Strain Name: |
B6.CAST-Cdh23Ahl+/Kjn |
|---|---|
Stock Number: |
002756 |
Availability: | Repository- Live |
General Terms and Conditions |
| Former Name |
B6.CAST-Ahl+ (Changed: 15-DEC-04
) |
|
B6.CAST-Cdh23CAST/J (Changed: 15-DEC-04
) | |
|
B6.CAST-Cdh23ahl/J (Changed: 15-DEC-04
) | |
| Genes & Alleles | Cdh23; Cdh23Ahl+; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Mating System Homozygote x Homozygote (Female x Male) Species laboratory mouse and M. m. castaneus Generation N10F19 (06-DEC-07) Appearance
black
Related Genotype: a/aStrain Description
C57BL/6 mice develop severe and progressive late-onset hearing loss. Histopathological changes associated with age-related hearing loss includes the disruption of both outer and inner hair cells. C57BL/6 mice are also more susceptible to noise-induced hearing loss. Age related hearing loss 1 (Ahl), a major gene responsible for this hearing loss, was mapped in an intersubspecific backcross by measuring elevated auditory-evoked brainstem response (ABR) thresholds. Ahl is located on Chromosome 10 near marker D10Mit5. B6.CAST- +Ahl is a congenic strain that carries the wildtype allele of Ahl producing C57BL/6 mice that are not susceptible to age related hearing loss.
Gene & Allele Details
| Allele Symbol | Cdh23Ahl+ | ||
|---|---|---|---|
| Allele Name | CAST/Ei | ||
| Common Name(s) | Cdh23753G; Cdh23CAST; Cdh23mdfw-ahl-CAST/Ei; | ||
| Strain of Origin | CAST/EiJ | ||
| Gene Symbol and Name | Cdh23, cadherin 23 (otocadherin) | ||
| Chromosome | 10 | ||
| Gene Common Name(s) | 4930542A03Rik; DFNB12; DKFZp434P2350; FLJ00233; FLJ36499; KIAA1774; KIAA1812; MGC102761; RIKEN cDNA 4930542A03 gene; USH1D; W; age related hearing loss 1; ahl; bob; bobby; bus; bustling; mdfw; modifier of deaf waddler; neuroscience mutagenesis facility, 112; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; nmf112; nmf181; nmf252; v; waltzer; | ||
| Molecular Note | This allele contrasts with the allele found in C57BL/6J in that a G is present at nucleotide position 753 rather than an A. [J:86905] | ||
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Cdh23
001137 129P1/ReJ 000690 129P3/J 002065 129T2/SvEmsJ 000691 129X1/SvJ 000646 A/J 000647 A/WySnJ 003070 ALR/LtJ 003072 ALS/LtJ 004502 B6;AKR-Lxl2/J 002432 B6J x B6.C-H2bm1/ByJ-Cdh23v-J/J 001026 BALB/cByJ 000653 BUB/BnJ 005494 C3.129S1(B6)-Grm1rcw/J 000664 C57BL/6J 002552 C57BL/6J-Cdh23v-2J/J 004764 C57BL/6J-Cdh23v-8J/J 004819 C57BL/6J-Cdh23v-9J/J 003129 C57BL/6J-Epha4rb-2J/J 004820 C57BL/6J-Kcne12J/J 004703 C57BL/6J-Nmf134/J 004811 C57BL/6J-nmf110/J 004812 C57BL/6J-nmf111/J 004747 C57BL/6J-nmf118/J 004656 C57BL/6J-nmf88/J 004391 C57BL/6J-Chr 13A/J/NaJ 004385 C57BL/6J-Chr 7A/J/NaJ 000662 C57BLKS/J 000667 C57BR/cdJ 000668 C57L/J 000669 C58/J 005016 CByJ;B6-Cdh23v-10J/J 000657 CE/J 000670 DBA/1J 001140 DBA/1LacJ 000671 DBA/2J 007048 DBA/2J-Gpnmb+/SjJ 002106 KK/HlJ 000675 LG/J 000676 LP/J 000677 MA/MyJ 001976 NOD/ShiLtJ 002050 NOR/LtJ 000679 P/J 002747 SENCARB/PtJ 002335 SKH2/J 003392 STOCK Crb1rd8/J 000275 V/LeJ View Strains carrying other alleles of Cdh23 (47 strains)
Additional Web Information
Congenic Nomenclature
Animal Health Reports
Room Number A1
Research Applications
This mouse can be used to support research in many areas including:Cdh23Ahl+ related
Neurobiology Research
Vestibular and Hearing Defects (Age related hearing loss, control)
Sensorineural Research
Vestibular and Hearing Defects (Age related hearing loss, control)
References
Selected Reference(s)
Additional ReferencesJohnson KR; Erway LC; Cook SA; Willott JF; Zheng QY. 1997. A major gene affecting age-related hearing loss in C57BL/6J mice Hear Res 114(1-2):83-92. [PubMed: 9447922] [J:44966]
Price and Supply Information
| Strain Name: | B6.CAST-Cdh23Ahl+/Kjn |
| Stock Number: | 002756 |
Price Details
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Supply Details
| Standard Supply | Repository-Live. No age specifications accepted. Colony sized to produce minimal quantities (typically up to 6 mice) upon order receipt; one order per strain. Expected delivery: 1-3 months. Larger quantities or custom orders arranged upon request. |
|---|---|
| Supply Notes |
Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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