Strain Name:

B6;129S-Oxttm1Wsy/J

Stock Number:

002713

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
 
Donating InvestigatorDr. W. Scott Young III,   National Institute of Mental Health

Description
Mice homozygous for the Oxttm1Wsy targeted mutation are viable and fertile. Females are able to successfully mate, deliver and produce milk however milk injection is impaired. Pups do not successfully suckle and must be fostered to survive. Oxytocin injection restores milk injection in response to suckling. Homozygotes displayed reduced aggressive behavior relative to heterozygotes and wild-type mice.

Development
This strain was developed in the laboratory of Dr. W. Scott Young at the National Institute of Mental Health. Exons 2 and 3 of the oxytocin gene were replaced with a vector containing the neomycin resistance gene.

Control Information

  Control
   Wild-type from the colony
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Oxt
024234   B6;129S-Oxttm1.1(cre)Dolsn/J
006043   B6;SJL-Tg(Oxt/EGFP)AI03Wsy/J
View Strains carrying other alleles of Oxt     (2 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Oxttm1Wsy/Oxt+

        involves: 129S/SvEv * C57BL/6
  • behavior/neurological phenotype
  • *normal* behavior/neurological phenotype
    • heterozygotes exhibit neither significant differences in aggressiveness and exploratory activity nor sensorimotor deficits in olfaction, visual acuity, coordination or forearm strength tasks   (MGI Ref ID J:41146)
  • digestive/alimentary phenotype
  • abnormal defecation
    • heterozygotes display a significantly reduced frequency of defecation relative to wild-type mice   (MGI Ref ID J:41146)

Oxttm1Wsy/Oxttm1Wsy

        involves: 129S/SvEv * C57BL/6
  • endocrine/exocrine gland phenotype
  • abnormal lactation   (MGI Ref ID J:36926)
    • abnormal milk ejection   (MGI Ref ID J:91657)
      • homozygous mice are grossly normal and fertile, carry normal-sized litters and produce milk, but fail to eject milk in response to suckling   (MGI Ref ID J:36926)
      • as a result, newborn pups fail to survive for >24 hrs, dying without milk in their stomachs, despite apparently normal suckling   (MGI Ref ID J:36926)
      • i.p. injection of oxytocin into homozygous mutant dams restores milk ejection in response to suckling   (MGI Ref ID J:36926)
  • abnormal mammary gland growth during lactation
    • at parturition, homozygous dams show normal alveolar density and mammary epithelial cell differentiation   (MGI Ref ID J:91657)
    • however, shortly after parturition, homozygous dams display partially involuted mammary tissue, despite suckling and the presence of systemic lactogenic hormones   (MGI Ref ID J:91657)
    • in addition, homozygous dams fail to exhibit post-partum DNA synthesis and proliferation of alveolar cells   (MGI Ref ID J:91657)
  • renal/urinary system phenotype
  • *normal* renal/urinary system phenotype   (MGI Ref ID J:91657)
    • male homozygotes exhibit normal plasma osmolarities and are able to concentrate their urine after 24 hrs of water deprevation male homozygotes exhibit normal plasma osmolarities and are able to concentrate their urine after 24 hrs of water deprovation   (MGI Ref ID J:36926)
  • behavior/neurological phenotype
  • abnormal circadian rhythm
    • under baseline conditions, homozygous males display an abnormal circadian rhythm of salt and water intake   (MGI Ref ID J:72051)
  • abnormal drinking behavior
    • under baseline conditions, homozygous males show no significant differences in water consumption relative to wild-type mice   (MGI Ref ID J:72051)
    • however, mutant males initiate water intake 3 hrs earlier in the light/dark cycle relative to wild-type males   (MGI Ref ID J:72051)
  • abnormal food preference
    • under baseline conditions, homozygous males exhibit a 4-6-fold increase in salt licking activity (licks/24 hrs) and salt (2% NaCl) consumption relative to wild-type males   (MGI Ref ID J:72051)
    • salt licking activity is prominent during the dark period, as expected   (MGI Ref ID J:72051)
    • voluntary consumption of a hypertonic salt solution is not driven by plasma hyperosmolarity, as no changes in ionic concentrations are observed   (MGI Ref ID J:72051)
    • despite increased 2% NaCl consumption, homozygotes are able to maintain a balance of intake and excretion   (MGI Ref ID J:72051)
  • abnormal milk ejection   (MGI Ref ID J:91657)
    • homozygous mice are grossly normal and fertile, carry normal-sized litters and produce milk, but fail to eject milk in response to suckling   (MGI Ref ID J:36926)
    • as a result, newborn pups fail to survive for >24 hrs, dying without milk in their stomachs, despite apparently normal suckling   (MGI Ref ID J:36926)
    • i.p. injection of oxytocin into homozygous mutant dams restores milk ejection in response to suckling   (MGI Ref ID J:36926)
  • decreased aggression   (MGI Ref ID J:91657)
    • homozygotes display reduced aggression in agonistic bouts within a neutral arena, with significantly less time spent in aggressive encounters and significantly shorter aggressive attacks   (MGI Ref ID J:41146)
    • notably, homozygotes exhibit a greater reduction in agonistic interactions in the neutral arena than in the resident-intruder paradigm   (MGI Ref ID J:41146)
  • decreased grooming behavior
    • homozygotes exhibit neither significant differences in exploratory activity in the open field test nor sensorimotor deficits in olfaction, visual acuity, coordination or forearm strength tasks   (MGI Ref ID J:41146)
    • however, homozygotes spend significantly less time autogrooming in the open field than wild-type mice   (MGI Ref ID J:41146)
  • cardiovascular system phenotype
  • abnormal cardiovascular system physiology
    • in response to depressor challenges, homozygotes show a significant reduction in maximal bradycardia and a potentiation of reflex tachycardia, in accordance with an increased sympathetic reserve to the heart   (MGI Ref ID J:83910)
    • after beta 1-adrenergic and cholinergic blockade, homozygotes show a normal magnitude of sympathetic and vagal tone to the heart and periphery; however, mutants exhibit an upward shift of sympathetic tone to higher heart rate values resulting in larger responses to cholinergic blockade   (MGI Ref ID J:83910)
    • hypotension
      • homozygotes exhibit a mild but consistent hypotension (102 ? 3 vs. 110 ? 3 mmHg), with no significant changes in baseline heart rate relative to wild-type mice   (MGI Ref ID J:83910)
  • nervous system phenotype
  • abnormal baroreceptor physiology
    • homozygotes exhibit a >3-fold increase in the gain of reflex as well as a notable decrease in the operating pressure range of baroreceptor reflex function   (MGI Ref ID J:83910)
  • integument phenotype
  • abnormal lactation   (MGI Ref ID J:36926)
    • abnormal milk ejection   (MGI Ref ID J:91657)
      • homozygous mice are grossly normal and fertile, carry normal-sized litters and produce milk, but fail to eject milk in response to suckling   (MGI Ref ID J:36926)
      • as a result, newborn pups fail to survive for >24 hrs, dying without milk in their stomachs, despite apparently normal suckling   (MGI Ref ID J:36926)
      • i.p. injection of oxytocin into homozygous mutant dams restores milk ejection in response to suckling   (MGI Ref ID J:36926)
  • abnormal mammary gland growth during lactation
    • at parturition, homozygous dams show normal alveolar density and mammary epithelial cell differentiation   (MGI Ref ID J:91657)
    • however, shortly after parturition, homozygous dams display partially involuted mammary tissue, despite suckling and the presence of systemic lactogenic hormones   (MGI Ref ID J:91657)
    • in addition, homozygous dams fail to exhibit post-partum DNA synthesis and proliferation of alveolar cells   (MGI Ref ID J:91657)

Oxttm1Wsy/Oxttm1Wsy

        B6;129S-Oxttm1Wsy/J
  • behavior/neurological phenotype
  • abnormal anxiety-related response
    • at 6-11 months, homozygous females (from F5 and F6) display increased anxiety-like behavior in the elevated plus-maze (EPM), despite a normal overall locomotor activity   (MGI Ref ID J:83709)
    • in females, enhanced anxiety is reversed by icv administration of exogenous oxytocin; furthermore, central infusion of an oxytocin receptor antagonist prior to the administration of synthetic oxytocin blocks the anxiolytic effect   (MGI Ref ID J:83709)
    • in contrast, age-matched homozygous males exhibit reduced anxiety-like behavior in the EPM relative to wild-type males   (MGI Ref ID J:83709)
  • decreased compensatory feeding amount
    • after an 18-h fast, homozygous males consume slightly - but not significantly - less chow during a 60-min refeeding period when dehydrated compared with their intake when reuhydrated   (MGI Ref ID J:98510)
    • in mutants, attenuated dehydration anorexia is accompanied by reduced Fos expression in the hindbrain dorsal vagal complex   (MGI Ref ID J:98510)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Oxttm1Wsy related

Cancer Research
Genes Regulating Growth and Proliferation

Endocrine Deficiency Research
Hypothalamus/Pituitary Defects
Mammary Gland Defects

Neurobiology Research
Behavioral and Learning Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Oxttm1Wsy
Allele Name targeted mutation 1, W Scott Young III
Allele Type Targeted (knock-out)
Common Name(s) OT-; OTKO -;
Mutation Made ByDr. W. Scott Young III,   National Institute of Mental Health
Strain of Origin129S/SvEv-Gpi1
ES Cell Line NameCCE/EK.CCE
ES Cell Line Strain129S/SvEv-Gpi1
Gene Symbol and Name Oxt, oxytocin
Chromosome 2
Gene Common Name(s) OT; OT-NPI; OXT-NPI; Oxy;
Molecular Note The gene was disrupted using neomycin resistance cassette. The vector replaced sequences encoding the last two exons. Hybridization histochemistry and immunocytochemistry were used to demonstrate the lack of transcript and protein in homozygous mutant animals. [MGI Ref ID J:36926]

Genotyping

Genotyping Information

Genotyping Protocols

Oxttm1Wsy, Melt Curve Analysis
Oxttm1Wsy, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Young WS 3rd; Shepard E; Amico J; Hennighausen L; Wagner KU; LaMarca ME; McKinney C; Ginns EI. 1996. Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition. J Neuroendocrinol 8(11):847-53. [PubMed: 8933362]  [MGI Ref ID J:36926]

Additional References

Amico JA; Morris M; Vollmer RR. 2001. Mice deficient in oxytocin manifest increased saline consumption following overnight fluid deprivation. Am J Physiol Regul Integr Comp Physiol 281(5):R1368-73. [PubMed: 11641104]  [MGI Ref ID J:72554]

DeVries AC; Young WS 3rd; Nelson RJ. 1997. Reduced aggressive behaviour in mice with targeted disruption of the oxytocin gene. J Neuroendocrinol 9(5):363-8. [PubMed: 9181490]  [MGI Ref ID J:41146]

Mantella RC; Vollmer RR; Li X; Amico JA. 2003. Female oxytocin-deficient mice display enhanced anxiety-related behavior. Endocrinology 144(6):2291-6. [PubMed: 12746288]  [MGI Ref ID J:83709]

Michelini LC; Marcelo MC; Amico J; Morris M. 2003. Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice. Am J Physiol Heart Circ Physiol 284(6):H2269-76. [PubMed: 12531722]  [MGI Ref ID J:83910]

Puryear R; Rigatto KV; Amico JA; Morris M. 2001. Enhanced salt intake in oxytocin deficient mice. Exp Neurol 171(2):323-8. [PubMed: 11573985]  [MGI Ref ID J:72051]

Oxttm1Wsy related

Amico JA; Cai HM; Vollmer RR. 2008. Corticosterone release in oxytocin gene deletion mice following exposure to psychogenic versus non-psychogenic stress. Neurosci Lett 442(3):262-6. [PubMed: 18625285]  [MGI Ref ID J:140241]

Amico JA; Morris M; Vollmer RR. 2001. Mice deficient in oxytocin manifest increased saline consumption following overnight fluid deprivation. Am J Physiol Regul Integr Comp Physiol 281(5):R1368-73. [PubMed: 11641104]  [MGI Ref ID J:72554]

Amico JA; Vollmer RR; Cai HM; Miedlar JA; Rinaman L. 2005. Enhanced initial and sustained intake of sucrose solution in mice with an oxytocin gene deletion. Am J Physiol Regul Integr Comp Physiol 289(6):R1798-806. [PubMed: 16150836]  [MGI Ref ID J:102577]

Assinder SJ; Rezvani A; Nicholson HD. 2002. Oxytocin promotes spermiation and sperm transfer in the mouse. Int J Androl 25(1):19-27. [PubMed: 11869373]  [MGI Ref ID J:103024]

Becker RO; Lazzari VM; Menezes IC; Morris M; Rigatto K; Lucion AB; Rasia-Filho AA; Giovenardi M. 2013. Sexual behavior and dendritic spine density of posterodorsal medial amygdala neurons in oxytocin knockout female mice. Behav Brain Res 256:95-100. [PubMed: 23906766]  [MGI Ref ID J:202101]

Bernatova I; Rigatto KV; Key MP; Morris M. 2004. Stress-induced pressor and corticosterone responses in oxytocin-deficient mice. Exp Physiol 89(5):549-57. [PubMed: 15184356]  [MGI Ref ID J:105540]

Billings LB; Spero JA; Vollmer RR; Amico JA. 2006. Oxytocin null mice ingest enhanced amounts of sweet solutions during light and dark cycles and during repeated shaker stress. Behav Brain Res 171(1):134-41. [PubMed: 16677726]  [MGI Ref ID J:108978]

Crawley JN; Chen T; Puri A; Washburn R; Sullivan TL; Hill JM; Young NB; Nadler JJ; Moy SS; Young LJ; Caldwell HK; Young WS. 2007. Social approach behaviors in oxytocin knockout mice: comparison of two independent lines tested in different laboratory environments. Neuropeptides 41(3):145-63. [PubMed: 17420046]  [MGI Ref ID J:124563]

DeVries AC; Young WS 3rd; Nelson RJ. 1997. Reduced aggressive behaviour in mice with targeted disruption of the oxytocin gene. J Neuroendocrinol 9(5):363-8. [PubMed: 9181490]  [MGI Ref ID J:41146]

Lazzari VM; Becker RO; de Azevedo MS; Morris M; Rigatto K; Almeida S; Lucion AB; Giovenardi M. 2013. Oxytocin modulates social interaction but is not essential for sexual behavior in male mice. Behav Brain Res 244:130-6. [PubMed: 23376700]  [MGI Ref ID J:197468]

Macbeth AH; Lee HJ; Edds J; Young WS 3rd. 2009. Oxytocin and the oxytocin receptor underlie intrastrain, but not interstrain, social recognition. Genes Brain Behav 8(5):558-67. [PubMed: 19531157]  [MGI Ref ID J:151090]

Mantella RC; Vollmer RR; Amico JA. 2005. Corticosterone release is heightened in food or water deprived oxytocin deficient male mice. Brain Res 1058(1-2):56-61. [PubMed: 16168966]  [MGI Ref ID J:101830]

Mantella RC; Vollmer RR; Li X; Amico JA. 2003. Female oxytocin-deficient mice display enhanced anxiety-related behavior. Endocrinology 144(6):2291-6. [PubMed: 12746288]  [MGI Ref ID J:83709]

Michelini LC; Marcelo MC; Amico J; Morris M. 2003. Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice. Am J Physiol Heart Circ Physiol 284(6):H2269-76. [PubMed: 12531722]  [MGI Ref ID J:83910]

Miedlar JA; Rinaman L; Vollmer RR; Amico JA. 2007. Oxytocin gene deletion mice overconsume palatable sucrose solution but not palatable lipid emulsions. Am J Physiol Regul Integr Comp Physiol 293(3):R1063-8. [PubMed: 17596329]  [MGI Ref ID J:124698]

Pedersen CA; Vadlamudi SV; Boccia ML; Amico JA. 2006. Maternal behavior deficits in nulliparous oxytocin knockout mice. Genes Brain Behav 5(3):274-81. [PubMed: 16594980]  [MGI Ref ID J:122235]

Puryear R; Rigatto KV; Amico JA; Morris M. 2001. Enhanced salt intake in oxytocin deficient mice. Exp Neurol 171(2):323-8. [PubMed: 11573985]  [MGI Ref ID J:72051]

Rigatto K; Puryear R; Bernatova I; Morris M. 2003. Salt appetite and the renin-angiotensin system: effect of oxytocin deficiency. Hypertension 42(4):793-7. [PubMed: 12953013]  [MGI Ref ID J:103065]

Rinaman L; Vollmer RR; Karam J; Phillips D; Li X; Amico JA. 2005. Dehydration anorexia is attenuated in oxytocin-deficient mice. Am J Physiol Regul Integr Comp Physiol 288(6):R1791-9. [PubMed: 15718385]  [MGI Ref ID J:98510]

Sclafani A; Rinaman L; Vollmer RR; Amico JA. 2007. Oxytocin knockout mice demonstrate enhanced intake of sweet and nonsweet carbohydrate solutions. Am J Physiol Regul Integr Comp Physiol 292(5):R1828-33. [PubMed: 17272659]  [MGI Ref ID J:121469]

Vollmer RR; Li X; Karam JR; Amico JA. 2006. Sodium ingestion in oxytocin knockout mice. Exp Neurol 202(2):441-8. [PubMed: 16930592]  [MGI Ref ID J:144672]

Wersinger SR; Temple JL; Caldwell HK; Young WS 3rd. 2008. Inactivation of the oxytocin and the vasopressin (Avp) 1b receptor genes, but not the Avp 1a receptor gene, differentially impairs the Bruce effect in laboratory mice (Mus musculus). Endocrinology 149(1):116-21. [PubMed: 17947352]  [MGI Ref ID J:141469]

Wintermantel TM; Mayer AK; Schutz G; Greiner EF. 2002. Targeting mammary epithelial cells using a bacterial artificial chromosome. Genesis 33(3):125-30. [PubMed: 12124945]  [MGI Ref ID J:95736]

Young WS 3rd; Shepard E; DeVries AC; Zimmer A; LaMarca ME; Ginns EI; Amico J; Nelson RJ; Hennighausen L; Wagner KU. 1998. Targeted reduction of oxytocin expression provides insights into its physiological roles. Adv Exp Med Biol 449:231-40. [PubMed: 10026810]  [MGI Ref ID J:91657]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryThis strain is maintained by heterozygous sibling matings. Expected coat color from breeding:Black,White Bellied Agouti

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2450.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Embryos

Price (US dollars $)
Frozen Embryo $1600.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3185.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Embryos

Price (US dollars $)
Frozen Embryo $2080.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Wild-type from the colony
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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