Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names C3.Cg-scb/J    (Changed: 04-FEB-05 ) C3.Cg-scb/+    (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain C3HeB/FeJ

Appearance
skin and tail defects
Related Genotype: scb/scb

unaffected
Related Genotype: scb/+

Description
Scabby is a recessive mutation that maps to chromosome 8. Homozygotes display scar tissue on the skin and tail shortly after birth with defects in hair growth in these areas. Transverse stripes particularly over the rump may be seen in the juvenile coat, but are generally absent in the adult. Webbed feet and a short and kinky or constricted tail may also be seen. Homozygotes are viable and fertile although males breed better than females. (Searle and Beechey, 1977.)

Development
The scb mutation arose spontaneously at Harwell in 1976 on the C3H/HeH background. The line was maintained primarily through sibling matings of homozygotes with occasional outcrossing to (C3H/HeH x 101H)F1. In 1987 homozygous males of the 17th generation were bred with (C3H/HeH x 101H)F1 females to generate embryos for cryopreservation. In 1995 some of these heterozygous embryos were transferred from Harwell to The Jackson Laboratory where they were thawed, reared, and sibling bred. This mutation was then moved onto the C3HeB/FeJ background via backcross-intercross breeding and in 2003 this strain reached NE7. It was then maintained by sibling breeding heterozygotes with homozygotes, with a preference for the homozygote to be a male since they are better breeders than homozygous females. In 2005 this strain was cryopreserved at The Jackson Laboratory using C3HeB/FeJ females and homozygous males at N7F5.

Control Information

	Control
	Heterozygote from the colony
Considerations for Choosing Controls

Additional Web Information

Congenic Nomenclature

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

scb/scb

        C3H/HeH-scb

• limbs/digits/tail phenotype
• abnormal skeleton extremities morphology (MGI Ref ID J:13719)
• abnormal tail morphology (MGI Ref ID J:13719)
• kinked tail (MGI Ref ID J:13719)
• short tail (MGI Ref ID J:13719)
  • may have constrictions
• skeleton phenotype
• *normal* skeleton phenotype (MGI Ref ID J:13719)
• abnormal skeleton extremities morphology (MGI Ref ID J:13719)
• skin/coat/nails phenotype
• abnormal coat/ hair morphology (MGI Ref ID J:13719)
• abnormal coat appearance (MGI Ref ID J:13719)
  • dark transverse stripes appear in the juvenile (agouti) coat forming from the damaged skin areas but disappear after subsequent hair cycles
  • adult coat may appear normal
• abnormal hair growth (MGI Ref ID J:13719)
  • occurs in scabby areas on the body
  • dark transverse stripes appear in the juvenile coat forming from the damaged skin areas but disappear after subsequent hair cycles
• abnormal skin condition/ morphology (MGI Ref ID J:13719)
• abnormal skin condition (MGI Ref ID J:13719)
• scaly skin (MGI Ref ID J:13719)
  • observed shortly after birth
  • displays as transverse areas of scar tissue especially in the lumbar region with similar regions on the legs and tail
• cellular phenotype
• abnormal chromosome morphology (MGI Ref ID J:4646)
• elevated level of sister chromatid exchange (MGI Ref ID J:4646)
  • observation made using primary embryonic cell cultures

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

scb related

Dermatology Research
Skin and Hair Texture Defects

Developmental Biology Research
Skeletal Defects
Skin and Hair Texture Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol		scb
Allele Name		scabby
Allele Type		Spontaneous
Strain of Origin		C3H/HeH
Gene Symbol and Name		scb, scabby
Chromosome		8

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

scb related

Searle AG; Beechey CV. 1977. Scabby Mouse News Lett 57:16.  [MGI Ref ID J:13719]

van Buul PP; Tuinenburg-Bol Raap A; Goudzwaard HJ; Seelen CM; Beechey CV; Natarajan AT; Searle AG. 1991. Cytogenetic characterization of radiosensitive mouse mutants. Mutat Res 251(2):171-9. [PubMed: 1720867]  [MGI Ref ID J:4646]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.

Supply Notes

Cryopreserved Embryos This strain is also available as cryopreserved embryos from our Repository. Orders for cryopreserved embryos are supplied subject to a signed agreement that must be returned to the Customer Service Department after order placement. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos from our repository, please visit our Cryopreserved Embryos web page. Cryorecovery - Standard. At least two mice that carry the mutation (if it is a mutant strain) will be provided. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotypes and genders are needed. IMPORTANT NOTE: The genotypes of the animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire for possible genotypes for this specific strain. Animals typically ship within 13 to 16 weeks from your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will typically ship within 25 weeks. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	Heterozygote from the colony
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

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In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.