 9 generations. Upon arrival at The Jackson Laboratory, the mice were crossed to CBA/J (Stock No. 000656) at least once to establish the colony.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls

Related Strains

Strains carrying   Il12btm1Jm allele
002694   C.129S1-Il12btm1Jm/J
019002   CBA.129S1(B6)-Il12btm1Jm/J
View Strains carrying   Il12btm1Jm     (2 strains)

Strains carrying other alleles of Il12b
006412   B6.129-Il12btm1Lky/J
015864   C.129S4(B6)-Il12btm1Lky/J
015863   C.129S4(B6)-Il12btm2Lky/J
009618   NOD.129(B6)-Il12btm1Lky/JbsJ
View Strains carrying other alleles of Il12b     (4 strains)


Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Asthma, Susceptibility to   (IL12B)
Immunodeficiency 29; IMD29   (IL12B)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype


  • mortality/aging
  • increased sensitivity to xenobiotic induced morbidity/mortality
    • increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls   (MGI Ref ID J:91927)
  • immune system phenotype
  • abnormal granulocyte physiology
    • fewer than expected granulocytes in the dermis of carcinogen treated skin   (MGI Ref ID J:111568)
  • abnormal lymphocyte physiology
    • lymph node cells from keyhole limpet hemocyanin (KLH) immunized mice are severely impaired in their ability to produce IFNG when cultured with KLH; however, their production of IL4 is increased   (MGI Ref ID J:120806)
    • abnormal CD8-positive, alpha-beta T cell physiology
      • dramatic increase in the number of cytotoxic CD8+ cells in the dermis and epidermis of carcinogen treated skin   (MGI Ref ID J:111568)
    • abnormal NK cell physiology
      • mean NK lytic activity is about 66% of controls; however when cultured with IL2 lytic activity is similar to controls   (MGI Ref ID J:120806)
  • abnormal macrophage physiology
    • fewer than expected macrophages in the dermis of carcinogen treated skin   (MGI Ref ID J:111568)
  • decreased circulating interferon-gamma level
    • serum levels of IFNG in LPS-injected mice are only 17 +/- 5% of LPS-induced controls   (MGI Ref ID J:120806)
  • decreased interleukin-17 secretion
    • barely detectable levels of IL17 in the skin after carcinogen treatment unlike wild-type mice which express high levels of IL17   (MGI Ref ID J:111568)
  • decreased susceptibility to type IV hypersensitivity reaction
    • specific foot pad swelling 48 hours after challenge with methylated bovine serum albumin is inhibited by 47 +/- 3% compared to wild-type mice; however, cytotoxic T lymphocyte responses are similar to wild-type   (MGI Ref ID J:120806)
  • increased susceptibility to bacterial infection
    • vaccination does not produce a protective response to M. tuberculosis   (MGI Ref ID J:120806)
  • tumorigenesis
  • decreased incidence of tumors by chemical induction
    • resistant to induction of papillomas compared to wild-type mice after treatment with DMBA and TPA in a 2 step skin carcinogenesis protocol   (MGI Ref ID J:111568)
    • however, there is an increase in the incidence of tumors following intradermal challenge with PDV squamous carcinoma cells   (MGI Ref ID J:111568)
  • homeostasis/metabolism phenotype
  • decreased circulating interferon-gamma level
    • serum levels of IFNG in LPS-injected mice are only 17 +/- 5% of LPS-induced controls   (MGI Ref ID J:120806)
  • decreased incidence of tumors by chemical induction
    • resistant to induction of papillomas compared to wild-type mice after treatment with DMBA and TPA in a 2 step skin carcinogenesis protocol   (MGI Ref ID J:111568)
    • however, there is an increase in the incidence of tumors following intradermal challenge with PDV squamous carcinoma cells   (MGI Ref ID J:111568)
  • increased sensitivity to xenobiotic induced morbidity/mortality
    • increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls   (MGI Ref ID J:91927)
  • craniofacial phenotype
  • abnormal alveolar process morphology
    • 3 fold increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks   (MGI Ref ID J:147935)
  • skeleton phenotype
  • abnormal alveolar process morphology
    • 3 fold increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks   (MGI Ref ID J:147935)
  • hematopoietic system phenotype
  • abnormal granulocyte physiology
    • fewer than expected granulocytes in the dermis of carcinogen treated skin   (MGI Ref ID J:111568)
  • abnormal lymphocyte physiology
    • lymph node cells from keyhole limpet hemocyanin (KLH) immunized mice are severely impaired in their ability to produce IFNG when cultured with KLH; however, their production of IL4 is increased   (MGI Ref ID J:120806)
    • abnormal CD8-positive, alpha-beta T cell physiology
      • dramatic increase in the number of cytotoxic CD8+ cells in the dermis and epidermis of carcinogen treated skin   (MGI Ref ID J:111568)
    • abnormal NK cell physiology
      • mean NK lytic activity is about 66% of controls; however when cultured with IL2 lytic activity is similar to controls   (MGI Ref ID J:120806)
  • abnormal macrophage physiology
    • fewer than expected macrophages in the dermis of carcinogen treated skin   (MGI Ref ID J:111568)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.


  • immune system phenotype
  • abnormal CD4-positive, alpha-beta T cell physiology
    • 75 days after infection Ifng mRNA expression in CD4+ cells is more than 50-fold lower than in wild-type   (MGI Ref ID J:34164)
    • 75 days after infection Il4 mRNA expression in CD4+ cells is 100-fold higher than in wild-type   (MGI Ref ID J:34164)
    • draining lymph node cells in L. major infected mice produce significantly more IL4 compared to IFNG in contrast to wild-type mice which express more IFNG than IL4   (MGI Ref ID J:34164)
  • decreased susceptibility to type IV hypersensitivity reaction
    • do not show any delayed type hypersensitivity response to application of Leishmania antigen to the uninfected footpad 41 days after initial infection with L. major   (MGI Ref ID J:34164)
  • increased susceptibility to parasitic infection
    • develop large lesions unlike wild-type 129S1/Sv mice after infection with Leishmania major   (MGI Ref ID J:34164)
    • 75 days after infection with L. major parasite numbers in the draining lymph nodes are increased 400-fold compared to wild-type mice   (MGI Ref ID J:34164)
  • hematopoietic system phenotype
  • abnormal CD4-positive, alpha-beta T cell physiology
    • 75 days after infection Ifng mRNA expression in CD4+ cells is more than 50-fold lower than in wild-type   (MGI Ref ID J:34164)
    • 75 days after infection Il4 mRNA expression in CD4+ cells is 100-fold higher than in wild-type   (MGI Ref ID J:34164)
    • draining lymph node cells in L. major infected mice produce significantly more IL4 compared to IFNG in contrast to wild-type mice which express more IFNG than IL4   (MGI Ref ID J:34164)


        involves: 129S1/SvImJ
  • immune system phenotype
  • abnormal T-helper 1 physiology
    • in vivo Th1 cell response is impaired as indicated by the low amounts of IFN-gamma produced by T cells in response to M. bovis antigens   (MGI Ref ID J:46514)
  • decreased interferon-gamma secretion
    • splenic T cells produce about 1/4th the amount of IFN-gamma as T cells from wild-type mice 14 days after injection with heat killed M. Bovis   (MGI Ref ID J:46514)
  • impaired natural killer cell mediated cytotoxicity
    • the killing activity of splenic NK cells is about 2/3rds that of wild-type mice as measured by in vitro co-culturing with YAC-1 target cells   (MGI Ref ID J:46514)
    • normal level of target cell killing can be restored by in vivo pretreatment with IL-18 for two days or the addition of IL-18 to the co-culture   (MGI Ref ID J:46514)
  • hematopoietic system phenotype
  • abnormal T-helper 1 physiology
    • in vivo Th1 cell response is impaired as indicated by the low amounts of IFN-gamma produced by T cells in response to M. bovis antigens   (MGI Ref ID J:46514)
  • impaired natural killer cell mediated cytotoxicity
    • the killing activity of splenic NK cells is about 2/3rds that of wild-type mice as measured by in vitro co-culturing with YAC-1 target cells   (MGI Ref ID J:46514)
    • normal level of target cell killing can be restored by in vivo pretreatment with IL-18 for two days or the addition of IL-18 to the co-culture   (MGI Ref ID J:46514)


        involves: 129S1/Sv
  • mortality/aging
  • increased susceptibility to bacterial infection induced morbidity/mortality
    • mice died before day 12 after inoculation with C. rodentium   (MGI Ref ID J:161073)
  • immune system phenotype
  • increased susceptibility to bacterial infection induced morbidity/mortality
    • mice died before day 12 after inoculation with C. rodentium   (MGI Ref ID J:161073)
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Research Applications
This mouse can be used to support research in many areas including:

Il12btm1Jm related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Il12btm1Jm
Allele Name targeted mutation 1, Jeanne Magram
Allele Type Targeted (Null/Knockout)
Common Name(s) IL-12 p40-; IL-12-; IL-12KO; IL-12btm1 Jm; IL-12p40-; IL-12p40-KO; IL12p40-; Il-12/23p40 KO; Il12b-; p40-;
Mutation Made ByDr. Jeanne Magram,   Boehringer Ingelheim Pharmaceuticals,Inc
Strain of Origin129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
ES Cell Line NameW9.5/W95
ES Cell Line Strain129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Gene Symbol and Name Il12b, interleukin 12b
Chromosome 11
Gene Common Name(s) CLMF; CLMF2; IL-12 p40; IL-12B; IL-23 subunit p40; IMD28; IMD29; Il-12b; Il-12p40; Il12; NKSF; NKSF2;
Molecular Note A neomycin resistance cassette replaced a portion of exon 3 of the gene. [MGI Ref ID J:33141]


Genotyping Information

Genotyping Protocols

Il12btm1Jmalternate2, Separated PCR
Il12btm1Jm, Separated PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Additional References

Il12btm1Jm related

Adachi K; Tsutsui H; Kashiwamura S; Seki E; Nakano H; Takeuchi O; Takeda K; Okumura K; Van Kaer L; Okamura H; Akira S; Nakanishi K. 2001. Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism. J Immunol 167(10):5928-34. [PubMed: 11698470]  [MGI Ref ID J:118004]

Akhiani AA; Pappo J; Kabok Z; Schon K; Gao W; Franzen LE; Lycke N. 2002. Protection against Helicobacter pylori infection following immunization is IL-12-dependent and mediated by Th1 cells. J Immunol 169(12):6977-84. [PubMed: 12471132]  [MGI Ref ID J:118009]

Alayan J; Ivanovski S; Farah CS. 2007. Alveolar bone loss in T helper 1/T helper 2 cytokine-deficient mice. J Periodontal Res 42(2):97-103. [PubMed: 17305866]  [MGI Ref ID J:147935]

Aliberti J; Viola JP; Vieira-de-Abreu A; Bozza PT; Sher A; Scharfstein J. 2003. Cutting edge: Bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization. J Immunol 170(11):5349-53. [PubMed: 12759407]  [MGI Ref ID J:83453]

Amprey JL; Im JS; Turco SJ; Murray HW; Illarionov PA; Besra GS; Porcelli SA; Spath GF. 2004. A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan. J Exp Med 200(7):895-904. [PubMed: 15466622]  [MGI Ref ID J:93947]

Anderson S; Shires VL; Wilson RA; Mountford AP. 1999. Formation of multinucleated giant cells in the mouse lung is promoted in the absence of interleukin-12. Am J Respir Cell Mol Biol 20(3):371-8. [PubMed: 10030834]  [MGI Ref ID J:114254]

Ariga H; Shimohakamada Y; Nakada M; Tokunaga T; Kikuchi T; Kariyone A; Tamura T; Takatsu K. 2007. Instruction of naive CD4+ T-cell fate to T-bet expression and T helper 1 development: roles of T-cell receptor-mediated signals. Immunology 122(2):210-21. [PubMed: 17490433]  [MGI Ref ID J:125688]

Askenase PW; Itakura A; Leite-de-Moraes MC; Lisbonne M; Roongapinun S; Goldstein DR; Szczepanik M. 2005. TLR-dependent IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo. J Immunol 175(10):6390-401. [PubMed: 16272291]  [MGI Ref ID J:119381]

Awoniyi M; Miller SI; Wilson CB; Hajjar AM; Smith KD. 2012. Homeostatic regulation of Salmonella-induced mucosal inflammation and injury by IL-23. PLoS One 7(5):e37311. [PubMed: 22624013]  [MGI Ref ID J:187224]

Baird JR; Fox BA; Sanders KL; Lizotte PH; Cubillos-Ruiz JR; Scarlett UK; Rutkowski MR; Conejo-Garcia JR; Fiering S; Bzik DJ. 2013. Avirulent Toxoplasma gondii Generates Therapeutic Antitumor Immunity by Reversing Immunosuppression in the Ovarian Cancer Microenvironment. Cancer Res 73(13):3842-51. [PubMed: 23704211]  [MGI Ref ID J:199114]

Barkhuizen M; Magez S; Atkinson RA; Brombacher F. 2007. Interleukin-12p70-dependent interferon- gamma production is crucial for resistance in African trypanosomiasis. J Infect Dis 196(8):1253-60. [PubMed: 17955445]  [MGI Ref ID J:145097]

Barr DP; Belz GT; Reading PC; Wojtasiak M; Whitney PG; Heath WR; Carbone FR; Brooks AG. 2007. A role for plasmacytoid dendritic cells in the rapid IL-18-dependent activation of NK cells following HSV-1 infection. Eur J Immunol 37(5):1334-42. [PubMed: 17407097]  [MGI Ref ID J:123560]

Bastos KR; Alvarez JM; Marinho CR; Rizzo LV; Lima MR. 2002. Macrophages from IL-12p40-deficient mice have a bias toward the M2 activation profile. J Leukoc Biol 71(2):271-8. [PubMed: 11818448]  [MGI Ref ID J:74693]

Bastos KR; de Deus Vieira de Moraes L; Zago CA; Marinho CR; Russo M; Alvarez JM; D'Imperio Lima MR. 2005. Analysis of the activation profile of dendritic cells derived from the bone marrow of interleukin-12/interleukin-23-deficient mice. Immunology 114(4):499-506. [PubMed: 15804287]  [MGI Ref ID J:97435]

Beattie L; Svensson M; Bune A; Brown N; Maroof A; Zubairi S; Smith KR; Kaye PM. 2010. Leishmania donovani-induced expression of signal regulatory protein alpha on Kupffer cells enhances hepatic invariant NKT-cell activation. Eur J Immunol 40(1):117-23. [PubMed: 19877019]  [MGI Ref ID J:155693]

Becher B; Durell BG; Noelle RJ. 2002. Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J Clin Invest 110(4):493-7. [PubMed: 12189243]  [MGI Ref ID J:78574]

Beenhouwer DO; Shapiro S; Feldmesser M; Casadevall A; Scharff MD. 2001. Both Th1 and Th2 Cytokines Affect the Ability of Monoclonal Antibodies To Protect Mice against Cryptococcus neoformans. Infect Immun 69(10):6445-55. [PubMed: 11553589]  [MGI Ref ID J:71570]

Belz GT; Bedoui S; Kupresanin F; Carbone FR; Heath WR. 2007. Minimal activation of memory CD8(+) T cell by tissue-derived dendritic cells favors the stimulation of naive CD8(+) T cells. Nat Immunol 8(10):1060-6. [PubMed: 17767161]  [MGI Ref ID J:125274]

Berghout J; Langlais D; Radovanovic I; Tam M; MacMicking JD; Stevenson MM; Gros P. 2013. Irf8-regulated genomic responses drive pathological inflammation during cerebral malaria. PLoS Pathog 9(7):e1003491. [PubMed: 23853600]  [MGI Ref ID J:213363]

Bielinska AU; Makidon PE; Janczak KW; Blanco LP; Swanson B; Smith DM; Pham T; Szabo Z; Kukowska-Latallo JF; Baker JR Jr. 2014. Distinct pathways of humoral and cellular immunity induced with the mucosal administration of a nanoemulsion adjuvant. J Immunol 192(6):2722-33. [PubMed: 24532579]  [MGI Ref ID J:209908]

Blazar BR; Lees CJ; Martin PJ; Noelle RJ; Kwon B; Murphy W; Taylor PA. 2000. Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions. J Immunol 165(9):4901-9. [PubMed: 11046015]  [MGI Ref ID J:118027]

Boelen A; Kwakkel J; Platvoet-ter Schiphorst M; Baur A; Kohrle J; Wiersinga WM. 2004. Contribution of interleukin-12 to the pathogenesis of non-thyroidal illness. Horm Metab Res 36(2):101-6. [PubMed: 15002060]  [MGI Ref ID J:120558]

Bombeiro AL; Goncalves LA; Penha-Goncalves C; Marinho CR; D'Imperio Lima MR; Chadi G; Alvarez JM. 2012. IL-12p40 deficiency leads to uncontrolled Trypanosoma cruzi dissemination in the spinal cord resulting in neuronal death and motor dysfunction. PLoS One 7(11):e49022. [PubMed: 23152844]  [MGI Ref ID J:195025]

Brigl M; Tatituri RV; Watts GF; Bhowruth V; Leadbetter EA; Barton N; Cohen NR; Hsu FF; Besra GS; Brenner MB. 2011. Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection. J Exp Med 208(6):1163-77. [PubMed: 21555485]  [MGI Ref ID J:177293]

Brummel R; Roberts TL; Stacey KJ; Lenert P. 2006. Higher-order CpG-DNA stimulation reveals distinct activation requirements for marginal zone and follicular B cells in lupus mice. Eur J Immunol 36(7):1951-62. [PubMed: 16791898]  [MGI Ref ID J:115797]

Burt BM; Plitas G; Stableford JA; Nguyen HM; Bamboat ZM; Pillarisetty VG; DeMatteo RP. 2008. CD11c identifies a subset of murine liver natural killer cells that responds to adenoviral hepatitis. J Leukoc Biol 84(4):1039-46. [PubMed: 18664530]  [MGI Ref ID J:140218]

Buxbaum LU; Denise H; Coombs GH; Alexander J; Mottram JC; Scott P. 2003. Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity. J Immunol 171(7):3711-7. [PubMed: 14500670]  [MGI Ref ID J:120395]

Buxbaum LU; Uzonna JE; Goldschmidt MH; Scott P. 2002. Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent. Eur J Immunol 32(11):3206-15. [PubMed: 12555666]  [MGI Ref ID J:115538]

Camoglio L; Juffermans NP; Peppelenbosch M; te Velde AA; ten Kate FJ; van Deventer SJ; Kopf M. 2002. Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis. Eur J Immunol 32(1):261-9. [PubMed: 11782017]  [MGI Ref ID J:73931]

Carlow DA; Williams MJ; Ziltener HJ. 2005. Inducing P-selectin ligand formation in CD8 T cells: IL-2 and IL-12 are active in vitro but not required in vivo. J Immunol 174(7):3959-66. [PubMed: 15778352]  [MGI Ref ID J:110004]

Case LK; Petell L; Yurkovetskiy L; Purdy A; Savage KJ; Golovkina TV. 2008. Replication of beta- and gammaretroviruses is restricted in I/LnJ mice via the same genetic mechanism. J Virol 82(3):1438-47. [PubMed: 18057254]  [MGI Ref ID J:163153]

Castilow EM; Legge KL; Varga SM. 2008. Cutting edge: Eosinophils do not contribute to respiratory syncytial virus vaccine-enhanced disease. J Immunol 181(10):6692-6. [PubMed: 18981084]  [MGI Ref ID J:140954]

Cenci E; Mencacci A; Del Sero G; Bacci A; Montagnoli C; d'Ostiani CF; Mosci P; Bachmann M; Bistoni F; Kopf M; Romani L. 1999. Interleukin-4 causes susceptibility to invasive pulmonary aspergillosis through suppression of protective type I responses. J Infect Dis 180(6):1957-68. [PubMed: 10558953]  [MGI Ref ID J:119841]

Chackerian AA; Chen SJ; Brodie SJ; Mattson JD; McClanahan TK; Kastelein RA; Bowman EP. 2006. Neutralization or absence of the interleukin-23 pathway does not compromise immunity to mycobacterial infection. Infect Immun 74(11):6092-9. [PubMed: 16923792]  [MGI Ref ID J:113448]

Chakraborty K; Zhou Z; Wakamatsu N; Guerrero-Plata A. 2012. Interleukin-12p40 modulates human metapneumovirus-induced pulmonary disease in an acute mouse model of infection. PLoS One 7(5):e37173. [PubMed: 22606349]  [MGI Ref ID J:187243]

Chan YR; Liu JS; Pociask DA; Zheng M; Mietzner TA; Berger T; Mak TW; Clifton MC; Strong RK; Ray P; Kolls JK. 2009. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J Immunol 182(8):4947-56. [PubMed: 19342674]  [MGI Ref ID J:147498]

Chang J; Cho JH; Lee SW; Choi SY; Ha SJ; Sung YC. 2004. IL-12 priming during in vitro antigenic stimulation changes properties of CD8 T cells and increases generation of effector and memory cells. J Immunol 172(5):2818-26. [PubMed: 14978082]  [MGI Ref ID J:88236]

Chang JT; Shevach EM; Segal BM. 1999. Regulation of interleukin (IL)-12 receptor beta2 subunit expression by endogenous IL-12: a critical step in the differentiation of pathogenic autoreactive T cells. J Exp Med 189(6):969-78. [PubMed: 10075980]  [MGI Ref ID J:53619]

Chen K; Wei Y; Sharp GC; Braley-Mullen H. 2001. Induction of experimental autoimmune thyroiditis in IL-12-/- mice. J Immunol 167(3):1720-7. [PubMed: 11466396]  [MGI Ref ID J:120397]

Chen L; Lei L; Zhou Z; He J; Xu S; Lu C; Chen J; Yang Z; Wu G; Yeh IT; Zhong G; Wu Y. 2013. Contribution of interleukin-12 p35 (IL-12p35) and IL-12p40 to protective immunity and pathology in mice infected with Chlamydia muridarum. Infect Immun 81(8):2962-71. [PubMed: 23753624]  [MGI Ref ID J:199835]

Chiaramonte MG; Hesse M; Cheever AW; Wynn TA. 2000. CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism. J Immunol 164(2):973-85. [PubMed: 10623847]  [MGI Ref ID J:127058]

Chiaramonte MG; Mentink-Kane M; Jacobson BA; Cheever AW; Whitters MJ; Goad ME; Wong A; Collins M; Donaldson DD; Grusby MJ; Wynn TA. 2003. Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. J Exp Med 197(6):687-701. [PubMed: 12642601]  [MGI Ref ID J:124413]

Chiodoni C; Stoppacciaro A; Sangaletti S; Gri G; Cappetti B; Koezuka Y; Colombo MP. 2001. Different requirements for alpha-galactosylceramide and recombinant IL-12 antitumor activity in the treatment of C-26 colon carcinoma hepatic metastases. Eur J Immunol 31(10):3101-10. [PubMed: 11592087]  [MGI Ref ID J:115631]

Cho JS; Pietras EM; Garcia NC; Ramos RI; Farzam DM; Monroe HR; Magorien JE; Blauvelt A; Kolls JK; Cheung AL; Cheng G; Modlin RL; Miller LS. 2010. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest 120(5):1762-73. [PubMed: 20364087]  [MGI Ref ID J:161481]

Chua WJ; Truscott SM; Eickhoff CS; Blazevic A; Hoft DF; Hansen TH. 2012. Polyclonal mucosa-associated invariant T cells have unique innate functions in bacterial infection. Infect Immun 80(9):3256-67. [PubMed: 22778103]  [MGI Ref ID J:187169]

Cobb D; Smeltz RB. 2012. Regulation of proinflammatory Th17 responses during Trypanosoma cruzi infection by IL-12 family cytokines. J Immunol 188(8):3766-73. [PubMed: 22412196]  [MGI Ref ID J:184072]

Coers J; Vance RE; Fontana MF; Dietrich WF. 2007. Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways. Cell Microbiol 9(10):2344-57. [PubMed: 17506816]  [MGI Ref ID J:148669]

Cooper AM; Kipnis A; Turner J; Magram J; Ferrante J; Orme IM. 2002. Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present. J Immunol 168(3):1322-7. [PubMed: 11801672]  [MGI Ref ID J:73949]

Cooper AM; Magram J; Ferrante J; Orme IM. 1997. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis. J Exp Med 186(1):39-45. [PubMed: 9206995]  [MGI Ref ID J:41494]

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Schulz SM; Kohler G; Schutze N; Knauer J; Straubinger RK; Chackerian AA; Witte E; Wolk K; Sabat R; Iwakura Y; Holscher C; Muller U; Kastelein RA; Alber G. 2008. Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17. J Immunol 181(11):7891-901. [PubMed: 19017979]  [MGI Ref ID J:142381]

Seki E; Tsutsui H; Tsuji NM; Hayashi N; Adachi K; Nakano H; Futatsugi-Yumikura S; Takeuchi O; Hoshino K; Akira S; Fujimoto J; Nakanishi K. 2002. Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice. J Immunol 169(7):3863-8. [PubMed: 12244183]  [MGI Ref ID J:120385]

Shafiani S; Dinh C; Ertelt JM; Moguche AO; Siddiqui I; Smigiel KS; Sharma P; Campbell DJ; Way SS; Urdahl KB. 2013. Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12. Immunity 38(6):1261-70. [PubMed: 23791647]  [MGI Ref ID J:207578]

Shen H; Iwasaki A. 2006. A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide. J Clin Invest 116(8):2237-43. [PubMed: 16878177]  [MGI Ref ID J:113124]

Shi M; Ye Z; Umeshappa KS; Moyana T; Xiang J. 2007. Alpha tumor necrosis factor contributes to CD8(+) T cell survival in the transition phase. Biochem Biophys Res Commun 360(3):702-7. [PubMed: 17618911]  [MGI Ref ID J:123025]

Simmons CP; Goncalves NS; Ghaem-Maghami M; Bajaj-Elliott M; Clare S; Neves B; Frankel G; Dougan G; MacDonald TT. 2002. Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma. J Immunol 168(4):1804-12. [PubMed: 11823513]  [MGI Ref ID J:74480]

Simmons CP; Mastroeni P; Fowler R; Ghaem-maghami M; Lycke N; Pizza M; Rappuoli R; Dougan G. 1999. MHC class I-restricted cytotoxic lymphocyte responses induced by enterotoxin-based mucosal adjuvants. J Immunol 163(12):6502-10. [PubMed: 10586042]  [MGI Ref ID J:58977]

Skok J; Poudrier J; Gray D. 1999. Dendritic cell-derived IL-12 promotes B cell induction of Th2 differentiation: a feedback regulation of Th1 development. J Immunol 163(8):4284-91. [PubMed: 10510367]  [MGI Ref ID J:119232]

Skokos D; Nussenzweig MC. 2007. CD8- DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS. J Exp Med 204(7):1525-31. [PubMed: 17576775]  [MGI Ref ID J:125873]

Smeltz RB; Chen J; Shevach EM. 2005. Transforming growth factor-beta1 enhances the interferon-gamma-dependent, interleukin-12-independent pathway of T helper 1 cell differentiation. Immunology 114(4):484-92. [PubMed: 15804285]  [MGI Ref ID J:97437]

Smith E; Zarbock A; Stark MA; Burcin TL; Bruce AC; Foley P; Ley K. 2007. IL-23 is required for neutrophil homeostasis in normal and neutrophilic mice. J Immunol 179(12):8274-9. [PubMed: 18056371]  [MGI Ref ID J:155034]

Smyth MJ; Thia KY; Street SE; Cretney E; Trapani JA; Taniguchi M; Kawano T; Pelikan SB; Crowe NY; Godfrey DI. 2000. Differential tumor surveillance by natural killer (NK) and NKT cells. J Exp Med 191(4):661-8. [PubMed: 10684858]  [MGI Ref ID J:124663]

Soares H; Waechter H; Glaichenhaus N; Mougneau E; Yagita H; Mizenina O; Dudziak D; Nussenzweig MC; Steinman RM. 2007. A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo. J Exp Med 204(5):1095-106. [PubMed: 17438065]  [MGI Ref ID J:125741]

Somigliana E; Vigano P; Filardo P; Candiani M; Vignali M; Panina-Bordignon P. 2001. Use of knockout transgenic mice in the study of endometriosis: insights from mice lacking beta(2)-microglobulin and interleukin-12p40. Fertil Steril 75(1):203-6. [PubMed: 11163839]  [MGI Ref ID J:66996]

Sonderegger I; Rohn TA; Kurrer MO; Iezzi G; Zou Y; Kastelein RA; Bachmann MF; Kopf M. 2006. Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis. Eur J Immunol 36(11):2849-56. [PubMed: 17039570]  [MGI Ref ID J:116998]

Stager S; Maroof A; Zubairi S; Sanos SL; Kopf M; Kaye PM. 2006. Distinct roles for IL-6 and IL-12p40 in mediating protection against Leishmania donovani and the expansion of IL-10+ CD4+ T cells. Eur J Immunol 36(7):1764-71. [PubMed: 16791879]  [MGI Ref ID J:115789]

Stobie L; Gurunathan S; Prussin C; Sacks DL; Glaichenhaus N; Wu CY; Seder RA. 2000. The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge. Proc Natl Acad Sci U S A 97(15):8427-32. [PubMed: 10890924]  [MGI Ref ID J:63412]

Stokes KY; Clanton EC; Gehrig JL; Granger DN. 2003. Role of interleukin 12 in hypercholesterolemia-induced inflammation. Am J Physiol Heart Circ Physiol 285(6):H2623-9. [PubMed: 12907426]  [MGI Ref ID J:108153]

Street SE; Cretney E; Smyth MJ. 2001. Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis. Blood 97(1):192-7. [PubMed: 11133760]  [MGI Ref ID J:68550]

Street SE; Trapani JA; MacGregor D; Smyth MJ. 2002. Suppression of lymphoma and epithelial malignancies effected by interferon gamma. J Exp Med 196(1):129-34. [PubMed: 12093877]  [MGI Ref ID J:77491]

Su Z; Stevenson MM. 2002. IL-12 is required for antibody-mediated protective immunity against blood-stage Plasmodium chabaudi AS malaria infection in mice. J Immunol 168(3):1348-55. [PubMed: 11801675]  [MGI Ref ID J:127287]

Swain SD; Siemsen DW; Pullen RR; Han S. 2014. CD4+ T cells and IFN-gamma are required for the development of Pneumocystis-associated pulmonary hypertension. Am J Pathol 184(2):483-93. [PubMed: 24361497]  [MGI Ref ID J:206386]

Swann JB; Vesely MD; Silva A; Sharkey J; Akira S; Schreiber RD; Smyth MJ. 2008. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc Natl Acad Sci U S A 105(2):652-6. [PubMed: 18178624]  [MGI Ref ID J:131026]

Takabayshi K; Corr M; Hayashi T; Redecke V; Beck L; Guiney D; Sheppard D; Raz E. 2006. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity 24(4):475-87. [PubMed: 16618605]  [MGI Ref ID J:113350]

Takeda K; Cretney E; Hayakawa Y; Ota T; Akiba H; Ogasawara K; Yagita H; Kinoshita K; Okumura K; Smyth MJ. 2005. TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver. Blood 105(5):2082-9. [PubMed: 15536146]  [MGI Ref ID J:98142]

Takeda K; Nakayama M; Sakaki M; Hayakawa Y; Imawari M; Ogasawara K; Okumura K; Smyth MJ. 2011. IFN-gamma production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice. J Leukoc Biol 90(4):777-85. [PubMed: 21712396]  [MGI Ref ID J:177544]

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Tribouillard-Tanvier D; Race B; Striebel JF; Carroll JA; Phillips K; Chesebro B. 2012. Early Cytokine Elevation, PrPres Deposition, and Gliosis in Mouse Scrapie: No Effect on Disease by Deletion of Cytokine Genes IL-12p40 and IL-12p35. J Virol 86(19):10377-83. [PubMed: 22787236]  [MGI Ref ID J:187897]

Turnquist HR; Cardinal J; Macedo C; Rosborough BR; Sumpter TL; Geller DA; Metes D; Thomson AW. 2010. mTOR and GSK-3 shape the CD4+ T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS. Blood 115(23):4758-69. [PubMed: 20335217]  [MGI Ref ID J:161553]

Tyznik AJ; Tupin E; Nagarajan NA; Her MJ; Benedict CA; Kronenberg M. 2008. Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals. J Immunol 181(7):4452-6. [PubMed: 18802047]  [MGI Ref ID J:141301]

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Ueda N; Kuki H; Kamimura D; Sawa S; Seino K; Tashiro T; Fushuku K; Taniguchi M; Hirano T; Murakami M. 2006. CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4. Int Immunol 18(9):1397-404. [PubMed: 16914507]  [MGI Ref ID J:113387]

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VanLith ML; Kohlgraf KG; Sivinski CL; Tempero RM; Hollingsworth MA. 2002. MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses. Int Immunol 14(8):873-82. [PubMed: 12147624]  [MGI Ref ID J:113544]

Vitry MA; De Trez C; Goriely S; Dumoutier L; Akira S; Ryffel B; Carlier Y; Letesson JJ; Muraille E. 2012. Crucial role of gamma interferon-producing CD4+ Th1 cells but dispensable function of CD8+ T cell, B cell, Th2, and Th17 responses in the control of Brucella melitensis infection in mice. Infect Immun 80(12):4271-80. [PubMed: 23006848]  [MGI Ref ID J:190620]

Vladimer GI; Weng D; Paquette SW; Vanaja SK; Rathinam VA; Aune MH; Conlon JE; Burbage JJ; Proulx MK; Liu Q; Reed G; Mecsas JC; Iwakura Y; Bertin J; Goguen JD; Fitzgerald KA; Lien E. 2012. The NLRP12 inflammasome recognizes Yersinia pestis. Immunity 37(1):96-107. [PubMed: 22840842]  [MGI Ref ID J:187388]

Vom Berg J; Prokop S; Miller KR; Obst J; Kalin RE; Lopategui-Cabezas I; Wegner A; Mair F; Schipke CG; Peters O; Winter Y; Becher B; Heppner FL. 2012. Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline. Nat Med 18(12):1812-9. [PubMed: 23178247]  [MGI Ref ID J:194214]

Vonarbourg C; Mortha A; Bui VL; Hernandez PP; Kiss EA; Hoyler T; Flach M; Bengsch B; Thimme R; Holscher C; Honig M; Pannicke U; Schwarz K; Ware CF; Finke D; Diefenbach A. 2010. Regulated expression of nuclear receptor RORgammat confers distinct functional fates to NK cell receptor-expressing RORgammat(+) innate lymphocytes. Immunity 33(5):736-51. [PubMed: 21093318]  [MGI Ref ID J:167005]

Vossenkamper A; Struck D; Alvarado-Esquivel C; Went T; Takeda K; Akira S; Pfeffer K; Alber G; Lochner M; Forster I; Liesenfeld O. 2004. Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii, but IL-12 is dominant over IL-18 in parasite control. Eur J Immunol 34(11):3197-207. [PubMed: 15368276]  [MGI Ref ID J:93844]

Wang S; Fan Y; Han X; Yang J; Bilenki L; Yang X. 2001. IL-12-dependent vascular cell adhesion molecule-1 expression contributes to airway eosinophilic inflammation in a mouse model of asthma-like reaction. J Immunol 166(4):2741-9. [PubMed: 11160340]  [MGI Ref ID J:111001]

Wang SZ; Bao YX; Rosenberger CL; Tesfaigzi Y; Stark JM; Harrod KS. 2004. IL-12p40 and IL-18 modulate inflammatory and immune responses to respiratory syncytial virus infection. J Immunol 173(6):4040-9. [PubMed: 15356153]  [MGI Ref ID J:92751]

Wang W; Milani M; Ostlie N; Okita D; Agarwal RK; Caspi RR; Conti-Fine BM. 2007. C57BL/6 mice genetically deficient in IL-12/IL-23 and IFN-gamma are susceptible to experimental autoimmune myasthenia gravis, suggesting a pathogenic role of non-Th1 cells. J Immunol 178(11):7072-80. [PubMed: 17513756]  [MGI Ref ID J:143019]

Wang Y; Chaudhri G; Jackson RJ; Karupiah G. 2009. IL-12p40 and IL-18 play pivotal roles in orchestrating the cell-mediated immune response to a poxvirus infection. J Immunol 183(5):3324-31. [PubMed: 19657092]  [MGI Ref ID J:151861]

Way SS; Havenar-Daughton C; Kolumam GA; Orgun NN; Murali-Krishna K. 2007. IL-12 and type-I IFN synergize for IFN-gamma production by CD4 T cells, whereas neither are required for IFN-gamma production by CD8 T cells after Listeria monocytogenes infection. J Immunol 178(7):4498-505. [PubMed: 17372008]  [MGI Ref ID J:145140]

Wesley JD; Robbins SH; Sidobre S; Kronenberg M; Terrizzi S; Brossay L. 2005. Cutting edge: IFN-gamma signaling to macrophages is required for optimal Valpha14i NK T/NK cell cross-talk. J Immunol 174(7):3864-8. [PubMed: 15778340]  [MGI Ref ID J:97977]

Wieland CW; Florquin S; Pater JM; Weijer S; van der Poll T. 2006. CD4+ cells play a limited role in murine lung infection with Mycobacterium kansasii. Am J Respir Cell Mol Biol 34(2):167-73. [PubMed: 16195537]  [MGI Ref ID J:120194]

Wigginton JM; Lee JK; Wiltrout TA; Alvord WG; Hixon JA; Subleski J; Back TC; Wiltrout RH. 2002. Synergistic engagement of an ineffective endogenous anti-tumor immune response and induction of IFN-gamma and Fas-ligand-dependent tumor eradication by combined administration of IL-18 and IL-2. J Immunol 169(8):4467-74. [PubMed: 12370382]  [MGI Ref ID J:109850]

Wilson MS; Elnekave E; Mentink-Kane MM; Hodges MG; Pesce JT; Ramalingam TR; Thompson RW; Kamanaka M; Flavell RA; Keane-Myers A; Cheever AW; Wynn TA. 2007. IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice. J Clin Invest 117(10):2941-51. [PubMed: 17885690]  [MGI Ref ID J:127527]

Wilson MS; Madala SK; Ramalingam TR; Gochuico BR; Rosas IO; Cheever AW; Wynn TA. 2010. Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. J Exp Med 207(3):535-52. [PubMed: 20176803]  [MGI Ref ID J:158818]

Wozniak TM; Ryan AA; Britton WJ. 2006. Interleukin-23 restores immunity to Mycobacterium tuberculosis infection in IL-12p40-deficient mice and is not required for the development of IL-17-secreting T cell responses. J Immunol 177(12):8684-92. [PubMed: 17142769]  [MGI Ref ID J:140665]

Wuthrich M; Gern B; Hung CY; Ersland K; Rocco N; Pick-Jacobs J; Galles K; Filutowicz H; Warner T; Evans M; Cole G; Klein B. 2011. Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice. J Clin Invest 121(2):554-68. [PubMed: 21206087]  [MGI Ref ID J:171835]

Wuthrich M; Warner T; Klein BS. 2005. IL-12 is required for induction but not maintenance of protective, memory responses to Blastomyces dermatitidis: implications for vaccine development in immune-deficient hosts. J Immunol 175(8):5288-97. [PubMed: 16210634]  [MGI Ref ID J:119110]

Xiao BG; Ma CG; Xu LY; Link H; Lu CZ. 2008. IL-12/IFN-gamma/NO axis plays critical role in development of Th1-mediated experimental autoimmune encephalomyelitis. Mol Immunol 45(4):1191-6. [PubMed: 17697713]  [MGI Ref ID J:126771]

Xiao Z; Casey KA; Jameson SC; Curtsinger JM; Mescher MF. 2009. Programming for CD8 T cell memory development requires IL-12 or type I IFN. J Immunol 182(5):2786-94. [PubMed: 19234173]  [MGI Ref ID J:146256]

Xing Z; Zganiacz A; Wang J; Divangahi M; Nawaz F. 2000. IL-12-independent Th1-type immune responses to respiratory viral infection: requirement of IL-18 for IFN-gamma release in the lung but not for the differentiation of viral-reactive Th1-type lymphocytes. J Immunol 164(5):2575-84. [PubMed: 10679096]  [MGI Ref ID J:60565]

Yamamoto N; Kawakami K; Kinjo Y; Miyagi K; Kinjo T; Uezu K; Nakasone C; Nakamatsu M; Saito A. 2004. Essential role for the p40 subunit of interleukin-12 in neutrophil-mediated early host defense against pulmonary infection with Streptococcus pneumoniae: involvement of interferon-gamma. Microbes Infect 6(14):1241-9. [PubMed: 15555529]  [MGI Ref ID J:105589]

Yang CY; Best JA; Knell J; Yang E; Sheridan AD; Jesionek AK; Li HS; Rivera RR; Lind KC; D'Cruz LM; Watowich SS; Murre C; Goldrath AW. 2011. The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets. Nat Immunol 12(12):1221-9. [PubMed: 22057289]  [MGI Ref ID J:179006]

Yang CY; Leung PS; Yang GX; Kenny TP; Zhang W; Coppel R; Norman GL; Ansari AA; Mackay IR; Worman HJ; Gershwin ME. 2012. Epitope-specific anti-nuclear antibodies are expressed in a mouse model of primary biliary cirrhosis and are cytokine-dependent. Clin Exp Immunol 168(3):261-7. [PubMed: 22519587]  [MGI Ref ID J:184866]

Yap GS; Ortmann R; Shevach E; Sher A. 2001. A heritable defect in IL-12 signaling in B10.Q/J mice. II. Effect on acute resistance to Toxoplasma gondii and rescue by IL-18 treatment. J Immunol 166(9):5720-5. [PubMed: 11313414]  [MGI Ref ID J:120304]

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Yi AK; Yoon H; Park JE; Kim BS; Kim HJ; Martinez-Hernandez A. 2006. CpG DNA-mediated induction of acute liver injury in D-galactosamine-sensitized mice: the mitochondrial apoptotic pathway-dependent death of hepatocytes. J Biol Chem 281(21):15001-12. [PubMed: 16554296]  [MGI Ref ID J:113473]

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Zelante T; De Luca A; Bonifazi P; Montagnoli C; Bozza S; Moretti S; Belladonna ML; Vacca C; Conte C; Mosci P; Bistoni F; Puccetti P; Kastelein RA; Kopf M; Romani L. 2007. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur J Immunol 37(10):2695-706. [PubMed: 17899546]  [MGI Ref ID J:125340]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX30

Colony Maintenance

Breeding & HusbandryThis strain is maintained by homozygous matings. Expected coat color from breeding:Black
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is an exceptional breeder.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $111.20Female or MaleHomozygous for Il12btm1Jm  
4 weeks $111.20Female or MaleHomozygous for Il12btm1Jm  
5 weeks $111.20Female or MaleHomozygous for Il12btm1Jm  
6 weeks $116.65Female or MaleHomozygous for Il12btm1Jm  
7 weeks $122.10Female or MaleHomozygous for Il12btm1Jm  
8 weeks $127.55Female or MaleHomozygous for Il12btm1Jm  
Price per Pair (US dollars $)Pair Genotype
$233.30Homozygous for Il12btm1Jm x Homozygous for Il12btm1Jm  

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Supply Notes

  • Pair Pricing: Price may vary depending on the age of the males and females available for shipment. The price displayed is for a male and female at six weeks of age.
  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $144.60Female or MaleHomozygous for Il12btm1Jm  
4 weeks $144.60Female or MaleHomozygous for Il12btm1Jm  
5 weeks $144.60Female or MaleHomozygous for Il12btm1Jm  
6 weeks $151.70Female or MaleHomozygous for Il12btm1Jm  
7 weeks $158.80Female or MaleHomozygous for Il12btm1Jm  
8 weeks $165.90Female or MaleHomozygous for Il12btm1Jm  
Price per Pair (US dollars $)Pair Genotype
$303.30Homozygous for Il12btm1Jm x Homozygous for Il12btm1Jm  

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Supply Notes

  • Pair Pricing: Price may vary depending on the age of the males and females available for shipment. The price displayed is for a male and female at six weeks of age.
  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.