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General Terms and Conditions

Former Name	B6CBACa-Aw-J/A hy3/+    (Changed: 15-DEC-04 )
	B6CBACa-Aw-J/A-hy3/+    (Changed: 15-DEC-04 )
Genes & Alleles	Aw-J;   Hydin;   Hydinhy3;   a;

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Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Strain Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Spontaneous Mutation Species laboratory mouse Generation N2F2

Appearance
white-bellied agouti
Related Genotype: A^w-J/?

agouti
Related Genotype: A/A

Strain Description
Mice homozygous for the hydrocephalus 3 spontaneous mutation (Hydin^hy3) are usually identifiable at 3 to 5 days. Those with frank hydrocephalus die by 4 or 5 weeks of age. The lateral ventricles and the third ventricle are enlarged, the aqueduct of Sylvius and the fourth ventricle are only slightly affected, and there is some dilatation of the ventral subarachnoid cistern. The hydrocephalus seems to be due to a defect in the subarachnoid space under the calvarium caused by an abnormal postnatal differentiation of the arachnoid mater and pia mater which prevents their separation. Penetrance is incomplete.

Strain Development
Hydrocephalus 3 (Hydin^hy3) arose spontaneously in a heterogeneous stock of laboratory mice (Gruneberg, H.1943.). The mutation was received at The Jackson Laboratory by Dr. M.C. Green from Dr. Gruneberg in 1963. The strain was brother by sister bred by test matings and was at F76 in 1983. In 1995 the inbred strain stopped breeding and an outcross was made to B6CBACaF1 A^w/A. Tested males were then continuously backcrossed to the hybrid. In 1996 untyped +/? Females were bred with proven heterozygous males to generate embryos for cryopreservation.

Related Disease (OMIM) Terms Hydrocephalus

Mammalian Phenotype Terms assigned by genotype The following phenotype information may relate to a genetic background differing from this JAX® Mice strain. Hydinhy3/Hydinhy3         involves: CBA life span-post-weaning/aging premature death (MGI Ref ID J:13035) usually die before 2 months of age, generally around 4-6 week craniofacial phenotype abnormal skull morphology (MGI Ref ID J:5426) thin skull abnormal cranial suture morphology (MGI Ref ID J:5426) open sutures domed skull (MGI Ref ID J:13035) develops after the first week of life enlarged parietal bone (MGI Ref ID J:13103) enlarged skull (MGI Ref ID J:13035) skull volume doubled at birth, 0.88cc vs 0.44cc does not develop before 3-5 days after birth or possible the 2nd week of life nervous system phenotype abnormal cerebral aqueduct (MGI Ref ID J:5377) aqueduct of Sylvius occluded around 16 days of age abnormal ependyma morphology (MGI Ref ID J:5426) flattened cells in the ependymal lining abnormal meninges (MGI Ref ID J:13103) calvarium tends to adhere more tightly to brain reduction of meningeal layers at 8 days of age swelling of cells in meninges in the area of the foramina of Luschka and the otic capsules abnormal telencephalon morphology (MGI Ref ID J:5377) enlargement of extracellular spaces in the white matter after occlusion of the aqueduct of Sylvius abnormal lateral ventricle morphology (MGI Ref ID J:13103) foramina of Monro wider than normal dilated lateral ventricles (MGI Ref ID J:13035) enormously dilated at birth thinning of pallium but basal ganglia less affected not apparent before 3-5 days of age thin cerebral cortex (MGI Ref ID J:5426) cerebral cortex smooth and very thin hydroencephaly (MGI Ref ID J:13035) growth/size phenotype cachexia (MGI Ref ID J:13035) eventually loose weight in an emaciated condition at the time of death postnatal growth retardation (MGI Ref ID J:13035) general growth retardation never reach normal size behavior/neurological phenotype abnormal fear/anxiety-related behavior (MGI Ref ID J:5426) "cowering" behavior observed at 21 days of age aggression-related behavior (MGI Ref ID J:5426) episodes of aggressive behavior ataxia (MGI Ref ID J:5426) hypoactivity (MGI Ref ID J:13035) become inactive as they age reproductive system phenotype male infertility (MGI Ref ID J:13035) probably (N=1) muscle phenotype muscle spasms (MGI Ref ID J:13103) develop spasticity of the hind limbs respiratory system phenotype abnormal respiratory system physiology (MGI Ref ID J:13035) nasal discharge composed of squamous epithelia and polymorphonuclear leukocytes nasal discharge not seen in later studies skeleton phenotype abnormal skull morphology (MGI Ref ID J:5426) thin skull abnormal cranial suture morphology (MGI Ref ID J:5426) open sutures domed skull (MGI Ref ID J:13035) develops after the first week of life enlarged parietal bone (MGI Ref ID J:13103) enlarged skull (MGI Ref ID J:13035) skull volume doubled at birth, 0.88cc vs 0.44cc does not develop before 3-5 days after birth or possible the 2nd week of life kyphosis (MGI Ref ID J:5426)

Gene & Allele Details

Allele Symbol		Aw-J
Allele Name		white bellied agouti Jackson
Common Name(s)		AWJ;
Strain of Origin		C57BL/6J
Gene Symbol and Name		a, nonagouti
Chromosome		2
Gene Common Name(s)		AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor;
Allele Symbol		Hydinhy3
Allele Name		hydrocephalus 3
Common Name(s)		hy-3;
Gene Symbol and Name		Hydin, hydrocephalus inducing
Chromosome		8
Gene Common Name(s)		1700034M11Rik; 4930545D19Rik; AC069308.21, gene model 4; AC069308.21gm4; DKFZp434D0513; DKFZp434L0850; FLJ12871; FLJ14665; HYDIN1; KIAA1864; RIKEN cDNA 1700034M11 gene; RIKEN cDNA 4930545D19 gene; hy-3; hy3; hydrocephalus 3;
Molecular Note		Matings between mice carrying a transgenic insertion allele in this gene and hy3 mice demonstrated that these two mutations fail to complement each other, and suggests that these two mutations are allelic and very likely result from disrupted function ofthe same gene or set of genes. [MGI Ref ID J:83437]

Control Information

	Control
	Untyped from the colony
Considerations for Choosing Controls

Genotyping Protocols

A^w-J

Related Strains

Strains carrying   A^w-J allele

000202	AEJ/Gn-bd/J
000199	AEJ/GnLeJ
000593	B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J
000502	B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J
000599	B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J
002016	B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ
000552	B6-Aw-J-EdaTa-6J.Cg-Sxr
001730	B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J
000841	B6-Aw-J.CBy-EdaTa-By/J
001809	B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J
000600	B6-Gpi1b x B6CBCa Aw-J/A-T(7;15)9H Gpi1a/J
100409	B6129PF1/J-Aw-J/Aw
004200	B6;CBACa Aw-J/A-Npr2cn-2J/J
000505	B6C3 Aw-J/A-Mutedmu/J
000314	B6CBACa Aw-J/A-EdaTa/J-XO
000501	B6CBACa Aw-J/A-Aifm1Hq/J
001046	B6CBACa Aw-J/A-Grid2Lc/J
000500	B6CBACa Aw-J/A-Gs/J
000247	B6CBACa Aw-J/A-Kcnj6wv/J
000287	B6CBACa Aw-J/A-Plp1jp EdaTa/J
000515	B6CBACa Aw-J/A-SfnEr/J
000242	B6CBACa Aw-J/A-spc/J
000288	B6CBACa Aw-J/A-we a Mafbkr/J
001201	B6CBACaF1/J-Aw-J/A
001752	B6CBCa Aw-J/A-T(7;15)9H/J
000200	C3FeB6 A/Aw-J-Ankank/J
000638	C3FeB6 A/Aw-J-Spnb4qv-J/J
001203	C3FeB6F1/J A/Aw-J
000338	C57BL/6J Aw-J-EdaTa-6J/J
000569	C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
000051	C57BL/6J-Aw-J/J

View Strains carrying   A^w-J     (31 strains)

Strains carrying other alleles of a

003301	(C57BL/6J x C3H-Eya1bor)F1/J
000251	AEJ.Cg-ae +/a Gdf5bp-H/J
000202	AEJ/Gn-bd/J
000199	AEJ/GnLeJ
000427	B10.CE-H13b Aw/(30NX)SnJ
000420	B10.LP-H13b Aw/Sn
000477	B10.PA-Pldnpa H3e at/SnJ
000419	B10.UW-H3b we Pax1un at/SnJ
003879	B10;TFLe-a/a T tf/+ tf/J
001538	B6 x B6C3Sn a/A-T(1;9)27H/J
000916	B6 x B6C3Sn a/A-T(5;12)31H/J
000602	B6 x B6C3Sn a/A-T(8;16)17H/J
002083	B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507	B6 x B6EiC3 a/A-Otcspf/J
000618	B6 x FSB/GnEi a/a Ctslfs/J
000577	B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601	B6 x STOCK a/a T(7;18)50H/J
000592	B6 x STOCK T(2;4)13H a/J
000769	B6.C/(HZ18)By-at-44J/J
000001	B6.C3 A/a Mgrn1md/J
000203	B6.C3-Aiy/a/J
000017	B6.C3Fe-Avy/J
000628	B6.CE-A Amy1b Amy2b/J
005505	B6.Cg-Ay Slc7a11sut/LmLlp
000021	B6.Cg-Ay/J
001572	B6.Cg-am-J/J
004200	B6;CBACa Aw-J/A-Npr2cn-2J/J
000785	B6;D2-a Es1e/J
000604	B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
002807	B6C3Fe a/a-Meox2fla/J
000224	B6C3Fe a/a-Scyl1mdf/J
001037	B6C3Fe a/a-Agtpbp1pcd/J
000221	B6C3Fe a/a-Alx4lst-J/J
002062	B6C3Fe a/a-Atp7aMo-8J/J
001756	B6C3Fe a/a-Cacng2stg/J
001815	B6C3Fe a/a-Col1a2oim/J
000231	B6C3Fe a/a-Csf1op/J
000209	B6C3Fe a/a-Dh/J
000211	B6C3Fe a/a-Dstdt-J/J
000210	B6C3Fe a/a-Edardl-J/J
000207	B6C3Fe a/a-Edaraddcr/J
000182	B6C3Fe a/a-Eef1a2wst/J
001278	B6C3Fe a/a-Glra1spd/J
000241	B6C3Fe a/a-Glrbspa/J
002875	B6C3Fe a/a-Hoxd13spdh/J
000304	B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226	B6C3Fe a/a-Largemyd/J
000636	B6C3Fe a/a-Lmx1adr-J/J
001280	B6C3Fe a/a-Lse/J
001573	B6C3Fe a/a-MitfMi/J
001035	B6C3Fe a/a-Napahyh/J
000181	B6C3Fe a/a-Otogtwt/J
000278	B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205	B6C3Fe a/a-Papss2bm/J
002078	B6C3Fe a/a-Pcdh15av-2J/J
000246	B6C3Fe a/a-Pitpnavb/J
001430	B6C3Fe a/a-Ptch1mes/J
000506	B6C3Fe a/a-Qkqk/J
000235	B6C3Fe a/a-Relnrl/J
000237	B6C3Fe a/a-Rorasg/J
000290	B6C3Fe a/a-Sox10Dom/J
000230	B6C3Fe a/a-Tcirg1oc/J
003612	B6C3Fe a/a-Trak1hyrt/J
001512	B6C3Fe a/a-Ttnmdm/J
001607	B6C3Fe a/a-Unc5crcm/J
000005	B6C3Fe a/a-Wc/J
000243	B6C3Fe a/a-Wnt1sw/J
000248	B6C3Fe a/a-Xpl/J
001750	B6C3Fe a/a-XsJ/J
000624	B6C3Fe a/a-anx/J
003020	B6C3Fe a/a-dep/J
002018	B6C3Fe a/a-din/J
002339	B6C3Fe a/a-nma/J
000240	B6C3Fe a/a-soc/J
000063	B6C3Fe a/a-sy/J
001055	B6C3Fe a/a-tip/J
000245	B6C3Fe a/a-tn/J
000065	B6C3Fe a/a-we Pax1un at/J
000296	B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019	B6C3Fe-a/a-Itpr1opt/J
001022	B6C3FeF1/J a/a
001752	B6CBCa Aw-J/A-T(7;15)9H/J
000971	B6EiC3 a/A-Och/J
000551	B6EiC3 a/A-Tbx15de-H/J
006450	B6EiC3 a/A-Vss/J
000557	B6EiC3-+ a/LnpUl A/J
000504	B6EiC3Sn a/A-Cacnb4lh/J
000553	B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
000503	B6EiC3Sn a/A-Gy/J
001811	B6EiC3Sn a/A-Otcspf-ash/J
002343	B6EiC3Sn a/A-Otcspf/J
000391	B6EiC3Sn a/A-Pax6Sey-Dey/J
001924	B6EiC3Sn a/A-Ts(1716)65Dn
001923	B6EiC3Sn a/A-Ts(417)2Lws Tim/J
000200	C3FeB6 A/Aw-J-Ankank/J
000638	C3FeB6 A/Aw-J-Spnb4qv-J/J
000225	C3FeLe.B6 a/a-Ptpn6me/J
000198	C3FeLe.B6-a/J
000291	C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001272	C3H/HeSnJ-Ahvy/J
000099	C3HeB/FeJ-Avy/J
001886	C3HeB/FeJLe a/a-gnd/J
000584	C57BL/6J-+ T(1;2)5Ca/a +/J
000258	C57BL/6J-Ai/a/J
000774	C57BL/6J-Asy/a/J
000055	C57BL/6J-at-33J/J
000070	C57BL/6J-atd/J
000284	CWD/LeJ
000670	DBA/1J
000671	DBA/2J
001057	HPT/LeJ
000260	JGBF/LeJ
002468	KK.Cg-Ay/J
000262	LS/LeJ
000283	LT.CAST-A/J
000265	MY/HuLeJ
000308	SSL/LeJ
001759	STOCK A Tyrc Sha/J
001427	STOCK Aw us/J
000994	STOCK a Myo5ad Mregdsu/J
000064	STOCK a Tyrp1b Sisi/J
002238	STOCK a Tyrp1b shmy/J
001433	STOCK a skt/J
000579	STOCK a tp/J
000319	STOCK a us/J
002648	STOCK a/a Cln6nclf/J
000317	STOCK a/a Egfrwa2/J
000302	STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286	STOCK a/a Myo5ad fd/+ +/J
000206	STOCK a/a Tyrc-h/J
001432	STOCK a/a Tyrp1b sks/Tyrp1b +/J
000281	STOCK a/a ma ft/ma ft/J
000312	STOCK stb + a/+ Fignfi a/J
000596	STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970	STOCK T(2;16)28H A/T(2;16)28H a/J
000590	STOCK T(2;4)1Sn a/J
000594	STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623	TR/DiEiJ

View Strains carrying other alleles of a     (138 strains)

Research Applications

This mouse can be used to support research in many areas including:

Hydin^hy3 related

Developmental Biology Research
Neurodevelopmental Defects

Neurobiology Research
Neurodevelopmental Defects

References

Additional References

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Price and Supply Information

Strain Name:	B6CBACa Aw-J/A-Hydinhy3/J
Stock Number:	002703

 

This strain is currently Contact Customer Service for more information..
To register your interest in this strain go to the Strain Interest Form.

Estimated Available for Sale Date:

Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.

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Supply Details

Standard Supply	Contact Customer Service for more information.
Supply Notes	This strain is included in the Mouse Mutant Resource collection.
Supply Notes	Genomic DNA is available for this strain from the Mouse DNA Resource.
Licensing	See General Terms and Conditions below
Control Information	View Control Information in Strain Details.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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