Description

Strain Information

Former Names STOCK hop/J    (Changed: 15-DEC-04 ) Type Congenic; Mutant Stock; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain BALB/cByJ Donor Strain undefined mixed background Generation N17 (12-NOV-10) Generation Definitions

Appearance
albino, ataxic
Related Genotype: Tyrp1^b/Tyrp1^b Tyr^c/Tyr^c hop/hop

albino, unaffected
Related Genotype: Tyrp1^b/Tyrp1^b Tyr^c/Tyr^c +/? or Tyrp1^b/Tyrp1^b Tyr^c/Tyr^c hop/+

Description
Mice homozygous for the hop-sterile spontaneous mutation (hop) are viable, females are fertile but males are sterile. Homozygous mutant mice walk with a characteristic hopping gait using the hindlegs simultaneously. There is preaxial polydactyly of both fore- and hindfeet. Defects in spermatogenesis result in abnormal sperm tail development. Tailed sperm are completely absent from the lumen of the testicular tubules. The second meiotic division is frequently abnormal or incomplete, often leaving four centrioles per cell. These centrioles usually fail to form flagella, and tail development is arrested.

Development
The hop-sterile (hop) mutation arose spontaneously in an unirradiated stock at the MRC Radiobiology Unit at Harwell in 1967. In 1996 this strain was imported to The Jackson Laboratory from Dr. Mary Ann Handel. At that time this mutation was not on a defined genetic background and the heterozygous offspring from the first backcross of this mixed background to BALB/c were received. These were intercrossed and the mutation has been maintained via backcross-intercross to BALB/cByJ ever since. In 1998 the strain reached N3, before the end of 1999 it reached N5, and by 2003 it had been backcrossed 11 times to BALB/cByJ.

Control Information

	Control
	+/? untyped from the colony
	Heterozygote from the colony
Considerations for Choosing Controls

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

hop/hop

        Background Not Specified

• behavior/neurological phenotype
• abnormal gait
  • homozygotes display a hopping gait in which the hind legs are move simultaneously   (MGI Ref ID J:5206)
• abnormal posture
  • unlike in wild-type mice the legs in homozygous mice are not widely spread   (MGI Ref ID J:5206)
• impaired swimming
  • the hindquaters are twisted and sinuous tail motions are absent when homozygotes swim   (MGI Ref ID J:5206)
• endocrine/exocrine gland phenotype
• small testis
  • adult testes are smaller in mutants compared to wild-type littermates   (MGI Ref ID J:5206)
• reproductive system phenotype
• abnormal male meiosis
  • second meiotic division is often abnormal or incomplete with four centrioles per cell   (MGI Ref ID J:5206)
  • these centrioles usually fail to form flagella   (MGI Ref ID J:5206)
• abnormal sperm flagellum morphology
  • sperm tails are either absent or highly abnormal   (MGI Ref ID J:5206)
• • absent sperm flagellum   (MGI Ref ID J:5206)
• abnormal spermatid morphology
  • spermatids with abnormal heads and tails are seen in homozygotes   (MGI Ref ID J:5206)
• • abnormal manchette morphology
    • microtubules of the manchette overproliferate and impinge on nuclear integrity in homozygotes   (MGI Ref ID J:89468)
• abnormal spermiogenesis
  • cytokinesis is frequently interrupted at an early stage resulting in binucleated cells   (MGI Ref ID J:5206)
  • spermatids with abnormal heads and tails are seen in homozygotes   (MGI Ref ID J:5206)
  • microtubules of the manchette overproliferate and impinge on nuclear integrity in homozygotes   (MGI Ref ID J:89468)
• azoospermia
  • no tailed sperm are found in the seminiferous tubules   (MGI Ref ID J:5206)
  • a few elongated spermatids with abnormal flagella but no mature sperm are found in the seminiferous tubules of homozygotes   (MGI Ref ID J:89468)
• male infertility   (MGI Ref ID J:89468)
  • males are completely sterile   (MGI Ref ID J:5206)
• small testis
  • adult testes are smaller in mutants compared to wild-type littermates   (MGI Ref ID J:5206)
• limbs/digits/tail phenotype
• polydactyly
  • preaxial polydactyly of both hind- and forefeet   (MGI Ref ID J:5206)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

hop related

Developmental Biology Research
Skeletal Defects
      polydactyly

Neurobiology Research
Ataxia (Movement) Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads
      males only
Fertility Defects
      males only

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		hop
Allele Name		hop sterile
Allele Type		Spontaneous
Gene Symbol and Name		hop, hop-sterile
Chromosome		6
Gene Common Name(s)		hpy; hydrocephalic-polydactyl;
Molecular Note		The spontaneous mutation hop-sterile arose in an unirradiated stock at the MRC Radiobiology Unit at Harwell in 1967.

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Johnson DR; Hunt DM. 1971. Hop-sterile, a mutant gene affecting sperm tail development in the mouse. J Embryol Exp Morphol 25(2):223-36. [PubMed: 5088020]  [MGI Ref ID J:5206]

Additional References

Schumacher JM; Artzt K; Braun RE. 1998. Spermatid perinuclear ribonucleic acid-binding protein binds microtubules in vitro and associates with abnormal manchettes in vivo in mice. Biol Reprod 59(1):69-76. [PubMed: 9674995]  [MGI Ref ID J:89468]

hop related

Schumacher JM; Artzt K; Braun RE. 1998. Spermatid perinuclear ribonucleic acid-binding protein binds microtubules in vitro and associates with abnormal manchettes in vivo in mice. Biol Reprod 59(1):69-76. [PubMed: 9674995]  [MGI Ref ID J:89468]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Purchasing information

Pricing, Supply Level & Notes, Controls

General Supply Notes

• This strain is included in the Mouse Mutant Resource collection.
• Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	+/? untyped from the colony
	Heterozygote from the colony
Considerations for Choosing Controls
Control Pricing Information for Genetically Engineered Mutant Strains.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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