Strain Name:

B6;129P2-Ccr5tm1Kuz/J

Stock Number:

002782

Order this mouse

Availability:

Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6;129P2-Cmkbr5tm1Kuz    (Changed: 15-DEC-04 )
Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
 
Donating InvestigatorDr. William A. Kuziel,   Protein Design Laboratories

Appearance
black
Related Genotype: a/a

Description
At birth, mice homozygous for the targeted allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. No transcript is detected in splenocytes or peritoneal macrophages. Thioglycollate-elicited peritoneal macrophages from homozygotes exhibit a delayed period before reaching peak mobilization (72 hours vs. 36 for wild type mice).

Development
A targeting vector containing a neomycin resistance gene was used to disrupt the single coding exon of the targeted gene. The construct was electroporated into 129P2/OlaHsd-derived E14TG2A embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. Correctly targeted ES cells were injected into C57BL/6J blastocysts to obtain chimeric animals.

Control Information

  Control
   100903 B6129PF2/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Ccr5tm1Kuz allele
005427   B6.129P2-Ccr5tm1Kuz/J
View Strains carrying   Ccr5tm1Kuz     (1 strain)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Diabetes Mellitus, Insulin-Dependent, 22; IDDM22   (CCR5)
Hepatitis C Virus, Susceptibility to   (CCR5)
West Nile Virus, Susceptibility to   (CCR5)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Ccr5tm1Kuz/Ccr5tm1Kuz

        involves: 129P2/OlaHsd * C57BL/6
  • immune system phenotype
  • abnormal CD4-positive T cell morphology
    • intestinal mucosa shows enhanced infiltration of CD4+ lymphocytes by day 7 compared to wild-type or Ccr2-deficient mice   (MGI Ref ID J:110814)
    • mice have an increased number of CD4+ T cells before and during DSS-induced colitis   (MGI Ref ID J:110814)
  • abnormal CD8-positive T cell morphology   (MGI Ref ID J:110814)
  • abnormal Kupffer cell morphology
    • infiltration of Kupffer cells an NK cells is strongly reduced after bile duct ligation   (MGI Ref ID J:152548)
    • mediates liver fibrosis primarily through resident liver cells   (MGI Ref ID J:152548)
  • abnormal NK T cell physiology
    • increased resistance to activation induced cell death   (MGI Ref ID J:100869)
    • increased numbers of Il4 producing cells   (MGI Ref ID J:100869)
    • increased FasL expressing cells   (MGI Ref ID J:100869)
  • abnormal cytokine level
    • mice expression one fifth the wild-type level of Ifng after day 3 and 7, while Il-4 is increased 75-fold and a 2-fold increase in Il-5 and -10 over wild-type   (MGI Ref ID J:110814)
  • abnormal microglial cell activation
    • significant reduction in activated microglia in the hippocampus 8 hours after injection of beta amyloid 1-40   (MGI Ref ID J:153059)
  • decreased NK cell number
    • 4 fold reduction of tumor infiltrating NK cells when mice are injected with B16 melanoma cells   (MGI Ref ID J:135308)
  • decreased susceptibility to induced colitis
    • null mice show clinically less severe DSS-mediated colitis than wild-type or Ccr2-nulls   (MGI Ref ID J:110814)
  • decreased susceptibility to viral infection
    • abrogated neurotoxicity to gp120 from a CCR5 preferring isolate of HIV   (MGI Ref ID J:132342)
    • abrogated neurotoxicity to gp120 from a CCR4 preferring isolate of HIV   (MGI Ref ID J:132342)
  • impaired macrophage chemotaxis
    • 80% fewer macrophages compared to control in Ag-loaded gelatin sponge DTH assay   (MGI Ref ID J:64293)
    • delay in induced peritoneal macrophage accumulation, however, accumulation of neutrophils/eosinophils is unchanged   (MGI Ref ID J:84243)
    • reduced chemotaxis response   (MGI Ref ID J:153059)
  • increased NK T cell number
    • null mice show a significant increase in NK 1.1+ T cells by day 3 and 7 of DSS-treatment; wild-type and Ccr2-null mice do not show as large of an increase   (MGI Ref ID J:110814)
  • increased susceptibility to fungal infection
    • reduced survival following inoculation with Cryptococcus neoformans, 40% die by week 8 due to CNS infection (hydrocephalus)   (MGI Ref ID J:64293)
    • infected mice exhibit increased mononuclear cell recruitment to lungs, but not brain   (MGI Ref ID J:64293)
    • by week 5 infected mice exhibit cryptococcal meningitis cranial swelling, ruffled fur, staggered gait, lethargy and unresponsiveness, and decreased limb function   (MGI Ref ID J:64293)
    • brains of infected mice develop loss of neural tissue integrity , and large amounts of extracellelular cryptococcal polysaccharide capsule   (MGI Ref ID J:64293)
  • behavior/neurological phenotype
  • abnormal locomotor behavior
    • mice show little reduction in activity with DSS treatment, unlike wild-type which become very lethargic with time   (MGI Ref ID J:110814)
  • abnormal long term spatial reference memory
    • in a Morris water maze   (MGI Ref ID J:153059)
  • abnormal spatial learning
    • improved learning performance in a Morris water maze after injection of beta amyloid 1-40 relative to controls   (MGI Ref ID J:153059)
  • digestive/alimentary phenotype
  • decreased susceptibility to induced colitis
    • null mice show clinically less severe DSS-mediated colitis than wild-type or Ccr2-nulls   (MGI Ref ID J:110814)
  • hematopoietic system phenotype
  • abnormal CD4-positive T cell morphology
    • intestinal mucosa shows enhanced infiltration of CD4+ lymphocytes by day 7 compared to wild-type or Ccr2-deficient mice   (MGI Ref ID J:110814)
    • mice have an increased number of CD4+ T cells before and during DSS-induced colitis   (MGI Ref ID J:110814)
  • abnormal CD8-positive T cell morphology   (MGI Ref ID J:110814)
  • abnormal Kupffer cell morphology
    • infiltration of Kupffer cells an NK cells is strongly reduced after bile duct ligation   (MGI Ref ID J:152548)
    • mediates liver fibrosis primarily through resident liver cells   (MGI Ref ID J:152548)
  • abnormal NK T cell physiology
    • increased resistance to activation induced cell death   (MGI Ref ID J:100869)
    • increased numbers of Il4 producing cells   (MGI Ref ID J:100869)
    • increased FasL expressing cells   (MGI Ref ID J:100869)
  • abnormal microglial cell activation
    • significant reduction in activated microglia in the hippocampus 8 hours after injection of beta amyloid 1-40   (MGI Ref ID J:153059)
  • decreased NK cell number
    • 4 fold reduction of tumor infiltrating NK cells when mice are injected with B16 melanoma cells   (MGI Ref ID J:135308)
  • impaired macrophage chemotaxis
    • 80% fewer macrophages compared to control in Ag-loaded gelatin sponge DTH assay   (MGI Ref ID J:64293)
    • delay in induced peritoneal macrophage accumulation, however, accumulation of neutrophils/eosinophils is unchanged   (MGI Ref ID J:84243)
    • reduced chemotaxis response   (MGI Ref ID J:153059)
  • increased NK T cell number
    • null mice show a significant increase in NK 1.1+ T cells by day 3 and 7 of DSS-treatment; wild-type and Ccr2-null mice do not show as large of an increase   (MGI Ref ID J:110814)
  • homeostasis/metabolism phenotype
  • abnormal cytokine level
    • mice expression one fifth the wild-type level of Ifng after day 3 and 7, while Il-4 is increased 75-fold and a 2-fold increase in Il-5 and -10 over wild-type   (MGI Ref ID J:110814)
  • cellular phenotype
  • impaired macrophage chemotaxis
    • 80% fewer macrophages compared to control in Ag-loaded gelatin sponge DTH assay   (MGI Ref ID J:64293)
    • delay in induced peritoneal macrophage accumulation, however, accumulation of neutrophils/eosinophils is unchanged   (MGI Ref ID J:84243)
    • reduced chemotaxis response   (MGI Ref ID J:153059)
  • nervous system phenotype
  • abnormal nervous system physiology
    • abrogated neurotoxicity to gp120 from a CCR5 preferring isolate of HIV   (MGI Ref ID J:132342)
    • abrogated neurotoxicity to gp120 from a CCR4 preferring isolate of HIV   (MGI Ref ID J:132342)
    • abnormal glial cell physiology   (MGI Ref ID J:153059)
      • abnormal astrocyte physiology
        • significant reduction in activated astrocytes in the hippocampus 6 hours after injection of beta amyloid 1-40   (MGI Ref ID J:153059)
      • abnormal microglial cell activation
        • significant reduction in activated microglia in the hippocampus 8 hours after injection of beta amyloid 1-40   (MGI Ref ID J:153059)
  • cardiovascular system phenotype
  • abnormal Kupffer cell morphology
    • infiltration of Kupffer cells an NK cells is strongly reduced after bile duct ligation   (MGI Ref ID J:152548)
    • mediates liver fibrosis primarily through resident liver cells   (MGI Ref ID J:152548)
  • liver/biliary system phenotype
  • abnormal Ito cell morphology
    • complete suppression of hepatic stellate cell migration   (MGI Ref ID J:152548)
  • abnormal Kupffer cell morphology
    • infiltration of Kupffer cells an NK cells is strongly reduced after bile duct ligation   (MGI Ref ID J:152548)
    • mediates liver fibrosis primarily through resident liver cells   (MGI Ref ID J:152548)
  • abnormal hepatocyte physiology
    • injection of Concanavalin A results in 25% increase in damage   (MGI Ref ID J:100869)
    • hepatocellular necrosis   (MGI Ref ID J:100869)
  • liver failure
    • injection of Concanavalin A leads to fulminant liver failure and 50% mortality within 8 hours whereas all controls survive   (MGI Ref ID J:100869)
    • antibody depletion of NKT cells improves liver damage   (MGI Ref ID J:100869)
    • IL4 depletion improves liver damage   (MGI Ref ID J:100869)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Ccr5tm1Kuz/Ccr5tm1Kuz

        B6.129P2-Ccr5tm1Kuz
  • behavior/neurological phenotype
  • *normal* behavior/neurological phenotype
    • response to kainic acid similar to controls   (MGI Ref ID J:84037)
    • become catatonic and display staring behavior within 15 minutes   (MGI Ref ID J:84037)
    • myoclonic twitching, frequent rearing and falling   (MGI Ref ID J:84037)
    • seizures lasting up to 5 hours   (MGI Ref ID J:84037)
    • abnormal conditioned taste aversion behavior
      • female mice develop a stronger ethanol-induced conditioned taste aversion compared with similarly treated wild-type mice   (MGI Ref ID J:102583)
    • increased fluid intake
      • of an ethanol, saccharin, or quinine solution   (MGI Ref ID J:102583)
      • increased alcohol consumption
        • in female but not male mice   (MGI Ref ID J:102583)
  • mortality/aging
  • *normal* mortality/aging
    • 40% mortality after kainic acid treatment   (MGI Ref ID J:84037)
  • nervous system phenotype
  • *normal* nervous system phenotype
    • selective CA3 hippocampal pycnosis after kainic acid treatment as in controls   (MGI Ref ID J:84037)
    • susceptibility of cerebral granule cell neurons to kainic acid is similar to controls   (MGI Ref ID J:84037)
  • vision/eye phenotype
  • corneal vascularization
    • 34% less neovascularization than controls 2 weeks after denudation of corneal epithelium   (MGI Ref ID J:118018)
    • 34.9% less neovascularization than controls 4 weeks after denudation of corneal epithelium   (MGI Ref ID J:118018)
  • cardiovascular system phenotype
  • corneal vascularization
    • 34% less neovascularization than controls 2 weeks after denudation of corneal epithelium   (MGI Ref ID J:118018)
    • 34.9% less neovascularization than controls 4 weeks after denudation of corneal epithelium   (MGI Ref ID J:118018)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Ccr5tm1Kuz related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ccr5tm1Kuz
Allele Name targeted mutation 1, William A Kuziel
Allele Type Targeted (Null/Knockout)
Common Name(s) CCR5 KO; CCR5-; Cmkbr5tm1Kuz;
Mutation Made ByDr. William Kuziel,   Protein Design Laboratories
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14TG2a
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Ccr5, chemokine (C-C motif) receptor 5
Chromosome 9
Gene Common Name(s) CC-CKR-5; CCCKR5; CCR-5; CD195; CKR-5; CKR5; CMKBR5; Cmkbr5; IDDM22; chemokine (C-C) receptor 5;
Molecular Note The exon containing the entire coding region was replaced with a neomycin resistance gene inserted by homologous recombination. [MGI Ref ID J:84243]

Genotyping

Genotyping Information

Genotyping Protocols

Ccr5tm1Kuz MCA, Melt Curve Analysis
Ccr5tm1Kuz, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Kuziel WA; Dawson TC; Quinones M; Garavito E; Chenaux G; Ahuja SS; Reddick RL; Maeda N. 2003. CCR5 deficiency is not protective in the early stages of atherogenesis in apoE knockout mice. Atherosclerosis 167(1):25-32. [PubMed: 12618265]  [MGI Ref ID J:84243]

Additional References

Algood HM; Flynn JL. 2004. CCR5-deficient mice control Mycobacterium tuberculosis infection despite increased pulmonary lymphocytic infiltration. J Immunol 173(5):3287-96. [PubMed: 15322191]  [MGI Ref ID J:92716]

Belnoue E; Kayibanda M; Deschemin JC; Viguier M; Mack M; Kuziel WA; Renia L. 2003. CCR5 deficiency decreases susceptibility to experimental cerebral malaria. Blood 101(11):4253-9. [PubMed: 12560237]  [MGI Ref ID J:83961]

Mecsas J; Franklin G; Kuziel WA; Brubaker RR; Falkow S; Mosier DE. 2004. Evolutionary genetics: CCR5 mutation and plague protection. Nature 427(6975):606. [PubMed: 14961112]  [MGI Ref ID J:88162]

Moore BB; Paine R rd; Christensen PJ; Moore TA; Sitterding S; Ngan R; Wilke CA; Kuziel WA; Toews GB. 2001. Protection from pulmonary fibrosis in the absence of CCR2 signaling. J Immunol 167(8):4368-77. [PubMed: 11591761]  [MGI Ref ID J:82885]

Nansen A; Christensen JP; Andreasen S SO; Bartholdy C; Christensen JE; Thomsen AR. 2002. The role of CC chemokine receptor 5 in antiviral immunity. Blood 99(4):1237-45. [PubMed: 11830471]  [MGI Ref ID J:74713]

Yopp AC; Fu S; Honig SM; Randolph GJ; Ding Y; Krieger NR; Bromberg JS. 2004. FTY720-enhanced T cell homing is dependent on CCR2, CCR5, CCR7, and CXCR4: evidence for distinct chemokine compartments. J Immunol 173(2):855-65. [PubMed: 15240672]  [MGI Ref ID J:91926]

Ccr5tm1Kuz related

Abonia JP; Austen KF; Rollins BJ; Joshi SK; Flavell RA; Kuziel WA; Koni PA; Gurish MF. 2005. Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2. Blood 105(11):4308-13. [PubMed: 15705791]  [MGI Ref ID J:98967]

Ajuebor MN; Aspinall AI; Zhou F; Le T; Yang Y; Urbanski SJ; Sidobre S; Kronenberg M; Hogaboam CM; Swain MG. 2005. Lack of chemokine receptor CCR5 promotes murine fulminant liver failure by preventing the apoptosis of activated CD1d-restricted NKT cells. J Immunol 174(12):8027-37. [PubMed: 15944310]  [MGI Ref ID J:100869]

Ajuebor MN; Wondimu Z; Hogaboam CM; Le T; Proudfoot AE; Swain MG. 2007. CCR5 deficiency drives enhanced natural killer cell trafficking to and activation within the liver in murine T cell-mediated hepatitis. Am J Pathol 170(6):1975-88. [PubMed: 17525265]  [MGI Ref ID J:122162]

Algood HM; Flynn JL. 2004. CCR5-deficient mice control Mycobacterium tuberculosis infection despite increased pulmonary lymphocytic infiltration. J Immunol 173(5):3287-96. [PubMed: 15322191]  [MGI Ref ID J:92716]

Aliberti J; Valenzuela JG; Carruthers VB; Hieny S; Andersen J; Charest H; Reis e Sousa C; Fairlamb A; Ribeiro JM; Sher A. 2003. Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells. Nat Immunol 4(5):485-90. [PubMed: 12665855]  [MGI Ref ID J:125439]

Ambati BK; Anand A; Joussen AM; Kuziel WA; Adamis AP; Ambati J. 2003. Sustained inhibition of corneal neovascularization by genetic ablation of CCR5. Invest Ophthalmol Vis Sci 44(2):590-3. [PubMed: 12556387]  [MGI Ref ID J:118018]

Andres PG; Beck PL; Mizoguchi E; Mizoguchi A; Bhan AK; Dawson T; Kuziel WA; Maeda N; MacDermott RP; Podolsky DK; Reinecker HC. 2000. Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis: lack of CC chemokine receptor 5 expression results in a NK1.1+ lymphocyte-associated Th2-type immune response in the intestine. J Immunol 164(12):6303-12. [PubMed: 10843684]  [MGI Ref ID J:110814]

Ank N; Petersen K; Malmgaard L; Mogensen SC; Paludan SR. 2005. Age-dependent role for CCR5 in antiviral host defense against herpes simplex virus type 2. J Virol 79(15):9831-41. [PubMed: 16014944]  [MGI Ref ID J:100102]

Ariel A; Fredman G; Sun YP; Kantarci A; Van Dyke TE; Luster AD; Serhan CN. 2006. Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression. Nat Immunol 7(11):1209-16. [PubMed: 17013391]  [MGI Ref ID J:113563]

Baba T; Nakamoto Y; Mukaida N. 2009. Crucial contribution of thymic Sirpalpha+ conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent manner. J Immunol 183(5):3053-63. [PubMed: 19675159]  [MGI Ref ID J:151848]

Belnoue E; Kayibanda M; Deschemin JC; Viguier M; Mack M; Kuziel WA; Renia L. 2003. CCR5 deficiency decreases susceptibility to experimental cerebral malaria. Blood 101(11):4253-9. [PubMed: 12560237]  [MGI Ref ID J:83961]

Bierly AL; Shufesky WJ; Sukhumavasi W; Morelli AE; Denkers EY. 2008. Dendritic cells expressing plasmacytoid marker PDCA-1 are Trojan horses during Toxoplasma gondii infection. J Immunol 181(12):8485-91. [PubMed: 19050266]  [MGI Ref ID J:142065]

Blednov YA; Bergeson SE; Walker D; Ferreira VM; Kuziel WA; Harris RA. 2005. Perturbation of chemokine networks by gene deletion alters the reinforcing actions of ethanol. Behav Brain Res 165(1):110-25. [PubMed: 16105698]  [MGI Ref ID J:102583]

Braunersreuther V; Zernecke A; Arnaud C; Liehn EA; Steffens S; Shagdarsuren E; Bidzhekov K; Burger F; Pelli G; Luckow B; Mach F; Weber C. 2007. Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice. Arterioscler Thromb Vasc Biol 27(2):373-9. [PubMed: 17138939]  [MGI Ref ID J:128063]

Camargo JF; Quinones MP; Mummidi S; Srinivas S; Gaitan AA; Begum K; Jimenez F; VanCompernolle S; Unutmaz D; Ahuja SS; Ahuja SK. 2009. CCR5 expression levels influence NFAT translocation, IL-2 production, and subsequent signaling events during T lymphocyte activation. J Immunol 182(1):171-82. [PubMed: 19109148]  [MGI Ref ID J:142900]

Carr DJ; Ash J; Lane TE; Kuziel WA. 2006. Abnormal immune response of CCR5-deficient mice to ocular infection with herpes simplex virus type 1. J Gen Virol 87(Pt 3):489-99. [PubMed: 16476970]  [MGI Ref ID J:135791]

Castellino F; Huang AY; Altan-Bonnet G; Stoll S; Scheinecker C; Germain RN. 2006. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature 440(7086):890-5. [PubMed: 16612374]  [MGI Ref ID J:107629]

Chang LY; Lin YC; Kang CW; Hsu CY; Chu YY; Huang CT; Day YJ; Chen TC; Yeh CT; Lin CY. 2012. The indispensable role of CCR5 for in vivo suppressor function of tumor-derived CD103+ effector/memory regulatory T cells. J Immunol 189(2):567-74. [PubMed: 22664873]  [MGI Ref ID J:189562]

Chang LY; Lin YC; Mahalingam J; Huang CT; Chen TW; Kang CW; Peng HM; Chu YY; Chiang JM; Dutta A; Day YJ; Chen TC; Yeh CT; Lin CY. 2012. Tumor-Derived Chemokine CCL5 Enhances TGF-beta-Mediated Killing of CD8+ T Cells in Colon Cancer by T-Regulatory Cells. Cancer Res 72(5):1092-102. [PubMed: 22282655]  [MGI Ref ID J:181486]

Chantakru S; Kuziel WA; Maeda N; Croy BA. 2001. A study on the density and distribution of uterine natural killer cells at mid pregnancy in mice genetically-ablated for CCR2, CCR 5 and the CCR5 receptor ligand, MIP-1alpha J Reprod Immunol 49(1):33-47. [PubMed: 11137111]  [MGI Ref ID J:66438]

Chen Z; Yu S; Bakhiet M; Winblad B; Zhu J. 2003. The chemokine receptor CCR5 is not a necessary inflammatory mediator in kainic acid-induced hippocampal injury: evidence for a compensatory effect by increased CCR2 and CCR3. J Neurochem 86(1):61-8. [PubMed: 12807425]  [MGI Ref ID J:84037]

Chiu BC; Freeman CM; Stolberg VR; Hu JS; Zeibecoglou K; Lu B; Gerard C; Charo IF; Lira SA; Chensue SW. 2004. Impaired lung dendritic cell activation in CCR2 knockout mice. Am J Pathol 165(4):1199-209. [PubMed: 15466386]  [MGI Ref ID J:93675]

Chiu BC; Martin BE; Stolberg VR; Chensue SW. 2013. Cutting edge: Central memory CD8 T cells in aged mice are virtual memory cells. J Immunol 191(12):5793-6. [PubMed: 24227783]  [MGI Ref ID J:207125]

Christmann BS; Moran JM; McGraw JA; Buller RM; Corbett JA. 2011. Ccr5 regulates inflammatory gene expression in response to encephalomyocarditis virus infection. Am J Pathol 179(6):2941-51. [PubMed: 22001348]  [MGI Ref ID J:180065]

Cochain C; Rodero MP; Vilar J; Recalde A; Richart AL; Loinard C; Zouggari Y; Guerin C; Duriez M; Combadiere B; Poupel L; Levy BI; Mallat Z; Combadiere C; Silvestre JS. 2010. Regulation of monocyte subset systemic levels by distinct chemokine receptors controls post-ischaemic neovascularization. Cardiovasc Res 88(1):186-95. [PubMed: 20501509]  [MGI Ref ID J:182115]

Crawford A; Angelosanto JM; Nadwodny KL; Blackburn SD; Wherry EJ. 2011. A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection. PLoS Pathog 7(7):e1002098. [PubMed: 21814510]  [MGI Ref ID J:183343]

Cripps JG; Celaj S; Burdick M; Strieter RM; Gorham JD. 2012. Liver inflammation in a mouse model of Th1 hepatitis despite the absence of invariant NKT cells or the Th1 chemokine receptors CXCR3 and CCR5. Lab Invest 92(10):1461-71. [PubMed: 22906987]  [MGI Ref ID J:189898]

Dawson TC; Beck MA; Kuziel WA; Henderson F; Maeda N. 2000. Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus. Am J Pathol 156(6):1951-9. [PubMed: 10854218]  [MGI Ref ID J:62675]

DePaolo RW; Lathan R; Karpus WJ. 2004. CCR5 regulates high dose oral tolerance by modulating CC chemokine ligand 2 levels in the GALT. J Immunol 173(1):314-20. [PubMed: 15210789]  [MGI Ref ID J:90955]

Dobaczewski M; Xia Y; Bujak M; Gonzalez-Quesada C; Frangogiannis NG. 2010. CCR5 signaling suppresses inflammation and reduces adverse remodeling of the infarcted heart, mediating recruitment of regulatory T cells. Am J Pathol 176(5):2177-87. [PubMed: 20382703]  [MGI Ref ID J:160376]

Fadel SA; Bromley SK; Medoff BD; Luster AD. 2008. CXCR3-deficiency protects influenza-infected CCR5-deficient mice from mortality. Eur J Immunol 38(12):3376-3387. [PubMed: 19039768]  [MGI Ref ID J:141370]

Fischer FR; Luo Y; Luo M; Santambrogio L; Dorf ME. 2001. RANTES-induced chemokine cascade in dendritic cells. J Immunol 167(3):1637-43. [PubMed: 11466387]  [MGI Ref ID J:120465]

Fukuyama Y; Tokuhara D; Sekine S; Aso K; Kataoka K; Davydova J; Yamamoto M; Gilbert RS; Tokuhara Y; Fujihashi K; Kunisawa J; Yuki Y; Kiyono H; McGhee JR; Fujihashi K. 2013. Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses. PLoS One 8(4):e60453. [PubMed: 23565250]  [MGI Ref ID J:199945]

Glass WG; Lim JK; Cholera R; Pletnev AG; Gao JL; Murphy PM. 2005. Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection. J Exp Med 202(8):1087-98. [PubMed: 16230476]  [MGI Ref ID J:116832]

Gonzalez-Martin A; Gomez L; Lustgarten J; Mira E; Manes S. 2011. Maximal T Cell-Mediated Antitumor Responses Rely upon CCR5 Expression in Both CD4+ and CD8+ T Cells. Cancer Res 71(16):5455-66. [PubMed: 21715565]  [MGI Ref ID J:175447]

Goser S; Ottl R; Brodner A; Dengler TJ; Torzewski J; Egashira K; Rose NR; Katus HA; Kaya Z. 2005. Critical role for monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha in induction of experimental autoimmune myocarditis and effective anti-monocyte chemoattractant protein-1 gene therapy. Circulation 112(22):3400-7. [PubMed: 16316965]  [MGI Ref ID J:116910]

Gregg RK; Nichols L; Chen Y; Lu B; Engelhard VH. 2010. Mechanisms of spatial and temporal development of autoimmune vitiligo in tyrosinase-specific TCR transgenic mice. J Immunol 184(4):1909-17. [PubMed: 20083666]  [MGI Ref ID J:159480]

Hallgren J; Jones TG; Abonia JP; Xing W; Humbles A; Austen KF; Gurish MF. 2007. Pulmonary CXCR2 regulates VCAM-1 and antigen-induced recruitment of mast cell progenitors. Proc Natl Acad Sci U S A 104(51):20478-83. [PubMed: 18077323]  [MGI Ref ID J:130586]

Hamrah P; Yamagami S; Liu Y; Zhang Q; Vora SS; Lu B; Gerard CJ; Dana MR. 2007. Deletion of the chemokine receptor CCR1 prolongs corneal allograft survival. Invest Ophthalmol Vis Sci 48(3):1228-36. [PubMed: 17325167]  [MGI Ref ID J:123260]

Hardison JL; Wrightsman RA; Carpenter PM; Kuziel WA; Lane TE; Manning JE. 2006. The CC chemokine receptor 5 is important in control of parasite replication and acute cardiac inflammation following infection with Trypanosoma cruzi. Infect Immun 74(1):135-43. [PubMed: 16368966]  [MGI Ref ID J:104277]

Herold S; von Wulffen W; Steinmueller M; Pleschka S; Kuziel WA; Mack M; Srivastava M; Seeger W; Maus UA; Lohmeyer J. 2006. Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules. J Immunol 177(3):1817-24. [PubMed: 16849492]  [MGI Ref ID J:137974]

Hickman HD; Li L; Reynoso GV; Rubin EJ; Skon CN; Mays JW; Gibbs J; Schwartz O; Bennink JR; Yewdell JW. 2011. Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells. J Exp Med 208(12):2511-24. [PubMed: 22042976]  [MGI Ref ID J:178641]

Huffnagle GB; McNeil LK; McDonald RA; Murphy JW; Toews GB; Maeda N; Kuziel WA. 1999. Cutting edge: Role of C-C chemokine receptor 5 in organ-specific and innate immunity to Cryptococcus neoformans. J Immunol 163(9):4642-6. [PubMed: 10528159]  [MGI Ref ID J:64293]

Hugues S; Scholer A; Boissonnas A; Nussbaum A; Combadiere C; Amigorena S; Fetler L. 2007. Dynamic imaging of chemokine-dependent CD8(+) T cell help for CD8(+) T cell responses. Nat Immunol 8(9):921-30. [PubMed: 17660821]  [MGI Ref ID J:124274]

Ibrahim HM; Bannai H; Xuan X; Nishikawa Y. 2009. Toxoplasma gondii cyclophilin 18-mediated production of nitric oxide induces Bradyzoite conversion in a CCR5-dependent manner. Infect Immun 77(9):3686-95. [PubMed: 19564392]  [MGI Ref ID J:152248]

Islam SA; Chang DS; Colvin RA; Byrne MH; McCully ML; Moser B; Lira SA; Charo IF; Luster AD. 2011. Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells. Nat Immunol 12(2):167-77. [PubMed: 21217759]  [MGI Ref ID J:168253]

Kalkonde YV; Shelton R; Villarreal M; Sigala J; Mishra PK; Ahuja SS; Barea-Rodriguez E; Moretti P; Ahuja SK. 2011. The CC chemokine receptor 5 regulates olfactory and social recognition in mice. Neuroscience 197:153-61. [PubMed: 21963866]  [MGI Ref ID J:184043]

Kallikourdis M; Andersen KG; Welch KA; Betz AG. 2007. Alloantigen-enhanced accumulation of CCR5+ 'effector' regulatory T cells in the gravid uterus. Proc Natl Acad Sci U S A 104(2):594-9. [PubMed: 17197426]  [MGI Ref ID J:119074]

Kang SJ; Liang HE; Reizis B; Locksley RM. 2008. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity 29(5):819-33. [PubMed: 19006696]  [MGI Ref ID J:142395]

Kastenmuller W; Brandes M; Wang Z; Herz J; Egen JG; Germain RN. 2013. Peripheral Prepositioning and Local CXCL9 Chemokine-Mediated Guidance Orchestrate Rapid Memory CD8(+) T Cell Responses in the Lymph Node. Immunity 38(3):502-13. [PubMed: 23352234]  [MGI Ref ID J:194479]

Kaul M; Ma Q; Medders KE; Desai MK; Lipton SA. 2007. HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection. Cell Death Differ 14(2):296-305. [PubMed: 16841089]  [MGI Ref ID J:132342]

Kennedy A; Webb CD; Hill AA; Gruen ML; Jackson LG; Hasty AH. 2013. Loss of CCR5 results in glucose intolerance in diet-induced obese mice. Am J Physiol Endocrinol Metab 305(7):E897-906. [PubMed: 23941876]  [MGI Ref ID J:203854]

Khan IA; Thomas SY; Moretto MM; Lee FS; Islam SA; Combe C; Schwartzman JD; Luster AD. 2006. CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection. PLoS Pathog 2(6):e49. [PubMed: 16789839]  [MGI Ref ID J:141677]

Kohlmeier JE; Cookenham T; Miller SC; Roberts AD; Christensen JP; Thomsen AR; Woodland DL. 2009. CXCR3 directs antigen-specific effector CD4+ T cell migration to the lung during parainfluenza virus infection. J Immunol 183(7):4378-84. [PubMed: 19734208]  [MGI Ref ID J:152793]

Kohlmeier JE; Miller SC; Smith J; Lu B; Gerard C; Cookenham T; Roberts AD; Woodland DL. 2008. The chemokine receptor CCR5 plays a key role in the early memory CD8+ T cell response to respiratory virus infections. Immunity 29(1):101-13. [PubMed: 18617426]  [MGI Ref ID J:137880]

Kohlmeier JE; Reiley WW; Perona-Wright G; Freeman ML; Yager EJ; Connor LM; Brincks EL; Cookenham T; Roberts AD; Burkum CE; Sell S; Winslow GM; Blackman MA; Mohrs M; Woodland DL. 2011. Inflammatory chemokine receptors regulate CD8(+) T cell contraction and memory generation following infection. J Exp Med 208(8):1621-34. [PubMed: 21788409]  [MGI Ref ID J:177600]

Kroetz DN; Deepe GS Jr. 2011. An aberrant thymus in CCR5-/- mice is coupled with an enhanced adaptive immune response in fungal infection. J Immunol 186(10):5949-55. [PubMed: 21478401]  [MGI Ref ID J:173093]

Kroetz DN; Deepe GS Jr. 2010. CCR5 dictates the equilibrium of proinflammatory IL-17(+) and regulatory Foxp3(+) T cells in fungal infection. J Immunol 184(9):5224-31. [PubMed: 20335531]  [MGI Ref ID J:160480]

Krohn R; Raffetseder U; Bot I; Zernecke A; Shagdarsuren E; Liehn EA; van Santbrink PJ; Nelson PJ; Biessen EA; Mertens PR; Weber C. 2007. Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone mice. Circulation 116(16):1812-20. [PubMed: 17893273]  [MGI Ref ID J:139837]

Lammermann T; Afonso PV; Angermann BR; Wang JM; Kastenmuller W; Parent CA; Germain RN. 2013. Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. Nature 498(7454):371-5. [PubMed: 23708969]  [MGI Ref ID J:198733]

Larena M; Regner M; Lobigs M. 2012. The chemokine receptor CCR5, a therapeutic target for HIV/AIDS antagonists, is critical for recovery in a mouse model of Japanese encephalitis. PLoS One 7(9):e44834. [PubMed: 23028638]  [MGI Ref ID J:191869]

Lee NJ; Choi DY; Song JK; Jung YY; Kim DH; Kim TM; Kim DJ; Kwon SM; Kim KB; Choi KE; Moon DC; Kim Y; Han SB; Hong JT. 2012. Deficiency of C-C chemokine receptor 5 suppresses tumor development via inactivation of NF-kappaB and inhibition of monocyte chemoattractant protein-1 in urethane-induced lung tumor model. Carcinogenesis 33(12):2520-8. [PubMed: 22907530]  [MGI Ref ID J:193223]

Lee YK; Kwak DH; Oh KW; Nam SY; Lee BJ; Yun YW; Kim YB; Han SB; Hong JT. 2009. CCR5 deficiency induces astrocyte activation, Abeta deposit and impaired memory function. Neurobiol Learn Mem 92(3):356-63. [PubMed: 19394434]  [MGI Ref ID J:154425]

Li W; Ren G; Huang Y; Su J; Han Y; Li J; Chen X; Cao K; Chen Q; Shou P; Zhang L; Yuan ZR; Roberts AI; Shi S; Le AD; Shi Y. 2012. Mesenchymal stem cells: a double-edged sword in regulating immune responses. Cell Death Differ 19(9):1505-13. [PubMed: 22421969]  [MGI Ref ID J:204801]

Liu C; Lou Y; Lizee G; Qin H; Liu S; Rabinovich B; Kim GJ; Wang YH; Ye Y; Sikora AG; Overwijk WW; Liu YJ; Wang G; Hwu P. 2008. Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice. J Clin Invest 118(3):1165-75. [PubMed: 18259609]  [MGI Ref ID J:135308]

Lynch EA; Heijens CA; Horst NF; Center DM; Cruikshank WW. 2003. Cutting edge: IL-16/CD4 preferentially induces Th1 cell migration: requirement of CCR5. J Immunol 171(10):4965-8. [PubMed: 14607889]  [MGI Ref ID J:135472]

Ma B; Kang MJ; Lee CG; Chapoval S; Liu W; Chen Q; Coyle AJ; Lora JM; Picarella D; Homer RJ; Elias JA. 2005. Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema. J Clin Invest 115(12):3460-72. [PubMed: 16284650]  [MGI Ref ID J:104580]

Ma B; Liu W; Homer RJ; Lee PJ; Coyle AJ; Lora JM; Lee CG; Elias JA. 2006. Role of CCR5 in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol 176(8):4968-78. [PubMed: 16585593]  [MGI Ref ID J:131183]

Mango RL; Wu QP; West M; McCook EC; Serody JS; van Deventer HW. 2014. C-C Chemokine Receptor 5 on Pulmonary Mesenchymal Cells Promotes Experimental Metastasis via the Induction of Erythroid Differentiation Regulator 1. Mol Cancer Res 12(2):274-82. [PubMed: 24197118]  [MGI Ref ID J:206600]

Mikhak Z; Farsidjani A; Luster AD. 2009. Endotoxin augmented antigen-induced Th1 cell trafficking amplifies airway neutrophilic inflammation. J Immunol 182(12):7946-56. [PubMed: 19494319]  [MGI Ref ID J:149283]

Molesworth-Kenyon S; Mates A; Yin R; Strieter R; Oakes J; Lausch R. 2005. CXCR3, IP-10, and Mig are required for CD4+ T cell recruitment during the DTH response to HSV-1 yet are independent of the mechanism for viral clearance. Virology 333(1):1-9. [PubMed: 15708587]  [MGI Ref ID J:101825]

Moore BB; Paine R rd; Christensen PJ; Moore TA; Sitterding S; Ngan R; Wilke CA; Kuziel WA; Toews GB. 2001. Protection from pulmonary fibrosis in the absence of CCR2 signaling. J Immunol 167(8):4368-77. [PubMed: 11591761]  [MGI Ref ID J:82885]

Moreira AP; Cavassani KA; Massafera Tristao FS; Campanelli AP; Martinez R; Rossi MA; Silva JS. 2008. CCR5-Dependent Regulatory T Cell Migration Mediates Fungal Survival and Severe Immunosuppression. J Immunol 180(5):3049-56. [PubMed: 18292527]  [MGI Ref ID J:131532]

Moreno C; Nicaise C; Gustot T; Quertinmont E; Nagy N; Parmentier M; Louis H; Deviere J. 2006. Chemokine receptor CCR5 deficiency exacerbates cerulein-induced acute pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol 291(6):G1089-99. [PubMed: 16891300]  [MGI Ref ID J:116897]

Nansen A; Christensen JP; Andreasen S SO; Bartholdy C; Christensen JE; Thomsen AR. 2002. The role of CC chemokine receptor 5 in antiviral immunity. Blood 99(4):1237-45. [PubMed: 11830471]  [MGI Ref ID J:74713]

Pak-Wittel MA; Yang L; Sojka DK; Rivenbark JG; Yokoyama WM. 2013. Interferon-gamma mediates chemokine-dependent recruitment of natural killer cells during viral infection. Proc Natl Acad Sci U S A 110(1):E50-9. [PubMed: 23248310]  [MGI Ref ID J:192522]

Park MH; Lee YK; Lee YH; Kim YB; Yun YW; Nam SY; Hwang SJ; Han SB; Kim SU; Hong JT. 2009. Chemokines released from astrocytes promote chemokine receptor 5-mediated neuronal cell differentiation. Exp Cell Res 315(16):2715-26. [PubMed: 19559698]  [MGI Ref ID J:154890]

Passos GF; Figueiredo CP; Prediger RD; Pandolfo P; Duarte FS; Medeiros R; Calixto JB. 2009. Role of the macrophage inflammatory protein-1alpha/CC chemokine receptor 5 signaling pathway in the neuroinflammatory response and cognitive deficits induced by beta-amyloid peptide. Am J Pathol 175(4):1586-97. [PubMed: 19729478]  [MGI Ref ID J:153059]

Peterson KE; Errett JS; Wei T; Dimcheff DE; Ransohoff R; Kuziel WA; Evans L; Chesebro B. 2004. MCP-1 and CCR2 contribute to non-lymphocyte-mediated brain disease induced by Fr98 polytropic retrovirus infection in mice: role for astrocytes in retroviral neuropathogenesis. J Virol 78(12):6449-58. [PubMed: 15163738]  [MGI Ref ID J:91095]

Quinones MP; Ahuja SK; Jimenez F; Schaefer J; Garavito E; Rao A; Chenaux G; Reddick RL; Kuziel WA; Ahuja SS. 2004. Experimental arthritis in CC chemokine receptor 2-null mice closely mimics severe human rheumatoid arthritis. J Clin Invest 113(6):856-66. [PubMed: 15067318]  [MGI Ref ID J:89222]

Rahangdale S; Morgan R; Heijens C; Ryan TC; Yamasaki H; Bentley E; Sullivan E; Center DM; Cruikshank WW. 2006. Chemokine receptor CXCR3 desensitization by IL-16/CD4 signaling is dependent on CCR5 and intact membrane cholesterol. J Immunol 176(4):2337-45. [PubMed: 16455991]  [MGI Ref ID J:129195]

Ramos CD; Canetti C; Souto JT; Silva JS; Hogaboam CM; Ferreira SH; Cunha FQ. 2005. MIP-1{alpha}[CCL3] acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF-{alpha} and LTB4. J Leukoc Biol 78(1):167-77. [PubMed: 15831559]  [MGI Ref ID J:99288]

Ramos MV; Auvynet C; Poupel L; Rodero M; Mejias MP; Panek CA; Vanzulli S; Combadiere C; Palermo M. 2012. Chemokine receptor CCR1 disruption limits renal damage in a murine model of hemolytic uremic syndrome. Am J Pathol 180(3):1040-8. [PubMed: 22203055]  [MGI Ref ID J:181964]

Repeke CE; Ferreira SB Jr; Claudino M; Silveira EM; de Assis GF; Avila-Campos MJ; Silva JS; Garlet GP. 2010. Evidences of the cooperative role of the chemokines CCL3, CCL4 and CCL5 and its receptors CCR1+ and CCR5+ in RANKL+ cell migration throughout experimental periodontitis in mice. Bone 46(4):1122-30. [PubMed: 20053385]  [MGI Ref ID J:162053]

Robays LJ; Maes T; Lebecque S; Lira SA; Kuziel WA; Brusselle GG; Joos GF; Vermaelen KV. 2007. Chemokine receptor CCR2 but not CCR5 or CCR6 mediates the increase in pulmonary dendritic cells during allergic airway inflammation. J Immunol 178(8):5305-11. [PubMed: 17404315]  [MGI Ref ID J:145267]

Robertson P; Means TK; Luster AD; Scadden DT. 2006. CXCR4 and CCR5 mediate homing of primitive bone marrow-derived hematopoietic cells to the postnatal thymus. Exp Hematol 34(3):308-19. [PubMed: 16543065]  [MGI Ref ID J:108468]

Salem ML; Al-Khami AA; El-Naggar SA; Diaz-Montero CM; Chen Y; Cole DJ. 2010. Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells. J Immunol 184(4):1737-47. [PubMed: 20083664]  [MGI Ref ID J:159482]

Sapir Y; Vitenshtein A; Barsheshet Y; Zohar Y; Wildbaum G; Karin N. 2010. A Fusion Protein Encoding the Second Extracellular Domain of CCR5 Arrests Chemokine-Induced Cosignaling and Effectively Suppresses Ongoing Experimental Autoimmune Encephalomyelitis. J Immunol 185(4):2589-99. [PubMed: 20639487]  [MGI Ref ID J:162542]

Sato N; Ahuja SK; Quinones M; Kostecki V; Reddick RL; Melby PC; Kuziel WA; Ahuja SS. 2000. CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cytokines, b cell outgrowth, and sustained neutrophilic inflammation. J Exp Med 192(2):205-18. [PubMed: 10899907]  [MGI Ref ID J:63491]

Sato N; Kuziel WA; Melby PC; Reddick RL; Kostecki V; Zhao W; Maeda N; Ahuja SK; Ahuja SS. 1999. Defects in the generation of IFN-gamma are overcome to control infection with Leishmania donovani in CC chemokine receptor (CCR) 5-, macrophage inflammatory protein-1 alpha-, or CCR2-deficient mice. J Immunol 163(10):5519-25. [PubMed: 10553079]  [MGI Ref ID J:91256]

Sawai CM; Sisirak V; Ghosh HS; Hou EZ; Ceribelli M; Staudt LM; Reizis B. 2013. Transcription factor Runx2 controls the development and migration of plasmacytoid dendritic cells. J Exp Med 210(11):2151-9. [PubMed: 24101375]  [MGI Ref ID J:204587]

Schlecker E; Stojanovic A; Eisen C; Quack C; Falk CS; Umansky V; Cerwenka A. 2012. Tumor-Infiltrating Monocytic Myeloid-Derived Suppressor Cells Mediate CCR5-Dependent Recruitment of Regulatory T Cells Favoring Tumor Growth. J Immunol 189(12):5602-11. [PubMed: 23152559]  [MGI Ref ID J:190855]

Schnickel GT; Bastani S; Hsieh GR; Shefizadeh A; Bhatia R; Fishbein MC; Belperio J; Ardehali A. 2008. Combined CXCR3/CCR5 Blockade Attenuates Acute and Chronic Rejection. J Immunol 180(7):4714-21. [PubMed: 18354195]  [MGI Ref ID J:133385]

Schuh JM; Blease K; Hogaboam CM. 2002. The role of CC chemokine receptor 5 (CCR5) and RANTES/CCL5 during chronic fungal asthma in mice. FASEB J 16(2):228-30. [PubMed: 11744622]  [MGI Ref ID J:74277]

Seki E; De Minicis S; Gwak GY; Kluwe J; Inokuchi S; Bursill CA; Llovet JM; Brenner DA; Schwabe RF. 2009. CCR1 and CCR5 promote hepatic fibrosis in mice. J Clin Invest 119(7):1858-70. [PubMed: 19603542]  [MGI Ref ID J:152548]

Sheahan T; Morrison TE; Funkhouser W; Uematsu S; Akira S; Baric RS; Heise MT. 2008. MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV. PLoS Pathog 4(12):e1000240. [PubMed: 19079579]  [MGI Ref ID J:162707]

Song JK; Park MH; Choi DY; Yoo HS; Han SB; Yoon do Y; Hong JT. 2012. Deficiency of C-C chemokine receptor 5 suppresses tumor development via inactivation of NF-kappaB and upregulation of IL-1Ra in melanoma model. PLoS One 7(5):e33747. [PubMed: 22567084]  [MGI Ref ID J:187266]

Souza AL; Souza PR; Pereira CA; Fernandes A; Guabiraba R; Russo RC; Vieira LQ; Correa A Jr; Teixeira MM; Negrao-Correa D. 2011. Experimental Infection with Schistosoma mansoni in CCR5-Deficient Mice Is Associated with Increased Disease Severity, as CCR5 Plays a Role in Controlling Granulomatous Inflammation. Infect Immun 79(4):1741-9. [PubMed: 21263020]  [MGI Ref ID J:170132]

Strutt TM; McKinstry KK; Dibble JP; Winchell C; Kuang Y; Curtis JD; Huston G; Dutton RW; Swain SL. 2010. Memory CD4+ T cells induce innate responses independently of pathogen. Nat Med 16(5):558-64, 1p following 564. [PubMed: 20436484]  [MGI Ref ID J:160609]

TeKippe M; Harrison DE; Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp Hematol 31(6):521-7. [PubMed: 12829028]  [MGI Ref ID J:115677]

Thapa M; Kuziel WA; Carr DJ. 2007. Susceptibility of CCR5-deficient mice to genital herpes simplex virus type 2 is linked to NK cell mobilization. J Virol 81(8):3704-13. [PubMed: 17267483]  [MGI Ref ID J:121100]

Turner JE; Paust HJ; Bennstein SB; Bramke P; Krebs C; Steinmetz OM; Velden J; Haag F; Stahl RA; Panzer U. 2012. Protective role for CCR5 in murine lupus nephritis. Am J Physiol Renal Physiol 302(11):F1503-15. [PubMed: 22442210]  [MGI Ref ID J:185452]

Turner JE; Paust HJ; Steinmetz OM; Peters A; Meyer-Schwesinger C; Heymann F; Helmchen U; Fehr S; Horuk R; Wenzel U; Kurts C; Mittrucker HW; Stahl RA; Panzer U. 2008. CCR5 deficiency aggravates crescentic glomerulonephritis in mice. J Immunol 181(9):6546-56. [PubMed: 18941245]  [MGI Ref ID J:140716]

Turner SJ; Olivas E; Gutierrez A; Diaz G; Doherty PC. 2007. Disregulated influenza A virus-specific CD8+ T cell homeostasis in the absence of IFN-gamma signaling. J Immunol 178(12):7616-22. [PubMed: 17548597]  [MGI Ref ID J:148590]

Tyner JW; Uchida O; Kajiwara N; Kim EY; Patel AC; O'Sullivan MP; Walter MJ; Schwendener RA; Cook DN; Danoff TM; Holtzman MJ. 2005. CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection. Nat Med 11(11):1180-7. [PubMed: 16208318]  [MGI Ref ID J:102878]

Tzianabos AO; Holsti MA; Zheng XX; Stucchi AF; Kuchroo VK; Strom TB; Glimcher LH; Cruikshank WW. 2008. Functional Th1 cells are required for surgical adhesion formation in a murine model. J Immunol 180(10):6970-6. [PubMed: 18453619]  [MGI Ref ID J:134863]

Walker JK; Ahumada A; Frank B; Gaspard R; Berman K; Quackenbush J; Schwartz DA. 2006. Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness. Am J Respir Cell Mol Biol 34(6):711-8. [PubMed: 16474097]  [MGI Ref ID J:122615]

Warren GL; O'Farrell L; Summan M; Hulderman T; Mishra D; Luster MI; Kuziel WA; Simeonova PP. 2004. Role of CC chemokines in skeletal muscle functional restoration after injury. Am J Physiol Cell Physiol 286(5):C1031-6. [PubMed: 15075201]  [MGI Ref ID J:95296]

Wildenberg ME; van Helden-Meeuwsen CG; van de Merwe JP; Moreno C; Drexhage HA; Versnel MA. 2008. Lack of CCR5 on dendritic cells promotes a proinflammatory environment in submandibular glands of the NOD mouse. J Leukoc Biol 83(5):1194-200. [PubMed: 18285404]  [MGI Ref ID J:134455]

Wysocki CA; Jiang Q; Panoskaltsis-Mortari A; Taylor PA; McKinnon KP; Su L; Blazar BR; Serody JS. 2005. Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease. Blood 106(9):3300-7. [PubMed: 16002422]  [MGI Ref ID J:123905]

Yamagami S; Hamrah P; Miyamoto K; Miyazaki D; Dekaris I; Dawson T; Lu B; Gerard C; Dana MR. 2005. CCR5 chemokine receptor mediates recruitment of MHC class II-positive Langerhans cells in the mouse corneal epithelium. Invest Ophthalmol Vis Sci 46(4):1201-7. [PubMed: 15790880]  [MGI Ref ID J:104985]

Yuan Q; Bromley SK; Means TK; Jones KJ; Hayashi F; Bhan AK; Luster AD. 2007. CCR4-dependent regulatory T cell function in inflammatory bowel disease. J Exp Med 204(6):1327-34. [PubMed: 17548518]  [MGI Ref ID J:125857]

Yurchenko E; Tritt M; Hay V; Shevach EM; Belkaid Y; Piccirillo CA. 2006. CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence. J Exp Med 203(11):2451-60. [PubMed: 17015634]  [MGI Ref ID J:124636]

Zaidi MR; Davis S; Noonan FP; Graff-Cherry C; Hawley TS; Walker RL; Feigenbaum L; Fuchs E; Lyakh L; Young HA; Hornyak TJ; Arnheiter H; Trinchieri G; Meltzer PS; De Fabo EC; Merlino G. 2011. Interferon-gamma links ultraviolet radiation to melanomagenesis in mice. Nature 469(7331):548-53. [PubMed: 21248750]  [MGI Ref ID J:172414]

Zaldivar MM; Berres ML; Sahin H; Nellen A; Heinrichs D; Schmitz P; Gassler N; Streetz KL; Trautwein C; Wasmuth HE. 2012. The chemokine receptor CXCR3 limits injury after acute toxic liver damage. Lab Invest 92(5):724-34. [PubMed: 22430509]  [MGI Ref ID J:183489]

Zernecke A; Liehn EA; Gao JL; Kuziel WA; Murphy PM; Weber C. 2006. Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10. Blood 107(11):4240-3. [PubMed: 16467202]  [MGI Ref ID J:128843]

Zhang N; Schroppel B; Lal G; Jakubzick C; Mao X; Chen D; Yin N; Jessberger R; Ochando JC; Ding Y; Bromberg JS. 2009. Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response. Immunity 30(3):458-69. [PubMed: 19303390]  [MGI Ref ID J:147032]

Zhao X; Sato A; Dela Cruz CS; Linehan M; Luegering A; Kucharzik T; Shirakawa AK; Marquez G; Farber JM; Williams I; Iwasaki A. 2003. CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells. J Immunol 171(6):2797-803. [PubMed: 12960300]  [MGI Ref ID J:120209]

Zhong MX; Kuziel WA; Pamer EG; Serbina NV. 2004. Chemokine receptor 5 is dispensable for innate and adaptive immune responses to Listeria monocytogenes infection. Infect Immun 72(2):1057-64. [PubMed: 14742553]  [MGI Ref ID J:87864]

de Lemos C; Christensen JE; Nansen A; Moos T; Lu B; Gerard C; Christensen JP; Thomsen AR. 2005. Opposing effects of CXCR3 and CCR5 deficiency on CD8+ T cell-mediated inflammation in the central nervous system of virus-infected mice. J Immunol 175(3):1767-75. [PubMed: 16034118]  [MGI Ref ID J:107278]

van Deventer HW; O'Connor W Jr; Brickey WJ; Aris RM; Ting JP; Serody JS. 2005. C-C chemokine receptor 5 on stromal cells promotes pulmonary metastasis. Cancer Res 65(8):3374-9. [PubMed: 15833871]  [MGI Ref ID J:97833]

van Deventer HW; Palmieri DA; Wu QP; McCook EC; Serody JS. 2013. Circulating Fibrocytes Prepare the Lung for Cancer Metastasis by Recruiting Ly-6C+ Monocytes Via CCL2. J Immunol 190(9):4861-7. [PubMed: 23536638]  [MGI Ref ID J:195511]

van Deventer HW; Wu QP; Bergstralh DT; Davis BK; O'Connor BP; Ting JP; Serody JS. 2008. C-C chemokine receptor 5 on pulmonary fibrocytes facilitates migration and promotes metastasis via matrix metalloproteinase 9. Am J Pathol 173(1):253-64. [PubMed: 18535183]  [MGI Ref ID J:137381]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryThe strain is maintained by mating homozygous siblings. Expected coat color from breeding:Black

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2140.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2782.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   100903 B6129PF2/J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.6)