Strain Name:

FVB;129P-Fmr1tm1Cgr/J

Stock Number:

002700

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Availability:

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Specieslaboratory mouse
 
Donating InvestigatorDr. Ben Oostra,   Erasmus University

Description
Mice homozygous for the Fmr1tm1Cg targeted mutation show macroorchidism (enlarged testes), learning deficits, and hyperactivity. Macroorchidism in caused by an increased rate of Sertoli cell proliferation during embryogenesis which may be independent of FSH signalling. Comparison of homozygotes to wildtype littermates in hidden- and visible-platform water maze learning showed deficits in spatial learning and motor performance.

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Fmr1tm1Cgr allele
003025   B6.129P2-Fmr1tm1Cgr/J
003024   FVB.129P2(B6)-Fmr1tm1Cgr/J
004624   FVB.129P2-Pde6b+ Tyrc-ch Fmr1tm1Cgr/J
View Strains carrying   Fmr1tm1Cgr     (3 strains)

Strains carrying other alleles of Fmr1
010504   B6.129-Fmr1tm1Rbd/J
008909   FVB.129-Fmr1tm1Rbd/J
View Strains carrying other alleles of Fmr1     (2 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Fragile X Mental Retardation Syndrome
- Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).
Autism
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Fragile X Tremor/Ataxia Syndrome; FXTAS   (FMR1)
Premature Ovarian Failure 1; POF1   (FMR1)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Fmr1tm1Cgr/Y

        either: FVB.129P2(B6)-Fmr1tm1Cgr/J or FVB;129P2(B6)-Fmr1tm1Cgr/J
  • behavior/neurological phenotype
  • audiogenic seizures
    • loud (115 dB) sound results in seizures   (MGI Ref ID J:85912)
    • seizures begin within 20-30 seconds and are characterized by wild running, erratic leaping, clonic convulsions and progress to tonic hindlimb extension, respiratory arrest and death   (MGI Ref ID J:85912)
    • seizures are age dependent and are not fully penetrant   (MGI Ref ID J:85912)
    • no seizures occur before 10 weeks of age   (MGI Ref ID J:85912)
    • 57% of mice exhibit seizures between 10-12 weeks; 70% of mice exhibit seizures between 20-34 weeks of age   (MGI Ref ID J:85912)
  • decreased startle reflex   (MGI Ref ID J:85912)
  • nervous system phenotype
  • audiogenic seizures
    • loud (115 dB) sound results in seizures   (MGI Ref ID J:85912)
    • seizures begin within 20-30 seconds and are characterized by wild running, erratic leaping, clonic convulsions and progress to tonic hindlimb extension, respiratory arrest and death   (MGI Ref ID J:85912)
    • seizures are age dependent and are not fully penetrant   (MGI Ref ID J:85912)
    • no seizures occur before 10 weeks of age   (MGI Ref ID J:85912)
    • 57% of mice exhibit seizures between 10-12 weeks; 70% of mice exhibit seizures between 20-34 weeks of age   (MGI Ref ID J:85912)
  • increased prepulse inhibition
    • both a low (75 dB) and higher (85 dB) prepulse inhibits startle response more efficiently as compared to wild-type   (MGI Ref ID J:85912)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Fmr1tm1Cgr/Fmr1tm1Cgr

        involves: 129P2/OlaHsd * C57BL/6J
  • behavior/neurological phenotype
  • hyperactivity
    • mutants show significantly more crossings through three infrared beams in an empty cage over 40 min   (MGI Ref ID J:19220)
  • increased exploration in new environment
    • mutants exhibit more exploratory behavior than controls, displaying more line crossings in the lit compartment   (MGI Ref ID J:19220)

Fmr1tm1Cgr/Fmr1tm1Cgr

        involves: 129P2/OlaHsd
  • behavior/neurological phenotype
  • increased startle reflex
    • in all eye blink conditioning training session the percentage and peak amplitudes of the startle responses were higher   (MGI Ref ID J:101021)
  • nervous system phenotype
  • abnormal Purkinje cell morphology
    • the percentage of single climbing fiber innervation is increased, the length of spine heads and necks is increased, and spines are more irregular   (MGI Ref ID J:101021)
  • abnormal dentate gyrus morphology
    • increased volume of the dentate gyrus (DG) in mutant mice   (MGI Ref ID J:159211)
  • abnormal long term depression
    • induction of long term depression in Purkinje cells is significantly enhanced when stimulating parallel fibers   (MGI Ref ID J:101021)
  • abnormal neuron differentiation
    • 60.4% decrease in neuronal differentiation compared with wild-type isolated adult neural progenitor/stem cells (aNPCs)   (MGI Ref ID J:159211)
    • 74.9% increase in astrocyte differentiation compared with wild-type isolated adult neural progenitor/stem cells (aNPCs)   (MGI Ref ID J:159211)
    • exogenously expressed wild-type gene, but not mutant (I304N) rescues both the neuronal and the astrocyte differentiation deficits in homozygous mutant cells   (MGI Ref ID J:159211)
    • reduced (10.4% ) neuronal differentiation but greater (75.7%) glial differentiation in aNPCs residing in the DG compared with wild-type mice   (MGI Ref ID J:159211)
  • abnormal neuronal precursor proliferation
    • increased proliferation of isolated aNPCs from both the forebrain and DG of adult homozygous mice   (MGI Ref ID J:159211)
    • 11% more cells in mitotic (G2/M) phase compared with wild-type controls   (MGI Ref ID J:159211)
    • increased proliferation of both stem and progenitor cells in the DG and subventricular zone of mutant mice   (MGI Ref ID J:159211)
    • normal proliferation of astrocytes in the DG of mutant mice   (MGI Ref ID J:159211)
  • cellular phenotype
  • abnormal neuron differentiation
    • 60.4% decrease in neuronal differentiation compared with wild-type isolated adult neural progenitor/stem cells (aNPCs)   (MGI Ref ID J:159211)
    • 74.9% increase in astrocyte differentiation compared with wild-type isolated adult neural progenitor/stem cells (aNPCs)   (MGI Ref ID J:159211)
    • exogenously expressed wild-type gene, but not mutant (I304N) rescues both the neuronal and the astrocyte differentiation deficits in homozygous mutant cells   (MGI Ref ID J:159211)
    • reduced (10.4% ) neuronal differentiation but greater (75.7%) glial differentiation in aNPCs residing in the DG compared with wild-type mice   (MGI Ref ID J:159211)
  • abnormal neuronal precursor proliferation
    • increased proliferation of isolated aNPCs from both the forebrain and DG of adult homozygous mice   (MGI Ref ID J:159211)
    • 11% more cells in mitotic (G2/M) phase compared with wild-type controls   (MGI Ref ID J:159211)
    • increased proliferation of both stem and progenitor cells in the DG and subventricular zone of mutant mice   (MGI Ref ID J:159211)
    • normal proliferation of astrocytes in the DG of mutant mice   (MGI Ref ID J:159211)

Fmr1tm1Cgr/Fmr1tm1Cgr

        B6.129P2-Fmr1tm1Cgr
  • reproductive system phenotype
  • increased testis weight   (MGI Ref ID J:171292)
    • testes are significantly heavier than wild-type   (MGI Ref ID J:119166)
  • behavior/neurological phenotype
  • *normal* behavior/neurological phenotype
    • mice on the C57BL/6 background, but not the FVB/NJ background, location of hidden escape platform in water maze after 6 days of training   (MGI Ref ID J:119166)
    • abnormal object recognition memory
      • mice exhibit reduced novel object recognition compared with wild-type mice   (MGI Ref ID J:171292)
    • decreased aggression towards mice
      • mice exhibit less social dominance compared with wild-type mice   (MGI Ref ID J:171292)
    • hyperactivity   (MGI Ref ID J:171292)
    • impaired conditioned place preference behavior
      • for a scent-paired chamber   (MGI Ref ID J:171292)
    • increased vertical activity   (MGI Ref ID J:171292)
  • growth/size/body phenotype
  • increased body weight   (MGI Ref ID J:171292)
  • endocrine/exocrine gland phenotype
  • increased testis weight   (MGI Ref ID J:171292)
    • testes are significantly heavier than wild-type   (MGI Ref ID J:119166)

Fmr1tm1Cgr/Y

        involves: 129P2/OlaHsd * C57BL/6 * FVB
  • behavior/neurological phenotype
  • audiogenic seizures
    • 72% of mice have a seizure in response to the test tone   (MGI Ref ID J:127792)
  • impaired passive avoidance behavior
    • mice exhibit reduced latency to enter box 24 hours after initiation of inhibitory avoidance test as compared to wildtype (inhibitory avoidance extinction behavior)   (MGI Ref ID J:127792)
  • nervous system phenotype
  • abnormal dendrite morphology
    • dendritic spine density is increased in comparison to wildtype   (MGI Ref ID J:127792)
    • abnormal dendritic spine morphology
      • density of dendritic spines along apical dendrites of layer V pyramidal cells is increased   (MGI Ref ID J:70399)
      • dendritic spine length is increased   (MGI Ref ID J:70399)
      • mice have fewer short mushroom-shaped spines than wild-type   (MGI Ref ID J:70399)
      • elongated spines are more prevalent in mutant mice   (MGI Ref ID J:70399)
  • abnormal nerve fiber response
    • brief monocular deprivation results in substantial open-eye potentiation rather than the expected deprived-eye depression   (MGI Ref ID J:127792)
  • audiogenic seizures
    • 72% of mice have a seizure in response to the test tone   (MGI Ref ID J:127792)
  • growth/size/body phenotype
  • increased body weight
    • 10% increase in body weight is observed by postnatal day 26, but is similar to wildtype by day 45   (MGI Ref ID J:127792)
  • endocrine/exocrine gland phenotype
  • increased testis weight
    • increase in weight is only observed in adult (11-12 weeks)   (MGI Ref ID J:127792)
  • reproductive system phenotype
  • increased testis weight
    • increase in weight is only observed in adult (11-12 weeks)   (MGI Ref ID J:127792)

Fmr1tm1Cgr/Y

        involves: 129P2/OlaHsd * C57BL/6J
  • behavior/neurological phenotype
  • abnormal spatial learning
    • mutants do not seem to be impaired in the retrieval of spatial and nonspatial information in training and reversal trials once this information has been learned, but they are impaired in their acquisition of the reversal task   (MGI Ref ID J:19220)
  • hyperactivity
    • mutants show significantly more crossings through three infrared beams in an empty cage over 40 min   (MGI Ref ID J:19220)
  • increased exploration in new environment
    • mutants exhibit more exploratory behavior than controls, displaying more line crossings in the lit compartment   (MGI Ref ID J:19220)
  • endocrine/exocrine gland phenotype
  • enlarged testis
    • macroorchidism develops over time   (MGI Ref ID J:19220)
    • increased testis weight
      • weight of testis increases over time, however no structural abnormalities are observed   (MGI Ref ID J:19220)
  • reproductive system phenotype
  • enlarged testis
    • macroorchidism develops over time   (MGI Ref ID J:19220)
    • increased testis weight
      • weight of testis increases over time, however no structural abnormalities are observed   (MGI Ref ID J:19220)

Fmr1tm1Cgr/Y

        involves: 129P2/OlaHsd
  • behavior/neurological phenotype
  • abnormal eye blink conditioning behavior
    • the percentage of conditioned responses was reduced in the 2nd - 4th training sessions and peak amplitude and peak velocity were reduced in the 3rd and 4th training sessions   (MGI Ref ID J:101021)
  • abnormal spatial learning
    • in the reversal trials of the Morris water maze, mutants take more time to escape to the platform than controls   (MGI Ref ID J:34449)
  • increased startle reflex
    • in all eye blink conditioning training session the percentage and peak amplitudes of the startle responses were higher   (MGI Ref ID J:101021)
  • endocrine/exocrine gland phenotype
  • enlarged testis
    • progressive enlargement resulting in testes that were 34% bigger than those of wild-type by 168-170 days of age   (MGI Ref ID J:34449)
    • macroorchidism decreases somewhat after 168-170 days of age   (MGI Ref ID J:34449)
    • increased testis weight   (MGI Ref ID J:34449)
  • reproductive system phenotype
  • enlarged testis
    • progressive enlargement resulting in testes that were 34% bigger than those of wild-type by 168-170 days of age   (MGI Ref ID J:34449)
    • macroorchidism decreases somewhat after 168-170 days of age   (MGI Ref ID J:34449)
    • increased testis weight   (MGI Ref ID J:34449)
  • nervous system phenotype
  • abnormal Purkinje cell morphology
    • the percentage of single climbing fiber innervation is increased, the length of spine heads and necks is increased, and spines are more irregular   (MGI Ref ID J:101021)
  • abnormal long term depression
    • induction of long term depression in Purkinje cells is significantly enhanced when stimulating parallel fibers   (MGI Ref ID J:101021)

Fmr1tm1Cgr/Y

        involves: 129P2/OlaHsd * FVB
  • behavior/neurological phenotype
  • convulsive seizures
    • some mice exhibit bilateral motor seizures that range from head twitching to forelimb and hindlimb clonus, loss of postural control and tonic twisting of head and torso   (MGI Ref ID J:113177)
    • tonic-clonic seizures
      • observed in some mice   (MGI Ref ID J:113177)
  • decreased anxiety-related response
    • total number of entries in arms of elevated plus maze was significantly decreased as compared to littermate control in one of the two cohorts tested   (MGI Ref ID J:151144)
  • impaired coordination
    • mice on the C57BL/6 background have longer latencies on the rotarod test than mice on the mixed FVB and 129P2 background, however, the difference between mutant and control on the mixed FVB and 129P2 background is not significant   (MGI Ref ID J:151144)
  • increased anxiety-related response
    • percentage of entries and percentage of time spent in arms of elevated plus maze is significantly increased as compared to Fmr1tm1Cgr mice on the C57BL/6 background, however, the difference between mutant and control on the mixed FVB and 129P2 background is not significant   (MGI Ref ID J:151144)
    • distance traveled in open field test is increased as compared to control   (MGI Ref ID J:151144)
  • increased exploration in new environment
    • distance traveled in open field test is increased as compared to control   (MGI Ref ID J:151144)
  • social withdrawal
    • mice spend more time in an empty cage than in a cage with a strange mouse in sociability choice test   (MGI Ref ID J:151144)
  • growth/size/body phenotype
  • increased body weight
    • body weight was significantly increased in one of the two cohorts tested   (MGI Ref ID J:151144)
  • nervous system phenotype
  • abnormal hippocampal mossy fiber morphology
    • density of Timm granules (Timm staining identifies neural elements that contain heavy metals) in zinc-rich mossy fiber terminals is increased in inner molecular layer and close to the hilus in the stratum oriens   (MGI Ref ID J:113177)
  • convulsive seizures
    • some mice exhibit bilateral motor seizures that range from head twitching to forelimb and hindlimb clonus, loss of postural control and tonic twisting of head and torso   (MGI Ref ID J:113177)
    • tonic-clonic seizures
      • observed in some mice   (MGI Ref ID J:113177)
  • vision/eye phenotype
  • *normal* vision/eye phenotype   (MGI Ref ID J:151144)
    • mice are wild-type at the Pde6b locus and are therefore not blind   (MGI Ref ID J:113177)

Fmr1tm1Cgr/Y

        FVB.129P2(B6)-Fmr1tm1Cgr/J
  • behavior/neurological phenotype
  • decreased startle reflex
    • startle response development is normal (at 118 dB) until 3-4 weeks of age, but does not increase as compared to controls   (MGI Ref ID J:113024)

Fmr1tm1Cgr/Y

        FVB.129P2(B6)-Pde6b+ Fmr1tm1Cgr
  • behavior/neurological phenotype
  • abnormal associative learning   (MGI Ref ID J:100197)
    • impaired cued conditioning behavior
      • mice exhibit reduced freezing compared to controls following CS-US pairings in trace fear conditioning paradigm   (MGI Ref ID J:100197)
      • mice exhibit reduced average freezing within the intertrial intervals   (MGI Ref ID J:100197)
      • there are no significant differences in locomotor activity, nociceptive responses and anxiety-like behaviors between mutants and controls   (MGI Ref ID J:100197)
  • nervous system phenotype
  • reduced long term potentiation
    • synaptic potentiation is blocked in anterior cingulated cortex (ACC) and lateral amygdala (LA) as determined by whole cell patch-clamp recordings,   (MGI Ref ID J:100197)
    • however, short-term synaptic plasticity and basal synaptic transmission are normal   (MGI Ref ID J:100197)
  • vision/eye phenotype
  • *normal* vision/eye phenotype
    • mice are wild-type for Pde6b and therefore sighted   (MGI Ref ID J:100197)

Fmr1tm1Cgr/Y

        FVB.129P2-Pde6b+ Tyrc-ch Fmr1tm1Cgr/J
  • behavior/neurological phenotype
  • abnormal locomotor activation
    • overall locomotor activity is increased as compared to wild-type   (MGI Ref ID J:171069)
    • mice on the FVB background are more active as compared to mice on the C57BL/6 background   (MGI Ref ID J:171069)
  • abnormal response to novelty
    • mice do not explore the novelty stimulus mouse in the social novelty preference test   (MGI Ref ID J:171069)
    • mice on the C57BL/6 background, but not the FVB background, exhibit an increased tendency to attack a juvenile stimulus mouse   (MGI Ref ID J:171069)
    • increased exploration in new environment
      • levels of spontaneous alternation and entries into maze arms are increased on the FVB background as compared to the C57BL/6 background   (MGI Ref ID J:171069)
      • however, exploration does not differ between mutant and wild-type   (MGI Ref ID J:171069)
  • abnormal social investigation
    • mice do not explore the novelty stimulus mouse in the social novelty preference test   (MGI Ref ID J:171069)
    • mice spend less time in non-social activities; the effect is more pronounced on the FVB background as compared to C57BL/6   (MGI Ref ID J:171069)
    • mice spend less time in affiliative behaviors; the effect is more pronounced on the C57BL/6 background as compared to FVB   (MGI Ref ID J:171069)
  • abnormal vocalization
    • mice exhibit an increase in the number of vocalization and duration on FVB background as compared to the C57BL/6 background   (MGI Ref ID J:171069)
  • decreased startle reflex
    • startle response is less prominent with increased pulse intensity as compared to wild-type   (MGI Ref ID J:171069)
    • mice on the C57BL/6 background exhibit stronger responses to 100 dBa pulse and lower responses to the 120 dBa pulse as compared to FVB   (MGI Ref ID J:171069)
  • nervous system phenotype
  • increased prepulse inhibition
    • magnitude of prepulse inhibition is enhanced although the effect is more prominent on the C57BL/6 background as compared to the FVB background   (MGI Ref ID J:171069)

Fmr1tm1Cgr/Y

        B6.129P2-Fmr1tm1Cgr/Nwu
  • behavior/neurological phenotype
  • *normal* behavior/neurological phenotype
    • levels of spontaneous alternation and entries into maze arms are increased on the FVB background as compared to the C57BL/6 background, however, exploration does not differ between mutant and wild-type   (MGI Ref ID J:171069)
    • mice exhibit an increase in the number of vocalization and duration on FVB background as compared to the C57BL/6 background   (MGI Ref ID J:171069)
    • abnormal locomotor activation
      • overall locomotor activity is increased as compared to wild-type   (MGI Ref ID J:171069)
      • mice on the FVB background are more active as compared to the C57BL/6 background   (MGI Ref ID J:171069)
    • abnormal response to novelty
      • mice do not preferentially explore the novelty stimulus mouse as compared to the familiar mouse in the social novelty preference test   (MGI Ref ID J:171069)
    • abnormal social investigation
      • mice do not preferentially explore the novelty stimulus mouse as compared to the familiar mouse in the social novelty preference test   (MGI Ref ID J:171069)
      • mice spend less time in non-social activities; the effect is more pronounced on the FVB background as compared to C57BL/6   (MGI Ref ID J:171069)
      • mice spend less time in affiliative behaviors; the effect is more pronounced on the C57BL/6 background as compared to FVB   (MGI Ref ID J:171069)
    • decreased startle reflex
      • startle response is less prominent with increased pulse intensity as compared to wild-type   (MGI Ref ID J:171069)
      • mice on the C57BL/6 background exhibit stronger responses to 100 dBa pulse and lower responses to the 120 dBa pulse as compared to FVB   (MGI Ref ID J:171069)
    • increased aggression towards mice
      • mice on the C57BL/6 background, but not the FVB background, exhibit an increased tendency to attack a juvenile stimulus mouse   (MGI Ref ID J:171069)
    • increased grooming behavior
      • mice spend more time self-grooming; the effect is more pronounced on the C57BL/6 background as compared to the FVB background   (MGI Ref ID J:171069)
  • nervous system phenotype
  • increased prepulse inhibition
    • magnitude of prepulse inhibition is enhanced although the effect is more prominent on the C57BL/6 background as compared to the FVB background   (MGI Ref ID J:171069)

Fmr1tm1Cgr/Y

        involves: 129P2/OlaHsd * FVB/NJ
  • behavior/neurological phenotype
  • abnormal spatial learning
    • mice do not learn location of hidden escape platform in water maze after 6 days of training   (MGI Ref ID J:119166)
    • in contrast, mice on the C57BL/6 background learned platform location and performed similar to wild-type   (MGI Ref ID J:119166)
  • endocrine/exocrine gland phenotype
  • increased testis weight
    • testes are significantly heavier than wild-type   (MGI Ref ID J:119166)
  • vision/eye phenotype
  • *normal* vision/eye phenotype
    • mice have at least one wild-type allele of Pde6b and therefore lack vison impairments commonly seen in FVB mice   (MGI Ref ID J:119166)
  • reproductive system phenotype
  • increased testis weight
    • testes are significantly heavier than wild-type   (MGI Ref ID J:119166)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Fmr1tm1Cgr related

Developmental Biology Research
Internal/Organ Defects
      multiple

Neurobiology Research
Behavioral and Learning Defects
Fragile X Mental Retardation Syndrome

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Fmr1tm1Cgr
Allele Name targeted mutation 1, Ben Oostra
Allele Type Targeted (Null/Knockout)
Common Name(s) FMRP KO; Fmr1 KO; Fmr1tm4Cgr; FraX; fmr-tm1Cgr;
Mutation Made ByDr. Ben Oostra,   Erasmus University
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Fmr1, fragile X mental retardation syndrome 1
Chromosome X
Gene Common Name(s) FMRP; FRAXA; Fmr-1; POF; POF1;
General Note Genbank: AF179463 and AF170530
Molecular Note A neomycin resistance gene was inserted into exon 5. RT-PCR analysis on testis RNA derived from hemizygous male mice demonstrated that no detectable transcript was produced from this allele, and western blot analysis on extracts of testes, liver, kidneyand brain of hemizygous male mice confirmed that no stable encoded protein was made. [MGI Ref ID J:19220]

Genotyping

Genotyping Information

Genotyping Protocols

Fmr1tm1Cgr,

Separated MCA


Fmr1tm1Cgr, Melt Curve Analysis
Fmr1tm1Cgr, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Bakker CE; Verheij C; Willemsen R; Vanderhelm R; Oerlemans F; Vermey M; Bygrave A; Hoogeveen AT; Oostra BA; Reyniers E; Deboulle K; Dhooge R; Cras P; Vanvelzen D; Nagels G; Martin JJ; Dedyn PP; Darby JK; Willems PJ; The Dutch-Belgium Fragile X Consortium. 1994. Fmr1 knockout mice: a model to study fragile x mental retardation. The Dutch-Belgium Fragile X Consortium Cell 78(1):23-33. [PubMed: 8033209]  [MGI Ref ID J:19220]

Additional References

Chen L; Toth M. 2001. Fragile X mice develop sensory hyperreactivity to auditory stimuli. Neuroscience 103(4):1043-50. [PubMed: 11301211]  [MGI Ref ID J:85912]

Comery TA; Harris JB; Willems PJ; Oostra BA; Irwin SA; Weiler IJ; Greenough WT. 1997. Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits. Proc Natl Acad Sci U S A 94(10):5401-4. [PubMed: 9144249]  [MGI Ref ID J:70399]

Godfraind JM; Reyniers E; De Boulle K; D'Hooge R; De Deyn PP; Bakker CE; Oostra BA; Kooy RF; Willems PJ. 1996. Long-term potentiation in the hippocampus of fragile X knockout mice. Am J Med Genet 64(2):246-51. [PubMed: 8844057]  [MGI Ref ID J:34552]

Kooy RF; D'Hooge R; Reyniers E; Bakker CE; Nagels G; De Boulle K; Storm K; Clincke G; De Deyn PP; Oostra BA; Willems PJ. 1996. Transgenic mouse model for the fragile X syndrome. Am J Med Genet 64(2):241-5. [PubMed: 8844056]  [MGI Ref ID J:34449]

Oostra BA; Willems PJ. 1995. A fragile gene. Bioessays 17(11):941-7. [PubMed: 8526888]  [MGI Ref ID J:41538]

Paradee W; Melikian HE; Rasmussen DL; Kenneson A; Conn PJ; Warren ST. 1999. Fragile X mouse: strain effects of knockout phenotype and evidence suggesting deficient amygdala function. Neuroscience 94(1):185-92. [PubMed: 10613508]  [MGI Ref ID J:59781]

Reyniers E; Van Bockstaele DR; De Boulle K; Kooy RF; Bakker CE; Oostra BA; Willems PJ. 1996. Mean corpuscular hemoglobin is not increased in Fmr1 knockout mice. Hum Genet 97(1):49-50. [PubMed: 8557260]  [MGI Ref ID J:31093]

Slegtenhorst-Eegdeman KE; de Rooij DG; Verhoef-Post M; van de Kant HJ; Bakker CE; Oostra BA; Grootegoed JA; Themmen AP. 1998. Macroorchidism in FMR1 knockout mice is caused by increased Sertoli cell proliferation during testicular development. Endocrinology 139(1):156-62. [PubMed: 9421410]  [MGI Ref ID J:44826]

Fmr1tm1Cgr related

Achuta VS; Rezov V; Uutela M; Louhivuori V; Louhivuori L; Castren ML. 2014. Tissue plasminogen activator contributes to alterations of neuronal migration and activity-dependent responses in fragile X mice. J Neurosci 34(5):1916-23. [PubMed: 24478370]  [MGI Ref ID J:206954]

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Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryThis strain is maintained by breeding homozygous females with hemizygous males. Fmr1 is an X linked gene.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2140.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2782.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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