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Strain Name:

B6CBACa Aw-J/A-Hydinhy3/J

Stock Number:

002703

Availability:

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General Terms and Conditions

Former Name      B6CBACa-Aw-J/A hy3/+    (Changed: 15-DEC-04 )
      B6CBACa-Aw-J/A-hy3/+    (Changed: 15-DEC-04 )
Genes & Alleles   Aw-J;   Hydin;   Hydinhy3;   a;


Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Strain
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Spontaneous Mutation
Specieslaboratory mouse
GenerationN2F2

Appearance
white-bellied agouti
Related Genotype: Aw-J/?

agouti
Related Genotype: A/A

Strain Description
Mice homozygous for the hydrocephalus 3 spontaneous mutation (Hydinhy3) are usually identifiable at 3 to 5 days. Those with frank hydrocephalus die by 4 or 5 weeks of age. The lateral ventricles and the third ventricle are enlarged, the aqueduct of Sylvius and the fourth ventricle are only slightly affected, and there is some dilatation of the ventral subarachnoid cistern. The hydrocephalus seems to be due to a defect in the subarachnoid space under the calvarium caused by an abnormal postnatal differentiation of the arachnoid mater and pia mater which prevents their separation. Penetrance is incomplete.

Strain Development
Hydrocephalus 3 (Hydinhy3) arose spontaneously in a heterogeneous stock of laboratory mice (Gruneberg, H.1943.). The mutation was received at The Jackson Laboratory by Dr. M.C. Green from Dr. Gruneberg in 1963. The strain was brother by sister bred by test matings and was at F76 in 1983. In 1995 the inbred strain stopped breeding and an outcross was made to B6CBACaF1 Aw/A. Tested males were then continuously backcrossed to the hybrid. In 1996 untyped +/? Females were bred with proven heterozygous males to generate embryos for cryopreservation.

Related Disease (OMIM) Terms

Hydrocephalus
Mammalian Phenotype Terms assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Hydinhy3/Hydinhy3

        involves: CBA
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:13035)
    • usually die before 2 months of age, generally around 4-6 week
  • craniofacial phenotype
  • abnormal skull morphology (MGI Ref ID J:5426)
    • thin skull
    • abnormal cranial suture morphology (MGI Ref ID J:5426)
      • open sutures
    • domed skull (MGI Ref ID J:13035)
      • develops after the first week of life
    • enlarged parietal bone (MGI Ref ID J:13103)
    • enlarged skull (MGI Ref ID J:13035)
      • skull volume doubled at birth, 0.88cc vs 0.44cc
      • does not develop before 3-5 days after birth or possible the 2nd week of life
  • nervous system phenotype
  • abnormal cerebral aqueduct (MGI Ref ID J:5377)
    • aqueduct of Sylvius occluded around 16 days of age
  • abnormal ependyma morphology (MGI Ref ID J:5426)
    • flattened cells in the ependymal lining
  • abnormal meninges (MGI Ref ID J:13103)
    • calvarium tends to adhere more tightly to brain
    • reduction of meningeal layers at 8 days of age
    • swelling of cells in meninges in the area of the foramina of Luschka and the otic capsules
  • abnormal telencephalon morphology (MGI Ref ID J:5377)
    • enlargement of extracellular spaces in the white matter after occlusion of the aqueduct of Sylvius
    • abnormal lateral ventricle morphology (MGI Ref ID J:13103)
      • foramina of Monro wider than normal
      • dilated lateral ventricles (MGI Ref ID J:13035)
        • enormously dilated at birth
        • thinning of pallium but basal ganglia less affected
        • not apparent before 3-5 days of age
    • thin cerebral cortex (MGI Ref ID J:5426)
      • cerebral cortex smooth and very thin
  • hydroencephaly (MGI Ref ID J:13035)
  • growth/size phenotype
  • cachexia (MGI Ref ID J:13035)
    • eventually loose weight
    • in an emaciated condition at the time of death
  • postnatal growth retardation (MGI Ref ID J:13035)
    • general growth retardation
    • never reach normal size
  • behavior/neurological phenotype
  • abnormal fear/anxiety-related behavior (MGI Ref ID J:5426)
    • "cowering" behavior observed at 21 days of age
  • aggression-related behavior (MGI Ref ID J:5426)
    • episodes of aggressive behavior
  • ataxia (MGI Ref ID J:5426)
  • hypoactivity (MGI Ref ID J:13035)
    • become inactive as they age
  • reproductive system phenotype
  • male infertility (MGI Ref ID J:13035)
    • probably (N=1)
  • muscle phenotype
  • muscle spasms (MGI Ref ID J:13103)
    • develop spasticity of the hind limbs
  • respiratory system phenotype
  • abnormal respiratory system physiology (MGI Ref ID J:13035)
    • nasal discharge composed of squamous epithelia and polymorphonuclear leukocytes
    • nasal discharge not seen in later studies
  • skeleton phenotype
  • abnormal skull morphology (MGI Ref ID J:5426)
    • thin skull
    • abnormal cranial suture morphology (MGI Ref ID J:5426)
      • open sutures
    • domed skull (MGI Ref ID J:13035)
      • develops after the first week of life
    • enlarged parietal bone (MGI Ref ID J:13103)
    • enlarged skull (MGI Ref ID J:13035)
      • skull volume doubled at birth, 0.88cc vs 0.44cc
      • does not develop before 3-5 days after birth or possible the 2nd week of life
  • kyphosis (MGI Ref ID J:5426)

Gene & Allele Details

Allele Symbol Aw-J
Allele Name white bellied agouti Jackson
Common Name(s) AWJ;
Strain of OriginC57BL/6J
Gene Symbol and Name a, nonagouti
Chromosome 2
Gene Common Name(s) AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor;
 
Allele Symbol Hydinhy3
Allele Name hydrocephalus 3
Common Name(s) hy-3;
Gene Symbol and Name Hydin, hydrocephalus inducing
Chromosome 8
Gene Common Name(s) 1700034M11Rik; 4930545D19Rik; AC069308.21, gene model 4; AC069308.21gm4; DKFZp434D0513; DKFZp434L0850; FLJ12871; FLJ14665; HYDIN1; KIAA1864; RIKEN cDNA 1700034M11 gene; RIKEN cDNA 4930545D19 gene; hy-3; hy3; hydrocephalus 3;
Molecular Note Matings between mice carrying a transgenic insertion allele in this gene and hy3 mice demonstrated that these two mutations fail to complement each other, and suggests that these two mutations are allelic and very likely result from disrupted function ofthe same gene or set of genes. [MGI Ref ID J:83437]

Control Information

  Control
   Untyped from the colony
 
  Considerations for Choosing Controls

Genotyping Protocols

Aw-J

Related Strains

View Strains carrying   Aw-J     (31 strains)

Strains carrying other alleles of a
003301   (C57BL/6J x C3H-Eya1bor)F1/J
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Pldnpa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
003879   B10;TFLe-a/a T tf/+ tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
002083   B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507   B6 x B6EiC3 a/A-Otcspf/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
000769   B6.C/(HZ18)By-at-44J/J
000001   B6.C3 A/a Mgrn1md/J
000203   B6.C3-Aiy/a/J
000017   B6.C3Fe-Avy/J
000628   B6.CE-A Amy1b Amy2b/J
005505   B6.Cg-Ay Slc7a11sut/LmLlp
000021   B6.Cg-Ay/J
001572   B6.Cg-am-J/J
004200   B6;CBACa Aw-J/A-Npr2cn-2J/J
000785   B6;D2-a Es1e/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
002807   B6C3Fe a/a-Meox2fla/J
000224   B6C3Fe a/a-Scyl1mdf/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
001815   B6C3Fe a/a-Col1a2oim/J
000231   B6C3Fe a/a-Csf1op/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000506   B6C3Fe a/a-Qkqk/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
001750   B6C3Fe a/a-XsJ/J
000624   B6C3Fe a/a-anx/J
003020   B6C3Fe a/a-dep/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000065   B6C3Fe a/a-we Pax1un at/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
001022   B6C3FeF1/J a/a
001752   B6CBCa Aw-J/A-T(7;15)9H/J
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
006450   B6EiC3 a/A-Vss/J
000557   B6EiC3-+ a/LnpUl A/J
000504   B6EiC3Sn a/A-Cacnb4lh/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001924   B6EiC3Sn a/A-Ts(1716)65Dn
001923   B6EiC3Sn a/A-Ts(417)2Lws Tim/J
000200   C3FeB6 A/Aw-J-Ankank/J
000638   C3FeB6 A/Aw-J-Spnb4qv-J/J
000225   C3FeLe.B6 a/a-Ptpn6me/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
001886   C3HeB/FeJLe a/a-gnd/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
002468   KK.Cg-Ay/J
000262   LS/LeJ
000283   LT.CAST-A/J
000265   MY/HuLeJ
000308   SSL/LeJ
001759   STOCK A Tyrc Sha/J
001427   STOCK Aw us/J
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Sisi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000281   STOCK a/a ma ft/ma ft/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying other alleles of a     (138 strains)

Research Applications

This mouse can be used to support research in many areas including:

Hydinhy3 related

Developmental Biology Research
Neurodevelopmental Defects

Neurobiology Research
Neurodevelopmental Defects

References

Additional References

Price and Supply Information

Strain Name: B6CBACa Aw-J/A-Hydinhy3/J
Stock Number: 002703
 

This strain is currently Contact Customer Service for more information..
To register your interest in this strain go to the Strain Interest Form.

Estimated Available for Sale Date:

Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.

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Supply Details

Standard SupplyContact Customer Service for more information.
Supply Notes This strain is included in the Mouse Mutant Resource collection.
Supply Notes Genomic DNA is available for this strain from the Mouse DNA Resource.
LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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