Strain Name:

B6;129S7-Fsttm1Zuk/J

Stock Number:

002788

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Availability:

Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
 
Donating InvestigatorDr. Martin Matzuk,   Baylor College of Medicine

Description
Homozygous mice die within hours after birth due to a failure to breathe. They are smaller in size than normal wildtype siblings and show craniofacial, musculoskeletal, and skin defects.

Control Information

  Control
   Wild-type from the colony
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Facebase: models
007664   129S-Efnb1tm1Sor/J
000646   A/J
000647   A/WySnJ
005709   B6.129-Skitm1Cco/J
002619   B6.129-Tgfb3tm1Doe/J
007453   B6.129P2(Cg)-Dhcr7tm1Gst/J
010525   B6.129S-Notch2tm3Grid/J
010616   B6.129S1-Jag1tm1Grid/J
010546   B6.129S1-Jag2tm1Grid/J
010620   B6.129S1-Notch2tm1Grid/J
009387   B6.129S1-Osr1tm1Jian/J
009386   B6.129S1-Osr2tm1Jian/J
010621   B6.129S1-Snai1tm2.1Grid/J
010617   B6.129S1-Snai2tm1Grid/J
003865   B6.129S2-Itgavtm1Hyn/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
016902   B6.129S5-Irf6Gt(OST398253)Lex/J
003336   B6.129S7-Cdkn1ctm1Sje/J
012843   B6.129X1(Cg)-Slc32a1tm1.1Bgc/J
000026   B6.C3-Gli3Xt-J/J
004275   B6.Cg-Fignfi/Frk
012844   B6.Cg-Gad1tm1.1Bgc/J
006382   B6;129-Casktm1Sud/J
002711   B6;129-Gabrb3tm1Geh/J
004293   B6;129-Shhtm2Amc/J
012603   B6;129-Tgfbr2tm1Karl/J
010618   B6;129S-Jag1tm2Grid/J
010686   B6;129S-Snai1tm2Grid/J
009389   B6;129S1-Bambitm1Jian/J
010619   B6;129S1-Lfngtm1Grid/J
010547   B6;129S1-Notch3tm1Grid/J
010544   B6;129S1-Notch4tm1Grid/J
010722   B6;129S1-Snai2tm2Grid/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
022358   B6;129S6-Rr23tm1Axvi/Mmjax
022359   B6;129S6-Rr24tm1Axvi/Mmjax
022360   B6;129S6-Rr25tm1Axvi/Mmjax
003277   B6;129S7-Acvr2atm1Zuk/J
002990   B6;129S7-Inhbatm1Zuk/J
000523   B6By.Cg-Eh/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000515   B6CBACa Aw-J/A-SfnEr/J
001434   C3HeB/FeJ x STX/Le-Mc1rE-so Gli3Xt-J Zeb1Tw/J
000252   DC/LeJ
005057   FVB.129-Kcnj2tm1Swz/J
012655   FVB.A-Irf6clft1/BeiJ
013100   FVB.C-Prdm16csp1/J
017437   FVB/N-Ckap5TgTn(sb-cHS4,Tyr)2320F-1Ove/J
017438   FVB/N-MidnTg(Tyr)2261EOve/J
017609   FVB/N-Rr16Tn(sb-Tyr)1HCebOve/J
017598   FVB/N-Sdccag8Tn(sb-Tyr)2161B.CA1C2Ove/J
017608   FVB/N-Skor2Tn(sb-Tyr)1799B.CA7BOve/J
017436   FVB/N-Tapt1TgTn(sb-cHS4,Tyr)2508GOve/J
016870   FVB/NJ-Ap2b1Tg(Tyr)427Ove/EtevJ
017434   FVB;B6-Cramp1lTgTn(sb-rtTA,Tyr)2447AOve/J
017594   FVB;B6-Eya4TgTn(Prm1-sb10,sb-Tyr)1739AOve/J
017435   FVB;B6-SlmapTn(sb-rtTA)2426B.SB4Ove/J
003318   STOCK Shhtm1Amc/J
003102   STOCK Tgfb2tm1Doe/J
018624   STOCK Tgfb3tm2(Tgfb1)Vk/J
008469   STOCK Wnt9btm1.2Amc/J
View Facebase: models     (61 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).
Restrictive Dermopathy, Lethal
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Fsttm1Zuk/Fst+

        involves: 129S7/SvEvBrd * C57BL/6
  • skeleton phenotype
  • abnormal rib development
    • in 17% (6 of 35) heterozygotes, development of the thirteenth pair of ribs is limited; not oberved in wild-type controls   (MGI Ref ID J:23925)
    • a higher percentage of heterozygotes show limited formation of the thirteenth rib pair on an inbred 129/SvEv background than on a hybrid 129/SvEv x C57BL/6 background (26.6% vs 17%, respectively)   (MGI Ref ID J:23925)
  • decreased lumbar vertebrae number
    • 60% (21 of 35) heterozygotes have five lumbar vertebrae instead of six; only 2 of 15 wild-type controls show this defect   (MGI Ref ID J:23925)
    • a higher percentage of heterozygotes show five lumbar vertebrae on an inbred 129/SvEv background than on a hybrid 129/SvEv x C57BL/6 background (86.6% vs 60%, respectively)   (MGI Ref ID J:23925)

Fsttm1Zuk/Fsttm1Zuk

        involves: 129S7/SvEvBrd * C57BL/6
  • mortality/aging
  • complete neonatal lethality
    • homozygotes survive to birth but die within a few hours of birth due to respiratory failure   (MGI Ref ID J:23925)
  • craniofacial phenotype
  • absent hard palate
    • 21.4% (6 of 28) newborn homozygotes lack a hard palate   (MGI Ref ID J:23925)
  • absent lower incisors
    • 6 of 34 newborn homozygotes lack lower incisors   (MGI Ref ID J:23925)
  • cleft secondary palate
    • 15.8% (3 of 19) newborn homozygotes display a cleft secondary palate   (MGI Ref ID J:23925)
  • growth retardation of incisors
    • 92% (23 of 34) newborn homozygotes show delayed development of lower incisors   (MGI Ref ID J:23925)
  • growth/size/body phenotype
  • absent hard palate
    • 21.4% (6 of 28) newborn homozygotes lack a hard palate   (MGI Ref ID J:23925)
  • absent lower incisors
    • 6 of 34 newborn homozygotes lack lower incisors   (MGI Ref ID J:23925)
  • cleft secondary palate
    • 15.8% (3 of 19) newborn homozygotes display a cleft secondary palate   (MGI Ref ID J:23925)
  • decreased fetal size
    • at E18.5, homozygotes are smaller than wild-type counterparts   (MGI Ref ID J:23925)
    • decreased fetal weight
      • at E18.5, homozygotes weigh ~12% less than wild-type counterparts   (MGI Ref ID J:23925)
  • fetal growth retardation
    • newborn homozygotes are growth retarded   (MGI Ref ID J:23925)
  • growth retardation of incisors
    • 92% (23 of 34) newborn homozygotes show delayed development of lower incisors   (MGI Ref ID J:23925)
  • muscle phenotype
  • decreased skeletal muscle mass
    • newborn homozygotes show decreased muscle mass in the diaphragmatic, pectoralis major and intercostal muscles   (MGI Ref ID J:23925)
    • however, no primary defects are observed as determined by analysis of ATPase activity, glycogen content and mitochondria   (MGI Ref ID J:23925)
  • skeleton phenotype
  • abnormal rib development
    • in 61% (17 of 28) homozygotes, development of the thirteenth pair of ribs is limited   (MGI Ref ID J:23925)
    • a higher percentage of homozygotes show limited formation of the thirteenth rib pair on an inbred 129/SvEv background than on a hybrid 129/SvEv x C57BL/6 background (81.8% vs 61%, respectively)   (MGI Ref ID J:23925)
  • abnormal rib-sternum attachment
    • in 4 of 28 homozygotes, one or both of the seventh ribs fail to fuse to the sternum   (MGI Ref ID J:23925)
  • decreased lumbar vertebrae number
    • all (28 of 28) newborn homozygotes have five lumbar vertebrae instead of six; only 2 of 15 wild-type controls show this defect   (MGI Ref ID J:23925)
  • decreased rib number
    • in 28.6% (8 of 28) homozygotes, the thirteenth pair of ribs is absent   (MGI Ref ID J:23925)
  • digestive/alimentary phenotype
  • absent hard palate
    • 21.4% (6 of 28) newborn homozygotes lack a hard palate   (MGI Ref ID J:23925)
  • cleft secondary palate
    • 15.8% (3 of 19) newborn homozygotes display a cleft secondary palate   (MGI Ref ID J:23925)
  • homeostasis/metabolism phenotype
  • cyanosis
    • newborn homozygotes appear cyanotic   (MGI Ref ID J:23925)
  • respiratory system phenotype
  • respiratory failure
    • newborn homozygotes fail to breathe   (MGI Ref ID J:23925)
    • mutant lungs are sank in liquid, and alveolar spaces appear poorly expanded, although no primary pulmonary defects are detected   (MGI Ref ID J:23925)
  • integument phenotype
  • abnormal vibrissa morphology
    • mutant whiskers are very thin and incorrectly oriented with shafts projecting parallel before turning perpendicularly   (MGI Ref ID J:23925)
  • hyperkeratosis
    • newborns display a 25% increase in the stratum corneum cells relative to wild-type controls   (MGI Ref ID J:23925)
  • pallor
    • newborn homozygotes appear hypoxic (pale)   (MGI Ref ID J:23925)
  • shiny skin
    • newborn homozygotes display a shiny skin   (MGI Ref ID J:23925)
  • thick epidermis
    • newborn homozygotes show a thickened granular and stratum corneum   (MGI Ref ID J:23925)
  • tight skin
    • newborn homozygotes display a taut skin   (MGI Ref ID J:23925)

Fsttm1Zuk/Fsttm1Zuk

        B6.129S7-Fsttm1Zuk
  • nervous system phenotype
  • abnormal neuron differentiation
    • homozygotes display decreased olfactory epithelium neurogenesis, as shown by significantly reduced neurogenin-1-expressing immediate neuronal precursors and Ncam1-expressing olfactory receptor neurons   (MGI Ref ID J:81451)
    • decreased neuronal precursor cell number   (MGI Ref ID J:81451)
  • abnormal olfactory sensory neuron morphology
    • at E17.5, homozygotes display a 37% decrease in proliferating, neurogenin-1-expressing immediate neuronal precursors within the olfactory epithelium   (MGI Ref ID J:81451)
  • taste/olfaction phenotype
  • abnormal olfactory epithelium morphology
    • homozygotes display a 38% decrease in thickness of the olfactory epithelium   (MGI Ref ID J:81451)
    • abnormal olfactory sensory neuron morphology
      • at E17.5, homozygotes display a 37% decrease in proliferating, neurogenin-1-expressing immediate neuronal precursors within the olfactory epithelium   (MGI Ref ID J:81451)
  • vision/eye phenotype
  • thin retinal ganglion layer
    • mutant retinas exhibit a 26% reduction in the number of cells in the ganglion cell layer and a marked decrease in thickness of the differentiated ganglion cell layer   (MGI Ref ID J:99244)
    • unlike the situation in olfactory epithelium, mutant retinas display normal overall thickness as well as normal progenitor cell proliferation   (MGI Ref ID J:99244)
    • in addition, mutant retinas show no obvious differences in amacrine cell or photoreceptor production relative to wild-type   (MGI Ref ID J:99244)
  • respiratory system phenotype
  • abnormal olfactory epithelium morphology
    • homozygotes display a 38% decrease in thickness of the olfactory epithelium   (MGI Ref ID J:81451)
    • abnormal olfactory sensory neuron morphology
      • at E17.5, homozygotes display a 37% decrease in proliferating, neurogenin-1-expressing immediate neuronal precursors within the olfactory epithelium   (MGI Ref ID J:81451)
  • craniofacial phenotype
  • abnormal olfactory epithelium morphology
    • homozygotes display a 38% decrease in thickness of the olfactory epithelium   (MGI Ref ID J:81451)
    • abnormal olfactory sensory neuron morphology
      • at E17.5, homozygotes display a 37% decrease in proliferating, neurogenin-1-expressing immediate neuronal precursors within the olfactory epithelium   (MGI Ref ID J:81451)
  • cellular phenotype
  • abnormal neuron differentiation
    • homozygotes display decreased olfactory epithelium neurogenesis, as shown by significantly reduced neurogenin-1-expressing immediate neuronal precursors and Ncam1-expressing olfactory receptor neurons   (MGI Ref ID J:81451)
    • decreased neuronal precursor cell number   (MGI Ref ID J:81451)
  • growth/size/body phenotype
  • abnormal olfactory epithelium morphology
    • homozygotes display a 38% decrease in thickness of the olfactory epithelium   (MGI Ref ID J:81451)
    • abnormal olfactory sensory neuron morphology
      • at E17.5, homozygotes display a 37% decrease in proliferating, neurogenin-1-expressing immediate neuronal precursors within the olfactory epithelium   (MGI Ref ID J:81451)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Fsttm1Zuk/Fst+

        involves: 129S7/SvEvBrd
  • skeleton phenotype
  • abnormal rib development
    • in 26.6% (4 of 15) heterozygotes, development of the thirteenth pair of ribs is limited; not oberved in wild-type controls   (MGI Ref ID J:23925)
    • a higher percentage of heterozygotes show limited formation of the thirteenth rib pair on an inbred 129/SvEv background than on a hybrid 129/SvEv x C57BL/6 background (26.6% vs 17%, respectively)   (MGI Ref ID J:23925)
  • decreased lumbar vertebrae number
    • 86.6% (13 of 15) heterozygotes have five lumbar vertebrae instead of six found in wild-type controls   (MGI Ref ID J:23925)
    • a higher percentage of heterozygotes show five lumbar vertebrae on an inbred 129/SvEv background than on a hybrid 129/SvEv x C57BL/6 background (86.6% vs 60%, respectively)   (MGI Ref ID J:23925)

Fsttm1Zuk/Fst+

        B6.129S7-Fsttm1Zuk
  • muscle phenotype
  • abnormal extensor digitorum longus morphology
    • increase in the percentage of oxidative type I fibers   (MGI Ref ID J:182827)
  • abnormal gastrocnemius morphology
    • increase in the number of oxidative type I fibers   (MGI Ref ID J:182827)
    • decreased gastrocnemius weight   (MGI Ref ID J:182827)
  • abnormal muscle physiology
    • lower twitch and tetanic force production   (MGI Ref ID J:182827)
    • but no change in specific force   (MGI Ref ID J:182827)
  • abnormal pectoral muscle morphology
    • decreased weight   (MGI Ref ID J:182827)
  • abnormal skeletal muscle fiber morphology
    • increase in the proportion of smaller fibers that stain more darkly in hematoxylin and eosin stained sections corresponding to mixed glycolytic/oxidative type IIa fibers   (MGI Ref ID J:182827)
    • shift towards more oxidative fibers   (MGI Ref ID J:182827)
    • decrease in mean fiber diameter for each fiber type   (MGI Ref ID J:182827)
  • decreased quadriceps weight   (MGI Ref ID J:182827)
  • decreased skeletal muscle weight
    • about 15-20% lower than wild-type   (MGI Ref ID J:182827)
    • decreased triceps weight   (MGI Ref ID J:182827)
  • homeostasis/metabolism phenotype
  • increased physiological sensitivity to xenobiotic
    • impaired muscle regeneration and enhanced fibrosis in the gastrocnemius muscle following cardiotoxin-induced injury   (MGI Ref ID J:182827)

Fsttm1Zuk/Fsttm1Zuk

        involves: 129S7/SvEvBrd
  • mortality/aging
  • complete neonatal lethality
    • homozygotes survive to birth but die within a few hours of birth due to respiratory failure   (MGI Ref ID J:23925)
  • craniofacial phenotype
  • absent hard palate
    • 55% (6 of 11) newborn homozygotes lack a hard palate   (MGI Ref ID J:23925)
  • growth retardation of incisors
    • all newborn homozygotes (11 of 11) show delayed development of lower incisors   (MGI Ref ID J:23925)
  • growth/size/body phenotype
  • absent hard palate
    • 55% (6 of 11) newborn homozygotes lack a hard palate   (MGI Ref ID J:23925)
  • decreased fetal size
    • at E18.5, homozygotes are smaller than wild-type counterparts   (MGI Ref ID J:23925)
    • decreased fetal weight
      • at E18.5, homozygotes weigh ~12% less than wild-type counterparts   (MGI Ref ID J:23925)
  • fetal growth retardation
    • newborn homozygotes are growth retarded   (MGI Ref ID J:23925)
  • growth retardation of incisors
    • all newborn homozygotes (11 of 11) show delayed development of lower incisors   (MGI Ref ID J:23925)
  • muscle phenotype
  • decreased skeletal muscle mass
    • newborn homozygotes show decreased muscle mass in the diaphragmatic, pectoralis major and intercostal muscles   (MGI Ref ID J:23925)
    • however, no primary defects are observed as determined by analysis of ATPase activity, glycogen content and mitochondria   (MGI Ref ID J:23925)
  • skeleton phenotype
  • abnormal rib development
    • in 81.8% (9 of 11) homozygotes, development of the thirteenth pair of ribs is limited   (MGI Ref ID J:23925)
    • a higher percentage of homozygotes show limited formation of the thirteenth rib pair on an inbred 129/SvEv background than on a hybrid 129/SvEv x C57BL/6 background (81.8% vs 61%, respectively)   (MGI Ref ID J:23925)
  • decreased lumbar vertebrae number
    • all (11 of 11) newborn homozygotes have five lumbar vertebrae instead of six found in wild-type mice   (MGI Ref ID J:23925)
  • decreased rib number
    • in 2 of 11 homozygotes, the thirteenth pair of ribs is absent   (MGI Ref ID J:23925)
  • digestive/alimentary phenotype
  • absent hard palate
    • 55% (6 of 11) newborn homozygotes lack a hard palate   (MGI Ref ID J:23925)
  • homeostasis/metabolism phenotype
  • cyanosis
    • newborn homozygotes appear cyanotic   (MGI Ref ID J:23925)
  • respiratory system phenotype
  • respiratory failure
    • newborn homozygotes fail to breathe   (MGI Ref ID J:23925)
    • mutant lungs are sank in liquid, and alveolar spaces appear poorly expanded, although no primary pulmonary defects are detected   (MGI Ref ID J:23925)
  • integument phenotype
  • abnormal vibrissa morphology
    • mutant whiskers are very thin and incorrectly oriented with shafts projecting parallel before turning perpendicularly   (MGI Ref ID J:23925)
  • hyperkeratosis
    • newborns display a 25% increase in the stratum corneum cells relative to wild-type controls   (MGI Ref ID J:23925)
  • pallor
    • newborn homozygotes appear hypoxic (pale)   (MGI Ref ID J:23925)
  • shiny skin
    • newborn homozygotes display a shiny skin   (MGI Ref ID J:23925)
  • thick epidermis
    • newborn homozygotes show a thickened granular and stratum corneum   (MGI Ref ID J:23925)
  • tight skin
    • newborn homozygotes display a taut skin   (MGI Ref ID J:23925)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Fsttm1Zuk related

Dermatology Research
Skin and Hair Texture Defects

Developmental Biology Research
Craniofacial and Palate Defects
Embryonic Lethality (Homozygous)
Growth Defects
Skeletal Defects

Reproductive Biology Research
Endocrine Deficiencies Affecting Gonads
Fertility Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Fsttm1Zuk
Allele Name targeted mutation 1, Martin M Matzuk
Allele Type Targeted (Null/Knockout)
Common Name(s) Fst-; Fsttm1; fsm1;
Mutation Made ByDr. Martin Matzuk,   Baylor College of Medicine
Strain of Origin129S7/SvEvBrd-Hprt
ES Cell Line NameAB2.1
ES Cell Line Strain129S7/SvEvBrd-Hprt
Gene Symbol and Name Fst, follistatin
Chromosome 13
Gene Common Name(s) FOL1; FS; Fst-288; RATFOL1;
Molecular Note An Hprt expression cassette replaced the entire gene, including all 6 exons. [MGI Ref ID J:23925]

Genotyping

Genotyping Information

Genotyping Protocols

Generic HPRT_Alternative,

Separated MCA


Generic HPRT_Alternative, Separated PCR
Generic HPRT_Alternative, Standard PCR
Human HPRT/KO2, Separated PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Matzuk MM; Lu N; Vogel H; Sellheyer K; Roop DR; Bradley A. 1995. Multiple defects and perinatal death in mice deficient in follistatin [see comments] Nature 374(6520):360-3. [PubMed: 7885475]  [MGI Ref ID J:23925]

Additional References

Fsttm1Zuk related

Antsiferova M; Klatte JE; Bodo E; Paus R; Jorcano JL; Matzuk MM; Werner S; Kogel H. 2009. Keratinocyte-derived follistatin regulates epidermal homeostasis and wound repair. Lab Invest 89(2):131-41. [PubMed: 19079322]  [MGI Ref ID J:144223]

Beites CL; Hollenbeck PL; Kim J; Lovell-Badge R; Lander AD; Calof AL. 2009. Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue. Development 136(13):2187-97. [PubMed: 19474151]  [MGI Ref ID J:149988]

Braga M; Reddy ST; Vergnes L; Pervin S; Grijalva V; Stout D; David J; Li X; Tomasian V; Reid CB; Norris KC; Devaskar SU; Reue K; Singh R. 2014. Follistatin promotes adipocyte differentiation, browning, and energy metabolism. J Lipid Res 55(3):375-84. [PubMed: 24443561]  [MGI Ref ID J:208789]

Gokoffski KK; Wu HH; Beites CL; Kim J; Kim EJ; Matzuk MM; Johnson JE; Lander AD; Calof AL. 2011. Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate. Development 138(19):4131-42. [PubMed: 21852401]  [MGI Ref ID J:176045]

Jhaveri S; Erzurumlu RS; Chiaia N; Kumar TR; Matzuk MM. 1998. Defective whisker follicles and altered brainstem patterns in activin and follistatin knockout mice. Mol Cell Neurosci 12(4-5):206-19. [PubMed: 9828086]  [MGI Ref ID J:50975]

Jorgez CJ; Klysik M; Jamin SP; Behringer RR; Matzuk MM. 2004. Granulosa cell-specific inactivation of follistatin causes female fertility defects. Mol Endocrinol 18(4):953-67. [PubMed: 14701941]  [MGI Ref ID J:89081]

Jukkola T; Lahti L; Naserke T; Wurst W; Partanen J. 2006. FGF regulated gene-expression and neuronal differentiation in the developing midbrain-hindbrain region. Dev Biol 297(1):141-57. [PubMed: 16782087]  [MGI Ref ID J:112633]

Kim J; Wu HH; Lander AD; Lyons KM; Matzuk MM; Calof AL. 2005. GDF11 controls the timing of progenitor cell competence in developing retina. Science 308(5730):1927-30. [PubMed: 15976303]  [MGI Ref ID J:99244]

Klein OD; Lyons DB; Balooch G; Marshall GW; Basson MA; Peterka M; Boran T; Peterkova R; Martin GR. 2008. An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors. Development 135(2):377-85. [PubMed: 18077585]  [MGI Ref ID J:130572]

Lee SJ; Lee YS; Zimmers TA; Soleimani A; Matzuk MM; Tsuchida K; Cohn RD; Barton ER. 2010. Regulation of muscle mass by follistatin and activins. Mol Endocrinol 24(10):1998-2008. [PubMed: 20810712]  [MGI Ref ID J:182827]

Lee YS; Lee SJ. 2013. Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2. Proc Natl Acad Sci U S A 110(39):E3713-22. [PubMed: 24019467]  [MGI Ref ID J:201148]

Lin SY; Craythorn RG; O'Connor AE; Matzuk MM; Girling JE; Morrison JR; de Kretser DM. 2008. Female infertility and disrupted angiogenesis are actions of specific follistatin isoforms. Mol Endocrinol 22(2):415-29. [PubMed: 17932109]  [MGI Ref ID J:130061]

Nakamura M; Matzuk MM; Gerstmayer B; Bosio A; Lauster R; Miyachi Y; Werner S; Paus R. 2003. Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin. FASEB J 17(3):497-9. [PubMed: 12514121]  [MGI Ref ID J:118511]

Pangas SA. 2012. Regulation of the ovarian reserve by members of the transforming growth factor beta family. Mol Reprod Dev 79(10):666-79. [PubMed: 22847922]  [MGI Ref ID J:190579]

Roy A; Matzuk MM. 2006. Deconstructing mammalian reproduction: using knockouts to define fertility pathways. Reproduction 131(2):207-19. [PubMed: 16452715]  [MGI Ref ID J:108425]

Wang XP; Suomalainen M; Jorgez CJ; Matzuk MM; Wankell M; Werner S; Thesleff I. 2004. Modulation of activin/bone morphogenetic protein signaling by follistatin is required for the morphogenesis of mouse molar teeth. Dev Dyn 231(1):98-108. [PubMed: 15305290]  [MGI Ref ID J:91704]

Wang XP; Suomalainen M; Jorgez CJ; Matzuk MM; Werner S; Thesleff I. 2004. Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation. Dev Cell 7(5):719-30. [PubMed: 15525533]  [MGI Ref ID J:94518]

Wu HH; Ivkovic S; Murray RC; Jaramillo S; Lyons KM; Johnson JE; Calof AL. 2003. Autoregulation of Neurogenesis by GDF11. Neuron 37(2):197-207. [PubMed: 12546816]  [MGI Ref ID J:81451]

Yao HH; Aardema J; Holthusen K. 2006. Sexually dimorphic regulation of inhibin Beta B in establishing gonadal vasculature in mice. Biol Reprod 74(5):978-83. [PubMed: 16452457]  [MGI Ref ID J:107812]

Yao HH; Matzuk MM; Jorgez CJ; Menke DB; Page DC; Swain A; Capel B. 2004. Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. Dev Dyn 230(2):210-5. [PubMed: 15162500]  [MGI Ref ID J:90277]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


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Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Wild-type from the colony
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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