Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names FVB/N-TgN(MtTPRMET)773    (Changed: 15-DEC-04 ) Type Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation F3+1p   Donating Investigator Timothy Wang,   Univ. of Massachusetts Medical Center

Description
Mammary tumors developed at around a year of age in multiparous mice. Multiple tumors classified as independent arose in several mice. No metastases were observed. Hyperplastic alveolar nodules were identified in most multiparous mice and several also had foci of microscopic carcinoma. Tumors exhibited scirrhous, papillary, or nodular histologic patterns. Other tumor types seen included diffuse lymphoblastic lymphomas involving the mammary gland and lymph nodes, thymic lymphoma, spindle cell sarcoma, and orbital giant cell osteosarcoma.

Control Information

	Control
	001800 FVB/NJ
Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of MET

008695	FVB-Tg(tetO-MET)23Rwng/J
002675	FVB/N-Tg(MtTPRMET)243Lng/J

View Strains carrying other alleles of MET     (2 strains)

Strains carrying other alleles of Mt1

002211	129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
002210	B6.Cg-Tg(Mt1)174Bri/J
003210	C57BL/6-Tg(Crh)227.1Pbl/J
002599	C57BL/6-Tg(ML5sHEL)5Ccg/J
002193	C57BL/6J-Tg(MTn-lacZ)204Bri/J
005968	C57BL/6J-Tg(Mt1-Tnfsf4)2Pgn/Pgn
002028	D2.Cg-Tg(pHRD)1Ust/J
002421	FVB/N-Tg(MtTGFA)100Lmb/J
002675	FVB/N-Tg(MtTPRMET)243Lng/J
006610	NOD.B6-Tg(ML5sHEL)5Ccg/DvsJ
002209	STOCK Tg(Mt1)174Bri/J
002422	STOCK Tg(MtTGFA)42Lmb/J
003722	SW.Cg-Tg(MtTGFA)42Lmb/J

View Strains carrying other alleles of Mt1     (13 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

Tg(MtTPRMET)773Lng/0

        FVB/N-Tg(MtTPRMET)773Lng

• tumorigenesis
• mammary gland tumor (MGI Ref ID J:71573)
  • all multiparous female mice develop scirrhous, papillary, or nodular mammary tumors
• sarcoma (MGI Ref ID J:71573)
  • female mice develop spindle cell sarcomas
• endocrine/exocrine gland phenotype
• mammary alveolar hyperplasia (MGI Ref ID J:71573)
  • multiparous females exhibit hypoplastic alveolar nodules
• reproductive system phenotype
• mammary alveolar hyperplasia (MGI Ref ID J:71573)
  • multiparous females exhibit hypoplastic alveolar nodules

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

MET related

Cancer Research
Increased Tumor Incidence (Mammary Gland Tumors)

Mt1 related

Metabolism Research

Genes & Alleles

Gene & Allele Information

Allele Symbol		Tg(MtTPRMET)773Lng
Allele Name		transgene insertion 773, T Jake Liang
Allele Type		Transgenic (random, expressed)
Common Name(s)		MTM2;
Mutation Made By		Timothy Wang,   Univ. of Massachusetts Medical Center
Strain of Origin		FVB/N
Expressed Gene		MET, met proto-oncogene (hepatocyte growth factor receptor), human
Promoter		Mt1, metallothionein 1, mouse, laboratory
Molecular Note		The transgene contains a mouse metallothionein 1 promoter and the human met proto-oncogene (hepatocyte growth factor receptor). Four founder lines were established (line 1 = 243 and line 2 = 773). [MGI Ref ID J:71573]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Liang TJ; Reid AE; Xavier R; Cardiff RD; Wang TC. 1996. Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors. J Clin Invest 97(12):2872-7. [PubMed: 8675700]  [MGI Ref ID J:71573]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.

Supply Notes

Cryorecovery - Standard. At least two mice that carry the mutation (if it is a mutant strain) will be provided. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotypes and genders are needed. IMPORTANT NOTE: The genotypes of the animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire for possible genotypes for this specific strain. Animals typically ship within 13 to 16 weeks from your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will typically ship within 25 weeks. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845. This strain is included in the Induced Mutant Resource Colony collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	001800 FVB/NJ
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

      Purchasing Information
      JAX^® Mice Orders
      Surgical Services

Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

OncoMouse^® requires a license from DuPont, see Licenses for Strains with OncoMouse^® Technology.

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

No Liability

In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.